| carcinoma of the external auditory canal and middle ear. | to evaluate therapeutic modalities used at our institutions regarding local control, disease-free survival and actuarial survival in carcinoma of the external auditory canal and middle ear, in an attempt to provide guidelines for therapy. | 1999 | 10386634 |
| rectal cancer and inflammatory bowel disease: natural history and implications for radiation therapy. | there exists little information concerning the natural history of rectal cancer in patients with inflammatory bowel disease (ibd). in addition, the tolerance of pelvic irradiation in these patients is unknown. we analyzed the largest series of patients with ibd and rectal cancer in order to determine the natural history of the disease as well as the effect and tolerance of pelvic irradiation. | 1999 | 10386640 |
| long-term behavioral effects of repetitive pain in neonatal rat pups. | human preterm neonates are subjected to repetitive pain during neonatal intensive care. we hypothesized that exposure to repetitive neonatal pain may cause permanent or long-term changes because of the developmental plasticity of the immature brain. neonatal rat pups were stimulated one, two, or four times each day from p0 to p7 with either needle prick (noxious groups n1, n2, n4) or cotton tip rub (tactile groups t1, t2, t4). in groups n2, n4, t2, t4 stimuli were applied to separate paws at hou ... | 1999 | 10386907 |
| sliding clamp of the bacteriophage t4 polymerase has open and closed subunit interfaces in solution. | the sliding clamps of bacteriophage t4 (gp45), escherichia coli (beta clamp), and yeast (pcna) are required for processive dna synthesis by their cognate dna polymerases. the x-ray crystal structures of all three of these clamps have been shown to be closed, circular complexes. this paper reports investigations of the solution structure of bacteriophage t4 gp45 by analytical ultracentrifugation, fluorescence, and hydrodynamic modeling. mutants of gp45 with inter- and intrasubunit disulfide bonds ... | 1999 | 10387009 |
| side-chain and backbone flexibility in protein core design. | we have developed a computational approach for the design and prediction of hydrophobic cores that includes explicit backbone flexibility. the program consists of a two-stage combination of a genetic algorithm and monte carlo sampling using a torsional model of the protein. backbone structures are evaluated either by a canonical force-field or a constraining potential that emphasizes the preservation of local geometry. the utility of the method for protein design and engineering is explored by d ... | 1999 | 10388574 |
| evaluation of a simplified staging system for prognosis of hepatocellular carcinoma. | the current tnm (tumor, nodes, metastases) staging system for human hepatocellular carcinoma (hcc) has been challenged since a new t staging system was proposed to correlate the staging group with patient outcome after curative liver resection. the new t staging system proposed t1 as no vascular invasion, small size (< or = 5 cm), and solitary tumor. t2 was defined as the presence of one of the following factors: size greater than 5 cm, vascular invasion, or multiple tumors; t3 as the presence o ... | 1999 | 10389368 |
| psychological, clinical and pathological effects of relaxation training and guided imagery during primary chemotherapy. | the diagnosis and treatment of breast cancer are stressful, and stress may be associated with a poorer response to chemotherapy. there is a need, therefore, to develop and evaluate interventions that might enhance quality of life and, possibly, improve treatment response. the effects of relaxation combined with guided imagery (visualizing host defences destroying tumour cells) on quality of life and response to primary chemotherapy, to date, have not been adequately evaluated. ninety-six women w ... | 1999 | 10390006 |
| cadmium induced thyroid dysfunction in chicken: hepatic type i iodothyronine 5'-monodeiodinase activity and role of lipid peroxidation. | administration of cadmium chloride (2.5 mg/kg body weight/day) to chickens daily for 15 days decreased serum triiodothyronine (t3) concentration (by 68.75%) without altering the levels of serum thyroxine (t4). hepatic 5'-monodeiodinase (5'd-i) and superoxide dismutase (sod) activities were also decreased (by 90.47% and 20.81% respectively) with a concomitant increase in lipid peroxidation (lpo, by 206.25%). administration of the antioxidant vitamin e (alpha-tocopherol, 5 mg/kg body weight on alt ... | 1999 | 10390054 |
| the use of nuclear morphometry for the prediction of survival in patients with advanced cancer of the larynx. | we examined retrospectively whether the quantitative morphometric analysis of nuclear shapes in patients with advanced cancer of the larynx could be used as a prognostic factor. in all, specimens were taken from 90 patients treated by surgery in the department of otolaryngology, jagiellonian university, cracow, poland, between 1987 and 1988. the follow-up period was no shorter than 5 years. in the group examined there were 59 patients with t3 tumors and 31 with t4 tumors. a neck dissection was p ... | 1999 | 10392302 |
| persistent efficacy of doramectin injectable against artificially induced infections with cooperia punctata and dictyocaulus viviparus in cattle. | three studies were conducted to evaluate the persistent efficacy of doramectin injectable solution against experimental challenges with infective larvae of cooperia punctata and dictyocaulus viviparus. in each study, four groups of ten randomly-assigned calves, negative for trichostrongyle-type eggs on fecal examination, were treated subcutaneously in the midline of the neck with saline (1 ml/50 kg) on day 0 or doramectin (200 microg/kg = 1 ml/50 kg) on day 0, 7, or 14. two additional calves fro ... | 1999 | 10392767 |
| assaying rna chaperone activity in vivo using a novel rna folding trap. | in the absence of proteins, rnas often misfold in vitro due to alternative base pairings which result from the molecule being trapped in inactive conformations. we identify an in vivo folding trap in the t4 phage td gene, caused by nine base pairs between a sequence element in the upstream exon of the td gene and another at the 3' end of the intron. during translation, the ribosome resolves this interaction; consequently the intron folds correctly and splicing occurs. the introduction of a stop ... | 1999 | 10393192 |
| results of fast neutron therapy of adenoid cystic carcinoma of the salivary glands. | patients with adenoid cystic carcinoma (acc) of the salivary glands in the head and neck region have been reported to benefit from neutron radiotherapy according to significant clinical experience. a prospective clinical trial on the efficacy and treatment related morbidity of fast neutron radiotherapy was performed between 1986 and 1995 at the (d + t) 14 mev neutron generator in münster. | 1999 | 10394401 |
