| use of high-dose cytarabine to enhance cisplatin cytotoxicity-effects on the response and overall survival rates of advanced head and neck cancer patients. | it has been reported that cytarabine, acting by at least two different mechanisms, enhances the cytotoxic effect of cisplatin in in vitro systems. the aim of this open, prospective, randomised study was to estimate the eventual benefits from the inclusion of high-dose cytarabine in the cisplatin-5-fluorouracil (5-fu) regimen as first-line treatment of patients with advanced head and neck cancer. the study recruited successive patients with unresectable grade i/ii head and neck cancer who were no ... | 2002 | 12110494 |
| structure and mechanism of t4 polynucleotide kinase: an rna repair enzyme. | t4 polynucleotide kinase (pnk), in addition to being an invaluable research tool, exemplifies a family of bifunctional enzymes with 5'-kinase and 3'-phosphatase activities that play key roles in rna and dna repair. t4 pnk is a homotetramer composed of a c-terminal phosphatase domain and an n-terminal kinase domain. the 2.0 a crystal structure of the isolated kinase domain highlights a tunnel-like active site through the heart of the enzyme, with an entrance on the 5' oh acceptor side that can ac ... | 2002 | 12110598 |
| therapy options in cutaneous t-cell lymphoma. | the treatment of cutaneous t-cell lymphoma (ctcl) is continually evolving, as new and emerging drugs are added to the growing arsenal of ctcl therapy. the availability of newly approved investigational therapies, such as bexarotene, denileukin diftitox (dab389- il2), monoclonal antibodies and novel chemotherapeutic agents, adds complexity to decisions on the management and treatment of ctcl patients. in formulating a treatment plan, therapeutic options are best approached through consideration o ... | 2001 | 12113107 |
| high-sensitivity human thyroglobulin (htg) immunoradiometric assay in the follow-up of patients with differentiated thyroid cancer. | circulating human thyroglobulin (htg) measurement has a pivotal role in the management of patients affected by differentiated thyroid cancer (dtc). generally, htg serum concentration less than 1 ng/ml is considered a marker of complete remission after total thyroid ablation. recently, high-sensitivity immunoradiometric assays (irma) have been developed to detect very low htg serum concentrations. the present study was undertaken to test a newly developed high-sensitivity htg irma and to evaluate ... | 2002 | 12113292 |
| locoregional recurrence and survival after curative resection of adenocarcinoma of the colon. | there is wide variability in reported locoregional recurrence rates after curative resection of adenocarcinoma of the intraperitoneal colon, and there is no universally accepted surgical technique regarding length of the resected specimen or extent of lymphadenectomy. the aim of this study was to determine the disease-free survival, locoregional failure, and perioperative morbidity of patients undergoing curative resection of colon adenocarcinoma. | 2002 | 12113543 |
| epithelial cyst of thyroid. | a benign thyroid cyst lined by thyroid follicular epithelial cells lacking immunoreactivity to thyroglobulin is reported. the patient had a 3 yr history of a large cyst in the lateral anterior neck, with no symptoms of hyperthyroidism or hyperparathyroidism. water-clear fluid was repeatedly aspirated; analysis indicated the absence of parathyroid hormone (pth0), t3, and t4. hemithyroidectomy revealed a simple epithelial cyst. such cysts are rare, comprising approx 1% of thyroid nodules. a differ ... | 1997 | 12114674 |
| a plurihormonal tsh-secreting pituitary microadenoma: report of a case with an atypical clinical presentation and transient response to bromocriptine therapy. | inappropriate secretion of thyrotropin (tsh) is a rare cause of hyperthyroidism, and it is caused by either a tsh-producing pituitary adenoma (usually a macroadenoma) or to selective pituitary resistance to thyroid hormone. the case of a 31-yr-old male who presented with clinical features of thyrotoxicosis, including episodes of thyrotoxic paralysis, and a thyroid profile characterized by free hyperthyroxinemia and hypertriiodothyronemia with a nonsuppressed, inadequately normal tsh is reported. ... | 1997 | 12114675 |
| pathological findings in dyshormonogenetic goiter with defective iodide transport. | an adult male patient (38 yr old) with a large congenital goiter with hypothyroidism was suspected of having a defective iodide (l) transport mechanism based on low thyroid uptake and a very low salivary/plasma ratio. moreover the high serum levels of tsh (104 uu/ml) declined to 7.2 uu/ml with a corresponding normalization of serum total t4 concentration, after 40 d of treatment with lugolts solution (6 mg l/d). thyroid surgery was performed because a fine-needle aspiration biopsy of a nodule re ... | 1998 | 12114713 |
| improved survival with perilymphatic interleukin 2 in patients with resectable squamous cell carcinoma of the oral cavity and oropharynx. | the current randomized, multicenter, phase iii trial was conducted to determine whether the disease free interval and overall survival of patients with t2-t4,n0-n3,m0 squamous cell carcinoma (scc) of the oral cavity or oropharynx could be extended through the combination of surgery (and radiotherapy, if required) with perilymphatic recombinant il-2 (ril-2). | 2002 | 12115321 |
| how many nodes must be examined to accurately stage gastric carcinomas? results from a population based study. | there are few population based data about lymphadenectomy practices in resections for stomach carcinoma. the aim of the current study was to describe these practices and to determine how many nodes must be examined in order to accurately stage gastric carcinoma. | 2002 | 12115373 |
| cisplatin, tegafur, and leucovorin: a moderately effective and minimally toxic outpatient neoadjuvant chemotherapy for locally advanced squamous cell carcinoma of the head and neck. | to evaluate the efficacy and toxicity of cisplatin, tegafur, and leucovorin as neoadjuvant chemotherapy (ct) for patients with advanced, nonmetastatic squamous cell carcinoma of the head and neck (scchn). | 2002 | 12115388 |
| adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasible. | adenosquamous/squamous cell carcinoma of the gallbladder generally has been considered a lethal disease. the objective of this study was to clarify the effectiveness of resection for patients with adenosquamous/squamous cell carcinoma of the gallbladder. | 2002 | 12115390 |
