| neodymium-yag laser sclerostomy in primates. | a one-stage sclerostomy procedure was performed "noninvasively" in four cynomolgus monkeys solely with the neodymium-yag laser. the neodymium (nd)-yag laser was focused, for the most part, a few diopters behind the focus of the helium-neon aiming beam. this enabled optical breakdown to occur entirely within the sclera to produce a perforating micropuncture of the scleral tissue. two monkeys were treated with higher energy (23 and 24 joules) and two were treated at lower energy levels (12 and 14 ... | 1985 | 3840366 |
| the afferent connections of the substantia innominata in the monkey, macaca fascicularis. | the afferent connections of the substantia innominata and the magnocellular nuclei within it (the nucleus of the horizontal limb of the diagonal band, nhdb, and the nucleus basalis of meynert, nbm) have been studied with anterograde and retrograde axonal tracing techniques. prominent inputs arise in the amygdaloid complex, restricted areas of the cerebral cortex, parts of the thalamus and hypothalamus, and nuclei of the lower brainstem. autoradiographic tracing experiments indicate that the amyg ... | 1985 | 3841131 |
| the relationship between the number of the bacterium streptococcus mutans at discrete sites on the dentition of macaque monkeys (macaca fascicularis) and the subsequent development of dental caries. | sixteen consecutively-born monkeys were used in a longitudinal study to determine the changes occurring in the total number of bacteria in the palatal grooves of the upper left first deciduous molar teeth, following the introduction of a sucrose-based diet. the total number of bacteria recovered from the grooves increased significantly following the diet change. twenty-nine days after the diet change, the number of streptococcus mutans had increased from a median value of less than 10(2) to appr ... | 1985 | 3857890 |
| infectivity and natural transmission of the bacterium streptococcus mutans in monkeys (macaca fascicularis) at different ages. | oral inoculation of adolescent monkeys with laboratory strains of streptococcus mutans resulted in only sporadic implantation. oral colonization of all strains, except possibly one, was not enhanced by dietary sucrose compared with glucose nor by precleaning of accessible tooth surfaces. infant animals were more susceptible to implantation by laboratory-maintained strains of strep. mutans than adolescent or adult animals. this difference was magnified when in-vivo maintained strep. mutans strain ... | 1985 | 3857904 |
| mandibular condylar structure and growth in macaca fascicularis are related to skeletal rather than dentitional development. | mandibular condyles of eight male monkeys (macaca fascicularis), ranging in weight from 1.5 to 3.0 kg, were examined using histometric, radioautographic and stereologic techniques. the animals were classified on the basis of their dentitional and, as judged from radiographs of the hand and wrist, of their skeletal development. this allowed morphometric parameter means to be plotted as a function of four dentitional and five skeletal levels of maturation. the influence of dentitional and skeletal ... | 1985 | 3860498 |
| morphology of polymorphonuclear neutrophils during periodontal disease in the cynomolgus monkey. | the polymorphonuclear neutrophil (pmn) appears to be an important cell in the protection of the host from pathogenic periodontal micro-organisms. the purpose of the present histological studies was to observe the emigration of the pmn from the gingival vessels to the periodontal pocket during gingivitis and ligature-induced periodontitis in the cynomolgus monkey. 2 adult female monkeys were treated by application of a silk ligature around selected posterior teeth. after 9 weeks, the monkeys were ... | 1985 | 3860520 |
| establishment and distribution of the bacteria actinomyces viscosus and actinomyces naeslundii in the mouths of monkeys (macaca fascicularis). | the colonization of the mouth by the two actinomyces species, postulated to be members of a basic plaque flora, was studied in 27 consecutively-born neonatal monkeys. bacteria adherent to the tongue and cheek surfaces were sampled from each monkey soon after birth (mean age = 3.2 days). the tongue and cheek surfaces and the labial surfaces of the incisor teeth were sampled at 4, 8 and 12 weeks of age. from only one neonatal sample were actinomyces species isolated. by 4 weeks of age, the incisor ... | 1985 | 3861145 |
| pharmacological testing in the laser-induced monkey glaucoma model. | glaucoma was induced in cynomolgus monkeys by photocoagulating the trabecular meshwork with the argon laser. repeat treatments were often necessary and wide intraocular pressure fluctuations were characteristic. baseline intraocular pressure was measured with a calibrated pneumatonometer hourly for six hours. on a succeeding day a baseline measurement was made, 50 microliter of the drug to be tested applied, and six hourly measurements of intraocular pressure repeated. the effects on intraocular ... | 1985 | 3861296 |
| innervation of the conjunctiva. | a parasympathetic pathway from the facial nerve to the conjunctiva was confirmed. many conjunctival nerve fibres were degenerated following pterygopalatine ganglion lesion in cynomolgus monkeys. nerve terminal degeneration was found mainly in the large vessel walls and adjacent to the subepithelial capillaries. ache positive nerve fibres of undenervated tissue, probably representing the cholinergic fibres of facial nerve origin, and sympathetic nerve terminals, identified by their small granular ... | 1985 | 3862271 |
| evaluation of timefurone, a new anti-atherosclerotic drug, for its effects on lipoprotein cholesterol in male cynomolgus monkeys fed an atherogenic diet for 18 months. | forty male cynomolgus monkeys were fed a nutritionally complete diet containing butter and 0.5% cholesterol for 18 months to ensure development of atherosclerosis. timefurone was administered daily at 10 mg/kg/day. lipoprotein cholesterol parameters were measured every 4 weeks and clinical chemistries were done at approximately 8-week intervals. low density lipoprotein cholesterol [ldl-c] was significantly reduced 24-45% at all time periods and total-c was lowered 17-23% at weeks 12, 16, and 24- ... | 1985 | 3863622 |
| [the canine gubernacular foramen in crab-eating monkeys (macaca fascicularis)]. | | 1985 | 3865275 |
| hypocholesterolemic effect of khellin and khelloside in female cynomolgus monkeys. | khellin and khelloside (khellol glucoside) were examined in female cynomolgus monkeys to substantiate their ability to favorably modify serum lipoprotein cholesterol. clinical chemistry parameters were also measured to obtain information indicative of possible drug toxicity. both drugs were evaluated in two week multiple-dose studies and after a single oral dose. after two weeks at 20 mg/kg per day, khellin and khelloside significantly lowered low density lipoprotein cholesterol (ldl-c) by 87% a ... | 1985 | 3865654 |
| transmission of the oral bacterium streptococcus mutans to young macaca fascicularis monkeys from human nursery attendants. | streptococcus mutans was detected in the mouths of 2 out of 7 infant monkeys that had been delivered by caesarian section and nursery-reared without contact with their mothers or other monkeys. their human nursery attendants all harboured strep. mutans biotype c (c serotype) as found in the monkeys. bacteriocin studies also indicated similarity between the animal and human isolates. these findings suggest that the infant monkeys acquired strep. mutans from the nursery personnel. evidence for the ... | 1985 | 3868976 |
| substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography. | two substituted benzamides, flb 524 and raclopride, were labeled with 11c and examined for their possible use as ligands for positron emission tomography (pet)-scan studies on dopamine-2 (d-2) receptors in the brains of monkeys and healthy human subjects. both ligands allowed the in vivo visualization of d-2 receptor binding in the corpus striatum caudate nucleus/putamen complex in pet-scan images. [11c]raclopride showed a high ratio of specific striatal to nonspecific cerebellar binding, and th ... | 1985 | 3873656 |
| spinal cord metabolism of the 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated monkey. | nine monkeys (macaca fascicularis) were used in this study. four monkeys were rendered parkinsonian by administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) 0.5 mg/kg intravenously. three animals were injected once daily for 4 days, and one animal once weekly for 4 weeks. five animals were used as controls. all mptp-treated animals demonstrated the same clinical features which included akinesia, bradykinesia, a flexed posture of the trunk and all extremities, decreased initiation ... | 1985 | 3875382 |
| the monkey vertical vestibuloocular response: a frequency domain study. | we studied the vertical vestibuloocular response (vvor) in seven cynomolgus monkeys. eye movements were measured by the search coil method. we tested the monkeys by rotating them about their interaural axis, which was colinear with gravity. each monkey was tested by using a standard rotational paradigm that consisted of discrete sinusoidal oscillations at three frequencies (0.01, 0.1, and 1.0 hz) and six peak velocities (5, 10, 30, 60, 100, and 150 degrees/s). the standard rotational paradigm wa ... | 1985 | 3876412 |
| changes in the local cerebral metabolic rate for glucose in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) primate model of parkinson's disease. | nine adult monkeys (macaca fascicularis) were used in this study. five animals were used as controls. three animals were injected intravenously daily with 0.5 mg/kg of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) over a 4-day period; one animal was injected weekly over a 4-week period. neurological examination of the mptp-treated animals revealed a flexed posture of trunk and extremities, bradykinesia, increased tone without cogwheel rigidity, loss of vestibular righting reflexes, decreas ... | 1985 | 3878182 |
| lack of metabolism of timolol by ocular tissues. | the ocular metabolism of timolol has been studied in the iris/ciliary body, vitreous humor, neuro-retina and cornea from an albino rabbit, pigmented rabbit and cynomolgus monkey by incubating tissues isolated from these animals with radiolabeled drug for 20 hours at 37 degrees c in hanks' balanced salts solution. after removal of the tissues by centrifugation and subsequent deproteinization, supernatants were mixed with unlabeled timolol and analyzed by isocratic reverse phase high performance l ... | 1985 | 3880080 |
| in vitro gonadotropin-releasing hormone release from hypothalamic tissues of ovariectomized estrogen-treated cynomolgus macaques. | the effects of in vivo 17 beta-estradiol (e2) treatment on in vitro gnrh release and serum lh levels were studied to determine the loci of e2 feedback actions and to examine the hypothalamic mechanisms by which this steroid may regulate lh secretion in monkeys. ovariectomized cynomolgus macaques received sc silastic capsule implants containing e2 and were killed 12, 36, 42, or 48 h later. at least one control (ctl) animal received a blank implant and was killed concurrently with each e2-treated ... | 1985 | 3880545 |
| apolipoprotein e synthesis in peripheral tissues of nonhuman primates. | the tissue distribution of apolipoprotein (apo) e synthesis in the cynomolgus monkey, macaca fascicularis, was determined via short-term organ culture with radiolabeled amino acid. tissue extracts were reacted with antiserum to apo-e, and immunoprecipitates were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. newly synthesized apo-e was detected in liver, adrenal, testis, lung, spleen, mesenteric lymph node, and kidney. peripheral and hepatic apo-e showed the same electrop ... | 1985 | 3882695 |
| genotoxic potential of acephate technical: in vitro and in vivo effects. | the genotoxic potential of acephate technical (at) in vitro and in vivo has been studied in bioassays detecting primary dna damage, chromosomal alterations, and gene mutation. results from in vitro assays have ranged from negative to weakly positive; at is apparently a direct-acting agent in these tests. however, expressed in terms of molar potency, at has generally been at least 100-1000 times less potent than known positive mutagens tested in vitro. following in vivo exposure at maximum tolera ... | 1985 | 3890268 |
| relationship between fetal position and stillbirth in the cynomolgus monkeys (macaca fascicularis): retrospective analysis. | retrospective analyses were made on the relationship between fetal position and stillbirth, using 703 pregnant cynomolgus monkeys. incidence of the breech position was 59.1% to 12 weeks of gestation. the rate decreased stepwise to 10.4% on the day before delivery. twenty-one (65.6%) of 32 monkeys who were in the breech position on the day before delivery had stillbirths, whereas only one stillbirth occurred among 275 monkeys whose fetuses were in the cephalic position. | 1985 | 3892011 |
| reduction in tissue ldl accumulation during coronary artery regression in cynomolgus macaques. | the aim of this study was to determine whether the amount of ldl that had accumulated in the coronary arteries of cynomolgus monkeys during an 18-month period on a hypercholesterolemic (h) diet was reduced during subsequent periods of 6 and 12 months on a normolipemic (n) diet. this was performed by assessing the accumulation of ldl in the left anterior descending (lad) branch of the left coronary artery within an area 4 mm from its origin, since this region contained the largest lesions in the ... | 1985 | 3896252 |
| immunocytochemical localization of s-100 protein in interstitial cells of the monkey macaca irus pineal gland. | pineal interstitial cells of the monkey macaca irus were shown to react with an anti-human s-100 protein antibody, using the indirect immunoperoxidase technique on sections of paraplast-embedded pineal glands. immunoreactivity was seen in the cytoplasm of the cells, stellate in shape and intermingled with pinealocytes; the latter did not stain with the antiserum against s-100 protein. immunoreactivity was also present in the nuclei, as was reported in various other cell types immunostained with ... | 1985 | 3897913 |
| pulmonary responsiveness to methacholine and disodium hexachloroplatinate (na2ptcl6) aerosols in cynomolgus monkeys (macaca fascicularis). | hyperreactivity of the airways is a common finding in human asthma, and responsiveness to inhaled methacholine aerosols is routinely used for assessing airway irritability. workers in precious metal refineries demonstrate pulmonary signs suggestive of asthma, presumably related to exposure to soluble platinum salts. in these workers, evidence of physiologic dysfunction precedes immunologic evidence (skin test) of disease, suggesting an initial pharmacologic mechanism. with a primate animal model ... | 1985 | 3898469 |
