| nonebv-related b-cell lymphoma in a renal transplant patient responding to acyclovir and reduction in immunosuppression. | a case of polyclonal b-cell pharyngeal lymphoma in a renal transplant patient is reported. no evidence of epstein-barr virus involvement was detected, but the lymphoma underwent complete remission with acyclovir and reduction in immunosuppression. | 1992 | 1570259 |
| diagnosis and management of parotitis. | of all the salivary glands, the parotid gland is most commonly affected by an inflammatory process. infections of the parotid gland range from acute to severe. assessment of the disease process should differentiate local primary parotid infection from systemic infection when this gland is also involved as part of a generalized inflammatory condition. viral parotitis can be caused by paramyxovirus (mumps), epstein-barr virus, coxsackievirus, and influenza a and parainfluenza viruses. acute suppur ... | 1992 | 1571113 |
| malignant lymphoma associated with human aids and with siv-induced immunodeficiency in macaques. | malignant lymphomas associated with human (hiv) and simian (siv) immunodeficiency virus infections are reviewed and compared. recent observation of a high frequency of lymphomas in a series of cynomolgus macaques, highly immunodeficient after infection with sivsm(smm3) are described. in addition to the increased frequency in human and monkey aids, siv and hiv lymphomas share several important features. clinically and by histology they present as aggressive high-grade malignant tumors with a pred ... | 1992 | 1571194 |
| a human monoclonal autoantibody to a nucleolar structure. | peripheral blood lymphocytes from a scleroderma patient (cdc) were isolated, transformed with epstein-barr virus and fused to the heteromyeloma shm-d33. supernatants from cultures were screened for autoantibody production against nucleoprotamine by elisa. positive wells were cloned by limiting dilution. after cloning, supernatants from two wells were positive for the nucleoprotamine assay. one named cdc-1 has been studied in our laboratory. cdc-1 recognized a nucleolar antigen by indirect immuno ... | 1992 | 1572098 |
| t cells with specificity for idiotypic determinants on human monoclonal autoantibodies in myasthenia gravis. | the activation of t cells from 46 patients with myasthenia gravis and 28 healthy individuals by two human monoclonal autoantibodies was studied. b-cell clones were produced by transformation of peripheral lymphocytes from a patient using epstein-barr virus and subsequent cloning. two myasthenia-specific autoantibodies, one anti-receptor-antibody and one antiidiotypic antibody, both carrying separate recurrent idiotopes, were used in this study. single activated t cells were identified by their s ... | 1992 | 1574640 |
| [infectious mononucleosis in childhood]. | we present 42 cases of infectious mononucleosis caused by the epstein-barr virus in children. patients were divided into two groups: those less than 4 years old and those 4 to 16 years of age. splenomegaly was more frequent in young patients. treatment with amoxicillin was associated with cutaneous rash. heterophil antibodies were more frequent in patients older than four years of age. in 93% of the cases anticapside antibodies of igm class were present. complications were rarely encountered. pn ... | 1992 | 1580434 |
| cellular and molecular genetic features of myeloma and related disorders. | the last decade has seen major advances in the acquisition of knowledge concerning both the cellular and molecular genetics of multiple myeloma. although discrete and specific changes associated with the plasma cell disorders have yet to be identified, a pattern is emerging that one can associate with the plasma cell disorders. this pattern includes the frequent involvement of chromosomes 1 and 14, and in particular presence of the 14q+ abnormality. but in addition there are typically many other ... | 1992 | 1582985 |
| [hemolytic anemia due to cold-reacting antibodies: association with human immunodeficiency virus infection and non-hodgkin's lymphoma]. | hemolytic disease by cold-reacting antibodies is a rare form of hemolytic anemia. in most cases a subjacent cause is found. this disease is generally related with reactive lymphoproliferative processes (infections by the epstein-barr virus and cytomegalovirus) or uncontrolled lymphoproliferative disorders (lymphomas, waldenström disease, chronic lymphatic leukemia). the presence of high titers of cryoagglutinins have recently been described in patients infected by the human immunodeficiency viru ... | 1992 | 1583950 |
| loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cdna transcription of insulin-like growth factor i. | malignant glioma is the most common brain tumor. the molecular basis of glioma tumorigenicity has not been defined. cultured glioma cells accumulate high levels of insulin-like growth factor i (igf-i) transcripts. we asked whether igf-i expression is coupled to tumorigenicity, using a combined in vivo/in vitro system employing antisense rna for igf-i. an antisense igf-i expression construct in an expression vector that incorporates epstein-barr virus replicative signals and the znso4-inducible m ... | 1992 | 1594587 |
| posttransplant lymphoproliferative disorder presenting as an isolated skin lesion. | a case of posttransplant lymphoproliferative disorder (ptld) presenting as an isolated skin lesion is reported. an initial superficial biopsy of the lesion was diagnosed as squamous cell carcinoma. after pathologic review of the biopsy and staining for immunoglobulins and epstein-barr virus (ebv) dna, the correct diagnosis of ptld was made. the patient had no systemic manifestations of lymphoma and the skin lesion was successfully treated with excision. isolated skin lesions should be included a ... | 1992 | 1595711 |
| biological markers associated with prolonged survival in african children maternally infected by the human immunodeficiency virus type 1. | sixteen children over the age of 5 years (group 1) have been identified out of 537 children infected by human immunodeficiency virus and born to hiv-infected mothers, in kigali, rwanda. they were followed up for 2 years and compared with 16 younger aids patients (group 2) and with 16 age- and gender-matched hiv-1 seronegative children (group 3). fourteen group 1 subjects had anti-hiv-1 igm which persisted during the entire study period, in 11 cases directed to hiv-1 envelope proteins. in vitro, ... | 1992 | 1599753 |
| affinity of ssb/la nuclear antigen to small nuclear ribonucleic acids. | anti-ssb/la antibody is one kind of antinuclear antibody and is found predominantly in patients with sjögren's syndrome and systemic lupus erythematosus. ssb/la antigen is present in the nucleus as ribonucleoprotein in particle form and is composed of peptide and rnas. ssb/la antigen can be partially purified through several sequential procedures including salt fractionation and ion exchange chromatography. ssb/la antigen is capable of binding to 4 rnas from uninfected kb cells and 6 rnas from e ... | 1992 | 1599901 |
