| igf-1 and igfbp in congenital and acquired hypothyroidism after long-term replacement treatment. | thyroid hormones are involved in the regulation of the gh/igf axis. hypothyroidism is associated with a reduction in gh pulsatility and in gh-response to stimulatory tests. in hypothyroidism, serum levels of igf-1 and igfbp-3 fall and these changes are reversed after short term replacement with l-t4. this study was undertaken to determine the effect of long term replacement therapy with t4 in igf-1 and igfbp-3 serum levels. | 1999 | 10941423 |
| [parasigmoid abscess revealed by anaerobic osteomyelitis]. | we report the case of a 66 year-old-patient, who profited by a laminectomy t4 to t7 for spinal cord compression due to an osteomyelitis. bacteriological samples showed positives gram cocci and bacteroides fragilis by the culture. the systematic research of a primitive source permitted to find a parasigmoidis abscess, which was treated by a sigmoidectomy with a colorectal anastomosis. | 2000 | 10941448 |
| survival of patients with resected n2 non-small-cell lung cancer: evidence for a subclassification and implications. | patients who suffer from non-small-cell lung cancer (nsclc) with ipsilateral mediastinal lymph node involvement (n2) belong to a heterogeneous subgroup of patients. we analyzed the prognosis of patients with resected n2 nsclc to propose homogeneous patient subgroups. | 2000 | 10944131 |
| measured and calculated effects of mutations in bacteriophage t4 lysozyme on interactions in solution. | understanding the molecular determinants of protein interactions in solution has fundamental implications for understanding protein solution thermodynamics and, hence, processes as diverse as separations performance and cellular self-organization. our earlier theoretical calculations indicate that the protein-protein interactions are dominated by a small number of configurations in which highly complementary surface regions are apposed, rather than by the overall colloidal interactions. to exami ... | 2000 | 10944399 |
| [concurrent chemoradiotherapy for t4 and/or m1 lym squamous cell carcinoma of the esophagus]. | a phase ii study was conducted to investigate the efficacy and feasibility of chemoradiotherapy for locally advanced carcinoma of the esophagus. fifty-four patients with clinical t4 and/or m1 lym squamous cell carcinoma of the esophagus were enrolled. patients received protracted infusions of fluorouracil 400 mg/m2/24 hours on days 1 to 5 and 8 to 12, 2-hour infusions of cisplatin 40 mg/m2 on days 1 and 8, and concurrent radiotherapy at a dose of 30 gy in 15 fractions over 3 weeks. filgrastim wa ... | 2000 | 10945013 |
| three-dimensional structural views of damaged-dna recognition: t4 endonuclease v, e. coli vsr protein, and human nucleotide excision repair factor xpa. | genetic information is frequently disturbed by introduction of modified or mismatch bases into duplex dna, and hence all organisms contain dna repair systems to restore normal genetic information by removing such damaged bases or nucleotides and replacing them by correct ones. the understanding of this repair mechanism is a central subject in cell biology. this review focuses on the three-dimensional structural views of damaged dna recognition by three proteins. the first protein is t4 endonucle ... | 2000 | 10946233 |
| the hypothalamic-pituitary-thyroid negative feedback control axis in children with treated congenital hypothyroidism. | measurements of serum concentrations of free t4, t3, tsh, and thyroglobulin (tg) were conducted in 42 infants (2-9 months of age) detected and treated through the northwest newborn regional screening program and 63 children and adolescents (1-18 yr of age) with congenital hypothyroidism (ch) detected and managed in the northern california kaiser permanente medical care program. normal feedback control axis data were developed by quest diagnostics, inc. - nichols institute diagnostics and loma li ... | 2000 | 10946871 |
| an elevation of serum immunoglobulin e provides a new aspect of hyperthyroid graves' disease. | in hyperthyroid graves' disease, short-term methimazole is sufficient to induce lasting remission in some patients, but even long-term treatment fails to do so in others. we have evaluated the role of autoimmune abnormalities in the helper t cell type 2 (th2)-interleukin-13 (il-13)-tsh receptor system in maintaining hyperthyroidism by comparing ige levels in patients with various thyroid diseases. one hundred and ninety-three patients with hyperthyroid graves' disease were treated with methimazo ... | 2000 | 10946880 |
| familial dysalbuminemic hyperthyroxinemia in a swiss family caused by a mutant albumin (r218p) shows an apparent discrepancy between serum concentration and affinity for thyroxine. | familial dysalbuminemic hyperthyroxinemia (fdh), is the most common cause of inherited increase in serum total t4 (tt4) in the caucasian population. it is caused by a mutation (r218h) in the human serum albumin (hsa) gene, resulting in 10-fold higher affinity for t4 and, in heterozygous affected subjects, a tt4 level 2-fold higher than that in subjects expressing the wild-type hsa only. we now report fdh in a swiss family, caused by hsa r218p, previously reported in subjects of japanese origin. ... | 2000 | 10946882 |
| characterization of the uridine diphosphate-glucuronosyltransferase-catalyzing thyroid hormone glucuronidation in man. | increased thyroid hormone glucuronidation in rats caused by exposure to xenobiotics has stimulated a search for the individual uridine diphosphate-glucuronosyltransferases (ugts) catalyzing this reaction in rats and man. microsomal preparations from crigler-najjar liver, normal human liver, and kidney have been used to try to identify the ugt isoforms responsible for glucuronidation of the thyroid hormones. the predominant thyroid hormone released from the thyroid gland, t4, and the inactive rt3 ... | 2000 | 10946897 |
| reevaluation of nonphytate phosphorus requirement of growing pullets with and without phytase. | an experiment was conducted to re-evaluate the nonphytate phosphorus (npp) requirement of growing pullets and to determine to what extent this requirement could be reduced by phytase. six diets in a 3 x 2 factorial design were used. the pullets of the control group (t1) were fed a sequence of 0.4-0.35-0.3% npp for the age periods of 0 to 6, 6 to 12, and 12 to 18 wk, respectively, according to nrc (1994) recommendation. the npp level was reduced by an increment of 0.1% in each phase in t2 and t3. ... | 2000 | 10947183 |
