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pyrimidine nucleoside phosphorylase from haemophilus influenzae. 1978308598
purulent pericarditis in children.acute purulent pericarditis was treated successfully in five children between the ages of 27 months and 11 1/2 years during the past 5 years. the responsible organism was hemophilus influenzae, type b, in two cases and meningococcus, pneumococcus, and coagulase-positive staphylococcus aureus in one case each. no primary source of infection could be identified in two patients. a high index of suspicion, combined with immediate echocardiograms and pericardiocentesis, led to the diagnosis. immediat ...1978308705
purine reutilization in phytohemagglutinin-stimulated human t-lymphocytes. 1978308885
anatomy of the surface of the articular disk of the temporo-mandibular articulation in man, seen with the scanning microscope. 1978308903
genetic control of the content and avidity of hapten-binding b lymphocytes in mouse spleen. 1978308926
characterization and mitogenic activity of haemophilus influenzae type b capsular polysaccharide.studies were conducted on the characterization of haemophilus influenzae type b polysaccharide (hitb-ps) and its mitogenic activity upon peripheral lymphocytes. this capsular polysaccharide was found to contain hexosamines and hexoses in addition to the main components of ribose and ribitol phosphate. the molecular weight of hitb-ps was determined as 585,000. the affinity constant of hitb-ps to unfractionated lymphocytes was 3.13 x 10(3) m-1 with 1.11 x 10(4) binding sites per cell. hitb-ps was ...1978308927
influenzal pneumonia: early appearance of cross-reactive t cells in lungs of mice primed with heterologous type a viruses.mice were first primed with a type a or a type b influenza virus and then challenged intranasally at least 1 month later with another type a virus. potent cytotoxic t cell populations were found in lung, and effector t cell function was also demonstrated in blood, spleen and mediastinal lymph nodes. lymphocytes isolated from all of these anatomical sites were active against target cells infected with the same, or with serologically different, type a influenza viruses. also, prior exposure to ano ...1978308930
prevalence of ampicillin- and chloramphenicol-resistant strains of haemophilus influenzae causing meningitis and bacteremia: national survey of hospital laboratories. 1978308974
role of the h-2 complex in induction of t helper cells in vivo. i. antigen-specific selection of donor t cells to sheep erythrocytes in irradiated mice dependent upon sharing of h-2 determinants between donor and host.when purified cba lymph node t cells were mixed with sheep erythrocytes (src) and filtered from blood to lymph through irradiated syngeneic mice for 1-2 days, the donor cells lost their capacity to stimulate anti-src responses by cba b cells; the response to a third-party antigen (horse erythrocytes) was unaffected and active suppression was not involved. this process of specific negative selection to src also occurred when semiallogeneic mice were used as filtration hosts. by contrast, when all ...1978308981
influenza virus infection in newborn rats: a possible marker of attenuation for man.the growth of parent influenza viruses a/england/939/69 and a/pr/8/34, and clones 6, 7, and 64c, derived by recombination, was studied in newborn rats. using an inoculum of 10(4.0) eid50, influenza virus a/england/939/69 produced the highest titres of virus in rat turbinates at 48 hours after inoculation; clones 6 and 7 and a/pr/8/34 grew to lower titres; and clone 64c grew to the lowest titre. these differences were less apparent when 10(2.0) eid50 of virus was used as an inoculum, and rats wer ...1978308996
apparatus for uniaxial testing of soft human tissues in vitro. 1978309051
periorbital cellulitis in children. 1978309105
[cefuroxim, a new beta-lactamase stable cephalosporin].in vitro activity of cefuroxime, a new cephalosporin stable to bacterial beta-lactamases, was compared with that of cefalothin and other cephalosporins by serial dilution test in more than 600 bacterial strains. cefuroxime was more active than cefalothin on most strains of gram negative bacilli (except salmonella species) and also on most strains of cefalothin-resistant bacteria. in comparison to cefalothin, cefoxitin and cefamandol, cefuroxime exerted the strongest activity on meningococci, str ...1978309178
cp-45,899, a beta-lactamase inhibitor that extends the antibacterial spectrum of beta-lactams: initial bacteriological characterization.cp-45,899 {3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 4,4-dioxide, [2s-(2alpha,5alpha)]} is an irreversible inhibitor of several bacterial penicillinases and cephalosporinases. in the presence of low concentrations of cp-45,899, ampicillin and other beta-lactams readily inhibit the growth of a variety of resistant bacteria that contain beta-lactamases. cp-45,899 used alone displays only weak antibacterial activity, with the notable exception of its potent effects on ...1978309306
