| involvement of level i neck lymph nodes in advanced squamous carcinoma of the larynx. | this study was performed to evaluate the incidence of metastasis at level i in patients with squamous laryngeal cancer. one hundred consecutive patients with squamous carcinoma of the larynx were submitted to surgical treatment including radical neck dissection. the tumor stage was t3 or t4, and the neck stage was n1-n2c. lymph node metastases were pathologically confirmed in 80 patients. metastases were concentrated within level ii in 59% of cases, level iii in 17% of cases, level iv in 11% of ... | 2001 | 11642434 |
| [screening for thyroid disease. occurrence of hypothyroidism and hyperthyroidism in patients admitted to a geriatric department]. | the aim of this study was to evaluate whether screening of all geriatric patients for thyroid disorders should be recommended and to assess the prevalence of thyroid dysfunction in a geriatric population. | 2001 | 11665469 |
| intrathecal baclofen for generalized dystonia. | the aim of this study was to evaluate the effects of intrathecal bacolfen (itb) on patients with severe generalized dystonia. eighty-six participants ranging in age from 3 to 42 years (median age 13 years) with generalized dystonia refractory to oral medications were offered treatment with itb. dystonia was associated with cerebral palsy in 71% of participants. response to itb was tested by continuous infusions in 72%, and by bolus injections in 17% of participants who had both dystonia and spas ... | 2001 | 11665821 |
| identification of a novel truncated isoform of trkb in the kitten primary visual cortex. | neurotrophins have been shown to play important roles in development and plasticity of the visual cortex (vc). since signal transduction of neurotrophins is mediated through neurotrophin receptors, we attempted to analyze neurotrophin receptors in the vc. in this study, we isolated cdnas encoding the intracellular regions of truncated isoforms of the trkb receptor from 30-d-old kitten primary vc. two distinct truncated isoforms of trkb were isolated and characterized by sequence analyses. one of ... | 2001 | 11665865 |
| endoscopic thoracic sympathetic block by clipping for palmar and axillary hyperhidrosis in children and adolescents. | endoscopic thoracic sympathectomy or sympathicotomy is a safe and effective method of treating primary hyperhidrosis (ph), but postoperative compensatory sweating may be a problem. there are few reports of sympathetic blockade by clipping for ph. we present our experience of endoscopic thoracic sympathetic block (etsb) by clipping in treating palmar (pah) and axillary hyperhidrosis (ah) in children and adolescents. between may 1997 and june 1998, a total of 78 patients with pah or ah underwent e ... | 2001 | 11666053 |
| mercury(ii) site-selective binding to a dna hairpin. relationship of sequence-dependent intra- and interstrand cross-linking to the hairpin-duplex conformational transition. | hg(ii) interacted site selectively with only one of three deoxyribooligonucleotides examined; these "oligos" each had a different number of unmatched t residues. thus, hg(ii) formed an intrastrand t-hg-t cross-link between the first and fourth t residues of the hairpin, d(gcgcttttgcgc) (t4). the dna strand formed a loop around the hg, as if the hg atom had been lassoed. the interactions of hg(ii) with two other oligos, d(atgggttcccat) (t2) and d(gcgctttgcgc) (t3), were less specific. previously, ... | 1996 | 11666759 |
| inhibitory effects of calcium channel blockers on thyroid hormone uptake in neonatal rat cardiomyocytes. | the effects of the ca2+ channel blockers verapamil, nifedipine, and diltiazem on triiodothyronine (t3) and thyroxine (t4) uptake were tested in cultured cardiomyocytes from 2-day-old rats. experiments were performed at 37 degrees c in medium with 0.5% bsa for [125i]t3 (100 pm) or 0.1% bsa for [125i]t4 (350 pm). the 15-min uptake of [125i]t3 was 0.124 +/- 0.013 fmol/pm free t3 (n = 6); [125i]t4 uptake was 0.032 +/- 0.003 fmol/pm free t4 (n = 12). neither t3 nor t4 uptake was affected by 1% dmso ( ... | 2001 | 11668059 |
| skeletal and dento-alveolar stability after surgical-orthodontic treatment of anterior open bite: a retrospective study. | the aim of this investigation was to assess skeletal and dento-alveolar stability after surgical-orthodontic correction of skeletal anterior open bite treated by maxillary intrusion (group a) versus extrusion (group b). the cephalometric records of 49 adult anterior open bite patients (group a: n = 38, group b: n = 11), treated by the same maxillofacial surgeon, were examined at different timepoints, i.e. at the start of the orthodontic treatment (t1), before surgery (t2), immediately after surg ... | 2001 | 11668874 |
| serotypes and phage types of vibrio cholerae in mysore. | a total of 565 samples of acute diarrhoeal stools from children received over a period of twelve months from november 1996 to october 1997, yielded 289 (51.15%) isolates of v. cholerae. out of these, 277 (95.85%) were v. cholerae 01 serotype ogawa, 7 (2.42%) were v. cholerae 0139 and 5 (1.73%) were v. cholerae non-o1 non-0139. phage typing of the isolates was carried out by niced calcutta. out of 78 isolates, 69 (88.46%) belong to phage type t27. of the remaining, 3 (3.85%), 3(3.85%), 2(2.56%) a ... | 2000 | 11668944 |
| sphincter preservation after short-term preoperative radiotherapy for low rectal cancer--presentation of own data and a literature review. | this report is based on a series of 108 patients with clinically staged t2 (9), t3 (94) and t4 (5) rectal cancer treated with preoperative irradiation with 25 gy, 5 gy per fraction given for one week. in 77% of patients. the tumour was located within 7 cm of the anal verge and in 15% the anal canal was involved. surgery was usually undertaken during the week after irradiation. for low tumours, total mesorectal excision was performed, and for middle and upper cancers, the whole circumference of t ... | 2001 | 11669331 |
| physical properties of human polynucleotide kinase: hydrodynamic and spectroscopic studies. | human polynucleotide kinase (hpnk) is a putative dna repair enzyme in the base excision repair pathway required for processing and rejoining strand-break termini. this study represents the first systematic examination of the physical properties of this enzyme. the protein was produced in escherichia coli as a his-tagged protein, and the purified recombinant protein exhibited both the kinase and the phosphatase activities. the predicted relative molecular mass (m(r)) of the 521 amino acid polypep ... | 2001 | 11669634 |
