| experimental increase in accommodative potential after neodymium: yttrium-aluminum-garnet laser photodisruption of paired cadaver lenses. | loss of lens elasticity is one of several proposed mechanisms responsible for the decline in accommodation with age and is the most accepted explanation for presbyopia. we wish to confirm the lens elasticity premise and attempt to experimentally reverse the age-dependent loss of accommodative potential as measured by polar strain. | 2001 | 11713090 |
| an elevated amniotic fluid matrix metalloproteinase-8 level at the time of mid-trimester genetic amniocentesis is a risk factor for spontaneous preterm delivery. | strong evidence implicates chronic intra-amniotic inflammation in the etiology of mid-trimester abortion and spontaneous preterm delivery. the purpose of this study was to determine if concentrations of amniotic fluid matrix metalloproteinase-8, and cytokines such as interleukin-6 and angiogenin can identify patients at risk for spontaneous preterm delivery in patients undergoing mid-trimester amniocentesis. | 2001 | 11717651 |
| bacteriocin susceptibility of gardnerella vaginalis and its relationship to biotype, genotype, and metronidazole susceptibility. | our purpose was to investigate the bacteriocin susceptibility of gardnerella vaginalis and its relationship to biotype, genotype, and resistance to metronidazole. | 2001 | 11717655 |
| magnetic resonance imaging of ethyl-nitrosourea-induced rat gliomas: a model for experimental therapeutics of low-grade gliomas. | human low-grade gliomas represent a population of brain tumors that remain a therapeutic challenge. preclinical evaluation of agents, to test their preventive or therapeutic efficacy in these tumors, requires the use of animal models. spontaneous gliomas develop in models of chemically induced carcinogenesis, such as in the transplacental n-ethyl-n-nitrosourea (enu) rat model. however, without the ability to detect initial tumor formation, multiplicity or to measure growth rates, it is difficult ... | 2001 | 11718257 |
| guillain barré syndrome. | guillain barré syndrome is one of the best examples of a post infectious immune disease and offers insights into the mechanism of tissue damage in other more common autoimmune diseases. controlled epidemiological studies have linked it to infection with campylobacter jejuni in addition to other viruses including cytomegalovirus and epstein barr virus. the syndrome includes several pathological subtypes, of which the most common is a multifocal demyelinating disorder of the peripheral nerves in c ... | 2001 | 11724912 |
| effects of a brief, theory-based std-prevention program for female college students. | to evaluate a brief, theoretically guided sexually transmitted disease (std) risk-reduction intervention tailored to college-aged women. | 2001 | 11728891 |
| flk-1 specific kinase inhibitor (su5416) inhibited the growth of gs-9l glioma in rat brain and prolonged the survival. | accumulating evidences suggest that tumor growth and metastasis depend on angiogenesis. at present, plenty of efforts are made to discover a chemical compound that specifically inhibits tumor angiogenesis either by reducing pro-angiogenic factor or increasing anti-angiogenic factors. | 2001 | 11733657 |
| highly active antiretroviral-treated hiv-infected children show fat distribution changes even in absence of lipodystrophy. | combined use of dual-energy x-ray absorptiometry (dxa) and magnetic resonance imaging (mri) allows a precise estimate of regional body composition and intra-abdominal adipose tissue (iat). data on body composition in hiv-infected children (hiv+) receiving highly active antiretroviral therapy (haart) with (ld+) and without (ld-) lipodystrophy are lacking. | 2001 | 11740192 |
| differentiation of rat neural tissue in a serum-free embryo culture model followed by in vivo transplantation. | to analyze neural tissue differentiation in a unique, chemically-defined in vitro culture model of gastrulating rat embryo proper by use of transmission electron microscopy (tem), proliferating cell nuclear antigen (pcna) expression, and in vivo transplantation after a 2-week culture in serum-free or serum-supplemented media. influence of protein-free medium unfavorable for differentiation of neural tissue in vitro was compared with favorable serum-free media enriched with transferrin or albumin ... | 2001 | 11740842 |
| chronic ethanol and nicotine interaction on rat tissue antioxidant defense system. | ethanol consumption and cigarette smoking are common in societies worldwide and have been identified as injurious to human health. this study was undertaken to examine the interactive effects of chronic ethanol and nicotine consumption on the antioxidant defense system in different tissues of rat. male fisher-344 rats were divided into four groups of five animals each and treated for 6.5 weeks as follows: (1) control rats were administered normal saline orally; (2) ethanol (20% [wt./vol.]) was g ... | 2001 | 11747978 |
| rare hras1 alleles are a risk factor for the development of brain tumors. | the highly polymorphic hras1 minisatellite locus, located 1 kilobase downstream from the h-ras1 gene, has been associated with increased susceptibility to a variety of cancers. microsatellite instability (mi), another molecular abnormality observed in human neoplasms, most likely reflects an increased mutation rate and also is thought to underlie cancer predisposition. the purpose of this study was to investigate the association between rare hras1 alleles and brain tumors and to correlate the hr ... | 2001 | 11753967 |
| npc1: complete genomic sequence, mutation analysis, and characterization of haplotypes. | niemann-pick type c disease (np-c) is a rare, autosomal recessive lipid storage disorder. at least 96% of all np-c patients link to npc1 which encodes for a lysosomally-targeted protein. we describe the complete genomic sequence of 57,052 kb corresponding to the transcribed region of human npc1 including several exonic and intronic single nucleotide polymorphisms (snps). sequencing of all exons, splice sites, and the promoter region of npc1 in 12 unrelated caucasian np-c patients revealed nine n ... | 2002 | 11754101 |
| a specific force deficit exists in skeletal muscle after partial denervation. | skeletal muscle demonstrates a specific force deficit after repair of injured peripheral nerves, microneurovascular muscle transfer, and normal aging. because atrophy cannot account for deficits in specific force, other, unknown, mechanisms are responsible for the resulting muscle contractile dysfunction under these circumstances. we tested the hypothesis that a subpopulation of denervated fibers is partially or completely responsible for the specific force deficit after partial denervation of t ... | 2002 | 11754182 |
