Publications

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self-assembled silk sericin/poloxamer nanoparticles as nanocarriers of hydrophobic and hydrophilic drugs for targeted delivery.in recent times self-assembled micellar nanoparticles have been successfully employed in tissue engineering for targeted drug delivery applications. in this review, silk sericin protein from non-mulberry antheraea mylitta tropical tasar silk cocoons was blended with pluronic f-127 and f-87 in the presence of solvents to achieve self-assembled micellar nanostructures capable of carrying both hydrophilic (fitc-inulin) and hydrophobic (anticancer drug paclitaxel) drugs. the fabricated nanoparticles ...200919671963
characterization of fibroin and peg-blended fibroin matrices for in vitro adhesion and proliferation of osteoblasts.silk fibroin protein, isolated from cocoons of the domesticated mulberry silkworm, bombyx mori, finds extensive application in biomaterial design. in this study, poly(ethylene glycol) (peg) 4000 has been used for blending fibroin from both b. mori and antheraea mylitta, the wild tropical non-mulberry silkworm. peg-blended films have shown marked changes from the pure fibroin films with respect to thermal properties and mechanical properties. ft-ir spectroscopy confirmed incorporation of new func ...200919323875
estimation of amino acids, urea and uric acid in tasar silkworm, antheraea mylitta drury.the tasar silkworm, antheraea mylitta drury, andhra local ecorace is an exclusive race of andhra pradesh. it is on the verge of extinction due to difficulty of acclimatisation at breeding and rearing stages. as an attempt to protect this race, a method of total indoor rearing has been done. in this context, the estimation of free amino acids, excretory products- urea and uric acid were compared during the fourth and fifth instars of tasar silkworm, reared under outdoor and indoor conditions. the ...200819297987
silk fibroin protein from mulberry and non-mulberry silkworms: cytotoxicity, biocompatibility and kinetics of l929 murine fibroblast adhesion.silks fibers and films fabricated from fibroin protein of domesticated mulberry silkworm cocoon have been traditionally utilized as sutures in surgery and recently as biomaterial films respectively. here, we explore the possibility of application of silk fibroin protein from non-mulberry silkworm cocoon as a potential biomaterial aid. in terms of direct inflammatory potential, fibroin proteins from antheraea mylitta and bombyx mori are immunologically inert and invoke minimal immune response. st ...200818322779
the promotion of osseointegration of titanium surfaces by coating with silk protein sericin.a promising strategy to influence the osseointegration process around orthopaedic titanium implants is the immobilization of bioactive molecules. this recruits appropriate interaction between the surface and the tissue by directing cells adhesion, proliferation, differentiation and active matrix remodelling. in this study, we aimed to investigate the functionalization of metallic implant titanium with silk protein sericin. titanium surface was immobilized with non-mulberry antheraea mylitta seri ...201323357374
identification of rapd and scar markers associated with yield traits in the indian tropical tasar silkworm antheraea mylitta drury.the tropical tasar silkworm, antheraea mylitta, is a semi-domesticated vanya silk-producing insect of high economic importance. to date, no molecular marker associated with cocoon and shell weights has been identified in this species. in this report, we identified a randomly amplified polymorphic dna (rapd) marker and examined its inheritance, and also developed a stable diagnostic sequence-characterized amplified region (scar) marker. silkworms were divided into groups with high (hcsw) and low ...201223271934
extraction conditions of antheraea mylitta sericin with high yields and minimum molecular weight degradation.although the technique for extracting the bombyx mori sericin has been extensively known, the extraction of sericin from wild-silkworm cocoons is not yet standardized. the aim of this study was to find the optimal conditions for the extraction of sericin from antheraea mylitta cocoons, with high yields and minimum degradation. we attempted to apply various protocols for the extraction of the a. mylitta sericin (ams). among these, we found that the extraction of ams with a sodium carbonate soluti ...201323026092
potential of 2d crosslinked sericin membranes with improved biostability for skin tissue engineering.silk sericin protein is a natural, hydrophilic, macromolecular glycoprotein mainly synthesized in the middle silk gland of the silkworm. it constitutes 25-30% of the silk cocoon. sericin proteins have antioxidant, antimicrobial, uv-resistant properties, promote wound healing and support cell proliferation even in serum-free media. most of the sericin is discarded as waste in silk processing industries. this study aims at improving the mechanical strength and stability of sericin extracted from t ...201222327482
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