| metabolic changes during maturation of male monkeys: possible signals for onset of puberty. | there is a close relationship between the metabolic status of a maturing animal and the timing of puberty onset. however, the signals linking metabolic status to the maturation of the reproductive axis remain unknown. we looked for metabolic differences before and after puberty by comparing plasma profiles of insulin, glucose, amino acids, beta-hydroxybutyrate, and glycerol between juvenile and adult monkeys in fed and fasted states. thirteen juvenile and 13 adult male crab-eating macaques (maca ... | 1985 | 3901775 |
| the role of endogenous gonadotropin-releasing hormone in the control of luteinizing hormone and testosterone secretion in the juvenile male monkey, macaca fascicularis. | to determine what changes occur in the activity of gonadotropin-releasing hormone (gnrh) neurons during pubertal development in primate species we tested the hypotheses that there are morphologic differences between gnrh-containing neurons in juvenile versus adult monkeys, and the low activity of the reproductive axis is governed by hypothalamic gnrh release in monkeys prior to puberty. we removed the brains from 5 juvenile and 5 adult male monkeys (macaca fascicularis) and blocked, sectioned, a ... | 1985 | 3904850 |
| pulmonary effects of acute vanadium pentoxide inhalation in monkeys. | an experimental study was conducted to investigate the hypothesis that changes in pulmonary function induced by vanadium pentoxide (v2o5) inhalation would be accompanied by evidence of pulmonary inflammation. sixteen adult, male cynomolgus monkeys were acutely exposed by whole-body inhalation of v2o5 dust at aerosol concentrations of 0.5 mg v2o5/m3 and 5.0 mg v2o5/m3, conducted at a 1-wk interval. comprehensive pulmonary function tests were performed 1 day after each inhalation exposure to detec ... | 1985 | 3907443 |
| microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent. | the potential of octenidine hydrochloride (win 41464-2) as a topical microbicide was measured both by in vitro death kinetics and reductions in numbers of bacteria on the skin of cynomolgus monkeys. semilogarithmic survival curves were plotted to measure the microbicidal activity of various concentrations of octenidine against staphylococcus aureus. the microbicidal activity of octenidine was also determined for staphylococcus epidermidis, proteus mirabilis, streptococcus pyogenes, klebsiella pn ... | 1985 | 3909955 |
| serum nca in bone marrow transplant recipients and its metabolism. | normal colon and granulocyte antigen (nca) in serum from 24 patients undergoing bone marrow transplantation (bmt), mostly for leukemic disease, was studied for a period of 0-60 days before/after transplantation. out of the 23 patients with a take, 20 acquired elevated serum nca. one patient had a rejection of the transplantation and never showed a rise of nca values. thirteen patients were studied in detail; 7 of them had an nca rise 1-4 days before take, 4 at the day of take and 2 patients 1-4 ... | 1985 | 3910975 |
| colonic mucin composition in primates. selective alterations associated with spontaneous colitis in the cotton-top tamarin. | heterogeneity of colonic mucin glycoprotein was examined in rectal mucosal biopsy specimens from a variety of primate species (saguinus oedipus, n = 18; macaca mulatta, n = 2; macaca fascicularis, n = 2; aotus trivirgatus, n = 2; saimiri sciureus, n = 2; and callithrix jacchus, n = 2). after initial separation of radiolabeled mucin and nonmucin glycoproteins solubilized from mucosal biopsy specimens, at least five labeled mucin components were found in monkey rectal mucosa in contrast to the six ... | 1985 | 3917260 |
| biological effect of pcbs, pcqs and pcdfs present in the oil causing yusho and yu-cheng. | male sprague-dawley rats were daily given orally for 22 days a regimen consisting of polychlorinated biphenyls (pcbs), 1 mg/day; polychlorinated quaterphenyls (pcqs), 1 mg/day; polychlorinated dibenzofurans (pcdfs), 10 micrograms/day; or a mixture of pcbs, pcqs and pcdfs (mix-1, 1 mg + 1 mg + 10 micrograms/day). female cynomolgus monkeys were daily administered pcbs (5 mg), pcqs (5 mg) or a mixture (mix-2) containing 5 mg pcbs + 20 micrograms pcdfs for 20 weeks. the pcbs, and pcdfs had the compo ... | 1985 | 3921369 |
| mamillary-body lesions and visual recognition in monkeys. | cynomolgus monkeys with complete bilateral destruction of the medial mamillary nucleus exhibited little, if any, deficit in object recognition, although they did show evidence of impairment in spatial memory. the pattern of effects thus resembled that found previously after either hippocampal ablations or transections of the fornix and suggests that, like such damage, mamillary-body damage alone is insufficient to produce the global amnesia attributed to it in clinical cases. | 1985 | 3921394 |
| cardiac output distribution and regional blood flow during hypocarbia in monkeys. | cardiac output distribution and regional blood flow were studied during hypocarbia independent of changes in ventilatory parameters. fifteen cynomolgus monkeys were anesthetized with methohexital sodium (8 mg/kg im) and hyperventilated through an endotracheal tube. hypocarbia at two levels, 28 +/- 1.8 and 17 +/- 0.6 torr, was achieved by a stepwise decreasing co2 flow into the semiclosed system. regional blood flow was determined with labeled microspheres. at each stage of experiments two sets o ... | 1985 | 3921515 |
| metabolism of arachidonic acid by macaque platelets. implications for studies on atherosclerosis. | the metabolism of [1-14c]arachidonic acid [( 1-14c]aa) by washed platelets from macaques and human subjects was investigated. the results were as follows: at substrate levels of 1 microm, similar amounts of prostaglandin e2 (pge2), prostaglandin f2 alpha (pgf2 alpha), prostaglandin d2 (pgd2), and thromboxane a2 (txa2), measured as thromboxane b2 (txb2), were produced from [1-14c]aa by platelets from rhesus, celebes black, and cynomolgus macaques and humans. an increase in the aa concentration fr ... | 1985 | 3924062 |
| immunoaffinity isolation of apolipoprotein e-containing lipoproteins. | discrete apolipoprotein e-containing lipoproteins can be identified when edta plasma is fractionated on columns of 4% agarose. the present study has demonstrated, by physical and metabolic criteria, that these apolipoprotein e-containing lipoprotein subclasses may be further isolated by immunoaffinity chromatography. whole plasma was first bound to an anti-apolipoprotein e immunoadsorbent prior to gel filtration on 4% agarose. after elution from the affinity column and dialysis, the bound fracti ... | 1985 | 3924105 |
| interference with the gonadotropin-suppressing actions of estradiol in macaques overrides the selection of a single preovulatory follicle. | we examined the role of the gonadotropin-suppressing effects of estradiol on the maturation of a single ovulatory follicle in cynomolgus monkeys (macaca fascicularis) by administering ovine antiestradiol antibodies during the mid through late follicular phase of the menstrual cycle. in each of three control animals, when the ovary containing the maturing follicle was removed during the late follicular phase, histological examination of the remaining ovary 10 days later revealed the presence of a ... | 1985 | 3926474 |