role of immunity in the clearance of bacteremia due to haemophilus influenzae.the role of antibodies to capsular and somatic antigens in the clearance of haemophilus influenzae was investigated by active and passive immunization. the clearance index (k) and the proportion of strain b organisms cleared 30 min after intravenous administration (deltay30) were greater in eight-week-old actively immunized rats (k = 0.693, deltay30 = 4.07) than in nonimmune animals (k = 0.075, deltay30 = 0.95)(p less than 0.025 for all); however, clearance correlated imprecisely with titers of ...1978309494
congenital vesicular eruption caused by haemophilus influenzae type b.we report a case of perinatal infection that we believe is the first documented report of a congenital vesicular eruption due to haemophilus influenzae type b and the second report of puerperal sepsis with this organism. a vesicular eruption was noted at birth on an infant delivered at 37 weeks following 34 hours' premature rupture of membranes. gram-negative rods were seen on gram stain of vesicular fluid, and h. influenzae type b grew on cultures of vesicular fluid. the mother sustained postpa ...1978309588
many bacterial species are mitogenic for human blood b lymphocytes.thirty bacterial species were tested for their ability to stimulate to increased dna synthesis in human blood lymphocytes. a definite stimulation was obtained with eighteen bacterial species. for three of these species ten different strains of each were tested, and all increased dna synthesis. the maximum response was after 3--4 days of culture, suggesting a mitogenic effect. this was confirmed by the induction of polyclonal antibody production shown by a plague assay, which was positive for nin ...1978309629
two cases of septicemia caused by noncapsulated strains of haemophilus influenzae. 1978309630
hemophilus influenzae f cellulitis with bacteremia, peritonitis, and pleuritis in an adult with nephrotic syndrome.hemophilus influenzae f was responsible for cellulitis with bacteremia, pleuritis, and peritonitis in an adult patient with the nephrotic syndrome. the patient rapidly responded to ampicillin. h influenzae f has previously been rarely found to cause pleuritis and bacteremia, but has not been reported as a cause of cellulitis or primary peritonitis. patients with the nephrotic syndrome are prone to serious infection with encapsulated bacteria. the relative frequency of infection with the various ...1978309658
bulging (sagging) fissure sign in hemophilus influenzae lobar pneumonia.a bulging fissure sign was noticed on chest roentgenogram in a patient with h influenzae pneumonia. this sign is usually associated with klebsiella pneumonia and has also been seen in pneumococcal and plague pneumonia, tuberculosis, mass lesions of the lung, and large lung abscesses. this is thought to be the first report of a bulging fissure sign associated with pneumonia due to h influenzae.1978309660
haemophilus influenzae sepsis in the premature infant. 1978309717
haemophilus influenzae infections. 1978309718
radiological case of the month. 1978309719
bacteremic haemophilus influenzae genitourinary tract infections in adults.six cases of bacteremia associated with genitourinary (gu) tract infections in adults due to haemophilus influenzae occurred during a 42-month period at the health sciences centre in winnipeg, canada. four cases were associated with pregnancy or abortion, one with acute salpingitis, and one with urinary tract manipulation. four of the five strains available for serotyping were nontypable. clinical conjunctivitis was present in one patient, and infants born to two other patients developed purulen ...1978309754
further studies on the immunology of the infant rat experimental model of haemophilus influenzae type b meningitis. 1978309766
meningitis caused by hemophilus influenzae type c. 1978309935
treatment of otitis media caused by hemophilus influenzae: evaluation of three antimicrobial regimens.ninety young children with otitis media, proven by tympanocentesis culture to be due to hemophilus influenzae, were treated in a prospective double-blind study with one of three antimicrobial regimens: ampicillin, erythromycin ethylsuccinate, or erythromycin ethylsuccinate with concomitant trisulfapyrimidines. results of efficacy evaluation indicated that the combination was as effective as ampicillin and statistically superior to erythromycine alone. of the strains of h influenzae identified, 1 ...1978310164