| combined-modality treatment and selective organ preservation in invasive bladder cancer: long-term results. | to evaluate our long-term experience with combined modality treatment and selective bladder preservation and to identify factors that may predict treatment response, risk of relapse, and survival. | 2002 | 12118019 |
| evaluation of an in-house enzyme-linked immunosorbent assay for quantitative measurement of serum total thyroxine concentration in dogs and cats. | to compare serum total thyroxine (t4) concentrations obtained with an in-house elisa and a validated radioimmunoassay (ria). | 2002 | 12118587 |
| transient hyperthyroidism of hyperemesis gravidarum. | to characterise the clinical, biochemical and thyroid antibody profile in women with transient hyperthyroidism of hyperemesis gravidarum. | 2002 | 12118648 |
| histone h1(0) and its carboxyl-terminal domain bind in the major groove of dna. | the binding of histone h1(0) to t4 bacteriophage dna was investigated using thermal denaturation of the dna titrated with varying concentrations of protein. the h1(0) used was expressed in and purified from a strain of e. coli and is therefore homogeneous with respect to h1 subtype and posttranslational modifications. two types of t4 dna were used: wild-type, which contains a modification of the cytosine residues that projects into the major groove: and a mutant type, which lacks the modificatio ... | 2002 | 12119037 |
| management of immature heterotopic ossification (ho) of the hip. | a case of extensive heterotopic ossification involving the left hip in a 16 year old girl who sustained non traumatic spinal paralysis at t4 asia scale a. this case demonstrates the practical difficulties facing clinicians involved in the rehabilitation of this paraplegic patient who required intervention before full maturation of her left hip heterotopic ossification (ho). the patient was developing a rapidly progressive fixed scoliosis and severe difficulty in achieving a proper seating postur ... | 2002 | 12124665 |
| mechanism of the prorelaxing effect of thyroxine on the sphincter of oddi. | disturbances in the function of sphincter of oddi (so) may prevent normal bile flow and thus enhance the probability of common bile duct stone (cbds) formation. previously, we have shown increased prevalence of hypothyroidism in cbds patients. | 2002 | 12126244 |
| dietary accumulation and biochemical responses of juvenile rainbow trout (oncorhynchus mykiss) to 3,3',4,4',5-pentachlorobiphenyl (pcb 126). | juvenile rainbow trout (oncorhynchus mykiss) (initial weights 2-5 g) were exposed to three dietary concentrations (0, 12.4 and 126 ng g(-1), wet weight) of a 14c-labelled 3,3',4,4',5-pentachlorobiphenyl (pcb 126) for 30 days followed by 160 days of clean food. we assessed bioaccumulation, histology (liver and thyroid) and biochemical responses (liver ethoxyresorufin-o-deethylase (erod), liver vitamins (retinoids and tocopherol) and muscle thyroid hormone levels) along with growth and survival. t ... | 2002 | 12127732 |
| thyroid hormone-dependent development of mouse cerebellar purkinje cells in vitro. | using a well-defined medium with insulin, transferrin and selenium but without serum and albumin, we quantitatively determined the effect of thyroid hormones on the development of purkinje cells in mouse cerebellar monolayer cultures. addition of a thyroid hormone, t3 or t4, to the serum-free medium resulted in a highly elaborate dendritic development of purkinje cells. the cultured purkinje cells in the presence of t4 even showed similarities in shape and in synapse formation to normal purkinje ... | 2002 | 12128254 |
| helical ct of the local spread of carcinoma of the gallbladder: evaluation according to the tnm system in patients who underwent surgical resection. | our aim was to evaluate the performance of helical ct as an aid in the preoperative diagnosis of the spread of carcinomas of the gallbladder. | 2002 | 12130444 |
| t-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival. | preoperative chemoradiation therapy is used widely in the treatment of rectal cancer. the predictive value of response to neoadjuvant remains uncertain. we retrospectively evaluated the impact of response to preoperative and, specifically, of t-level downstaging, nodal downstaging, and complete pathologic response after chemoradiation therapy on oncologic outcome of patients with locally advanced rectal cancer. | 2002 | 12130878 |
| bicalutamide as immediate therapy either alone or as adjuvant to standard care of patients with localized or locally advanced prostate cancer: first analysis of the early prostate cancer program. | we determine the efficacy and tolerability of bicalutamide as immediate therapy, either alone or as adjuvant to treatment of curative intent, in patients with clinically localized or locally advanced prostate cancer. | 2002 | 12131282 |
| segmental recording of cortical motor evoked potentials from thoracic paravertebral myotomes in complete spinal cord injury. | a study of thoracic paravertebral muscle motor-evoked potentials using transcranial magnetic stimulation in spinal cord injury patients and control participants. | 2002 | 12131743 |
| in vivo effects of bisphenol a on the polecat (mustela putorius). | bisphenol a (bpa), an environmental estrogen derived from the plastic industry, was given orally via incorporation into the food of 30 male and female polecats at 3 different doses (10, 50, or 250 mg/kg body weight/day) for 2 wk with 10 animals acting as controls. several hormone levels in the plasma were determined as well as the activities of the phase i and ii biotransformation enzymes 7-ethoxyresorufin o-deethylase (erod), cytosolic glutathione s-transferase (gst), and udp-glucuronosyltransf ... | 2002 | 12133237 |
| polybrominated diphenyl ethers (pbdes), polychlorinated biphenyls (pcbs) and chlorinated paraffins (cps) in rats-testing interactions and mechanisms for thyroid hormone effects. | the effects of the polybrominated diphenyl ether (pbde) congener 2,2'4, 4'-tetrabromodiphenylether (de-47), and technical preparations of polychlorinated biphenyls (pcbs; aroclor 1254) and chlorinated paraffins (cps; witaclor 171p) on thyroid hormone (th) levels were examined in rats. to study possible interactive effects, also combinations of the three compounds were used. thus, female sprague-dawley rats, 7 weeks old, were treated with approximately isomolar doses (ca. 30 micromol/kg bw per da ... | 2002 | 12135626 |