| ru(phen)(2)dppz(2+) luminescence: dependence on dna sequences and groove-binding agents. | emission of delta-ru(phen)(2)dppz(2+) bound to nucleic acid polymers of different sequence has been investigated by time-resolved luminescence spectroscopy and the effect of major and minor groove dna binding agents on the luminescence profile of the complex evaluated. in the presence of a 1:1 mixture of poly d(at) and poly d(gc), the excited-state decay of delta-ru(phen)(2)dppz(2+) can be described by a linear combination of the decay profiles in the presence of poly d(at) and poly d(gc) indepe ... | 1998 | 11670256 |
| proteolytic sensitivity and helper t-cell epitope immunodominance associated with the mobile loop in hsp10s. | antigen three-dimensional structure potentially limits antigen processing and presentation to helper t-cell epitopes. the association of helper t-cell epitopes with the mobile loop in hsp10s from mycobacteria and bacteriophage t4 suggests that the mobile loop facilitates proteolytic processing and presentation of adjacent sequences. sites of initial proteolytic cleavage were mapped in divergent hsp10s after treatment with a variety of proteases including cathepsin s. each protease preferentially ... | 2002 | 11673463 |
| off-pump versus on-pump coronary artery bypass grafting: oxidative stress and renal function. | oxidative stress and renal dysfunction occur in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass (on-pump cabg). whether the same adverse effects also occur during off-pump cabg is the question in this study. | 2001 | 11675176 |
| [brain metastases from esophageal cancers: clinical features and treatment results]. | metastatic brain tumors from esophageal cancer are relatively rare. we analyzed the clinical features and results of treatment in 14 cases of brain metastases from esophageal carcinoma. the average time to diagnosis of brain metastases in the 11 patients with metachronous lesions was 13 months. the average age of patients at the diagnosis of brain metastasis was 65 years. most patients had t4 or n1 disease at the time of diagnosis of esophageal cancer. performance status of grade 3 was most freq ... | 2001 | 11676170 |
| characterization and mapping of dna damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (nnk) at nucleotide resolution in human genomic dna. | the nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (nnk) is an important tobacco-specific carcinogen associated with lung cancer. its complex enzymatic activation, leading to methyl and pyridyloxobutyl (pob)-modified dna, makes dna damage difficult to characterize and quantify. therefore, we use the nnk analogue 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone (nnkoac) to induce damage in genomic dna, and to map the sites and frequency of adducts at nucleotide resolution using ... | 2001 | 11676538 |
| oxygen free radical damage to dna. translesion synthesis by human dna polymerase eta and resistance to exonuclease action at cyclopurine deoxynucleoside residues. | cyclopurine deoxynucleosides are common dna lesions generated by exposure to reactive oxygen species under hypoxic conditions. the s and r diastereoisomers of cyclodeoxyadenosine on dna were investigated separately for their ability to block 3' to 5' exonucleases. the mammalian dna-editing enzyme dnase iii (trex1) was blocked by both diastereoisomers, whereas only the s diastereoisomer was highly efficient in preventing digestion by the exonuclease function of t4 dna polymerase. digestion in bot ... | 2001 | 11677235 |
| the effect of methimazole on thyroid uptake of pertechnetate and radioiodine in normal cats. | many hyperthyroid cats referred for thyroid imaging and 131i therapy are concurrently or recently receiving antithyroid medications. the effect of the antithyroid drug, methimazole, on thyroid uptake of 99mtco4 and 123i was evaluated in 8 normal cats. quantitative analysis was used to determine the normal percent dose uptake of 99mtco4 and 123i, the change in thyroid:salivary ratios (t:s) of 99-tco4 over time, and the duration of the methimazole effect on thyroid uptake of 123i. methimazole was ... | 2001 | 11678569 |
| thyroid function in the newborn in relation to maternal thyroid status during labour in a mild iodine deficiency endemic area in sudan. | data on neonatal and maternal thyroid function during labour in a mild iodine deficiency endemic area are lacking. the current study focuses on elucidating the thyroid function during labour, in a group of pregnant women who live in an area of mild iodine deficiency in sudan compared to that observed in their corresponding newborns. | 2001 | 11678831 |
| long-term follow-up of contralateral lobe in patients hemithyroidectomized for solitary follicular adenoma. | since there are no available conclusive studies on the long-term evolution of remnant thyroid tissue after hemithyroidectomy in patients who undergo surgery for solitary follicular adenomas, we searched for such cases in our records to elucidate this issue. | 2001 | 11678834 |
| practical approach to patients presenting with multiple synchronous suspect lung lesions: a reflection on the current tnm classification based on 54 cases with complete follow-up. | to examine the survival after surgical treatment of patients presenting with two synchronous suspect lung lesions, and to reflect on the recent tnm classification, which has upgraded patients with two malignant lung lesions of the same histology into the t4 (both lesions in the same ipsilateral lobe) or m1 (different lobes or lungs) category. | 2001 | 11679175 |
| comparison of hydro-us and spiral ct in the staging of gastric cancer. | the purpose of this study was to compare the diagnostic accuracy of hydro-ultrasonography (us) and spiral computed tomography (ct) in the staging of gastric cancer. forty-three patients with gastric cancers confirmed at surgery underwent hydro-us and spiral ct on the same day prospectively. hydro-us and spiral ct were done after ingestion of water. us and ct images were independently analyzed. after surgery, pathological findings according to tnm classification were compared with us and ct findi ... | 2001 | 11679225 |
| in vivo accuracy of thoracic pedicle screws. | a retrospective observational study of 279 transpedicular thoracic screws using postoperative computed tomography (ct). | 2001 | 11679819 |
| [surgical strategy in rectosigmoidal cancer]. | colorectal cancer is frequent and diagnosed earlier thanks to the screening and to the progresses in the preoperative assessment. the precocity of the surgical resection takes advantage from the complete resection of vascular and nodes involvement. the rectal localisation of the cancer requires to take the reconstruction into account. if preoperative radiotherapy is helpful in t4 and t3 n2 and locally advanced tumour, the surgeon should consider the four approaches of rectal cancer: the anterior ... | 2001 | 11680177 |