evaluation of the indirect hemagglutination technique for study of trichomonas vaginalis infections, particularly in men.the indirect hemagglutination (iha) technique was evaluated for use in the serologic study of infection with trichomonas vaginalis. the iha test showed that sera from 88% of women attending a venereal disease clinic had antibody to t. vaginalis. the antibody frequency and titers were highest in women who had documented infections due to t. vaginalis. serologic and cultural evidence of recent or active trichomonal infection was found in 11% of 85 men who had nongonococcal urethritis, but was abse ...1978310166
increased resistance to established tumor metastases after elimination of thymus - t-cell mediated suppression. 1977310170
clavulanic acid, a novel inhibitor of beta-lactamases.clavulanic acid, z-(2r,5r)-3-(beta-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0] heptane-2-carboxylic acid, has been shown to be an effective inhibitor of the beta-lactamases of the richmond types ii, iii, iv, and v. inhibition is a time-dependent reaction and is irreversible. clavulanic acid had poor antibacterial activity against staphylococcus aureus, enterobacteriaceae, and pseudomonas aeruginosa, with minimal inhibitory levels greater than 25 mug/ml. it did inhibit the majority of nei ...1978310279
minimum bactericidal concentration of sulfamethoxazole-trimethoprim for haemophilus influenzae: correlation with prophylaxis.the inability of sulfamethoxazole-trimethoprim (sxt) to eradicate haemophilus influenzae nasopharyngeal carriage in all asymptomatic patients in closed populations was examined in vitro. a broth medium was adapted for susceptibility testing of h. influenzae which permitted us to determine minimum inhibitory concentrations and minimum bactericidal concentrations (mbcs). the minimum inhibitory concentrations were all low, but the mbcs were bimodally distributed. trimethoprim alone or the combinati ...1978310281
adult haemophilus influenzae type b vertebral osteomyelitis: a case report and review of the literature.osteomyelitis in adults due to haemophilus influenzae is exceedingly rare. we report a case of h. influenzae type b vertebral osteomyelitis in an adult. review of the english literature reveals one other adult patient with h. influenzae osteomyelitis, and sporadic pediatric cases. although a variety of predisposing host resistance factors have been postulated to account for this infection, the deficiency responsible for adult infection remains undelineated. bone biopsy is mandatory for diagnosis ...1978310376
enzyme-linked immunosorbent assay for detection and quantitation of capsular antigen of haemophilus influenzae type b.an enzyme-linked immunosorbent assay was developed to detect the presence of the ribose-ribitol phosphate capsular antigen of haemophilus influenzae type b in laboratory and clinical specimens. the assay is simple, sensitive, specific, and quantitative and should prove to be of value in the diagnosis and management of h. influenzae infections.1978310425
[haemophilus influenzae antibodies in the body fluid]. 1978310481
the role of pre-replication and post-replication processes in mutation induction in haemophilus influenzae by n-methyl-n'-nitro-n-nitrosoguanidine.studies were carried out on the repair and fixation of premutational damage induced in haemophilus influenzae by n-methyl-n'-nitro-n-nitrosoguanidine (mnng). the studies employed a temperature-sensitive dna elongation mutant (dna9) and its combinations with mutants defective in pyrimidine dimer excision (uvr1, uvr2) and in recombination (rec1). the dna9 mutant is shown to be leaky, allowing about 1% of the normal rate of dna synthesis at the restrictive temperature. repair of premutational lesio ...1978310510
clinical implications of preseptal (periorbital) cellulitis in childhood.the available hospital records of all pediatric patients diagnosed as having periorbital, preseptal or orbital cellulitis over a five-year period were reviewed and compared to previously reported series. only two of 39 patients had orbital cellulitis. the 37 patients with preseptal cellulitis had two characteristic clinical presentations. twenty-two children had local trauma, abscesses, insect bites, or impetigo as the inciting event for their cellulitis. infection was usually caused by staphylo ...1978310537
meningitis due to haemophilus influenzae other than type b: case report and review.a 4-month-old female infant with meningitis caused by haemophilus influenzae type f had a hospital course complicated by sterile subdural effusions and persistent neurologic abnormalities. one year later she was normal in all respects. the infant's mother had serum bactericidal antibodies to h. influenzae type b but not to type f. during recovery the patient had no bactericidal antibodies to type b, and the type f organism could not be maintained in her serum. review of the literature identified ...1978310538
haemophilus influenzae type d pneumonia. 1979310640