| x-ray localization of limbic structures in the cynomolgus monkey (macaca fascicularis). | the anterior/posterior (ap) and dorsal/ventral positions of 3 subcortical structures, the amygdala, the mamillary bodies, and the anterior commissure, were estimated with respect to the skull in a series of cynomolgus monkeys (macaca fascicularis). the distance from the external auditory meatus, from which stereotaxic coordinates are typically derived, to these structures was found to be highly variable. in contrast, radiography revealed that a skull landmark which forms part of the sphenoid bon ... | 1985 | 3928977 |
| acute trimethyltin intoxication in the monkey (macaca fascicularis). | adult cynomolgus monkeys were administered trimethyltin (tmt) iv in dosages ranging from 0.75 to 4.0 mg tmt/kg and observed for behavioral changes. animals were subsequently killed for light and electron microscopic examination. tmt showed a dose-related toxicity, with high dose animals (4.0 and 3.0 mg/kg) dying within 24 hr, and low dose animals (0.75 mg/kg) surviving without morphological effects. animals given 1.10 mg tmt/kg displayed a reproducible clinical course, characterized by tremor, h ... | 1985 | 3929430 |
| effects of toluene inhalation on behavior and expired carbon dioxide in macaque monkeys. | cynomolgus macaque monkeys received head-only exposure to 0, 100, 200, 500, 1000, 2000, 3000, and 4500 ppm toluene for 50 min while simultaneously tested for delayed matching-to-sample behavior, a test of cognitive functions. response time increased and accuracy of matching decreased at 2000 ppm or more of toluene, indicating an attentional deficit but not specific memory effects. behavioral indices exhibited monotonic concentration-related changes. expired carbon dioxide (co2), the most sensiti ... | 1985 | 3929433 |
| the effects of atropine, benactyzine, and physostigmine on a repeated acquisition baseline in monkeys. | a repeated acquisition procedure was used with cynomolgus monkeys to test the effects of one anticholinesterase (physostigmine) and two anticholinergic (atropine and benactyzine) compounds on learning and performance. learning was defined as the number of response chains (trials) required to meet a criterion of three consecutive chains at 90% accuracy or better. measures were the number of trials to criterion and the number of errors made. following learning, behavior was analyzed as performance ... | 1985 | 3933038 |
| comparison of arginase activity in red blood cells of lower mammals, primates, and man: evolution to high activity in primates. | arginase activity in red blood cells (rbc) of various mammalian species including man was determined. in nonprimate species, the activity generally fell below the level of detectability of the assay: less than 1.0 mumol urea/g hemoglobin per hr. activities in higher nonhuman primates were equal to or of the same order of magnitude as those in man (approximately 950 mumol/g hemoglobin per hr). rbc arginase deficiency with normal liver arginase activity has been shown to segregate as an autosomal ... | 1985 | 3936352 |
| natural history of penetrating ocular injury with retinal laceration in the monkey. | in one eye each of four cynomolgus monkeys, an 8-mm penetrating injury was made through the equator; there was retinal perforation with vitreous loss. none of the four eyes with this injury developed posterior vitreous detachment or retinal detachment during a follow-up period of 8 months to 1 year. another group of 26 monkeys had the same injury but also had 0.5 ml autologous whole blood injected into the vitreous at the time of injury. the eyes were examined weekly and enucleated at scheduled ... | 1986 | 3943726 |
| laser light-scattering study of the toxic effects of methylmercury on sperm motility. | an in vitro study was designed using the laser light-scattering technique to obtain further information on the dose-effect relationship of methylmercury on sperm motility. the technique provided a quantitative evaluation of sperm swimming speed. semen samples were collected from normal male macaca fascicularis monkeys by anal electroejaculation. methylmercury was added to aliquots of sperm suspensions in bww medium in doses of 10, 5, 2, and 1 ppm. after 3 hours, the relative speed was 35%, 59%, ... | 1986 | 3944015 |
| the effect of absence of the mother on the acquisition of phobic behaviour in cynomolgus monkeys (macaca fascicularis). | | 1986 | 3947314 |
| diet and vasectomy: effects on atherogenesis in cynomolgus macaques. | we report here the effect of a moderately atherogenic diet on the progression of atherosclerosis among cynomolgus macaques that were either vasectomized or sham vasectomized. both groups were compared to sham vasectomized monkeys fed a control monkey chow diet. as expected, slight hyperlipoproteinemia induced by the moderately atherogenic diet increased endothelial cell replication rates and resulted in the development of intimal lesions among sham vasectomized monkeys. unexpectedly, vasectomy r ... | 1986 | 3948976 |
| morphologic response of endometrium to a progesterone receptor antagonist, ru486, in monkeys. | fifteen castrate cynomolgus monkeys were assigned to one of two groups. all monkeys received estradiol (e2) capsules to mimic follicular phase e2 levels for development of a proliferative endometrium. in study i, three monkeys received ru486 on day 13 for 3 days; two others were given vehicle. on day 16, endometrium was removed. in study ii, the remaining ten monkeys received progesterone capsules, beginning on day 12, to form a secretory endometrium. on day 29, six monkeys were given ru486 and ... | 1986 | 3949027 |
| embryo cryopreservation in cynomolgus monkeys. | an improved knowledge of cryopreservation of primate embryos will have important research and clinical application. fifty-six 4- to 8-cell in vitro fertilized embryos were frozen in hepes-buffered tyrode's solution containing 1.5 m dimethylsulfoxide (dmso) and cooled at the rate of 0.3 degrees c/minute to -39 degrees c before being transferred into liquid nitrogen. embryos were rapidly thawed at room temperature for 2 minutes. dmso was diluted with medium in three steps at 5-minute intervals. of ... | 1986 | 3949040 |
| flash and pattern electroretinograms in normal and laser-induced glaucomatous primate eyes. | experimental glaucoma was produced in one eye of five cynomolgus monkeys with the argon laser delivering 100-200 50-mu spots at 1200-1500 mw power and 0.5 sec to 360 degrees of the mid-trabecular meshwork. monocular electroretinograms (ergs) were recorded prior to and 2, 3, and 4 mo following the laser treatment. in the laser-treated (glaucoma) eyes, normal flash ergs were observed using 1-hz stimulation; however, pattern ergs (pergs) elicited using steady-state counterphase modulation of a 0.51 ... | 1986 | 3949466 |
| experimental obstruction to aqueous outflow by pigment particles in living monkeys. | pigment particles (1 x 10(6)/microliters) isolated from the iris and ciliary body of enucleated cynomolgus monkey eyes were infused into the anterior chamber of seven living cynomolgus monkeys and aqueous humor outflow facility determined by the two-step constant-pressure perfusion technique. outflow facility acutely decreased 64% in the experimental pigment perfused eyes compared to a 76% increase in the sham-manipulated fellow eyes (p less than 0.001). however, when next measured 1 wk later, f ... | 1986 | 3949467 |
