| hepatic low density lipoprotein receptor binding and lipid profile in mastomys natalensis during plasmodium berghei infection. | plasmodium berghei infection to mastomys natalensis showed hyper beta-lipoproteinemia. the increase in serum cholesterol is associated with decreased uptake of low density lipoprotein (ldl) by the liver through receptor mediated endocytosis. the membranes prepared from infected m. natalensis exhibit up to 50% decline in high affinity binding sites for human 125i-ldl. significant increases in serum lipids, cholesterol, triglyceride and lipid peroxide (lpo) contents of liver membrane were observed ... | 1989 | 2698856 |
| altered immune response (humoral and delayed-type hypersensitivity reactions) to sheep red blood cells in the course of experimental filarial infections (litomosoides carinii, brugia malayi, acanthocheilonema viteae) of mastomys natalensis. | litomosoides carinii-, acanthocheilonema viteae- or brugia malayi-infected mastomys natalensis were sensitised against sheep red blood cells (srbc) on various occasions after infection to determine the effect of filarial infections on the immune response to a non-filarial antigen. the phagocytic activity of the reticuloendothelial system (res) was controlled in vivo by the elimination of 51cr-labelled srbc. antibody titres against srbc (agglutinating and lytic antibodies) were similar to those o ... | 1989 | 2726721 |
| studies on the activity of the ciba geigy compounds cgp 6140, 20376, 20309 and 21833 against third and fourth stage larvae of onchocerca volvulus. | the effect of four new antifilarial compounds, (cgp 6140, 20376, 20309 and 21833, ciba geigy ltd. basle) on the viability of third and fourth stage larvae of onchocerca volvulus was tested in vitro and in vivo. the motility of the larval stages and the moulting process from the third to the fourth stage were used as parameters for the drug activity in vitro. all four compounds showed good effects in vitro on the moulting rates compared to the controls after incubation at different concentrations ... | 1989 | 2740728 |
| 19s and 7s antibody response of mastomys natalensis in experimental filarial (litomosoides carinii, acanthocheilonema viteae, brugia malayi, b. pahangi) infections. | specific total antibody (ab), 19s and 7s ab levels in the serum of m. natalensis were investigated after infection with l. carinii, a. viteae, b. malayi and b. pahangi for period of about 500 days p.i., using elisa (homologous adult antigen) and indirect immunofluorescence tests (iift: homologous adult and microfilariae antigen). total ab levels in l. carinii infected animals rose moderately during prepatency maximum levels occurred during patency. the response during prepatency was stronger in ... | 1989 | 2781895 |
| cloning and characterization of a papillomavirus associated with papillomas and carcinomas in the european harvest mouse (micromys minutus). | individuals in a colony of european harvest mice (micromys minutus) were diagnosed with a variety of skin tumors including papillomas, trichoepitheliomas, and sebaceous carcinomas. papillomavirus group-specific antigens and viruslike particles were detected in the papillomas. a 7.6-kilobase supercoiled circular dna, which was cleaved once by ecori, was visualized in papilloma extracts by low-stringency southern blot hybridization with a bovine papillomavirus type 2 probe. the molecule was cloned ... | 1988 | 2824849 |
| comparison of cortical adrenergic, cholinergic and benzodiazepine receptors between albino rat and desert rat (mastomys natalensis) using radioreceptor binding. | cortical alpha-adrenergic, beta-adrenergic, cholinergic (muscarinic) and benzodiazepine receptors have been studied in the albino rat and mastomys natalensis (desert rat) using radioligand binding. scatchard analysis was performed to determine affinity (kd) and density (bmax) of receptors. compared to the albino rat, the desert rat was found to have higher affinity and density of alpha-adrenergic receptors. beta-adrenergic receptors had similar kd in both species but bmax was significantly lower ... | 1988 | 2841694 |
| effect of lanosterol on the susceptibility of mastomys natalensis to entamoeba histolytica infection. | | 1985 | 2863883 |
| stage-specific homocytotropic antibody response of mastomys natalensis to dipetalonema viteae infection. | | 1987 | 2884834 |
| [stimulation of the development of chloroquine-sensitive and -resistant strains of plasmodium falciparum by cocultivation with mastomys natalensis cells]. | | 1988 | 3050413 |
| stage-specific protective immunity to microfilariae of litomosoides carinii in mastomys natalensis. | | 1988 | 3058997 |
| litomosoides carinii in rodents: immunomodulation in potentiating action of diethylcarbamazine. | the antifilarial activity of combination of diethylcarbamazine (dec) and an immunomodulator, n-palmitoylmuramyl-l-alanyl-d-isoglutamine (np-mdp) was evaluated against litomosoides carinii in cotton rat (sigmodon hispidus) and mastomys natalensis. dec was used at 6 mg/kg in cotton rat whereas it was 75 mg/kg x 5 days in mastomys. the immunomodulator was administered at 62.5 to 500 micrograms/animal x 2 days. combination therapy with optimum dose of immunomodulator resulted in prolonged and signif ... | 1988 | 3075985 |