| the origin of sensory innervation of the peritoneum in the rat. | the distribution of sensory neurons innervating the peritoneum was studied using axonal transport of fluoro-gold. the tracer was injected into parietal peritoneum, diaphragm, mesentery, mesocolon, visceral peritoneum covering the stomach, small intestine, colon, liver, spleen, kidney, urinary bladder or uterus. after ten days of survival bilateral dorsal root ganglia from c2 to s6, and the nodose ganglia were dissected. the cryostat sections of these ganglia were mounted on glass slides and obse ... | 2002 | 12136261 |
| thyroid status in juvenile alligators (alligator mississippiensis) from contaminated and reference sites on lake okeechobee, florida, usa. | exposure to environmental contaminants has been shown to alter normal thyroid function in various wildlife species, including the american alligator (alligator mississippiensis). abnormalities in circulating levels of the thyroid hormone thyroxine (t4) have been reported in juvenile alligators from several contaminated lakes in florida. to further elucidate these functional thyroid abnormalities, this study examines the structure of thyroids and circulating t4 concentrations from juvenile alliga ... | 2002 | 12137046 |
| [statistical analysis of maxillary sinus squamous cell carcinoma]. | cases of squamous cell carcinoma of the maxillary sinus initially treated at keio university hospital between january 1981 and december 1998 studied retrospectively involved 60 untreated cases--46 men and 14 women aged 36 to 86 years (mean: 59.8 years). of these, 7 had t2, 41 t3 and 12 t4 tumors based on 1997 ajcc tnm classification. seven (11.7%) had nodal involvement but none had distant metastasis at diagnosis. of the 60, 53 (88.3%) were stage iii or iv. prognostic factors and survival were s ... | 2002 | 12138701 |
| sarcoidosis within a pituitary adenoma. | a 54 year old man presented with frontal headaches for one year. a ct scan of the head revealed a pituitary mass. he denied a change in vision or galactorrhea, but did have decreased frequency of erections and a recent episode of renal stones. on physical exam, the cranial nerves were normal. visual field exam revealed mild bilateral temporal defects. the genitalia were normal and the testes were soft. laboratory evaluation revealed: na, 134 mm/l; k, 6.7 mm/l; cl, 104 mm/l; hco3, 22 mm/l; bun, 4 ... | 2001 | 12138993 |
| chaperonin-mediated folding of bacteriophage t4 major capsid protein. ii. production of gene product 23 deletion mutants. | folding of bacteriophage t4 major capsid protein, gene product 23 (534 a.a.), is aided by two proteins: e. coli groel chaperonin and viral gp31 co-chaperonin. in the present work a set of mutants with extensive deletions inside gene 23 using controlled digestion with bal31 nuclease has been constructed. proteins with deletions were co-expressed from plasmid vectors with phage gp31 co-chaperonin. deletions from 8 to 33 a.a. in the n-terminal region of the gp23 molecule covering the protein proteo ... | 2002 | 12139482 |
| high affinity of endonuclease vii for the holliday structure containing one nick ensures productive resolution. | during homologous recombination, genetic information is physically exchanged between parental dnas via crossing single strands of the same polarity within a four-way dna junction called a holliday structure. this process is terminated by the endonucleolytic activity of resolvases, which convert the four-way dna back to two double strands. to achieve productive resolution, the two subunits of the dimeric enzymes introduce two single-strand cuts positioned symmetrically in opposite strands across ... | 2002 | 12139930 |
| effect of manganese on in vitro replication of damaged dna catalyzed by the herpes simplex virus type-1 dna polymerase. | in vitro bypass of damaged dna by replicative dna polymerases is usually blocked by helix-distorting or bulky dna lesions. in this study, we report that substitution of the divalent metal ion mg2+ with mn2+ promotes quantitative replication of model dna substrates containing the major cisplatin or n-2-acetylaminofluorene adducts by the catalytic subunit (ul30) of the replicative dna polymerase of herpes simplex virus. the ability of mn2+ ions to confer bypass of bulky lesions was not observed wi ... | 2002 | 12140316 |
| rna determinants of translational operator recognition by the dna polymerases of bacteriophages t4 and rb69. | the dna polymerases (gp43s) of the two related phages t4 and rb69 are dna-binding proteins that also function as mrna-binding autogenous translational repressors. as repressors, t4 gp43 is narrowly specific to its own mrna whereas rb69 gp43 is equally effective against mrna for either protein. we used in vitro rnase-sensitivity and rna footprinting assays to identify features of the non-identical t4 and rb69 mrna targets (translational operators) that allow for their identical binding affinities ... | 2002 | 12140318 |
| modular engineering of a group i intron ribozyme. | all group i intron ribozymes contain a conserved core region consisting of two helical domains, p4-p6 and p3-p7. recent studies have demonstrated that the elements required for catalysis are concentrated in the p3-p7 domain. we carried out in vitro selection experiments by using three newly constructed libraries on a variant of the t4 td group i ribozyme containing only a p3-p7 domain in its core. selected variants with new peripheral elements at l7.1, l8 or l9 after nine cycles efficiently cata ... | 2002 | 12140333 |
| [in carciraded inguinoscrotal hernia within sigmodial perforated adenocarcinoma and peritonitis in the scrotal sac.a case report] | a case of perforated sigmoid colon, complicated with peritonitis inside the inguinal hernia scrotal sack is presented. a 91 years old male with reducible inguinal tumor from 4 years ago, that 4 days before hospitalization turns to an unyielding restitution inguinal hernia. producing an intestinal obstruction. sigmoidectomy with a hartman colostomy and inguinal herniorraphy was done. anatomopatologycal study show adenocarcinoma of colon, tubular type, with moderate differentation. tnm classificat ... | 2000 | 12140589 |
| interatomic potentials and solvation parameters from protein engineering data for buried residues. | van der waals (vdw) interaction energies between different atom types, energies of hydrogen bonds (h-bonds), and atomic solvation parameters (asps) have been derived from the published thermodynamic stabilities of 106 mutants with available crystal structures by use of an originally designed model for the calculation of free-energy differences. the set of mutants included substitutions of uncharged, inflexible, water-inaccessible residues in alpha-helices and beta-sheets of t4, human, and hen ly ... | 2002 | 12142453 |