| children with non-verbal learning disabilities (nld): coherence values in the resting state may reflect hypofunctional long distance connections in the right hemisphere. | eeg intrahemispheric coherences (hcohs) in the resting state in twenty-four 4 hz frequency windows between 1 and 51 hz were studied in 18 children with "non-verbal learning disorder" (nld) and compared to a group of 18 children with "verbal learning disorder" (vld). new facts were found in the nld group. these concern hemispheric balance, expressed as left minus right (l-r) homologous hcohs: 1a). in the high frequencies (25-51 hz) the number of long-distance hcohs, higher in the right hemisphere ... | 2001 | 11680298 |
| [survival benefits of and indications for extended surgery for advanced gastric cancer]. | the surgical management of locally advanced gastric cancer remains controversial. it is also unclear whether the postoperative survival rate could be improved by extended lymph node dissection. the aim of this paper is to determine the survival benefit of and the indications for extended surgery. lymph node metastasis in the paraaortic area frequently occurs in locally advanced cardiac cancer. in our previous studies, the paraaortic lymph nodes above and below the left renal vein were confirmed ... | 2001 | 11681003 |
| differential expression of na:k:2cl cotransporter, glucose transporter 1, and aquaporin 1 in freshly isolated and cultured bovine corneal tissues. | little is known about whether culturing corneal limiting layers causes changes in the expression of their membrane transporter proteins from those present in fresh tissues. accordingly, we compared mrna abundance of three well-described types of transporters: water channel aquaporin 1 (aqp1), glucose transporter (glut1), and na:k:2cl cotransporter (nkcc), as well as nkcc protein levels in fresh bovine corneal epithelium and endothelium with those in their cultured counterparts. abundance of mrna ... | 2001 | 11682698 |
| bone mineral density in male patients with l-thyroxine suppressive therapy and graves disease. | little is known about the effects of thyroid hormone excess in male patients. our aim was to evaluate bone mineral density (bmd), bone turnover markers, and thyroid function in male patients with treated thyroid cancer on long-term suppressive l-t4 therapy (tc) and in male patients with graves' disease (gd). we studied 49 male patients (aged 45+/-12 years), 17 with tc (29-288 months on l-t4 suppressive therapy; free t4: 1.9+/-0.6 ng/dl [normal< or =2.0]; tsh: 0.2+/-0.3 microu/ml [normal 0.5-5.0] ... | 2001 | 11683428 |
| selenium, selenoproteins and human health: a review. | selenium is of fundamental importance to human health. it is an essential component of several major metabolic pathways, including thyroid hormone metabolism, antioxidant defence systems, and immune function. the decline in blood selenium concentration in the uk and other european union countries has therefore several potential public health implications, particularly in relation to the chronic disease prevalence of the western world such as cancer and cardiovascular disease. ten years have elap ... | 2001 | 11683552 |
| intraoperative epidural blockade prevents the increase in protein breakdown after abdominal surgery. | the aim of this study was to investigate the effect of epidural blockade with bupivacaine, restricted to the intraoperative period, on protein catabolism after major abdominal surgery. | 2001 | 11683666 |
| upper tract transitional cell carcinoma following cystectomy for bladder cancer. | we assessed the incidence of upper urinary tract tumors (uutts) after cystectomy for invasive or superficial transitional cell carcinoma (tcc) of the bladder. the risk factors, patients' characteristics and evolution of those who developed uutts are analyzed. | 2001 | 11684849 |
| preoperative radiochemotherapy and sphincter-saving resection for t3 carcinomas of the lower third of the rectum. | to evaluate the complications and oncologic and functional results of preoperative radiochemotherapy and sphincter-saving resection for t3 cancers of the lower third of the rectum. | 2001 | 11685026 |
| studying excited states of proteins by nmr spectroscopy. | protein structure is inherently dynamic, with function often predicated on excursions from low to higher energy conformations. for example, x-ray studies of a cavity mutant of t4 lysozyme, l99a, show that the cavity is sterically inaccessible to ligand, yet the protein is able to bind substituted benzenes rapidly. we have used novel relaxation dispersion nmr techniques to kinetically and thermodynamically characterize a transition between a highly populated (97%, 25 degrees c) ground state confo ... | 2001 | 11685237 |
| autonomic dysreflexia and primary afferent sprouting after clip-compression injury of the rat spinal cord. | spinal cord injury leads to many forms of autonomic dysfunction including autonomic dysreflexia, a condition involving recurrent episodes of paroxysmal hypertension and associated bradycardia. this hypertension may reach intensities that are life-threatening. we investigated autonomic dysreflexia and the sprouting of central processes of primary afferent neurons (a potential mechanism for autonomic dysreflexia) in a clinically-relevant calibrated clip-compression model of spinal cord injury in t ... | 2001 | 11686496 |
| bacteriophage t4 dam dna-[n6-adenine]methyltransferase. kinetic evidence for a catalytically essential conformational change in the ternary complex. | we carried out a steady state kinetic analysis of the bacteriophage t4 dna-[n6-adenine]methyltransferase (t4 dam) mediated methyl group transfer reaction from s-adenosyl-l-methionine (adomet) to ade in the palindromic recognition sequence, gatc, of a 20-mer oligonucleotide duplex. product inhibition patterns were consistent with a steady state-ordered bi-bi mechanism in which the order of substrate binding and product (methylated dna, dna(me) and s-adenosyl-l-homocysteine, adohcy) release was ad ... | 2002 | 11687585 |
| kinetic mechanism of the mg2+-dependent nucleotidyl transfer catalyzed by t4 dna and rna ligases. | the mg(2+)-dependent adenylylation of the t4 dna and rna ligases was studied in the absence of a dna substrate using transient optical absorbance and fluorescence spectroscopy. the concentrations of mg(2+), atp, and pyrophosphate were systematically varied, and the results led to the conclusion that the nucleotidyl transfer proceeds according to a two-metal ion mechanism. according to this mechanism, only the di-magnesium-coordinated form mg(2)atp(0) reacts with the enzyme forming the covalent c ... | 2002 | 11687591 |
| t2 tumors larger than five centimeters in diameter can be upgraded to t3 in non-small cell lung cancer. | among the tnm criteria, tumor size is a well-assessed factor in the prognosis of small tumors. a 3-cm cutoff point separates t1 from t2 tumors, whereas a size larger than 3 cm is not ascribed any prognostic value. instead, n2 is considered to be the worst prognostic factor for intrathoracic extended disease. | 2001 | 11689795 |