| transcriptional repression of trh promoter function by t3: analysis by in vivo gene transfer. | we consider how an integrated in vivo model can be used to study the specific transcriptional effects of specific receptors in neuroendocrine systems. our example is the role of thyroid receptor (tr) isoforms in mediating negative feedback effects of t3 on trh (thyrotropin releasing hormone) expression. the in vivo transfection method employed polyethylenimine (pei) to introduce genes directly into specific regions of the brains of mice, rats, and xenopus tadpoles. in the mouse model, the techni ... | 2000 | 10949071 |
| vitamin e supplementation attenuates leakage of enzymes following 6 successive days of running training. | the purpose of this study was to examine whether vitamin e supplementation in humans would attenuate an increase of serum enzymes as an indirect marker of muscle damage following a sudden large increase in the running distance in a 6-day running training or not. a randomized and placebo-controlled study was carried out on fourteen male runners who were supplied vitamin e (alpha-tocopherol 1200 iu x day(-1); e) or placebo (p) 4 weeks prior to (t1) and during 6 successive days of running training ... | 2000 | 10950448 |
| interaction of methyl green with an oligonucleotide in intramolecular duplex and triplex conformations. circular dichroism studies. | interaction of methyl green with the oligonucleotide 5-dggaaaagg-[t4]-ggaaaagg-[t4]-ccttttcc (where [t4] is a nucleotide sequence of four thymines) in hairpin duplex and in intramolecular triplex structures has been studied by circular dichroism. we found that methyl green binding to the duplex form shows a complex pattern, exhibiting an exciton contribution when the number of bound molecules increases. differences between this pattern and previously published results on other dnas reveals the p ... | 1998 | 10950636 |
| gemcitabine plus vinorelbine as first-line chemotherapy in advanced nonsmall cell lung carcinoma a phase ii trial. | response and survival in patients with advanced or metastatic nonsmall cell lung carcinoma (nsclc) remain poor. as single agents, the nucleoside analog gemcitabine, and the semisynthetic vinca alkaloid vinorelbine, have been shown to be effective in nsclc and to have a low toxicity profile. | 2000 | 10951338 |
| pleuropulmonary and cardiovascular consequences of thoracoscopy performed in healthy standing horses. | six healthy, awake, and pharmacologically restrained mature horses were studied in order to define the changes in cardiopulmonary function during and after exploratory thoracoscopy and to determine the presence of postoperative complications occurring 48 hours after thoracoscopy. in a randomised 3 x 3 latin square design with 2 replications, 18 procedures were performed: 6 right (rth) and 6 left thoracoscopies (lth) and 6 sham procedures (sth). prior to each procedure a physical examination and ... | 2000 | 10952375 |
| [thyroid gland nodules registered at the endocrinology department of the medical center in prokuplje]. | thyroid nodules are often found in clinical practice. general population prevalence is about 4%, whereas in women it is over 6%. the basic disorder of cell kinetics of thyroid tumors is inappropriate growth response to corresponding thyroid-stimulating hormone (tsh) concentration. | 2000 | 10953554 |
| [quality control in surgery of locally advanced rectal cancer]. | the role of surgery in the therapeutic balance of locally advanced rectal neoplasms needs to be redefined in the light of recent reports on the efficacy of radio- and chemotherapy in neoadjuvant treatment. | 2000 | 10953562 |
| [prognostic factors in gastric cancer. our experience and review of the literature]. | this review of the latest literature and retrospective analysis of the authors' series aimed to identify the most relevant prognostic factors for gastric cancer. | 2000 | 10953563 |
| [effect of diabetes in the first year after gastric banding]. | initial hormonal and metabolic investigation was performed in a group o 51 patients (mean age 41 years and body mass index--bmi 45.1 kg/m2) referred to gastric banding for morbid obesity. patients were followed for one year period after surgery. using multiple linear regression following parameters influencing bmi change were identified. negative influence on bmi reduction: high insulin, presence of diabetes, low t3/t4 ratio. positive influence on bmi reduction high triglycerides level, positive ... | 2000 | 10953636 |
| treatment of hypopituitarism in infancy. effect on head circumference growth. | head circumference of children with multiple pituitary-hormone deficiency (mphd) may be subnormal for age. moreover it is known that linear growth in infancy is growth-hormone (gh) dependent. therefore, aim of the study has been to compare head circumference measurements in children with hypopituitarism after l-thyroxine (l-t4) therapy alone, before therapy with gh, and after gh was added to the therapy. | 1999 | 10953724 |
| [the value of spiral ct in the staging of carcinomas of the oral cavity and of the oro- and hypopharynx]. | to compare spiral and conventional ct in the staging of carcinomas of the oral cavity, the oropharynx and hypopharynx. | 2000 | 10955294 |
| morphological and functional development of the thyroid tissue in rainbow trout (oncorhynchus mykiss) embryos. | the development of the thyroid tissue in rainbow trout (oncorhynchus mykiss) embryos between 20 and 88 days postfertilization (dpf) was studied using traditional histological methods in combination with immunostaining using antibodies raised against l-thyroxine (t4) and triiodo-l-thyronine (t3). in 20 dpf embryos, the thyroid primordium appeared as a simple tube aligned with the dorsal surface of the ventral aorta. the tubular primordium becomes progressively bifurcated at each end and follicles ... | 2000 | 10955719 |
| peripheral metabolism of thyroid hormones: a review. | peripheral metabolism of thyroid hormones is a critical component of the impact these hormones have on intracellular function. thyroid hormones can be metabolized in peripheral tissue by deiodination, conjugation, deamination, and decarboxylation enzyme reactions. therefore, alterations in these metabolic pathways might significantly impact the quantity of specific thyroid hormone metabolites influencing function at the cellular level. available evidence also suggests that, under some circumstan ... | 2000 | 10956378 |
| natural variation in the amino acid sequence around the hiv type 1 glycoprotein 160 cleavage site and its effect on cleavability, subunit association, and membrane fusion. | to assess the natural variation of the structure of the cleavage site as well as the n-terminal region of gp41 for the cytopathogenicity of hiv-1, syncytium-inducing (si) and non-syncytium-inducing (nsi) virus isolates were obtained from hiv-1-infected patients. in addition, the coreceptor usage of the isolates was determined by infection of primary macrophages and pm-1 cells. dna sequences encoding the c-terminal 41 amino acid residues of gp120 and the 64 amino acid n-terminal residues of gp41 ... | 2000 | 10957721 |
