| trypanosoma lewisi: immune spleen cell transfer in rats. | | 1972 | 4559020 |
| comparative histochemical studies of rats infected with a pathogenic and nonpathogenic trypanosome. | histochemical variations in tissues from rats inoculated with trypanosoma lewisi and trypanosoma rhodesiense were investigated. during peak parasitemia, the liver of rats inoculated with t lewisi showed increased glycogen distribution. however, glycogen depletion was noted in the liver and spleen of animals inoculated with living cells of t rhodesiense. depletion was very apparent from day 4 to day 10. throughout the period of observation, only a small amount of lipid infiltration occurred in ti ... | 1991 | 1875425 |
| interaction of nutrition and infection: effect of copper deficiency on resistance to trypanosoma lewisi. | the copper-deficient rat-trypanosome system was used to study copper deficiency in sprague dawley rats infected with trypanosoma lewisi. throughout the observational period, animals on the deficient diet had lower plasma and liver copper concentrations compared with complete and pair-fed animals. in all dietary groups, the food intake and body weight changes of rats inoculated with t lewisi showed significant increases over the noninoculated controls. the rate of these indices were significantly ... | 1992 | 1507261 |
| trypanosoma lewisi: termination of pregnancy in the infected rat. | | 1973 | 4570981 |
| trypanosoma lewisi: cell populations and antibody formation in riboflavin deficient rats. | | 1973 | 4574318 |
| transport of nucleosides in trypanosoma lewisi. | | 1973 | 4575538 |
| cellular responses to phase fractions of trypanosoma lewisi. | infections by trypanosoma lewisi are characterized by hyporesponsiveness of the immune system during the early phase of parasitaemia. blastogenic response of normal rat spleen cells to amphiphilic and hydrophilic components of triton x-114 solubilized epimastigote forms of t. lewisi which characterizes the early phase of infection showed that suppression of responses to mitogens concanavalin a (con-a) and lipopolysaccharide (lps) occurred exclusively with the amphiphilic fraction that consists o ... | 1992 | 1557227 |
| a putative flagellar ca2(+)-binding protein of the flagellum of trypanosomatid protozoan parasites. | | 1990 | 2198539 |
| trypanocidal drugs and their effect on parasitaemia, specific igg production and protective immunity in rats infected with trypanosoma lewisi. | in rats infected with trypanosoma lewisi, parasitaemia normally resolves by day 32; thereafter, the rodents become solidly immune to re-infection. rats treated on day 5 of infection with a single i.m. dose of 35 mg/kg of the trypanocidal drug ethidium bromide (eb) had recovered from parasitaemia by day 12, whereas berenil (be) given at 100 mg/kg, more than twice the recommended dose, had no effect on parasitaemia. however, rats treated for 4 consecutive days beginning on day 5 of infection with ... | 1992 | 1589433 |
| chitinase secreted by leishmania functions in the sandfly vector. | leishmania major parasites ingested with host blood by the sandfly phlebotomus papatasi multiply confined within the peritrophic membrane. this membrane consists of a chitin framework and a protein carbohydrate matrix and it is secreted around the food by the insect midgut. histological sections of infected flies show lysis of the chitin layer in the anterior region of the peritrophic membrane that permits the essential forward migration of a concentrated mass of parasites. both the location and ... | 1991 | 1682935 |
| suppressor and protector factors derived from trypanosoma lewisi. | trypanosoma lewisi is a specific protozoan blood parasite of rats. normal rats infected 2 h after treatment with plasma from day 8 irradiated (8.5 gy) infected rats had significantly higher parasitaemia; in contrast, animals infected 7 days post-plasma treatment were significantly protected. trypanolytic and ablastic antibodies could be demonstrated in the serum of normal rats treated with the plasma; the trypanolytic antibodies were stage-specific. suppression of normal rat splenocyte responses ... | 1991 | 1774111 |
| survival and growth pattern of trypanosoma lewisi in two heterologous hosts: albino mouse and guinea-pig. | | 1972 | 4587804 |
| preliminary study of a trypanosoma lewisi-like parasite of rats in chiang mai, thailand. | | 1973 | 4588621 |