| frequent detection of t cells with mutations of the hypoxanthine-guanine phosphoribosyl transferase gene in patients with paroxysmal nocturnal hemoglobinuria. | acquired mutations of the pig-a gene result in the hemolysis characteristic of paroxysmal nocturnal hemoglobinuria (pnh). although the etiology of the mutation(s) is unclear, mutable conditions have been suggested by the coexistence of multiple clones with different mutations of pig-a and by the appearance of leukemic clones in patients with pnh. this study sought to test this hypothesis by examining the frequency of hypoxanthine-guanine phosphoribosyl transferase (hprt) gene mutations, identifi ... | 2002 | 11756148 |
| adaptive cytoprotection against acetic acid induced colonic injury in rats. | the phenomenon of prostaglandin dependent adaptive cytoprotection has been well established in the stomach and duodenum but not in the colon. this study investigated whether it also occurs in the colon. | 2001 | 11760900 |
| ethical problems in research on risky behaviors and risky populations. | the articles by brooks-gunn, fisher, hoagwood, liss and scott-jones (all in this issue) present a panoply of real-world ethical issues in conducting scientific research on risky behaviors of children, adolescents, and their parents, particularly those from vulnerable populations. the universal, ethical principles of beneficence, justice, and respect for others are always applicable, but they do not resolve issues of child assent, parental consent, legal reporting requirements for illegal behavio ... | 1994 | 11654928 |
| [changes in biochemical characteristics of collagen and the cartilage water in osteoarthritis]. | the stability of collagen molecules and moisture capacity of human normal and osteoarthrotic (oa) cartilage were studied before and after extraction of glycosaminoglycans (gag) by 4m guanidinum chloride. the content and nature of water were determined by fisher titration, dsc and analysis of sorbtion-desorbtion processes of water vapour in cartilage. the stability of collagen molecules was determined by the degree of enzymatic hydrolysis: collagenase, pronase and pepsin. it was found that weaken ... | 2001 | 11766260 |
| mucin secretion in the rat tracheal epithelial cells by epidermal growth factor and pseudomonas aeruginosa extracts. | hypersecretion of mucin due to goblet cell hyperplasia is frequently encountered in many chronic airway diseases, such as chronic bronchitis, bronchiectasis, bronchial asthma and cystic fibrosis. even in normal individuals, viral infection or bacterial pneumonia frequently provoke huge amounts of bronchial secretions which may cause airway obstruction. the production of mucin was regulated by epidermal growth factor (egf) in vitro. to know whether this egf system regulates mucin secretion in viv ... | 2001 | 11769575 |
| standardization of the comet assay technique on frtl5 cells. | the comet assay is a sensitive and rapid method for dna strand break detection in individual cells. the principle of break detection, using either the alkaline or neutral version of the assay, makes it a good technique for studying both double and single strand dna breaks. furthermore, the possibility of following dna damage at different time moments also makes it possible to investigate the cell repair mechanisms. this explains why in the last few years there has been a tremendous increase in t ... | 2001 | 11776984 |
| paired tumor marker of soluble e-selectin and its ligand sialyl lewis a in colorectal cancer. | better diagnosis of metastatic disease has been pursued by oncologists: however, many of the tumor markers have been still controversial. our purpose was to estimate the usefulness of soluble e-selectin and its ligand sialyl lewis a for more accurate diagnosis as a combined tumor marker for metastases in colorectal cancer. | 2001 | 11777210 |
| allogeneic bone marrow transplantation at wilford hall u.s. air force medical center: 1987-1999. | wilford hall medical center (whmc), at lackland air force base in san antonio, texas, is the only center within the u.s. department of defense at which allogeneic bone marrow transplantation (bmt) is performed. from the inception of the bmt program in 1987 through february 1999, 286 military health care beneficiaries have undergone human leukocyte antigen-matched related donor allogeneic bone marrow transplantation for hematologic disorders. we conducted a retrospective chart review to analyze t ... | 2001 | 11778401 |
| miller fisher syndrome: toward a more comprehensive understanding. | to review recent knowledge on the clinical features, pathology and pathophysiology, diagnosis and treatment of miller fisher syndrome (mfs). | 2001 | 11780304 |
| life cycle of genarchopsis goppo (trematoda: derogenidae) from nara, japan. | a cystophorous cercaria obtained from semisulcospira libertina (gould) from tobihino, nara, honshu, japan, was used to experimentally infect a freshwater goby rhinogobius sp. or via the copepods mesocyclops leuckarti (claus), thermocyclops hyalinus (rehberg), and eucyclops sarrulatus (fisher). it was shown to grow into genarchopsis goppo ozaki, 1925. the parasite was found to occur as a natural infection in the stomach of rhinogobius sp. or and odontobutis obscura (temminck and schlegel) from to ... | 2001 | 11780829 |
| [risk of deep infection in first-intention total hip replacement. evaluation concerning a continuous series of 790 cases]. | deep infections of the operative site is a rare but serious complication of first intention total hip arthroplasties. french data on infections are sparse. we studied the incidence, characteristics and potential risk factors for these infections in a consecutive series of 790 total hip arthroplasties performed as first intention implantations in a university hospital in france. | 2001 | 11791394 |
| apoptosis in skeletal muscle with aging. | sarcopenia may be partly due to a loss in total fiber number by apoptosis. we have investigated age-related alterations in the mitochondria-mediated pathway leading to apoptosis in the gastrocnemius muscle from 6-mo-old and 24-mo-old male fisher 344 rats. apoptosis (mono- and oligonucleosome fragmentation) in the gastrocnemius muscle was increased by 50% in the old rats compared with the adult animals. furthermore, there was a significant correlation between cytosolic cytochrome c and caspase-3 ... | 2002 | 11792662 |
| age-dependent declines in proteasome activity in the heart. | the proteasome is a major intracellular proteolytic system involved in the removal of oxidized and ubiquitinated protein and the induction of certain stress response pathways. in this study, age-dependent alterations in proteasome function were investigated to gain insight into potential factors which contribute to increased susceptibility to various forms of heart disease during aging. proteasome activity in cellular extracts prepared from fisher 344 rat hearts was found to decrease with age. t ... | 2002 | 11795886 |
| muscarinic cholinergic receptor subtypes in the hippocampus of aged rats. | in spite of the suggestion of impaired muscarinic function in adult-onset cognitive disorders, data on the expression of muscarinic receptors in the hippocampus as a function of age are inconsistent. one reason may be that the majority of investigations were unable to differentiate the five brain muscarinic receptors subtypes. in this study, using a protocol based on a combination of both kinetic and equilibrium binding approaches, we have assessed the expression and the density of m1-m5 muscari ... | 2002 | 11796137 |