| tissue-specific and allelic expression of the complement regulator cd46 is controlled by alternative splicing. | cd46 (membrane cofactor protein) is a human cell surface glycoprotein with cofactor activity for factor i-mediated cleavage of complement components c3b and c4b. the cd46 protein from normal lymphocytes resolves on sodium dodecyl sulfate-polyacrylamide gel electrophoresis as two major bands of 66 and 56 kda. cd46 cdna encodes four extracellular short consensus repeat domains, a ser/thr/pro (stp)-rich region, a transmembrane region and a cytoplasmic tail. we now show that exquisite control of mrn ... | 1992 | 1601037 |
| establishment and characterization of macaca fascicularis lymphoblastoid cell lines. | a panel of cynomolgus macaque lymphoblastoid cell lines (lcl) was established by transforming peripheral blood mononuclear cells (pbmc) with herpesvirus papio (hvp), and selected lines were examined by flow cytometry. results indicate that hvp-transformed macaque lcl are phenotypically heterogeneous and resemble human epstein-barr virus (ebv)-transformed lcl in the abundant expression of major histocompatibility complex (mhc) class i and class ii molecules. at least some lines are of b cell orig ... | 1992 | 1602455 |
| tumours of the nose and maxillary sinus. ten year survey from kenya. | between 1976-1985, 127 cases of malignant tumours of the nose and maxillary sinus were seen at the department of human pathology, kenyatta national hospital, nairobi, kenya. cancer of the nose and maxillary sinus was a common diagnosis accounting for 0.8 per cent of all malignancies. despite this, the incidence was low probably because the rural kenyans have difficulty in gaining access to the oncology facilities in nairobi. incidence rates standardized to world population per 100,000 persons-ye ... | 1992 | 1613347 |
| measles virus transmembrane fusion protein synthesized de novo or presented in immunostimulating complexes is endogenously processed for hla class i- and class ii-restricted cytotoxic t cell recognition. | the routes used by antigen-presenting cells (apc) to convert the transmembrane fusion glycoprotein (f) of measles virus (mv) to hla class i and class ii presentable peptides have been examined, using cloned cytotoxic t lymphocytes in functional assays. presentation by epstein-barr virus-transformed b lymphoblastoid cell lines was achieved using live virus, ultraviolet light-inactivated virus, and purified mv-f delivered either as such or incorporated in immunostimulating complexes (mv-f-iscom). ... | 1992 | 1613454 |
| fever of unknown origin. | fuo is an uncommon problem in pediatric patients if one uses a strict definition of at least 2 weeks of fever. perhaps the best definition, as suggested by lorin and feigin, is more than 1 week of fever and a negative initial evaluation, including examination and preliminary laboratory results. most patients, especially younger ones, will spontaneously improve or have common disorders, usually respiratory-related infections. most patients will have uncommon manifestations of more commonly recogn ... | 1992 | 1616682 |
| aids lymphomas. | chronically immunosuppressed individuals are susceptible to lymphoreticular tumors. up to 15% of patients with congenital deficiencies such as ataxia=telangiectasia may develop malignancies, mainly high-grade b cell non=hodgkin's lymphomas (nhls). aids lymphomas are comprised of nhls including burkitt's lymphoma (bl) and primary cerebral lymphomas (pcls). almost 3% of all aids patients (2824 of 97,258 cases) developed nhl. epstein-barr virus (ebv) as a co-factor in aids lymphomagenesis has b ... | 1992 | 1616963 |
| documentation of burkitt lymphoma with t(8;14) (q24;q32) in x-linked lymphoproliferative disease. | acquired hypogammaglobulinemia or agammaglobulinemia, aplastic anemia, chronic or fatal infectious mononucleosis (im), virus-associated hemophagocytic syndrome, and a variety of b-cell malignant lymphomas (ml) develop in boys with x-linked lymphoproliferative disease (xlp) after infection by the epstein-barr virus (ebv). they have an inherited immunodeficiency to ebv. approximately 80% of the patients die during childhood and 100% by the age of 40. the ml occurring in patients with xlp are diffe ... | 1992 | 1623484 |
| specificity, t cell receptor diversity and activation requirements of cd4+ and cd8+ clones derived from human melanoma-infiltrating lymphocytes. | to try to understand the functional significance of human melanoma-infiltrating lymphocytes (til), a clonal analysis of the specificity, t cell receptor (tcr) diversity and activation requirements of these lymphocytes isolated from four different tumors was carried out. supporting the presence of in vivo primed tumor-specific t lymphocytes in these four tumors, a high frequency of the cd8+ and cd4+ clones, obtained from the til cultured for a few days with recombinant interleukin (ril)-2 and aut ... | 1992 | 1623924 |
| rapid development of an immunoblastic lymphoma and death in children following cadaveric renal transplantation. | we report on three children who underwent cadaveric renal transplantation and subsequently developed an immunoblastic lymphoma, leading to death in two patients. the development of the lymphoma occurred following a multi-drug immunosuppression regimen ending with monoclonal antilymphocyte (okt3) treatment for biopsy-proven cellular and vascular acute rejection. these patients represent three of 11 children who received okt3 treatment for rejection in the last 18 months at this institution. follo ... | 1992 | 1625136 |
| t lymphocyte anergy during acute infectious mononucleosis is restricted to the clonotypic receptor activation pathway. | the transient t cell anergy associated with acute infectious mononucleosis (im) caused by the epstein-barr virus has been analysed in a sample of 14 im children. peripheral blood mononuclear cells (pbmc) obtained from im patients showed a significant specific impairment in their proliferative response to both phytohaemagglutinin (pha; p less than 0.05) and to an anti-cd3 moab (p less than 0.001), although both responses reached normal control levels by addition of a submitogenic dose of either p ... | 1992 | 1628427 |
| intraocular and central nervous system lymphoma in a cardiac transplant recipient. | although b-cell lymphomas are the most frequent cancers that evolve in transplant patients, histopathologic verification of intraocular lymphoma as a result of cyclosporine immunosuppression has not been previously recognized. | 1992 | 1630788 |
