| botulinum toxin antibody testing: comparison between the mouse protection assay and the mouse lethality assay. | conventionally, the standard test for detection of antibodies against botulinum toxin (bt-a) has been the mouse lethality assay (mla). because this test has a number of disadvantages, a novel mouse protection assay (mpa) was recently introduced. we sought to compare the results of both tests. forty-three samples from 38 patients with cervical dystonia and complete or partial subjective bt-a therapy failure underwent simultaneous mpa and mla testing. twenty-seven samples showed concordant results ... | 2000 | 11009207 |
| calcium and digoxin vs. calcium alone for severe verapamil toxicity. | calcium chloride (cacl(2)) is ineffective in severe calcium channel antagonist overdoses. digoxin increases intracellular calcium by inhibiting the sodium-potassium adenosine triphosphatase enzymes. | 2000 | 11015239 |
| analysis of 42 cases of septicemia caused by an epidemic strain of methicillin-resistant staphylococcus aureus: evidence of resistance to vancomycin. | recent case reports of vancomycin treatment failures in the united states, japan, and france have prompted a retrospective analysis of 42 cases of septicemia caused by epidemic methicillin-resistant staphylococcus aureus strain 15 (emrsa-15), which is the most prevalent epidemic strain of methicillin-resistant s. aureus in the united kingdom; all cases occurred in a teaching hospital in manchester, united kingdom, between 1994 and 1998. mortality was lowest (4%) in patients with rifampin-suscept ... | 2000 | 11017816 |
| inositol (1,4,5)trisphosphate metabolism and enhanced calcium mobilization in airway smooth muscle of hyperresponsive rats. | airway hyperresponsiveness (ahr) is a phenotype of asthma and can be modeled by the inbred fisher strain of rat, which is hyperresponsive in vivo relative to the lewis strain. enhanced airway smooth muscle (asm) contractility and ca(2+) mobilization are associated with the ahr observed in fisher rats. in this study, we investigated whether the interstrain differences in ca(2+) mobilization to serotonin (5ht) result from differences in inositol (1,4,5)trisphosphate (ip(3)) metabolism and/or ip(3) ... | 2000 | 11017917 |
| inhibitory effect of cystic fibrosis sputum on adenovirus-mediated gene transfer in cultured epithelial cells. | effective gene transfer to the airway epithelial cells of individuals with cystic fibrosis (cf) requires gene therapy vectors to effectively penetrate the mucous lining of the airways of these patients. in this study, we examined the effects of the aqueous sol fraction of sputum recovered from cf patients (cf sol) on adenovirus (ad)-mediated gene transfer to cultured epithelial cells. sputum collected from patients with cf was separated into aqueous sol and gel fractions by ultracentrifugation a ... | 2000 | 11020799 |
| treatment with a combined endothelin a/b-receptor antagonist does not prevent chronic renal allograft rejection in rats. | a markedly increased expression of endothelin (et)-1 has been observed in renal allografts with chronic rejection, one of the most common causes of kidney graft loss. in this study we investigated the effect of treatment with a combined et-a/b-receptor antagonist on the course of chronic renal allograft rejection. experiments were performed in the fisher-to-lewis rat model of chronic rejection. lewis-to-lewis isografts and uninephrectomized lewis rats served as controls. animals were treated wit ... | 2000 | 11026642 |
| fish 3: a microworld for studying social dilemmas and resource management. | a java-based microworld environment for studying resource management is described. fish 3 may be used in research or the classroom to investigate commons dilemmas and resource dilemmas. the program uses ocean fishing as its metaphor; participants ("fishers") experience the metaphor through both graphics ("fish" may be seen in an ocean) and text (e.g., resource replenishment is translated as "spawning"). in either stand-alone or networked modes, either with all human fishers or a mixture of human ... | 2000 | 11029814 |