| cholinergic innervation of pial arteries in senescent rats: an immunohistochemical study. | perivascular acetylcholine (ach)-immunoreactive nerve fibres were demonstrated in basilar and middle cerebral arteries, in pial arteries and arterioles and in intracerebral arteries of male fisher 344 rats of 6 months (young), 15 months (adult) and 22 months (senescent). analysis included whole mounts of basilar and middle cerebral arteries, of pial arteries and sections of brain including pia-arachnoid membrane to demonstrate the localization of nerve fibres throughout the wall of pial and of i ... | 2002 | 11796138 |
| efficiency of protection of guinea pigs against infection with bacillus anthracis spores by passive immunization. | the efficacy of passive immunization as a postexposure prophylactic measure for treatment of guinea pigs intranasally infected with bacillus anthracis spores was evaluated. antisera directed either against the lethal toxin components (pa or lf) or against a toxinogenic strain (sterne) were used for this evaluation. all antisera exhibited high enzyme-linked immunosorbent assay titers against the corresponding antigens, high titers of neutralization of cytotoxicity activity in an in vitro mouse ma ... | 2002 | 11796581 |
| detection of tumorigenesis in rat bladders with optical coherence tomography. | optical coherence tomography (oct) is a novel technique that enables noninvasive cross-sectional imaging of biological tissues. because of its high resolution (approximately 10 microm), superior dynamic range (140 db in our case) and up to 2-3 mm penetration depth, oct is potentially useful for noninvasive screening of superficial lesions. bladder cancer arises within the transitional epithelium. despite the ability to visualize the epithelium via cystoscopy, it is often difficult to detect earl ... | 2001 | 11797946 |
| synergism of rad and cyclosporin a in prevention of acute rat corneal allograft rejection. | the novel immunosuppressant rad, 40-0-(2-hydroxy-ethyl)-rapamycin, has synergistic effects with cyclosporin a. the aim of this study was to evaluate the combined effect of rad and cyclosporin a in the prevention of acute allograft rejection after murine corneal transplantation. | 2002 | 11805513 |
| overexpression of the v3 variant of versican alters arterial smooth muscle cell adhesion, migration, and proliferation in vitro. | versican is an extracellular matrix proteoglycan produced by many cells. although versican is generally known as a large chondroitin sulfate proteoglycan (cspg), the smallest splice variant, v3, consists only of the amino- and carboxy-terminal globular domains and is therefore predicted to be a small glycoprotein, lacking cs chains. the large size, negative charge, and ability of versican variants to form pericellular coats with hyaluronan are responsible for many of its effects. v3, lacking the ... | 2002 | 11807809 |
| predictive factors in the evolution of neural deficit in tuberculosis of the spine. | this study was conducted to determine the factors involved in predicting the onset of paraplegia in tuberculosis of the spine. a cross-sectional, case control review of 85 cases of spinal tuberculosis was conducted at the national tuberculosis centre in kuala lumpur. sixty-nine of these cases were normal neurologically, whilst 16 cases experienced neural deficit. the data was analysed using backward logistic regression and fishers exact probability test. the factors studied included symptoms and ... | 2001 | 11814249 |
| vascular endothelial growth factor and basic fibroblast growth factor in patients with squamous cell oesophageal cancer. | it is suggested that vascular endothelial growth factor (vegf) and basic fibroblast growth factor (bfgf) play an important role in tumor-induced angiogenesis. the purpose of this study was to estimate the correlation between vegf and bfgf levels and tumor pathological status according to ptnm classification in patients with squamous cell oesophageal cancer. a group of 25 healthy controls and 32 consecutive patients with oesophageal cancer were included in this study. serum vegf and bfgf levels w ... | 2001 | 11820569 |
| ischemia-responsive protein (irp94) is up-regulated by endoplasmic reticulum stress. | the expression of the ischemia-responsive protein (irp94) was enhanced by endoplasmic reticulum (er) stress inducing drugs such as brefeldin a (bfa), calcium ionophor a23187, dithiothreitol (dtt) and tunicamycin in fisher rat thyroid epithelial cell line (frtl-5 cells). in particular, irp94 mrna expression was increased dose dependently by tunicamycin, and there was increased irp94 expression when the cells were incubated with the thyroid-stimulating hormone (tsh) together. | 2001 | 11837675 |
| effects of low-protein diet on the baroreflex and bezold-jarisch reflex in conscious rats. | the present study evaluated the effects of a low-protein diet (lp, 6% protein) on cardiovascular reflexes of male fisher rats. three experimental groups, and their respective controls (15% protein), were used: (1) baroreceptor reflex (bar); (2) bezold-jarisch reflex (bjr); and (3) prazosin treated. dietary restriction began after weaning (three weeks) and lasted for a period of five weeks, after which animals were subjected to the experimental protocols. the bar group was evaluated through injec ... | 2001 | 11842885 |
| traces of early eurasians in the mansi of northwest siberia revealed by mitochondrial dna analysis. | the mitochondrial dna (mtdna) of 98 mansi, an ancient group (formerly known as "vogul") of uralic-speaking fishers and hunters on the eastern slope of the northern ural mountains, were analyzed for sequence variants by restriction fragment--length polymorphism analysis, control-region sequencing, and sequencing of additional informative sites in the coding region. although 63.3% of the mtdna detected in the mansi falls into western eurasian lineages (e.g., haplogroups uk, tj, and hv), the remain ... | 2002 | 11845409 |
| early application of met-rantes ameliorates chronic allograft nephropathy. | initial insults to kidney allografts, characterized by infiltration of mononuclear inflammatory cells, contribute to chronic allograft nephropathy. chemokines such as rantes (regulated upon activation, normal t cell expressed) are thought to be responsible for the recruitment and activation of infiltrating cells. the present study investigated whether early application of met-rantes, a chemokine receptor antagonist that blocks the effects of rantes, can protect renal allografts from long-term de ... | 2002 | 11849411 |
| lecithinized superoxide dismutase reduces cold ischemia-induced chronic allograft dysfunction. | chronic renal allograft failure (caf) is influenced by both allo-dependent and independent factors and is a major cause of graft loss in clinical renal transplantation. we evaluated a novel membrane-bound free radical scavenger, lecithinized superoxide dismutase (lec-sod), to determine its potential in limiting the harmful effects of ischemia/reperfusion injury on caf. | 2002 | 11849471 |