| hla molecules in autoimmune diseases. | the association of certain autoimmune diseases with hla molecules is being refined through the use of sequence-specific oligonucleotide probes and amino acid sequencing, together with continuing elucidation of the functional features of hla molecules derived from the milestone description by bjorkman of the hla molecular structure. the association of insulin-dependent diabetes mellitus and hla began with weak associations of class i antigens (b8 and b15) and progressed to class ii antigens (dr3 ... | 1992 | 1633634 |
| myc rearrangements in histologically progressed follicular lymphomas. | histologic transformation of low-grade follicular lymphoma to an aggressive-grade lymphoma occurs in 60% to 80% of patients during their clinical course. the events that drive the transformation process are poorly understood. deregulation of the myc gene has been implicated in a small number of cases. this observation led us to examine the molecular organization of the myc oncogene in 38 cases of histologically transformed lymphomas that arose from follicular lymphomas, and in 18 of the initial ... | 1992 | 1638027 |
| the pattern of p53 mutations in burkitt's lymphoma differs from that of solid tumors. | available evidence suggests that, among hematological malignancies, p53 is most often mutated in burkitt's lymphoma (bl). however, much of the published data is based on cell lines. we have, therefore, analyzed bl biopsies to determine more accurately the frequency and pattern of p53 mutations in primary tumors and to determine whether there are differences among the various subtypes of bl. among 27 bl biopsies from south africa, we have observed mutations in the p53 gene (exons 5 through 8) in ... | 1992 | 1638540 |
| allele-specific expression of the cytoplasmic exon of hla-dqb1 gene. | the beta chain of the hla-dq molecule is shorter by eight amino acid residues than other major histocompatibility complex class ii beta chains due to elimination of the fifth exon coding for part of the cytoplasmic domain. this elimination is caused by one base substitution in the splice acceptor site of the exon. we found that two hla-dqb1 alleles, dqb1*0503 and dqb1*0601, did not have this substitution, and the exon was utilized in these two alleles. however, two forms of hla-dqb mrna, with or ... | 1992 | 1644449 |
| decreased antibody reactivity to epstein-barr virus capsid antigen in type 1 (insulin-dependent) diabetes mellitus. | in this study, antibody levels to epstein-barr virus (ebv) capsid antigen (vca) and ebv early antigens (ea) were analysed by enzyme immunoassay in 54 newly diagnosed type 1 diabetic children and in matched controls. the patients had significantly lower ebv vca igg-class antibody levels (p less than 0.02). this was true particularly in young patients and in boys (p less than 0.005). vca iga-class antibody levels were also decreased in young patients (p less than 0.02). vca igm-class antibodies we ... | 1991 | 1645169 |
| ocular-systemic interrelationships in acquired immunodeficiency syndrome. | we analysed the correlation between ophthalmic and systemic findings in 125 subjects with aids and 50 subjects with aids-related complex (arc). positive eye findings were defined as the presence of cotton-wool spots (cws) or cytomegalovirus (cmv) retinitis. the presence of positive eye findings was significantly more frequent in aids than in arc (p = 0.0001). both lowest haematocrit and lowest t-helper cell count were significantly lower in aids than in arc, and also lower in subjects with posit ... | 1991 | 1645204 |
| excretion of the epstein-barr virus from the genital tract of men. | epstein-barr virus (ebv) dna was detected by polymerase chain reaction in urethral discharges from 10 (48%) of 21 men attending a clinic for sexually transmitted diseases. five of the 10 subjects were concurrently excreting virus from their oropharynx. these findings indicate that ebv is shed from more than one mucosal site in seropositive adult males. involvement of the genital tract raises the possibility of sexual transmission as well as ebv-induced genital tract pathology. | 1991 | 1645383 |
| an update of the classification and diagnostic criteria of oral lesions in hiv infection. eec-clearinghouse on oral problems related to hiv infection and who collaborating centre on oral manifestations of the human immunodeficiency virus. | | 1991 | 1645406 |
| evidence for a functional glucocorticoid responsive element in the epstein-barr virus genome. | glucocorticoids induce the expression of epstein-barr virus early antigens in latently infected daudi cells. by sequence analysis, we found that fragment c of the bamhi digested epstein-barr virus b95-8 genome contains a region with a large degree of homology to the glucocorticoid responsive element of known glucocorticoid-regulated genes. by transfection experiments in daudi and hela cells, different lengths of this region, cloned in front of the bacterial chloramphenicol acetyl transferase lin ... | 1991 | 1645455 |
| [cytomegalovirus antibodies in infectious mononucleosis--case history]. | a case of infectious mononucleosis was presented, with transient presence of antibodies toward cytomegalovirus. presence of the antibodies was interpreted as resulting from polyclonal b cell activation by epstein-barr virus. | 1991 | 1645470 |
| [what is your diagnosis? hiv-infection (cdc iv c2) with oral hairy leukoplakia]. | | 1991 | 1645475 |
| oral hairy leukoplakia in a hiv-negative renal graft recipient. | oral hairy leukoplakia (ohl) is seen almost exclusively in patients infected with hiv. a case is reported of ohl occurring in a patient who was seronegative for hiv and who had a renal graft. this occurred following an increase in his treatment with immunosuppressive drugs. | 1991 | 1645582 |
| inhibition of epstein-barr virus infection in vitro and in vivo by soluble cr2 (cd21) containing two short consensus repeats. | the extracellular domain of cr2, the epstein-barr virus (ebv)/c3d receptor of b lymphocytes, contains 15 or 16 tandemly arranged short consensus repeat elements (scr). recombinant cr2 proteins containing scr 1 and 2 fused to staphylococcus aureus protein a (pa-cr2) and to murine complement factor h scr 20 (cr2fh) were expressed in escherichia coli and in insect cells, respectively. these recombinant cr2 molecules retained functional activity as indicated by their ability to bind to c3dg in an en ... | 1991 | 1645784 |
| negative regulation of the bzlf1 promoter of epstein-barr virus. | the epstein-barr virus bzlf1 gene product (zebra) is a transcriptional activator whose expression in latently infected b cells is sufficient to induce the viral lytic cycle. since there is no transcription of bzlf1 during latency, we carried out experiments to determine whether cis-acting negative elements in the bzlf1 promoter contribute to the lack of expression during this phase of the virus cycle. a series of deletion plasmids encompassing positions -551 to +14 of the bzlf1 promoter region w ... | 1991 | 1645787 |