| the use of resolvases t4 endonuclease vii and t7 endonuclease i in mutation detection. | | 2000 | 10957979 |
| the prevalence and clinical significance of blocking thyrotropin receptor antibodies in untreated hyperthyroid graves' disease. | the goal of this study was to evaluate the clinical significance of the blocking thyrotropin receptor antibodies (tshrab) in graves' disease. the amount of blocking and stimulating tshrab were measured in 200 patients with untreated hyperthyroid graves' disease using several cell lines carrying different tshr chimera. stimulating tshrab were measured in chinese hamster ovary (cho) cells with wild-type human tshr (cho-htshr) or a tshr chimera with residues 90-165 (mc2) or 8-165 (mc1+2) substitute ... | 2000 | 10958310 |
| parasitic thyroid nodule in a patient with hashimoto's chronic thyroiditis. | a case of parasitic thyroid nodule is presented. the patient was a non symptomatic 53-year-old white woman, on irregular course of l-thyroxine to treat hypothyroidism due to hashimoto's thyroiditis. without a history of thyroid trauma or surgery, she presented a 1.6 x 0.7 x 0.5cm right pre-laryngeal lymph node-like mass which, on ultrasonography, appeared distinct from the gland. tsh, thyroid peroxidase antibody and thyroglobulin antibody serum levels were elevated and t4-free level was normal. ... | 2000 | 10959126 |
| increased angiogenin expression in gastric cancer correlated with cancer progression. | the purpose of this study is to elucidate the expression of angiogenin and its previously undemonstrated clinical significance in gastric cancer (gc). | 2000 | 10961390 |
| video-assisted transthoracic sympathectomy in the treatment of primary hyperhidrosis: friend or foe? | the authors hypothesize that palmar hyperhidrosis is a systemic manifestation of abnormal sudomotor function; consequently, thoracoscopic sympathectomy to alleviate symptoms in the hands may result in heat dissipation because sweating is transferred to other sites. to investigate this phenomenon and to determine whether it adversely affects patient satisfaction, a standard questionnaire was administered to 626 patients who underwent sympathectomy at a university-associated public hospital betwee ... | 2000 | 10961751 |
| bladder neck involvement at radical prostatectomy: positive margins or advanced t4 disease? | to assess the prognosis of patients with bladder neck (bn) involvement in radical prostatectomy specimens and compare it with patients with seminal vesicle invasion (svi) presumed to have an inferior stage according to the tnm classification. | 2000 | 10962313 |
| neurophysiological follow-up of motor cortical output in stroke patients. | transcranial magnetic stimulation (tms) has been employed in following up a population of 20 stroke patients in a post-acute, apparently stabilized stage. neurophysiological and clinical data were recorded in 5 different recording sessions, from the beginning of a neuro-rehabilitation treatment (t0, at about 5 weeks from the ictal event.), followed up for about 4 months (t4), with the purpose to study any modification of the cortical motor output in the course of a neuro-rehabilitation treatment ... | 2000 | 10964084 |
| the assessment of risk to acquired hypothyroidism from exposure to pcbs: a study among akwesasne mohawk women. | pcbs are a family of 209 chemical compounds, each of which consists of two benzene rings and 1 to 10 chlorine atoms. their long-term stability and dispersion into the environment and the food chain have caused concern about their impact on humans and the environment. native american communities are believed to be at particularly high risk of such exposure since they typically are more dependent than other populations on local fish and game as a food source. we have evidence for a significant exc ... | 2000 | 10965441 |
| epidermal growth factor receptor, muc-1 and muc-2 in bladder cancer. | the aim of this study was to investigate the immunohistochemical expression of epidermal growth factor receptor (egfr), mucin-1 (muc-1) and mucin-2 (muc-2) proteins in primary bladder carcinomas and to compare egfr and muc staining patterns with the histological findings, grade and stage of bladder carcinoma. fifty-six surgical specimens obtained from superficial and deeply invasive bladder carcinomas were studied. of the 56 bladder tumors 42 (75%) expressed egfr, 34 (60.71%) muc-1 and 15 (26.78 ... | 2000 | 10965823 |
| transthyretin regulates thyroid hormone levels in the choroid plexus, but not in the brain parenchyma: study in a transthyretin-null mouse model. | transthyretin (ttr) is the major t4-binding protein in rodents. using a ttr-null mouse model we asked the following questions. 1) do other t4 binding moieties replace ttr in the cerebrospinal fluid (csf)? 2) are the low whole brain total t4 levels found in this mouse model associated with hypothyroidism, e.g. increased 5'-deiodinase type 2 (d2) activity and rc3-neurogranin messenger rna levels? 3) which brain regions account for the decreased total whole brain t4 levels? 4) are there changes in ... | 2000 | 10965897 |
| serum levels of the cytokines il-1beta, il-6 and icam-1 after 131i-treatment of graves' disease and nodular goiter. | cytokines might be involved in the immunological flare up, seen in some patients after 131i-treatment. therefore, we measured serum levels of interleukin-6 (il-6), interleukin-1beta (il-1beta), interleukin-6 soluble receptor (il-6sr) and intercellular-adhesion-molecule-1 (icam-1) as well as tumor necrosis factor (tnf-alpha) after 131i-treatment of graves' disease and nodular goiter. seven patients with graves' disease, eight with toxic nodular goiter and seven with non-toxic nodular goiter, were ... | 2000 | 10965935 |
| surgical management of malignant melanoma using dynamic lymphoscintigraphy and gamma probe-guided sentinel lymph node biopsy: the emory experience. | sentinel lymph node (sln) biopsy is revolutionizing the surgical management of primary malignant melanoma. it allows accurate nodal staging which targets patients who may benefit from regional lymphadenectomy and systemic therapy. this is a retrospective review of patients treated at emory university for stage i and ii malignant melanoma with gamma probe-guided sln biopsy from 1/1/94 to 6/30/98. three hundred sixty patients (males 228, females 132) were identified. primary melanoma sites include ... | 2000 | 10966037 |
| coupling of open reading frames by translational bypassing. | translational bypassing joins the information found within two disparate open reading frames into a single polypeptide chain. the underlying mechanism centers on the decoding properties of peptidyl-transfer rna (trna) and involves three stages: take-off, scanning, and landing. in take-off, the peptidyl-trna/messenger rna (mrna) complex in the p site of the ribosome dissociates, and the mrna begins to move through the ribosome. in scanning, the peptidyl-trna probes the mrna sliding through the de ... | 2000 | 10966462 |