| structure of campylobacter jejuni lipopolysaccharides determines antiganglioside specificity and clinical features of guillain-barré and miller fisher patients. | ganglioside mimicry in the lipopolysaccharide (lps) fraction of campylobacter jejuni isolated from guillain-barré syndrome (gbs) and miller fisher syndrome (mfs) patients was compared with isolates from patients with an uncomplicated enteritis. the antibody response to c. jejuni lps and gangliosides in neuropathy patients and controls was compared as well. lps from gbs and mfs-associated isolates more frequently contained ganglioside-like epitopes compared to control isolates. almost all neuropa ... | 2002 | 11854201 |
| apoptosis and cd8 and cd54 cell expression in rat small bowel transplantation. | the importance of activated cd8 cells expressing il-2r in small bowel and other organ rejection has been reported. some authors even consider that a positive correlation might be demonstrated between the number of apoptotic enterocytes and the degree of graft rejection. in addition, moderate to intense activation of endothelial molecules in small bowel allograft in rats has been reported in chronic rejection. the aim of the present paper is to ascertain, in a heterotopic small bowel transplantat ... | 2002 | 11855915 |
| infectious origins of, and molecular mimicry in, guillain-barré and fisher syndromes. | guillain-barré syndrome (gbs), characterised by limb weakness and areflexia, is the prototype of postinfectious autoimmune diseases, and campylobacter jejuni is the most frequent antecedent pathogen. gbs subsequent to c jejuni enteritis is associated with a severe, pure motor axonal variant and igg antibodies against gm1, gm1b, gd1a, or galnac-gdla, gangliosides expressed in human peripheral nerves. lipopolysaccharides of c jejuni isolated from gbs patients have ganglioside-like epitopes. cytome ... | 2001 | 11871407 |
| enhanced growth of colorectal aberrant crypt foci in fasted/refed rats involves changes in tgfbeta1 and p21cip expressions. | we previously demonstrated that fasting/refeeding enhances the initiation phase of liver and colorectal carcinogenesis in rats. the present study was undertaken to establish whether cycles of fasting/refeeding carried out during the promotion phase of carcinogenesis may also affect the formation of aberrant crypt foci (acf), preneoplastic lesions induced in the colon by azoxymethane (aom). we were also interested in studying whether this effect might be mediated by changes in the proliferation, ... | 2002 | 11872640 |
| s100a4 (p9ka) protein in colon carcinoma and liver metastases: association with carcinoma cells and t-lymphocytes. | the presence of the ef-hand-calcium-binding protein s100a4 in the carcinoma cells of the primary tumour is associated with a shorter survival time of a group of breast cancer patients. in colon cancer, primary tumours as well as metastases to the liver can be studied. here we show, using quantitative pcr applied to rna from 24 normal colon, four liver tissues, 24 colon carcinoma specimens, and 24 livers containing colonic carcinoma metastases, that the level of s100a4 mrna was significantly high ... | 2002 | 11875708 |
| rat strain differences in nicotine self-administration using an unlimited access paradigm. | an effective animal model for elucidating the neurobiological basis of human smoking should simulate important aspects of this behavior. therefore, a 23 h unlimited access nicotine self-administration model was used to compare inbred lewis rats, which have a propensity to self-administer drugs of abuse, to inbred fisher 344 rats and to the outbred holtzman strain. using this unlimited access model, 88.8% of lewis vs. 57.1% of holtzman rats achieved maintenance self-administration at a fixed rati ... | 2002 | 11879790 |
| prognostic value of p53 overexpression in t1g3 bladder tumors treated with bacillus calmette-guérin therapy. | to evaluate the correlation between the overexpression of mutant protein p53 and disease recurrence and progression in patients treated with bacillus calmette-guérin (bcg) intravesical therapy for t1g3 bladder cancer. | 2002 | 11880082 |
| role of oxidative dna damage caused by carbon tetrachloride-induced liver injury -- enhancement of meiq-induced glutathione s-transferase placental form-positive foci in rats. | the strong association between chronic inflammation and development of cancer is well-established in chronic inflammatory states. nitric oxide (no) is generated by inflammatory cytokines due to the action of inducible nitric oxide (inos), oxidizing dna to form 8-hydroxy-2'-deoxyguanosine (8-ohdg) adducts, a major species of oxidative dna damage. in the present study, we investigated the enhancing effect of carbon tetrachloride, a typical hepatotoxic chemical, on rat 2-amino-3,8-dimethylimidazo[4 ... | 2002 | 11880177 |
| relationships of cortisol, perceived stress, genitourinary infections, and fetal fibronectin to gestational age at birth. | the authors investigated the role of stress and cortisol with patients having preterm labor (ptl) and preterm birth (ptb). the relationships of maternal cortisol, perceived stress, fetal fibronectin (ffn), and genitourinary infections to ptl and ptb were studied. a prospective, longitudinal, observational study (n = 78) was conducted in a private practice in central texas. subjects had 4 blood draws for cortisol measurements grouped by 15-19, 20-22, 23-26, 27-30, and 31-35 weeks of gestation. su ... | 2001 | 11885913 |
| expression of growth arrest-specific gene 6 and its receptors in a rat model of chronic renal transplant rejection. | growth arrest-specific gene 6 (gas6) is involved in a number of cell functions that include proliferation of vascular smooth muscle cells and mesangial cells. the proliferation of these cells is a feature of chronic rejection (cr) after kidney transplantation. therefore, we examined the gene expression of gas6 and its receptors rse, axl, and mer in a rat model of cr. | 2002 | 11889449 |
| molecular analysis of mitochondrial dna mutations from bleomycin-treated rats. | in our previous studies, we have shown the mutagenicity of bleomycin (blm) at the nuclear hprt locus. in the present study we have analyzed mutagenic effects of blm in mitochondrial dna (mtdna) using short extension-pcr (se-pcr) method for detection of low-copy deletions. fisher 344 rats were treated with a single dose of blm and total dna preparations from splenic lymphocytes were processed in se-pcr assay. spontaneous deletions were typically flanked by direct repeats (78.5%), while the in blm ... | 2002 | 11890929 |
| gnrh analog, leuprorelin acetate, promotes regeneration of rat spermatogenesis after severe chemical damage. | future fertility is a major concern for cancer patients who undergo intensive chemotherapy. there has been controversy about whether hormonal treatments may have protective effects against the severe spermatogenic damage caused by chemotherapy or irradiation. recently, it has been proposed that gonadotrophin-releasing hormone (gnrh) analogs administered after testicular damage stimulate the recovery of spermatogenesis. in this study, we have investigated the effects of gnrh agonist, leuprorelin, ... | 2001 | 11903688 |
