| detection of antihepatitis c virus antibody in severe epstein-barr virus-induced hepatitis. | | 1991 | 1649223 |
| [an adult case of virus-associated hemophagocytic syndrome (vhas) and a review of this syndrome in adults in japan]. | an adult case of virus-associated hemophagocytic syndrome (vahs) was reported and a review of this syndrome in adults in japan was also made. a 79 year-old woman was referred to our hospital for detailed examination for sustained generalized fatigue lasting for about two weeks. other clinical manifestations of this patient included fever, generalized lymphadenopathy, hepatosplenomegaly, anemia and mild liver dysfunction. the biopsy of the lymph node revealed hyperplasia of histiocyte with hemoph ... | 1991 | 1649234 |
| [an autopsied case of chronic active epstein-barr virus (ebv) infection with various symptom]. | a 19-year-old boy, who complained of fever and fatigue was hospitalized in november 1986. on physical examination, he had a temperature of 37 degrees c, cervical lymphadenopathy and hepatosplenomegaly. serum transaminase was elevated moderately, while serum alkaline-phosphatase was elevated severely. extremely elevated antibody titers to the ebv capsid antigen (igg: 2560x, iga: 160x), early antigen (igg: 1280x, iga: 160x) and nuclear antigen (160x) were noted. ppd and dncb skin test were negativ ... | 1991 | 1649235 |
| zebra and a fos-gcn4 chimeric protein differ in their dna-binding specificities for sites in the epstein-barr virus bzlf1 promoter. | epstein-barr virus (ebv) encodes a protein, zebra, which enables the virus to switch from a latent to a lytic life cycle. the basic domain of zebra is homologous to the fos/jun oncogene family, and both proteins bind the canonical ap-1 site (tgagtca). however, zebra does not contain a leucine zipper dimerization domain which has been shown to be necessary for dna binding of fos/jun proteins. additionally, zebra binds to sites which deviate from the ap-1 consensus sequence. thus, it was of intere ... | 1991 | 1649314 |
| epstein-barr virus nuclear protein 2 transactivates a cis-acting cd23 dna element. | epstein-barr virus (ebv) nuclear protein 2 (ebna-2) is essential for b-lymphocyte growth transformation. ebna-2 upregulates mrnas encoding cd23, a b-lymphocyte surface protein closely associated with ebv-induced growth transformation. to further investigate this ebna-2 effect, we searched in the genomic dna spanning the type a and type b cd23 mrna start sites for a cis-acting fragment that would render a promoter transactivatable by ebna-2. an 800-bp cd23 dna fragment (-335 to +465 relative to t ... | 1991 | 1649318 |
| characterization of a new human multiple myeloma cell line, umjf-2, which suppresses antibody production by b-lymphocytes in vitro. | a new human plasma cell line, umjf-2, has been derived from the bone marrow of a patient with multiple myeloma. morphological studies disclosed large nucleoli, moderate numbers of mitochondria, and scant endoplasmic reticulum consistent with a plasmablastic morphology. the cells have immunologic characteristics of early plasma cells, including intense expression of cytoplasmic igg-lambda and weaker, but discernible, expression of surface igg-lambda. cell surface antigens defined by the monoclona ... | 1991 | 1649357 |
| acute primary epstein-barr virus infection presenting as acute abdomen. | | 1991 | 1649432 |
| polymerase chain reaction (pcr) for detection of bamhi polymorphism at the thrb gene. | | 1991 | 1649459 |
| polymerase chain reaction (pcr) for detection of ecori polymorphism at the thrb gene. | | 1991 | 1649460 |
| pcr detection of the hindiii polymorphism at the thyroid hormone receptor, beta, gene (thrb). | | 1991 | 1649461 |
| occurrence of lymphoproliferative disorders in heart transplant recipients. | lymphoproliferative diseases may occur as a complication of severe immunosuppression. in our own center two out of 46 heart transplant recipients, receiving a cyclosporin a containing immunosuppressive regimen, presented with this complication and are reported here. hepatic involvement and an occult small bowel localisation, which only became evident after a chemotherapy-induced small bowel perforation, illustrate the predilection of posttransplant lymphoproliferations for extranodal sites. both ... | 1991 | 1649531 |
| expression, structure, and function of the cd23 antigen. | | 1991 | 1649548 |
| subcellular distribution and life cycle of epstein-barr virus in keratinocytes of oral hairy leukoplakia. | the authors investigated the life cycle of epstein-barr virus (ebv) in keratinocytes of oral hairy leukoplakia by combining immunohistochemistry. dna in situ hybridization, and lectin histochemistry with electron microscopy. diffuse-staining components of the ebv early antigen complex (ea-d), ebv 150-kd capsid antigen (vca), ebv membrane antigen (gp350/220), and double-stranded dna were labeled with monoclonal antibodies. an ebv-dna probe was used to locate ebv dna. wheat-germ agglutinin (wga) w ... | 1991 | 1649554 |
| epstein-barr viral genome in lymph nodes from patients with hodgkin's disease may not be specific to reed-sternberg cells. | a possible etiologic role for epstein-barr virus (ebv) in hodgkin's disease (hd) was investigated by probing for ebv genome in 52 biopsy specimens involved with hd and 43 hyperplastic lymph node specimens. using dot-blot hybridization (bam hiw probe), southern blot hybridization (xho i probe), and polymerase chain reaction analyses, 27%, 27%, and 58% of the nodes with hd were positive for ebv genome, respectively, as compared to 16%, 14%, and 43% in the hyperplastic lymph nodes. clonal and noncl ... | 1991 | 1649556 |
| proteolytic fragmentation of tetanus toxin by subcellular fractions of jy, a b lymphoblastoid cell line. | proteolysis of 125i-labelled tetanus toxin by subcellular fractions from an epstein-barr-virus-transformed b lymphoblastoid cell line, jy, was investigated. fractions enriched in lysosomes and plasma membranes cleaved the toxin molecule at several sites, with a ph optimum of 5.5. n-terminal sequence analysis of mr-81,000, -45,000 and -35,000 proteolytic fragments indicated cleavage of the asp-460-leu-461, asp-872-glu-873 and ile-1013-thr-1014 peptide bonds, all sites located within the heavy cha ... | 1991 | 1649603 |
| measurement of urokinase-type plasminogen activator activity in sera of nasopharyngeal carcinoma patients by an immunocapture assay. | the urokinase-type plasminogen activator (upa) activity in sera of patients suffering from nasopharyngeal carcinoma was examined by a upa-specific immunocapture assay. the results revealed that the activity levels in the patient sera were significantly higher than that of normal healthy controls. the upa activity also increased with the staging of the disease and the anti-ebv vca iga titre which is a diagnostic test for the disease, although the results were not statistically different. these fi ... | 1991 | 1649695 |