| [indications for preoperative laparoscopic ultrasonography]. | 109 laparoscopic ultrasound examinations are performed for a period of 7 years (1993-1999). laparoscope r. wolf and 7.5 mhz linear probe "aloka" are used. on the basis of the results analysis the following indications for laparoscopic ultrasonography (lus) are recommended: 1. uncertain diagnosis; 2. contradictory results of imaging technics; 3. assessment of tumour's stage; 4. early diagnosis; 5. negative data for liver lesion on laparoscopic examination and established or suspected tumour by im ... | 2000 | 11692932 |
| triiodothyronine concomitantly inhibits calcium overload and postischemic myocardial stunning in diabetic rats. | acute effects of triiodothyronine (t3) on postischemic myocardial stunning and intracellular ca2+ contents were studied in the isolated working hearts of streptozotocin-induced diabetic rats and age-matched controls. after two weeks of diabetes, serum t3 and t4 levels were decreased to 62.5% and 33.9% of control values. basal preischemic cardiac performance did not differ between diabetic and control rats. in contrast, during reperfusion after 20-min ischemia, diabetic rats exhibited an impaired ... | 2001 | 11693271 |
| morphological and functional differentiation of human thyroid cells in collagen gel culture. | cultured human thyroid cells in collagen gel culture were examined on cell morphology and the production of thyroglobulin (tg), triiodothyronine (t3) and thyroxine (t4) which are components of functional differentiation. | 2001 | 11694378 |
| unmasking of childhood hypothyroidism by disseminated xanthomas. | secondary hyperlipidemia is a common laboratory finding in children with nephrotic syndrome, diabetes mellitus, and hypothyroidism. however, clinical signs of hyperlipidemia are extremely rare in childhood. we report on an 11-year-old girl who presented with a disseminated yellow papulomatous rash on the lower limbs and yellow skin creases on the palms of her hands. blood tests yielded an opaque serum with a triglyceride concentration of 820 mg/dl and cholesterol of 1050 mg/dl. skin biopsy of on ... | 2001 | 11694680 |
| effects of dioxins and polychlorinated biphenyls (pcbs) on thyroid function in infants born in japan--the second report from research on environmental health. | dioxins (pcdd + pcdf) and polychlorinated biphenyl (pcb) are potentially hazardous compounds and have structural similarity to thyroid hormones. our research group on "dioxins and pcb in human milk" was organized in 1997 and has been active for the past three years. we collected breast milk from 80 mothers living in tokyo, saitama, ishikawa and osaka prefecture in japan at 5, 30, 150, 300 postpartum days and measured pcdds, pcdfs and pcbs during 1998-1999. we added another 20 prefectures and cit ... | 2001 | 11695630 |
| endoscopic t4-sympathetic block by clamping (esb4) in treatment of hyperhidrosis palmaris et axillaris--experiences of 165 cases. | prevention of postoperative complications becomes relatively important when surgical procedures are easy to learn and perform. endoscopic thoracic sympathetic surgery (ets), which is now more accessible to surgeons after the 2nd international symposium of thoracic sympathicotomy, would be the typical examples in surgery. reflex sweating is one of the famous and annoying complications that surgeons endeavor to avoid but in vain in ets. incidentally, we found that preservation of sympathetic tone ... | 2001 | 11695785 |
| efficacy and safety of thoracoscopic sympathicotomy for hyperhidrosis of the upper limb. results of 734 sympathicotomies. | thoracoscopic sympathicotomy (ts) evolved as treatment of choice in severe hyperhidrosis. the aim of this study was to assess the role of video-assistance in ts (vats) versus conventional ts (cts) for primary hyperhidrosis of the upper limb with regard to safety, side-effects and long-term outcome. | 2001 | 11695794 |
| a unique experience with human pre-immune (12 weeks) and hypo-immune (16 weeks) fetal thymus transplant in a vascular subcutaneous axillary fold in patients with advanced cancer: a report of two cases. | the successful development of fetal cell/tissue transplantation in adults has resulted in the possibility of eventual therapeutic solutions with a variety of intractable diseases. umbilical cord whole blood transplantation appears to be safe in the adult system. in severe forms of digeorge syndrome, cultured thymus transplant can help in the reconstitution of the immune condition of the host. successful fetal tissue transplant in adults has raised the hope of future effective gene transplant and ... | 2001 | 11695808 |
| the diagnostic value of bone scan in patients with renal cell carcinoma. | bone scan is performed as part of the evaluation of bone metastasis. we assessed the diagnostic value of bone scan in patients with renal cell carcinoma. | 2001 | 11696720 |
| thyroid hormone-induced oxidative damage on lipids, glutathione and dna in the mouse heart. | oxygen radicals of mitochondrial origin are involved in oxidative damage. in order to analyze the possible relationship between metabolic rate, oxidative stress and oxidative damage, of1 female mice were rendered hyper- and hypothyroid by chronic administration of 0.0012% l-thyroxine (t4) and 0.05% 6-n-propyl-2-thiouracil (ptu), respectively, in their drinking water for 5 weeks. hyperthyroidism significantly increased the sensitivity to lipid peroxidation in the heart, although the endogenous le ... | 2001 | 11697138 |
| thyroid function tests, serum lipids and gender interrelations in a middle-aged population. | to study the value of screening for thyroid function in a screening program for hyperlipidaemia. | 2001 | 11697562 |
| the role of the left temporal region under the cognitive motor demands of shooting in skilled marksmen. | a number of investigators have reported elevated left temporal alpha power in marksmen during response preparation. this finding has been interpreted to indicate the suppression of irrelevant cognitive processes. however, lower-order motor processes have not been excluded as a possible explanation. event-related alpha power (11-13 hz) was examined at sites t3, t4, c3, and c4 in eight skilled marksmen during shooting and two control tasks varying in perceptual-motor complexity. over an 8-s period ... | 2001 | 11698117 |
| mechanism underlying replication protein a stimulation of dna ligase i. | replication protein a (rpa) is a heterotrimeric single-stranded dna-binding protein that participates in multiple dna transactions that include replication and repair. base excision repair is a central dna repair pathway, responsible for the removal of damaged bases. we have shown previously that rpa was able to stimulate long patch base excision repair reconstituted in vitro. herein we show that human rpa stimulates the activity of the base excision repair component human dna ligase i by approx ... | 2002 | 11698410 |
