| enhancement by sodium chloride of the selectivity of thiosulfate citrate bile salts sucrose agar for isolating vibrio cholerae biotype el tor. | in this study we utilized the salt-tolerant characteristics of vibrios to develop a more selective medium by addition of nacl to thiosulfate citrate bile salts sucrose (tcbs) agar. the effect of adding salt to tcbs agar varied greatly among brands of tcbs agar and between lots of the same brand. the addition of salt at concentrations as high as 1.5% (2.5% total nacl) caused the inhibition of growth of three species of commonly encountered normal bowel flora and one strain of classical vibrio cho ... | 1976 | 965476 |
| [epidemiological characteristics of cholera e1-tor]. | | 1976 | 968590 |
| [isolation and biological characterisitcs of l-forms of cholera vibrios]. | | 1976 | 969878 |
| effects of cholera toxin on cellular and paracellular sodium fluxes in rabbit ileum. | the diarrhea observed in patients with cholera is known to be related to secretion of water and electrolytes into the intestinal lumen. however, the exact mechanisms involved in these secretory processes have remained unclear. although it is clear that purified toxin acts on epithelial cell metabolism, its activity on na+ transport across intestinal mucosa is equivocal: reported either to prevent net na+ absorption or to cause net secretion of na+ from serosa to mucosa. since total transmural na ... | 1976 | 971435 |
| cell-mediated immunity to vibrio cholerae with ribonucleic acid-protein fractions of v. cholerae l-form lysates. | different l-form lysate vaccines of vibrio cholerae serotypes ogawa and inaba and their combination along with ethyl alcohol-precipitated ribonucleic acid (e-rna) and phenol-extracted rna (p-rna) fractions of v. cholerae ogawa lysates were tested for production of cell-mediated immunity. both e-rna and p-rna fractions induced an increase in leukocyte migration inhibition, macrophage migration inhibition, and macrophage aggregation. they also induced delayed hypersensitivity in rabbits. more cons ... | 1976 | 971951 |
| vibrio cholerae adherence and colonization in experimental cholera: electron microscopic studies. | colonization of the intestinal epithelium by vibrio cholerae was examined in two model systems, in ligated ileal loops of adult rabbits and in the patent gut of infant rabbits, using both scanning and transmission electron microscopy. time studies in the adult model showed a lag period of up to 1 h before the attachment of significant numbers of the vibrios. the bacteria appeared initially in small patches on the sides of the villi, predominantly along the transverse furrows. the number of adher ... | 1976 | 971962 |
| primary structure of the b subunit of cholera enterotoxin. | | 1976 | 976480 |
| bacteriological studies of cholera in visakhapatnam region of andhra pradesh. | | 1976 | 977064 |
| colonization of ascaris lumbricoides by v. cholerae. | | 1976 | 978375 |
| immunotherapy and chemotherapy in children with neuroblastoma. | recent advances with immunotherapy in animal tumors suggested that trials with a combination of chemotherapy and immunotherapy in human malignant tumors might be worthwhile. a pilot program with vibrio cholera neuraminidase-treated tumor cells plus bcg was tested in 3 patients who had had chemotherapy for disseminated neuroblastoma. two of these children were in "complete remission" after radiation therapy and chemotherapy before the administration of immunotherapy. relapse occurred in 5-6 month ... | 1976 | 978774 |
| [non-agglutinable vibrios (nag-vibrios) and cholera (author's transl)]. | | 1976 | 979518 |
| [neuraminidase as a pathogenicity factor in microbial infections (proceedings)]. | | 1976 | 983495 |
| the cholera enterotoxin--robert koch revisited [proceedings]. | | 1976 | 983499 |
| activation by cholera toxin of adenylate cyclase solubilized from rat liver. | cholera toxin, or peptide a1 from the toxin, activates adenylate cyclase solubilized from rat liver with lubrol px, provided that cell sap, nad+, atp and thiol-group-containing compounds are present. the activation is abolished by antisera to whole toxin, but not to subunit b. | 1976 | 985419 |
| adhesive properties of vibrio cholerae: adhesion to isolated rabbit brush border membranes and hemagglutinating activity. | adhesion of vibrios to the small intestine may occur (i) by association of the bacteria with secreted mucus gel or (ii) by adherence of the bacteria to the surface of epithelial cells. in the present study, vibrios readily adhered to isolated brush border membranes obtained from rabbit intestinal epithelial cells. adhesion was temperature dependent and required the presence of divalent cations such as calcium. the agglutination of human o erythrocytes by vibrio cholerae was observed also, and th ... | 1976 | 985804 |