| epstein-barr virus activators, mutagens and volatile nitrosamines in preserved food samples from high-risk areas for nasopharyngeal carcinoma. | representative samples of preserved foods collected from high-risk areas for nasopharyngeal carcinoma were assayed for capacity to induce epstein-barr virus (ebv) by measuring induction of the dr promoter gene or of genes for early antigens in raji cells. the two assays gave concordant results, but the dr induction assay detected ebv-inducing substances at lower concentrations and more reproducibly. three of 17 preserved food items were active in both assays; they were also weakly mutagenic in t ... | 1991 | 1649791 |
| chemical transformation of human embryonic nasopharyngeal epithelial cells in vitro. | the association of epstein-barr virus (ebv) with poorly differentiated carcinoma of the nasopharynx is well known; however, certain environmental factors, such as nitrosamines, are also important for the development of this cancer (ho, 1975). n,n'-dinitrosopiperazine (dnpz) can induce nasopharyngeal carcinoma in rats and increased sister chromatid exchange frequency in human embryonic nasopharyngeal epithelial (hene) cells. we have now demonstrated the transformation by dnpz of hene cells, which ... | 1991 | 1649792 |
| different pathways of uptake and degradation of sphingomyelin by lymphoblastoid cells and the potential participation of the neutral sphingomyelinase. | the metabolism of sphingomyelin (spm) was investigated in epstein-barr virus-transformed lymphoid cell lines from normal individuals and from patients with niemann-pick disease type a (deficient in the acid, lysosomal sphingomyelinase) and familial hypercholesterolemia (lacking the low density lipoprotein receptor). cells were incubated with the following radioactive or fluorescent spms: [choline-methyl-14c] spm, [oleoyl-3h]spm, pyrene-propenoyl-spm (p3:1-spm), pyrene-butanoyl-spm (p4-spm), pyre ... | 1991 | 1649823 |
| lymphoepithelioma-like carcinoma of the skin with adnexal differentiation. | lymphoepithelioma-like carcinoma of the skin (lelcs) is a recently-described tumor entity with a microscopic resemblance to undifferentiated carcinoma of the nasopharynx. only five cases of this lesion have been reported heretofore. we document three additional examples of lelcs that were composed of clustered dermal arrays of cytologically malignant, mitotically active polygonal cells, without connections to the overlying epidermis or skin appendages. chronic inflammatory cells were intersperse ... | 1991 | 1649848 |
| a deletion map of the human immunoglobulin heavy chain variable region. | analysis of vh gene segments deleted in the process of immunoglobulin heavy chain (igh) variable region assembly in three series of monoclonal b cell lines has been used to determine the human vh region organization. a deletion map of the relative positions of 21 different vh gene segments has been determined. the characterization of b cell lines from three unrelated adults of two racial groups yielded the same relative vh gene segment order, suggesting that the overall order of vh genes in the ... | 1991 | 1649888 |
| the epstein-barr virus carrier state: dominance of a single growth-transforming isolate in the blood and in the oropharynx of healthy virus carriers. | epstein-barr virus (ebv) isolates can be broadly classified as type 1 or type 2 on the basis of allelic polymorphism of the virus-encoded nuclear antigens ebnas 2, 3a, 3b and 3c, and individually identified based on mr values of their ebna proteins (ebna type). here we have used this natural heterogeneity amongst isolates to re-examine the question of ebv persistence in vivo, asking in particular whether virus carriage in oropharyngeal epithelium and/or in b lymphoid tissues involves infection w ... | 1991 | 1649896 |
| host cell phenotype-dependent methylation patterns of epstein-barr virus dna. | we have shown previously that the ebna 1 and latent membrane protein encoding regions of the epstein-barr virus (ebv) genome are highly methylated at ccgg sequences in the burkitt's lymphoma (bl)-derived cell line rael, but are unmethylated in a lymphoblastoid cell line (lcl) harbouring the same virus. to examine whether this is a regular phenomenon, we compared the methylation patterns of selected regions (bamhi c, w, h, m, e, k and n fragments) of ebv dna in representative ebv-carrying cell ty ... | 1991 | 1649897 |
| chronic fatigue syndrome. new disease on the horizon. | | 1991 | 1649915 |
| establishment of a new epstein-barr virus nuclear antigen-positive b-cell line, ball-2, with t(8;14) (q24;q32) chromosome abnormality from b-cell acute lymphoblastic leukemia, l2. | a new epstein-barr virus nuclear antigen (ebna)-positive b-cell line, designated ball-2, was spontaneously established from the peripheral blood of a 14-year-old boy with an ebna-negative b-cell acute lymphoblastic leukemia (b-all), l2 in the french-american-british classification. the ball-2 cell line grew in suspension with or without forming clumps of cells. the cultured cells exhibited lymphoid morphology with indented or lobulated nuclei, prominent nucleoli, and relatively abundant cytoplas ... | 1991 | 1650133 |
| illegitimate (or ectopic) transcription proceeds through the usual promoters. | illegitimate transcription corresponds to the low level presence of specific transcripts in nonspecific cells. this phenomenon allows to analyse any tissue-specific disease transcript in any easily accessible cell. we demonstrate here that the start sites of transcription are the same in specific and non-specific cells, which indicates that illegitimate transcription is due to a low level activity of the normal promoter. in addition, it is possible to increase about 10 fold the abundance of ille ... | 1991 | 1650193 |
| frequent detection of epstein-barr virus dna by the polymerase chain reaction in lymph node biopsies from patients with hodgkin's disease without genomic evidence of b- or t-cell clonality. | this study of 52 swiss patients with hodgkin's disease (hd), including 17 cases with a high content of sternberg-reed (sr) and hodgkin (h) cells, was performed to determine the percentage of cases harboring epstein-barr virus (ebv) dna and/or clonal rearrangements of ig and t-cell antigen receptor (tcr) genes in diagnostic lymph node biopsies. special attention was drawn to the heavily infiltrated cases to detect a possible relationship between clonality and ebv dna identification. ebv dna was d ... | 1991 | 1650264 |
| epstein-barr virus and persistent graft dysfunction after liver transplantation. | epstein-barr virus infection has been associated with a broad spectrum of clinical manifestations, depending on the immune status of the host. in this report, we describe two liver transplant patients who received hepatic allografts from donors serologically positive for epstein-barr virus and who experienced primary infection with epstein-barr virus associated with prolonged liver graft dysfunction. in both patients, epstein-barr serologies converted within 3 mo of liver transplantation, and he ... | 1991 | 1650326 |