| morphological studies on the muscle cysts of sarcocystis dirumpens (hoare 1933) häfner and matuschka 1984 in several host species revealing endopolygeny in metrocytes. | muscle cysts from rodents (mastomys natalensis, mus musculus, rattus norvegicus, meriones unguiculatus, phodopus sungorus) experimentally infected with sarcocystis dirumpens were examined by light and electron microscopy. the corrugated primary wall showed a pattern of densely arranged invaginations surrounded by minute bleb-like evaginations. true protrusions were absent. the length of the blebs and the thickness of the primary wall varied insignificantly but not remarkable host-dependent morph ... | 1986 | 3092488 |
| the ngf and kallikrein genes of mouse, the african rat mastomys natalensis and man: their distribution and mode of expression in the salivary gland. | the kallikrein genes and their expression in the salivary glands of mouse, the african rat mastomys natalensis and human were compared. the mastomys kallikrein genes comprise a family of genes similar to those of mouse. androgen markedly enhances transcription of glandular nerve growth factor (ngf) and kallikrein in both male and female mastomys suggesting the presence of testosterone regulated kallikrein genes for growth factor precursor-processing in both sexes. in contrast, although a kallikr ... | 1988 | 3133079 |
| stage-specific antibody response of mastomys natalensis during the course of dipetalonema viteae infection. | stage-specific haemagglutinating (ha) and precipitin antibodies (pa) to infective larvae (l3), adult worms and microfilariae (mf) have been demonstrated in sera of mastomys natalensis during the course of dipetalonema viteae infection using indirect haemagglutination (iha) and ouchterlony's gel-diffusion tests. l3-specific ha antibody titre was shown to be quite low and lasted for shorter period whereas adult-specific antibody response was significantly higher and persisted for longer duration ( ... | 1988 | 3143649 |
| status of biogenic amines in lungs of mastomys natalensis during development of brugia malayi infection. | | 1988 | 3182033 |
| the high molecular weight nerve growth factor complex from mastomys natalensis differs from the murine nerve growth factor complex. | both the male and the female of mastomys natalensis, an african rat, have high levels of nerve growth factor (ngf) in their submaxillary glands. mastomys high molecular weight (hmw) ngf was purified by gel filtration and ion-exchange chromatography and was compared with hmw ngf from the male mouse submaxillary gland. mastomys hmw ngf sediments as a 5s species, does not exhibit esterase activity, and is more difficult to dissociate at acid ph than mouse 7s ngf. the biological activity could be is ... | 1988 | 3196680 |
| antifilarial activities of benzazole derivatives. 2. microfilaricidal effects against litomosoides carinii, acanthocheilonema. vitae, brugia malayi and b. pahangi in mastomys natalensis. | the spectrum of antimicrofilarial activities of eighteen 2-tertbutylbenzazole derivatives was evaluated comparatively in mastomys natalensis infected with litomosoides carinii, acanthocheilonema viteae, brugia malayi or b. pahangi. the minimal effective dose (dem) against microfilariae (greater than 95% reduction of microfilariae counts in the peripheral blood) was determined on day 3 (dem-3), on day 7, 14, 21, 28 and 42 (dem-7, dem-14, dem-21, dem-28 and dem-42) after the first treatment. all c ... | 1988 | 3227232 |
| molecular cloning of a cdna encoding the nerve growth factor precursor from mastomys natalensis. | mastomys natalensis is an african rat that has high levels of nerve growth factor (ngf) in its submaxillary glands. like in the mouse, mastomys ngf is found as a high-molecular-weight complex. however, the mastomys complex differs from the mouse complex, in that the gamma-subunit is either missing or is less tightly bound in the mastomys ngf complex. in the mouse, the gamma-subunit has been implicated in the processing of the beta-ngf precursor. the possible lack of gamma-subunits in the mastomy ... | 1988 | 3234767 |
| macrofilaricidal activity of oral flubendazole on brugia pahangi. | the macrofilaricidal effect of orally administered flubendazole on brugia pahangi was studied in the multimammate rat, mastomys natalensis. a micronized formulation was incorporated in the routine feed for 2 weeks, starting 16 weeks after infection. in the treated rats the microfilarial density dropped to zero 20 weeks after infection, whereas it remained high in untreated animals. when killed between 40 and 41 weeks after infection, the treated group yielded a mean of 2 male and 0.16 female wor ... | 1988 | 3256991 |
| studies on the comparative gametocytaemia of p. berghei (nk 65) in male and female mastomys natalensis. | | 1987 | 3326752 |