| adhesive properties of vibrio cholerae: nature of the interaction with isolated rabbit brush border membranes and human erythrocytes. | nonmotile vibrio mutants lacked the ability to adhere to rabbit intestinal brush border membranes and to agglutinate human group o erythrocytes, but motile revertant vibrios isolated from such strains expressed adhesiveness equivalent to that of the original parent. two possible explanations for the relation between vibrio motility and adhesion in these assays systems are (i) that the rate of adhesion depends on the rate of chance contact brought about by motility, and (ii) that the flagellum ei ... | 1976 | 985805 |
| biochemistry of vibrio cholerae virulence: purification of cholera enterotoxin by preparative disc electrophoresis. | procedures for cholera enterotoxin purification previously developed in this labarotory were not applicable to large-scale purification, and these methods resulted in low yields of pure toxin. an efficient scheme has been developed whereby pure cholera enterotoxin can be obtained from 6 to 8 liters of culture supernatant fluid. this method consists of concentration by membrane ultrafiltration followed by gel filtration and cation-exchange chromatography. pure cholera enterotoxin of high biologic ... | 1976 | 987751 |
| practical estimation of the actual laboratory diagnostics of cholera. | | 1976 | 990543 |
| active and passive immunity to cholera toxin. | | 1976 | 992728 |
| determination of molecular weight of vibrio cholerae genome dna from renaturation rate. | | 1976 | 992812 |
| experimental development of antibiotic resistance in vibrio cholerae. | | 1976 | 992839 |
| immunological control mechanism against cholera toxin: interference with toxin binding to intestinal receptors. | the immunological control mechanism against cholera toxin (ct) in the small intestine of rats was studied in vivo. ct binding to intestinal receptors was determined by injected radiolabeled ct into the loops of rat small intestine and subsequently separating purified microvillus membranes from mucosal scrapings of those loops. substantial radioactivity (10(5) cpm/mg of microvillus protein) was present in microvillus fractions of small intestine exposed to 125i-labeled ct compared to radioactivit ... | 1976 | 992868 |
| an investigation of alternatives to hog gastric mucin as virulence-enhancing agents in the cholera vaccine potency assay. | | 1976 | 993220 |
| preventing insect diapause with hormones and cholera toxin. | | 1976 | 994697 |
| [sensitivity to antibiotics of el tor cholera vibrions]. | | 1976 | 999265 |
| the immunologic control mechanism against cholera toxin. ii. stimulation of adenylate cyclase without fluid secretion. | | 1976 | 999681 |
| cholera toxin and adenylate cyclase: properties of the activated enzyme in liver plasma membranes. | adenylate cyclase (ec 4.6.1.1) activity in mouse liver plasma membranes is increased fivefold when animals are pretreated with cholera toxin. the increase in activity is detectable within 20 min of an intravenous injection of the toxin. the response of the control and cholera-toxin-activated adenylate cyclase to hormones, gtp, and naf is complex. gtp causes the same fold stimulation of control and toxin-activated cyclase, but glucagon and naf remain the most potent activators of liver adenylate ... | 1976 | 1000362 |
| [case of contamination of the karst underground mineral-water stratum with vibrio cholerae]. | | 1976 | 1001931 |
| studies of the ligand binding to cholera toxin, i. the lipophilic moiety of sialoglycolipids. | the fixation of cholera toxin by ganglioside ggtet1 is dependent on the nature of the carbohydrate as well as the lipid moiety of the glycolipid. the role of the lipid in binding to the toxin investigated with synthetic ganglioside analogues (gangliosidoides). the interaction between glycolipid and toxin was followed by precipitate formation, by inhibition of toxicity and in polyacrylamide gel electrophoresis. for specific precipitation, an aliphatic hydrocarbon chain at least 14 c-atoms in leng ... | 1976 | 1002130 |
| lipolytic action of cholera toxin on fat cells. re-examination of the concept implicating gm1 ganglioside as the native membrane receptor. | the possible role of galactosyl-n-acetylgalactosaminyl-[n-acetylneuraminyl]-galactosylglucosylceramide (gm1) ganglioside in the lipolytic activity of cholera toxin on isolated fat cells has been examined. analyses of the ganglioside content and composition of intact fat cells, their membranous ghosts, and the total particulate fraction of these cells indicate that n-acetylneuraminylgalactosylglucosylceramide (gm3) represents the major ganglioside, with substantial amounts of n-acetylgalactosamin ... | 1976 | 1002701 |