| immunological characterization of the epstein-barr virus phosphoprotein pp58 and deoxyribonuclease expressed in the baculovirus expression system. | the open reading frames of the phosphoprotein pp58 (bmrfi) and the deoxyribonuclease (bglf5) of the epstein-barr-virus (ebv) strain m-aba were cloned in the baculovirus expression vectors pac373 and pac360 and expressed in the spodoptera frugiperda (sf158) insect cells. the recombinant phosphoprotein pp58 expressed in sf158 cells was recognized by the anti-pp58 rabbit anti-sera which were generated by immunizing rabbits with a trpe-bmrfi fusion protein expressed in e. coli. dna-cellulose chromat ... | 1991 | 1650330 |
| recurrent upper respiratory infection, persistent paravertebral thoracolumbar muscle spasm, and fatigue associated with chronic active epstein-barr virus infection. | | 1991 | 1650418 |
| lymphoepithelioma-like carcinoma and its relationship to epstein-barr virus. | | 1991 | 1650531 |
| fulminant childhood hemophagocytic syndrome mimicking histiocytic medullary reticulosis. an atypical form of epstein-barr virus infection. | ten cases of pediatric fulminant hemophagocytic syndrome, encountered between 1986 and 1989, are described. they occurred in the summer, and the patients presented with fever, jaundice, hepatosplenomegaly, pancytopenia, coagulopathy, and abnormal liver function. bone marrow studies revealed infiltration by atypical t-lymphoid cells, rare b immunoblasts, and mature histiocytes with hemophagocytosis. initially, histiocytic medullary reticulosis was suspected in six cases. the clinical course was c ... | 1991 | 1650532 |
| poorly differentiated adenocarcinoma with lymphoid stroma (lymphoepithelioma-like carcinomas) of the stomach. report of three cases with epstein-barr virus genome demonstrated by the polymerase chain reaction. | lymphoepithelioma of the nasopharynx is an undifferentiated carcinoma with prominent lymphoid infiltration. histologically similar tumors have been documented in the skin, lung, thymus, salivary gland, tonsil, and uterine cervix. the authors report three cases of gastric carcinoma that were histologically and immunohistochemically similar to lymphoepithelioma. the patients were elderly white persons (61, 76, and 77 years of age); two of them had previous partial gastric resections for benign ulc ... | 1991 | 1650533 |
| viruses and cancer. | the fact that viruses can cause cancer in animals has been appreciated since the turn of the century. the widely held belief that viruses had little to do with cancer in humans has only recently been dispelled. two classes of human retrovirus (htlv and hiv) have been discovered in the last decade and the malignant potential of hepatitis b virus, epstein barr virus and the human papilloma virus have been documented not only by confirming their association with disease by large scale epidemologica ... | 1991 | 1650623 |
| sequential serological studies of homosexual men with and without hiv infection. epstein-barr virus activation preceding and following hiv seroconversion. | viral cofactors may be important in the pathogenesis of hiv infection and the development of aids, but their role is still imperfectly understood. sequential serological studies were performed in a cohort of 100 homosexual men and 70 matched healthy controls over a mean period of 4 years. of the patients, 18 were found to be hiv+ on admission to the study and 15 seroconverted to hiv+ during the follow up (seroconversion group). serum antibodies of both igg and iga isotypes against epstein-barr v ... | 1991 | 1650655 |
| epstein-barr virus in oropharyngeal and nasopharyngeal secretions of patients with nasopharyngeal carcinoma and control subjects. | the frequency of oropharyngeal excreters of the epstein-barr virus among patients with nasopharyngeal carcinoma in hong kong was compared with those of healthy adults in hong kong and california. 6 (3%) of 177 patients, 11 (12%) of 92 hong kong residents, and 20 (15%) of 132 californians were excreters. the virus was detected in the nasopharyngeal secretion of only 1 of 67 patients and in 2 of 73 healthy adults. no convincing evidence for neutralizing antibody in the throat wash and nasopharynge ... | 1991 | 1650762 |
| reactivation of epstein-barr virus during early infection with human immunodeficiency virus. | reactivation of epstein-barr virus (ebv) in early human immunodeficiency virus (hiv) infection was investigated in 49 homosexual men who seroconverted to hiv (cases) as compared with 49 matched controls who remained seronegative to hiv during a longitudinal study. ebv infection was reactivated in cases 6 months, but not 12 months, prior to hiv seroconversion as compared with controls and remained reactivated during 18 months of follow-up after hiv seroconversion, as shown by increases in immunog ... | 1991 | 1650790 |
| simplified procedures for applying the polymerase chain reaction to routinely fixed paraffin wax sections. | the polymerase chain reaction was applied to the analysis of dna contained in archival paraffin wax embedded material. dna suitable for the reaction was obtained from these tissues by simple extraction methods, without previous dewaxing of tissue sections. when compared with unfixed material, the reaction efficiency was compromised, so that an increased number of amplification cycles were required to produce equivalent amounts of amplified product. this in turn led to an increase in amplificatio ... | 1991 | 1650795 |
| a case of new daily persistent headache with elevated antibodies to epstein-barr virus. | a 45-year-old woman presented with persistent headache which was of acute onset and occurred daily. laboratory findings included thrombocytosis, elevated levels of antinuclear antibody, rheumatoid factor, and antibodies to epstein-barr virus (ebv). magnetic resonance image of the head, left selective external carotid angiography, temporal arterial biopsy, and cerebrospinal fluid revealed no abnormal findings that could explain her headache. her headache was compatible with ndph, which has been r ... | 1991 | 1650858 |
| [hairy leukoplakia: current concepts]. | current data about oral hairy leukoplakia are reported. clinical manifestations, histological and ultrastructural features and pathogenic mechanisms are firstly described. then diagnosis are exposed. finally, management is discussed. | 1991 | 1651048 |
| epstein-barr virus transformation of cryopreserved lymphocytes: prolonged experience with technique. | | 1991 | 1651051 |
| analysis of local antibody production in the vitreous humor of patients with severe uveitis. | we analyzed the local antibody production in vitreous humor samples collected during vitrectomy in patients with severe vision-threatening uveitis. in 24 patients, paired serum and undiluted vitreous humor samples were collected and tested for antibodies against toxoplasma gondii, herpes simplex virus, varicella-zoster virus, cytomegalovirus, epstein-barr virus, and toxocara canis. total igg and the goldmann-witmer coefficient were determined. the initial diagnosis of ocular toxoplasmosis could ... | 1991 | 1651055 |