| elimination of donor-specific alloreactivity prevents cytomegalovirus-accelerated chronic rejection in rat small bowel and heart transplants. | the primary cause for late failure of vascularized allografts is chronic rejection (cr) characterized by transplant vascular sclerosis (tvs). cytomegalovirus (cmv) infection accelerates tvs and cr by unclear mechanisms involving direct effects of cmv, indirect effects of the recipient's immune response to cmv, or interactions between cmv and the recipient's alloreactivity. this study examined the role of cmv and the alloreactive response in the development of tvs using bone marrow chimerism (bmc ... | 2002 | 11907411 |
| antibodies against gangliosides: a link between preceding infection and immunopathogenesis of guillain-barré syndrome. | autoantibodies against gangliosides gm1 and gq1b, characteristic cell surface glycolipids of the nervous system, are present in specific clinical types of guillainbarré syndrome (gbs). close associations of anti-gm1 with acute motor axonal neuropathy, and of anti-gq1b with miller fisher syndrome, strongly suggest that these antibodies contribute to neuropathy pathogenesis. immune responses against gangliosides are suspected to originate as a result of molecular mimicry between gangliosides and l ... | 2002 | 11909748 |
| the fluorescence biodistribution and kinetics of aminolevulinic acid induced protoporphyrin ix in the bladder of a rat model with orthotopic urothelial carcinoma. | photodynamic therapy is an alternative intravesical therapy modality for superficial bladder cancer. aminolevulinic acid (ala) induces the production of the endogenous photosensitizer protoporphyrin ix (ppix). we compared intravenous versus intravesical administration of ala and established the proper timing and dose of ala for photodynamic therapy. to characterize the distribution of ala in rat bladder tumor and normal bladder layers a cooled charge coupled device camera was used. | 2002 | 11912446 |
| cyclosporine does not enhance the development of accelerated coronary artery disease: experimental study in a rat cardiac transplant model. | among other factors, cyclosporine (csa) is linked with the development of accelerated coronary artery disease (acad) after transplantation. the objective of this study was to assess the influence of different csa regimens on acad after rat heart transplantation. | 2002 | 11927218 |
| a genotype-phenotype correlation between null-allele mutations in the ferrochelatase gene and liver complication in patients with erythropoietic protoporphyria. | erythropoietic protoporphyria (epp), an inborn error of heme metabolism, causes in the majority of the patients only a symptom of photosensitivity. however, around 2% of the epp sufferers develop liver complication in the form of liver cirrhosis and progressive liver failure. mutations in the human ferrochelatase (fech) gene causing epp are highly heterogeneous and mostly family-specific. actually, 62 fech mutations have been published, 48 of them are "null allele" mutations inducing the formati ... | 2002 | 11929053 |
| spatial and habitat distribution of anopheles gambiae and anopheles arabiensis (diptera: culicidae) in banambani village, mali. | we studied the larval distribution and composition of anopheles arabiensis patton, an. gambiae s.s. giles, and its forms, among local habitats; and their association with the adults between these habitats in banambani village, mali during the mid-rainy seasons of 1997-1999. for species and form identification we used polymerase chain reaction (pcr) and pcr-restriction fragment-length polymorphism (rflp). differences among species in the distribution of larvae were observed in 1998, but not in 19 ... | 2002 | 11931274 |
| effects of inactivity on glycolytic capacity of single skeletal muscle fibers in adult and aged rats. | the purpose of this study was to determine the effects of inactivity on lactate dehydrogenase (ldh) enzyme activity (expressed in nmol/g dry weight x hour) in single skeletal musclefibers from the soleus muscle in adult and aged rats. fourteen 12-month-old andfifteen 30-month-old fisher 344 brown norway f1 hybrid rats were randomly assigned to control, 1 week of hindlimb unweighting (hu1), or 2 weeks of hindlimb unweighting (hu2). with age, a significant decrease in ldh enzyme activity occurred ... | 2001 | 11931526 |
| detection and prevalence of alpha-latrotoxin-like effects of serum from patients with guillain-barré syndrome. | anti-gq1b antibodies are associated with the miller fisher syndrome (mfs), a variant of the guillain-barré syndrome (gbs). in the ex vivo mouse diaphragm, anti-gq1b-positive mfs serum induces muscle fiber twitching, a temporary dramatic increase of spontaneous quantal acetylcholine release, and transmission blockade at neuromuscular junctions (nmjs). these effects resemble those of alpha-latrotoxin (alpha-ltx) and are induced by antibody-mediated activation of complement. we developed an assay f ... | 2002 | 11932973 |
| anti-lm1 antibodies in the sera of patients with guillain-barré syndrome, miller fisher syndrome, and motor neuron disease. | this study is designed to establish whether sialosylneolactotetraosylceramide (lm1), a major component of human peripheral nerve ganglioside, is a potential target antigen for the development of peripheral autoimmune neuropathies such as guillain-barré syndrome (gbs) and miller fisher syndrome (mfs). serum antibodies against lm1 in 116 patients with gbs, 56 patients with mfs, 88 patients with motor neuron disease (mnd) and 60 normal control subjects were quantified using enzyme-linked immunosorb ... | 2002 | 11939352 |
| correlation of survivin mrna detection with histologic diagnosis in normal endometrium and endometrial carcinoma. | the objective of this study was to determine if survivin mrna expression is a marker of endometrioid adenocarcinoma and if survivin mrna levels correlate with tumor grade and stage. | 2002 | 11942908 |
| antibody response against perlecan and collagen types iv and vi in chronic renal allograft rejection in the rat. | chronic rejection is the leading cause of late renal transplant failure. various structural lesions are observed in grafts undergoing chronic rejection including glomerular basement membrane (gbm) duplications. the well-established fisher (f344) to lewis (lew) rat renal transplant model for chronic rejection was used to assess the presence and role of the humoral immune response against graft antigens during chronic rejection. lew recipients of f344 allografts develop transplant glomerulopathy a ... | 2002 | 11943715 |
| exercise conditioning attenuates the hypertensive effects of nitric oxide synthase inhibitor in rat. | many individuals with cardiovascular diseases undergo periodic exercise conditioning with or with out medication. therefore, this study investigated the interaction of exercise training and chronic nitric oxide synthase (nos) inhibitor (nitro-l-arginine methyl ester, l-name) treatment on blood pressure and its correlation with aortic nitric oxide (no), antioxidant defense system and oxidative stress parameters in rats. fisher 344 rats were divided into four groups: (1) sedentary control, (2) exe ... | 2002 | 11952154 |