| structure of bacteriophage t4 gene product 11, the interface between the baseplate and short tail fibers. | bacteriophage t4, like all other viruses, is required to be stable while being transmitted from host to host, but also is poised to eject efficiently and rapidly its double-stranded dna genome to initiate infection. the latter is coordinated by the recognition of receptors on escherichia coli cells by the long tail fibers and subsequent irreversible attachment by the short tail fibers. these fibers are attached to the baseplate, a multi-subunit assembly at the distal end of the tail. recognition ... | 2000 | 10966799 |
| biochemical characterization of an atpase activity associated with the large packaging subunit gp17 from bacteriophage t4. | double-stranded dna-packaging in icosahedral bacteriophages is believed to be driven by a packaging "machine" constituted by the portal protein and the two packaging/terminase proteins assembled at the unique portal vertex of the empty prohead shell. although atp hydrolysis is evidently the principal driving force, which component of the packaging machinery functions as the translocating atpase has not been elucidated. evidence suggests that the large packaging subunit is a strong candidate for ... | 2000 | 10967092 |
| neuro-cognitive activity during a self-paced visuospatial task: comparative eeg profiles in marksmen and novice shooters. | log-transformed eeg power spectral estimates (6-7, 9,10-11,18-22, and 36-44 hz), obtained from skilled marksmen and novice shooters at sites f3, f4, c3, c4,t3, t4, p3, p4, o1, and o2 during the aiming period (6 s) of a target shooting task for each of 40 trials up to the moment of trigger pull, were contrasted to determine regional differences in cortical activation. the eeg power obtained from both groups during the preparatory aiming period was also compared to that observed for a similar time ... | 2000 | 10967230 |
| clinical staging of esophageal carcinoma. ct, eus, and pet. | ct is readily available to all patients. it is relatively inexpensive and fees are usually reimbursed. it provides exquisite anatomic detail of the chest and abdomen in patients with esophageal cancer. the only reliable use of ct in the determination of t is the exclusion of t4 tumors, which is suggested by the preservation of fat planes. enlarged lymph nodes are suspicious for metastatic disease but require further study or tissue sampling if nodal metastases will determine treatment. its major ... | 2000 | 10967751 |
| expression of insulin-like growth factor binding proteins (igfbps) before and during the hormone sensitive period of adipose tissue development in the fetal pig. | the present study examined the influence of fetal age and thyroxine (t4) and growth hormone (gh) treatment, on the expression of insulin-like growth factor binding proteins (igfbps) in fetal pigs. on day 70 of gestation fetuses were either hypophysectomized (hypox), hypox and implanted with t4 pellets, or left intact, and were recovered 5, 10, 15 and 20 days following hypox and t4 pellet placement. intact fetuses were also recovered from several dams at 50 days of gestation. in additional dams, ... | 2000 | 10969885 |
| auditory attention processing in 5-year-old children born preterm: evidence from event-related potentials. | the assumption that children born preterm have difficulties in maintaining active attention was tested in passive and active tasks. twenty 5-year-old children born preterm at 26 to 32 weeks gestational age were compared with 20 children born at term, matched for age and iq, using an auditory paradigm. in the passive task participants had to watch a videotape of a cartoon and ignore auditory stimuli. in the active task they had to detect a rare tone (the 'target' tone; 10% of the tones presented) ... | 2000 | 10972420 |
| comparison of two different anesthesia regimens in patients undergoing aortocoronary bypass grafting surgery: sufentanil-midazolam versus remifentanil-propofol. | to compare intraoperative hemodynamics and depth of anesthesia using sufentanil-midazolam (sm) versus remifentanil-propofol (rp) anesthesia. | 2000 | 10972607 |
| [quantitative electroencephalography in obsessive-compulsive disorder: preliminary results]. | the predictive value of quantitative electroencephalography (eegq) was investigated with regard to the pharmacological treatment of 10 non-medicated obsessive-compulsive disorder (ocd) patients diagnosed according to dsm-iv criteria. the following variables were selected: bipolar relative power in alpha band for cz-c3, cz-c4, t3-t5, t4-t6, t3-f7 and t4-f8; bipolar relative power in theta band for cz-c3, cz-c4, t3-t5, t4-t6, t3-f7 and t4-f8; and monopolar relative power in theta band for fp1, fp2 ... | 2000 | 10973109 |
| inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. | genetic and pharmacological studies have defined a role for the melanocortin-4 receptor (mc4r) in the regulation of energy homeostasis. the physiological function of mc3r, a melanocortin receptor expressed at high levels in the hypothalamus, has remained unknown. we evaluated the potential role of mc3r in energy homeostasis by studying mc3r-deficient (mc3r(-/-)) mice and compared the functions of mc3r and mc4r in mice deficient for both genes. the 4-6-month mc3r-/- mice have increased fat mass, ... | 2000 | 10973258 |
| in vivo and in vitro function of groel mutants with impaired allosteric properties. | escherichia coli cells that produce only plasmid-encoded wild-type or mutant groel were generated by bacteriophage p1 transduction. effects of mutations that affect the allosteric properties of groel were characterized in vivo. cells containing only groel(r197a), which has reduced intra-ring positive cooperativity and inter-ring negative cooperativity in atp binding, grow poorly upon a temperature shift from 25 to 42 degrees c. this strain supports the growth of phages t4 and t5 but not phage la ... | 2000 | 10973985 |
| divergent effects of protein kinase c (pkc) inhibitors staurosporine and bisindolylmaleimide i (gf109203x) on bone resorption. | activation of protein kinase c (pkc) has been suggested to play a role in bone resorption. however, phorbol esters, which activate pkc, have been reported to have both stimulatory and inhibitory effects on bone resorption. to study the role of pkc in bone resorption further, we have measured calcium release elicited by bone-resorbing hormones from isolated bones incubated with the pkc inhibitors staurosporine (st) and the more pkc-selective st analog bisindolylmaleimide i (gf109203x; gf). in fet ... | 2000 | 10974200 |