| antifilarial activities of benzazole derivatives. 1. macrofilaricidal effects against litomosoides carinii, dipetalonema viteae, brugia malayi, and b. pahangi in mastomys natalensis. | eighteen 2-tert-butyl-benzazole derivatives were evaluated comparatively as macrofilaricidal agents against l. carinii (l.c.), d. viteae (d.v.), b. malayi (b.m.) and b. pahangi (b.p.). upon repeated treatment (once daily) for five consecutive days the eight benzoxazole derivatives were invariably less potent than the corresponding benzothiazole derivatives. the minimal curative dose (dcm) of the benzoxazoles varied depending on the species and on the chemical structure between 25 and 100 mg/kg p ... | 1988 | 3387822 |
| dipetalonema viteae in mastomys natalensis: effect of pregnancy and lactation on establishment and course of infection. | the susceptibility of hosts to filarial infection during pregnancy and lactation was studied using dipetalonema viteae in mastomys natalensis as working model. though no difference in prepatency could be observed yet significantly higher density of microfilaraemia than controls was detected in both pregnant and lactating groups. extended duration of patency was also found in both pregnant and lactating animals. on autopsy, animals exposed at the time of pregnancy or lactation revealed significan ... | 1988 | 3387824 |
| response of dipetalonema viteae in mastomys natalensis to some known antifilarials. | | 1988 | 3403011 |
| an analysis of stereotyped behaviour in mastomys natalensis. | the stereotyped behaviour was analysed in mastomys natalensis, a species of desert rat recently introduced in laboratory practice. the components of stereotyped behaviour were similar to rat characterised by repetitive sniffing, rearing, licking, head movements and biting. apomorphine (0.5-2.0 mg/kg), amphetamine (2.5-10 mg/kg), methylphenidate (10-30 mg/kg) and adamantanamine (10-50 mg/kg) administered intraperitoneally, induced stereotyped behaviour in dose-dependent manner. positive response ... | 1988 | 3412495 |
| effect of cyclosporin a and some derivatives in litomosoides carinii-infected mastomys natalensis. | litomosoides carinii-infected mastomys natalensis were treated 85 days post infection with cyclosporin a (cya) or 8 derivatives with different immunosuppressive capacities. cya (oral doses of 5 x 25 mg/kg, 5 x 50 mg/kg, 5 x 80 mg/kg on consecutive days) reduced parasitaemia levels in a dose dependent way, beginning 3 weeks after first drug administration. using 5 x 50 and 5 x 80 mg/kg animals were free from circulating microfilariae on the day of necropsy (day 56). derivatives were administered ... | 1987 | 3437108 |
| detection of circulating and urinary antigens in mastomys natalensis experimentally infected with brugia malayi, brugia pahangi, or litomosoides carinii. | the time-course of the detection of circulating and urinary filarial antigens was followed with a 2s-irma assay, using a mouse monoclonal antibody raised against brugia malayi larvae, in mastomys natalensis experimentally infected with brugia malayi, brugia pahangi, or litomosoides carinii. in the prepatent phase of the infections, filarial antigen was detected 4-7 weeks before microfilariae appeared in the peripheral blood. moreover, the sensitivity of the test was greater with urine than with ... | 1987 | 3438300 |
| gastrin and the trophic control of gastric mucosa. | gastrin is a trophic stimulant of the acid producing gastric mucosa. experiments have been carried out in rats, in which chronic states of either low or high serum gastrin levels were induced by surgical manipulation or drug treatment. a relationship between circulating gastrin and a trophic effect could be demonstrated in the oxyntic mucosa, but not in the pancreas and small intestine. endocrine cells in the oxyntic mucosa (the ecl cells and a-like cells) are among the target cells for the trop ... | 1986 | 3460169 |
| immunity to litomosoides carinii in mastomys natalensis. ii. effects of chemotherapeutically abbreviated and postpatent primary infections on challenges with various stages of the parasite. | naive mastomys natalensis, litomosoides carinii-infected m. natalensis at a postpatent stage of the infection and l. carinii-infected m. natalensis treated chemotherapeutically with furazolidone (fur), fur and diethylcarbamazine (fur/dec) or amoscanate (amos) were challenged by either injection or implantation of 40 third stage larvae (l3, s.c.), 40 fourth stage larvae (l4, 16 days old, i.p.), 20 male and 20 female preadult worms (36 days old, i.p.), 12 adult female worms (i.p.) or 6 x 10(6) mic ... | 1986 | 3541424 |
| dipetalonema viteae infection in three species of rodents: species specific patterns of the antibody response. | groups of jirds (meriones unguiculatus), multimammate rats (mastomys natalensis) and golden hamsters (mesocricetus auratus) were infected with third stage larvae (l3) of dipetaloneam viteae and the course of infection was followed until 20 weeks post infection. worm growth was best and microfilaraemia was high and long lasting in jirds and in multimammate rats, whereas golden hamsters were poor hosts as measured by these parameters. the igg and igm antibody responses of the species were compared ... | 1987 | 3550602 |
| lysosomal enzymes in mastomys natalensis during different stages of infection with brugia malayi. | | 1987 | 3583352 |