| noradrenergic and serotoninergic innervation of cortical, thalamic, and tectal visual structures in old and new world monkeys. | antisera directed against human dopamine-beta-hydroxylase and against serotonin were used to characterize the noradrenergic (na) and serotoninergic (5-ht) innervation of several cortical and subcortical visual areas in squirrel monkey (saimiri sciureus) and cynomolgus monkey (macaca fascicularis). few species differences were observed for either monoamine. cortical areas 17 and 18, as well as visual areas in the temporal and parietal lobe were found to exhibit regional specialization of both 5-h ... | 1986 | 3950077 |
| projections of thalamic gustatory and lingual areas in the monkey, macaca fascicularis. | the efferent projections of the parvicellular division of the ventroposteromedial nucleus of the thalamus (vmppc; thalamic taste area) were traced to cortex in macaca fascicularis by using tritiated amino acid autoradiography. labeled fascicles could be traced from vpmpc to two discrete regions of cortex. the primary efferent projection was located on ipsilateral insular-opercular cortex adjacent to the superior limiting sulcus and extended as far rostrally as the posterior lateral orbitofrontal ... | 1986 | 3950095 |
| gustatory responses in the nucleus tractus solitarius of the alert cynomolgus monkey. | multiunit and single neuron responses to taste stimuli in the nucleus tractus solitarius (nts) of alert cynomolgus monkeys were analyzed. intensity-response functions, including neural thresholds to glucose and quinine hcl, agreed well with psychophysical reports, implying that the cynomolgus monkey and human share the same dynamic range of sensitivity to prototypical taste stimuli. the nts is chemotopically organized: neurons most responsive to hcl are more common in the posterior gustatory are ... | 1986 | 3950684 |
| the hemostatic derangement produced by t-2 toxin in cynomolgus monkeys. | t-2 toxin, a mycotoxin produced by several strains of the genus fusarium, has been implicated as a cause of serious illness in both animals and man. hemorrhage is a feature of the syndromes which have been described. an ld20 dose of t-2 was administered im to adult cynomolgus monkeys. this resulted in prolongation of prothrombin and activated partial thromboplastin times and a decrease in multiple coagulation factors. these changes were detected within hours of toxin administration, were maximal ... | 1986 | 3952736 |
| icterus and amaurosis caused by lead poisoning in a cynomolgus monkey (macaca fascicularis). | the diagnosis and treatment of a case of lead poisoning in a cynomolgus monkey (macaca fascicularis) are described. the clinical signs were jaundice and amaurosis. clinicopathological findings suggested cholestasis. a tentative diagnosis of lead poisoning was made when basophilic stippling of erythrocytes was observed in a peripheral blood smear. the diagnosis was confirmed by finding a lead concentration of 2280 micrograms/litre in a venous blood sample. cage bars painted with red lead appeared ... | 1986 | 3952944 |
| experimental retinal detachment. xi. furosemide-inhibitable fluid absorption across retinal pigment epithelium in vivo. | rhegmatogenous retinal detachments were created in one eye of each of six cynomolgus monkeys. total vitrectomy alone was performed in the fellow eyes. the rate of disappearance of fluorescein sodium injected into the vitreous cavity was measured with kinetic vitreous fluorophotometry. intravitreal 10(-4)m probenecid was used to inhibit active outward transport of fluorescein. in eyes with retinal detachment, the rate of fluorescein loss from the vitreous cavity was decreased 44% and 22% followin ... | 1986 | 3954667 |
| experimental ocular onchocerciasis in cynomolgus monkeys. | infection of cynomolgus monkeys with microfilariae (mf) of onchocerca lienalis was studied as a model for human ocular onchocerciasis. normal monkeys and immunized monkeys were given intracorneal/subconjunctival, intracameral, or intravitreal injections of mf or bovine serum albumin (control). selected animals were given diethylcarbamazine citrate (dec) orally (15 mg/kg) daily after the ocular infection. following intravitreal challenge, living mf and fibrinous exudates were visible by slit-lamp ... | 1986 | 3957567 |
| blood characteristics of the crab-eating monkeys (macaca fascicularis) in bali island, indonesia: implication of water deficiency in west bali. | environmental effects on blood characteristics of macaques were examined by comparing several blood indices of the free-ranging crab-eating monkeys (macaca fascicularis) in two distinct regions of bali island, indonesia. the total plasma protein level and concentrations of creatinine and sodium ion were higher with macaques of teluk terima in the west part of bali island (dry area) than those in the central bali (wet area). results indicated that water deficiency in the dry area significantly af ... | 1986 | 3959063 |
| comparison of the effects of testosterone and dihydrotestosterone on the behavior of male cynomolgus monkeys (macaca fascicularis). | to compare the behavioral effects of testosterone propionate (tp) and diyhdrotestosterone propionate (dhtp) at doses producing plasma levels of androgens within the physiological rage, observations were made on 4 castrated male cynomolgus monkeys during successive 4-week treatment periods while they received 25, 50, 100, 200, 400 and 800 micrograms of either tp or dhtp sc/day in counterbalanced order. males were tested with each of the same 4 female partners (16 pairs, 1024 1-hr behavior tests). ... | 1986 | 3961012 |
| vaccination against schistosoma mansoni with purified surface antigens. | two surface antigens were isolated from young or adult schistosomes by affinity chromatography with monoclonal antibodies. vaccination with an antigen having a molecular weight of 155,000 gave partial protection against challenge in some batches of mice and in a group of cynomolgus monkeys. vaccination with an antigen having a molecular weight of 53,000 gave similar levels of protection in mice. the results demonstrate that protection can be obtained with single antigens, but the precise require ... | 1985 | 3966161 |
| ultrastructure of the dorsal motor nucleus of the vagus nerve in monkey with a comparison of synaptology in monkey and cat. | neurons of the dorsal motor nucleus of the vagus nerve were studied following injections of horseradish peroxidase into the vagus nerve in a monkey (macaca fascicularis). in frozen sections, the dorsal motor nucleus appeared to be completely filled by labeled medium-sized (20-30 micron in long axis) neurons. labeled dendrites from these neurons often extended outside the borders of the nucleus into the nucleus of the tractus solitarius. in 1 micron thick plastic sections and ultrathin sections o ... | 1985 | 3968233 |
| cardiovascular effects of losulazine hydrochloride, a peripheral norepinephrine-depleting agent, in nonhuman primates. | the cardiovascular actions of losulazine hydrochloride, a peripheral norepinephrine-depleting agent in rodents, have been determined in conscious cynomolgus monkeys. acute oral administration of losulazine at 0.1, 1, 10 and 30 mg/kg evoked dose-related hypotensive responses in the absence of significant alterations of heart rate. although variable, the acute hypotensive effects of losulazine were associated with both reductions of peripheral vascular resistance and reductions in cardiac output. ... | 1985 | 3968642 |