| biochemical characterization of epstein-barr virus nuclear antigen 2a. | the epstein-barr virus nuclear antigen 2a (ebna-2a) was immunoprecipitated from latently epstein-barr virus-infected lymphocytes with a polyclonal serum raised against the ebna-2a c terminus. the nucleus contained three subfractions of ebna-2a which could be distinguished by their resistance to salt extraction: (i) a nucleoplasmatic fraction that was solubilized at 50 mm nacl, (ii) a chromatin-associated fraction extractable at 1.5 m nacl, and (iii) a nuclear matrix-associated fraction solubiliz ... | 1991 | 1645792 |
| the prototypical epstein-barr virus-transformed lymphoblastoid cell line ib4 is an unusual variant containing integrated but no episomal viral dna. | ib4 is a prototype, latently epstein-barr virus (ebv)-infected, lymphoblastoid cell line. we show here that ib4 contains only integrated ebv genomes. episomal ebv dna is not detected by gardella gel analysis or in situ hybridization. restriction enzyme mapping indicates that the ebv genomes first circularized and then integrated into and deleted part of the bamhi c fragment. ib4 is therefore the only lymphoblastoid cell line described to date that lacks episomal ebv and has integrated ebv genome ... | 1991 | 1645805 |
| antibody response against the epstein-barr virus-coded nuclear antigen2 (ebna2) in nasopharyngeal carcinoma. | specific antibody responses against the epstein-barr virus-coded nuclear antigen2 (ebna2) were evaluated. thirty-five sera from pretreatment patients of nasopharyngeal carcinoma (npc) and 12 from healthy adults were tested. although the anti-ebna2 response did not show any correlation with t stage, overall stage, or histopathology, it showed a correlation with the n stage of the disease. in a serological follow-up study, 17 (85%) of 20 patients showed a correlation on the change of antibody leve ... | 1991 | 1645832 |
| domains of the epstein-barr virus (ebv) transcription factor r required for dimerization, dna binding and activation. | in cells latently infected with ebv, the switch from latency to a productive infection is linked to the expression of two transcriptional activators, the upstream element factor eb1 and the enhancer factor r. r activates by interacting directly with specific dna sequences called rres (r responsive elements). each binding site covers about 18 bp, where r simultaneously contacts two core sequences separated by 5 to 7 bp (1). here we show that r binds in vitro as a homodimer to an rre, and that sta ... | 1991 | 1645863 |
| the immunoregulatory effects of merocyanine 540 on in vitro human t- and b-lymphocyte functions. | merocyanine 540 (mc 540) is a photoactive dye used to purge bone marrow of tumor cells in autologous bone marrow transplantation. the effects of mc 540 on the lymphoid components in the marrow are unknown. this study evaluates the treatment of lymphocytes by mc 540 (15 micrograms/ml) and light (70 w/m2) on: (1) phytohemagglutinin and con a-induced proliferation; (2) allogeneic mixed lymphocyte cultures (mlc); (3) the regulation of ig synthesis by t cells; and (4) the ability of b cells to produc ... | 1991 | 1646046 |
| the efficacy of fiberoptic endoscopic examination and biopsy in the detection of early nasopharyngeal carcinoma. | fiberoptic endoscopic examination and biopsy of the nasopharynx was done in 130 patients as a prospective study. they all had elevated titers of antibodies against the viral capsid antigen of epstein-barr virus but no symptoms or signs of nasopharyngeal carcinoma. each underwent a biopsy from six fixed sites in the nasopharynx. of the 780 biopsy specimens taken from seven patients, 11 showed the presence of nasopharyngeal carcinoma. techniques to improve the yields of such biopsies with fiberopt ... | 1991 | 1646070 |
| epstein-barr virus-associated lymphoproliferative syndromes: studies in two european families. | the x-linked lymphoproliferative syndrome (xlp), also known as duncan's disease, is an x-linked recessive disorder that is characterized by the inability of affected individuals to mount a sufficient immune response to epstein-barr virus (ebv). after ebv primary infection, male family members suffer from severe infectious mononucleosis (im), aplastic anemia, hypogammaglobulinemia, and a spectrum of lymphoproliferative diseases. autosomal mode of inheritance with similar symptoms as in xlp has be ... | 1991 | 1646073 |
| limiting-dilution analysis of the hla restriction of anti-epstein-barr virus-specific cytolytic t lymphocytes. | human epstein-barr virus (ebv) specific cytotoxic t lymphocytes (ctl) play an important role in maintaining the virus/host equilibrium during persistent infections. we analysed precursors of anti-ebv ctl by the limiting-dilution technique. seven healthy ebv-seropositive and two ebv-seronegative donors were tested. all the donors seropositive for ebv gave clear-cut positive results, and it was remarkable that the frequency of ctl precursors (ctlp) observed was much higher than that reported for o ... | 1991 | 1646086 |
| [infectious mononucleosis]. | | 1991 | 1646131 |
| establishment and characterization of epstein-barr virus gp350-expressing transfected human lymphoid (raji) cell clones. | gp350, a late epstein-barr-virus (ebv) glycoprotein expressed on both the envelope of viral particles and ebv-producing cells, is also the candidate for the development of an anti-ebv subunit vaccine. this glycoprotein is thought to play an important role in anti-ebv immunity. however, studies on the role of this viral antigen in cellular cytotoxicity and other immune functions have been hampered by the lack of a suitable model expressing gp350. we describe here a study in which we successfully ... | 1991 | 1646179 |
| [molecular mimicking in rheumatic inflammatory pathogenesis]. | | 1991 | 1646448 |
| detection of epstein-barr virus in lymphoepithelioma-like carcinoma of the lung. | a case of lymphoepithelioma-like carcinoma of the lung is reported in a chinese patient with serologic evidence of previous epstein-barr (ebv) infection. ebv genomes were detected in the tumor using polymerase chain reaction (pcr) and in situ hybridization (ish) from formalin-fixed, paraffin-embedded tissue blocks. the use of both techniques afforded the exquisite sensitivity of pcr to detect a few copies of ebv dna with the ability of ish to precisely localize ebv to the carcinoma, but not to t ... | 1991 | 1646459 |
| epstein-barr virus and malignant lymphoepithelial lesions of the salivary gland. | this report describes the results of histopathologic and virologic studies in six patients with undifferentiated carcinoma (malignant lymphoepithelial lesions) of the salivary glands. epstein-barr virus (ebv) was detected in tumors from all six patients by dna hybridization, while adjacent non-tumorous salivary gland tissue was negative for ebv in two patients tested for dna and in three patients tested for epstein-barr nuclear antigen (ebna). these findings add more evidence that these unusual ... | 1991 | 1646614 |