| balloon sheath miniprobe compared to conventional eus in the staging of colorectal cancer. | conventional endoscopic ultrasonography was a valuable modality in staging the invasion depth of colon cancer. however, it is not widely used because of its difficulty in detecting small or flat lesions and obtaining a cross-sectional image due to tight stricture of tumor lesions and in those lesions located at or over a bend of the colon. due to this, mistaging or understaging is often seen. we conducted a prospective study using a new technique and instrument (balloon sheath with miniprobe) in ... | 2002 | 12143258 |
| activation of adrenal preganglionic neurons during autonomic dysreflexia in the chronic spinal cord-injured rat. | autonomic dysreflexia (ad) occurs in a majority of high paraplegic and quadriplegic patients and is particularly characterized by a paroxysmal hypertension elicited by somatic or visceral stimuli. we have previously shown that plasma adrenaline and noradrenaline levels were significantly increased during episodes of ad in the 30-day spinal cord-injured (sci) rats, suggesting the participation of adrenal catecholamines in the cardiovascular changes associated to ad. thus, adrenal sympathetic preg ... | 2002 | 12144050 |
| temperature control and recovery of bowel function after laparoscopic or laparotomic colorectal surgery in patients receiving combined epidural/general anesthesia and postoperative epidural analgesia. | we compared the effects of a laparoscopic (n = 23) versus laparotomic (n = 21) technique for major abdominal surgery on temperature control in 44 patients undergoing colorectal surgery during a combined epidural/general anesthesia. a thoracic epidural block up to t4 was induced with 6-10 ml of 0.75% ropivacaine; general anesthesia was induced with thiopental, fentanyl, and atracurium iv and maintained with isoflurane. core temperature was measured with a bladder probe and recorded every 15 min a ... | 2002 | 12145073 |
| [goseki classification in adenocarcinoma of the cardia]. | to assess an additional prognostic value of goseki histological classification to tnm staging system in adenocarcinoma of the cardia. | 2002 | 12145574 |
| expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: a multicentre immunohistochemical study in the asia-pacific region. | with ongoing efforts to target the epidermal growth factor receptor (egfr)-mediated tumour growth in the treatment of selected human malignancies, there is a need to determine the expression levels of egfr and to evaluate its prognostic value in various malignancies in the asia-pacific region. | 2002 | 12147092 |
| characterization of virus adsorption by using deae-sepharose and octyl-sepharoser. | viruses were characterized by their adsorption to deae-sepharose or by their elution from octyl-sepharose by using buffered solutions of sodium chloride with different ionic strengths. viruses whose adsorption to deae-sepharose was reduced most rapidly by an increase in the sodium chloride concentration were considered to have the weakest electrostatic interactions with the solids; these viruses included ms2, e1, and phix174. viruses whose adsorption to deae-sepharose was reduced least rapidly w ... | 2002 | 12147497 |
| resistance training improves strength and functional measures in patients with end-stage renal disease. | the current study was designed to examine the effect of 12 weeks of resistance training on strength and functional ability in 10 medically stable hemodialysis patients (age, 42.8 +/- 4.4 years). | 2002 | 12148109 |
| thyroid status of normal pregnant women in dhaka city. | the thyroid gland secretes thyroid hormones having important role in embryogenesis and fetal development during pregnancy. the present study was carried out to find out alteration in the thyroid size and serum thyroid hormonal levels (t4, t3 and tsh) in normal pregnant women as compared to non-pregnant women in dhaka city. for this purpose, thirty-five pregnant women during third trimester attending opd dhaka medical college hospital from january 1998 to july 1998 were selected randomly and twen ... | 2002 | 12148388 |
| selective neck dissection for the treatment of neck metastasis from squamous cell carcinoma of the head and neck. | our objective was to determine the proportion of patients disease free in the neck, with the primary site controlled, who have been treated with a selective neck dissection (snd) for squamous cell carcinoma (scca) of the upper aerodigestive tract, and who had cervical metastasis less than 3 cm. | 2002 | 12148849 |
| radical radiation for localized prostate cancer: local persistence of disease results in a late wave of metastases. | to assess whether failure to maintain local control (lc) of prostate cancer after radiation therapy results in a higher incidence of distant metastasis (dm). | 2002 | 12149291 |
| thyroid function and intellectual development of children of mothers taking methimazole during pregnancy. | there is some debate regarding the safety of methimazole (mmi) therapy during pregnancy. it is not known whether mmi therapy in mothers during pregnancy is safe for their children or if it causes alterations in thyroid function and intellectual development during childhood. twenty-three children, whose mothers were hyperthyroid during pregnancy and treated with mmi 5-20 mg were studied from age 3-11 yr. thyroid function and liver function tests, urinary iodine, anti-thyroid antibodies, intellige ... | 2002 | 12150331 |
| effects of excess thyroid hormone on cell death, cell proliferation, and new neuron incorporation in the adult zebra finch telencephalon. | widespread telencephalic neuronal replacement occurs throughout life in birds. we explored the potential relationship between thyroxine (t4) and cell turnover in the adult male zebra finch. we found that many cells in the zebra finch brain, including long-projection neurons in the high vocal center (hvc), stained positively with an antibody to thyroid hormone receptors (tr). labeling was generally weak in the ventricular zone (vz) that gives rise to new neurons but some proliferative vz cells an ... | 2002 | 12150507 |
| hypopharyngeal cancer: results of treatment based on radiation therapy and salvage surgery. | the purpose of this study is to present the treatment results and to identify possible prognostic indicators in patients with hypopharyngeal squamous cell carcinoma (hpc). | 2002 | 12150614 |