| proliferation parameters in epidermoid carcinomas of the anal canal. | in a prospective study, we assessed the proliferation parameters in primary epidermoid carcinomas of the anal canal, and results were compared with those in cervical carcinomas. | 2000 | 10974385 |
| outcome predictors for 143 patients with superior sulcus tumors treated by multidisciplinary approach at the university of texas m. d. anderson cancer center. | superior sulcus tumors (sst) of the lung are uncommon and constitute approximately 3% of non-small cell lung cancer (nsclc). these tumors cause specific symptoms and signs, and are associated with patterns of failure that differ from those seen for nsclc tumors in other nonapical locations. prognostic factors and most effective treatments are controversial. we conducted a retrospective study at the university of texas m. d. anderson cancer center to identify outcome predictors for patients with ... | 2000 | 10974447 |
| postradiotherapy prostate biopsies: what do they really mean? results for 498 patients. | postradiotherapy (rt) prostate biopsies are prone to problems in interpretation. false negatives due to sampling error, false positives due to delayed tumor regression, and indeterminate biopsies showing radiation effect in residual tumor of uncertain viability are common occurrences. | 2000 | 10974448 |
| three-dimensional small-volume irradiation for residual or recurrent nasopharyngeal carcinoma. | to minimize side effects and to achieve a high local control rate, three-dimensional (3d) small-volume irradiation was used for locally residual or recurrent nasopharyngeal carcinoma. | 2000 | 10974467 |
| external beam radiotherapy dose response characteristics of 1127 men with prostate cancer treated in the psa era. | to characterize the relationship of radiotherapy dose to prostate cancer patient outcome, with an emphasis on the influence of pretreatment prognostic variables. | 2000 | 10974469 |
| [an influence of combined treatment of laryngeal cancer on thyroid gland activity]. | the aim of the research work was to estimate the risk of functional complications arising within thyroid after radiotherapy, when thyroid of patients being ill with carcinoma of head and neck area skin was afflicted with radiation beam as well as to examine whether the circadian rhythmand concentration of hypophysis and thyroid hormones are dependent on combined treatment. the group contained 18 pilot patients treated with combined method, which were examined for concentration and circadian rhyt ... | 2000 | 10974843 |
| [results of surgical treatment in advanced (t3, t4) cancer of the larynx]. | in ent clinic of medical academy in szczecin 962 patients with advanced cancer of the larynx was surgically treated between 1976 to 1995 year. in this group local statement of t3 was observed in 510 cases (53%) and t4 in 452(47%). in the analysis group total laryngectomy was performed in 506 (62.3%) cases, subtotal laryngectomy with phonatory way reconstruction was performed in 234 (24.4%) cases, partial laryngectomy with airway reconstruction in 223 cases (in this number horizontal partial lary ... | 2000 | 10974892 |
| medico-legal implications of hidden thyroid dysfunction: a study of two cases. | in this paper we present two cases in which thyroid disorders were unexpectedly brought to view. the question we ponder is whether hidden thyroid dysfunction may be important in the cause, mechanism and manner of death, or just an incidental discovery during the post-mortem examination. a short literature review has been conducted in order to evaluate previously reported cases of thyroid pathology and sudden death. the significance of post-mortem evaluation of thyroid hormones (t3 and t4) will b ... | 2000 | 10976189 |
| investigation and outcome of neonatal hepatitis in infants with hypopituitarism. | congenital hypopituitarism is a recognized cause of neonatal hepatitis, but the diagnosis may be difficult to establish even if clinically suspected. in order to determine the natural history of this disorder, the outcome of 12 infants with neonatal hepatitis secondary to hypopituitarism is reviewed. the clinical diagnosis of hypopituitarism was established on a combination of features, which include dysmorphism (4 infants), optic nerve hypoplasia (8 infants), micropenis (5 male infants) and rec ... | 2000 | 10976837 |
| a dominant negative creb (camp response element-binding protein) isoform inhibits thyrocyte growth, thyroid-specific gene expression, differentiation, and function. | camp mediates the effects of tsh by regulating thyroid follicular cell proliferation, differentiation, and function. to assess the functional importance of the camp response element binding protein (creb) in thyroid follicular cell regulation in vivo, we targeted the expression of a dominant negative (dn) creb isoform to the thyroid glands of transgenic mice using a tissue-specific promoter. transgenic mice exhibited severe growth retardation and primary hypothyroidism. serum levels of tsh were ... | 2000 | 10976922 |
| adult medulloblastoma: prognostic factors and patterns of relapse. | to determine the patterns of relapse and the prognostic factors for adult medulloblastomas treated in the magnetic resonance imaging era. | 2000 | 10981749 |
| evaluation of a human immunometric assay for the determination of thyroid-stimulating hormone in nonhuman primates. | sera from nine species of clinically healthy nonhuman primates were assayed for t4 and thyroid-stimulating hormone (tsh) using human immunoassays (a fluorescence polarization immunoassay for t4, a microparticle enzyme immunoassay for tsh). the t4 levels ranged from 20 to 132 nmol/l (x +/- sd = 62.8 +/- 24.7 nmol/l). levels of tsh were detected only in western lowland gorillas (gorilla gorilla gorilla) and sumatran orangutans (pongo pygmaeus abelii) (range, 0.4-10.8 miu/l; detectable limit = 0.01 ... | 2000 | 10982149 |
| the paramyxovirus simian virus 5 v protein slows progression of the cell cycle. | infection of cells by many viruses affects the cell division cycle of the host cell to favor viral replication. we examined the ability of the paramyxovirus simian parainfluenza virus 5 (sv5) to affect cell cycle progression, and we found that sv5 slows the rate of proliferation of hela t4 cells. the sv5-infected cells had a delayed transition from g(1) to s phase and prolonged progression through s phase, and some of the infected cells were arrested in g(2) or m phase. the levels of p53 and p21 ... | 2000 | 10982362 |