| conformal proton beam therapy of prostate cancer--update on the loma linda university medical center experience. | the ability to eradicate localized prostate cancer is dependent upon the radiation dose which can be delivered to the prostate. this dose is often limited by the tolerance of normal organs (rectum, bladder). conformal beam therapy takes advantage of the unique depth dose characteristics of heavy charged particles (the bragg peak) to escalate the radiation dose delivered to the prostate while minimizing treatment-related toxicity. | 1999 | 10394406 |
| hypercalcemia in an euthyroid patient with secondary hypoadrenalism and diabetes insipidus due to hypothalamic tumor. | a 20-year-old japanese man with a hypothalamic tumor (most likely germ-cell tumor) which caused secondary hypoadrenalism, hypogonadism and diabetes insipidus developed hypercalcemia and acute renal failure. the serum levels of intact pth (ipth), pth-related protein (pth-rp), 1,25-dihydroxy vitamin d (1,25- (oh)2 d), acth, cortisol, gonadotropins and testosterone were decreased, but his serum levels of triiodothyronine (t3) and thyroxine (t4) were within the normal range at admission, with depres ... | 1998 | 10395233 |
| low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. | maternal thyroid function during early pregnancy is an important determinant of early fetal brain development because the fetal thyroid is unable to produce any t4 before 12-14 weeks' gestation. overt maternal hypothyroidism as seen in severe iodine-deficient areas is associated with severely impaired neurological development of the offspring. at present, it is not known whether low free t4 (ft4) levels during pregnancy in healthy women from iodine sufficient areas may affect fetal neurodevelopm ... | 1999 | 10396355 |
| comparison of serum thyrotrophin concentrations determined by a third generation assay in patients with various types of overt and subclinical thyrotoxicosis. | recent increases in the sensitivity of methods used to measure tsh, especially third generation assays, have enabled separation of partial from complete pituitary suppression in patients with thyrotoxicosis. we have investigated the use of a sensitive chemiluminescent enzymeimmunoassay in the differential diagnosis of thyrotoxicosis. | 1999 | 10396360 |
| [transcutaneous radiotherapy after thyroidectomy for differentiated thyroid carcinoma]. | to compare the results, in terms of 10-year actuarial survival, between i-131-therapy and i-131-therapy + external beam radiotherapy (rt) in patients operated on for differentiated thyroid carcinoma. | 1999 | 10396858 |
| activity losses among t4 lysozyme charge variants after adsorption to colloidal silica. | enzyme structure and function depend to some extent on enzyme net charge and charge location. altering the charge of even a single residue may affect the interaction between enzyme and substrate such that all catalytic activity is lost. in this study we investigated the effect of net charge and charge location on the enzymatic activity of synthetic mutants of bacteriophage t4 lysozyme in the presence of colloidal silica. enzymatic activity decreased upon adsorption, and these changes were varian ... | 1999 | 10397875 |
| cd40 expression in bladder cancer. | the cd40 receptor is expressed in many immune cell types and is known to play a central role in both humoral and t-cell-mediated immunity, being a subject of intense research interest in recent years. it is also expressed on a variety of carcinomas and may therefore be of biological significance in the development and treatment of cancer. the expression of cd40 was examined immunohistochemically in a series of 131 bladder transitional cell carcinomas and the correlation with known prognostic mar ... | 1999 | 10398138 |
| [acute symptom transverse laminectomy for a benign osteoclastoma of thethoracic spine--case report and review of the literature]. | benign osteoclastomas of the spine above the sacrum are uncommon lesions. acute paraparesis as the presenting sign of disease is unusual and rarely described in the literature. we report on the case of a 41 yrs old male who underwent acute t3-5 laminectomy for spinal cord decompression from a t4 expansive mass lesion with locally destructive growth. although a malignant lesion was suspected, definitive histologic examination disclosed a benign osteoclastoma. therefore, elective trans-thoracic to ... | 1999 | 10399268 |
| [clinico-laboratory algorithms for assessing the functional activity of the thyroid gland]. | three diagnostic algorithms making use of automated chemiluminescent analyzers are proposed for evaluation of the thyroid function, depending on the clinical situation. laboratory criteria of hypothyrosis and thyrotoxicosis therapy monitoring are discussed. main variants of disagreement between clinical data and values of thyrotropic hormone and free t4 are presented. | 1999 | 10399436 |
| treatment of hypopituitarism in infancy. effect on head circumference growth. | head circumference of children with multiple pituitary-hormone deficiency (mphd) may be subnormal for age. moreover it is known that linear growth in infancy is growth-hormone (gh) dependent. therefore, aim of the study has been to compare head circumference measurements in children with hypopituitarism after l-thyroxine (l-t4) therapy alone, before therapy with gh, and after gh was added to the therapy. | 1999 | 10399443 |
| uncoupling protein mrna, mitochondrial gtp-binding, and t4 5'-deiodinase activity of brown adipose tissue in daurian ground squirrel during hibernation and arousal. | the mrna level of uncoupling protein (ucp) specific for brown adipose tissue (bat) in daurian ground squirrel, was detected by using a [32p]-labeled oligonucleotide probe. the ucp concentration in mitochondria was indirectly determined by titration with its specific ligand [h3]-labeled gtp. type ii t4 5'-deiodinase of bat was assayed concomitantly. we found two species of mrna for ucp with lengths of about 1.9 and 1.5 kb, respectively, both occurring in almost the same concentration. ucp mrna co ... | 1998 | 10400495 |
| lysis and lysis inhibition in bacteriophage t4: rv mutations reside in the holin t gene. | upon infecting populations of susceptible host cells, t-even bacteriophages maximize their yield by switching from lysis at about 25 to 35 min at 37 degrees c after infection by a single phage particle to long-delayed lysis (lysis inhibition) under conditions of sequential infection occurring when free phages outnumber host cells. the timing of lysis depends upon gene t and upon one or more rapid-lysis (r) genes whose inactivation prevents lysis inhibition. t encodes a holin that mediates the mo ... | 1999 | 10400598 |
| molecular heterogeneity of oligodendrocytes in chicken white matter. | the classical studies by del rio hortega (mem. real. soc. espan. hist. nat. 14:40-122, 1928) suggest that the oligodendrocyte population includes four morphological subtypes. recent data from the cat and the rat show that the anatomy of oligodendrocytes related to early myelinating prospective large fibers differs from that of oligodendrocytes related to late myelinating prospective small fibers. after application of a polyclonal antiserum to cryostat sections from the chicken cns, we noted that ... | 1999 | 10401628 |