| benign intracranial hypertension: atypical presentation of miller fisher syndrome? | acute ocular paresis, nausea, vomiting, and headaches associated with high intracranial pressure without obvious intracranial pathology are typical features of benign intracranial hypertension. we describe two young children whose presentation, initially suggestive of idiopathic or benign intracranial hypertension, evolved to comprise ophthalmoplegia, ataxia, and areflexia. this triad characterizes miller fisher syndrome, a clinical variant of guillain-barré syndrome that occurs rarely among chi ... | 2002 | 11955933 |
| induction of human mdr1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate nf-kappab signaling. | the expression of p-glycoprotein encoded by the multidrug resistance (mdr1) gene is associated with the emergence of the mdr phenotype in cancer cells. human mdr1 and its rodent homolog mdr1a and mdr1b are frequently overexpressed in liver cancers. however, the underlying mechanisms are largely unknown. the hepatocarcinogen 2-acetylaminofluorene (2-aaf) efficiently activates rat mdr1b expression in cultured cells and in fisher 344 rats. we recently reported that activation of rat mdr1b in cultur ... | 2002 | 11960367 |
| genetic status of cell cycle regulators in squamous cell carcinoma of the oesophagus: the cdkn2a (p16(ink4a) and p14(arf) ) and p53 genes are major targets for inactivation. | we determined inactivation of the cdkn2a (p16(ink4a) and p14(arf)) gene in 21 cases of oesophageal squamous cell carcinoma (oscc). the tumours were also analysed for mutations in exons 5-8 and allelic losses in the p53 gene. in addition, we screened the cdkn2b (p15 ink4b), cdkn2c (p18 ink4c), cdk4 and p53r2 genes for mutations in the tumour tissues. besides concomitant alterations in the cdkn2a and p53 loci in more than half of the cases, our results showed that in 18 oscc (86%) the cdkn2a (p16( ... | 2002 | 11960918 |
| [experimental data for administration of insulin-like growth factor 1 (igf-1) and basic fibroblast growth factor (bfgf) for prevention of radiation myelopathy]. | current models of radiation myelopathy provide a rationale for growth factor-based prevention strategies. thus, we tested whether insulin-like growth factor-1 (igf-1) and basic fibroblast growth factor (bfgf) alone or in combination modulate radiation tolerance of the rat cervical spinal cord. | 2002 | 11962191 |
| inhibition of endothelin-1 improves survival and vasculopathy in rat cardiac transplants treated with cyclosporine. | in animal models, endothelin-1 (et-1) blockade attenuates transplant vasculopathy and chronic allograft dysfunction even in the absence of cyclosporine (csa). as csa has side effects and et-1 antagonism alone has significant benefits, we postulated that allograft survival could be significantly improved by combining an endothelin-converting enzyme inhibitor with low-dose csa. | 2002 | 11965031 |
| altered regulation of matrix metalloproteinase-2 in aortic remodeling during aging. | to elucidate potential mechanisms of enhanced type 2 matrix metalloprotease levels and activity within the thickened aged rat aorta, the present study measured its mrna and protein levels and those of its membrane bound activator, mt1-mmp, its endogenous tissue inhibitor, timp-2, tissue type, and urokinase plasminogen activators and their receptors, and an inhibitor of plasminogen activation in aortae from fisher 344x brown norway rats, 2 to 30 months of age. semiquantitative immunohistochemistr ... | 2002 | 11967241 |
| combination treatment with an et(a)-receptor blocker and an ace inhibitor is not superior to the respective monotherapies in attenuating chronic transplant nephropathy in a 'fisher-to-lewis' rat model. | specific endothelin a (et(a))-receptor blockade and ace inhibition attenuate chronic transplant nephropathy (ctn) in the 'fisher-to-lewis' rat model. it is unknown (i) which of both pharmacological interventions attenuates ctn more effectively and (ii) whether combination therapy exerts additive nephroprotection. | 2002 | 11981063 |
| effects of sho-saiko-to on hepatocarcinogenesis and 8-hydroxy-2'-deoxyguanosine formation. | oxidative stress plays an important role in hepatocarcinogenesis. although sho-saiko-to (tj-9), a japanese herbal medicine which has been recently administered to patients with chronic liver disease in japan, prevents hepatocarcinogenesis, the mechanism by which tj-9 protects against cancer development is not fully understood. 8-hydroxy-2'-deoxyguanosine (8-ohdg), a dna adduct by reactive oxygen species, is known as a parameter of genetic risk for hepatocarcinogenesis. to clarify whether the pre ... | 2002 | 11981762 |
| pedigree-based quantitative genetic analysis of interindividual variation in circulating levels of igfbp-3. | circulating levels of insulin-like growth factor binding protein-3 (igfbp-3) vary greatly between normal individuals, but until now little attention has been given to the study of the genetic factors involved in igfbp-3 variability in healthy populations. the present study investigated the extent and pattern of the possible genetic influences on plasma levels of igfbp-3 in 91 nuclear and more complex families, totaling 396 individuals (201 males and 195 females) of caucasian ethnic origin. the v ... | 2002 | 11984698 |
| strain differences in angiotensin-converting enzyme and angiotensin ii type i receptor expression. possible implications for experimental chronic renal transplant failure. | the fisher to lewis (f-l) model of renal transplantation (rtx) is widely used. rtx from f to l without immunosuppressive treatment results in 50% survival, whereas l to f results in survival rates similar to syngrafts. when treated with an angiotensin-converting enzyme (ace) inhibitor or antihypertensive triple therapy, renal damage is markedly reduced in f-l allografts. despite similar reductions in blood pressure, the ace inhibitor (ace-i) is more effective than antihypertensive triple therapy ... | 2002 | 11984748 |
| mapping multiple genes for quantitative or complex traits. | models for complex and quantitative traits that involve multiple, possibly interacting, genes are described. methods of linkage analysis are developed that utilize special features of these models, and their power is compared with that of simple genome scans that ignore these special features. our calculations show that for family-based nonparametric linkage analysis in human genetics, in contrast to experimental genetics, there are limits to the increase in power that can be achieved by correct ... | 2002 | 11984864 |
| [acute autoimmune polyradiculoneuropathies]. | landry guillain barr sthrol syndrome (lgbs) is an acute autoimmune monophasic and selflimiting polyradiculoneuropathy affecting patients aged 19 to 59 years (1.7/100,000/year) more than below 18 year of age (0.8/100,000/year). diagnostic criteria require: i. progressive motor weakness of more than one limb, and ii) absent muscle stretch reflexes. features that strongly support the diagnosis are: 1. cease of progression of weakness by 4 weeks, relative symmetrical involvement of the limbs, prese ... | 2002 | 11988913 |