| [the protective and immunodepressive activity of cell fractions of a cholera-like vibrio]. | a study was made of the protective and immunodepressive activity of the sytoplasmic fractions of a cholera-like vibrio. ribosomal fraction proved to possess more marked protective and immunodepressive properties than the soluble cytoplasmic fraction. | 1976 | 1007718 |
| [a study of immunological efficacy of the oral chemical cholera vaccine on experimental animals]. | three fractions isolated from the culture fluid of the 569b cholera vibrio strain were studied. the fractions differed by the extent of purification, and the content of the toxid and the o-antigen. in intraintestinal application to rabbits all of them caused formation of antitoxins and vibriocidal antibodies in the blood serum. the immunizing dose of the preparations in intraintestinal administration exceeded the dose required for subcutaneous application. fraction i should be used for producing ... | 1976 | 1007720 |
| [a comparative study of ultrastructural organization of the nonagglutinating vibrios and the causative agents of cholera]. | a common plan of ultrastructural organization was revealed in a comparative study of the ultrastructure of the nonagglutinating el tor and cholera vibrios: the presence of a three-layer cell wall and cytoplasmic membrane, the presence of vesicles on the external layer of the cell wall or between the cell wall and the cytoplasmic membrane; identity of the intracytoplasmic membranous structures; the presence of intracytoplasmic inclusions in the form of granules of various size and electron densit ... | 1976 | 1007727 |
| [experimentally induced cholera in guinea pigs. i. elaboration of the method of infection]. | the method of intrapulmonary infection of guinea pigs was suggested for the assessment of the virulent properties of cholera vibrios. addition into the diluent of 10% peptone, 10% gelatine and 0.05% agar-agar led to the reduction of ld50 by over 1000 times. a specific infectious process coursing in an acute generalized form with bacteriemia and affection of the small intestine developed in the infected animals. the majority of the animals perished in 1 to 2 days. | 1976 | 1007732 |
| sequence of events in the activation of adenylate cyclase by cholera toxin. | the toxin of vibrio cholera causes fluid secretion from the small intestine by stimulation of adenylate cyclase and elevation of intracellular cyclic amp concentrations. the toxin is a protein composed of subunits responsible for binding to cell membranes and a subunit responsible for the activation of adenylate cyclase. the binding subunits (b) are non-covalently bonded to the active subunit (a). the latter is composed of two polypeptides a1 and a2 linked by a disulphide bridge. exposure of the ... | 1976 | 1009263 |
| spectrophotometric studies of base composition & helix-coil transition of vibrio cholerae dna. | | 1976 | 1010578 |
| effects of noxious stimulation of the skin on transmission through the spinocervical tract [proceedings]. | | 1976 | 1011101 |
| study of genetic relationships among marine species of the genera beneckea and photobacterium by means of in vitro dna/dna hybridization. | strains representative of species of the marine genera beneckea and photobacterium were used as reference standards in in vitro dna/dna competition experiments. within a given species, strains were found to be related by over 80% competition. (competition was defined as the amount of radioactive dna displaced by heterologous dna relative to the amount displaced by homologous dna.) on the basis of interspecies competition values (expressed as averages), the following groupings could be made: 1. " ... | 1976 | 1015934 |
| [inhibiting effect of cholera vibrio neuraminidase in rauscher mouse leukemia]. | a study was made of the inhibitory effect of neuraminidase of cholera vibrio in mouse rauscher leukemia. it was shown that the processing of cells of the spleen of mice suffering from leukemia with neuraminidase (in a dose of 50 units/ml and more) significantly inhibited the capacity of these cells to induce leukemia in their injection to balb/c mice. in the mentioned concentration neuraminidase injected repeatedly parenterally produced no therapeutic effect in rauscher leukemia. | 1976 | 1016719 |
| antibiotic sensitivity pattern of v. cholerae strains isolated in 1974. | | 1976 | 1017856 |
| [small outbreak of cholera in the province of orense]. | | 1976 | 1019557 |
| adjuvant immunochemotherapy of murine neoplasms. | | 1976 | 1019835 |
| synergistic lymphocyte stimulation to tumor--specific antigens after immunization with modified tumor cells. | | 1976 | 1019838 |
| serological response and serum immunoglobulin levels in volunteers immunized with cholera toxin. | | 1976 | 1022695 |