| prevalence of chronic lymphocytic thyroiditis in adolescent girls. | chronic lymphocytic thyroiditis (clt) is the most common cause of thyroid enlargement in children and adolescents in iodine sufficient areas. the prevalence and pattern of clt in adolescent girls in iodine deficient regions supplemented with iodine is as yet not known. we therefore, carried out clinical examination for the presence of goitre in 330 healthy girls from delhi in the age group of 16-20 years and those with goitre were further subjected to detailed biochemical (t3, t4, tsh), immunolo ... | 1998 | 12152841 |
| inducible nitric oxide synthase expression in pharyngeal squamous cell carcinoma: relation to p53 expression, clinicopathological data, and survival. | to investigate the expression of inducible nitric oxide synthase (inos) in oropharyngeal and hypopharyngeal squamous cell carcinoma (scc) and its relation to p53 expression, histologic differentiation, clinical data, and prognosis. | 2002 | 12160278 |
| trends in breast cancer aggressiveness before the introduction of mass screening in southeastern netherlands 1975-1989. | the increased incidence of breast cancer in the southeastern netherlands was accompanied by markedly improved relative survival and stable mortality. we investigated whether the average aggressiveness of tumors changed over time in a population-based study, before the introduction of mass screening. | 2002 | 12160325 |
| the effects of thyroxine or a gnrh analogue on thyroid hormone deiodination in the olfactory epithelium and retina of rainbow trout, oncorhynchus mykiss, and sockeye salmon, oncorhynchus nerka. | using low (0.5nm) substrate levels we determined the activities of thyroxine (t4) outer-ring deiodination (ord), t4 inner-ring deiodination (t4ird) and 3,5,3(')-triiodothyronine (t3) ird activities in the olfactory epithelium (olf) and retina (ret) of laboratory-held immature 1-year-old rainbow trout and immature 2.5-year-old sockeye salmon. in both species all three deiodination activities were detected in olf and ret. for olf, no particular pathway predominated and activities were similar to t ... | 2002 | 12161202 |
| [timing and duration of postoperative radiotherapy in patients with laryngeal cancer]. | aim of this was an evaluation of the impact of prolongation of combined treatment time on the local-regional control laryngeal cancer patients treated with surgery and postoperative radiotherapy. study was based on retrospective analysis of 254 patients with t3/t4 and n0-n2 laryngeal cancer who were treated between january 1993 and december 1996 with surgery and postoperative radiotherapy (rt). median age of investigated group was 56.3 years. surgery consisted of total laryngectomy in all cases ... | 2002 | 12162018 |
| [tonsillar carcinoma--clinical assessment and analysis of treatment results]. | the aim of the study was an evaluation of the clinical signs and treatment results of the patients with tonsillar cancer treated in the ent clinic medical university in łódź during 10 years (1985-1994). in this study we analysed retrospectively the data of 40 subjects (52% of all group 76 patients). twenty four patients (55%) had tumor with t3-t4 stage and 21 patients (52.5%)--palpable lymph neck nodes. the most frequent treatment modality was combined therapy (surgery with radio/chemotherapy) i ... | 2002 | 12162020 |
| localization and regulation of the growth hormone receptor and growth hormone-binding protein in the rat growth plate. | growth hormone (gh) has direct effects on the growth plate to stimulate longitudinal growth, but it is not clear which chondrocyte populations gh acts on. the dual effector theory suggests that gh would act primarily on the "stem cells." however, staining with a gh receptor (ghr) antibody is found in all layers of the growth plate in rabbits and humans. we now have investigated the localization and regulation of ghr and the related gh binding protein (ghbp) in the rat growth plate using a sensit ... | 2002 | 12162495 |
| prognostic significance of p21waf1/cip1 expression in tongue squamous cell carcinomas. | to investigate the prognostic significance of p21(waf1/cip1) expression and its relationship with p53 accumulation and other apoptotic markers such as bax, bcl-2, and apoptotic index in relation to disease-specific survival in oral tongue squamous cell carcinoma (scc). | 2002 | 12162767 |
| endocrine dismodulation and cancer. | carcinogenesis has generally been viewed as a genomic disease resulting from genetic mutations occurring at critical locations in the genome in a particular sequence. in the last 10 years, scientists have increasingly identified changes in the levels, frequency and types of endocrine hormones as important contributors to the major cancers faced by western populations such as breast cancer (estrogen, progesterone, prolactin), prostate cancer (estrogen, testosterone), endometrial cancer (estrogen) ... | 2002 | 12163847 |
| [biochemical control after conformal, 3 dimensional radiotherapy of prostatic carcinoma]. | to evaluate biochemical control after 3-d radiation therapy of prostate cancer. | 2002 | 12163991 |
| subclinical thyrotoxicosis and the heart. | subclinical thyrotoxicosis is defined as a below normal thyrotropin (tsh) in association with a normal total and free thyroxine (t4) and triiodothyronine (t3). it may be caused by thyroid hormone treatment or by endogenous thyroid disease. the degree of thyrotoxicosis may be estimated by the level of tsh suppression. subclinical thyrotoxicosis may be associated with changes in cardiac performance and morphology, but this has not been consistently found in all patient populations. changes may inc ... | 2002 | 12165112 |
| thyroid hormone metabolism in patients with congestive heart failure: the low triiodothyronine state. | thyroid hormone has multiple effects on the cardiovascular system, ranging from molecular and cellular effects to the consequent hemodynamic alterations. consequently, thyroid function has been evaluated in small cohorts of patients with advanced heart failure that indicate a significant prevalence of morphologic or functional thyroid disorders. we sought to determine the prevalence of altered thyroid hormone metabolism in a broad spectrum of ambulatory heart failure patients. thyroid function t ... | 2002 | 12165115 |
| influence of long term erythropoietin therapy on the hypothalamic-pituitary-thyroid axis in patients undergoing capd. | treatment of anemia with recombinant human erythropoietin (rhuepo) in hemodialysis patients has been associated with improvement of several abnormalities in hypothalamic-pituitary function. the aim of the present study is to investigate the effects of long term erythropoietin therapy on the hypothalamic-pituitary-thyroid hormone axis in patients undergoing continuous ambulatory peritoneal dialysis (capd). | 2002 | 12166698 |
