| a complementary tool for management of disseminated histoplasma capsulatum var. capsulatum infections in aids patients. | in south america, disseminated histoplasmosis due to histoplasma capsulatum var. capsulatum (h. capsulatum), is a severe and frequent opportunistic infection in aids patients. in areas outside the usa where specific-histoplasma antigen detection is not available, the diagnosis is difficult. with the galactomannan antigen (gm) detection, a test commonly used for invasive aspergillosis diagnosis, there is a cross-reactivity with h. capsulatum that can be helpful for the diagnosis of histoplasmosis ... | 2014 | 25201327 |
| a case of orbital histoplasmosis. | histoplasma capsulatum var capsulatum is a dimorphic fungus endemic to the ohio and mississippi river valleys of the united states. in this case report, a 33-year-old woman who presented with a right orbital mass causing progressive vision loss, diplopia, and facial swelling is described. lateral orbitotomy with lateral orbital wall bone flap was performed for excisional biopsy of the lesion. the 1.5 × 1.8 × 2.3 cm cicatricial mass demonstrated a granulomatous lesion with necrosis and positive s ... | 2017 | 25186215 |
| hiv-associated histoplasmosis early mortality and incidence trends: from neglect to priority. | histoplasmosis is an endemic fungal infection in french guiana. it is the most common aids-defining illness and the leading cause of aids-related deaths. diagnosis is difficult, but in the past 2 decades, it has improved in this french overseas territory which offers an interesting model of amazonian pathogen ecology. the objectives of the present study were to describe the temporal trends of incidence and mortality indicators for hiv-associated histoplasmosis in french guiana. | 2014 | 25144374 |
| [american histoplasmosis: clinicopathological features in immunocompetent and immunocompromised patients. a report of two cases of infection by histoplasma capsulatum on reunion island]. | histoplasmosis is a fungal infection caused by histoplasma capsulatum var. capsulatum. it shows pulmonary or multivisceral involvement. infective spores are inhaled from soils that contain bat or bird guano. the clinical picture depends on the intensity of the exposure and the immune status of the host. | 2014 | 24878163 |
| in vitro inhibitory effect of miltefosine against strains of histoplasma capsulatum var. capsulatum and sporothrix spp. | miltefosine (mil), originally developed for use in cancer chemotherapy, has been shown to have important antifungal activity against several pathogenic fungi. our aim in this study was to determine the in vitro activity of mil against the dimorphic fungi histoplasma capsulatum and sporothrix spp. this was done using the broth microdilution method. mil had an in vitro inhibitory effect against all strains of h. capsulatum var. capsulatum and sporothrix spp. analyzed. the minimal inhibitory concen ... | 2014 | 24662247 |
| [aspergillus galactomannan assay for the management of histoplasmosis due to histoplasma capsulatum var. duboisii in hiv-infected patients: education from a clinical case]. | the diagnosis of histoplasmosis due to histoplasma capsulatum var capsulatum is based on a direct examination identifying encapsulated yeast with narrow-based budding. galactomannan antigenemia facilitates diagnosis, as well as the monitoring of patients receiving treatment. the case of a hiv-positive patient from congo-brazzaville with a disseminated form of african histoplasmosis highlighted the positive galactomannan antigen in this disease due to histoplasma capsulatum var duboisii. galactom ... | 2014 | 24636196 |
| synthesis and antifungal activity in vitro of isoniazid derivatives against histoplasma capsulatum var. capsulatum. | histoplasmosis is a severe infection that affects millions of patients worldwide and is endemic in the americas. amphotericin b (amb) and itraconazole are highly effective for the treatment of severe and milder forms of the disease, but amb is toxic, and the bioavailability of itraconazole is erratic. therefore, it is important to investigate new classes of drugs for histoplasmosis treatment. in this study, a series of nine isoniazid hydrazone derivatives were synthesized and evaluated for their ... | 2014 | 24514090 |
| [histoplasma capsulatum var. capsulatum darling]. | | 2013 | 23877779 |
| a case of histoplasma capsulatum endophthalmitis diagnosed in italy. | histoplasma capsulatum var. capsulatum is a dimorphic fungus endemic in the eastern united states and most countries of latin america. sporadic cases of histoplasmosis have been reported in europe, mainly in immigrants or people returning from highly endemic areas. we report a case of 64-year-old italian man with endophthalmitis, an unusual presentation of h. capsulatum infection. the patient shows redness, blurred vision, localized pain in the right eye. h. capsulatum was cultured from a vitreo ... | 2013 | 22999789 |
| evaluation of the genetic diversity of histoplasma capsulatum var. capsulatum isolates from north-eastern brazil. | since the beginning of the hiv epidemic, there has been a significant increase in the number of histoplasmosis cases in ceará, a state in north-east brazil. the lack of epidemiological data on the genotypes circulating in the north-east region shows the importance of more detailed studies on the molecular epidemiology of histoplasma capsulatum var. capsulatum in this region. different molecular techniques have been used to better characterize the genetic profile of h. capsulatum var. capsulatum ... | 2012 | 22977075 |
| disseminated cutaneous histoplasmosis in an immunocompetent adult. | histoplasmosis, a systemic mycosis caused by the dimorphic fungus histoplasma capsulatum var capsulatum and histoplasma capsulatum var duboisii is endemic to many parts of the world. the clinical manifestations range from acute or chronic pulmonary infection to a progressive disseminated disease. after initial exposure to the fungus, the infection is self-limited and restricted to the lungs in 99% of healthy individuals. the remaining 1%, however, progress to either disseminated or chronic disea ... | 2012 | 22707773 |
| seven imported histoplasmosis cases due to histoplasma capsulatum var. capsulatum: from few weeks to more than three decades asymptomatic period. | histoplasma capsulatum is a nonendemic fungus in europe. epidemiological, clinical biological features and follow-up of seven imported cases in france were reported. these cases underlined the difficulties of such diagnosis in nonendemic areas due to greatly variable asymptomatic period, and lack of specific clinical signs. thus, anamnesis should be carefully analysed; mucocutaneous signs and immunosuppression should be systematically investigated. biological diagnosis requires multiple sites sa ... | 2011 | 24451498 |