| [role of local factors of immunity with regard to cholera infection. i. localization and multiplication of vibrios in ligated small intestine loops of non-immunized rabbits and newborn animals]. | | 1976 | 1023438 |
| [improvement in the method of obtaining monospecific sera to soluble antigens]. | | 1976 | 1023445 |
| sensitivity of vibrio group of organisms to minocycline--a new tetracycline derivative. | | 1976 | 1024085 |
| [long-term survival of e1 tor cholera vibrios in naturally contaminated sewage]. | el tor cholera vibrios of ogava serological type were revealed in the sewage of the locomotive shed for 15 months. in experiment with an oil catcher in naturally infected sewage el tor vibrios survived 36 days, in storage of this sewage at the laboratory--39 days, in the artificially infected sewage of a settlement and of a milk plant--2 and 11 days, respectively, in the oil and disel fuel--14 months. consequently, el tor vibrio can survive in the sewage with a high oil product content for a lon ... | 1976 | 1024446 |
| [phage typing of cholera vibrios with different sets of phages]. | a comparative study was made of two sets of mukerjee and drozhevkina-arutyunova's bacteriophages in typing 514 strains of the el tor vibrios and 45 strains of clasic biotype. it was shown that the mukerjee or drozhevkina-arutyunova's phages could be used for the typing of cholera vibrios. the phages of the latter set prove to detect more phage types (18 against 11); they determine both the phage type and the biotype at the same time. the typing of cholera vibrios of both biotypes is possible, an ... | 1976 | 1024447 |
| [reactogenicity and immunologic effectiveness of cholerogen-anatoxin. feasibility of revaccination with cholerogen-anatoxin, determination of optimal doses and times for administration]. | the authors discussed the results of study of the titre of vibration antibodies and antitoxins one, three and five months after the vaccination of adults with an optimal vaccination dose of cholerogen toxoid (24oo bu). comparison of the immunological information obtained at the above mentioned periods showed the expediency of revaccination three months after the vaccination. immunogenicity of the three doses of the cholerogen-toxoid tested (1200, 2400, 3600 bu) displayed no statistically signifi ... | 1976 | 1024451 |
| positional distribution of fatty acids in phosphatidylethanolamine of vibrio cholerae 569 b (inaba) at different growth conditions. | | 1976 | 1024965 |
| comparative studies on the enzymes of different strains of vibrio cholerae & vibrio parahaemolyticus. | | 1976 | 1024973 |
| inhibition of adp-induced platelet aggregation as a possible test for evaluation of the enterotoxigenicity of some enterobacteria. preliminary study]. | some culture filtrates or enterotoxin preparations from enterobacteria that activate the adenylate cyclase system (vibrio cholerae, lt fraction from escherichia coli and klebsiella pneumoniae, shigella dysenteriae type 1) exibit an inhibiting effect on adp-induced platelet aggregation, while other enterotoxin preparations not effective on adenylate cyclase system, don't interfere with this model. the a. propose the platelet aggregation as cellular assay to detect enterotoxin fractions effective ... | 1976 | 1028645 |
| humoral reponse to neuraminidase-treated tumor cells. | l1210 leukemia cells grew progressively and caused tumor deaths in all recipient mice. however, when these cells had been treated with vibrio cholerae neuraminidase (vcn) prior to injection, tumor deaths did not occur. both untreated and vcn-treated l1210 cells elicited a humoral response, as manifested by an increasing percent of cells in the spleen and peritoneal cavity, with various types of membrane-associated immunoglobulins. progressive tumor growth was associated with a large percent of p ... | 1976 | 1032896 |
| [clinical and therapeutic study of cholera in dahomey. (133 clinical cases)]. | | 1976 | 1036472 |
| [behavior of vibrio cholerae strains of the biotype el tor isolated in apulia in 1973, in relation to various antibiotics and chemotherapeutics]. | the tests carried out on the strains of vibrio cholerae of the el tor biotype, isolated during the epidemic in apulia in 1973, brought to light the sensitivity of all the strains to various antibiotics and chemotherapeutic substances. only one initially sensitive strain, when it was isolated again in the same patient, proved to be resistant to tetracycline. on the basis of this discovery and others communicated in published works, the authors outline the problems posed by the emergence of antibi ... | 1975 | 1047628 |