| detection of epstein-barr virus sequences in hodgkin's disease by the polymerase chain reaction. | the authors examined paraffin-embedded lymph node biopsies from 65 cases of hodgkin's disease for the presence of epstein-barr virus (ebv) dna, using the highly sensitive polymerase chain reaction technique. overall 40% of the cases were positive for ebv dna; there were no statistically significant differences in the frequency of ebv positivity among the different subtypes of hodgkin's disease. these results are in agreement with those of previous studies that employed less sensitive detection t ... | 1991 | 1651058 |
| undifferentiated carcinoma of the salivary gland in greenlandic eskimos: demonstration of epstein-barr virus dna by in situ nucleic acid hybridization. | paraffin sections of 11 undifferentiated salivary gland carcinomas of lymphoepithelioma type (malignant lymphoepithelial lesion) arising in greenlandic eskimos (inuit) were examined for the presence of epstein-barr virus (ebv) using in situ nucleic acid hybridization with a 35s-labeled ebv-specific probe. epstein-barr virus genomes were detected in each case in malignant epithelial cells, but were not found in lymphoid stroma or in residual benign salivary epithelium. eight undifferentiated sali ... | 1991 | 1651284 |
| complementation of adenovirus early region 1a and 2a mutants by epstein-barr virus immortalized lymphoblastoid cell lines. | human b-lymphocytes may be infected by both adenoviruses and the epstein-barr virus (ebv). some of the immediate early and early proteins in the two viruses are similar in function even though their primary structures are different. as these viruses might infect the same b-cells in man, we asked if complementation could take place. the adenovirus mutant h5ts125 has a thermolabile dna-binding protein and is defective in dna replication at 39 degrees. several ebv-transformed human lymphoblastoid c ... | 1991 | 1651589 |
| cooperation of ebv dna polymerase and ea-d(bmrf1) in vitro and colocalization in nuclei of infected cells. | expression of the epstein-barr virus (ebv) dna polymerase (ebvpol) open reading frame (balf5) by in vitro transcription-translation yielded a 116-kda primary translation product. enzymatic dna polymerase activity of the in vitro translated polypeptide required the presence of the 47-kda bmrf1 (ea-d) gene product. antiserum raised to the balf5 gene product expressed in escherichia coli specifically precipitated a 116-kda polypeptide in extracts of latently infected lymphoblastoid cells induced fo ... | 1991 | 1651595 |
| parotid enlargement in children seropositive for human immunodeficiency virus: imaging findings. | we investigated the clinical, immunologic, and imaging features of parotid enlargement in 10 children seropositive for human immunodeficiency virus (hiv) who were infected prenatally. in seven patients, sonography revealed many small hypoechoic areas suggestive of lymphoid infiltration. in three older children, large anechoic areas suggesting lymphoepithelial cysts were present. the lesions probably represent generalized lymphoid infiltration akin to pulmonary lymphoid hyperplasia, although only ... | 1991 | 1651645 |
| use of dna-protein interaction to isolate specific genomic dna sequences. | we describe a simple and rapid method for the isolation of specific genomic dna sequences recognized by dna-binding proteins. this procedure consists of four steps: (1) restriction enzyme digestion and size fractionation of genomic dna; (2) dna--protein binding using the gel mobility-shift assay; (3) ligation of isolated dna fragments followed by transformation of escherichia coli; and (4) screening of recombinant clones for inserts containing specific dna--protein binding sequences. we have use ... | 1991 | 1651670 |
| phospholipase a2 activity in epstein-barr virus-transformed lymphoblast cells from schizophrenic patients. | we examined the activity of phospholipase a2 in epstein-barr virus-transformed lymphoblast cell lines established from ten schizophrenic patients and ten controls. a novel method for determination of enzyme activity in whole cells was employed, by measuring the hydrolysis of a fluorescent analogue of phosphatidylcholine. no significant difference in phospholipase a2 activity was found between the groups. these results suggest that the previously reported changes in phospholipase a2 activity in p ... | 1991 | 1651772 |
| epstein-barr virus antibody patterns preceding the diagnosis of nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) patients have elevated igg and iga antibody titers against the epstein-barr viral capsid antigen (vca) and the diffuse component of the early antigen complex (ea-d) at diagnosis. several studies have implied that the presence of anti-vca-iga can be used as a screening marker for early npc. to evaluate this further, we undertook a serologic case-control study based on four serum banks which together had specimens from over 240,000 persons. seven cases of undifferent ... | 1991 | 1651778 |
| spam-8, a mouse-human heteromyeloma fusion partner in the production of human monoclonal antibodies. establishment of a human monoclonal antibody against cytomegalovirus. | a heteromyeloma (mouse x human) cell line (spam-8) was produced by fusing mouse myeloma cells (sp2/0) with human peripheral blood lymphocytes. the cells were sensitive to aminopterin and resistant to ouabain. the cells showed a doubling time of about 19 hours and a cloning efficiency of 0.8 cells/well (to obtain growth in 50% of wells seeded) using mouse thymocytes as feeder cells. the number of chromosomes was about 86 and 1% of the total dna was of human origin. fusion of spam-8 cells with lym ... | 1991 | 1651784 |
| an immunoregulatory human monoclonal antibody in schistosomiasis japonica. | a series of human monoclonal antibodies were generated using splenocytes from a chinese patient with chronic schistosomiasis who had undergone splenectomy as part of a portacaval decompression operation. splenocytes were transformed in bulk culture by epstein barr virus and transformants fused with the hmma 2.11 tg/o cell line. twenty individual igg antiworm and egg antibody-producing hybridomas were generated and screened for antigen reactivity by western blot and for suppression of antigen-ind ... | 1991 | 1651785 |
| heterogeneity in both cytokine production and responsiveness of a panel of monoclonal human epstein-barr virus-transformed b-cell lines. | to optimize growth and ig production of in vitro-cultured epstein-barr virus (ebv)-transformed b cells, a panel of six monoclonal ebv b-cell lines was analyzed for autocrine growth factor production and responsiveness to various cytokines. three cell lines produced il-i and four produced il-6, although differences concerning the amount of lymphokines produced were observed. interestingly a considerable tumor necrosis factor beta (lymphotoxin) activity was found in supernatants of all cell lines. ... | 1991 | 1651786 |