| reaginic and homocytotropic igg antibody response of mastomys natalensis in experimental infections of filarial parasites (litomosoides carinii, dipetalonema viteae, brugia malayi, b. pahangi). | reaginic and homocytotropic igg antibodies in sera using passive cutaneous anaphylaxis (pca) test and antigen from litomosoides carinii were followed in mastomys natalensis, infected with l. carinii, dipetalonema viteae, brugia malayi or b. pahangi. groups of animals with infections of various ages so as to cover a total infection period of up to 300 to 420 days post-infection (p.i.), depending on the species of parasites, were bled at 1- to 3-week intervals over periods of 50-112 days. in addit ... | 1987 | 3588585 |
| histopathological and electron microscopical studies in litomosoides carinii infected mastomys natalensis. | | 1987 | 3591109 |
| morphological alterations in female litomosoides carinii after treatment with two benzthiazole derivatives in vivo. | multimammate rats (mastomys natalensis) infected with litomosoides carinii were treated 65 days after infection with a single oral dose of 50 mg/kg of cgp 20308 or cgp 20376 (ciba geigy limited, basel). autopsies were performed between 1 and 28 days after treatment. the numbers of worms and the numbers and condition of intrauterine developmental stages in the females were determined. other female filariae were investigated by transmission electron microscopy (tem). female filariae were observed ... | 1987 | 3602833 |
| effect of ivermectin in dipetalonema viteae and litomosoides carinii infections of mastomys natalensis. | in d. viteae infected m. natalensis oral or subcutaneous (s.c.) treatment with ivermectin on 5 consecutive days with at least 0.05 mg/kg and single dose treatment with 0.1 mg/kg caused a 100% reduction of microfilaraemia throughout the investigation period of 42 days. using lower doses (lowest dose used 5 x 0.003 mg/kg) animals were free from circulating microfilariae at least until day 7. the drug was active against adult worms. treatment with doses of 5 x 0.2 mg/kg and above resulted in 81-93% ... | 1987 | 3629133 |
| effect of ivermectin on serum dependent cellular interactions to dipetalonema viteae microfilariae. | the effects of ivermectin (iv) on the filarial infection has been investigated using dipetalonema viteae--mastomys natalensis model system. in vitro, iv (3 micrograms/ml) had no effect on the microfilariae (mf) in the presence or absence of serum from normal or infected mastomys (nms, ims). however, the sera promoted cell-mediated cytotoxicity with macrophages or eosinophils to the mf when iv was added at 3 ng/ml. sera isolated from normal or infected mastomys after subcutaneous treatment with i ... | 1987 | 3629134 |
| characterization of kenyan leishmania spp. and identification of mastomys natalensis, taterillus emini and aethomys kaiseri as new hosts of leishmania major. | a survey to examine rodents for leishmanias was initiated in the perkerra settlement scheme, marigat, baringo district, kenya, 789 rodents of ten different species were trapped and examined. leishmanial parasites were isolated from the spleen and liver of 17 animals of five different species: seven from tatera robusta, five from arvicanthis niloticus, two from mastomys natalensis, two from taterillus emini and one from aethomys kaiseri. these were identified as l. major by enzyme electrophoresis ... | 1986 | 3632097 |
| homocytotropic antibodies of the multimammate rat, mastomys natalensis. demonstration and characterization of 2 types classified as ige and igg3. | | 1987 | 3673297 |
| experimental plague infection in south african wild rodents. | susceptibility studies were undertaken to determine the response of some south african wild rodent species to experimental plague (yersinia pestis) infection. a degree of plague resistance was found in three gerbil species captured in the plague enzootic region of the northern cape province, these being the namaqua gerbil, desmodillus auricularis, (ld50 1 x 10(6) organisms), the bushveld gerbil, tatera leucogaster, (ld50 9.1 x 10(5)) and the highveld gerbil, t. brantsii (ld50 4 x 10(2)). animals ... | 1986 | 3701038 |
| unresponsiveness of lymphocytes in patent filarial infection: modulation by diethylcarbamazine. | the lymphocytes of lymph nodes and spleen of mastomys natalensis infected with litomosoides carinii were unresponsive to specific filarial antigens during patent stage of the infection. the effect of diethylcarbamazine (dec) on these responses has been investigated. dec administered orally at 150 mg/day for 5 days to the animals reduced markedly the circulating levels of microfilariae. at this stage the lymphocyte proliferative responses improved to specific microfilarial antigens. on follow-up ... | 1986 | 3704471 |
| effect of some known antifilarials on the immune responses of mastomys natalensis infected with brugia malayi. | | 1986 | 3710542 |
| stereotyped behaviour and striatal dopamine receptors in albino rat and the desert rat (mastomys natalensis): a comparative study. | | 1986 | 3770814 |