| ligand-induced redistribution of lymphocyte membrane ganglioside gm1. | dynamic aspects of the binding of cholera toxin to lymphocyte membranes have been studied. we have shown that the receptor for this ligand--the gm1 ganglioside--can be laterally redistributed into aggregates and caps. exogenous purified gm1 inserted into gm1-deficient human leukaemic cells can undergo a similar pattern of ligand-induced mobilisation. these observations may have important implications for both the general behaviour of cell surface glycolipids and the mode of action of cholera tox ... | 1975 | 1057731 |
| interaction of cholera toxin and membrane gm1 ganglioside of small intestine. | ganglioside gm1 was isolated from the small intestinal mucosa of man, pig, and beef and amounted to 0.1, 2.0, and 43 nmol per g fresh weight, respectively. these differences in gm1 content were associated with a quantitatively differing ability of the mucosal cells to bind cholera toxin. human cells bound about 15,000 toxin molecules when saturated with the toxin, porcine cells 120,000, and bovine cells 2,600,000 molecules. the association constant (ka) of the cholera toxin binding was, for cell ... | 1975 | 1058471 |
| stimulation of epinephrine-sensitive fat cell adenylate cyclase by cytosol: effect of cholera toxin. | cytosol prepared from rat epididymal fat cells by centrifugation at 100,000 x g for 1 hr was found to enhance the basal and epinephrine-sensitive adenylate cyclase [ec 4.6.1.1; atp pyrophosphate-lyase (cyclizing)] of fat cell ghosts. cholera toxin also stimulated adenylate cyclase and increased the response to epinephrine in fat cells. a possible relationship between the adenylate cyclase modifying activities of cytosol and the effects of cholera toxin was sought. cytosol from freshly prepared f ... | 1975 | 1059143 |
| type-specific action of vibriocidal antibody on vibrio cholerae. | the vibriocidal activity of inaba and ogawa antisera, from which cross-reacting agglutinin had been absorbed, was specific for vibrio cholerae strains of the homologous serotype. no vibriocidal action against strains of the heterologous type was detected. the sera appeared to be equally effective in killing organisms of different biotypes (classical, intermediate, and eitor), provided that these were of the homologous serotype (inaba or ogawa). however, they had been raised against strains of th ... | 1975 | 1059707 |
| mobility of cholera toxin receptors on rat lymphocyte membranes. | fluorescein-labeled cholera toxin binds detectably to 40-60% of rat mesenteric lymph node cells and induces a temperature-dependent redistribution (patch and cap formation) of cell surface toxin receptors. the redistribution is inhibited by several "metabolic," "microtubule," and "microfilament" inhibitors, by concanavalin a, and by anticholera toxin igg. various studies indicate that cholera toxin is at least bivalent, and that this property may be related to both the induction of receptor redi ... | 1975 | 1060063 |
| immunological studies in murine osteosarcoma. immunogenicity, growth kinetics, and immunotherapy. | a transplantable murine osteosarcoma is described. following transplantation into a syngeneic mouse the tumor grows rapidly and kills the mouse with pulmonary metastases simulating human osteosarcoma. a cell-mediated antibody response is evoked in the host mouse as demonstrated by in vivo and in vitro tests. the number of pulmonary metastases may be decreased with adjunctive immunotherapy following excision of the primary tumor. immunotherapeutic materials include bcg and isologous cells treated ... | 1976 | 1063129 |
| immunotherapy of human leukemia with neuraminidase-modified cells. | | 1976 | 1063908 |
| comparative study of alkaline phosphatase activity in lymphocytes, mitogen-induced blasts, lymphoblastoid cell lines, acute myeloid leukemia, and chronic lymphatic leukemia cells. | alkaline phosphatase [orthophosphoricmonoester phosphohydrolase (alkaline ph optimum), ec 3.1.3.1] purified from a burkitt lymphoma cell line (daudi) and moloney-virus-induced murine leukemia (yac) showed unique catalytic properties in substrate specificity and inhibition by cysteamine-s-phosphate. it migrated on polyacrylamide gel electrophoresis in a single activity band. alkaline phosphatase with similar properties was found in several human lymphoblastoid cell lines, in chronic lymphatic leu ... | 1976 | 1064015 |
| elucidation of hydrocarbon structure in an enzyme-catalyzed benzo[a]pyrene-poly (g) covalent complex. | the carcinogen, benzo[a]pyrene, was covalently attached to poly (g) by liver microsomes from rats pretreated with 3-methylcholanthrene. the complex was hydrolyzed with enzymes or base and products were isolated by sephadex chromatography. absorbance and fluorescence spectra of the products fit that of red-shifted pyrene aromatic system and suggest that metabolism has occurred at the 7-, 8-, 9-, and 10-positions of the hydrocarbon. benzanthracene or chrysene fluorescence were not observed in thes ... | 1976 | 1064016 |