| an igg human monoclonal antibody reactive with a surface membrane antigen expressed on malignant breast cancer cells. | a human igg3 monoclonal antibody (hmab), f86, that reacts with breast cancer cells was obtained by fusion of antibody-secreting epstein-barr virus (ebv)-transformed cells from a draining lymph node with the human fusion partner hmma2.11tg/o. f86 reacts with an antigen expressed on the surface of five malignant human breast cancer cell lines and several human malignant myelomonocytic cell lines but is not detected on normal peripheral blood mononuclear cells. studies with tissue sections of a hum ... | 1991 | 1651787 |
| parameters to enhance human hybridoma formation with hypoosmolar electrofusion. | hypoosmolar conditions have permitted the development of electrofusion techniques capable of producing human hybridomas from as few as 10(5) b cells. a hybridoma formation efficiency of one hybrid for each 125 input b cells has been achieved with epstein-barr virus--activated b cells and mouse-human heteromyelomas. this is at least 100-fold higher in efficiency than with polyethylene glycol-induced cell fusion, as well as a 50- to 100-fold decrease in the required number of human b cells. the ab ... | 1991 | 1651789 |
| b-cell lymphoproliferative disorders after bone marrow transplant. an analysis of ten cases with emphasis on epstein-barr virus detection by in situ hybridization. | ten patients with b-cell lymphoproliferative disorders (blpd) after bone marrow transplant were studied in a retrospective analysis of 81 specimens available from biopsy and autopsy material. histologic review, immunophenotyping, and in situ hybridization (ish) for epstein-barr virus (ebv) sequences were done. sixty-four specimens showed morphologic evidence of blpd, demonstrating a heterogeneous spectrum with various degrees of plasmacytoid differentiation. immunophenotypic evidence of clonalit ... | 1991 | 1651803 |
| familial aggregation of nasopharyngeal carcinoma and other malignancies. a clinicopathologic description. | nasopharyngeal carcinoma (npc) occurred in five members in three generations of a white american family of scandinavian descent. six other family members had malignancies including malignant melanoma, malignant lymphoma, squamous cell carcinoma of the tongue, adenocarcinoma of the colon, and asynchronous bilateral in situ and invasive ductal carcinomas of the breast. there was also a history of autoimmune disorders and exposure to smoke, fumes, and chemicals in some family members. regression an ... | 1991 | 1651806 |
| [associations between the renal tubular acidosis of primary sjogren syndrome and the infection of epstein-barr virus: a preliminary study]. | to explore the possible etiological associations between the infection of epstein-barr virus (ebv) and the occurrence of renal tubular acidosis (rta) of primary sjogren's syndrome (ss), renal biopsies from both primary ss with clinical or subclinical rta and controls were detected by using a monoclonal antibody against ebv early antigen p138 and a 32p-labelled ebv bam w probe. as a result, cytoplasmic fluorescence staining of epithelial cells with the monoclonal antibody as described above was n ... | 1991 | 1651835 |
| production and characterization of human monoclonal antibody recognizing the n-terminal residues of pseudomonas aeruginosa exotoxin a. | human cell lines producing monoclonal antibodies (mabs) against pseudomonas aeruginosa exotoxin a were established by ebv transformation followed by cell fusion. monoclonal antibody fk-001, igm (mu, kappa), was demonstrated to be specifically reactive with exotoxin a in elisa and immunoblotting, by recognizing n-terminal 16 amino acid residues of exotoxin a as an epitope. this epitope region belongs to domain i which is required for the binding of exotoxin a to the receptor on target cells. fk-0 ... | 1991 | 1651902 |
| detection of epstein-barr virus-dna in tongue epithelium of human immunodeficiency virus-infected patients. | oral hairy leukoplakia is a lesion on the lateral part of the tongue that contains replicating epstein-barr virus (ebv) and presages progression from human immunodeficiency virus (hiv) infection to aids. to clarify the role of ebv in the development of the lesions, we used filter in situ dna hybridization to determine the prevalence of ebv and of human papillomavirus (hpv) in epithelial cells obtained on swabs from the tongue of hiv-infected patients who had hairy leukoplakia, hiv-infected patie ... | 1991 | 1651968 |
| persistence of selectable herpesvirus saimiri in various human haematopoietic and epithelial cell lines. | herpesvirus (h.) saimiri, an infectious agent of squirrel monkeys, is capable of persisting in t lymphocytes of various primate species. it has been used as a vector for the functional analysis of regulatory genes in primary human t lymphocytes. as it is not yet known whether other cell types are capable of supporting viral persistence, various human cell lines were investigated using selectable h. saimiri recombinants. the lines chosen represent cells from the epithelium and connective tissue a ... | 1991 | 1651988 |
| quantitative analysis of the epstein-barr virus-inducing properties of short-chain fatty acids present in the culture fluids of oral bacteria. | the culture fluids of various anaerobic bacteria induced the synthesis of early antigens (ea) in epstein-barr virus (ebv) carrying lymphoblastoid cells. the culture fluids of corynebacterium butyricum and fusobacterium nucleatum were the effective inducer on ea. the inducing activity was, to some extent, dependent on their n-butyric acid content, but appeared to be regulated by yet unidentified materials. | 1991 | 1652240 |
| activation of epstein-barr virus replication in hodgkin and reed-sternberg cells. | recent evidence has shown that hodgkin's disease (hd) is associated with epstein-barr virus (ebv) in a substantial number of cases and that in these cases ebv dna is localized exclusively to hodgkin and reed-sternberg (rs) cells. the virus genome is not silent in rs cells because two ebv latent gene products, latent membrane protein (lmp) and eb early region (eber) transcripts, have recently been reported to be expressed in rs cells. however, little information is available about the possible ac ... | 1991 | 1652308 |
| [using immunofluorescence and immunoenzyme to detect eb virus associated antigen in labial gland biopsies from patients with sjogren's syndrome]. | | 1991 | 1652412 |
| induction of amyloid precursor protein mrna after heat shock in cultured human lymphoblastoid cells. | in an attempt to examine a possible relationship between heat shock stress and an induction of amyloid precursor protein, cultured lymphoblastoid cells established from 12 human subjects were treated with heat shock at 42 degrees c for 30 min. the levels of mrna for amyloid precursor protein (app), heat shock protein (hsp) 70, and actin were examined by northern blot at 1, 3, 8, 24, and 48 h after the heat shock treatment. hsp70 mrna was induced at 1 and 3 h, and became undetectable again by 8 h ... | 1991 | 1652710 |