| an 85-day study of butylated hydroxyanisole in the cynomolgus monkey. | groups of 8 cynomolgus monkeys (macaca fascicularis) were given 500, 125 and 0 mg/kg body wt butylated hydroxyanisole (bha) by gavage in corn oil 5 times/week for 20 days, after which the high dose was halved. no significant adverse clinical signs nor abnormal fibroscopic observations were noted before the experiment was terminated at 85 days. blood levels of glucose, albumin, chloride, red blood cells (rbcs), hemoglobin (hgb), hematocrit (hct) and mean corpuscular hemoglobin (mch) were altered ... | 1985 | 3971351 |
| vestibular nuclei activity and eye movements in the alert monkey during sinusoidal optokinetic stimulation. | in the alert monkey (macaca fascicularis) vestibular nuclei neurons and eye movements were recorded during sinusoidal optokinetic stimulation in the horizontal plane at frequencies between 0.02-3.3 hz. maximal stimulus velocity was generally kept constant at 40 deg/s, except for frequencies above 1 hz. eye movements showed a nystagmus-like pattern up to 0.2 hz with a gain (change in eye position/change in cylinder position) greater than 0.8; at frequencies above 1 hz the gain dropped to 0.35 at ... | 1985 | 3972036 |
| a description of intra-amygdaloid connections in old world monkeys. | the intrinsic amygdaloid connections of the cynomolgus monkey were investigated using the autoradiographic method. additional evidence concerning the origin of some intra-amygdaloid connections was provided by a series of rhesus monkeys with injections of horseradish peroxidase (hrp) in the amygdaloid complex. the experiments indicated that each of the major amygdaloid nuclei possesses a unique, organized set of intrinsic projections. furthermore, there were large differences in the magnitude of ... | 1985 | 3972039 |
| shunt fascicles in the gastric myenteric plexus in five species. | thick nerve bundles, called shunt fascicles, lie in the myenteric plexus of the stomach in guinea pig, rabbit, cat, opossum, and cynomolgus monkey. they enter the stomach at the cardia, either as extensions of the esophageal myenteric plexus or of vagal branches to the caudal esophagus, and radiate toward the greater curvature. they bypass ganglia in the orad part of the stomach but give off branches to ganglia in more caudad parts. they are more abundant in the gastric fundus and body than in t ... | 1985 | 3972223 |
| a freeze-fracture study on epididymal and ejaculate spermatozoa of the monkey (macaca fascicularis). | spermatozoa from four epididymal regions and from the ejaculate of the monkey, macaca fascicularis, always present the same particle organization for a given sample. the plasmalemma contains homogeneously distributed, 7-8 nm size, pf-face, particles throughout the head, midpiece and principal piece. a unique, particle arrangement occurs in the plasmalemmal, pf-face in spermatozoa from the proximal levels of the body of the epididymis only. square arrays of 4-6 nm size, pf-face plasmalemmal parti ... | 1985 | 3973955 |
| influence of housing conditions on pregnancy outcome in cynomolgus monkeys (macaca fascicularis). | female cynomolgus monkeys (macaca fascicularis) were kept under 3 different housing conditions: individually in type a cages (45 x 45 x 60 cm), individually in type b cages (70 x 70 x 100 cm) and as couples in type b cages. primigravida did not show early embryonic mortality, differing significantly from 11.5% early losses in multigravida. early embryonic mortality was not affected by housing condition. further reproductive failure rates did not differ significantly for primigravid (18.5%) and m ... | 1985 | 3974197 |
| progesterone-mediated suppression of estradiol receptors in cynomolgus macaque cervix, endometrium and oviduct during sequential estradiol-progesterone treatment. | we used sequential treatment with implants of estradiol (e2) and progesterone (p) to create varied hormonal states in a group of spayed cynomolgus macaques. the reproductive tracts were removed, and nuclear and cytosolic estrogen receptors were analyzed in the cervical mucosa, endometrium, and oviducts. nuclear receptor quantities were greater in tissues of e2-treated monkeys than in tissues of spayed animals. sequential p treatment, even in the presence of continuous e2, decreased the amounts o ... | 1985 | 3974227 |
| flicker electroretinograms and visual evoked potentials in the evaluation of laser flash effects. | electroretinograms (erg's) and visual evoked potentials (vep's) were recorded from four cynomolgus monkeys in response to a sinusoidally flickering argon laser beam (514 nm) producing a 50-micron spot on the fovea. super-position of a 20-hz train of six pulses of q-switched (120 ns) frequency-doubled neodymium laser light (532 nm) at "safe" exposure energies in 250 ms had no significant effects on the erg (p greater than 0.05). the vep was disrupted significantly (p less than 0.001) but demonstr ... | 1985 | 3976833 |
| pharmacokinetic analysis of intravitreal ceftriaxone in monkeys. | ocular toxic effects of intravitreally injected ceftriaxone sodium and its rate of clearance after a single dose were studied in rhesus and cynomolgus monkeys. doses of 2, 2.5, and 3 mg/0.1 ml were injected into the vitreous cavity. electroretinograms performed 15 minutes, 24 hours, one week, and two weeks after injection were not significantly different from preinjection electroretinograms. lens opacification occurred in one eye receiving 2.5 mg of ceftriaxone. histopathologic findings in the r ... | 1985 | 3977664 |
| q-switched neodymium-yag laser trabeculopuncture in monkeys. | in nine cynomolgus monkeys, trabeculopuncture was performed with a q-switched neodymium-yag laser, using a pulse energy of 5 to 7 millijoules and an exposure time of 14 nanoseconds. a penetration into schlemm's canal was successfully achieved with two to four pulses; this penetration was accompanied by intraocular pressure (iop) reduction and blood reflux into the anterior chamber. however, after eight days, iop returned to baseline level, while white tissue was observed gonioscopically to fill ... | 1985 | 3977666 |
| experimental retinal detachment. viii. retinochoroidal horseradish peroxidase diffusion across the blood-retinal barrier. | unilateral rhegmatogenous retinal detachments in 13 cynomolgus monkeys were studied with horseradish peroxidase (hrp). when injected subretinally in six eyes, hrp did not diffuse anteriorly into the sensory retina and penetrated posteriorly through the zonulae occludentes of the retinal pigment epithelium (rpe) in only two eyes. in seven eyes, tracer was detected after intravitreal hrp injection throughout the sensory retina, the basal lamina of retinal blood vessels, and the subretinal space, b ... | 1985 | 3977697 |
| ovariectomy, social status, and atherosclerosis in cynomolgus monkeys. | evidence is contradictory regarding the effects of natural or surgical menopause on "female protection" against coronary artery atherosclerosis. we evaluated atherosclerosis, plasma lipids, blood pressure, and carbohydrate tolerance in 21 ovariectomized and 23 intact female cynomolgus macaques fed a moderately atherogenic diet for 30 months. we also evaluated the influence of social dominance status, with particular emphasis on a possible relationship with ovarian endocrine function. atheroscler ... | 1985 | 3977777 |