| heterogeneity in the reactivity of various groups of igm antibodies with kaolin. | kaolin strongly adsorbed rheumatoid factor (rf) and mono-nucleosis antibodies, while cold agglutinins and some antimicrobial igm antibodies were poorly adsorbed. maximum adsorption took place at a ph of about 7. the degree of adsorption also depended on the amount of kaolin. rheumatoid factor could be eluted from kaolin at ph 11 after adsorption at ph 7. the reported heterogeneity with regard to reactivity with kaolin is suggested to be due to hydrophobic interactions. | 1991 | 1646618 |
| effect of transforming growth factor-beta 1 and -beta 2 on the proliferation of burkitt lymphoma and lymphoblastoid cell lines. | we tested the effect of transforming growth factor (tgf)-beta 1 and tgf-beta 2 on the proliferation of human b cell lines. the panel was selected to give information whether (1) their origin, (2) their phenotype, (3) their epstein-barr virus (ebv) carrier state, influence their responsiveness. the growth of lymphoblastoid cell lines (lcl) was not inhibited by tgf-beta 1. the ebv-carrying burkitt lymphoma (bl) lines, daudi, jijoye, rael but not raji were inhibited. three ebv-negative bl lines and ... | 1991 | 1646619 |
| an epidemiologist's view of the new molecular biology findings in hodgkin's disease. | recent advances in molecular biology provide new strategies to address the pathogenesis of hodgkin's disease (hd). immunophenotyping studies of reed-sternberg cells suggest lymphoid cells, 'frozen in a state of activation.' clonal rearrangement studies find heavy and light chain immunoglobulin and beta and gamma t-cell receptor gene changes. chromosomal studies find a complex but nonrandom mixture of structural rearrangements including many seen in other hematologic disorders. these findings are ... | 1991 | 1646623 |
| the nature of hodgkin and reed-sternberg cells, their association with ebv, and their relationship to anaplastic large-cell lymphoma. | this review focuses on the cellular origin of hodgkin and reed-sternberg (hrs) cells, their association with the epstein-barr virus (ebv), and their relation to ki-1+ anaplastic large-cell (alc) lymphoma. the tingibility of hrs cells in paraffin sections for polyclonal immunoglobulin represents a staining artifact and thus can no longer serve as an argument for the histiocytic nature of hrs cells. immunolabeling studies do not support the putative relationship of hrs cells to cell types such as ... | 1991 | 1646624 |
| modulation of human lymphoblastoid b cell line by phorbol ester and sphingosine. a 31p-nmr study. | changes in phospholipid and energy metabolism in epstein-barr virus transformed b lymphocytes (ebv-b), induced by phorbol 12,13-dibutyrate (pd) and sphingosine (an inhibitor of protein kinase c), have been evaluated by 31p-nmr spectroscopy. the effects of pd and sphingosine on [3h]thymidine incorporation have also been studied. an increase in phosphorylcholine (pcho) levels has been observed in sphingosine and sphingosine + pd treated cells after 30 min of incubation, whereas no change was obser ... | 1991 | 1646646 |
| insulin receptor gene expression is reduced in cells from a progeric patient. | we have studied a 15-year-old girl (p1) suffering from the hutchinson-gilford syndrome (progeria) associated with a severe insulin resistance. insulin binding activity to p1 erythrocytes was 85% reduced when compared to that measured in ten normal controls matched for sex and age. this finding was confirmed in epstein-barr virus (ebv)-transformed lymphoblasts and depends on a reduction in insulin receptor number. also the amount of total insulin receptors, [35s]methionine labeled and immunopreci ... | 1991 | 1646740 |
| epstein-barr virus transformation of saimiri sciureus (squirrel monkey) b cells and generation of a plasmodium brasilianum-specific monoclonal antibody in p. brasilianum-infected monkeys. | the new-world monkeys saimiri sciureus (squirrel monkeys) are currently used as a model to test the efficacy of vaccines against human malaria. to improve our knowledge on this model, we tested the susceptibility of s. sciureus b cells to epstein-barr virus (ebv) infection. b-lymphoblastoid cell lines were obtained from six of six healthy animals after infection with the b95-8 source of ebv. the frequency distributions of spleen b cells clonally committed to the production of immunoglobulins m a ... | 1991 | 1646769 |
| model for studying virus attachment. ii. binding of biotinylated human t cell leukemia virus type i to human blood mononuclear cells potential targets for human t cell leukemia virus type i infection. | purified human t cell leukemia virus type i (htlv-i) was biotinylated and used to study its attachment to human pbmc. the use of biotinylated htlv-i (biot-htlv-i) in conjunction with mouse mab specific for selected cell-surface molecules and flow cytometric analysis allowed us to positively identify virus-binding cells among a heterogeneous blood mononuclear cell population. biot-htlv-i efficiently bound not only to t cells, but also to b cells and monocytes. preincubation of monocytes with exce ... | 1991 | 1646840 |
| acute sporadic hepatitis in sudanese children. | eighty consecutive cases of acute viral hepatitis and 80 controls selected from a public pediatric clinic were entered into a study of acute sporadic hepatitis in khartoum, sudan. study subjects were 14 years of age or younger and were mainly from a low socioeconomic level. non-a, non-b hepatitis was diagnosed by exclusion in 35 (43.8%) patients, hepatitis a in 27 (33.8%), acute hepatitis b in 8 (10.0%), possible epstein-barr virus (ebv) hepatitis in 1 patient; and dual hepatitis a and b infecti ... | 1991 | 1646853 |
| presence of antibody to cyno-ebv in domestically bred cynomolgus monkeys (macaca fascicularis). | the presence of an antibody to the cyno-ebv was studied with cyno-ebv bearing cell line (ts-b-9) as antigen in 186 domestically bred cynomolgus monkeys (macaca fascicularis) ranging in age from birth to 18 yr as well as in 20 adult (older than 10 yr) cynomolgus monkeys of wild origin. the maternal antibody to cyno-ebv persisted for less than four mo after birth in infant monkeys. after one yr of age, all the domestically bred monkeys were consistently positive for cyno-ebv. in the monkeys of wil ... | 1991 | 1646886 |
| case records of the massachusetts general hospital. weekly clinicopathological exercises. case 29-1991. a 56-year-old woman with pneumoperitoneum three months after receiving a renal transplant. | | 1991 | 1646963 |