| [potential filaricides. suramin analogs]. | a series of suramin analogues has been synthesized in which the methyl groups of suramin have been replaced by hydrogen, alkyl, phenyl, and fluoro substituents, or which contain more than two methyl groups. the substances have been screened against dipetalonema viteae in meriones unguiculatus, litomosoides carinii in sigmodon hispidus and l. carinii in mastomys natalensis, respectively. small structural modifications have a marked influence on the antifilarial activity. there are marked differen ... | 1986 | 3778551 |
| brugia malayi: rat cell interactions with infective larvae mediated by complement. | albino rat macrophages and neutrophils, in the presence of fresh normal rat serum as a source of complement, adhered to and promoted killing of brugia malayi infective larvae in vitro. eosinophils, by themselves, were marginally cytotoxic at a high cell-target ratio but promoted cytotoxicity when mixed with macrophages. eosinophil culture supernatants enhanced the macrophage mediated killing of infective larvae. the complement of fresh normal rat serum was found to act by the alternate pathway. ... | 1986 | 3780928 |
| histology of adult brugia malayi. | two male and two female brugia malayi were collected from mastomys natalensis, and cross sections from various regions of these worms were studied. the body wall of the female worm is thin throughout its length, whereas in the midbody and posterior region of the male worm the somatic muscles form a thick layer. in both sexes the intestine is thickest immediately behind the oesophagus and tapers posteriorly. the lumen was empty in all sections. in both genital tubes of the female worm a successiv ... | 1986 | 3787124 |
| the effect of diethylcarbamazine on microfilariae of litomosoides carinii in vitro and in vivo. | culture-derived litomosoides carinii microfilariae (mff) were used in in vitro and in vivo systems to investigate the effect of diethylcarbamazine (dec) on these mff. in vivo: male rats, mastomys natalensis, all of the same age, were injected intrathoracically (12) or intraperitoneally (36) with 10(3) or 10(4) mff. after 30 min one half of each group of rats was given dec per os. at 30, 60, and 120 min after dec administration, two rats from the treated and two from the untreated group were bled ... | 1986 | 3799010 |
| a prospective study of the epidemiology and ecology of lassa fever. | in studies of lassa fever in sierra leone, the prevalence of human antibody to lassa virus ranged from 8% to 52%. mastomys natalensis, the reservoir of lassa virus, constituted 50%-60% of the rodents captured in houses but only 10%-20% of those captured in surrounding agriculture and bush areas (chi 2 = 90.2, p less than 10(-6), df = 1), a finding suggesting that houses are the most-important location for transmission of lassa virus. viral infection of mastomys from houses ranged from 0% to 80%. ... | 1987 | 3805771 |
| experimental infections of the multimammate rat (mastomys natalensis) with leishmania donovani and leishmania major. | the susceptibility of the multimammate rat, mastomys natalensis, to experimental infections with leishmania donovani and l. major was examined. inoculations of l. major promastigotes into the skin resulted in nonulcerating lesions in which parasites could be detected for more than 30 weeks later. intravenous inoculations of l. donovani promastigotes produced visceral infections characterized by a continuing increase in splenic parasite burdens and liver parasite burdens which peaked during the f ... | 1987 | 3826485 |
| sequential changes in the antibody response of mastomys natalensis consequent to brugia malayi infection. | | 1985 | 3894227 |
| synthesis and anthelmintic activity of 5(6)-(benzimidazol-2-ylcarbamoyl) and (4-substituted piperazin-1-yl)benzimidazoles. | the synthesis of alkyl 5(6)-(benzimidazol-2-ylcarbamoyl)benzimidazole-2-carbamates (6, 7), and alkyl 5(6)-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates (31-40) has been carried out. when the compounds were tested for their anthelmintic activity against ancylostoma ceylanicum in hamsters, hymenolepis nana in rats, litomosoides carinii in cotton rats, and dipetalonema viteae in mastomys natalensis, methyl 5(6)-(4-benzoylpiperazin-1-yl)benzimidazole-2-carbamate (31), methyl 5(6)-[4-(2-fu ... | 1985 | 3906129 |
| hepatic acid hydrolases of albino rats, mastomys natalensis and albino mice during plasmodium berghei infection. | changes in liver acid hydrolase activities during the infection of albino rats, mastomys or mice with plasmodium berghei are described. b-glucosidase, b-galactosidase and n-acetyl-b-d-glucosaminidase exhibited widely different responses with acid phosphatase and cathepsin-b the least responsive and are likely to be causally related to immunity of animals. | 1985 | 3921400 |
| development of infective larvae of onchocerca volvulus in diffusion chambers implanted into mastomys natalensis. | diffusion chambers containing vector-derived infective larvae of o. volvulus were implanted into male mastomys natalensis and removed after periods up to 100 days. nearly all chambers contained motile living parasites. after two weeks lengths and diameters of the larvae had increased significantly and after 100 days one juvenile worm showed well developed papillae at the posterior end. | 1985 | 4023553 |