| treatment of the clinically negative neck in oral squamous cell carcinoma. | to define the most effect treatment plan of patients with oral cavity squamous cell carcinoma with clinically negative (no) neck staging. | 1999 | 10401861 |
| squamous cell carcinoma of the nasal vestibule. | sixty patients were treated with radiation therapy alone (56 patients) or followed by surgery (4 patients) between 1970 and 1995 for squamous cell carcinoma of the nasal vestibule. | 1999 | 10402517 |
| tissue-specific patterns of changes in 3,5,3'-triiodo-l-thyronine concentrations in thyroidectomized rats infused with increasing doses of the hormone. which are the regulatory mechanisms? | we have measured 3,5,3'triiodothyronine (t3) in 12 tissues from thyroidectomized (tx) rats infused with increasing doses of t3, and related them to their corresponding plasma levels. young adult wistar rats were surgically tx. after 4 weeks, the animals were infused with placebo or t3 (0.25, 0.50, 0.75, 1.00 or 2.00 microg/100 g body weight/day). placebo-infused intact rats served as euthyroid controls. plasma and samples of cerebral cortex, cerebellum, brown adipose tissue (bat), pituitary, liv ... | 1999 | 10403175 |
| the importance of thyroglobulin structure for thyroid hormone biosynthesis. | thyroglobulin (tg) is the most important protein in the thyroid because it provides the matrix for thyroid hormone biosynthesis. here we review experimental work, principally from our laboratory, on the relationship between tg structure and hormonogenesis. early work showed that tg's most important hormonogenic site was located in a fragment of approximately 26 kda obtained on chemical reduction. with the establishment of the cdna sequence of tg, this and other major sites could be localized wit ... | 1999 | 10403182 |
| mutation of the secys residue 266 in human type 2 selenodeiodinase alters 75se incorporation without affecting its biochemical properties. | type 2 deiodinase (d2) is a low km iodothyronine deiodinase that metabolizes thyroxine (t4) to the active metabolite t3. we have recently shown that the cdna for the human d2 coding region contains two in-frame selenocysteine (tga) codons. the 3' tga is seven codons 5' to a universal stop codon, taa. the human d2 enzyme, transiently expressed in hek-293 cells, can be in vivo labeled with 75se as a doublet of approximately 31 kda. this doublet is consistent with the possibility that the carboxy-t ... | 1999 | 10403186 |
| altered thyroid hormone binding to plasma lipoproteins in the syndrome of resistance to thyroid hormones. | lipoproteins, especially hdl, are carriers of a small fraction of the thyroid hormones in plasma and participate in the intracellular transport of t4. in previous work we showed that a brief period of hypothyroidism alters the hormone distribution among the lipoproteins, causing a decrease in vldl and ldl binding despite a relative increase in vldl and ldl cholesterol, an increase in hdl binding, and a reversal of t4 and t3 binding to the smallest hdl size subgroup. the present study of three pa ... | 1999 | 10403188 |
| hormone synthesis and storage in the thyroid of human preterm and term newborns: effect of thyroxine treatment. | iodine and thyroglobulin concentrations, as well as iodine, t3, t4 and sialic acid contents of thyroglobulin, were measured in thyroid glands collected postmortem from 42 human premature or term newborns and infants. three groups were considered: very preterm newborns (24-32 postmenstrual weeks, < 5 days postnatal life), preterm and term newborns (34-41 postmenstrual weeks, < 5 days postnatal life) and infants (born at term, postnatal age 1-8 months). five very preterm and seven preterm newborns ... | 1999 | 10403191 |
| dietary fat and protein interactions in the broiler. | an experiment was conducted to study the interrelationships between dietary fat and protein levels in the regulation of lipid metabolism in the broiler chicken. birds were fed diets containing 300, 600, or 1,200 kcal me from fat (corn oil) with either 124 or 190 g cp/kg. two additional experimental diets contained 234 or 285 g cp and 300 kcal me from fat. regardless of fat level, birds fed the diets containing 124 g cp/kg weighed less and were less efficient than birds fed diets containing 190 g ... | 1999 | 10404679 |
| the development of graves' disease and the ctla-4 gene on chromosome 2q33. | case-control studies suggest that the ctla-4 gene may be a susceptibility locus for graves' disease. the previously reported a/g polymorphism at position 49 in exon 1 of the ctla-4 gene was, therefore, investigated in a case-control (n = 743) and family-based (n = 179) dataset of white caucasian subjects with graves' disease. the relationship between ctla-4 genotype and severity of thyroid dysfunction at diagnosis was also investigated. an increase in frequency of the g (alanine) allele was seen ... | 1999 | 10404810 |
| thyroxine replacement therapy enhances clearance of chylomicron remnants in patients with hypothyroidism. | to further confirm the benefit of replacement therapy in terms of risk for coronary artery disease, we evaluated the effect of t4 on postprandial lipoproteins in patients with hypothyroidism. nine normolipidemic patients (aged 62.75+/-7.6 yr) with tsh of 32.2+/-13.2 mu/l and free t4 of 0.66+/-0.17 ng/ml were treated with t4 (50-100 microg/day) for at least 4 months. the behavior of postprandial lipoproteins was assessed before and during treatment by determining retinyl palmitate levels in the t ... | 1999 | 10404832 |
| sulfation of thyroid hormone by estrogen sulfotransferase. | sulfation is one of the pathways by which thyroid hormone is inactivated. iodothyronine sulfate concentrations are very high in human fetal blood and amniotic fluid, suggesting important production of these conjugates in utero. human estrogen sulfotransferase (sult1e1) is expressed among other tissues in the uterus. here we demonstrate for the first time that sult1e1 catalyzes the facile sulfation of the prohormone t4, the active hormone t3 and the metabolites rt3 and 3,3'-diiodothyronine (3,3'- ... | 1999 | 10404840 |
| performance and physiological variables in broiler chicken lines differing in susceptibility to the ascites syndrome: 2. effect of ambient temperature on partial efficiencies of protein and fat retention and plasma hormone concentrations. | 1. male broilers of 5 genetic stocks (a, b, c, d and e), selected in different ways for fast growth and low food conversion rate (fcr) and differing in sensitivity to ascites, were subjected to 2 different ambient temperature (ta) step-down programmes: normal (ht) and low (lt) ta. 2. ascites incidence was followed daily. growth and food intake were measured weekly. heat production (hp), oxygen consumption (oxc) and energy- metabolism parameters were calculated according to the comparative slaugh ... | 1999 | 10405051 |