| interaction of trace metal contaminants on hematological responses: influence of infection with trypanosoma lewisi. | the influence of trace metal contaminants (lead, cadmium, and mercury) on sprague-dawley rats was investigated to determine whether subclinical levels of these metals might have adverse effects on the host's ability to respond to an infective agent.in the present study, a trace metal contaminant-trypanosome system was employed to observe the hematological changes in rats infected with trypanosoma lewisi. the animal groups were: (1) lead (pb), (2) cadmium (cd), (3) mercury (hg), and (4) controls ... | 1987 | 3295265 |
| [interferon-inducing capability of trypanosoma lewisi]. | | 1973 | 4593361 |
| the relative activities of alanine and aspartate aminotransferases in bloodstream trypanosomes. | | 1973 | 4593642 |
| comparative studies on the persistence of trypanosoma (herpetosoma) musculi and t.(h.) lewisi in immune hosts. | | 1973 | 4593644 |
| physiological and antigenic changes in trypanosoma lewisi mediated by epinephrine. | | 1973 | 4596409 |
| ultrastructure of trypanosoma lewisi, localization and alterations in rat liver. | | 1973 | 4599886 |
| trypanosoma lewisi: stage-specific surface antigens and exoantigens recognized by monoclonal antibodies. | the stage-specific expression of surface antigens by trypanosoma lewisi was investigated using monoclonal antibodies directed against this parasite. hybridomas secreting monoclonal antibodies were produced by the fusion of sp2/0-ag 14 mouse plasmacytomas with spleen cells from rats infected previously with the taliaferro strain of t. lewisi. additivity enzyme-linked immunosorbent assays and indirect immunofluorescent antibody tests indicated the determinant recognized by monoclonal antibody tl40 ... | 1986 | 3514258 |
| trypanosoma lewisi: characteristics of an antigen which induced ablastic antibody. | | 1974 | 4609788 |
| trypanosoma lewisi: ultrastructural changes in rat liver. | | 1974 | 4611080 |
| comparison of the effects of neonatal thymectomy on plasmodium berghei, trypanosoma lewisi and trypanosoma cruzi infection in the albino rat. | | 1974 | 4611081 |
| letter: trypanosomiasis in rats with trichinosis. | | 1974 | 4617351 |
| trypanosoma lewisi: production of exoantigens during infection in the rat. | | 1972 | 4626124 |
| [protection of mice with trypanosoma lewisi antigen and its fractions against experimental trypanosoma cruzi infection]. | | 1972 | 4630386 |
| the occurrence and distribution of alpha-hydroxy-acid dehydrogenase in some members of the order kinetoplastida. | ldh-x is the isoenzyme of lactate dehydrogenase found in mammalian spermatozoa, occurring in cytosolic and mitochondrial locations. gossypol strongly inhibits it, and the spermicidal action of this compound is attributed to the disruption of a reducing shuttle. the flagellated protozoan, trypanosoma cruzi, contains an enzyme activity similar to ldh-x, called alpha-hydroxy-acid dehydrogenase, which is here shown to possess cytosolic and glycosomal components. the glycosome is a microbody-like org ... | 1986 | 3516722 |
| [some data on zooflagellate ribosomes]. | | 1971 | 4942544 |
| the effects of antilymphocytic serum (als) on trypanosoma lewisi infection. | | 1971 | 4943629 |
| trypanosoma lewisi: in vitro behavior of rat spleen cells. | | 1971 | 4944992 |
| studies on the prevelence and effect of trypanosoma lewisi infection in finnish rats. | | 1971 | 4945234 |
| [experimental infection in mastomys natalensis (smith 1834) with trypanosoma species of the lewisi-congolense and brucei-evansi groups]. | | 1971 | 4946451 |
| [protection induced in albino rats by the non-hydrosoluble fraction of trypanosoma lewisi against infection by the homologous strain]. | | 1971 | 4949103 |
| further studies on antigenic changes in trypanosoma lewisi. | | 1968 | 4975999 |
| [trypanosoma cruzi infection in mice following their sensitization with trypanosoma lewisi]. | | 1969 | 4976979 |
| [analysis and preparation of antigens from trypanosoma lewisi]. | | 1969 | 4987192 |
| [reaction of the mouse to serotherapy and infection with trypanosoma lewisi]. | | 1971 | 5002625 |
| the effect of the immunosuppressive agent cyclophosphamide on igg levels and parasite number in experimental trypanosomiasis. | | 1971 | 5003594 |