| central distribution of efferent and afferent components of the pudendal nerve in macaque monkeys. | central distribution of efferent and afferent components of the pudendal nerve was studied by the horseradish peroxidase (hrp) method in 13 macaque monkeys, i.e., in nine japanese monkeys (macaca fuscata), two rhesus monkeys (macaca mulatta), and two crab-eating monkeys (macaca fascicularis). the enzyme was applied to the central cut end of the pudendal nerve; then the monkeys were allowed to survive for 36 to 72 hr. retrogradely labeled neuronal cell bodies of pudendal motoneurons constituted a ... | 1985 | 3980767 |
| normal serum biochemical, hematological, and ekg parameters in anesthetized adult male macaca fascicularis and macaca arctoides. | selected serum enzymes, cholesterol, triglycerides, glucose, uric acid, protein, albumin, bilirubin, bun, hematology, and electrocardiograms (ekg) were obtained from adult male cynomolgus (macaca fascicularis) and adult male stumptailed (macaca arctoides) macaques. serum alkaline phosphatase, uric acid, albumin, bilirubin, mean corpuscular hemoglobin (mch), mean corpuscular volume (mcv) and monocytes were significantly lower in the cynomogus monkeys. this relationship was reversed for serum leve ... | 1985 | 3981960 |
| observations on facial nociception in a monkey after destruction of the rostral part of the trigeminal sensory nuclear complex. | facial sensibility was assessed in a cynomolgus monkey in whom the trigeminal main sensory nucleus and the rostral part of the trigeminal nucleus oralis on one side had been destroyed. the animal responded equally to noxious mechanical stimuli applied to the two sides of the face; no deficiency in nociception could be detected. this finding suggests that the synaptic connections made by nociceptor afferents from the face in rostral parts of the trigeminal sensory nuclear complex are not essentia ... | 1985 | 3982839 |
| [persistent pupillary membranes in a cynomolgus monkey]. | three thousand and five apparently healthy cynomolgus monkeys (macaca fascicularis) were examined for the finding of the anterior part of the oculi by using an ophthalmoscope. one drop of the mixed solution of 0.5% tropicamide and 0.5% phenylephrine hydrochloride was instilled into each eye of the animal. then, those monkeys were anesthetized with ketamine-hc1 at the dose level of 10 mg/kg b. w.. one monkey had opaque membranes of tan to brown color, extending from some part of collarette of the ... | 1985 | 3987825 |
| evidence for a non-steroidal angiotropic factor from the primate corpus luteum: stimulation of endothelial cell migration in vitro. | after luteal cells from 7 midluteal phase cynomolgus monkeys were cultured for 72 h, luteal conditioned media were found to contain angiotropic activity that stimulated endothelial cell migration in vitro, using a 48-microwell chemotaxis assembly. the number of endothelial cells that migrated through 8 micron-pore polycarbonate membranes in 2 h was three-fold greater (p less than 0.01) with luteal cell-conditioned vs identical unconditioned media. pre-treatment of luteal cultures with hcg, fsh, ... | 1985 | 3991594 |
| retroperitoneal fibromatosis and acquired immunodeficiency syndrome in macaques. pathologic observations and transmission studies. | a peculiar fibroproliferative syndrome called retroperitoneal fibromatosis (rf) has been observed in macaca nemestrina, macaca mulatta, macaca fascicularis, and macaca fuscata at the washington regional primate research center. rf is characterized by the aggressive proliferation of highly vascular fibrous tissue subjacent to the peritoneum covering the ileocecal junction and associated mesenteric lymph nodes. in the early, proliferative phase of the disease, most of the fibroblastlike cells cont ... | 1985 | 3993741 |
| architecture of associations of minor salivary gland ducts and lymphoid follicles in macaca fascicularis. an ultrastructural study. | previous light-microscopic and ultra-immunohistochemical tracer studies revealed the existence of an independent local immune response of the simian oral mucosa. this local response is attributed to the presence of minor salivary gland (msg) duct-related lymphoid tissue. semithin sections from a total of 263 epon-embedded tissue blocks from the labial and buccal mucosae of seven monkeys, macaca fascicularis, were analysed light-microscopically, and 10 suitable msg duct/follicle assemblies were i ... | 1985 | 3995540 |
| localization of the synthetic progestin 3h-org 2058 in neurons of the primate brain: evidence for the site of action of progestins on behavior. | the location of neurons that concentrate progestin in the brains of female cynomolgus monkeys was mapped by autoradiography using the specific synthetic progestin receptor ligand 3h-org 2058. three females were ovariectomized and treated with estrogen (20 micrograms estradiol benzoate daily for 7 days), and one of them was also pretreated with progesterone. each received an i.v. injection of 1 mci 3h-org 2058 and was killed 1 hour later. thaw-mount autoradiograms revealed intense accumulation of ... | 1985 | 3998214 |
| transneuronal degeneration in the heart and gastro-oesophageal junction in the monkey (macaca fascicularis) following unilateral vagotomy. | this study describes, at the ultrastructural level, the transneuronal degeneration that occurs in the atrial and gastro-oesophageal ganglia of the monkey following unilateral vagotomy. one day after unilateral vagotomy, some postganglionic neurons showed an overall increase in electron density, with the dendrites darkening first. three days after the operation, the dendrites appeared jet black and their intracytoplasmic organelles were hardly distinguishable except for some pale mitochondria. th ... | 1985 | 4004117 |
| experimental retinal detachment. ix. aqueous, vitreous, and subretinal protein concentrations. | unilateral rhegmatogenous retinal detachments were created in seven cynomolgus monkeys. six months later, aqueous, vitreous, and subretinal fluid protein concentrations were measured. in fellow eyes with vitrectomy alone, mean aqueous and vitreous protein concentrations were 0.28 and 0.23 mg/ml, respectively. in eyes with retinal detachments, mean aqueous, vitreous, and subretinal protein levels were 1.46, 2.66, and 4.74 mg/ml, respectively. eyes with a large retinal hole (greater than or equal ... | 1985 | 4004625 |
| effects of 2.45-ghz microwaves on primate corneal endothelium. | both eyes of anesthetized cynomolgus monkeys (macaca fascicularis) were irradiated with 2.45-ghz microwaves, either pulsed or continuous wave. in vivo corneal endothelial abnormalities were observed by specular microscopy and confirmed through histologic techniques after a 16- to 48-hour postexposure period. pulsed microwaves with an average power density of 10 mw/cm2 (equivalent to a specific absorption rate (sar) = 2.6 w/kg) produced these effects, while levels of 20-30 mw/cm2 (equivalent to a ... | 1985 | 4004950 |
| the fate of chronically consumed caffeine in the monkey (macaca fascicularis). | the metabolic fate of chronically administered caffeine was examined in monkeys. caffeine and equal parts of citric acid were added to the drinking water of four female monkeys (macaca fascicularis). the concentration was gradually increased over a 10-week period to 0.35 mg/ml for three of the monkeys. a monkey that was lactating, but had no infant, was exposed to caffeine in the drinking water at a concentration of 0.30 mg/ml. at these doses, administered for up to 50 weeks, there were no overt ... | 1985 | 4007312 |