| comparison of the assembly of the bacteriophage t4 clamp loader complex (gp44/62) expressed in a cis versus trans genomic configuration. | proper formation of the bacteriophage t4 dna polymerase holoenzyme requires a wide spectrum of protein-protein and protein-dna interactions among the dna polymerase gp43, the sliding clamp gp45, and gp44/62, the clamp loader complex (clc). the 44 and 62 proteins associate to form a tight complex maintained in a 4:1 ratio. the 44 and 62 genes are adjacent to each other on the t4 genome, are cotranscribed, and are translationally coupled. it has been suggested that translational coupling may play ... | 1999 | 10405357 |
| fluorescent oligonucleotide probes for clinical and environmental detection of acanthamoeba and the t4 18s rrna gene sequence type. | the first genus- and subgenus-specific fluorescent oligonucleotide probes for in situ staining of acanthamoeba are described. sequences of these phylogeny-based probes complement the 18s rrna and the gene encoding it (18s rdna). the genus-specific probe (gsp) is a fluorescein-labeled 22-mer specific for acanthamoeba as shown here by its hybridization to growing trophozoites of all 12 known acanthamoeba 18s rdna sequence types and by its failure to hybridize with amoebae of two other genera (hart ... | 1999 | 10405422 |
| evaluation of thyroid function in north indians with alopecia areata: response to intravenous injection of 100 micrograms thyrotropin releasing hormone (trh). | there is a lack of agreement on the overall prevalence of thyroid disease and thyroid function abnormalities in alopecia areata. only one study is available from the indian subcontinent. all patients with alopecia areata attending a dermatology outpatient clinic between 1983 and 1997 were screened for the presence of clinical thyroid disease. sixty-two consecutive patients during the year 1994 were evaluated in detail for thyroid functions by measuring t3, t4, tsh levels and testing for antithyr ... | 1999 | 10405476 |
| the efficacy of cryosurgical ablation of prostate cancer: the university of california, san francisco experience. | we analyze biopsy and prostate specific antigen (psa) results following cryosurgery for patients with clinically localized prostate cancer. | 1999 | 10411051 |
| influence of specific mutations on the thermal stability of the td group i intron in vitro and on its splicing efficiency in vivo: a comparative study. | group i introns constitute excellent systems for analyzing the relationship between rna tertiary folding and catalysis. within a hierarchical framework interpretation of rna folding, secondary structure motifs subtend rna three-dimensional (3d) architecture. thus, mutations in two-dimensional motifs are expected to have effects different from those disrupting 3d contacts. using uv spectroscopy, we have studied the influence of nucleotide substitutions, in both secondary and tertiary structure el ... | 1999 | 10411138 |
| effect of low-dose methyl prednisolone on serum cytokine levels following extracorporeal circulation. | the systemic inflammatory response to cardiopulmonary bypass (cpb) is associated with increased production of cytokines. this systemic inflammatory response characterized by the activation of interleukin-6 (il-6) and interleukin-8 (il-8) during and after cpb is well documented. a prospective, randomized, double-blind study was performed so as to understand the effects of low-dose methyl prednisolone sodium succinate (mpss) on the circulating levels of serum cytokines and clinical outcome. twenty ... | 1999 | 10411250 |
| regulation of thyroid hormone metabolism during fetal development. | compared with adults, plasma t3 concentrations in the human fetus are decreased, whereas levels of rt3 and the different iodothyronine sulfates, t4s, t3s, rt3s and 3,3'-t2s, are increased. the low t3 and high rt3 concentrations reflect the preponderance of inner ring versus outer ring deiodinase activity due to high type iii iodothyronine deiodinase (d3) expression in fetal tissues, such as liver and brain, the placenta, and perhaps also the uterus, in combination with still incomplete expressio ... | 1999 | 10411318 |
| local activation and inactivation of thyroid hormones: the deiodinase family. | tissue-specific activation and inactivation of ligands of nuclear receptors which belong to the steroid retinoid-thyroid hormone superfamily of transcription factors represents an important principle of development- and tissue-specific local modulation of hormone action. recently, several enzyme families have been identified which act as 'guardians of the gate' of ligand-activated transcription modulation. three monodeiodinase isoenzymes which are involved in activation the 'prohormone' l-thyrox ... | 1999 | 10411325 |
| [outcome after resection of extensive oropharyngeal carcinomas and defect coverage by microvascular anastomosis of a radialis flap]. | extensive tumors of the oropharynx require an open approach and plastic reconstruction for good oncologic and functional results. | 1999 | 10412135 |
| [intraoral cancer in the county of copenhagen]. | a retrospective study of patients treated for intra-oral squamous cell carcinoma in copenhagen county is reported. the material included 156 patients, 66 females and 90 males. age at diagnosis varied between 35 and 95 years with a mean of 65 years. mean age of females/males was 70/62 years. twelve therapeutic modalities were performed; surgery, radiotherapy, chemotherapy and different combinations of these. five year disease specific survival related to tumours' t-classification was 84% for t1, ... | 1999 | 10412321 |
| cluster versus conventional immunotherapy in patients allergic to dermatophagoides pteronyssinus: a controlled study of in vivo and in vitro parameters. | we designed a cluster schedule of immunotherapy for patients allergic to dermatophagoides pteronyssinus which showed good safety and clinical efficacy. here we compare the in vivo and in vitro changes with those of a conventional schedule in a controlled trial. sixty-three patients were randomized as follows: 29 were treated with the cluster schedule, 15 with a conventional schedule and 19 received no immunotherapy. a standardized extract was used. changes in in vivo parameters (skin prick test ... | 1999 | 10412676 |
| dermatophagoides pteronyssinus cluster immunotherapy. a controlled trial of safety and clinical efficacy. | we designed a cluster schedule of immunotherapy for patients allergic to dermatophagoides pteronyssinus to reach the maximal recommended dose in 7 weeks. we compared its safety and clinical efficacy with those of a conventional schedule in a controlled trial. sixty-three patients were randomized as follows: 29 were treated with the cluster schedule, 15 with a conventional schedule and 19 without immunotherapy. a standardized extract was used. clinical efficacy was measured by visual analog scale ... | 1999 | 10412677 |