| epstein-barr virus latent membrane protein expression in hodgkin and reed-sternberg cells. | cryostat sections from lymph nodes of 47 hodgkin disease patients were examined by immunohistology for the epstein-barr virus (ebv)-encoded latent membrane protein (lmp), nuclear antigen 2, and late viral glycoprotein gp350/250. a distinct lmp-specific membrane and cytoplasmic staining was detected exclusively in hodgkin and reed-sternberg cells in 18 patients (38%); ebv nuclear antigen 2 and gp350/250 immunoreactivity was absent in all instances. thirty-two of 47 (68%) cases contained ebv-speci ... | 1991 | 1647016 |
| abundant expression of eber1 small nuclear rna in nasopharyngeal carcinoma. a morphologically distinctive target for detection of epstein-barr virus in formalin-fixed paraffin-embedded carcinoma specimens. | the highly restricted expression of the epstein-barr virus (ebv) genome in malignancy has limited the use of ebv detection methods applicable to formalin-fixed paraffin-embedded carcinoma specimens. in ebv-transformed lymphocytes very short nonprotein coding ebv transcripts (ebers) are expressed in much higher abundance (10(7) copies per cell) than other ebv latency transcripts. using a 3h riboprobe, the authors demonstrated eber1 expression in nasopharyngeal carcinomas (npcs) as well as in paro ... | 1991 | 1647139 |
| viral encephalitis. | nonherpetic encephalitis outside the newborn period is usually a self-limited disease. the majority of patients will recover without significant sequelae, and require only supportive therapy during the acute illness. though the underlying viral etiology frequently will escape detection, identification of the infecting agent has considerable prognostic value which can complement clinical measures of severity of disease. the most important initial task of the clinician faced with a case of presump ... | 1991 | 1647166 |
| epstein-barr virus antibodies and severity of depression. | | 1991 | 1647225 |
| [in vitro immunization of human lymphocytes with epstein-barr virus capsid antigen]. | conditions for in vitro immunization of human lymphocytes from adult peripheral blood, tonsils and cord blood with epstein-barr virus (ebv) capsid antigens have been studied. pokeweed mitogen and b cell growth factor from namalva cell line were shown to induce a significant production of specific antibodies by human lymphocytes stimulated with ebv. this effect made it possible to generate primary immune response in vitro using lymphocytes from ebv seronegative donors. | 1991 | 1647234 |
| relating homology between the epstein-barr virus bolf1 molecule and hla-dqw8 beta chain to recent onset type 1 (insulin-dependent) diabetes mellitus. | a role for the epstein-barr virus in initiating type 1 (insulin-dependent) diabetes mellitus has been proposed since epstein-barr virus bolf1 (497-513) avtpl rifivppaaey has an 11 amino acid identity with hla-dqw8 beta (49-60) avtpl gppaaey. rabbit antisera to the bolf1 (496-515) peptide crossreacted with the homologous dqw8 beta (44-63) peptide but not with the related dqw7 beta (44-63) peptide, which differed from the dqw8 peptide only in an ala to asp substitution in position 57. antisera to ... | 1991 | 1647336 |
| impairment of natural killer functions by interleukin 6 increases lymphoblastoid cell tumorigenicity in athymic mice. | expression of the human il-6 gene in ebv-immortalized normal human b lymphocytes following retroviral-mediated transduction rendered these cells highly tumorigenic in athymic mice. the tumors were lymphomas composed of the originally inoculated human lymphoblastoid cells. co-injection of il-6 expressing ebv-immortalized cells with il-6 nonexpressing control cells resulted in increased tumorigenicity of the il-6 nonexpressing cells. the lymphoblastoid cells expressing il-6 were indistinguishable ... | 1991 | 1647416 |
| spontaneous in vitro secretion of antibody to cytomegalovirus (cmv) by human peripheral blood mononuclear cells: a new approach to studying the cmv-immune system interaction. | the in vitro secretion of cytomegalovirus (cmv)-specific antibodies by peripheral blood mononuclear cells (pbmc) was analyzed in patients with acute cmv infection and cmv-seropositive patients infected with human immunodeficiency virus. this active and spontaneous in vitro secretion was not affected by the depletion of t cells or adherent cells. the number of anti-cmv antibody-secreting cells was estimated to be 28-176/10(6) pbmc; 30%-65% of the total in vitro antibody production was cmv-specifi ... | 1991 | 1647420 |
| study of epstein-barr virus (ebv) transmission by ebv genotyping. | | 1991 | 1647423 |
| analysis of antibody titers to epstein-barr virus nuclear antigens in sera of patients with sjögren's syndrome and with rheumatoid arthritis. | to examine if epstein-barr virus (ebv) infection is associated with the two autoimmune diseases, sjögren's syndrome and rheumatoid arthritis, igg antibody titers of sera from patients with the disorders were evaluated for five constituents of ebv nuclear antigens (ebna-1, -2, -3, -4, and -6). to circumvent interference by autoantibodies in the sera, fusion proteins synthesized in escherichia coli were used as specific antigens. by elisa the average igg antibody titers to domains of the five ebna ... | 1991 | 1647426 |
| ebv genome and immunoglobulin gene rearrangement in the differential diagnosis of nasopharyngeal carcinoma and lymphoma. | head and neck tumors include nasopharyngeal carcinoma (npc) and lymphoma. the differential diagnosis of these tumors is based on histology, immunocytochemical staining, and ebv serology. in rare cases it might be difficult to distinguish between npc and lymphoma in he section or biopsies. dna hybridization with cloned ebv and human immunoglobulin gene fragments allows the detection of ebv-related sequences and immunoglobulin gene rearrangements. the presence of ebv genome supports the diagnosis ... | 1991 | 1647489 |
| an epstein-barr virus-producer line akata: establishment of the cell line and analysis of viral dna. | an epstein-barr virus (ebv)-producer line, designated akata, was established from a japanese patient with burkitt's lymphoma. the akata line possessed the burkitt's-type chromosome translocation, t(8q- ; 14q+), and was derived from the tumor cell. akata cells produced a large quantity of transforming virus upon treatment of cells with anti-immunoglobulin antibodies (takada, 1984). southern blot analysis of viral dna indicated that the akata ebv is nondefective and more representative of wild-typ ... | 1991 | 1647567 |
| infectious mononucleosis. diagnosis by in situ hybridization in two cases with atypical features. | two cases of infectious mononucleosis are reported in which in situ hybridization studies were of use to distinguish this disorder from non-hodgkin's lymphoma. one patient was an 80-year-old man with a tonsillar mass that histologically resembled non-hodgkin's lymphoma and, on fixed tissue immunohistochemistry, appeared to contain a population of cells anomalously coexpressing the b-cell marker l26 and the t-cell marker leu-22, suggesting diffuse large-cell non-hodgkin's lymphoma. the second pat ... | 1991 | 1647703 |