| human immunodeficiency virus induction of malignant transformation in human b lymphocytes. | aggressive b-cell lymphomas are occurring with increasing incidence among individuals infected with human immunodeficiency virus (hiv). several lines of evidence implicate both epstein-barr virus (ebv) and c-myc activation in the pathogenesis of a major subset of these tumors. these observations prompted our investigation of interactions among ebv, c-myc, and hiv in primary b cells. we show that nonimmortalized peripheral b lymphocytes from ebv-seropositive, hiv-seronegative donors can be infect ... | 1991 | 1652756 |
| b-lineage phenotype of lymphoblastoid cell lines from patients with x-linked agammaglobulinemia. | epstein-barr virus (ebv)-induced precursor b-cell lines were established from bone marrow cells of patients with x-linked agammaglobulinemia (x-la). using seven b-lineage specific monoclonal antibodies marker profiles of these cell lines were examined in order to know developmental stage specific and/or x-la specific changes of b-cell related cell-surface antigens. cd19, cd20, cr2 (cd21), fc epsilon receptor (cd23) and hla-dr antigens were consistently found on the x-la derived precursor b-cell ... | 1991 | 1652799 |
| altered processing of human insulin by b lymphocytes from an immunologically insulin-resistant type i diabetic patient. | immunologically insulin resistant (iir) type i diabetic patients possess significantly elevated levels of anti-insulin serum autoantibodies. we investigated whether altered insulin processing by b lymphocytes contributes to this form of insulin resistance. a comparison was made of the 125i-labelled human insulin (hi) peptides processed by epstein-barr virus (ebv)-transformed b lymphocytes derived from hla-identical and nonidentical iir with non-iir type i diabetic patients on insulin therapy and ... | 1991 | 1652968 |
| hodgkin's disease revisited: reed-sternberg cells as natural hybridomas. | the formation of natural hybridomas during the course of malignant lymphoproliferative diseases was first observed in 1969, and many times thereafter. this natural phenomenon remains experimentally unexplored even though it exerts fundamental influence on the natural history and outcome of neoplastic cell proliferations. instead, hybridomas artificially constructed in the laboratory from 1975 on are being extensively studied and utilized for the production of highly specific monoclonal antibodie ... | 1991 | 1652972 |
| the c-fgr proto-oncogene: expression in epstein-barr-virus-infected b lymphocytes and in cells of the myelomonocytic and granulocytic lineages. | the c-fgr proto-oncogene, which is a member of the c-src gene family, encodes the cytoplasmic tyrosine kinase p55c-fgr. expression of the c-fgr gene is activated in human b lymphocytes following infection with epstein-barr virus, and the viral protein ebna-2 is involved in mediating this effect. the only normal cells in which the c-fgr gene is known to be expressed are peripheral-blood granulocytes and monocytes, and tissue macrophages. in accordance with this, levels of c-fgr mrna increase when ... | 1991 | 1652975 |
| evidence for molecular subtypes of hiv-associated lymphoma: division into peripheral monoclonal, polyclonal and central nervous system lymphoma. | the pathogenesis of the hiv-associated lymphomas is not well understood. in order to begin characterizing this class of lymphoma, we initiated a molecular genetic study of dna extracted from 31 diagnostic biopsy specimens from patients diagnosed with aids-associated non-hodgkin's lymphoma. analysis of 25 peripheral lymphomas showed that 14 were monoclonal b-cell processes, while 11 appeared to be of polyclonal origin. five of the 14 monoclonal lymphomas were found to have rearrangements of the c ... | 1991 | 1652978 |
| epstein-barr virus gene expression in hodgkin's disease. | | 1991 | 1653064 |
| mass spectrometric identification of a phorbol diester 12-o-hexadecanoylphorbol-13-acetate, an epstein-barr virus-activating substance, in the soil collected from under sapium sebiferum. | soil-extracts collected from the ground from under several euphorbiaceae plants have been known to possess epstein-barr virus (ebv)-activating substances which are thought to be one of the environmental co-factors causing nasopharyngeal carcinoma (npc) in southern part of china and burkitt's lymphoma (bl) in tropical africa. then, a model experiment aimed at chemical characterization of such active substances was carried out using a soil-extract around sapium sebiferum, a japanese representative ... | 1991 | 1653107 |
| inhibitory effects of 3-nitro-2,4,6-trihydroxybenzamides on epstein-barr virus early antigen induction. | inhibitory effects of a series of 3-nitro-2,4,6-trihydroxybenzamides on epstein-barr virus early antigen (ebv-ea) induction were examined using raji cells. some of the tested compounds showed highly inhibitory activity, the n-octyl amide derivative being the most active among them. these results suggest the possibility that 3-nitro-2,4,6-trihydroxybenzamides might be listed as novel inhibitors of tumor promotion. | 1991 | 1653108 |
| evaluation of a synthetic-peptide enzyme-linked immunosorbent assay for immunoglobulin m to human parvovirus b19. | a synthetic peptide corresponding to a part of the virus protein 1-virus protein 2 overlapping region of human parvovirus b19 was used in an indirect enzyme-linked immunosorbent assay. antibodies of the immunoglobulin (ig) m class were measured in serum samples from patients with erythema infectiosum and controls. in comparison with an igm assay using native b19 viral antigen, the peptide antigen assay was 92% sensitive and 87% specific. b19 igm reactivities were seen in a limited number of chil ... | 1991 | 1653264 |
| modulation of lfa-1 surface antigen expression by activated h-ras oncogene in ebv-infected human b-lymphoblast cells. | the lymphocyte-associated antigen 1 (lfa-1) involved in a wide range of cellular adhesion-dependent immunological functions, including interaction of cytotoxic t lymphocytes with their target, is implicated in tumorigenesis. the modulation of the lfa-1 antigen expression was studied in epstein-barr virus (ebv)-immortalized human b-lymphoblastoid cell lines, transfected with human oncogenes, h-ras and c-myc. we observed by flow cytometry that the activated h-ras (ej) gene, but not its normal coun ... | 1991 | 1653411 |
| association of epstein-barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration. lymphoepithelioma-like carcinoma. | some undifferentiated gastric carcinomas with intense lymphoid infiltration have a striking resemblance to nasopharyngeal lymphoepithelioma. the authors identified eight such cases (seven patients from japan and one from the united states) of undifferentiated gastric carcinoma (lymphoepithelioma-like carcinoma [lelc]) and examined them for epstein-barr (ebv) viral sequences using polymerase chain reaction (pcr) and in situ hybridization (ish) techniques. ebv was detected in seven of the eight ca ... | 1991 | 1653517 |