| an evaluation of the carcinogenic potential of the herbicide alachlor to man. | chronic bioassays have revealed that alachlor caused nasal, thyroid, and stomach tumours in rats but was not carcinogenic in mice. significant increases in thyroid and stomach tumours were observed only at doses that exceeded the maximum tolerated dose (mtd). while nasal tumours were found at doses below the mtd, they were small and benign in nature. this publication describes the work undertaken by monsanto to understand the carcinogenic mode of action of alachlor in the rat and to investigate ... | 1999 | 10413243 |
| synthesis and nucleosome structure of dna containing a uv photoproduct at a specific site. | a strategy was developed to assemble nucleosomes specifically damaged at only one site and one structural orientation. the most prevalent uv photoproduct, a cis-syn cyclobutane thymine dimer (cs ctd), was chemically synthesized and incorporated into a 30 base oligonucleotide harboring the glucocorticoid hormone response element. this oligonucleotide was assembled into a 165 base pair double stranded dna molecule with nucleosome positioning elements on each side of the cs ctd-containing insert. p ... | 1999 | 10413526 |
| graves' disease during pregnancy--results of antithyroid drug therapy. | to assess the maternal and fetal outcome of pregnancies in thyrotoxic women. | 1999 | 10414160 |
| role of preoperative chemoradiation in the management of upper third thoracic esophageal squamous cell carcinoma. | the treatment of upper thoracic esophageal cancer remains challenging, and combined treatment is necessary to improve the outcome. we conducted preoperative chemoradiation therapy (crt) for potential t4 tumors located in the upper third esophagus and carried out a retrospective study to elucidate the role of preoperative crt. | 1999 | 10414703 |
| disruption of male sex hormones with regard to pesticides: pathophysiological and regulatory aspects. | several pesticides used as herbicides, insecticides and fungicides are known to be endocrine disrupting chemicals (edcs). in three pair-matched studies we found changes in sex hormone concentrations and t-lymphocytes in relation to acute and chronic pesticide exposure. after acute exposure, 1 day later the concentrations of testosterone and especially estradiol decreased. t4- and t8-lymphocytes slightly increased. effects of chronic occupational pesticide exposure were expressed by a higher leve ... | 1999 | 10414800 |
| sensitivity of thyroid gland growth to thyroid stimulating hormone (tsh) in rats treated with antithyroid drugs. | antithyroid drugs and phenobarbital (pb) have been shown to promote thyroid tumors in rats. it has been proposed that increased thyroid-stimulating hormone (tsh) mediates the thyroid tumor-promoting effect of antithyroid drugs and pb, and is increased because of decreased thyroxine (t4) concentration. however, pb is much less effective than antithyroid drugs at increasing tsh. it has been proposed that small increases in serum tsh produced by pb treatment is sufficient to promote thyroid tumors. ... | 1999 | 10416271 |
| gene 61.3 of bacteriophage t4 is the spackle gene. | the bacteriophage t4 e gene encodes lysozyme (e-lysozyme), which releases progeny phage after normal infection of escherichia coli cells. a mutation in the spackle gene suppresses the defect in e-lysozyme (emrich, 1968). the spackle gene was mapped between genes 41 and 61, but its precise location has not previously been determined. in the current study, we constructed an amber mutant of gene 61.3, amst14, by site-directed mutagenesis. the gene 61.3 mutant shares phenotypes with spackle mutants: ... | 1999 | 10417260 |
| the influence of supplements of selenite, selenate and selenium yeast on the selenium status of dairy heifers. | the aim of the study was to define possible differences between selenite, selenate and selenium yeast on various aspects of selenium status in growing cattle. twenty-four swedish red and white dairy heifers were fed no supplementary selenium for 6 months. the basic diet contained 0.026 mg selenium/kg feed dry matter (dm). after the depletion period the animals were divided into 4 groups; group i-iii received 2 mg additional selenium daily as sodium selenite, sodium selenate, and a selenium yeast ... | 1999 | 10418193 |
| new classification of stage iv squamous cell carcinoma of the oropharynx. | the recent progress in reconstructive surgery for the treatment of head and neck carcinomas has made it possible to radically resect cancers. however. the choice of treatment for oropharyngeal carcinoma is rather difficult. radical treatment sometimes results in severe complications, suggesting that some modes of treatment might reduce the quality of life. the 5-year survival rate of patients with stage iv oropharyngeal carcinoma is still very poor. it is necessary to re-classify stage iv squamo ... | 1999 | 10419040 |
| histopathological analysis of apoptosis, and expression of p53, bcl-2, bax, and ki-67 in laryngeal squamous cell carcinomas and dysplasia. | the growth of neoplasia is determined by the proliferation and loss of cells. the purpose of this study is to determine the frequency of apoptosis in laryngeal carcinomas and to examine its relationship to the pathological parameters, including ki-67 expression, and to expression of p53, bcl-2, and bax protein. the materials are 67 cases of laryngeal squamous cell carcinomas (sccs) and 22 cases of squamous dysplasia using biopsy and surgery specimens. apoptotic cells were determined by the modif ... | 1999 | 10419041 |
| [constitutive inhibition of dna degradation due to the enzyme recbcd in the radiation-resistant escherichia coli k-12 mutant gam(r)444]. | exonucleolytic degradation of [3]h-labeled dna was examined in partially purified fractions of lysates obtained from nonirradiated recbcd enzyme-containing cells of escherichia coli and in the radiation-resistant mutant gamr444. the degradative activity was shown to be lowered in these cells to the same extent as in the recbc mutant. the efficiency of plating of the mutant phage t4 2-, dna of which can be degraded by exonuclease v, was 400-fold higher on the strain gamr444 than on the wild-type ... | 1999 | 10420267 |
| surgical results of pancreaticoduodenectomy for carcinoma of the distal third of the stomach. | pancreaticoduodenectomy (pd) was performed as a radical operation on 10 patients who had stage iii or iv carcinoma of the distal third of the stomach which invaded the pancreas head (t4) or had level 3 lymph node metastasis. the surgical results of the pd were compared with those of 69 patients treated with subtotal gastrectomy (sg). although the postoperative morbidity was higher (70%) in the pd group than in the sg group (32%), no hospital death occurred. the overall postoperative survival pro ... | 1999 | 10421012 |
| tumor downstaging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer: the m. d. anderson cancer center experience. | to evaluate the rates of tumor downstaging after preoperative chemoradiation for locally advanced rectal cancer. | 1999 | 10421535 |