| preparation and preclinical evaluation of a novel liposomal complete-core lipopolysaccharide vaccine. | our objective is to develop a prophylactic vaccine strategy that can be evaluated for surgical and other high-risk hospitalized patients. in this paper, we describe the preparation and preclinical evaluation of a liposomal complete-core lipopolysaccharide (lps) vaccine that is nontoxic and broadly antigenic. complete-core (ra-chemotype) lpss were isolated from four gram-negative bacterial strains (escherichia coli k-12, e. coli r1, pseudomonas aeruginosa pac608, and bacteroides fragilis), mixed ... | 2000 | 11035726 |
| a defect of lipopolysaccharide-induced nitric oxide synthase gene expression in the paraventricular nucleus of lewis rats. | the hypothalamo-pituitary-adrenal (hpa) axis activity of lewis rats has been reported to be hyporesponsive to immune challenge, and nitric oxide (no) has been demonstrated to be involved in the regulation of the hpa axis during the response to immune challenge. the present study investigates the effect of systemic injection of lipopolysaccharide (lps) on no production within the paraventricular nucleus (pvn) of immature female fisher-344 (f344) and lew/n rats (lew/n), to clarify the pathophysiol ... | 2000 | 11036864 |
| quantitative genetic analysis of circulating levels of biochemical markers of bone formation. | carboxyterminal propeptide of type 1 collagen (picp) and bone gla-protein-osteocalcin (bgp) are the most important components of the organic bone matrix and play a key role in bone formation. to investigate whether and to what extent variation of the plasma levels of these indices of bone turnover depends on genetic factors, we studied 355 adults belonging to nuclear pedigrees. genetic analysis was carried out in 2 steps: 1) variance decomposition analysis was performed using the fisher statisti ... | 2000 | 11038447 |
| region-specific decline in the expression of metabotropic glutamate receptor 7 mrna in rat brain during aging. | age-dependent changes in the expression of group iii metabotropic glutamate receptors (mglur4 and mglur7) were studied by quantitative in situ hybridization using male fisher 344 rats 3, 12 and 25 months of age. results indicate an early decrease in mglur7 mrna level in several cortical areas including the frontal, parietal and temporal cortices. in the hippocampus, mglur7 mrna levels decreased in the ca1 region and the lower blade of the dentate gyrus. moreover, significant decrease was found i ... | 2000 | 11042362 |
| human leukocyte antigen class ii alleles in white brazilian patients with celiac disease. | celiac disease (cd) is a permanent gluten intolerance disorder characterized by malabsorption, intestinal mucosa villus atrophy, and crypt hyperplasia. clinical and histologic features improve in persons consuming a gluten free diet. the pathogenesis of cd involves environmental, genetic, and immunologic factors. | 2000 | 11045836 |
| plasminogen activation in experimental permanent focal cerebral ischemia. | previous experimental work using in situ zymography has shown very early increased plasminogen activation in ischemic regions after 3 h of ischemia with and without reperfusion. the objective of the present study was to evaluate the time course and extent of plasminogen activation in long-term permanent focal cerebral ischemia. | 2000 | 11056180 |
| radiosynthesis of [18f]lu29-024: a potential pet ligand for brain imaging of the serotonergic 5-ht2 receptor. | in a previous work, lu29-024 (2,5-dimethyl-3-(4-fluorophenyl)-1-(1-methyl-4-piperidinyl)-1h-indole), a selective 5-ht2a receptor antagonist with nanomolar affinity and high selectivity, was labeled with carbon-11 to evaluate its behavior as a potential pet ligand for the serotonergic 5-ht2a receptor in the central nervous system. administration of this tracer to rats was followed by a good brain uptake, no brain labeled metabolites but no specific, regio-selective, binding at 20 and 40 min post ... | 2000 | 11058046 |
| decreased expression of nitric oxide synthase in the colonic myenteric plexus of aged rats. | nitric oxide (no) is a major non-adrenergic, non-cholinergic (nanc) inhibitory neurotransmitter in the gastrointestinal tract. no released from the myenteric plexus enhances colonic transit and facilitates propulsion of the colonic contents by mediating descending relaxation. although it has been suggested that colonic transit delays with aging, the mechanism of delayed colonic transit in aging remains unclear. we hypothesized that advanced age is associated with decreased expression of neuronal ... | 2000 | 11063983 |