| hairy leukoplakia-like lesions following bone-marrow transplantation. | hairy leukoplakia (hl) also occurs in immunosuppressed post-bone-marrow transplantation patients, and in the presence or absence of epstein-barr virus. it may not always be diagnostic of hiv positivity. however, hiv status should still be determined in patients with hl. | 1991 | 1647786 |
| suppressive t cell function of epstein-barr virus induced b cell activation in active behçet's disease. | b and t cell function were studied in 10 patients with active behçet's disease (bd) and in 10 normal subjects. peripheral b lymphocytes infected with epstein-barr virus (ebv) were cultured for 20 days in the presence or absence of autologous t cells. immunoglobulin m and g secretions into the supernatants were assessed with an enzyme-linked immunosorbent assay. the extent of suppression of ebv-induced b cell activation by autologous t cells was significantly decreased in active bd patients as co ... | 1991 | 1647911 |
| activation of epstein-barr virus promoters by a growth-factor and a glucocorticoid. | transforming growth factor-beta (tgf-beta) and a glucocorticosteroid, dexamethasone (dxm), both cause transcriptional induction of epstein-barr virus (ebv) early antigens (ea) in daudi lymphoma cells. the viral induction occurs through the viral promoter dr overlapping an origin of replication which is active during the lytic cycle. each hormone requires specific regions on the dr promoter. since these regions also mediate the action of two viral transcription factors, eb1 and r, it may be empha ... | 1991 | 1647975 |
| expression of functional human epstein-barr virus/c3d receptor ([cr2] cd21) on insulinoma cell line. induction of tumor rejection but not diabetes in syngeneic rats. | we stably expressed human complement receptor 2 ([cr2] cd21 c3d/epstein-barr virus [ebv] receptor) on the rat insulinoma cell line rinm5f with a recombinant retroviral vector. cr2-expressing rinm5f cells secreted 78-33% less insulin than parental cells or cells transduced with an antisense vector and could be infected with high-titer ebv. we tested whether human cr2 expression on rinm5f cells would affect tumorigenesis after transplantation to syngeneic new england deaconess hospital rats. non-c ... | 1991 | 1647992 |
| infectious mononucleosis in adolescents. | infectious mononucleosis is a clinical manifestation of primary ebv infection in adolescents, characterized by a triad of clinical, laboratory, and serologic features. the classic signs and symptoms are not seen in every patient; rather, the presentations tend to fit into one of three clinical forms (pharyngeal, glandular, or febrile). recognizing these syndromes provides a useful framework for anticipating the clinical course, complications, and differential diagnosis. nonclassic presentations ... | 1991 | 1648197 |
| chronic fatigue in children: clinical features, epstein-barr virus and human herpesvirus 6 serology and long term follow-up. | during a 2-year period, 23 patients (14 girls, 9 boys) with chronic fatigue were referred to the pediatric infectious disease clinic of a tertiary care center, representing 19% of all out-patients seen in that clinic during that time. the median age was 14 years and the median duration of symptoms before referral was 6 months; 65% had missed at least 2 weeks of school and 30% required a home tutor. there were few positive physical findings and no elevation of white blood cell count (median, 7000 ... | 1991 | 1648198 |
| [mononucleosis syndromes. diagnostic orientation]. | | 1991 | 1648256 |
| role of vicia villosa-adherent cd8+ t cells in the immune response to epstein-barr virus. | epstein-barr virus (ebv) is a lymphotropic human herpesvirus which is also a polyclonal b-cell activator. we show here that vicia villosa-adherent cd8+ t (vv-t) cells, which have a contrasuppressive activity, play an important role in the b-cell response to ebv and that t-helper cells are not required for antibody production against ebv particles. we have examined this activity by measuring anti-ebv igm antibody production by b cells in vitro in the presence and the absence of both t-helper and ... | 1991 | 1648359 |
| establishment and characterization of a b-cell line derived from a patient with a myelodysplastic syndrome which expresses myelomonocytic and lymphoid markers. | we describe a novel continuous b-cell line (pv-90) derived from a patient with myelodysplastic syndrome (mds) and originating from spontaneous infection with the epstein-barr virus (ebv). the patient progressed to acute myeloblastic leukaemia (aml) 5 months after clinical onset of mds. pv-90 is of clonal origin as indicated by the presence of immunoglobulin (ig) gene rearrangements, monoclonal surface immunoglobulins, and a single dna restriction fragment corresponding to the ebv genomic termini ... | 1991 | 1648372 |
| [possible etiological relations between sjogren's syndrome and epstein-barr virus]. | tissue biopsies from patients with sjogren's syndrome (ss) and controls were detected by a monoclonal antibody (mcab) of gene engineering against epstein-barr virus (ebv) encoded early antigen (ea p138) and a 32p-labelled ebv dna probe, and also b95-8 and k4 cells as antigens to detect reacting antibodies to ebv in patients' sera. as a result, cytoplasmic fluorescence staining of epithelial cells with the mcab as described above was noted in 15/33 labial and 7/7 renal biopsies from primary ss. t ... | 1991 | 1648423 |
| programmed cell death: apoptosis and oncogenesis. | | 1991 | 1648446 |
| induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected b cells from programmed cell death. | epstein-barr virus (ebv) not only induces growth transformation in human b lymphocytes, but has more recently been shown to enhance b cell survival under suboptimal conditions where growth is inhibited; both effects are mediated through the coordinate action of eight virus-coded latent proteins. the effect upon cell survival is best recognized in ebv-positive burkitt's lymphoma cell lines where activation of full virus latent gene expression protects the cells from programmed cell death (apoptos ... | 1991 | 1648447 |
| activity of soluble factors produced by epstein-barr virus-transformed human b lymphocytes on different cell lines. | self-stimulatory growth factors, produced by a human epstein-barr virus (ebv)-positive lymphoblastoid b cell line, named ba-d10-4, have been tested for the capacity to induce dna synthesis in various human and animal cell lines, including lymphoid, either ebv-positive or ebv-negative, and non-lymphoid cell lines. it has been found that ba-d10-4 cells produce growth factors which seem to be essential for their sustained proliferation in vitro, and which increase dna synthesis in different primate ... | 1991 | 1648507 |