experimental and clinical immunopathology of middle ear transplantation.on the basis of experimental data the concept of immuno-tolerance in allograft-tympanoplasty is discussed. immunological interference in human tympanic membrane grafts has been demonstrated by means of t-cell membrane fluorescence.1978310740
characterization of lipopolysaccharide of haemophilus influenzae.lipopolysaccharide from strains of haemophilus influenzae was extracted and isolated by the hot phenol-water procedure. the preparations were relatively insoluble in water but could be solubilized with surface-active agents. the preparations contained carbohydrate (30%), fatty acid (29%), and phosphate (4.7%); protein content was less than 1%. thin-layer chromatography, gas-liquid chromatography, and colorimetric assays detected glucose, galactose, glucosamine, heptose, and a 2-keto-3-deoxy-octo ...1978310855
haemophilus influenzae as a cause of brodie's abscess in an infant.brodie's abscess is a form of subacute osteomyelitis which is defined by a particular constellation of clinical, radiological and pathological features. its occurrence in infants is extremely rare. this case documents just such an occurrence. to our knowledge, the pathogen haemophilus influenzae has not been previously recognized as a cause of brodie's abscess in particular or subacute osteomyelitis in general. the clinical presentation and diagnostic pitfalls which may be encountered in this ag ...1979310910
haemophilus influenzae infections in adults: report of nine cases and a review of the literature.haemophilus influenzae is an aerobic pleomorphic gram-negative coccobacillus that requires both x and v factors for growth. it grows poorly, if at all, on ordinary blood agar unless streaked with staph. aureus. it grows well on chocolate agar. because this medium is often not used in culturing specimens from adults and because the organism may be overgrown by other bacteria, the frequency of h. influenzae infections has undoubtedly been seriously underestimated. this is aggravated by the failure ...1979310943
cefamandole and cefoxitin. 1979310945
utility scaling of intracranial reinforcement duration. 1978311015
human mucosal lymphocytes - memory for 'recall' antigens and non-specific suppression by t-lymphocytes. 1978311142
[the influence of cryoprotective solutions on the ultrastructure of rabbit corneal endothelium (author's transl)].a series of rabbit corneae was preserved at -196 degrees c in liquid nitrogen using five different cryoprotective solutions: (1) 5% dextran t 40, (2) 10% polyvinylpyrrolidone, (3) 5% dextran t 40 + 10% polyvinylpyrrolidone + dimethyl sulfoxide, (4) 25% rabbit albumin + 10% polyvinylpyrrolidone, (5) 25% rabbit albumin + dimethyl sulfoxide. after thawing the corneae, the influence of the different cryoprotective solutions on the ultrastructure of corneal endothelium was evaluated and compared with ...1978311165
chloramphenicol and phenobarbitone--a drug interaction.two infants with meningitis who were treated with phenobarbitone and high-dose chloramphenicol showed progressive falls in the peak blood levels of chloramphenicol. a standard chloramphenicol dose of 50 mg/kg daily would have produced subtherapeutic blood levels after only a few days. the importance of measuring serial blood chloramphenicol concentrations is stressed.1979311186
comparison of vaccination of mice and rats with haemophilus influenzae and bordetella pertussis as models of atopy.1. rats and mice were vaccinated with haemophilus influenzae in different vaccination schedules whereafter blood eosinophils were counted. in rats a single vaccination resulted in a dose-dependent effect on the blood eosinophil count in a pattern comparable with that after bordetella pertussis vaccination. in a long-term vaccination schedule (five times a week for 5 weeks) rats developed a constant eosinophilia. in mice a single vaccination resulted in an eosinopenia of a consistent pattern whic ...1979311260
modification of dna in chromatin with methyltransferase from haemophilus influenzae rd.the accessibility of dna in nucleosome dimers (as a model of the chromosomal chain of nucleosomes) was determined by means of modification methylases from haemophilus influenzae rd. using these enzymes, the rate of modification of nucleosome dimers is about one fifth the rate observed with protein-free dna from chromatin subunit dimers. methylated dna sites in nucleosome dimers are readily accessible to micrococcal nuclease. the analysis of the fragment pattern of nucleosomes after methylation a ...1979311284
sequence-specific dna uptake in haemophilus transformation.haemophilus cells efficiently take up haemophilus dna from the medium during transformation but do not take up other dnas. to study the mechanism of this specificity we have cloned an 8.1-kilobase (kb) fragment of h. parainfluenzae dna in the escherichia coli--pbr322 host--vector system and reisolated the dna fragment for use as a defined probe. the 5'32p end-labeled 8.1-kb dna is efficiently absorbed by competent haemophilus cells whereas vector dna present in the mixture is not, implying that ...1979311478