| activation of the heart by donor brain death accelerates acute rejection after transplantation. | donor brain death upregulates expression of inflammatory mediators in the heart. it is hypothesized that these nonspecific changes trigger and amplify acute rejection in unmodified recipients compared with hearts from normal living donors. we examined the inflammatory and immunological consequences of gradual-onset donor brain death on cardiac allografts after transplantation. | 2000 | 11067799 |
| new approach in the therapy of chronic rejection? ace- and at1-blocker reduce the development of chronic rejection after cardiac transplantation in a rat model. | angiotensin ii is one of the most potent mitogens of smooth muscle cell proliferation and plays a central role in the development of accelerated coronary artery disease (acad), which remains a serious consequence after heart transplantation and limits long-term survival. we investigated the effect of an angiotensin-ii blocker, losartan (angiotensin ii type 1 [at(1)]-blocker), and an angiotensin-converting enzyme (ace) inhibitor, enalapril, on experimental acad in a rat cardiac transplant model ( ... | 2000 | 11077221 |
| quantitation of hsv mass distribution in a rodent brain tumor model. | a number of different viral vectors have been used for gene therapy of tumors, with many more under construction, ultimately designed to improve tumor targeting and transduction efficiency. it has become apparent that insufficient viral delivery can be a key limitation to treatment efficacy. we have studied the in vivo mass distribution of a herpes simplex virus type 1 (hsv) vector, hrr3, by radiolabeling it with 111in-oxine. the virus was administered to intracerebral 9l glioma bearing fisher ( ... | 2000 | 11083473 |
| coadministration of the new macrolide immunosuppressant rad and mycophenolate mofetil in experimental corneal transplantation. | the effect of rad, a new macrolide immunosuppressant, was examined as mono- and combination therapy with mycophenolate mofetil (mmf) in prevention of acute allograft rejection in murine corneal transplantation. | 2000 | 11087159 |
| activation of sphingolipid turnover and chronic generation of ceramide and sphingosine in liver during aging. | aging leads to a decreased ability of liver to metabolize drugs and increased expression and secretion of acute phase proteins, such as serum amyloid a (saa), c-reactive protein (crp), and alpha-1-acid glycoprotein (agp). this phenomenon resembles some aspects of the acute phase response of host to inflammation; however, the molecular basis for the similarity is unclear. ceramide and sphingosine are second messenger mediators of cellular responses to stress and inflammation. in liver, they play ... | 2000 | 11087909 |
| relationship between the concentration of cddp in tumor and tumor size after isolated lung perfusion treatment experimental study on a solitary pulmonary sarcoma model in rats. | few investigations on the pharmacokinetics of isolated lung perfusion (ilp) regional chemotherapy in tumors have been conducted. the purpose of this study was to evaluate the pharmacokinetic character of ilp in tumor tissues. materials and methods a solitary tumor nodule model was established in fisher 344 rats by inoculating 1.0 x 10(6) methylcholanthrene-induced sarcoma cells into the left lung. on 14-21 days after the inoculation of tumor cells, rats were randomized into groups subjected to 1 ... | 2000 | 11088051 |
| transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: effects of different cytotoxins on cytochrome p450 isoforms expression and on glycogen content. | syngenic fetal liver tissue suspensions were transplanted into the spleens of adult male fisher 344 inbred rats. four months after surgery, transplant recipients and age matched control rats were treated with different cytotoxins (allyl alcohol [aal], bromobenzene [bbz], carbon tetrachloride [ccl4], or thioacetamide [taa]) or the respective solvents 24 or 48 hours before sacrifice. effects of the cytotoxins on the expression of three cytochrome p450 (p450) isoforms, 1a1, 2b1 and 3a2, within sple ... | 2000 | 11089889 |