| immune markers in adult acute leukemia. | three cases of adult acute leukemia were examined for immunologic markers. incubation of leukemic cells with anti-d (igg)-coated erythrocytes was used for the identification of monocytes; sheep erythrocytes were employed for t-cells and fluorescein-conjugated anti-mixed immunoglobulins for b-cells. it was shown that igg receptors (monocytes) were present on immature cells with predominant monocytic components; t- and b-cell markers were absent in the mono- and myelocytic leukemias. | 1976 | 1065217 |
| inhibition of calcium phosphate precipitation by human salivary secretions. | | 1976 | 1065265 |
| [induction of phagocytosis by immunotherapy against leukemic leukocytoblasts]. | since 1975, the authors have been working in immunochemotherapy in acute myeloblastic leukemic adult patients. autologous leukemic leucocytoblasts have been cultured with vibrio cholerae neuraminidase (nvc). thereafter, neoplastic cells were radiated with cobalt bomb and frozen to--70degreesc and afterwards 5 x 10(6) of these leucoblasts were intradermally injected to each patients every eight days. all patients received between six to ten injections. so far, ten such patients have been followed ... | 1976 | 1066088 |
| immune responses in cholera vaccinated persons. | | 1976 | 1066435 |
| choleragen-mediated release of trapped glucose from liposomes containing ganglioside gm1. | 125i-labeled choleragen was bound to liposomes containing galactosyl-n-acetylgalactosaminyl-(n-acetylneuraminyl)-galactosylglucosylceramide (gm1), but not in large amounts to ganglioside-free liposomes nor to those containing n-acetylneuraminylgalactosylglucosylceramide (gm3), n-acetylgalactosaminyl-(n-acetylneuraminyl)-galactosylglucosylceramide (gm2), or n-acetylneuraminylgalactosyl-n-acetylgalactosaminyl-(n-acetylneuraminyl)-galactosylglucosylceramide (gd1a). choleragen released trapped gluco ... | 1976 | 1068459 |
| therapeutic effectiveness of neuraminidase-treated tumor cells as an immunogen in man and experimental animals with leukemia. | the immunogenicity of leukemia l1210 in dba/2 ha and 6c3hed lymphosarcoma tumor cells in c3h/f mice was significantly increased after treatment with v. cholerae neuraminidase. dba/2 ha and c3h/f mice repeatedly immunized with neuraminidase-treated tumor cells rejected subsequent challenge of 10(7) or 10(6) untreated tumor cells, respectively. based on the 51cr microcytotoxicity assay, both strains of mice showed strong complement-dependent antibody titers and cell-mediated immunity. sera and spl ... | 1976 | 1069551 |
| adjuvant immuno- and/or chemotherapy with neuraminidase-treated autogenous tumor vaccine and bacillus calmette-guérin for head and neck cancers. | | 1976 | 1069553 |
| inter-relationship between autoregulation of glomerular filtration rate, tubuloglomerular feedback and juxtaglomerular renin activity in normotensive and hypertensive rats. | 1. reduction of renal perfusion pressure from 133 mmhg to 117 mmhg in control rats did not induce a significant change of kidney glomerular filtration rate (gfr) or nephron gfr determined in distal tubules. in contrast, nephron gfr measured in proximal tubular segments (ngfr-p) fell significantly. 2. qualitatively the same response of filtration rate to changes of arterial blood pressure was found in the chronically clipped kidneys of goldblatt hypertensive rats after acute removal of the clip. ... | 1976 | 1071583 |
| [the nature of nuclear enlargement in urethane and isoprotenol-stimulated salivary glands (author's transl)]. | | 1975 | 1073694 |
| sialic acids and sialyltransferases in murine lymphoid cells: indicators of t cell maturation. | | 1975 | 1079171 |
| mechanism of action of cholera toxin. specific inhibition of toxin-induced activation of adenylate cyclase. | | 1975 | 1079778 |
| six and one-half month old infant with fever and irritability. | | 1975 | 1081274 |
| [determination of choleragen activity in tadpoles]. | a method of titration of the v. cholerae toxin obtained from the broth culture filtrates is presented. in difference from the earlier methods, the larvae of rana temporaria were used as a test object. the tadpoles were placed in the vessels with water containing graded concentrations of the toxin. the titer of the toxin activity was evaluated by the percentage of dead tadpoles. the concentration causing the death of 50 per cent of the tadpoles in the course of the 24 hours was taken as a unit of ... | 1975 | 1082777 |
| ampicillin-resistant hemophilus sp. | | 1976 | 1082793 |
| [influence of substances that change the serotonin level of the brain on the analgesic effect of promedol in rats]. | in tests with determination of pain reaction in rats registered by their squeak and arising in reponse to a single electric irritation of the tail evidence was obtained to the effect that substances both lowering the serotonin content in the brain (p-chlorphenylalanine, reserpine) and raising it (5-oxytryptophan, pargilin) cause a fall of the threshold, viz. 5-oxytryptophan and pargilin display antagonism to the analgetic effect of trimeperidine hydrochloride, whereas p-chlorphenylalanine, and i ... | 1976 | 1082823 |