| [acinic cell carcinomas of the parotid gland. a retrospective analysis]. | acinic cell carcinoma of the parotid gland is a rare malignant tumor, which is generally regarded as low grade. however, rapidly fatal courses do occur. | 2001 | 11699143 |
| abnormal eeg patterns in treatment-resistant schizophrenic patients. | this study was conducted in order to compare the eeg patterns of schizophrenics who do not respond to typical neuroleptics with those who do respond under typical neuroleptic medication and a group of controls. absolute (ap) and relative power (rp), and inter- and intrahemispheric correlations were calculated. nonresistant schizophrenics showed lower delta rp, higher alpha 1 ap and rp and higher correlation between prefrontal areas than the resistant ones and controls. resistant schizophrenics s ... | 2001 | 11699340 |
| extreme thyroid hormone resistance in a patient with a novel truncated tr mutant. | resistance to thyroid hormone (rth) is a syndrome in which patients have elevated thyroid hormone (th) levels and decreased sensitivity to its action. we describe a child with extreme rth and a severe phenotype. a 22-month-old female presented to the nih with goiter, growth retardation, short stature, and deafness. additionally, the patient had hypotonia, mental retardation, visual impairment, and a history of seizures. brain magnetic resonance imaging showed evidence of demyelination and bilate ... | 2001 | 11701667 |
| atrial natriuretic hormone, vessel dilator, long-acting natriuretic hormone, and kaliuretic hormone decrease the circulating concentrations of total and tree t4 and free t3 with reciprocal increase in tsh. | the present investigation was designed to determine whether atrial natriuretic peptides (anps) consisting of amino acids 1-30 [i.e. long-acting natriuretic hormone (lanh)], 31-67 (vessel dilator), 79-98 (kaliuretic hormone), and 99-126 (atrial natriuretic hormone [anh]) of the 126-amino acid anh prohormone decrease the circulating concentrations of total and free t4 and/or free t3 in healthy humans (n = 30). vessel dilator, kaliuretic hormone, lanh, and anh decreased the circulating concentratio ... | 2001 | 11701719 |
| patterns of abnormal fdg uptake by various histological types of non-small cell lung cancer at initial staging by pet. | the aim of this study was to identify useful patterns of abnormal fluorine-18 fluorodeoxyglucose (fdg) uptake by different types of non-small cell (nsc) lung cancer and to assess their clinical implications. one hundred and three sequential patients with newly diagnosed, pathology-proven nsc lung cancer were included. fdg positron emission tomography (pet) images were acquired using a dedicated pet scanner. there were 35 squamous cell carcinomas (sqc), 17 large cell cancers (lgc), 38 adenocarcin ... | 2001 | 11702114 |
| validation of a novel high-sensitivity radioimmunoassay procedure for measurement of total thyroxine concentration in psittacine birds and snakes. | to validate a novel high-sensitivity radioimmunoassay (ria) procedure developed to accurately measure the relatively low serum total thyroxine (t4) concentrations of birds and reptiles and to establish initial reference ranges fort4 concentration in selected species of psittacine birds and snakes. | 2001 | 11703019 |
| prognostic significance of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in voided urine samples from patients with transitional cell carcinoma of the bladder. | to study the role of urinary matrix metalloproteinase-1 (mmp-1) and tissue inhibitor of metalloproteinase-1 (timp-1) in bladder cancer and their relationship to tumor progression. | 2001 | 11705862 |
| [subclinical thyroid disease in institutionalised healthy geriatric population]. | our aim was to determine the prevalence of subclinical thyroid disease in a healthy institutionalised geriatric population. | 2001 | 11707219 |
| [significant role of cisplatin and 5-fu combination chemotherapy for first-line intensive treatment for advanced esophageal cancer]. | we evaluated the efficacy of first-line chemotherapy consisting of cisplatin and 5-fluorouracil combination therapy (in the following, fp) in intensive treatment for esophageal cancer. this first-line chemotherapy was administered to 18 patients with squamous cell carcinoma. three patients had t2 tumor, 10 had t3 and 5 had t4. lymph node metastasis was detected in 10 patients and not detected in 8 patients. five patients had distant metastasis. ten patients showed a partial response and the resp ... | 2001 | 11707991 |
| [efficacy of intraperitoneal chemotherapy for peritoneal recurrence of gastric carcinoma]. | we report a patient in whom intraperitoneal chemotherapy was effective against peritoneal recurrence of gastric carcinoma. a 74-year-old woman underwent total gastrectomy with splenectomy and transverse colectomy for borrmann type iv gastric carcinoma (curability b) in january 2000. the diagnosis was stage iv gastric carcinoma (t4, n2, p1, h0, m0 and cy0). in july 2000, peritoneal recurrence occurred along with slight elevation of cea. in september, two ports were inserted into the upper and low ... | 2001 | 11708002 |
| familial and sporadic forms of central core disease are associated with mutations in the c-terminal domain of the skeletal muscle ryanodine receptor. | central core disease (ccd) is an autosomal dominant congenital myopathy. diagnosis is based on the presence of cores in skeletal muscles. ccd has been linked to the gene encoding the ryanodine receptor (ryr1) and is considered to be an allelic disease of malignant hyperthermia susceptibility. however, the report of a recessive form of transmission together with a variable clinical presentation has raised the question of the genetic heterogeneity of the disease. analyzing a panel of 34 families e ... | 2001 | 11709545 |
| caveolin-1 expression is associated with high-grade bladder cancer. | to assess the levels of caveolin-1 in a series of bladder tumor specimens of varying stage and grade and to identify possible links between caveolin-1 status and clinical behavior. caveolae have emerged as sites of important regulatory events at the cell membrane in many different cell types. caveolins are the main structural components of caveolae and belong to a family of highly conserved integral membrane proteins. the function of caveolin-1 appears to be intrinsically linked to cell signalin ... | 2001 | 11711373 |
| pelvic wall involvement denotes a poor prognosis in t4 rectal cancer. | an aggressive surgical approach with en bloc resection of involved structures is often possible with anterior rectal cancers that invade adjacent visceral organs, but is rarely possible in tumors that invade the pelvic wall. however, most staging systems include both situations in the same group of t4 rectal cancers. we performed a retrospective study of patients with stage t4 rectal cancer undergoing surgery to assess the influence of different organ involvement on resectability and survival. | 2001 | 11711741 |