possible postinfectious immune arthritis: haemophilus influenzae type b. 1979311582
haemophilus influenzae cellulitis in an adult.cellulitis due to haemophilus influenzae type b in adults has only recently been reported. we report a case in which the patient's antibody levels documented an immunologic response to the organism. the efficacy of a new cephalosporin antibiotic, cefoxitin sodium, in treating this infection also was established. cefoxitin has activity against ampicillin-resistant h influenzae and would be an alternative in treating h influenzae cellulitis.1979311624
thiamphenicol in treatment of haemophilus influenzae meningitis.17 infants and children with pyogenic meningitis (14 haemophilus influenzae, 2 diplococcus pneumoniae, 1 neisseria meningitidis) were treated with thiamphenicol, 100 mg/kg body weight/day in 4 doses i.v., as single drug. in the h. influenzae group 10 patients were cured, 4 had relapses of meningitis, 3 with documented subdural effusions. this group is compared with 14 children matched for age, initial leucocyte and csf cell count treated with ampicillin: all of these were cured, 1 had a subdural ...1977311771
recovery of haemophilus influenzae from twenty-three blood culture media.haemophilus influenzae is an important agent of bacteremia and has fastidious growth requirements. the purpose of this investigation was to determine the ability of commercial blood culture media to support the growth of this fastidious microorganism. twenty-three types of blood culture media were inoculated with individual suspensions of eight strains of h. influenzae in the presence or absence of an erythrocyte-serum mixture. the rates of recovery of the h. influenzae strains from the various ...1979311778
salient features of haemophilus vaginalis.a total of 78 strains of haemophilus vaginalis were examined for 104 features. all strains fermented dextrin, maltose, and starch. additionally, more than 90% of the strains fermented galactose, glucose, and ribose. arbutin, cellobiose, melibiose, rhamnose, and salicin were not fermented by any of these strains. none of the strains acidified any of 14 alcohols or alkalinized any of 25 organic salts and amides. more than 90% of the strains hemolyzed human blood agar and hydrolyzed hippurate. no s ...1979311779
haemophilus influenzae type d meningitis.this report describes an unusual pathogen associated with post-traumatic meningitis. haemophilus influenzae type d was isolated from both cerebrospinal fluid and blood of this patient with meningitis.1979311780
the infant rat as a model for assessment of the attenuation of human influenza viruses.the intranasal infection of infant rats with haemophilus influenzae type b can be considerably enhanced by prior infection of the rats with influenza virus. when influenza virus a/england/939/69 was used to infect the animals a minimum of 10(4-0) eid50 was required to enhance h. influenzae infection; infection with 4 x 10(6) h. influenzae bacteria was needed to reveal this enhancement and infant rats two days old at the time of virus inoculation had to be used. by this method, nine strains of in ...1979311833
chloramphenicol-resistant haemophilus influenzae. 1979311886
isolated congenital asplenia: an occult case of overwhelming sepsis. 1979312008
features of the damage produced by proflavine on transforming deoxyribonucleic acid.proflavine formed a complex with transforming deoxyribonucleic acid (dna) from haemophilus influenzae, with optimal formation at a ratio of proflavine to dna of 0.06. the rate of dissociation of the complex by dialysis increased in the order: native, denatured, renatured dna. the transforming activity of the dna was reduced by its interaction with proflavine. this inactivation was dependent on the physical state of the dna, the proflavine concentration, and the temperature. dna that had been den ...1979312284
hemophilus influenza septicemia and midtrimester abortion.a case of midtrimester septic abortion due to hemophilus influenza is discussed on the basis that the pathogeneses of the septic abortion was due to the hematogenous spread of the organism orginating from upper respiratory infection. the absence of ruptured membranes and the elevated antibody titer at the onset of the pelvic infection were in keeping with this hypothesis. additional data on the bacteriology of this organism and the probability of the occurrence of a type b organism with original ...1979312325
[acute bacterial arthritis in small children]. 1979312412
[bacterial flora in chronic maxillary sinusitis]. 1979312479
haemophilus influenzae type b disease in a day care center: eradication of carrier state by rifampin. 1979312483