| epithelial regeneration of transposed intestine after high doses of x-irradiation. | the regeneration capacities of normal and transposed small bowel epithelium were compared in rats after applying high doses of x-irradiation. it has been shown that the potency of the mucosa to regenerate is much higher than assumed and that the mucosa can regenerate after single doses varying from 2000-5000 r. even in the villus epithelium and in flat epithelium covering infiltrates of the lamina propria cells survive, which are still able to resume proliferative activity several days after irr ... | 1976 | 1083838 |
| [research on v. cholerae anti-antibodies (agglutinating and vibriocidal) in patients affected by cholera-like gastroenteritis. studies performed during the cholera epidemic occurred in apulia in august-september 1973]. | agglutinating and vibriocidal antibody titers anti-v. cholerae of the serotypes ogawa and inaba, were determined in sera from 189 patients with cholera-like diarrheas during the epidemic of cholera occurred in august-september 1973, in bari. antibodies were determined in 74,2% of 70 patients, whose in the faeces and vomiting were isolated strains identified as v. cholerae, biotype el tor, serotype ogawa. this frequency was higher against the serotype ogawa. the antibodies could be proved very ea ... | 1975 | 1084731 |
| photobiological activity of furazolidone. | | 1976 | 1086295 |
| a streptomycin-sensitive revertant of a streptomycin-dependent strain of vibrio cholerae. | a study was made of a streptomycin-sensitive revertant of a streptomycin-dependent strain of v. cholerae. the revertant, designated as strain kb599, appears to be avirulent in animal experimental models. however, no evidence of multiplication was found in infant mice. | 1976 | 1086742 |
| intestinal immunization with soluble bacterial antigens: the example of cholera toxoid. | the studies described are aimed at a better understanding of the intestinal immunological system and its role in protection against enteric infection. the cellular kinetics of the intestinal immune response to cholera toxoid were studied in rats and the protection afforded by toxoid immunization was studied in dogs. memory was demonstrated in the gut immune system. plasma cells containing iga antitoxin appeared in large numbers in gut lamina propria when intraduodenal boosting followed either in ... | 1976 | 1086763 |
| membrane expression of thy-1,2 and gm1 ganglioside on differentiating t lymphocytes. | c3h mouse bone marrow cells were separated by discontinuous bsa gradient centrifugation. marrow cells from the 17 to 19%, 19 to 21% to 23%, 23 to 25%, 25 to 27% interfaces and the cell pellet were treated with thymic factor (tf) or with vibrio cholerae neuraminidase (vcn), followed by anti-thy-1,2 and anti-gm1 ganglioside antisera. antigens determined by anti-thy-1.2 or anti-gm1 were expressed either with tf or vcn within a 30-min incubation. cells expressing these antigens after vcn or tf treat ... | 1976 | 1086862 |
| surface molecules of cultured human lymphoid cells. | cell surface molecules of cultured human lymphoid cells were selectively labeled by lactoperoxidase-catalyzed iodination and examined by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. two major iodinated species with apparent mol. wts. of 27 000 and 35 000 daltons were detected on autoradiographs of the labeled proteins of human lymphoid cell lines believed to be of thymus-independent (b) cell origin. neither molecule was detected on putative thymus-dependent (t) l ... | 1976 | 1087235 |
| nucleosides. 1. 9-(3'-alkyl-3'-deoxy-beta-d-ribofuranosyl)adenines as lipophilic analogues of cordycepin. synthesis and preliminary biological studies. | a series of lipophilic 9-(3'-alkyl-3'-deoxy-beta-d-ribofuranosyl)adenines of increasing chain length was synthesized from the corresponding branched sugars via titanium chloride catalyzed ribosylation of chloromercuri-6-benzamidopurine. enhanced growth inhibitory activity was observed against (ccrf-cem human lymphoblastic leukemia cells in culture as the length of the alkyl side chain in the sugar and the resultant lipophilic character of the nucleoside were increased. experiments involving inco ... | 1976 | 1087343 |
| persistence of anti-immunoglobulin on the lymphocyte surface. | | 1976 | 1087371 |
| ampicillin-resistant strains of haemophilus influenzae type b in north carolina. | | 1976 | 1087376 |