| tracheal constrictor drive above the apneic threshold in anesthetized dogs. | we have previously shown that raising arterial pco(2) (pa(co(2))) by small increments in dogs ventilated below the apneic threshold (at) results in almost complete tracheal constriction before the return of phrenic activity (dickstein ja, greenberg a, kruger j, robicsek a, silverman j, sommer l, sommer d, volgyesi g, iscoe s, and fisher ja. j appl physiol 81: 1844-1849, 1996). we hypothesized that, if increasing chemical drive above the at mediates increasing constrictor drive to tracheal smooth ... | 2000 | 11090576 |
| expression and prognostic significance of survivin in de novo acute myeloid leukaemia. | survivin is an inhibitor of apoptosis (programmed cell death) overexpressed in various human cancers, but undetectable in normal differentiated tissues. a potential distribution and prognostic significance of survivin in patients with de novo acute myeloid leukaemia (aml) was investigated. by immunofluorescence of bone marrow specimens and peripheral blood mononuclear cells, survivin was detected in 75 out of 125 interpretable aml cases (60%), with reactivity in 50-90% of aml cells. survivin exp ... | 2000 | 11091201 |
| chemoprevention with theaflavins of rat esophageal intraepithelial neoplasia quantitatively monitored by image tile analysis. | the objective of the study was to compare three methods of monitoring the inhibition by dietary theaflavins of n-nitrosomethylbenzylamine (nmba)-induced rat esophageal intraepithelial neoplasia: the mean tile grade, measured by computer-assisted quantitative image tile analysis; tumor multiplicity; and mean tumor size. a "tile" is defined as a small portion of a microscopic image at x 40, 87 x 292 microm in size. the computer divided the image of esophageal intraepithelial neoplasia into a grid ... | 2000 | 11097221 |
| the role of human and mouse y chromosome genes in male infertility. | it was suggested by ronald fisher in 1931 that genes involved in benefit to the male (including spermatogenesis genes) would accumulate on the y chromosome. the analysis of mouse y chromosome deletions and the discovery of microdeletions of the human y chromosome associated with diverse defective spermatogenic phenotypes has revealed the presence of intervals containing one or more genes controlling male germ cell differentiation. these intervals have been mapped, cloned and examined in detail f ... | 2000 | 11097427 |
| adenovirus-mediated hepatocyte growth factor gene transfer prevents lethal liver failure in rats. | hepatocyte growth factor (hgf) has a potent antiapoptotic effect on hepatocytes in d-galactosamine (d-galn)/lipopolysaccharide (lps)-treated rats. here, we report that adenovirus mediated hgf gene transfer into liver prevents liver failure and reduces mortality of rats treated with d-galn/lps. fisher 344 rats, which were given intraperitoneal injections of paxcahgf 48 h before, were treated with d-galn/lps. serum alt in the hgf group at 6 and 12 h after d-galn/lps was decreased to 1/6 and 1/12 o ... | 2000 | 11097840 |
| calcium and growth responses of hyperresponsive airway smooth muscle to different isoforms of platelet-derived growth factor (pdgf). | airway smooth muscle (asm) mass is likely to be an important determinant of airway responsiveness. highly inbred fisher rats model innate hyperresponsiveness, and also have more asm in vivo than control lewis rats. platelet derived growth factor (pdgf) is an important endogenous growth factor for asm, and partially purified pdgf-ab causes enhanced growth of fisher rat asm cells, compared to lewis cells. the aim of the present study was to determine the mitogenic effects of all three recombinant ... | 2000 | 11100934 |
| serotonergic modulation of ethanol-induced electrophysiological depression in young and aged rats. | ethanol (etoh)-induced electrophysiological depressions in cerebellar purkinje neurons have been shown to be potentiated by exogenously applied serotonin (5ht). in this study, we determined whether this modulatory action can be activated by endogenous release from presynaptic serotonergic terminals, and whether such a response is altered by age or rat strain. | 2000 | 11104121 |