| constitutional extra chromosomal element in a family with wilms' tumor. | we report the presence of an extra chromosomal element in a family with wilms' tumor (wt). this family has three children, two of whom were affected. one son, the proband, had bilateral and one daughter had unilateral wt. the first child, the father, and the mother did not have wt. the son with bilateral wt had a ring chromosome (r) both in the lymphocytes as well as in the kidney tissue. the size of the ring varied considerably from cell to cell. the daughter with unilateral wt had an abnormal ... | 1991 | 1648545 |
| the use of labeled fusion protein for detection of b19 parvovirus igm antibodies by an immunocapture test. | a new anti-b19 igm elisa was developed taking advantage of antibody-capture with biotinylated fusion protein as antigen. specificity was examined using serum igm antibody positive for rubella, hepatitis b core antigen, cytomegalovirus and epstein-barr virus as well as with sera positive for rheumatoid factors or antinuclear antibodies. the specificity was found to be 96%. of one hundred serum samples compared using the new elisa or the standard macria tests for the presence of b19 igm, 88 gave t ... | 1991 | 1648571 |
| detection of single copies of epstein-barr virus in paraffin wax sections by non-radioactive in situ hybridisation. | a highly sensitive non-isotopic in situ hybridisation technique was developed for the localisation of epstein-barr virus (ebv) in paraffin wax embedded tissue sections. the method uses a repeated sequence of the ebv genome as a probe, labelled with the novel reporter molecule, digoxigenin. the method can identify individual copies of ebv by detection of both ebv dna and highly localised rna transcripts. a combination of careful proteolytic digestion of tissue sections, high temperature denaturat ... | 1991 | 1648578 |
| detection of epstein-barr virus sequences in primary brain lymphoma without immunodeficiency. | we searched for epstein-barr virus (ebv) sequences by enzymatic dna amplification in nine primary brain lymphomas from patients without immunodeficiency. we used seven nonlymphoma brain tumors as negative controls, and the raji cell line as a positive control. we detected ebv dna, using ethidium bromide-stained-agarose minigel electrophoresis and dot blot hybridization, in the positive control and in only one brain lymphoma tumor; we did not detect ebv dna in the other tumors. the ebv-positive p ... | 1991 | 1648683 |
| absence of epstein-barr virus activation in htlv-i-associated tropical spastic paraparesis. | | 1991 | 1648684 |
| restricted epstein-barr virus protein expression in burkitt lymphoma is due to a different epstein-barr nuclear antigen 1 transcriptional initiation site. | epstein-barr virus (ebv) expresses six nuclear antigens (ebnas) and three integral latent membrane proteins (lmps) in latently infected growth-transformed b lymphoblastoid cell lines (lcls). in contrast, ebv protein expression in burkitt lymphoma tissue or in newly established burkitt lymphoma cell lines is frequently restricted to the ebv genome maintenance protein, ebna-1. ebna-1 expression in the absence of other ebnas and lmp-1 has been an enigma since, in lcls, all ebna mrnas are processed ... | 1991 | 1648738 |
| antibodies to epstein-barr virus in patients with chronic fatigue. | to clarify the role of epstein-barr virus (ebv) infection and the value of ebv antibody testing in evaluating patients with chronic fatigue, we studied 200 consecutive patients with chronic fatigue (mean duration, 9 years). complete ebv serologic panels were obtained for 154 patients, 35 (23%) of whom met serologic or clinical criteria for chronic or reactivated ebv infection. we compared these patients with chronic ebv infection (cebv cases) to 35 age- and sex-matched patients who were selected ... | 1991 | 1648795 |
| lymphomas following cardiac transplantation. case report and review of the literature. | the success of allogeneic organ transplantation is in great part due to pharmacologic advances in the area of immunosuppressive therapy. however, this achievement has been attained at the price of an unexpectedly high incidence of malignancies in this transplant population. lymphoid malignancies predominate in this and other immunodeficiency states. there is some controversy in the literature over the clonal or malignant nature of these proliferations. this paper presents a case of burkitt-like ... | 1991 | 1648879 |
| role of a new cytokine, interleukin-10, in the cross-regulation of t helper cells. | | 1991 | 1648883 |
| the role of il-10 in crossregulation of th1 and th2 responses. | the identification of helper t (th)-cell subsets has greatly improved understanding of the regulation of immune effector functions. in addition to controlling humoral and delayed-type hypersensitivity responses, these subsets crossregulate by secreting mutually inhibitory cytokines. in this review, tim mosmann and kevin moore examine these phenomena and in particular the role of interleukin 10, a cytokine secreted by th2 cells that inhibits th1-cell function. | 1991 | 1648926 |
| regulation of human b cell proliferation and differentiation by seminal plasma. | to investigate the role of seminal plasma in human b cell functions, its effect on the proliferation and antibody secretion of tonsillar b cells and an epstein-barr virus (ebv) transformed human b cell line, a4, was examined. seminal plasma inhibited both the proliferation and differentiation of normal b cells only when added to the cultures at the early period of culture. if addition of seminal plasma was delayed beyond 5 to 6 days, it failed to inhibit igg secretion. seminal plasma did not sho ... | 1991 | 1649020 |
| detection of anti-epstein-barr-virus transactivator (zebra) antibodies in sera from patients with nasopharyngeal carcinoma. | the epstein-barr virus (ebv) is a ubiquitous herpes virus which causes infectious mononucleosis and is associated with such different neoplasms as burkitt's lymphoma and nasopharyngeal carcinoma. ebv latently infects its target cells; nevertheless, evidence of viral replication in npc tumours has been uncovered. among the ebv transactivators, the zebra protein plays a crucial role in switching the virus from a latent to a productive mode. zebra protein was produced using a eukaryotic expression ... | 1991 | 1649137 |
| the epstein-barr-virus-encoded membrane protein lmp but not the nuclear antigen ebna-1 induces rejection of transfected murine mammary carcinoma cells. | the ebv-encoded membrane protein (lmp) and the nuclear antigen ebna-1 were compared for their capacity to induce rejection of transfected murine mammary carcinoma cells in syngeneic hosts. the tumorigenic potential of stable lmp and ebna-1 expressing sublines of the aca (h-2f)-derived mammary carcinoma line s6c was tested in pre-immunized syngeneic and semi-syngeneic animals. lmp expressing s6c cells elicited a strong rejection response as demonstrated by the lower tumor take and slower growth i ... | 1991 | 1649140 |