| trypanosoma lewisi in liquid culture: findings and comparisons with different types of media. culture medium for trypanosoma lewisi. | the culture technique used proved to be more simple and economical than the different culture methods described in literature. this process permits the in vitro growth of parasites for a period long enough (10 days) to determine the possible activity of drugs. on the 10th day the cultures are infectious. | 1986 | 3521672 |
| a surface glycoprotein of trypanosoma lewisi binds immunoglobulin g from the serum of uninfected rats. | detergent extracts of whole trypanosoma lewisi were fractionated by polyacrylamide gel electrophoresis and transferred to nitrocellulose for immunoblotting analysis. antibody probes to rat immunoglobulin g (igg) and igm detected intact gamma chains, mu chains, and light chains in extracts. the amount of immunoglobulin detected increased as the infection progressed. transfers were also incubated in serum from conventionally reared (crs), specific-pathogen-free (spfs), or germ-free rats before bei ... | 1986 | 3525414 |
| cultivation of trypanosoma lewisi in a dialysate medium. i. amino acid alterations during growth. | | 1969 | 5347604 |
| intracellular stages of trypanosoma lewisi in fleas and attempts to find such stages in other trypanosome species. | | 1969 | 5357319 |
| intracellular stages of trypanosoma lewisi in fleas and attempts to find such stages in other trypanosome species. | | 1969 | 5374709 |
| flow cytometric analysis of immunoglobulin and complement component c3 on the surface of trypanosoma lewisi. | we have reinvestigated whether surface immunoglobulin (sig) on trypanosoma lewisi is antibody directed toward parasite antigen by using flow cytometry to analyze parasites stained with fluoresceinated f(ab')2 fragments of antibodies to rat igg and igm. we have confirmed that igg antibody to the parasites is present both in the serum of rats and on the surface of parasites between the fourth and twentieth days of infection, that the amount of sig per cell increases as the infection progresses, an ... | 1986 | 3525820 |
| elicitation of the reproduction-inhibiting antibody ablastin by serum exoantigens of trypanosoma lewisi. | serum exoantigens of trypanosoma lewisi were collected 5 days after infection from immunocompetent (untreated) rats and rats immunosuppressed by treatment with either hydrocortisone acetate or dexamethasone. normal rats were then immunized with pooled, whole exoantigen-containing serum from 1 of these 3 sources plus alum as an adjuvant, and the immune sera produced were tested individually. all contained agglutinating (trypanocidal) antibodies to both antigenic variants of t. lewisi, but only ab ... | 1986 | 3546658 |
| isoenzyme characterization of trypanosomes of the subgenus herpetosoma. | isoenzyme analysis was used to characterize 6 species of trypanosomes of the subgenus herpetosoma using 13 different enzyme systems. the species studied were trypanosoma lewisi, t. musculi, t. grosi, t. microti, t. evotomys and t. nabiasi which cannot be distinguished on morphological grounds. extracts for thin-layer starch-gel electrophoresis were prepared from cultures of insect forms in either schneider's drosophila or grace's insect tissue culture media with foetal calf serum or a nutrient a ... | 1987 | 3547258 |
| the specific anti-parasite immune responses of germ-free and conventional rats infected with trypanosoma lewisi. | to test the hypothesis that the rapid immune response of rats to trypanosoma lewisi is elicited by prior exposure to cross-reacting environmental antigens, the early immune response to infection with this nonpathogenic protozoan was studied in germ-free and conventional rats. in germ-free rats, initial levels of both igg and igm were significantly lower than those of conventional rats. after infection, the germ-free rats made more immunoglobulins of both classes, and made them more quickly, than ... | 1987 | 3553515 |
| trypanosoma lewisi: restriction of alternative complement pathway c3/c5 convertase activity. | the rat parasite trypanosoma lewisi was incubated in vitro with rat or human serum, washed, and extracted in detergent. extracts were fractionated by electrophoresis in denaturing gels, transferred to nitrocellulose, allowed to renature, then immunoblotted with polyclonal antibodies to rat complement component c3 and human complement components c3, c5, and factor b. molecules that reacted with these antibodies were detected in the extracts. fragments of rat c3 were detected in extracts of parasi ... | 1987 | 3556206 |