| evidence for two distinct effector-binding sites in threonine deaminase by site-directed mutagenesis, kinetic, and binding experiments. | a three-dimensional structure comparison between the dimeric regulatory serine-binding domain of escherichia coli d-3-phosphoglycerate dehydrogenase [schuller, d. j., grant, g. a., and banaszak, l. j. (1995) nat. struct. biol. 2, 69-76] and the regulatory domain of e. coli threonine deaminase [gallagher, d. t., gilliland, g. l., xiao, g., zondlo, j., fisher, k. e., chinchilla, d. , and eisenstein, e. (1998) structure 6, 465-475] led us to make the hypothesis that threonine deaminase could have t ... | 2000 | 11106492 |
| carl düsing (1884) on the regulation of the sex-ratio. | in three publications in 1883 and 1884 carl düsing of jena gave a mathematical account of the influence of natural selection on the sex ratio based on the same argument that darwin had advanced in the descent of man (1871). the argument thus became quite well known, being included in the principal books on the subject around the turn of the century, as well as in the encyclopaedia britannica, references to düsing being given. by 1930, when fisher gave a verbal account of the argument in the gene ... | 2000 | 11120652 |
| current cases in which epitope mimicry is considered a component cause of autoimmune disease: guillain-barré syndrome. | some patients develop guillain-barré syndrome (gbs) after the administration of bovine gangliosides. patients with gbs subsequent to campylobacter jejuni enteritis frequently have igg antibody to gm1 ganglioside. miller fisher syndrome (mfs), a variant of gbs, is associated with igg antibody to gq1b ganglioside. molecular mimicry between gm1 and lipopolysaccharide of c. jejuni isolated from patients with gbs, and between gq1b and c. jejuni lipopolysaccharides from patients with mfs have been dem ... | 2000 | 11130452 |
| kinetic model of in vivo folding and inclusion body formation in recombinant escherichia coli. | aggregation of misfolded proteins can reduce the yield in recombinant protein production. the underlying complex processes are additionally influenced by cellular physiology. nevertheless, a lumped-parameter model of kinetic competition between folding and aggregation was sufficient to track properly the specific concentration of a human protein produced in e. coli and its partitioning into soluble and insoluble cell fractions. accurate estimation of the protein-specific parameters required info ... | 2001 | 11135201 |
| treatment of aged rat sensory neurons in short-term, serum-free culture with nerve growth factor reverses the effect of aging on neurite outgrowth, calcium currents, and neuronal survival. | impaired ngf production and release has been documented in aged animals, suggesting that decreased ngf receptor stimulation may be one factor contributing to neuronal dysfunction with aging. other studies have suggested that aging may be associated with impaired intracellular responses to ngf. because aging-associated neuronal dysfunction contributes to morbidity and mortality in the geriatric population, it is important to determine whether the effects of aging on sensory neuron function and su ... | 2001 | 11146059 |
| combined pre- and postsynaptic action of igg antibodies in miller fisher syndrome. | miller fisher syndrome (mfs), a variant of the guillain-barré syndrome, is associated with the presence of neuromuscular blocking antibodies, some of which may be directed at the ganglioside gq1b. | 2001 | 11148238 |
| acute ophthalmoparesis (without ataxia) associated with anti-gq1b igg antibody: clinical features. | to examine the clinical features of acute ophthalmoparesis (ao) (without ataxia) associated with anti-gq1b immunoglobulin g (igg) antibody. | 2001 | 11150289 |
| the effects of 10 days of spaceflight on the shuttle endeavor on predominantly fast-twitch muscles in the rat. | the primary purpose of this investigation was to determine the effects of microgravity on muscle fibers of the predominantly fast-twitch muscles in the rat. cross sectional area and myosin heavy chain (mhc) composition were assessed in order to establish the acute effects of microgravity associated with spaceflight. the extensor digitorum longus (edl) and gastrocnemius muscles were removed from 12 male fisher 344 rats which had undergone 10 days of spaceflight aboard the space shuttle endeavor a ... | 2000 | 11151404 |