| reaginic and homocytotropic igg antibodies in schistosoma mansoni infected mastomys natalensis: time courses in untreated infections and after chemoprophylactic and chemotherapeutic treatment. | mastomys natalensis were infected percutaneously with 250 cercariae of schistosoma mansoni and treated effectively with 5 x 50 mg amoscanate/kg body-weight 12-16 (i), 28-32 (ii), 56-60 (iii) and 101-105 days p.i. (iv) respectively. levels of reaginic antibodies (rab) and homocytotropic igg antibodies (gab) were assessed by passive cutaneous anaphylaxis tests (pca) and compared with those in infected, untreated animals. in untreated animals rab were first detected in the 6th week p.i. maximum tit ... | 1985 | 4031450 |
| hepatic microsomal alterations during dipetalonema viteae infection in mastomys natalensis. | | 1985 | 4039707 |
| studies on the causation of adverse reactions in microfilaraemic host following diethylcarbamazine therapy (dipetalonema viteae in mastomys natalensis). | the mechanism of the adverse reaction in microfilaraemic subjects following diethylcarbamazine (dec) therapy has remained an enigma. to study the mechanisms involved mastomys natalensis infected with dipetalonema viteae have been used. animals showing up to 50 mf/5 cmm of blood did not show any perceptible reactions when treated with the minimum effective dose of 350 mg/kg of dec citrate, while those having more than 80 mf/5 cmm died, suggesting an intensity dependent severity of reactions. infe ... | 1985 | 4039839 |
| immunity to litomosoides carinii in mastomys natalensis. i. effect of immunization with microfilariae and existing primary infections on the parasitaemia after microfilariae injection and challenge infection. | subcutaneous injections of intrauterine stages of litomosoides carinii into mastomys natalensis induced strong immunity to i.v. injected blood microfilariae. immunity, developed after boostering with an i.p. and an i.v. injection of microfilariae, did not totally suppress the parasitaemia of a challenge infection but reduced significantly the microfilaraemia level. no effect was found on number and size of the worms of the challenge infection, the number of microfilariae or the number of leucocy ... | 1985 | 4050030 |
| soleus muscle adenosine-5'-triphosphate (atp) levels in mastomys natalensis with dipetalonema viteae infections: effect of diethylcarbamazine. | adenosine-5'-triphosphate (atp) levels in the soleus muscles of mastomys natalensis during the patent phase of dipetalonema viteae infection were studied. decreased atp levels were found in the infected animals as compared with the uninfected controls. diethylcarbamazine citrate produced an 'anaphylactic reaction' and enhanced microfilaraemia in the infected animals, but did not cause any lowering of the soleus muscle atp in the infected as well as in the uninfected animals. | 1985 | 4081548 |
| immunological and clinical-chemical investigations on blood, urine, and kidney in aging praomys (mastomys) natalensis with spontaneous glomerulonephritis. | | 1972 | 4122173 |
| [capillaria hepatica infection of mastomys natalensis: alterations of enzyme activities in serum (author's transl)]. | | 1974 | 4152645 |
| [experimental study of the activity of the sulphamethoxypyrazine (longum equals kelfizina) with pyrimethamine (daraprim) on the cysts development phase of toxoplasma gondii in mastomys natalensis. further contribution to experimental chemotherapy of toxoplasmosis (author's transl)]. | | 1974 | 4152678 |
| adenocarcinoma and proliferative hyperplasia of the prostate gland in female rattus (mastomys) natalensis. | | 1965 | 4157483 |
| spontaneous thymoma, polymyositis, and serum-autoantibodies to striated muscle in the rodent, subgenus praomys (mastomys) natalensis. similarities to thymoma with myasthenia gravis in man. | | 1968 | 4171846 |
| induction of a high incidence of damage to the x chromosomes of rattus (mastomys) natalensis by base analogues, viruses, and carcinogens. | | 1967 | 4299043 |
| susceptibility of praomys (mastomys) natalensis to the murine sarcoma virus-harvey (msv-h). | | 1968 | 4302086 |
| the carinogenicity of n-hydroxy-n-2-fluorenyl-acetamide and the matabolism of n-2-fluorenyl-acetamide in praomis (mastomys) natalensis. | | 1968 | 4303104 |
| microbodies in experimentally altered cells. ix. the fate of microbodies. | male rats were given 0.25% cpib (ethyl chlorophenoxyisobutyrate) for 4 weeks at which time their liver cells showed the typical increase in number of microbodies (peroxisomes). during the first week after withdrawal of cpib and simultaneous injection of allylisopropylacetamide (aia), an inhibitor of catalase synthesis, the microbody matrix, in peroxidase preparations, showed marked decrease in electron opacity. in liver cells of rats from which cpib was withdrawn but which were not given aia, th ... | 1972 | 4338207 |
| [pathophysiological and toxicological aspects of schistosoma mansoni infection in mastomys natalensis under treatment with hycanthone]. | | 1973 | 4360332 |
| haemoglobin of mastomys natalensis (rattus natalensis). earlier observations on starch gel electrophoretic pattern, column chromatographic fractionation and polypeptide chains separation. | | 1973 | 4747094 |