| interaction of nutrition and infection: effect of vitamin b12 deficiency on resistance to trypanosoma lewisi. | a metabolic imbalance technique was employed to study vitamin b(12) deficiency in rats infected with trypanosoma lewisi. throughout the observational period, animals on the deficient diet had lowered serum vitamin b(12) levels compared with complete and pair-fed animals. the decline in the level of the vitamin, ten days after the initiation of the experiment, continued progressively until the termination of the study. body weight gains and food consumption in rats on complete, vitamin b(12)-defi ... | 1985 | 3889354 |
| effect of some antibiotics and chemotherapeutics on trypanosoma lewisi infection in albino rats. | | 1985 | 3902989 |
| trypanolytic activity, agglutinins, and opsonins in sera from animals refractory to trypanosoma lewisi. | an examination of sera from a range of animals refractory to trypanosoma lewisi showed that some contain trypanolytic activity and agglutinins for this trypanosome. trypanolytic activity was demonstrated in bovine, sheep, and rabbit serum. these sera were shown to also contain agglutinins. the trypanolytic activity in all three sera was abolished by heat inactivation at 56 degrees c for 30 min. studies with bovine serum showed that the lytic activity was totally inhibited by the addition of edta ... | 1985 | 3926649 |
| monoclonal antibodies to metacyclic stage antigens of trypanosoma cruzi. | hybridoma cell lines secreting monoclonal antibodies against the tulahuén strain of trypanosoma cruzi were produced by the fusion of sp2/o-ag 14 myeloma cells with spleen cells from mice immunized with irradiated metacyclic trypomastigotes. twenty of the monoclonals synthesized by the hybridomas were identified as igm, 2 as igg1, 10 as igg2a, 3 as igg2b, 4 as igg3, 1 as ige, and 1 as iga. twenty-three of these antibodies had kappa light chains and 18 showed delta chains. twelve of the monoclonal ... | 1985 | 3927760 |
| the lipid metabolism of blood and culture forms of trypanosoma lewisi and trypanosoma rhodesiense. | | 1971 | 4330390 |
| the effects of pantothenic acid, pantoyltaurine, salicylate and related compounds on the in vitro and in vivo growth of trypanosoma lewisi. | | 1968 | 5710274 |
| [behavior of the blood mucoproteins in rats infected with trypanosoma lewisi]. | | 1968 | 5715925 |
| some aspects of aminotransferases of trypanosomes. | | 1972 | 4558830 |
| trypanosome sterols and their metabolic origins. | | 1972 | 4561635 |
| comparison of mitochondrial enzymes between young and adult forms of trypanosoma lewisi. | | 1968 | 5719060 |
| electron microscope investigations of the structure of some specimens of the trypanosomidae family in connection with their ability to occur in the dyskinetoplastic state. 1. trypanosoma. | | 1972 | 4563776 |
| interaction of nutrition and infection: macrophage activity in vitamin b12-deficient rats infected with trypanosoma lewisi. | macrophage activity was studied in rats infected with trypanosoma lewisi in three protocol groups: one group was fed complete diet, a second group was given a vitamin b(12)-deficient diet, and a third group was fed a pair-fed control (calorically restricted) diet. throughout the observational period, in animals fed complete and pairfed diets, marked increases in acid phosphatase levels in peritoneal macrophages were directly related to the degree of parasitemia. acid phosphatase levels in rats d ... | 1987 | 3295263 |
| carbohydrate transport in trypanosoma lewisi. | | 1969 | 5778271 |
| comparative studies on blood stream and culture forms of trypanosoma lewisi. i. oxygen utilization, carbon dioxide production and glucose uptake. | | 1969 | 5788607 |
| species-characteristic isoenzymes of two aminotransferases in trypanosomes. | | 1973 | 4578888 |
| [fractional makeup of the lipids in cultures of trypanosoma lewisi i trypanosoma cruzi]. | | 1972 | 4580549 |
| comparative immunological studies on somatic antigens and secretion-excretion products of blood stream and culture forms of trypanosoma lewisi. i. protective immunity and the agglutinin response. | | 1969 | 5795103 |
| [identification of a laboratory strain hitherto believed to be trypanosoma lewisi (author's transl)]. | | 1973 | 4582780 |