treatment of haemophilus influenzae type b epiglottitis.during 1969-1977, 48 children with blood cultures proved positive for haemophilus influenzae type b epiglottitis were evaluated and treated. the fatality rate was 2%; one child died and another developed irreversible hypoxic brain damage. ninety-five percent of the children were intubated and none required tracheostomy. the endotracheal tubes remained in place for 3.3 +/- 1.5 days. short-term parenteral antimicrobial therapy, 4.0 +/- 1.4 days, was sufficient to eradicate bacteremia and prevent m ...1979312484
new concepts in otitis media.pneumatic otoscopy increases the physician's diagnostic acumen. movement of the tympanic membrane is observed and measured more precisely by tympanometry and acoustic impedance. ampicillin-resistant strains of hemophilus influenzae are appearing. it is possible to detect these with deep nasopharyngeal cultures. new reports show the value of antimicrobial prophylaxis in recurrent otitis media. high-risk populations that deserve special attention are children with cleft palate and down's syndrome.1979312593
endophthalmitis associated with haemophilus influenzae type b bacteremia and meningitis.the unusual occurrence of endophthalmitis associated with haemophilus influenzae type b bacteremia and meningitis was confirmed in three young children during a five-year period. in contrast to bacterial endophthalmitis attributed to other microorganisms, these three infections resolved completely within a few days with conventional antimicrobial therapy. endophthalmitis is but one of the apparently increasing number of unsuual complications that may be observed as a result of h influenzae type ...1979312601
lung abscess due to haemophilus influenzae type c. 1979312602
adenoids and otitis media with effusion.at adenoidectomy specimens for bacteriological, virological, and histological investigation were obtained from the adenoids of 144 children, 53 of whom suffered from otitis media with effusion, or frequently recurring otitis media. comparison of findings in children with ear diseases with those obtained in the rest of the material showed that hemophilus influenza was cultured from 50% of the specimens from the children with ear diseases, while only 14% of the cultures from the other children yie ...1979312617
acute bilateral suppurative parotitis due to haemophilus influenzae. report of two cases.acute bilateral suppurative parotitis developed in two patients with documented cirrhosis of the liver while they were in the hospital. gram's stain and culture of purulent material obtained from the orifice of stensen's duct disclosed haemophilus influenzae as the sole isolate. both patients were treated successfully with local care and antibiotics. to our knowledge, with one possible exception, infection of the parotid gland due to this organism has not been described previously.1979312630
a serological study of somatic antigens from haemophilus influenzae and two related species.somatic antigenic preparations from haemophilus influenzae strains, types a-f, and from non-capsulated h. influenzae strains obtained from the oral cavity of healthy individuals were analysed with the double-diffusion technique by means of antisera against the capsulated strains. the somatic precipitinogenic pattern of each of these strains, consisting of 12--20 lines, was very similar. in addition, the somatic antigenic pattern of one h. parainfluenzae strain and one strain tentatively designat ...1979312767
posttraumatic meningitis due to ampicillin-resistant hemophilus influenzae. case report.two men who sustained skull fractures secondary to blunt head trauma developed meningitis due to hemophilus influenzae type b. the isolates in both cases were resistant to ampicillin but susceptible to chloramphenicol. based of this experience, and recent epidemiological trends, it is suggested that chloramphenicol, rather than penicillin g, might be the initial therapy of choice for posttraumatic meningitis when no micro-organisms are recognized on gram-stained smears of the cerebrospinal fluid ...1979312922
effect of rifampin on nasopharyngeal carriage of haemophilus influenzae type b. 1979312927
diagnostic value of needle aspiration in haemophilus influenzae type b cellulitis. 1979312928
treatment of ampicillin-resistant haemophilus influenzae in soft tissue infections with high doses of ampicillin.six soft tissue infections (three epiglottitis, one cellulitis, one pneumonia, and one arthritis) with ampicillin-resistant haemophilus influenzae were treated initially with high doses of ampicillin (200 to 400 mg/kg/day intravenously) alone and had good clinical responses. all had documented bacteremia with h. influenzae. one child was treated only with ampicillin; treatment in the remainder was changed to oral therapy with other antibiotics to facilitate discharge. there was no recurrence of ...1979312930