| comparison of octreotide administration vs conservative treatment in the management of inoperable bowel obstruction in patients with far advanced cancer: a randomized, double- blind, controlled clinical trial. | conservative treatment of inoperable bowel obstruction in terminal cancer patients has been found to be effective in controlling the distressing symptoms caused by this complication. the purpose of this study was to evaluate the efficacy of octreotide in the management of nausea, vomiting and abdominal pain, secondary to bowel obstruction in terminally ill cancerpatients, when surgery was inappropriate. patients and | 2002 | 12168923 |
| radiation treatment of t1-t4 squamous cell carcinoma of the larynx: a retrospective analysis and long-term follow-up of 135 patients. | to evaluate the long-term outcome of radiation therapy for patients with histologically verified squamous cell glottic carcinoma. | 2002 | 12168932 |
| the acute phase response in breast carcinoma. | the acute phase response follows tissue injury, trauma or infection and maintains homeostasis. it may also be activated in patients with malignancy and studies have suggested that it is associated with a poor prognosis. this study examined c-reactive protein (crp) and serum amyloid a (saa) in patients with breast carcinoma, both at presentation and during follow-up, to assess the value of the acute phase proteins in patient management. | 2002 | 12168939 |
| preoperative staging by multidetector-row computed tomography in patients with rectal carcinoma. | multidetector-row computed tomography (mdct, or multi-slice ct) has been introduced in 2000. so far, there has been no published study on this modality in patients with rectal carcinoma. | 2002 | 12169356 |
| vertebroplasty in the mid- and upper thoracic spine. | vertebroplasty performed in the mid- and upper thoracic spine presents technical challenges that differ from those in the lower thoracic and lumbar region. we herein report results of percutaneous vertebroplasty for treatment of painful, osteoporotic compression fractures in the mid- and upper thoracic spine. | 2002 | 12169467 |
| extended local resection for advanced gastric cancer: increased survival versus increased morbidity. | to characterize factors predictive of improved survival following gastrectomy with additional organ resection for the treatment of gastric cancer. | 2002 | 12170020 |
| preoperative staging of colorectal cancer with a balloon-sheathed miniprobe. | conventional endoscopic ultrasonography (eus) is a valuable modality for staging the depth of invasion of colorectal cancer. however, there are difficulties with this technique in reaching as far as the cecal area, traversing tight strictures, and obtaining clear images of smaller lesions. due to these factors, mis-staging often occurs. the literature shows that the miniprobe is superior to eus, because of its easy manipulation and better diagnostic accuracy. we therefore conducted a prospective ... | 2002 | 12170411 |
| prognostic value of microsatellite instability in resectable pancreatic cancer. | the significance of microsatellite instability (msi) as a prognostic predictor for resectable pancreatic cancer patients was examined. forty-six histologically confirmed pancreatic cancer patients who had undergone resection were studied. dna was extracted from the paraffin block sections by means of the microdissection method. pcr was performed using eight microsatellite primer marker sets. the mixed pcr sample was analyzed by a genetic analyzer. the number of msi-positive patients was eight (1 ... | 2002 | 12171881 |
| effects of methylprednisolone and dextromethorphan on lipid peroxidation in an experimental model of spinal cord injury. | this study examines the effects of agents purported to improve recovery following spinal cord trauma, methylprednisolone sodium succinate, dextromethorphan, and the combination of both, on the post-traumatic alterations of membrane lipid metabolism. | 2002 | 12172735 |
| estramustine phosphate combined with orchidectomy as first-line therapy in patients with prostate carcinoma. effect of age on survival. | the role of age as a prognostic factor for survival remains debatable in patients with prostate carcinoma. | 2002 | 12173326 |
| multivisceral resection for colon cancer. | there is a lack of appropriate information in regard to the optimal treatment for colon cancer infiltrating neighboring organs. | 2002 | 12173378 |
| [detection of dna packing density in bacteriophages phi kz and t4 by atomic force microscopy]. | comparative analysis of dna packing density in phi kz and t4 bacteriophages was carried out by atomic force microscopy. irrespective of the support (mica or highly ordered pyrrolytic graphite), phi kz bacteriophage was compressed stronger than t4. the most probable causes of this difference are analyzed. | 2002 | 12173433 |
| transforming growth factor-beta1 in invasion and metastasis in colorectal cancer. | to investigate the role of tgfbeta1 in invasion and metastasis in colorectal cancer by analysing tgfbeta1 correlated with depth of tumor invasion, stage and metastasis. | 2002 | 12174377 |
| [a clinical study of 213 patients with laryngeal cancer]. | we retrospectively analyzed 213 patients--197 men and 14 women aged 40 to 87 years--with laryngeal cancer treated at our department from september 1986 to december 1997. the male to female ratio was about 12:1. cases included 120 glottic (56.3%), 90 supraglottic (42.3%), and 3 subglottic (1.4%). radiotherapy for early cases and surgery, mainly total laryngectomy for t3 and t4 were conducted first. the 5-year cause-specific survival by site was 97.6% glottic and 77.5% supraglottic. the five-year ... | 2002 | 12174612 |
| quantitative thyroid scintigraphy as a predictor of serum thyroxin concentration in normal and hyperthyroid cats. | quantitative thyroid scintigraphy using pertechnetate was performed in 43 cats with various t4 concentrations and compared to eight normal control cats. quantitative parameters included percentage dose uptake of the radioisotope by the thyroid, thyroid:salivary ratio and rate of thyroid uptake. all cats were anesthetized for the scan, and images were obtained using both low-energy all purpose (leap) and pinhole collimators. all quantitative parameters were significantly correlated to the serum t ... | 2002 | 12175003 |