| [anesthesia in geriatric patients. the determination of physiological variables for cognitive function in geriatric patients after regional or general anesthesia]. | the aim of the present study was to show the influence of the parameters of gas exchange (arterial oxygen pressure pao2, arterial oxygen saturation sato2) and haemodynamics (arterial systolic and mean blood pressure rrs and map) on the restitution of cognitive functions in geriatric patients scheduled for elective hip arthroplasty. | 1999 | 10421921 |
| [thermostability of bacteriophage t4 fibritin and its deletion mutants]. | the thermal stability of a series of recently obtained mutants of fibritin from bacteriophage t4 (a superhelical fibrous homotrimer with parallel-packed subunits each containing 486 amino acid residues) progressively truncated from the subunit n-end was studied during incubation at 40-90 degrees c in the presence of a surfactant (2% sds). the mutant fibritins, g, b, c, and e, contained 443, 276, 231, and 120 amino acid residues, respectively. one more truncated mutant (fibritin s1, 108 amino aci ... | 1999 | 10422591 |
| neuropeptide y-induced contraction is mediated by neuropeptide y y2 and y4 receptors in the rat colon. | ascending and descending segments of the rat colon were studied to analyze their contractile responses to neuropeptide y and related peptides. these responses are (a) completely eliminated by tetrodotoxin (1 microm), (b) reduced to a variable extent (20 to 60%) by atropine (1 microm) and (c) not modified by indomethacin, diphenhydramine or methysergide. the order of potency of agonists for peptides related to neuropeptide y was as follows: human pancreatic polypeptide = rat pancreatic polypeptid ... | 1999 | 10422644 |
| positional preference of proline in alpha-helices. | conformational free energy calculations have been carried out for proline-containing alanine-based pentadecapeptides with the sequence ac-(ala)n-pro-(ala)m-nhme, where n + m = 14, to figure out the positional preference of proline in alpha-helices. the relative free energy of each peptide was calculated by subtracting the free energy of the extended conformation from that of the alpha-helical one, which is used here as a measure of preference. the highest propensity is found for the peptide with ... | 1999 | 10422838 |
| role of active site residues in the glycosylase step of t4 endonuclease v. computer simulation studies on ionization states. | t4 endonuclease v (endov) is a base excision repair enzyme that removes thymine dimers (td) from damaged dna. to elucidate the role of the active site residues in catalysis, their pk(a)'s were evaluated using the semimicroscopic version of the protein dipoles-langevin dipoles method (pdld/s). contributions of different effects to the pk(a) such as charge-charge interactions, conformational rearrangement, protein relaxation, and dna binding were analyzed in detail. charging of the active site res ... | 1999 | 10423235 |
| thermodynamics of stabilization of rna pseudoknots by cobalt(iii) hexaammine. | equilibrium unfolding (folding) studies reveal that the autoregulatory rna pseudoknots derived from the bacteriophage t2 and t4 gene 32 mrnas exhibit significant stabilization by increasing concentrations of divalent metal ions in solution. in this report, the apparent affinities of exchange inert trivalent co(nh(3))(3+)(6) have been determined, relative to divalent mg(2+), for the folded, partially folded (k(f)), and fully unfolded (k(u)) conformations of these molecules. a general nonspecific, ... | 1999 | 10423552 |
| effect of lung volume reduction surgery on bony thorax configuration in severe copd. | hyperinflation in patients with severe copd is associated with an increased anteroposterior (ap) rib cage diameter. we sought to determine whether bilateral lung volume reduction surgery (lvrs) affects bony thorax configuration. | 1999 | 10424500 |
| the carboxy-terminal domain initiates trimerization of bacteriophage t4 fibritin. | bacteriophage t4 fibritin is a triple-stranded, parallel, segmented alpha-helical coiled-coil protein. earlier we showed that the c-terminal globular domain (foldon) of fibritin is essential for correct trimerization and folding of the protein. we constructed the chimerical fusion protein w31 in which the fibritin foldon sequence is followed by the small globular non-alpha-helical protein gp31 of the t4 phage. we showed that the foldon is capable of trimerization in the absence of the coiled-coi ... | 1999 | 10424907 |
| [poems syndrome. report of a case]. | poems syndrome is a multisystem disorder with signs such as peripheral neuropathy, organomegaly, endocrinopathy, monoclonal protein, skin lesions, papilledema, and increased cerebrospinal fluid proteins, which can also evolve with renal and cardiac affection. it is considered a result of a plasma cell cyscrasia with the production of a monoclonal protein. a 46-year old man was seen as an outpatient referring progressive weakness of legs and arms, fever, impotence, inguinal and cervical lymphaden ... | 1999 | 10425826 |
| effect of nicotine on type 2 deiodinase activity in cultured rat glial cells. | intracellular generation of triiodothyronine (t3) from thyroxine (t4) by type 2 deiodinase (d2) in the mammalian brain, plays a key role in thyroid hormone action. the presence of d2 in rat astrocytes suggests the importance of glial cells in the regulation of intracellular t3 levels in the rat central nervous system (cns). to analyze further the factors that regulate d2 activity in the cns, we investigated the effects of nicotine and of mecamylamine, which inhibits the binding of nicotine with ... | 1999 | 10426574 |
| long-term treatment with bromocriptine of a plurihormonal pituitary adenoma secreting thyrotropin, growth hormone and prolactin. | a 48-year-old female presented with acromegaly, amenorrhea and hyperthyroidism associated with high serum free t4 levels and measurable tsh concentrations. the administration of ghrh induced significant increases in gh, prl and tsh. conversely, intravenous infusion of dopamine or oral administration of bromocriptine effectively inhibited gh, prl and tsh secretion. serum alpha-subunit levels were neither affected by ghrh, dopamine nor bromocriptine. transsphenoidal surgery was performed and immun ... | 1999 | 10426581 |
| a case of graves' disease associated with autoimmune hepatitis and mixed connective tissue disease. | the patient was a woman of forty-eight. liver dysfunction was pointed out at the age of forty-five. she was admitted to hospital because of her hyperthyroidism. her palmar skin was wet and her fingers were swollen like sausages. she had a diffuse and elastic hard goiter with a rough surface. the serum levels of free t3 (9.6 pg/ml) and free t4 (3.76 ng/dl) were high and that of tsh (0.11 microu/ml) was low. the activity of tsh-binding inhibitory immunoglobulin (tbii) was 89%. the uptake rate of 1 ... | 1999 | 10426583 |