| identifying patients with t3-t4 node-negative colon cancer at high risk of recurrence. | adjuvant chemotherapy is effective for node-positive colon cancer patients. in node-negative patients, it could be justified in high-risk patients. the purpose of this study was to determine clinical and pathological findings associated with tumor recurrence in t3-t4 node-negative colon cancer patients. | 2001 | 11711742 |
| skin melanoma in saarland: incidence, survival and mortality 1970-1996. | over the past few decades, the incidence of cutaneous malignant melanoma has been rising in both sexes in almost all developed countries, notably those with fair-skinned populations. detailed population-based time trend analyses of skin melanoma incidence and survival in germany accounting for stage have not been published until now. we analysed skin melanoma data from the population-based saarland cancer registry in germany from 1970 to 1996. incidence rates were age-standardized. we estimated ... | 2001 | 11711755 |
| [results of radical cystectomy for management of invasive bladder cancer with special reference to prognostic factors and quality of life depending on the type of urinary diversion]. | bladder cancer is one of the main problems in urology in terms of diagnosis and treatment, due to its high incidence, high recurrence rate, and difficulties in prognosis of its natural history. according to polish epidemiological reports, bladder cancer was the fifth cause of death due to malignant diseases in 1993 (1.2% in females and 4.0% in males). radical cystectomy remained for over forty years the main method of treatment in cases of invasive bladder cancer. improvements in postoperative c ... | 2000 | 11712306 |
| [anterior chest wall reconstruction with myocutaneous flap after open drainage for infectious bulla and empyema following t4 lung cancer resection via anterior approach]. | a 48-year-old man with t4 lung cancer underwent resection of the right upper lobe, chest wall, and superior vena cava, and reconstruction of the last 2 tissues via anterior approach after induction chemo-radiotherapy. however, a bulla in the apical segment of the lower lobe divided by stapling was infected after the operation, and open drainage through the anterior chest wall was mandatory due to massive air leak and spread of infection to the pleural space. as the incision were fortunately rest ... | 2001 | 11712368 |
| [two cases of multi-drug-resistant pulmonary tuberculosis with para-aminosalicylic acid (pas)-induced hypothyroidism]. | two cases of multi-drug-resistant pulmonary tuberculosis with para-aminosalicylic acid (pas)-induced hypothyroidism were reported. case 1; a 73-year-old male, complaining of edema, was admitted to our hospital. he had been treated for his multi-drug-resistant pulmonary tuberculosis during the past 1 year with an antituberculous regimen consisting of ethambutol (eb), ethionamide (eth) and pas. a thyroid profile performed when he was admitted to our hospital showed several marked abnormalities: se ... | 2001 | 11712388 |
| loss of heterozygosity and its correlation with clinical outcome and epstein-barr virus infection in nasopharyngeal carcinoma. | sixty-one human nasopharyngeal carcinomas (npc) were examined by allelotype analysis for the purposes of detecting potential association between loss of heterozygosity (loh), clinicopathological parameters and epstein-barr virus (ebv) infection. loh was performed using 257 polymorphic markers on 22 chromosomes. high frequency loh (> or = 60%) was observed on 12 chromosome arms including 1p, 2p, 2q, 3p, 3q, 5q, 9p. 9q, 11q, 13q, 14q and 17q, with the highest loh frequency of 91% on 3p. seventy-th ... | 2001 | 11712805 |
| radiotherapy alone for clinical t4 skin carcinoma of the head and neck with surgery reserved for salvage. | to evaluate the outcomes of definitive radiotherapy in the treatment of clinical stage t4 cutaneous carcinomas of the head and neck. | 2001 | 11713722 |
| cancer of the buccal mucosa: are margins and t-stage accurate predictors of local control? | cancer of the buccal mucosa is an uncommon and aggressive neoplasm of the oral cavity. less than 2% of patients treated for cancer of the oral cavity at roswell park cancer institute (rpci) from 1971 to 1997 had primary buccal cancers. because the majority of these patients did not undergo any adjuvant treatment, this group provided us with the opportunity to assess the relationship between margin status and local recurrence for both small (t1-t2) and large (t3-t4) tumors treated with surgery al ... | 2001 | 11713724 |
| phytoextraction of cd and pb and physiological effects in potato plants (solanum tuberosum var. spunta): importance of root temperature. | three consecutive years of field experiments were carried out to investigate the effect of different root-zone temperatures, induced by the application of mulches, on the concentration and accumulation of cd and pb and on bioindicators (chlorophylls, catalase, peroxidase and cell wall fractions) in different organs of potato plants (roots, tubers, stems, and leaflets). four different plastic covers were employed (t1, transparent polyethylene; t2, white polyethylene; t3, white and black coextrude ... | 2001 | 11714328 |
| epidermoid cyst of the thoracic spine: case history. | epidermoid cysts of the spinal cord are very rare tumors. we report a 31 year-old female who presented with a 5 months history of progressive lower extremity weakness and spasticity. magnetic resonance imaging of the thoracic spine revealed a 2 cm intradural, extramedullary mass at the t4-5 level. a t4 and t5 osteoplastic laminotomy with complete removal of the intradural mass was performed. intraoperative and final histological examination revealed an epidermoid cyst. epidermoid cysts must be a ... | 2001 | 11714565 |
| [target volume in radiotherapy of gastric adenocarcinoma]. | the spread of gastric adenocarcinoma may follow three main patterns: hematogenic, lymphatic and intraperitoneal. a gtv should be considered in preoperative or exclusive radiation therapy. after non-radical surgery, a "residual gtv" will be defined with the help of the surgeon. the ctv encompasses three intricated volumes. a) a "tumor bed" volume. after radical surgery, local recurrences appear as frequent as distant metastases. the risk depends upon the depth of parietal invasion and the nodal s ... | 2001 | 11715304 |