| [long-term cardiac arrest by cardioplegic coronary perfusion (author's transl)]. | the mg++ aspartate-procaine-cardioplegia has been proven in animal experiments as well as from 1970 til 1975 in more than 1000 open-heart-procedures by a myocardial temperature of 32 degrees c and aortic crossclamping time up to 40 minutes superior to all other known procedures of cardiac preservations. to guarantee a safe myocardial protection of the arrested heart for a remarkable longer period of total ischemia, we further developed the cardioplegic technique in the animal lab, and use it now ... | 1976 | 1087482 |
| sensitivity of trichomonas vaginalis to metronidazole, tinidazole, and nifuratel in vitro. | prompted by the sensitivity of trichomonads to metronidazole and nifuratel in clinical practice, a study was conducted in 1971-1972 of 63 consecutive strains of trichomonas vaginalis isolated from women with clinically refractory vaginal discharge. their susceptibility to metronidazole, tinidazole, and nifuratel was tested, using a serial tube dilution technique. the minimum concentrations which in 48 hrs caused immobilization and lysis of trichomonads cultured in diamond's medium was assessed. ... | 1976 | 1087577 |
| yersinia enterocolitica : a review of its role in food hygiene. | since yersinia enterocolitica, now classified as a member of the enterobacteriaceae, was recognized as a distinct species in 1964 it has been isolated with increasing frequency from man and animals (including dogs and pigs) and from some human foods. y. enterocolitica infections are now seen as a cause for some concern in both human and veterinary medicine. the organism is commonly found in specimens from swine slaughterhouses and has been isolated from samples of market meat, vacuum-packed beef ... | 1976 | 1087589 |
| immunological studies on metastrongylus apri infection. iv. influence of whole body x-irradiation or anti-guinea pig thymocyte serum injection on acquired immunity in thymectomized guinea pigs. | | 1976 | 1087673 |
| treatment of pneumocystis carinii pneumonia in infancy. | pentamidine is recommended for the therapy of pneumocystis carinii pneumonia either alone or, in severe cases, combined with pyrimethamine. attention is drawn to the importance of supporting symptomatic treatment, particularly with the promethazine-hydergine cocktail, and to the possibilities for general and drug prophylaxis. | 1976 | 1087956 |
| effect of sulfadoxine on transmission of vibrio cholerae infection among family contacts of cholera patients in calcutta. | sulfadoxine, a long-acting sulfonamide, and tetracycline were compared as regards their effectiveness in reducing transmission of cholera infection among the contacts of cholera patients in calcutta. a total of 109 healthy family contacts of confirmed hospitalized cholera patients were treated with a single oral dose of sulfadoxine graded according to age. another similar group of 101 contacts received 6 divided doses of oral tetracycline over a period of 3 days. all these contacts were bacterio ... | 1976 | 1088098 |
| global surveillance of antibiotic sensitivity of vibrio cholerae. | strains of vibrio cholerae-1156 from various parts of the world-were examined by standardized antibiotic sensitivity tests in one centre, to determine the global incidence of antibiotic resistance in this organism and to assess the extent to which differences in methods of sensitivity testing might be responsible for discrepancies in the reported incidence of resistant strains. of the strains examined, 1127 were fully sensitive to ampicillin, chloramphenicol, tetracycline, furazolidone, and thre ... | 1976 | 1088100 |
| value of phage typing of vibrio cholerae biotype eltor in west africa. | the epidemiological value of phage typing of el tor vibrios in west africa was assessed by testing 211 representative strains from all outbreaks of the cholera epidemic in togo (1970-73) with the prophage typing method of nicolle et al. and the lytic el tor phages of basu & mukerjee. prophage typing proved to be of limited epidemiological value in togo since 203 of the 211 strains tested belonged to the same phage type-namely, type 2 of nicolle et al., which corresponds to the celebes type of ta ... | 1976 | 1088101 |
| [study of the heterogenetic antigens in vaccinal preparations of v. cholerae]. | there proved to be a serological similarity between the antigens of the human small intestine, the stomach and the liver, and the antigens of various cholera vibrio fractions. no antigenic similarity was revealed in examination of the heart and kidney. heterogenous antigen was found not only in the somatic v. cholerae antigen, strain 569 (b), but also in the cholerogen-toxoid obtained from it. at present it is the most widespread prophylactic preparation. | 1976 | 1088347 |
| [pathogenesis of toxin caused gastroenteritis of vibrios and coli bacteria]. | | 1975 | 1089519 |