| the oncogenic potential of epstein-barr virus. | epstein-barr (eb) virus is a herpesvirus which is the causative agent of infectious mononucleosis. it can also be classified as a human dna tumor virus as it is also etiologically associated with the development of burkitt's lymphoma (bl) and nasopharyngeal carcinoma. eb virus involvement in these human tumors is suggested by seroepidemiological studies and the detection of virus dna and proteins in tumor biopsies. furthermore, eb virus can be detected in lymphoproliferations and malignant tumor ... | 1991 | 1653621 |
| the rapid diagnosis of infectious mononucleosis using an elisa that detects igm antibody to a peptide component of epstein-barr virus nuclear antigen. | an enzyme-linked immunosorbent assay (elisa) that detects igm antibody to a peptide component of the epstein-barr virus (ebv) nuclear antigen (ebna-1) was compared with a conventional rapid heterophil antibody method for the rapid diagnosis of infectious mononucleosis. discrepancies between the two methods were further analyzed using an indirect immunofluorescence assay to detect antibodies to ebv antigens. we evaluated 298 cases of suspected infectious mononucleosis. the elisa was very sensitiv ... | 1991 | 1653677 |
| prevalence of antibodies to human herpesviruses and hepatitis b virus in patients at different stages of human immunodeficiency virus (hiv) infection. | the results of antibody assays for viruses of the herpes group (hsv, ebv, vzv and cmv) and for hepatitis b virus (hbv) were retrospectively evaluated in 439 hiv-seropositive patients classified into different stages of hiv infection. the prevalence of specific igg, igm and iga antibodies in these groups was compared with that of a control group of hiv-negative unselected hospital patients. antibodies to herpes viruses and hbv were more prevalent amongst hiv-seropositives, especially las and aids ... | 1991 | 1653770 |
| detection of epstein-barr virus genomes in aids related lymphomas: sensitivity and specificity of in situ hybridisation compared with southern blotting. | eighteen cases of aids related, non-hodgkin's lymphomas were examined for the presence of epstein-barr virus (ebv) genomes using in situ hybridisation with a 35s-labelled probe. the results were compared with those obtained independently by southern blot analysis with a 32p-labelled probe of frozen tissue from the same tumours. technically satisfactory results were obtained with both methods in 15 lymphomas. ebv dna was detected in seven of 15 (47%) cases by in situ hybridisation and in eight of ... | 1991 | 1653789 |
| the latent membrane protein-1 in epstein-barr virus-transformed lymphoblastoid cells is found with ubiquitin-protein conjugates and heat-shock protein 70 in lysosomes oriented around the microtubule organizing centre. | immunofluorescence studies on epstein-barr virus (ebv)-transformed lymphoblastoid cells have previously shown that the latent membrane transforming protein (lmp-1) is found in patch-like inclusions which also immunostain for vimentin. we now show that ebv transformation causes a major reorganization of intermediate filaments, microtubules, mitochondria, and lysosomal elements, which generally become oriented around the microtubule organizing centre. immunogold electron microscopy shows that lmp- ... | 1991 | 1653831 |
| [epstein-barr virus (ebv) in lymphoproliferative diseases]. | the results of dna or rna study in ebv-associated lymphoproliferative diseases were shown. for detecting ebv dna, southern blot analysis with bam hiw probe (internal repeat) and non-repeat (least often deleted) probe are used. probes close to (ex. lmp) or within terminal repeat can indicate clonality in terms of junctional structure. several such examples were shown, in which benign polyclonal ebv (+) cd3 + 8+ lymphocytes, ebv (+) cd3 + 4 - 8- granulay lymphocytosis, ebv (+) t(14, 22) b-cell lym ... | 1991 | 1653862 |
| transverse myelitis and epstein-barr virus infection with delayed antibody responses. | | 1991 | 1653917 |
| rapid detection of epstein-barr viral dna by nonisotopic in situ hybridization. correlation with the polymerase chain reaction. | a nonisotopic, in situ hybridization procedure is described for detecting epstein-barr viral (ebv) dna in cytopreparations of pepsin-digested, unfixed cells in less than 3 hours. the procedure, which uses an ebv bam hi w dna probe conjugated directly to horseradish peroxidase, first was optimized using an ebv-infected cell line (arh-77) and then validated on four positive control specimens and six negative control specimens. optimization studies demonstrated distinct nuclear hybridization signal ... | 1991 | 1654024 |
| viral involvement in hodgkin's disease: detection of clonal type a epstein-barr virus genomes in tumour samples. | thirty-five cases of hodgkin's disease (hd) were analysed for the presence of epstein-barr virus (ebv) and human herpesvirus-6 (hhv-6) dna. ebv genomes were detected in 11/35 cases while none of the cases was positive for hhv-6. ten of the ebv-positive cases were subsequently analysed using a probe for the terminal region of the virus; the results suggested that the ebv-infected cells were clonally expanded. ebv subtypes specific dna amplification was used to demonstrate that ebv subtype a, and ... | 1991 | 1654072 |
| in vivo expression of il-1 beta and il-6 genes during viral infections in human. | macrophage infiltration is a constant feature of human virus-infected tissues. however, the in situ functional status of these cells remains undetermined. in order to document an activation of macrophages in virus-infected tissues, the expression of il-1 beta and il-6 genes was analyzed using in situ hybridization. several tissues were studied, as well as infections induced by different viruses: lymph nodes infected by hiv-1 (9 cases) or ebv (one case), lungs infected by cmv (5 cases) or adenovi ... | 1991 | 1654144 |
| isolation of human herpesvirus-6 (hhv-6) from patients with collagen vascular diseases. | the prevalence and activity of human herpesvirus-6 in patients with collagen vascular diseases (cvd) was determined. one hundred and fifty patients with cvd (56 with systemic lupus erythematosus-sle, 92 with rheumatoid arthritis-ra, 1 with sharp's syndrome and 1 with atypical polyclonal lymphoproliferation-apl and rheumatoid features) were screened serologically (ifa and elisa) for antibodies against human herpesvirus-6 (hhv-6), epstein-barr virus (ebv) and cytomegalovirus (cmv). virus isolation ... | 1991 | 1654147 |
