| the origin and genetic relationships of the baikal seal, phoca sibirica, by restriction analysis of mitochondrial dna. | the origin and genetic relationships of the baikal seal, phoca sibirica, were studied by restriction fragment length polymorphism analysis of mitochondrial dna (mtdna). using 17 different six-base recognition restriction endonucleases, we examined 98 baikal seals, and two other related species, the ringed seal, p. hispida, (n=87), and the caspian seal, p. caspica, (n=94). analysis revealed the existence of 87 mtdna haplotypes in the total of 279 specimens. the haplotypes of each species were div ... | 2003 | 14624043 |
| in vitro and in silico evaluations of binding affinities of perfluoroalkyl substances to baikal seal and human peroxisome proliferator-activated receptor α. | in this study, we assessed the binding affinities of perfluoroalkyl substances (pfass), including perfluoroalkyl carboxylates (pfcas) and perfluoroalkyl sulfonates (pfsas), to the ligand-binding domains (lbds) of baikal seal ( pusa sibirica; bs) and human (h) peroxisome proliferator-activated receptor alpha (pparα). an in vitro competitive binding assay showed that six pfcas and two pfsas could bind to recombinant bs and hpparα lbd proteins in a dose-dependent manner. the relative binding affini ... | 2019 | 30649875 |
| in vitro assessment of activation of baikal seal ( pusa sibirica) peroxisome proliferator-activated receptor α by polybrominated diphenyl ethers. | we investigated the baikal seal ( pusa sibirica) peroxisome proliferator-activated receptor α (bspparα) transactivation potencies of polybrominated diphenyl ethers (pbdes) using an in vitro bspparα reporter gene assay. bde47, bde99, and bde153 induced bspparα-mediated transcriptional activities in a dose-dependent manner. to compare bspparα transactivation potencies of pbdes, perfluorooctanoic acid (pfoa)-based relative potencies (reps), a ratio of 50% effective concentration of pfoa to the test ... | 2018 | 30212190 |
| past and present mercury accumulation in the lake baikal seal: temporal trends, effects of life history, and toxicological implications. | despite global efforts to reduce anthropogenic mercury (hg) emissions, the timescale and degree to which hg concentrations in the environment and biota respond to decreased emissions remain challenging to assess or predict. in the present study we characterize long-term trends and life-history patterns in hg accumulation and toxicological implications of hg contamination for a freshwater seal from one of the world's largest lakes (lake baikal, siberia, russia) using contemporary tissues and arch ... | 2018 | 29341225 |