| type 2 iodothyronine deiodinase expression is upregulated by the protein kinase a-dependent pathway and is downregulated by the protein kinase c-dependent pathway in cultured human thyroid cells. | type 1 and 2 iodothyronine deiodinases (d1 and d2) catalyze thyroxine (t4) activation. in human thyroid, unlike rodents', both d1 and d2 are expressed. we have investigated the effects of thyrotropin (tsh), dibutyryl cyclic adenosine monophosphate [(bu)2camp] (an activator of protein kinase a [pka]), 12-o-tetradecanoylphorbor 13-actate (tpa) (an activator of protein kinase c [pkc]), t4, and triiodothyronine (t3) on the d2 mrna levels and activity in cultured human thyroid cells. d2 mrna levels w ... | 2001 | 11716036 |
| effect of 131 iodine therapy on the course of graves' ophthalmopathy: a quantitative analysis of extraocular muscle volumes using orbital magnetic resonance imaging. | there remains uncertainty as to the effect of radioactive iodine (131i) therapy on the associated ophthalmopathy (go). twenty newly diagnosed patients with graves' hyperthyroidism treated with 131i (median dose, 15.5 mci) were followed with ophthalmologic evaluations (oe) and magnetic resonance imaging (mri) at baseline, 2, and 6 months, and with oe alone at 3 years. for mri, the superior, inferior, and medial rectus muscle volumes and total muscle volumes (tmv) were measured. replacement levoth ... | 2001 | 11716044 |
| the acute effect of calcium carbonate on the intestinal absorption of levothyroxine. | to determine the acute effect of calcium, we measured levothyroxine absorption after ingestion of thyroxine (t4) with and without simultaneous ingestion of calcium (as calcium carbonate) in seven volunteers without thyroid disease. serum total t4, total triiodothyronine (t3), free t4, and thyrotropin (tsh) levels were measured after ingestion of 1,000 microg of levothyroxine on two separate visits at 4-week intervals: (1) levothyroxine alone and (2) levothyroxine together with 2.0 g of calcium a ... | 2001 | 11716045 |
| aggressive metastatic follicular thyroid carcinoma with anaplastic transformation arising from a long-standing goiter in a patient with pendred's syndrome. | in this article we describe detailed pathological and molecular genetics studies in a consanguineous kindred with pendred's syndrome. the index patient was a 53-year-old female patient with congenital deafness and goiter. her parents were first-degree cousins. she had a large goiter (150 g) that had been present since childhood. one of her sisters and a niece are also deaf and have goiter as well. the presence of pendred's syndrome was confirmed by a positive perchlorate test and the demonstrati ... | 2001 | 11716048 |
| [evaluation of magnetic resonance imaging in staging of laryngeal cancer]. | to evaluate the value of the preoperative t staging of laryngeal cancer by mri. | 1998 | 11717894 |
| [the extended indications of near-total laryngectomy]. | to evaluate near-total laryngectomy in treatment of laryngeal cancers. | 1998 | 11717912 |
| [a preliminary result of treatment of progressive multiple sclerosis with autologous peripheral blood stem cell transplantation in china]. | to explore the clinical effect for treatment of progressive multiple sclerosis (pms) by autologous peripheral blood stem cell transplantation (auto-pbsct). | 2001 | 11718058 |
| blood pressure and heart rate response to isometric exercise: the effect of spinal cord injury in humans. | the systolic (sp) and diastolic (dp) blood pressure and heart rate (hr) responses during a fatiguing isometric contraction of either the handgrip or quadriceps muscles was measured in 139 paraplegic patients divided into five groups (having injuries at t4, t12 and l1-l3 and suffering complete paraplegia and having injuries at t4 but showing incomplete hemiplegia or paraplegia) and 25 controls. while all handgrip exercise was maintained by voluntary effort, only the controls were able to make a v ... | 2001 | 11718279 |
| local therapy for rectal cancer. | in selected patients with early rectal cancer, local therapy is an effective alternative to radical resection and offers minimal morbidity and the avoidance of a colostomy. several techniques are described: transanal excision, dorsal approaches (york-mason or kraske procedures), transanal endoscopic microsurgery, endocavitary radiation, and transanal fulguration. among these, transanal excision is favored for the low rate of complications, promising outcomes, and ability to secure tissue for pat ... | 2001 | 11719030 |
| plasma thyroid hormones and growth hormone in embryonic and growing emus (dromaius novaehollandiae). | growth hormone (gh), thyroxine (t4) and tri-iodothyronine (t3) are known to be involved in the regulation of growth and development in a variety of avian species. it has been suggested that an absence of gh and thyroid hormones in ostriches is the cause of their neoteny, a phenomenon in which juvenile characteristics are retained into adulthood. neoteny is typical of all ratites, the single group of flightless birds that includes the ostrich, but similar endocrine studies have not been performed ... | 2001 | 11720129 |
| p15(ink4b) in bladder carcinomas: decreased expression in superficial tumours. | the p15 gene which encodes a cyclin-dependent kinase inhibitor, is located in the 9p21 chromosomal region that is frequently deleted in human bladder transitional cell carcinomas (tccs). the aim of the present paper is to study the potential involvement of the p15 gene in the evolution of tccs. p15 mrna expression was investigated by semi-quantitative rt-pcr in a series of 75 tccs, 13 bladder cell lines and 6 normal bladder urothelia by semi-quantitative rt-pcr. p15 was expressed in the normal u ... | 2001 | 11720438 |
| results of resting and ambulatory electrocardiograms in patients with hypothyroidism and after return to euthyroid status. | hypothyroidism is not infrequently associated with an abnormally long qtc interval (> or = 450 msec). rarely, marked prolongation of the qtc interval and malignant ventricular arrhythmias have been reported. in this study, qtc intervals on resting electrocardiograms (ecgs) were compared in 10 patients before and after treatment of hypothyroidism. the qtc interval increased in seven patients during euthyroidism compared with hypothyroidism, and decreased in three patients. during hypothyroidism, ... | 1999 | 11720599 |
| surgical treatment of stage iii non-small cell lung cancer. | the resectability of nsclc is determined by its stage. the surgical treatment in stage i and ii nsclc remains a golden standard. stage iiia nsclc constitutes a non-homogenous group, and many patients are potentially non-resectable. the patients in stage iiia nsclc also constitute a non-homogenous group. the patients in stage t3n1 usually undergo surgical resection, but many patients with n2 disease are disqualified from surgical treatment due to the negative prognostic factors. the negative prog ... | 2001 | 11720755 |