| human herpesvirus-6 infection may predispose cells to superinfection by other viruses. | double infection of cells by hhv-6, epstein-barr virus (ebv) and by human immunodeficiency virus (hiv-1) can enhance viral effects though genetic transactivation. it remained to be clarified, however, by which mechanism different viruses may enter the same cell. we have shown that hhv-6 infection of immature lymphoid cells rigidifies the cytoplasmic membrane and causes receptor proteins for viruses such as cd4 for hiv-1 and cr2 for ebv to be expressed. in our experiments, hhv-6 infected cells we ... | 1991 | 1654148 |
| frequent double infection with epstein-barr virus and human herpesvirus-6 in patients with acute infectious mononucleosis. | clinical infectious mononucleosis (im) represents a benign self-limited form of lymphoproliferative disease which is usually caused by infection with epstein-barr virus (ebv). microscopic characteristics of this lymphoproliferative disorder, however, are not ultimately specific for ebv infection, but can also be seen in infections with other lymphotropic viruses, especially of the herpesvirus family. human herpesvirus-6 (hhv-6) infection can apparently be associated with a number of diseases als ... | 1991 | 1654150 |
| stress-related activation of epstein-barr virus. | herpesviruses characteristically persist in a latent state in the body over the lifetime of an individual. under certain conditions, any one of the herpesviruses can be reactivated. the mechanisms underlying the establishment of latent virus infection or viral reactivation are not well understood; however, it is known that the cellular immune response plays a very important role in the maintenance of latency and in virus reactivation. one of the factors thought to be associated with the reactiva ... | 1991 | 1654167 |
| stimulation with allogeneic epstein-barr virus-transformed lymphoblastoid cell lines generates hla class i-specific ctls with different target cell avidity. | epstein-barr virus (ebv) transformed lymphoblastoid cell lines (lcl) are potent inducers of cytotoxic t-lymphocytes (ctl) in allogeneic mixed lymphocyte cultures (mlc). the contribution of ebv antigens to the induction of cytotoxic responses was investigated by comparing ctl clones derived from allogeneic mlcs of lymphocytes from one ebv seropositive and one seronegative donor for their capacity to lyse paired ebv positive and negative targets. the majority of the clones showed a conventional "h ... | 1991 | 1654213 |
| diagnosis of human herpesviruses: memorandum from a who meeting. | the frequent reactivation of disease in immunosuppressed patients represents a serious health complication for acquired immunodeficiency syndrome (aids) patients with herpesviruses. since the herpesviruses are often associated with the development of complication such as pneumonia and lymphoma, an emphasis is being placed on the rapid laboratory diagnosis of herpes simplex viruses 1 and 2, varicella- zoster, epstein-barr virus, and cytomegalovirus. diagnostic methods that utilize monoclonal an ... | 1991 | 1654224 |
| lack of effect of peroral acyclovir for the treatment of acute infectious mononucleosis. | perorally administered acyclovir was evaluated in the therapy of acute infectious mononucleosis in a multicentered, randomized, double-blind, placebo-controlled trial. a total of 120 patients received 600 mg of acyclovir or placebo five times daily for 10 days. all patients were entered into the study within 7 days of symptom onset and had a positive monospot test. analysis of mean values and time to resolution of fever, lymphadenopathy, weight change, hepatomegaly, splenomegaly, liver function ... | 1991 | 1654364 |
| identification of the human herpesvirus 6 glycoprotein h and putative large tegument protein genes. | determination of the nucleotide sequences of two molecular clones of human herpesvirus 6 (hhv-6) (strain gs) and comparison with those of human cytomegalovirus (hcmv) has allowed the identification of the genes for the glycoprotein h (gh) and the putative large tegument protein of hhv-6. two molecular clones of fragments of hhv-6, the bamhi-g fragment (7,981 bp) of the clone termed pzvb43 and a hindiii fragment (8,717 bp) of the clone termed pzvh14, represent approximately 10% of the hhv-6 genom ... | 1991 | 1654455 |
| the leukemic b-cell population of patients with monoclonal lymphocytosis of undetermined significance (mlus) are functionally distinct from the chronic lymphocytic leukemia (cll) derived cell population. | some patients with cll survive for decades with a stable lymphocytosis without other signs of progression of the disease. this condition has been termed monoclonal lymphocytosis of undetermined significance (mlus). the aim of the present study was to search for functional differences between the monoclonal b-cell population of cll (n = 3) and mlus (n = 5) patients. mlus derived b-cell populations were susceptible to epstein-barr virus (ebv) infection measured as the production of eb nuclear anti ... | 1991 | 1654482 |
| epstein-barr virus infection acquired from a cadaveric renal transplant. | a 42-year-old man, seronegative for epstein-barr virus (ebv), received a cadaveric renal transplant. serology from the 27-year-old male donor indicated an active ebv infection. following treatment for acute rejection with okt3 the recipient developed a severe systemic illness. clinical features strongly suggested an acute ebv infection and serology showed seroconversion for ebv. the patient died and autopsy histology revealed widespread polymorphic lymphocyte infiltration in lymph nodes and soli ... | 1991 | 1654528 |
| infectious mononucleosis in the university hospital of the west indies. | the clinical features and laboratory parameters in sixteen confirmed cases of infectious mononucleosis (im) seen at the university hospital of the west indies between 1975 and 1989 were reviewed. the common presenting features were lymphadenopathy (14/16), fever (13/16) and pharyngitis (7/16). atypical lymphocytosis was present in 10 cases and heterophile antibodies (ha) in 9 cases. the aetiology and laboratory diagnosis of im are briefly discussed. | 1991 | 1654676 |
| infection as a cause of arthritis. | the etiology of most rheumatic tissues is unknown; however, recent investigation into this area is rapidly providing new clues to the pathogenesis of many of these diseases. this article reviews several infectious agents (epstein-barr virus, parvoviruses, and mycobacteria) and the data supporting their roles in the etiology of rheumatoid arthritis. in addition, current data on the potential roles of epstein-barr virus and retroviruses in the etiologies of sjögren's syndrome and kawasaki disease ... | 1991 | 1654973 |
| nasopharyngeal carcinoma in accra. | a higher prevalence of nasopharyngeal carcinoma (npc) among ghanaian children, adolescents and young adults is demonstrated in this study. in view of the known association between epstein-barr virus (ebv) and npc on the one hand, and the virus and burkitt's lymphoma (bl) on the other, it is suggested that the occurrence of both malignancies in younger subjects in this study points to the possible role of early infection with ebv in the aetiopathogenesis of npc. | 1991 | 1654999 |