| survey and summary: holliday junction resolvases and related nucleases: identification of new families, phyletic distribution and evolutionary trajectories. | holliday junction resolvases (hjrs) are key enzymes of dna recombination. a detailed computer analysis of the structural and evolutionary relationships of hjrs and related nucleases suggests that the hjr function has evolved independently from at least four distinct structural folds, namely rnase h, endonuclease, endonuclease vii-colicin e and rusa. the endonuclease fold, whose structural prototypes are the phage lambda exonuclease, the very short patch repair nuclease (vsr) and type ii restrict ... | 2000 | 10982859 |
| euthyroid hyperthyrotropinemia secondary to hyperestrogenemia in a male with congenital adrenal hyperplasia. | a 10-year-old boy with congenital adrenal hyperplasia and associated hyperplastic testicular adrenal rests had high serum concentrations of 17-oh progesterone (17-ohp), estradiol (e2), testosterone (t), and basal and trh-stimulated tsh and prl, but normal thyroid hormones (t3, t4, ft3, ft4) and thyroxine-binding globulin (tbg). upon dexamethasone therapy, steroid hormones returned progressively toward normal as did both prl and tsh; prl declined faster than tsh. serum e2 correlated better with p ... | 2000 | 10983628 |
| thyroid hormones are involved in insulin-like growth factor-i (igf-i) production by stimulating hepatic growth hormone receptor (ghr) gene expression in the chicken. | effect of thyroid status on igf-i production in growing chickens was studied. serum concentrations of gh were not affected by propylthiouracil (ptu) or thyroxine (t4) treatments, whereas serum igf-i levels were significantly decreased in ptu-treated chickens. the lowered serum igf-i levels in the ptu-treated group were completely restored to the control levels by t4 injections. in the liver, the messenger rna (mrna) expressions both for gh receptor (ghr) and igf-i were significantly repressed by ... | 1998 | 10984312 |
| the lectin domain of udp-n-acetyl-d-galactosamine: polypeptide n-acetylgalactosaminyltransferase-t4 directs its glycopeptide specificities. | the initiation step of mucin-type o-glycosylation is controlled by a large family of homologous udp-galnac:polypeptide n-acetylgalactosaminyltransferases (galnac-transferases). differences in kinetic properties, substrate specificities, and expression patterns of these isoenzymes provide for differential regulation of o-glycan attachment sites and density. recently, it has emerged that some galnac-transferase isoforms in vitro selectively function with partially galnac o-glycosylated acceptor pe ... | 2000 | 10984485 |
| prospective pulmonary function evaluation following open thoracotomy for anterior spinal fusion in adolescent idiopathic scoliosis. | prospective study. | 2000 | 10984783 |
| [autonomy of the thyroid gland: is there an "organ hyperthyroidism" of "euthyroid" patients?]. | classic thyrotoxicosis is defined as the clinical syndrome of hypermetabolism that results when concentrations of serum free thyroxine (ft4), serum free triiodothyronine (ft3), or both are increased and serum level of tsh is suppressed. the term of subclinical thyrotoxicosis refers to a usually asymptomatic state associated with normal serum ft4 and ft3 and low serum tsh concentrations. | 2000 | 10985062 |
| [laryngo-hypopharyngo-esophagectomy in advanced hypopharyngeal carcinoma. is radical surgery intervention still justified today?]. | minimal invasive laser surgery with preservation of the organs is well established in the treatment of hypopharynx carcinoma. in cases of advanced tumors of the hypopharynx, which can not be managed by laser surgery, the combined radio-chemo therapy becomes the treatment of choice because of the low morbidity and the comparable results. the indication for an operative procedure, which means loss of larynx and oesophagus, is seen more and more restrictively. from 1993 to 1997 101 patients with ad ... | 2000 | 10986749 |
| [the definitive radiochemotherapy in patients with t4 and/or m1 (lymph node) squamous-cell carcinoma of the esophagus]. | | 2000 | 10987025 |
| studies on thyroid function in rats subjected to repeated oral administration with kojic acid. | to elucidate the effects of kojic acid on thyroid function, the compound was given orally to male rats for 4 weeks at 0, 4, 15, 62.5, 250 and 1,000 mg/kg. in 1,000 mg/kg treatment of kojic acid, the rats showed a slight decrease in motility, inhibition of body weight gain, and a decrease in food consumption. an increase in thyroid weight and a morphological change, i.e., hypertrophy of epithelial cells of the thyroid gland follicles, were observed after 1 week of administration. in addition, the ... | 2000 | 10987123 |
| effect of thyroxine on calcium distribution in rat thymocytes in vitro. | chlorotetracycline (ctc) was used as a fluorescent ca2+-sensitive probe to study the redistribution of intracellular membrane-bound ca2+ in thyroxine (t4)-treated rat thymocytes. incubation of thymocytes in the ca2+-supplemented medium in the presence of 1-100 nm t4 for 30 min resulted in a twofold increase in the amount of egta-accessible plasma membrane-bound ca2+ as compared to that in the ca2+-free medium. the induced decrease in ctc fluorescence was more pronounced with the occurrence of re ... | 2000 | 10987386 |
| partial complementation of the dna repair defects in cells from xeroderma pigmentosum groups a, c, d and f but not g by the denv gene from bacteriophage t4. | endonuclease v (denv) from bacteriophage t4 was examined for its ability to complement the dna repair defect in xeroderma pigmentosum (xp) cells from complementation groups a, c, d, f and g. the denv gene was introduced into sv40-transformed normal and xp cells using a retroviral vector. expression of denv resulted in partial correction of uv sensitivity and increased host cell reactivation (hcr) of a uv-damaged reporter gene for xp cells from groups a, c and d, but not those from group g. expre ... | 2000 | 10989608 |
| [contribution of the renin-angiotensin system to blood pressure variability in hyperthyroid rats]. | to produce a chronical thyrotoxicosis model in rat, and to evaluate, using spectral analysis, the involvement of the renin-angiotensin system (ras) in short-term variability of blood pressure (bp) in experimental hyperthyroidism. | 2000 | 10989728 |
| optimal dose of intrathecal clonidine added to sufentanil plus bupivacaine for labour analgesia. | the combination of intrathecal (it) 5 microg sufentanil plus 1.25 mg bupivacaine is useful for inducing labour analgesia, albeit of short duration and slow onset. as a supplementation to this regimen, the effect of it clonidine on the duration of analgesic action was investigated. | 2000 | 10989857 |
| anomalous x-ray yields under surface wave resonance during reflection high energy electron diffraction and adatom site determination | in l x-ray emissions from a si(111)-sqrt[3]xsqrt[3]-in surface induced by electron beam irradiation were measured as functions of the incident glancing angle. under surface wave resonance conditions, anomalous x-ray intensities were clearly observed. using dynamical calculations, these intensities are well explained as changes in density of the electron wave field at adatom positions. from these intensities, the adatom site was analyzed, and it was found that the t4 model is better than the h3 m ... | 2000 | 10990693 |