| suppressive therapy with levothyroxine for euthyroid diffuse and nodular goiter. | in this study, 35 patients with euthyroid diffuse goiter and 35 patients with euthyroid nodular goiter were treated with levothyroxine (l-t4) for six months. the aim was to evaluate the efficacy of treatment on thyroid and nodule volumes and to evaluate the correlation between volume changes and thyroglobulin levels. serum thyroid hormones, tsh, thyroglobulin, thyroid and nodule volumes were measured at the initial visit and after 6 months. radioactive iodine uptakes of the thyroid gland were ev ... | 1999 | 10426591 |
| regulation of neuropeptide y release by neuropeptide y receptor ligands and calcium channel antagonists in hypothalamic slices. | neuropeptide y (npy) is an important regulator of energy balance in mammals through its orexigenic, antithermogenic, and insulin secretagogue actions. we investigated the regulation of endogenous npy release from rat hypothalamic slices by npy receptor ligands and calcium channel antagonists. high-potassium stimulation (60 mm) of the slices produced a calcium-dependent threefold increase in npy release above basal release. the y2 receptor agonists npy(13-36) and n-acetyl[leu28,leu31]npy(24-36), ... | 1999 | 10428060 |
| simultaneous interactions of bacteriophage t4 dna replication proteins gp59 and gp32 with single-stranded (ss) dna. co-modulation of ssdna binding activities in a dna helicase assembly intermediate. | the t4 gp59 protein is the major accessory protein of the phage's replicative dna helicase, gp41. gp59 helps load gp41 at dna replication forks by promoting its assembly onto single-stranded (ss) dna covered with cooperatively bound molecules of gp32, the t4 single-strand dna binding protein (ssb). a gp59-gp32-ssdna ternary complex is an obligatory intermediate in this helicase loading mechanism. here, we characterize the properties of gp59-gp32-ssdna complexes and reveal some of the biochemical ... | 1999 | 10428868 |
| persistent infantile hypothyroidism attributable to thyroxine-binding globulin deficiency. | an infant diagnosed with thyroid-binding globulin (tbg) deficiency after newborn screening demonstrated persistent elevation of thyroid-stimulating hormone (tsh) and abnormally low free thyroxine (ft4) levels. treatment with thyroxine (t4) normalized ft4 and tsh levels during the first 5 years of life, but withdrawal of t4 supplementation at that time was associated with return of hyperthyrotropinemic hypothyroidism. to our knowledge, this patient is the first reported case of tbg deficiency-ass ... | 1999 | 10429016 |
| [total pelvic exenteration and rectal cancer. apropos of 20 cases]. | the report of a series of 20 patients with the aim of trying to specify the implications of pelvic exenteration for rectal cancer. | 1999 | 10429298 |
| the impact of nutritional status on the prognoses of patients with advanced head and neck cancer. | malnutrition has been recognized as a poor prognostic indicator for cancer treatment-related morbidity and mortality in general, and it is reported to affect 30-50% of all patients with head and neck cancer. in this study, the correlation of nutritional status with 3-year survival was studied prospectively in 64 patients with t2-t4 carcinomas of the head and neck who were treated surgically with curative intent; the surgery was often followed by radiotherapy. | 1999 | 10430262 |
| radical surgery for gallbladder cancer. results of the french surgical association survey. | gallbladder carcinoma is a highly lethal disease. the advantages of radical surgery remain controversial. the authors' objective was to evaluate the effectiveness of an aggressive approach to gallbladder carcinoma on long-term survival. | 1999 | 10430296 |
| genetic analysis of the bacteriophage t4-encoded cochaperonin gp31. | previous genetic and biochemical analyses have established that the bacteriophage t4-encoded gp31 is a cochaperonin that interacts with escherichia coli's groel to ensure the timely and accurate folding of gp23, the bacteriophage-encoded major capsid protein. the heptameric gp31 cochaperonin, like the e. coli groes cochaperonin, interacts with groel primarily through its unstructured mobile loop segment. upon binding to groel, the mobile loop adopts a structured, beta-hairpin turn. in this artic ... | 1999 | 10430575 |
| structural basis of the conversion of t4 lysozyme into a transglycosidase by reengineering the active site. | in contrast to hen egg-white lysozyme, which retains the beta-configuration of the substrate in the product, t4 lysozyme (t4l) is an inverting glycosidase. the substitution thr-26 --> his, however, converts t4l from an inverting to a retaining enzyme. it is shown here that the thr-26 --> his mutant is also a transglycosidase. indeed, the transglycosylation reaction can be more effective than hydrolysis. in contrast, wild-type t4l has no detectable transglycosidase activity. the results support t ... | 1999 | 10430876 |
| laparoscopic evaluation of the risk of locoregional recurrence after radical surgery for gastric cancer. | we studied the diagnostic utility of laparoscopy in patients who underwent absolute radical surgery (r0) for gastric adenocarcinoma and who were at risk for locoregional recurrence. risk was considered to exist in patients with t3-t4 stage tumors (iuac tnm classification) that invaded the serosa or affect nearby organs. these patients are candidates for clinical trials involving multimodal therapies, especially with neoadjuvant or intraperitoneal chemotherapy. | 1999 | 10431090 |
| interaction of beta-l-adenosine-5'-triphosphate (l-atp) with human deoxycytidine kinase, human dna primase and t4 dna ligase: does the chance direct enzymatic enantioselectivity? | we demonstrate that l-atp: 1) as well as its natural d-enantiomer, acts as a phosphate donor in the reaction catalysed by human deoxycytidine kinase; 2) inhibits human dna-primase and the atp-dependent t4 dna ligase. thus, the lack of enantioselectivity of the enzymes is more frequent than it was believed a few years ago and we suggest that it would depend on chance more than on an evolutionary strategy. | 1999 | 10432697 |
| pretherapeutic laparoscopic staging in advanced gastric carcinoma. | direct visualization of the abdominal cavity by laparoscopy prior to multimodal treatment may be capable of improving the diagnostic precision of gastric cancer staging. the aim of this study was to evaluate whether diagnostic laparoscopy can influence treatment strategies in gastric cancer staged t3 and t4 by preoperative diagnostic tests. | 1999 | 10433041 |
| escape from the acute wolff-chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. | in 1948, wolff and chaikoff reported that organic binding of iodide in the thyroid was decreased when plasma iodide levels were elevated (acute wolff-chaikoff effect), and that adaptation or escape from the acute effect occurred in approximately 2 days, in the presence of continued high plasma iodide concentrations. we later demonstrated that the escape is attributable to a decrease in iodide transport into the thyroid, lowering the intrathyroidal iodine content below a critical inhibitory thres ... | 1999 | 10433193 |