| serum transaminases and aldolase in rats inoculated with trypanosoma lewisi. | | 1966 | 5933980 |
| oxygen uptake by trypanosoma lewisi-complex cells. ii. r and l isolates compared. | | 1966 | 5940094 |
| a trypanosoma lewisi-like organism from the rabbit, sylvilagus floridanus, in virginia. | | 1966 | 5942537 |
| oxygen uptake by trypanosoma lewisi complex cells. 3. c isolate. | | 1966 | 5943918 |
| trypanosoma lewisi: electron microscopy of the infected spleen. | | 1973 | 4583054 |
| phospholipids of trypanosoma lewisi, t. vivax, t. congolense, and t. brucei. | | 1967 | 6026221 |
| host serum malic dehydrogenase activity associated with trypanosoma lewisi infection. | | 1967 | 6027419 |
| trypanosome identification by electrophoresis of soluble enzymes. | | 1973 | 4583509 |
| isoenzymic differences between culture forms of trypanosoma rangeli, t. cruzi, and t. lewisi. | | 1974 | 4608715 |
| correlation of oligomycin-sensitive atpase activity in trypanosomes with their content of an antigen to primary biliary cirrhosis. | the amounts of an antigen to primary biliary cirrhosis (pbc) which occur in subcellular fractions of trypanosoma rhodesiense and t. lewisi correlate positively with the oligomycin-sensitive (os) atpase activity of these fractions. this result is consistent with the mitochondrial atpase association of the antigen in mammalian and other cells. higher levels of os-atpase and of pbc antigen in t. lewisi accord with a more extensive mitochondrial development in this species. | 1984 | 6239698 |
| molecular cloning of the "minor" component of the kinetoplast dna of trypanosoma lewisi. | kinetoplast dna was cloned in the pbr322 plasmid using the bamhi site. in situ hybridization of iodinated recombinant dna showed hybridization grains only in the kinetoplast region. the recombinant dna was analyzed with restriction enzymes and its base ratio was determined by analytical cscl density gradient. | 1980 | 6257401 |
| carnitine acetyltransferase activity in trypanosoma lewisi. | | 1971 | 4941537 |
| basis of the specificity of rodent trypanosomes for their natural hosts. | the strong natural insusceptibility of mice to infection with the rat-specific trypanosoma lewisi was investigated in a variety of mouse strains. parasite elimination by all strains was similar involving a lag phase of about 7 h of constant parasitemia followed by rapid clearance (half-times of 55 and 130 min in different strains). in vitro cultures were utilized to determine whether mouse cells and serum were inherently deficient in supporting t. lewisi or, alternatively, toxic for the parasite ... | 1981 | 6268542 |
| [comparative studies of the desoxythymidylate synthesis in plasmodium chabaudi, trypanosoma gambiense and trypanosoma lewisi]. | | 1970 | 5275559 |
| trypanosoma lewisi infection in the rat: effect of adenine. | the reproductive activity of trypanosoma lewisi was strikingly enhanced and sometimes prolonged for 2 days when sublethal doses of adenine were given to rats. the drug was effective when given for 5 or 7 days in the diet and/or intraperitoneally, starting one or two days before infection through two days after infection. peak parasitemia was also enhanced. in terms of host immunity, daily sublethal doses of adenine given to rats within two days before or after infection with t. lewisi significan ... | 1971 | 5276290 |
| the effect of splenectomy on the production of ablastin and the termination of the parasitaemia in rats infected with trypanosoma lewisi. | this study investigated the effect of splenectomy on the production of ablastin and the elimination of trypanosoma lewisi from the circulation of infected porton rats. rats were splenectomized or sham-splenectomized either before or at various stages during the infection and the course of the parasitaemia compared with untreated control animals. ablastin titres in the serum were measured by a sensitive in vitro assay and were found to be the same in all the rats, regardless of the nature or timi ... | 1983 | 6349598 |
| comparative studies on blood-stream and culture forms of trypanosoma lewisi. ii. biochemical composition. | | 1970 | 5435731 |
| the lipid composition of blood and culture forms of trypanosoma lewisi and trypanosoma rhodesiense compared with that of their environment. | | 1970 | 5440923 |