| [malignant maxillary tumors involving the pterygo-maxillary and infratemporal fossae: a series of 200 cases]. | at the cranio-maxillo-facial surgery unit of the istituto nazionale per lo studio e la cura dei tumori in milan, italy between 1987 and 1999 200 anterior cranio-facial resections were performed on malignant ethmoid tumors involving the anterior cranial base and extending to the nasal fossae and, at times to the orbit and maxillary and sphenoid sinuses. in the second portion of this case study the authors simplified their surgical technique. the frontal craniotomy was made rectangular and low, pe ... | 2000 | 10992601 |
| [malignant maxillary tumors involving the pterygo-maxillary and infratemporal fossae: a series of 65 patients and a comparison of the 1997 and 1977 uicc-ajcc staging systems]. | the prognosis for maxillary malignancies with posterior extension to the pterygo-maxillary and infratemporal fossae is worse than for those with anterior-inferior extrinsication. maxillectomy using only an anterior approach does not enable enblock, radical resection of such tumors. many different approaches to the infratemporal fossae have been described in the literature. the authors use a double infratemporal and transfacial approach. between 1990 and 1998 this approach was used on 65 patients ... | 2000 | 10992602 |
| comparison of succinylcholine with two doses of rocuronium using a new method of monitoring neuromuscular block at the laryngeal muscles by surface laryngeal electromyography. | we compared the onset of neuromuscular block with succinylcholine (1 mg kg-1) and two doses of rocuronium (0.6 and 0.9 mg kg-1) at the adductor pollicis muscle using electromyography (emg) and acceleromyography (amg), and at the adductor laryngeal muscles with a new electromyographic method using a disposable surface electrode attached to the cuff of a tracheal tube. at the larynx, the mean (+/- sd) time to 90% block and the onset time of succinylcholine (38 +/- 15 and 47 +/- 19 s, respectively) ... | 2000 | 10992834 |
| rapacuronium recovery characteristics and infusion requirements during inhalation versus propofol-based anaesthesia. | we examined the effect of four maintenance anaesthetics on the neuromuscular blocking activity and spontaneous recovery characteristics after a short-term infusion of rapacuronium. eighty asa i-iii adult patients undergoing elective surgery were studied at four centres. anaesthesia was induced with propofol 1.5-2.5 mg kg-1 and fentanyl 1-2 micrograms kg-1, followed by a bolus of rapacuronium 1.5 mg kg-1. the patients were randomized to receive either desflurane (2-4% end-tidal, et), sevoflurane ... | 2000 | 10992842 |
| evaluation of thyroid function in dogs suffering from recurrent flank alopecia. | thyroid function was assessed in euthyroid dogs (n = 20), dogs suffering from canine recurrent flank alopecia (crfa, n = 18), and hypothyroid dogs (n = 21). blood samples obtained from all dogs in each group were assayed for total thyroxine (tt4), thyrotropin (tsh), and thyroglobulin autoantibody (tgaa) serum concentrations. total t4 and tsh serum concentrations were significantly decreased and increased, respectively, in the hypothyroid group compared with the other 2 groups. no significant dif ... | 2000 | 10992988 |
| synthesis of 4-thiouridine, 6-thioinosine, and 6-thioguanosine 3',5'-o-bisphosphates as donor molecules for rna ligation and their application to the synthesis of photoactivatable tmg-capped u1 snrna fragments. | 4-thiouridine, 6-thioguanosine, and 6-thioinosine 3',5'-bisphosphates (9, 20, and 28) were synthesized in good yields by considerably improved methods. in the former two compounds, uridine and 2-n-phenylacetylguanosine were converted via transient o-trimethylsilylation to the corresponding 4- and 6-o-benzenesulfonyl intermediates (2 and 13), which, in turn, were allowed to react with 2-cyanoethanethiol in the presence of n-methylpyrrolidine to give 4-thiouridine (3) and 2-n-phenylacetyl-6-thiogu ... | 2000 | 10993333 |
| five-day triple therapy in helicobacter pylori-positive duodenal ulcer: an eighteen-month follow-up. | the aim of this study was to compare the efficacy of two different 5-day proton pump inhibitor (ppi)-based triple therapies for helicobacter pylori (hp)-positive duodenal ulcers (dus). eighty-four patients received pantoprazole (pan) 80 mg o.d. (once daily) for 1 week; 88 patients received omeprazole (ome) 40 mg o.d. for 1 week. patients of both groups received clarithromycin (cla) 500 mg b.i.d. (twice daily) and amoxicillin (amo) 1 g b.i.d. for 5 days. all of them were clinically and endoscopic ... | 2000 | 10993428 |
| size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage t4 lysozyme. | to investigate the relative importance of size and polarizability in ligand binding within proteins, we have determined the crystal structures of pseudo wild-type and cavity-containing mutant phage t4 lysozymes in the presence of argon, krypton, and xenon. these proteins provide a representative sample of predominantly apolar cavities of varying size and shape. even though the volumes of these cavities range up to the equivalent of five xenon atoms, the noble gases bind preferentially at highly ... | 2000 | 10993735 |
| modeling protein-small molecule interactions: structure and thermodynamics of noble gases binding in a cavity in mutant phage t4 lysozyme l99a. | the complexes of phage t4 lysozyme l99a with noble gases have been studied by molecular dynamics simulation. in a long simulation of the complex with one xe atom, the structure was found to undergo global conformation change involving a reversible opening and closing of the entrance to the substrate-binding site, during which the conformations of the n and c-terminal domains varied little. the distributions of xe positions sampled in dynamics simulations were refined in terms of anisotropic gaus ... | 2000 | 10993736 |
| [inverted papilloma of the nose and paranasal sinuses. long-term outcome of endoscopic endonasal resection]. | there is still some skepticism about endoscopic endonasal resection of inverted papillomas. we conducted a long-term retrospective study and examined 104 patients (82 male, 22 female) with inverted papilloma who were operated at the ent-department of the university of erlangen between 1974 and 1997. the endoscopic approach was chosen in each case, either alone or in combination with external approaches. in 64.4% (67 cases), tumors of all t-classes were resected by endoscopic approach alone (t1:1 ... | 2000 | 10994167 |