| effect of diet on blood lead concentration in the cynomolgus monkey. | infant cynomolgus monkeys (macaca fascicularis) were reared from birth in an infant primate nursery and dosed with lead acetate (2 mg pb/kg body wt/day) from approximately 100 days of age. the monkeys were switched from an infant formula diet to a diet of primate chow and water at 460 days of age. beginning at approximately 935 days of age, various diets were fed in the following order: infant formula plus a restricted amount of primate chow, infant formula only, infant formula plus cellulose fi ... | 1985 | 4007313 |
| effect of repeated anterior chamber perfusion on aqueous flow in the cynomolgus monkey. | no differences were found between fluorophotometrically determined aqueous flow rates in cynomolgus monkeys having vs not having undergone prior repeated anterior chamber perfusion. this suggests that: repeated perfusion does not produce a progressive decline in the rate of aqueous formation; and the repeatedly perfused monkey eye can be validly used in studies of aqueous formation. | 1985 | 4008198 |
| ultrastructure of the primate carotid body: a morphometric study of the glomus cells and nerve endings in the monkey (macaca fascicularis). | the carotid body of the monkey (macaca fascicularis) was studied at both the light and electron microscopic levels in an effort to provide a detailed quantitative characterization of this chemoreceptor organ in the primate. structurally, the monkey carotid body was organized into lobules of from three to eight glomus cells (in section) and their ensheathing supporting cells. interspersed among the lobules was abundant connective tissue stroma, fibroblasts and mast cells. fenestrated capillaries, ... | 1985 | 4009212 |
| a case of acardiac anomaly in the cynomolgus monkey (macaca fascicularis): a complication of monozygotic monochorial twinning. | a case of acardius acephalus in a macaca fascicularis is reported. this congenital anomaly occurs only in multiple-birth gestations (most commonly monozygotic twins). artery-to-artery and vein-to-vein anastomoses appear to be a constant feature. this condition is very rare in man and probably even more so in monkeys. classification and theories on etiology are discussed. | 1985 | 4009692 |
| the midbrain periaqueductal gray: a brainstem structure involved in vocalization. | experiments were performed on one macaca fascicularis and three macaca mulatta monkeys. electrical stimulation of the midbrain periaqueductal gray (pag) elicited phonation closely resembling that naturally produced by such animals. electromyographic (emg) recordings from laryngeal, thoracic, tongue, and facial muscles showed increased levels of activity following pag stimulation. recordings were made from single neurons located within the pag in one monkey. these neurons increased their firing r ... | 1985 | 4010254 |
| an indwelling cannula system for the primate eye. | an indwelling cannula system was designed as an instrument for chronic drug infusion into the vitreous cavity and tested in the cynomolgus monkey eye with repeated injections or continuous infusion using a pumping device. the cannula was passed through the pars plana and its tip situated in the vitreous cavity close to the macular area. clinical observations up to 18 months did not reveal any adverse effects due to implantation. histopathological observations from 1 week to 18 months after surge ... | 1985 | 4010336 |
| structural and hemodynamic response of peripheral arteries of macaque monkeys to atherogenic diet. | the arteries of monkeys given atherogenic diets develop marked intimal thickening and medial thinning, but luminal size apparently changes minimally. the hemodynamic significance of the atherosclerotic changes is therefore uncertain. to evaluate vascular function in atherosclerotic arteries, we studied the hind-limb vessels of adult male rhesus and cynomolgus monkeys to assess the structural and hemodynamic responses to an atherogenic diet given for about 1.5 years or for much longer periods (6. ... | 1985 | 4015507 |
| in vitro 16 alpha-hydroxylation of progesterone by testes of crab-eating monkey (macaca irus): a characteristic of primates? | radioactive 16 alpha-hydroxyprogesterone was obtained as one of the major metabolites of [14c]pregnenolone and progesterone by testicular homogenates of an adult crab-eating monkey (macaca irus). 16 alpha-hydroxylation of progesterone occurred by incubation of testes of men and and the monkey, but not by those of rodents and other vertebrates examined. | 1985 | 4017546 |
| the optically determined corneal and anterior chamber volumes of the cynomolgus monkey. | we described an optical method of measuring corneal volume and employed the optical method of johnson et al. for measuring the volume of the anterior chamber in cynomolgus monkey. in 12 normal monkey eyes, the corneal volume was found to be 40.4 +/- 2.3 microliter (mean +/- s.e.) and the anterior chamber volume was 101.8 +/- 4.2 microliter (mean +/- s.e.). | 1985 | 4017622 |
| [abnormal findings in the ocular fundi of colony-born cynomolgus monkeys]. | the ocular fundi of 1,151 apparently healthy colony-born cynomolgus monkeys (macaca fascicularis) ranging in age from newborn to 19 years were examined using an ophthalmoscope. two hundred and thirty-eight abnormal findings were recorded in 219 of the 1,151 monkeys. of these, 23 were related to the optic disc and 115 to the retinal vessels. of the remaining 100 abnormal findings, 91 were retinal degenerations and 9 were retinal hemorrhages. the 23 optic disc abnormalities consisted of 3 cases of ... | 1985 | 4018147 |
| [measurement of serum prolactin and the effect of ketamine anesthesia on serum prolactin levels in cynomolgus monkeys (macaca fascicularis)]. | the effect of an anesthetic, ketamine, on the serum prolactin level was examined in wild-originating female cynomolgus monkeys (macaca fascicularis) imported from south east asia. serum prolactin levels were measured by the homologous radioimmunoassay system which was developed for human prolactin. the validity was confirmed by using an extract of pituitary gland from a female cynomolgus monkey as well as serum and amniotic fluid from a pregnant monkey. additionally, serum luteinizing hormone (l ... | 1985 | 4018149 |
| the thalamic connections with medial area 6 (supplementary motor cortex) in the monkey (macaca fascicularis). | the interrelationship of medial area 6 (supplementary motor area) with the thalamus was investigated by means of anterograde and retrograde tracing methods. nine monkeys were prepared for autoradiography or histochemistry with the marker hrp conjugated to the lectin wheat germ agglutinin. three of the monkeys received injections into the precentral cortex for comparison. previous observations were confirmed that the thalamic relays to the motor areas are organized as crescent-shaped lamellae whi ... | 1985 | 4018201 |
| auditory brainstem and middle latency responses in non-human primates. | auditory brainstem (abr) and middle latency responses (mlr) were obtained from each ear in 8 crab-eating macaques, 4 white-handed gibbons, 4 siamangs and 2 orangutans. macaques ranged in age from 5 days to 15 years with the 6 older animals in age-matched, male-female pairs. from each animal, latency-intensity functions were obtained and multiple mlr recordings were measured at 60 and 70 db. latency-intensity functions, interwave intervals, thresholds and percent detectability were calculated for ... | 1985 | 4019328 |
| genetic control of the cynomolgus monkey breeding colony by the use of blood groups. | | 1985 | 4021179 |