pathogenesis of bacterial meningitis. studies on the route of meningeal invasion following hemophilus influenzae inoculation of infant rats. 1979312973
acute epiglottitis in an adult. 1979312999
haemophilus influenzae meningitis. a national study of secondary spread in household contacts.to determine the risk of severe haemophilus influenzae illness among household contacts of patients with h. influenzae meningitis, we studied prospective data obtained in 19 states from january 1, 1977, to june 30, 1978. h. influenzae meningitis was reported in 1403 patients, and 1147 (82 per cent) of the exposed families were investigated for the occurrence of h. influenzae disease within 30 days after its onset in the index patient. during this interval, nine of 1687 household contacts (0.5 pe ...1979313003
is haemophilus influenzae meningitis contagious? 1979313005
trauma-associated periorbital cellulitis due to haemophilus influenzae. 1979313039
biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human t cell lines.human malignant t cell lines have high levels of deoxyribonucleoside phosphorylating activity and low levels of deoxyribonucleotide dephosphorylating activity. when incubated with deoxyadenosine or thymidine, the malignant t cell lines rapidly accumulate toxic concentrations of datp and dttp, respectively. this unusual pattern of deoxyribonucleotide metabolism renders the malignant t cells especially vulnerable to the toxic effects of deoxyribonucleosides and related analogues.1979313056
revised spectra for the inactivation of haemophilus influenzae transforming dna by monochromatic ultraviolet light: effect of histidine. 1979313059
[effect of tobacco smoking and of air pollution on incidence of haemophilus influenzae in pharyngeal cavity (author's transl)]. 1979313061
hemophilus influenzae septicemia and polyarthritis in multiple myeloma.hemophilus influenzae sepsis, rare in adults, is reported for the first time in association with multiple myeloma. the patient developed fulminant septicemia involving multiple organs and disabling pyarthrosis due to nonencapsulated h influenzae, usually considered to be nonpathogenic. early diagnosis and appropriate antibiotic therapy cured the infection and prevented permanent joint disease. also illustrated is the problem of establishing a diagnosis of myclomatosis in patients with septicemia ...1979313078
the taxonomy and antimicrobial susceptibility of haemophilus species in clinical specimens. 1979313150
anaerobic and aerobic bacteriology of acute conjunctivitis.aerobic and anaerobic cultures and clinical data were obtained from 131 patients presenting with acute conjunctivitis. similar cultures were obtained from 60 noninflamed individuals. anaerobes were isolated from 66 patients, 51 times in mixed culture with aerobes and 15 times (11.5%) as the only isolates. aerobes only were recovered in 54 patients. the organisms found to be statistically significantly more commonly recovered from eyes with conjunctivitis were staphylococcus aureus, hemophilus in ...1979313179
on the nature of nontypable haemophilus influenzae.193 haemophilus cultures, including 71 nontypable h. influenzae isolates, were examined with respect to phage hp1 sensitivity, lysogeny for this and for other phages and for excretion of bacteriocins. fifty of the 71 nontypable cultures were sensitive to phage hp1 but only three produced plaques. the other 47 isolates were thus probably not non-encapsulated derivatives of h. influenzae serotypes a, b, d, and e, which have discrete and characteristic phage hp1 restriction and modification systems ...1978313183
bacteria in chronic maxillary sinusitis.sixty-one chronically inflamed maxillary sinuses produced 131 bacterial strains from mucosal pieces that were taken during a caldwell-luc operation and cultured aerobically and anaerobically. sinus secretions showed only 62 and nasal secretions 106 bacterial strains. fourteen mucosal strains, including 11 haemophilus influenzae, grew heavily. none of 24 mucosal anaerobes showed heavy growth. of 52 antral mucosae with culturable bacteria, 37 disclosed mixed and 15 pure growth. the bacteriological ...1979313206
pseudopodagra from hemophilus influenza in an adult. 1979313211
septic arthritis in childhood.in the first 4 years (1974 to 1978) of operation of the children's hospital of eastern ontario, in ottawa, 50 children were treated for septic arthritis. the neonatal group (birth to 6 months) of three patients had the most severe involvement and the worst prognosis. the early childhood group (6 months to 4 years) of 15 patients was characterized by sepsis due to hemophilus influenzae. the 32 older children (4 to 16 years), more susceptible to staphylococcal infections, commonly presented with a ...1979313236