| [gene riib from bacteriophage t4 in genetic recombination]. | the effect of the riib gene on genetic recombination in bacteriophage t4 was studied. relationships between recombination frequency and the physical distance were determined in three series of isomarker two-factor crosses between rii mutants. in the first series of intergenic crosses (riia x riib), the rii gene function was restored owing to complementation. in the second series of crosses, identical to the first one, the riib gene function was suppressed, because the riia parent carried an addi ... | 2000 | 10994495 |
| direct effects of propylthiouracil on testosterone production in monkeys. | propylthiouracil (ptu) is an anti-thyroid drug. however, the direct effects of ptu on the endocrine functions of non-thyroid glands are unclear. in the present study, we examined the acute effects of ptu on testosterone secretion in monkeys. male monkeys were infused intravenously with ptu for 30 min. blood samples were collected at several time intervals. monkey testicular interstitial cells were cultured with ptu, human chorionic gonadotropin (hcg), or forskolin, at 34 degrees c for 1 h. in an ... | 2000 | 10994694 |
| [prevalence of thyroid disorders in patients diagnosed with depression]. | to determine the prevalence of thyroid disorders in patients diagnosed with depression. | 2000 | 10996952 |
| a study of peristomal recurrence. | this is a retrospective and a prospective study of 435 laryngectomized patients at the department of otolaryngology, cairo university, between 1987 and 1997. the authors analyze the data of 26 patients who returned with peristomal recurrence. a statistical analysis was performed to determine the correlation between peristomal recurrence, and the site of the primary tumor, its stage, the presence of nodal metastases and the performance of an emergency tracheostomy more than 48 hours before surger ... | 2000 | 10997072 |
| thyroid hormone metabolism in obesity. | serum thyroid hormone concentrations and their metabolic fate are within the normal range limits in obese subjects. also serum tsh concentrations and its response to trh are normal, suggesting that tissue availability of thyroid hormones is normally preserved in these subjects. in contrast, during caloric restriction serum t3 concentrations decrease as a consequence of its reduced production rate from peripheral deiodination of t4. opposite, serum rt3 concentrations markedly increase as a result ... | 2000 | 10997624 |
| thyroid and sympathetic influences on plasma leptin in hypothyroidism and hyperthyroidism. | to determine the dependence of plasma leptin concentrations upon circulating noradrenaline (na) and thyroid hormones (th) in humans. | 2000 | 10997647 |
| [graves-basedow's disease in childhood and adolescence: clinical and biologic features in 49 patients]. | graves' disease is rare in childhood and adolescence. | 2000 | 10998396 |
| predictor of outcome of hyperthyroidism due to graves disease: serum triiodothyronine/thyroxine ratio. | there is a proportionally greater increase in the serum t3 than serum t4 concentration in patients with hyperthyroidism due to grave's disease which results in an elevation of serum t3 to t4 ratio. the study was undertaken to investigate the alteration of serum t3 to t4 ratio in relation to the outcome of antithyroid drug therapy. 98 patients of hyperthyroid grave's disease were studied and 78 patients had t3 to t4 ratio greater than 20 ng/microgram before therapy (normal range 14-20; mean 16.0) ... | 1996 | 10999059 |
| sub-biochemical hypothyroidism: an exaggerated thyroid stimulating hormone response to thyrotrophin releasing hormone. | the availability of sensitive and specific assays for evaluation of the thyroid axis has allowed definition of thyroid disorders at subclinical stage. this has almost obviated the use of thyrothrophin releasing hormone (trh) study. we describe here a group of patients with minimal signs of hypothyroidism having normal thyroid function tests (t3, t4, thyroid stimulating hormone (tsh)) and have shown exaggerated tsh response to trh. | 1999 | 10999119 |
| clinical review 115: effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature. | the objective of our study was to estimate the expected change in serum lipoprotein concentrations after treatment with t4 in patients with mild thyroid failure (i.e. subclinical hypothyroidism). our data sources included medline, between january 1966 and may 1999, and review of references from relevant articles. there were 1,786 published studies identified, 461 abstracts reviewed, 74 articles retrieved, 24 articles evaluated against predetermined entry criteria, and 13 studies systematically r ... | 2000 | 10999775 |
| effects of metyrapone administration on thyrotropin secretion in healthy subjects--a clinical research center study. | although pharmacological doses of glucocorticoids suppress tsh secretion, less is known regarding the effects of physiological variations in cortisol levels on tsh. to study this issue, 12 healthy subjects each underwent 2 studies, in random order: 1) each subject received an infusion of saline for 48 h; and 2) each subject received an infusion of saline and oral administration of metyrapone (500 mg every 4 h) for 48 h. cortisol and tsh levels were measured every 15 min during the final 24 h of ... | 2000 | 10999784 |
| thyroid function and intellectual development of infants nursed by mothers taking methimazole. | for many years, breast-feeding was forbidden if antithyroid drugs were being used. recently, limited studies have shown the relative safety of propylthiouracil and methimazole (mmi). it is not known whether mmi therapy of lactating mothers for 1 yr is safe for breast-fed infants and does not cause alterations in thyroid function and intellectual development. between 1988 and 1998, 139 thyrotoxic lactating mothers and their infants were studied. fifty-one thyrotoxic lactating mothers were treated ... | 2000 | 10999814 |
| thyroid hormone levels in cord blood of infants with acidemia at birth. | to study the funic thyroid hormone levels in cases were fetal distress during labor resulted in acidemia at birth. | 2000 | 11000504 |
| identification of essential amino acids in the bacterial alpha -mannosyltransferase acea. | the alpha-mannosyltransferase acea from acetobacter xylinum belongs to the cazy family 4 of retaining glycosyltransferases. we have identified a series of either highly conserved or invariant residues that are found in all family 4 enzymes as well as other retaining glycosyltransferases. these residues included glu-287 and glu-295, which comprise an ex(7)e motif and have been proposed to be involved in catalysis. alanine replacements of each conserved residue were constructed by site-directed mu ... | 2000 | 11001941 |