| cloning and characterization of type iii iodothyronine deiodinase from the fish oreochromis niloticus. | type iii iodothyronine deiodinase (d3) catalyzes the inner ring deiodination (ird) of t4 and t3 to the inactive metabolites rt3 and 3,3'-diiodothyronine (3,3'-t2), respectively. here we describe the cloning and characterization of complementary dna (cdna) coding for d3 in fish (oreochromis niloticus, tilapia). this cdna contains 1478 nucleotides and codes for a protein of 267 amino acids, including a putative selenocysteine (sec) residue, encoded by a tga triplet, at position 131. the deduced am ... | 1999 | 10433225 |
| mandibular articular disk position changes during herbst treatment: a prospective longitudinal mri study. | the aim of this prospective longitudinal study of 15 consecutively treated class ii malocclusions was to assess any possible changes in the relative position of the articular disk to the condyle during different phases of herbst therapy. using a disk position index, parasagittal mris (central, medial and lateral slices) of the right and left tmj were analyzed at five occasions: before herbst treatment (t1), at start of treatment when the appliance was placed (t2), after 6 weeks of treatment (t3) ... | 1999 | 10434095 |
| [the hyoid bone in reconstructive laryngeal and cervical surgery]. | the hyoid bone, with its complex system of connected muscles, ligaments and membranes, provides a highly resistant anchor point in all cases of larynx tumour surgery requiring a "pexy" to reconstruct the upper respiratory tract. this bone can also be important in reconstructive cervical surgery employing myocutaneous flaps, especially after extensive tissue removal, such as in locally advanced larynx tumours (primary t4 lesions or recurrences after partial or subtotal operations) and some primar ... | 1999 | 10434457 |
| [intramedullary metastasis of small cell lung cancer]. | a 64-year-old man complaining of hoarseness received a diagnosis of small cell lung cancer (t4 n3 m1, stage iv) in may 1997. he responded well to chemotherapy and radiotherapy, and afterward underwent brain irradiation for prophylactic purposes. however, on nov. 27 the patient experienced lumbar pain and numbness in his left leg. and was admitted to our hospital on dec. 2 because his symptoms deteriorated to palsy of the left leg. brain computed tomographic scans and lumbar magnetic resonance im ... | 1999 | 10434549 |
| [effects of a 5-day fast on clinical laboratory data from patients with rheumatoid arthritis]. | there have been few studies on the effects of a fast on clinical laboratory data in japanese. we studied twelve women with rheumatoid arthritis who were not taking any medicine and stayed in the koda hospital for a diet which lasted 55 days. they basically took a 1200 kcal vegan diet and undertook a 3-5-day fast three times. the clinical laboratory data obtained before and after the second fast (day 27-day 31) were compared. average body weight decreased by 1.5 kg. there were no changes in crp. ... | 1999 | 10434574 |
| [monitoring of treatment in thyroid diseases]. | the effectiveness of antithyroid drug treatment of graves' hyperthyroidism is documented by measuring initially free t4 and free t3 and later free t4, free t3 and tsh. an elevated titer of the graves'-specific thyroid stimulating antibodies is not usually rechecked before the end of the antithyroid drug therapy. thyroxine treatment of primary hypothyroidism is controlled by tsh measurements. in patients in whom tsh levels might be affected by drugs or nonthyroid diseases, free t4 is measured in ... | 1999 | 10434779 |
| diagnosis and treatment of the solitary thyroid nodule. results of a european survey. | the optimum diagnostic and therapeutic strategy for the euthyroid patient with a solitary thyroid nodule is still a matter of debate. the aim was to assess the attitudes towards management of such patients in clinical centres throughout europe by means of a questionnaire. | 1999 | 10435062 |
| a third decade's experience with the gastric pull-up operation for hypopharyngeal carcinoma: changing patterns of use. | gastric transposition has been used extensively in this department since 1965 for reconstruction following pharyngolaryngoesophagectomy (plo). a previous report by harrison and thompson in 1986 detailed our experience with 101 cases dating back to 1965. here we review our experience between 1986-1996. medical records of 41 cases were examined. the primary site and stage of tumour and associated lymph nodes, patient demographics, complications, in-patient mortality and survival as demonstrated by ... | 1999 | 10435132 |
| prognostic implications of response to preoperative infusional chemoradiation in locally advanced rectal cancer. | to evaluate the influence of response to preoperative infusional chemoradiation on outcome parameters among patients with locally advanced rectal cancer. | 1999 | 10435807 |
| primary hypothyroidism-associated tsh-secreting pituitary adenoma/hyperplasia presenting as a bleeding nasal mass and extremely elevated tsh level. | a 41-year-old male with primary hypothyroidism and a huge tsh-secreting pituitary tumor presented with a bleeding nasal mass that was initially misdiagnosed as a paraganglioma. other unique features of the case include lack of complaints related to hypothyroidism, an extremely elevated tsh level of 3474 mu/l, and a low prolactin level. the presence of primary hypothyroidism made differentiating tsh-secreting pituitary adenoma from secondary thyrotroph hyperplasia difficult. a low molar ratio of ... | 1999 | 10435850 |
| a comparison of preconstituted, fixed combinations of low-dose glyburide plus metformin versus high-dose glyburide alone in the treatment of type 2 diabetic patients. | in the present study we assessed and compared the effectiveness and safety of preconstituted, fixed, combinations of low-dose glyburide plus metformin with higher-dose glyburide monotherapy in patients with type 2 diabetes. this randomized, double-blind, cross-over study comprised 40 patients. after a 30-day run-in period of dietary treatment, patients received combined glyburide (5, 7.5 or 10 mg/day) and metformin (800, 1,200 or 1,600 mg/day) as preconstitued, fixed combinations, or glyburide a ... | 1999 | 10436254 |
| [incidence of oral cancer profile at a general hospital in säo paulo]. | cancer of the oral cavity are 4% of all cancers, being in 8th place in males and 11th in females. the world incidence in male sex is 7.9:100,000 and 2.2:100,000 in females. squamous cell carcinoma is the most frequent, corresponding to 90-95% of the cases and tongue, lips and floor of the mouth are the most common sites. fifty-four patients were surgically treated for cancer of the oral cavity in a general hospital in são paulo, during last ten years. it occurs more in males (81.5%), the age ran ... | 1998 | 10436641 |
| inhibitory effects of cyproheptadine on pituitary-thyroid axis and pancreatic beta cells in rats. | to study the influences of cyproheptadine (cyp) on the endocrine functions of pituitary-thyroid axis and pancreatic beta cells in rats. | 1998 | 10437145 |