plasmid transfer in haemophilus influenzae.twenty-nine strains of haemophilus influenzae highly resistant to ampicillin, chloramphenicol, or tetracycline were examined for the presence of plasmids. agarose gel electrophoresis of ethanol-precipitated cell extracts revealed large plasmids in 11 strains, of which 7 were conjugative. plasmid transfer by conjugation between isogenic strains was quite efficient, but transfer between different serotypes was nearly always much more inefficient. type i or ii restriction enzymes do not appear to b ...1979313393
biochemical characteristics of 130 recent isolates from haemophilus influenzae meningitis.a total of 130 haemophilus strains, comprising virtually all isolates from danish and norwegian cases of haemophilus meningitis occurring in the period from october 1975 through september 1976, were examined by biochemical and serological means. all isolates were identified as h. influenzae and, except for one noncapsulated strain, possessed a capsule of serotype b. the vast majority of strains (93%) belonged to biotype i, which, in contrast to biotypes ii and iii, is rarely encountered as a com ...1979313403
characterization of genes specifying ampicillin resistance in bacterial isolates using a single-strand specific nuclease for analysis of plasmid dna-dna duplexes. 1979313433
infectious parotitis in sjögren's syndrome: a case report and review of the literature.infectious parotitis as a complication of the sicca syndrome has rarely been reported. a patient with bilateral parotitis due to h. influenza in reported and the literature regarding this rare complication of the sicca syndrome is reviewed. the host defense mechanisms which ordinarily protect normal individuals or patients with sjögren's syndrome against purulent parotitis are discussed.1979313447
acute epiglottitis: 26 years' experience at the montreal children's hospital.two hundred and four cases of acute epiglottitis treated at the montreal children's hospital between 1951 and 1978 are reviewed. the comparison of tracheostomy vs. nasotracheal intubation is discussed. nasotracheal intubation has been found to be the treatment of choice as long as the necessary services are available in the hospital.1979313456
analysis of photoenzymatic repair of uv lesions in dna by single light flashes. xii. evidence for enhanced photolysis enzyme-substrate complexes by a 2-photon reaction.yeast photoreactivating enzyme (pre), preilluminated with wavelengths ranging from the near-uv to the red spectral region, forms with 254 nm-irradiated transforming dna of haemophilus influenzae enzyme-substrate complexes that are more efficiently photorepaired than complexes formed from non-preilluminated pre. the action spectrum for this "preillumination effect", previously shown to have a maximum in the near-uv region, has another maximum near 577 nm. in complexes formed from non-preilluminat ...1979313509
the vestibulo-ocular reflex in newborn rats.to study the development of vestibular functioning, the vestibulo-ocular reflex was tested in rats of increasing age. high frequency electrical stimulation of the vestibular nerve elicited characteristic conjugate eye movements in newborn rats well before the eyes were open (about day 15 after birth) and before the semi-circular canals had reached full adult size (about day 22 after birth). the threshold currents decreased during growth.1979313655
a mediator acting as a costimulator for the development of cytotoxic responses in vitro. 1979313677
acid alpha-naphthyl acetate esterase activity in human neoplastic lymphoid cells. usefulness as a t-cell marker.previous studies have shown that a distinctive pattern of acid alpha-naphthyl acetate esterase (anae) activity (focal reaction product) characterizes normal human peripheral blood and tissue t lymphocytes but is absent from thymocytes and certain mitogen-stimulated t-cell blasts. in the present study mononuclear cell suspensions prepared from the peripheral blood and tissue specimens of 35 patients with lymphoid malignancies were simultaneously analyzed for surface immunoglobulin, sheep erythroc ...1979313712
growth curves, microscopic morphology, and subcultures of beta-lactamase-positive and -negative haemophilus influenzae under the influence of ampicillin and cefamandole.in contrast to the results obtained with ampicillin, the minimum inhibitory concentrations of cefamandole against haemophilus influenzae were within the same range (0.5 to 1.5 mug/ml) whether or not the strains were beta-lactamase producers. the minimum bactericidal concentrations were somewhat higher for beta-lactamase-positive strains (6.4 mug/ml) than for negative strains (1.2 mug/ml). in a culture with high initial microbial density, monitored by recording optical densities, the addition of ...1979313751
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