| binding of nucleotides by t4 dna ligase and t4 rna ligase: optical absorbance and fluorescence studies. | the interaction of nucleotides with t4 dna and rna ligases has been characterized using ultraviolet visible (uv-vis) absorbance and fluorescence spectroscopy. both enzymes bind nucleotides with the k(d) between 0.1 and 20 microm. nucleotide binding results in a decrease of absorbance at 260 nm due to pi-stacking with an aromatic residue, possibly phenylalanine, and causes red-shifting of the absorbance maximum due to hydrogen bonding with the exocyclic amino group. t4 dna ligase is shown to have ... | 2001 | 11721015 |
| [thyroid hormones, obesity and brown adipose tissue thermogenesis]. | brown adipose tissue (bat) is the main site for hormone-dependent (non-shivering) thermogenesis in response to cold in lower mammals. the hypothalamus controls the cold-induced bat activation by stimulating the sympathetic nerves and the secretion of norepinephrine (ne) in bat. mediated by beta-3 noradrenergic receptor and in the presence of triiodothyronine (t3), ne promotes the synthesis of the uncoupling protein 1 (ucp1). ucp1 is a 32 kda protein located in the inner membrane of bat mitochond ... | 2001 | 11721329 |
| influence of feeding level during postweaning growth on circulating concentrations of thyroid hormones and extrathyroidal 5'-deiodination in steers. | an experiment was conducted with 42 growing montbéliard steers to study the effect of feed restriction, followed by refeeding, on circulating concentrations of thyroxine (t4) and triiodothyronine (t3) and on hepatic and muscle activities of 5'-deiodinase (5'd). at 9 mo of age, 21 steers were diet-restricted for 3 mo (adg, 641 g/d), prior to a 4-mo compensatory growth period with ad libitum access to the same diet (adg, 1,240 g/d). they were compared to 21 control steers continuously gaining 1,10 ... | 2001 | 11721848 |
| combined video-assisted mediastinoscopy and video-assisted thoracoscopy in the management of lung cancer. | this study seeks to assess the safety and usefulness of combined video-assisted mediastinoscopy and video-assisted thoracoscopy in the management of patients with lung cancer. | 2001 | 11722067 |
| thyroid function test abnormalities in newly admitted psychiatric patients residing in an iodine-deficient area: patterns and clinical significance. | the prevalence of abnormal in-vitro thyroid function tests in psychiatric in-patients may be as high as 24%. thus far, however, there is only limited data addressing the underlying causes of these abnormal test results, i.e. how often they can be attributed to genuine thyroid disease. | 2001 | 11722306 |
| effect of mivacurium 200 and 250 &mgr;g/kg in infants during isoflurane anesthesia: a randomized controlled trial [isrctn07742712]. | background: infants usually respond differently to a neuromuscular relaxant compared to children or adults. isoflurane is commonly used as an anesthetic gas in infants. in an rct design, we investigated whether a dose of mivacurium 250 &mgr;g/kg results in faster onset of action than 200 &mgr;g/kg in infants under isoflurane anesthesia. spontaneous recovery times and cardiovascular response were also evaluated. methods: twenty-four low surgical risk children, aged 6-24 months, undergoing an elec ... | 2001 | 11722796 |
| comparison of dna damage photoinduced by ketoprofen, fenofibric acid and benzophenone via electron and energy transfer. | ketoprofen (kp) and fenofibrate, respectively, anti-inflammatory and hypolipidemiant agents, promote anormal photosensitivity in patients and may induce photoallergic cross-reactions correlated to their benzophenone-like structure. here, their ability to photosensitize the degradation of biological targets was particularly investigated in dna. the photosensitization of dna damage by kp and fenofibric acid (fb), the main metabolite of fenofibrate, and their parent compound, benzophenone (bz), was ... | 2001 | 11723794 |
| outcomes of radiotherapy for inoperable locally advanced (t4) esophageal cancer-retrospective analysis-. | to assess the treatment outcome after radiotherapy with or without chemotherapy for inoperable locally advanced (t4) esophageal cancer (ec), a retrospective analysis was performed. we enrolled 37 patients with t4 ec and analyzed 35 patients. a total of 28 patients were treated with radiotherapy and chemotherapy (median dose, 60 gy) and seven patients were treated with radiation alone (median dose, 60 gy). many mainly received high-dose cisplatin (cddp) and 5-fluorouracil (fu) or continuous infus ... | 2001 | 11724253 |
| [treatment of euthyroid goiter in the elderly]. | a study was conducted to evaluate the effectiveness of the medical therapy with synthetic hormone levothyroxine (l-t4) in the elderly subjects with multinodular euthyroid goiter. | 2001 | 11725614 |
| huge response to letrozole in inoperable t4 breast cancer: a case report. | a 73 years-old woman presented with locally advanced breast cancer (ct4b cn1 m0, stage iiib) and atrial flutter. because of the arrhythmia, chemotherapy or tamoxifen, although malignancy was hormone-sensitive, were discarded. letrozole was started. two months later, the breast nodule and skin ulceration cleared up. surgery was performed. nowadays, 24 months later, patient does fine, continuing letrozole as adjuvant treatment. | 2001 | 11725620 |
| nasopharyngeal carcinomas: analysis of patient, tumor and treatment characteristics determining outcome. | the present study reviews the experience in treatment of 447 patients with nasopharyngeal carcinomas, analyzing patient, tumor and treatment characteristics determining outcome. | 2001 | 11730993 |
| ablation of tralpha2 and a concomitant overexpression of alpha1 yields a mixed hypo- and hyperthyroid phenotype in mice. | thyroid hormone governs a diverse repertoire of physiological functions through receptors encoded in the receptor genes alpha and beta, which each generate variant proteins. in mammals, the alpha gene generates, in addition to the normal receptor tralpha1, a non-hormone-binding variant tralpha2 whose exact function is unclear. here, we present the phenotype associated with the targeted ablation of tralpha2 expression. selective ablation of tralpha2 resulted in an inevitable, concomitant overexpr ... | 2001 | 11731613 |
| thyroid hormone-responsive pituitary hyperplasia independent of somatostatin receptor 2. | mice homozygous for the targeted disruption of the glycoprotein hormone alpha-subunit (alphagsu) display hypertrophy and hyperplasia of the anterior pituitary thyrotropes. thyrotrope hyperplasia results in tumors in aged alphagsu(-/-) mice. these adenomatous pituitaries can grow independently as intrascapular transplants in hypothyroid mice, suggesting that they have progressed beyond simple hyperplasia. we used magnetic resonance imaging to follow the growth and regression of thyrotrope adenoma ... | 2001 | 11731614 |