| immunohistochemical detection of the 150-kda oxygen-regulated protein in bladder cancer. | to investigate the relationship between the expression of the 150-kda oxygen-regulated protein (orp150, which functions as a molecular chaperone in the endoplasmic reticulum for the folding and trafficking of newly synthesized proteins) and the aggressiveness of bladder cancer, and the expression of vascular endothelial growth factor (vegf) and matrix metalloproteinases (mmps), as the former is a secreting protein through the endoplasmic reticulum and the latter are closely involved in tumour in ... | 2002 | 12175409 |
| genomic imprinting contributes to thyroid hormone metabolism in the mouse embryo. | many genes subject to genomic imprinting function in a number of endocrine/paracrine pathways that are important for normal mammalian development. here, we show that an endocrine/paracrine pathway involving thyroid hormone metabolism is also regulated by imprinting. thyroid hormone action depends on thyroid hormone receptors and their predominant ligand, 3,5,3'-triiodothyronine (t3). in vivo, thyroid hormone levels are maintained within the physiological range through the interaction of three io ... | 2002 | 12176332 |
| molecular and physiological differentiation between pathogenic and nonpathogenic acanthamoeba. | in this study, 14 isolates of acanthamoeba from both clinical and environmental sources belonging to seven different species were assayed for tolerance of high osmotic pressure, temperature tolerance, extracellular proteases, and cytopathic effects (cpe) on immortalized rabbit corneal epithelial cells. on the basis of the results, amoeba isolates were divided into pathogenic and nonpathogenic groups. ribosomal dna sequencing was performed on these isolates. phylogenetic relationships revealed th ... | 2002 | 12177742 |
| [extracorporeal shock wave lithotripsy and recurrent urolithiasis]. | changes in concentrations of total thyroxine (t4) and triiodothyronine (t3) in blood plasma, blood coagulation and prothrombin index (pi) 9 days after exposure to extracorporeal shock-wave lithotripsy (eswl) were studied in patients with urolithiasis. urolithiasis patients with chronic pyelonephritis running with non-severe renal pain had often elevated concentrations of t3, t4 and blood coagulation. on day 9 after eswl plasma concentration of t3 and coagulation decreased while t4 concentration ... | 2002 | 12180058 |
| differential expression of bcl-2 family proteins in bladder carcinomas. relationship with apoptotic rate and survival. | to elucidate the role of various bcl-2 family molecules in the regulation of apoptosis and the progression of urothelial cancer, in relation to standard prognosticators. | 2002 | 12180228 |
| pharmacodynamics and atracurium and laudanosine concentrations during a fixed continuous infusion of atracurium in mechanically ventilated patients with acute respiratory distress syndrome. | the present study was designed to assess the pharmacodynamics and the plasma levels of atracurium and laudanosine found during a 72-hour fixed rate infusion of atracurium in acute respiratory distress syndrome patients without renal or liver failure. nine sedated and mechanically ventilated acute respiratory distress syndrome patients without renal or liver failure were paralysed with a bolus of atracurium (1 mg x kg(-1)) followed by a 72-hour continuous infusion (1 mg x kg(-1) x h(-1)). the cou ... | 2002 | 12180578 |
| sexual dimorphic expression of adh in rat liver: importance of the hypothalamic-pituitary-liver axis. | hepatic alcohol dehydrogenase (adh) activity is higher in female than in male rats. although sex steroids, thyroid, and growth hormone (gh) have been shown to regulate hepatic adh, the mechanism(s) for sexual dimorphic expression is unclear. we tested the possibility that the gh secretory pattern determined differential expression of adh. gonadectomized and hypophysectomized male and female rats were examined. hepatic adh activity was 2.1-fold greater in females. because protein and mrna content ... | 2002 | 12181179 |
| a dominant-negative mutant of human dna helicase b blocks the onset of chromosomal dna replication. | a cdna encoding a human ortholog of mouse dna helicase b, which may play a role in dna replication, has been cloned and expressed as a recombinant protein. the predicted human dna helicase b (hdhb) protein contains conserved helicase motifs (superfamily 1) that are strikingly similar to those of bacterial recd and t4 dda proteins. the hdhb gene is expressed at low levels in liver, spleen, kidney, and brain and at higher levels in testis and thymus. purified recombinant hdhb hydrolyzed atp and da ... | 2002 | 12181327 |
| [current views on diagnostic standards and treatments with l-thyroxine of single non-toxic thyroid nodules or multinodular non-toxic goiter]. | the present opinions on the therapy with l-thyroxine (l-t4) of single non-toxic thyroid nodules, as well as of multinodular non-toxic goitre are rather divergent. this treatment is based on the suppression of tsh secretion from the pituitary. there are no doubts that fnab performance is the first and--at the same time--the most significant diagnostic procedure in the case of thyroid structural lesions (nodules, goitre, thyroiditis). fnab performance should--by all means--precede the beginning of ... | 2001 | 12182027 |
| [early evaluation of results after total thyroidectomy in patients with thyroid cancer]. | 219 patients (159 females, 60 males) operated in clinic of oncological surgery in gliwice between 1995 and 1999 were analyzed in this study. in 89% of cases differentiated thyroid carcinoma (dtc) was diagnosed. in other patients medullary cancer (8%) and anaplastic one (3%) were diagnosed. total thyroidectomy with removal of the central cervical lymph nodes compartment was performed in all cases. in 86% of operations bilateral nodal biopsy was done. in 27% of cases modified cervical lymph node d ... | 2001 | 12182028 |
| drug-induced and postnatal hypothyroidism impairs the accumulation of diacylglycerol in liver and liver cell plasma membranes. | thyroid hormones are well known modulators of signal transduction. the effect of hyper- and hypo-thyroidism on diacylglycerol/protein kinase c (dag/pkc) signaling in cardiomiocytes has been determined. triiodothyronine (t3) has been shown to prevent the alpha1-adrenoreceptor-mediated activation of pkc but does not alter the stimulation of enzyme and hepatic metabolism by phorbol ethers. it has been suggested that the elevation of endogenous dag in senescent or hypothyroid cells changes the pkc-d ... | 2002 | 12182762 |