| [litomosoides carinii infection of mastomys natalensis: alterations of haematological parameters (author's transl)]. | | 1973 | 4770091 |
| [pseudocholinesterases' activity in the kidney. comparative study in the rat and in mastomys (praomys natalensis)]. | | 1973 | 4794624 |
| [litomosoides carinii infection of mastomys natalensis: serological studies with the complement fixation and the indirect haemagglutination test in the course of infection (author's transl)]. | | 1974 | 4833626 |
| lassa virus isolation from mastomys natalensis rodents during an epidemic in sierra leone. | lassa fever is a severe febrile illness of man, first recognized in west africa in 1969. during an epidemic in sierra leone, lassa virus was isolated for the first time from wild rodents of mastomys natalensis. a high prevalence of infected mastomys was found in houses occupied by patients with lassa fever. the data presented provide the first demonstration of an extra-human cycle of lassa virus transmission and suggest that rodent control may be an effective method of limiting the disease. | 1974 | 4833828 |
| [litomosoides carinii infection of mastomys natalensis: relationship between microfilaraemia and adult worm population (author's transl)]. | | 1974 | 4836671 |
| [pathophysiological investigations of schistosoma mansoni infection in mastomys natalensis under chemotherapy with a nitrovinylfuran derivative (sq 18.506) (author's transl)]. | | 1974 | 4839002 |
| notes on the host-parasite relationship during infection of praomys (mastomys) natalensis with the filarial parasite litomosoides carinii. | | 1974 | 4853378 |
| proceedings: mastomys natalensis as a host for dipetalonema viteae. | | 1974 | 4856425 |
| chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 4. the prophylactic and suppressive activity of suramin. | | 1974 | 4857965 |
| hematopoietic neoplasms and related conditions in praomys (mastomys) natalensis. | | 1969 | 4885322 |
| [experimental infection in mastomys natalensis (smith 1834) with trypanosoma species of the lewisi-congolense and brucei-evansi groups]. | | 1971 | 4946451 |
| [precipitating antibodies in the serum of mastomys natalensis in the course of litomosoides carinii infection]. | | 1970 | 4993040 |
| the susceptibility of rodents to schistosome infection, with special reference to schistosoma haematobium. | in this investigation the susceptibility of several species of rodents-praomys (mastomys) natalensis, saccostomus campestris, arvicanthus niloticus, aethomys chrysophilus, tatera brantsi and the white mouse (saimr 200 strain)-to schistosoma haematobium was determined and the pathology studied. from the results it is clear that these rodents are susceptible to infection with schistosoma haematobium. for various reasons, notably adaptability to laboratory conditions, the most suitable as laborator ... | 1966 | 5297005 |
| chemotherapeutic studies on experimental schistosoma mansoni infection of mastomys natalensis. | comparative chemotherapeutic studies on various well known or newly developed schistosomicidal agents have been carried out in mastomys natalensis experimentally infected with schistosoma mansoni. hycanthone, lucanthone, niridazole, mirasan, the experimental compounds hoe s616, hoe s683, hoe s688, and hoe s201, tartar emetic, stibophen, and stibocaptate acid have shown marked activity when administered in standard daily dosages for 5 consecutive days. dehydroemetine and bis (p-rosaniline pamoate ... | 1971 | 5317444 |
| chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 1. the filaricidal action of 2,6-bis-benzimidazoles. | the antifilarial action of 2-[2-(4-hydroxyphenyl)-6-benzimidazolyl]-6-(1-methyl-4-piperazyl) benzimidazole (hoe 33258) was investigated in mastomys natalensis infected with litomosoides carinii. the subcutaneous administration of hoe 33258 in a single daily dose for 5 consecutive days, or at other intervals, produced, depending on the dosage, a rapid reduction in the number of microfilariae in the circulating blood. the reduction amounted to more than 90% within 7-14 days after the treatment was ... | 1971 | 5317445 |
| chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 2. the activity of drugs against microfilariae. | comparative investigations of the chemotherapeutic activity of various filaricidal compounds and other anthelmintics were made with litomosoides carinii infections in mastomys natalensis, special consideration being given to the microfilaricidal activity of the compounds. diethylcarbamazine, cyclohexanecarboxylic acid-n-methylpiperazide citrate (hoe 28637a), tetrahydropyranecarboxylic acid-n-methylpiperazide citrate (hoe 29691a), (+/-)-tetramisole, (-)-tetramisole (levamisole), and metrifonate p ... | 1971 | 5317446 |
| chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 3. the activity of drugs against adult parasites. | comparative studies of the chemotherapeutic activity of various filaricides were carried out and the results in litomosoides carinii infections of mastomys natalensis were analysed with special reference to macrofilaricidal activity. the administration of suramin in daily subcutaneous doses of 40 mg per kg of body weight for 5 consecutive days showed marked activity against macrofilariae and killed the adult worms within 6 weeks after the beginning of treatment. the microfilarial count of the ci ... | 1971 | 5317447 |