| bacterial translocation and intestinal morphological findings in jaundiced rats. | the susceptibility to sepsis in obstructive jaundice may be related to bacterial translocation (bt) from the gastrointestinal tract. we evaluated bt to visceral organs and morphological changes of the intestinal mucosa in a rat model of obstructive jaundice. animals were randomly divided into two groups: in group a the common bile duct was tied and divided, while group b had the bile duct mobilized but not tied. after seven days, peritoneal swabs and liver, spleen, pancreas, lung, mesenteric lym ... | 2002 | 11991630 |
| characteristics of bacteremia between community-acquired and nosocomial klebsiella pneumoniae infection: risk factor for mortality and the impact of capsular serotypes as a herald for community-acquired infection. | although several epidemiological surveys of klebsiella clinical isolates have been performed, few studies have correlated the clinical isolate with disease. | 2002 | 11996612 |
| numerical aberrations of chromosome 9 in bladder cancer. a possible prognostic marker for early tumor recurrence. | to investigate whether nonrandom aberrations of chromosomal numbers could predict tumor recurrence in patients with bladder cancer, archival urine cytology specimens (giemsa-stained) from patients previously treated for transitional cell carcinoma of the urinary bladder were studied retrospectively by fluorescence in situ hybridization. a total of 48 patients (ptis, 6; pta, 2: pt1, 32; and pt2-4, 8) were consecutively enrolled in this study, and numerical aberrations of chromosomes 9 and 17 were ... | 2002 | 11996795 |
| oxidative injury due to chronic nitric oxide synthase inhibition in rat: effect of regular exercise on the heart. | many individuals with cardiac diseases undergo periodic physical conditioning with or without medication. therefore, this study investigated the interaction of physical training and chronic nitric oxide synthase (nos) inhibitor (nitro-l-arginine methyl ester, l-name) treatment on blood pressure (bp), heart rate (hr) and cardiac oxidant/antioxidant systems in rats. fisher 344 rats were divided into four groups and treated as follows: (1) sedentary control (sc), (2) exercise training (et) for 8 we ... | 2002 | 12009427 |
| fracture strength after dynamic loading of endodontically treated teeth restored with different post-and-core systems. | prefabricated metal and ceramic posts can be used with direct or indirect cores as an alternative to the conventional cast post and core. it is unclear how the fracture strength of zirconia posts with composite or ceramic cores and titanium posts with composite cores compares to the fracture strength of gold posts and cores after dynamic loading. | 2002 | 12011861 |
| reduction of hepatocarcinogenesis by ursodeoxycholic acid in rats. | ursodeoxycholic acid (udca) is used worldwide for treatment of primary biliary cirrhosis and chronic liver diseases. however, its action on hepatocarcinogenesis remains to be explored. to clarify its effect, in vivo and in vitro experiments were performed. ninety fisher 344 rats were fed a standard diet (group 1, n = 30), a standard diet supplemented with 0.1% udca (group 2, n = 30) and 0.3% udca (group 3, n = 30). the rats were given an i.p. injection of diethylnitrosamine (den) weekly for 6 we ... | 2002 | 12016164 |
| early and late injury to renal transplants from non-heart-beating donors. | the lack of adequate numbers of kidneys for transplantation has stimulated interest in the use of organs from non-heart-beating donors (nhbds). the short- and long-term effects of this risk factor on kidney isografts and allografts were examined with a rat model. | 2002 | 12023626 |
| cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis. | preneoplastic and neoplastic hepatocytes undergo c-myc up-regulation and overgrowth in rats genetically susceptible to hepatocarcinogenesis, but not in resistant rats. because c-myc regulates the prb-e2f pathway, we evaluated cell cycle gene expression in neoplastic nodules and hepatocellular carcinomas (hccs), induced by initiation/selection (is) protocols 40 and 70 weeks after diethylnitrosamine treatment, in susceptible fisher 344 (f344) rats, and resistant wistar and brown norway (bn) rats. ... | 2002 | 12029619 |
| genetics of human body size and shape: body proportions and indices. | the study of the genetic component in morphological variables such as body height and weight, head and chest circumference, etc. has a rather long history. however, only a few studies investigated body proportions and configuration. | 2002 | 12031137 |
| preferential uptake of zinc, manganese, and rubidium in rat brain tumor. | the search for radionuclides that can be an index of viability in proliferating cells is important for nuclear medicine diagnosis of brain tumors. on the basis of the finding that 65zn is preferentially taken up in rat brain tumors, the uptake of various radionuclides was examined in rat brain tumor by using the multitracer technique. male fisher rats were intrahippocampally injected with c6 glioma cells. fourteen days after implantation, the radioactive multitracer solution was injected into th ... | 2002 | 12031887 |
| diphyllobothriasis: update on human cases, foci, patterns and sources of human infections and future considerations. | diphylobothriasis is a well documented disease of humans. on a world scale new infections are reported regularly, especially from russia and parts of japan. globally, new species have been discovered and the etiology of the disease may be changing. human infections appear to be in decline but it is not clear if the sources of infection are also in decline or if public health awareness has improved. in north america there has been a decline in human cases while in south america an increase in rep ... | 2001 | 12041607 |
| selenium deficiency in fisher-344 rats decreases plasma and tissue homocysteine concentrations and alters plasma homocysteine and cysteine redox status. | the purpose of the present study was to determine the effect of graded amounts of dietary selenium on plasma and tissue parameters of methionine metabolism including homocysteine. male weanling fisher-344 rats (n = 7-8/group) were fed a selenium-deficient, torula yeast-based diet, supplemented with 0 (selenium deficient), 0.02, 0.05 or 0.1 microg (adequate) selenium (as selenite)/g diet. after 61 d, plasma total homocysteine and cysteine were decreased (p < 0.0001) and glutathione increased (p < ... | 2002 | 12042420 |
| factors that predict site of outflow target artery anastomosis in infrainguinal revascularization. | lower extremity revascularization is indicated for limb salvage and incapacitating leg claudication. many risk factors (age, hypertension, diabetes, tobacco use, dyslipidemia, etc) have been associated with atherosclerosis and the development of peripheral arterial occlusive disease. however, whether these risk factors or the surgical indication (claudication or limb salvage) influences the extent and location of infrainguinal disease and hence the target artery (distal anastomosis) is unclear. ... | 2002 | 12042719 |