| effect of holothurin on trypanosoma lewisi infections in rats. | | 1970 | 5449233 |
| externally disposed membrane polypeptides of intact and protease-treated trypanosoma lewisi correlated with sensitivity to alternate complement pathway-mediated lysis. | reproducing forms of trypanosoma lewisi isolated from x-irradiated rats and adult forms from intact rats were not lysed by fresh mammalian sera. treating parasites with trypsin or chymotrypsin, but not with neuraminidase, under conditions which did not impair viability rendered the parasites sensitive to lysis by rat, mouse, rabbit, and human sera. serum from animal strains or humans genetically deficient in complement component c3, c5, or c6 did not lyse protease-treated parasites. the lytic fa ... | 1983 | 6358042 |
| kinetoplast deoxyribonucleic acid of the hemoflagellate trypanosoma lewisi. | cesium chloride centrifugation of dna extracted from cells of blood strain trypanosoma lewisi revealed a main band, rho = 1.707, a light satellite, rho = 1.699, and a heavy satellite, rho = 1.721. culture strain t. lewisi dna comprised only a main band, rho = 1.711, and a light satellite, rho = 1.699. dna isolated from dnase-treated kinetoplast fractions of both the blood and culture strains consisted of only the light satellite dna. electron microscope examination of rotary shadowed preparation ... | 1970 | 5497546 |
| trypanosoma lewisi: physiologic adaptation of wild isolate to albino rats evidenced by cell populations and respiratory activity. | | 1971 | 5556286 |
| trypanosoma lewisi infections in normal rats and in rats treated with dexamethasone. | | 1968 | 5643477 |
| fine structure and replication of the kinetoplast of trypanosoma lewisi. | the kinetoplastic dna of trypanosoma lewisi is described as a filamentous body lying within a mitochondrion, with the filaments oriented parallel to the long axis of the cell. the manner of fixation, the replicative state, and perhaps the physiological state of the cell, may result in slight morphological differences among such bodies. the kinetoplastic dna replicates to form "left" and "right" rather than "upper" and "lower" members, and both the kinetoplast and nucleus incorporate radiothymidi ... | 1968 | 5677967 |
| trypanosoma lewisi: the effect of thymectomy on the production of ablastin and the termination of the parasitaemia in infected rats. | this study investigated the effect of the depletion of t lymphocytes on the production of ablastin and the termination of the parasitaemias in porton strain rats infected with trypanosoma lewisi. weanling rats were thymectomised or sham-thymectomised and then x-irradiated. after allowing 96 days for recovery from these procedures the rats were infected with t. lewisi. the rats were considered to be t lymphocyte depleted if they were unable to mount an antibody response to sheep red blood cells b ... | 1984 | 6388547 |
| mechanical transmission of trypanosoma lewisi (kinetoplastida: trypanosomidae) by rhodnius prolixus (hemiptera: reduviidae). | | 1968 | 5699976 |
| redescription of the life cycle of trypanosoma (herpetosoma) lewisi from upper egyptian rats. | | 1984 | 6392437 |
| growth and immunologic studies on the culture forms of trypanosoma lewisi. | | 1968 | 5703435 |
| [studies on the experimental infection with trypanosoma lewisi in mice]. | | 1968 | 5707633 |
| [behavior of serum copper in rats during experimental infection with trypanosoma lewisi]. | | 1968 | 5715931 |
| [a new finding on trypanosoma (herpetosoma) forattinii coutinho et pattoli 1964 in the state of são paulo, brazil]. | | 1982 | 6753050 |
| [behavior of iron in the blood in experimental infection with trypanosoma lewisi]. | | 1968 | 5715932 |
| a semi-automated microassay method for the measurement of ablastin, a division inhibitory antibody. | division of trypanosoma lewisi in the rat is terminated by ablastin, a factor(s) in the serum of rats acquired during infection which is believed to be specific antibody. in this study a semi-automated microassay technique for the measurement of ablastin is described. the system involved the use of [3h]tdr as a marker for trypanosome division and a multiple-well cell harvester to harvest trypanosomes from wells of microtitre plates. the method is versatile, quantitative and easy to perform, perm ... | 1982 | 6759583 |
| [on the host specificity of trypanosoma lewisi infection]. | | 1968 | 5719578 |