| [the albumin-globulin ratio in the serum of mastomys natalensis (smith, 1834) in the coruse of infection with litomosoides carinii]. | | 1970 | 5436819 |
| the efficacy of various anthelmintics against the parasitic larval stages of ancylostoma caninum in mastomys natalensis. | | 1970 | 5485196 |
| karyologic and autoradiographic studies of the chromosomes of rattus (mastomys) natalensis. | | 1968 | 5653740 |
| [on the host-parasite relationship in mastomys natalensis (smith, 1834)]. | | 1968 | 5719585 |
| some developments in techniques for the study of the rodent filarial parasite litomosoides carinii. i. a preliminary comparison of the host effciency of the multimammate rat, praomys (mastomys) natalensis, with that of the cotton rat, sigmodon hispidus. | | 1968 | 5729256 |
| some developments in techniques for the study of the rodent filarial parasite litomosoides carinii. ii. a quantitative method for the culture of the mite ornithonyssus bacoti and for the routine transmission of litomosoides carinii to praomys (mastomys) natalensis. | | 1968 | 5729257 |
| [infection experiments with the cotton rat filaria litomosoides carinii in mastomys natalensis (smith, 1834)]. | | 1968 | 5746888 |
| [experimental infections with intestinal nematodes, cestodes and trematodes in mastomys natalensis (smith, 1834)]. | | 1968 | 5746894 |
| experimental infection of the african multimammate mastomys, rattus (mastomys) natalensis, with the minute stomach worm trichostrongylus axei. | | 1968 | 5757724 |
| fine structure of the gastric mucosa of the cancer-producing african rodent, rattus (mastomys) natalensis. i. normal general structure. | | 1966 | 5925779 |
| degenerative joint disease in praomys (mastomys) natalensis. | | 1967 | 6023697 |
| erythrocyte membrane-bound enzymes in mastomys natalensis during plasmodium berghei infection. | the pattern of activity of certain membrane-associated enzymes was followed in the erythrocytes of plasmodium berghei-infected mastomys natalensis. parasitized erythrocytes were separated from non-parasitized populations by percoll-density gradient centrifugation. the activity of adenylate cyclase was markedly increased while those of atpase, acid phosphatase, beta-glucuronidase and n-acetyl-beta-d-glucosaminidase were considerably decreased in the membrane preparations of parasitized erythrocyt ... | 1984 | 6087778 |
| filarial infections of mastomys natalensis and their relevance for experimental chemotherapy. | experimental filarial infections of mastomys natalensis, strain gra giessen, with litomosoides carinii, dipetalonema viteae, brugia malayi (subperiodic), and brugia pahangi were compared. mean prepatent periods of 52, 57, 107, and 73 days p.i. were observed after subcutaneous inoculation of 40, 50, 85, and 70 infective larvae of l. carinii, d. viteae, b. malayi, and b. pahangi, respectively, in the neck region. all of the l. carinii, d. viteae, and b. pahangi infected mastomys showed a regularly ... | 1981 | 6118036 |
| chemical carcinogenesis by the two-stage protocol in the skin mastomys natalensis (muridae) using topical initiation with 7,12-dimethylbenz(a)anthracene and topical promotion with 12-0-tetradecanoylphorbol-13-acetate. | the long-term (34 weeks) topical administration of 7,12-dimethylbenz(a)anthracene (dmba) to the skin of male and female mastomys induced a broad spectrum of benign and malignant tumors in all animals treated. in a two-stage carcinogenesis experiment with topical initiation with dmba and topical promotion with tpa, 50% of the animals developed both benign and malignant skin tumors. in general, benign tumors occurred between weeks 15 and 25, whereas malignant tumors were seen 40 weeks after initia ... | 1981 | 6119833 |
| on the persistence of human serum resistance and isoenzyme patterns of trypanozoon in experimentally infected pigs. | 'mini-pigs' were infected with salivarian trypanozoon clones to examine the persistence and stability of the human serum resistance [blood incubation infectivity test (biit)] and isoenzyme characteristics during infection in a new host. a stock regarded as trypanosoma brucei, derived from a domestic pig in the ivory coast, retained its biit negative (serum sensitive), alanine aminotransferase (alat) and peptidase 2 (pep 2) characteristics throughout 343 days of infection in pigs. similarly there ... | 1981 | 6123244 |
| diethylcarbamazine dependent, complement mediated, adherence and cytotoxicity of cells on microfilariae of litomosoides carinii. | diethylcarbamazine (dec) induced dose dependent adherence of normal spleen cells from mastomys natalensis to microfilariae of l. carinii in the presence of serum from mastomys infected with l. carinii or normal serum. the effect could be also induced, using fresh, normal human serum and human blood leucocytes. the responsible serum factor was heat labile (56 degrees c, 30 min) and was eliminated from the sera by pretreatment with inulin. the activity could be reconstituted by normal serum. cell ... | 1983 | 6136173 |