| in vitro radiation-induced effects on rat tracheal epithelial cells. i) different radiosensitivity of cell inactivation after alpha and gamma irradiations. | in order to compare the radiotoxicity of alpha- and gamma-irradiations, primary cultures of tracheal epithelial cells from two rat strains, sprague dawley (sd) and wistar furth/fisher f344 (wf/fi) rats, were irradiated with 241am alpha-particles or 60 co gamma-rays. the survival ratio for each of the two rat strain cells appeared to be statistically different after high-let irradiation. wf/fi rat cells were 1.7-times more radiosensitive than sd rat cells, whereas no difference was observed follo ... | 2002 | 12056327 |
| in vitro radiation-induced effects on rat tracheal epithelial cells. ii) different preneoplastic cell transformation after alpha and gamma irradiations. | in order to compare the cell transformation induced by alpha- and gamma-irradiation, primary cultures of tracheal epithelial cells from two rat strains, sprague dawley (sd) and wistar furth/fisher f344 (wf/fi) rats, were irradiated with 241am alpha-particles or 60 co gamma-rays. the relative transformation frequency (rtf) for wf/fi primary cells was very close to the level of the spontaneous incidence and independent on the two irradiation types used. on the contrary, the rtf for the sd primary ... | 2002 | 12056328 |
| genome-wide dynamic transcriptional profiling of the light-to-dark transition in synechocystis sp. strain pcc 6803. | we report the results of whole-genome transcriptional profiling of the light-to-dark transition with the model photosynthetic prokaryote synechocystis sp. strain pcc 6803 (synechocystis). experiments were conducted by growing synechocystis cultures to mid-exponential phase and then exposing them to two cycles of light/dark conditions, during which rna samples were obtained. these samples were probed with a full-genome dna microarray (3,169 genes, 20 samples) as well as a partial-genome microarra ... | 2002 | 12057963 |
| impact of habitat degradation on phlebotominae (diptera: psychodidae) of tropical dry forests in northern colombia. | we examined changes in the phlebotomine fauna resulting from human intervention in a tropical dry forest of northern colombia where visceral and cutaneous leishmaniases are endemic. a natural forest reserve (colosó) and a highly degraded area (san andrés de sotavento [sas]) were sampled monthly for 8 mo using shannon traps, sticky traps, and resting-site collections. overall abundances were higher in colosó (15,988) than in sas (2,324). and species richness of phlebotomines was greater in the fo ... | 2002 | 12061439 |
| age increases cardiac galpha(i2) expression, resulting in enhanced coupling to g protein-coupled receptors. | cardiac g protein-coupled receptors that function through stimulatory g protein galpha(s), such as beta(1)- and beta(2)-adrenergic receptors (beta(1)ars and beta(2)ars), play a key role in cardiac contractility. recent data indicate that several galpha(s)-coupled receptors in heart also activate galpha(i), including beta(2)ars (but not beta(1)ars). coupling of cardiac beta(2)ars to galpha(i) inhibits adenylyl cyclase and opposes beta(1)ar-mediated apoptosis. dual coupling of beta(2)ar to both ga ... | 2002 | 12065589 |
| prediction of survival in stage i lung carcinoma patients by telomerase function evaluation. | telomerase activity and telomerase reverse transcriptase (htert) expression are elevated in human malignancies. we have investigated telomerase activity measured by the telomeric repeat amplification protocol (trap) assay and htert levels by real-time rt-pcr in stage i non-small-cell lung carcinomas. the purposes of our study included the comparison of these two techniques in the assessment of telomerase function and the evaluation of their prognostic significance. telomerase activity and htert ... | 2002 | 12065683 |
| [helicobacter pylori gastric infection is a protection factor for gastroesophageal reflux disease]. | to know the relationship between endoscopic esophagitis and h. pylori infection. | 2002 | 12066427 |
| bone response to calcium phosphate-coated and bisphosphonate-immobilized titanium implants. | thin calcium phosphate (ca-p) coatings have been introduced to overcome the shortcomings of plasma-sprayed ca-p coatings. in our previous experiments, thin ca-p coatings also enabled the immobilization of bisphosphonate, which is a drug used to treat osteoporosis. the present study was designed to evaluate the bone response to titanium implants treated with a thin ca-p coating and bisphosphonate. forty cylindrical commercially pure titanium implants with a length of 7 mm and a diameter of 3 mm w ... | 2002 | 12069328 |
| protection against dextran sulfate sodium-induced colitis by microspheres of ellagic acid in rats. | ellagic acid (ea), a naturally occurring plant phenol, has the antioxidant and anti-inflammatory activities. in the present study, we examined the effect of ea contained in microspheres on the ulcerative colitis induced experimentally in rats by dextran sulfate sodium (dss). experimental colitis was induced in male fisher 344 rats by daily treatment with 3% dss solution in drinking water for 7 days. ea of microspheres (mcea: 1 approximately 10 mg/kg as ea contents) was administered p.o. twice da ... | 2002 | 12074942 |
| a novel natural product compound enhances camp-regulated chloride conductance of cells expressing cftr[delta]f508. | cystic fibrosis (cf) results from mutations in the cystic fibrosis transmembrane conductance regulator (cftr) gene, which encodes a chloride channel localized at the plasma membrane of diverse epithelia. the most common mutation leading to cf, delta f508, occurs in the first nucleotide-binding domain (nbd1) of cftr. the delta f508 mutation disrupts protein processing, leading to a decreased level of mutant channels at the plasma membrane and reduced transepithelial chloride permeability. partial ... | 2002 | 12080183 |
| thymosin alpha1 inhibits mammary carcinogenesis in fisher rats. | the effects of thymosin alpha1 (talpha1) on mammary carcinogenesis was investigated in fisher rats. mammary carcinomas were observed 3 months after n-nitrosomethylurea (nmu) injection (10mg, i.p.) into fisher rats. daily administration of talpha1 (10 microg, s.c.) reduced mammary carcinoma incidence and prolonged survival time. animals treated with exogenous talpha1 had a significantly greater blood white cell density than control fisher rats. these results suggest that talpha1 prevents mammary ... | 2002 | 12084534 |
| bovine pericardium vs dacron for patch angioplasty after carotid endarterectomy: a prospective randomized study. | bovine pericardium (bp) demonstrates improved intraoperative hemostasis and equivalent perioperative morbidity compared with dacron when used as patch material for angioplasty following carotid endarterectomy. | 2002 | 12093332 |