| dose escalation using twice-daily radiotherapy for nasopharyngeal carcinoma: does heavier dosing result in a happier ending? | to present our experience using a twice-daily radiotherapy (rt) technique, including hyperfractionated and accelerated-hyperfractionated rt, on nasopharyngeal carcinoma (npc) patients. the dose to the primary tumor was increased in the hope that local control could be increased without the cost of increased late complications. we analyzed acute and late complications and local control and compared the results with the results of npc patients treated during the same period using conventional once ... | 2002 | 12182970 |
| [effect of blanching and hygroscopic coating on quality of fresh cut carrots (daucus carota var. chantenay) during storage]. | the effect of blanching at low temperatures (solution 1% acid citric, 50 degrees c for 30 seconds) and the application of glycerol as humectant (3% p/p, 20 seconds) to preserve the quality of fresh-cut carrots (daucus carota) were studied as individual or combined treatments. four treatments were evaluated: a control by dipping samples for 30 seconds in distilled water (t1); blanching (t2); glycerol application (t3); and blanching plus glycerol application (t4). total carotenoids content, color, ... | 2002 | 12184154 |
| burden of organochlorine pesticides in blood and its effect on thyroid hormones in women. | man has utilized a wide variety of pesticides to combat the crop pests and vectors of human diseases. however, in this process, he has overlooked the darker side of these noxious chemicals, the concentrations of which have reached the environment and pose serious threats, such as mutagenesis, teratogenesis, carcinogenesis and endocrine dysfunction in various components of the ecosystem. the present study was planned to assess the burden of organochlorine pesticides and their influence on thyroid ... | 2002 | 12186288 |
| iodine deficiency in azerbaijan after the discontinuation of an iodine prophylaxis program: reassessment of iodine intake and goiter prevalence in schoolchildren. | the goal of this study was to assess the prevalence of iodine deficiency (id) in azerbaijan after the discontinuation of an iodine prophylaxis program by assessing the prevalence of goiter, iodine intake, and thyroid function. the study included 942 schoolchildren (475 boys and 467 girls) ages 8-14 years, from 13 distinct regions. the survey included the following: (1) clinical evaluation; (2) assessment of thyroid volume both by ultrasound and by palpation; (3) determination of iodide in a morn ... | 2001 | 12186501 |
| using 2-aminopurine fluorescence to measure incorporation of incorrect nucleotides by wild type and mutant bacteriophage t4 dna polymerases. | the ability of wild type and mutant t4 dna polymerases to discriminate in the utilization of the base analog 2-aminopurine (2ap) and the fluorescence of 2ap were used to determine how dna polymerases distinguish between correct and incorrect nucleotides. because t4 dna polymerase incorporates dtmp opposite 2ap under single-turnover conditions, it was possible to compare directly the kinetic parameters for incorporation of dtmp opposite template 2ap to the parameters for incorporation of dtmp opp ... | 2002 | 12189135 |
| mechanism of chaperone function in small heat shock proteins. two-mode binding of the excited states of t4 lysozyme mutants by alphaa-crystallin. | to elucidate the mechanism of alphaa-crystallin chaperone function, a detailed thermodynamic analysis of its binding to destabilized, site-directed mutants of t4 lysozyme was carried out. the selected mutants form a ladder of stabilities spanning the 5-10 kcal/mol range of free energy of unfolding. the crystal structures of the majority of the mutants have been previously determined and found to be similar to that of the wild type with no evidence of static local unfolding. complex formation bet ... | 2002 | 12189146 |
| bacteriophage-encoded cochaperonins can substitute for escherichia coli's essential groes protein. | the escherichia coli chaperonin machine is composed of two members, groel and groes. the groel chaperonin can bind 10-15% of e. coli's unfolded proteins in one of its central cavities and help them fold in cooperation with the groes cochaperonin. both proteins are absolutely essential for bacterial growth. several large, lytic bacteriophages, such as t4 and rb49, use the host-encoded groel in conjunction with their own bacteriophage-encoded cochaperonin for the correct assembly of their major ca ... | 2002 | 12189177 |
| [some peculiarities of dna structure of cyanophage lpp-3]. | the efficiency of radioactive labeling of 3'- and 5'-ends of cyanophage lpp-3 dna by polynucleotide kinase t4 and terminal transferase under various reaction conditions has been investigated. the obtained data prove that cyanophage lpp-3 dna has the protruding 3'-ends. the experiments on ligation of native molecules of lpp-3 dna evidence that the virus genome ends do not display any complimentarity. separate fragments of lpp-3 dna were cloned. the restriction analysis of the cloned fragments has ... | 2002 | 12190023 |
| the influence of successful prophylactic drug treatment on cognitive dysfunction in bipolar disorders. | cognitive variables such as negative self-evaluations have been discussed as vulnerability factors for depressive syndromes. in the context of bipolar disorders dysfunctional cognitive structures have received little interest as these patients seem to be less disturbed during the euthymic interval than patients with major depression. | 2002 | 12190716 |
| hormone profile of kuwaiti women with hyperemesis gravidarum. | to evaluate the incidence of hyperemesis gravidarum among pregnant women in kuwait and the status of hcg, tsh, total t4 and free t4 in the serum of patients with hyperemesis gravidarum compared with a control group of women. | 2002 | 12192483 |
| carbon-11 tyrosine pet for visualization and protein synthesis rate assessment of laryngeal and hypopharyngeal carcinomas. | accurate assessment of tumour extent and lymph node involvement in squamous cell carcinomas of the head and neck region is essential for therapy planning. unfortunately, conventional diagnostic examination and imaging techniques, which monitor tumours on the basis of anatomical parameters, have drawbacks in clinical practice. the aim of this study was to investigate the feasibility of l-[1-(11)c]-tyrosine (tyr) positron emission tomography (pet) for visualisation of squamous cell carcinoma of th ... | 2002 | 12192563 |