| risk and prognostic factors of postherpetic neuralgia and focal sensory denervation: a prospective evaluation in acute herpes zoster ophthalmicus. | to determine the general risk and the prognostic factors of postherpetic neuralgia and focal sensory denervation in ophthalmic zoster disease. | 2000 | 11153792 |
| global patterns of human dna sequence variation in a 10-kb region on chromosome 1. | human dna variation is currently a subject of intense research because of its importance for studying human origins, evolution, and demographic history and for association studies of complex diseases. a approximately 10-kb region on chromosome 1, which contains only four small exons (each <155 bp), was sequenced for 61 humans (20 africans, 20 asians, and 21 europeans) and for 1 chimpanzee, 1 gorilla, and 1 orangutan. we found 52 polymorphic sites among the 122 human sequences and 382 variant sit ... | 2001 | 11158380 |
| nuclear receptor car as a regulatory factor for the sexually dimorphic induction of cyb2b1 gene by phenobarbital in rat livers. | the nuclear receptor constitutive active receptor (car) translocates into liver nuclei after phenobarbital (pb) treatment, and activates the conserved enhancer called the pb-response element module (pbrem) found in cyp2b genes. we have examined whether car regulates the dimorphic induction by pb of the cyp2b1 gene in wistar kyoto (wky) rats. northern blot analysis showed that pb induced cyp2b1 mrna in male wky rats but not female rats. an in situ injected pbrem-luciferase reporter gene was activ ... | 2001 | 11160864 |
| deficits in the expression of the nr2b subunit in the hippocampus of aged fisher 344 rats. | the nmda receptor (nmdar) has been implicated in the induction of ltp at hippocampal synapses, and has been proposed to play a significant role in the involvement of the hippocampus with learning and memory. aged rats are known to have deficits in ltp, learning and memory. we tested the hypothesis that aged rats might have deficits in expression of nmdar subunits. aged rats have significantly lower levels of nr2b mrna and protein compared to young animals. this complements a recent report which ... | 2001 | 11164294 |
| correlation of intact sensibility and neuropathic pain-related behaviors in eight inbred and outbred rat strains and selection lines. | in some rat strains, total hindpaw denervation triggers autotomy, a behavior of self mutilation presumably related to neuropathic pain. partial sciatic ligation (psl) in rats produces tactile allodynia and heat hyperalgesia but not autotomy. our aims in this study were to examine: (1) whether sensibility of intact rats to noxious and non-noxious stimuli is strain-dependent; (2) whether sensibility of intact rats could predict levels of autotomy, or of allodynia and hyperalgesia in the psl model; ... | 2001 | 11166972 |
| transition state complexes of the klebsiella pneumoniae nitrogenase proteins. spectroscopic properties of aluminium fluoride-stabilized and beryllium fluoride-stabilized mgadp complexes reveal conformational differences of the fe protein. | stable inactive 2 : 1 complexes of the klebsiella pneumoniae nitrogenase components (kp2/kp1) were prepared with adp or the fluorescent adp analogue, 2'(3')-o-[n-methylanthraniloyl] adp and alf(4)(-) or bef(3)(-) ions. by analogy with published crystallographic data [schindelin et al. (1997) nature 387, 370-376)], we suggest that the metal fluoride ions replaced phosphate at the two atp-binding sites of the iron protein, kp2. the beryllium (bef(x)) and aluminium (alf(4)(-)) containing complexes ... | 2001 | 11168422 |
| a controlled trial of topical nitroglycerin in a new zealand white rabbit model of brown recluse spider envenomation. | topical nitroglycerin has been reported to prevent skin necrosis from brown recluse spider bites, but this has never been scientifically tested. this study attempts to assess the effects of topical nitroglycerin on experimental loxosceles reclusa envenomations. | 2001 | 11174233 |
| topical antibiotic prophylaxis for bacteremia after dental extractions. | current prophylaxis for endocarditis in patients undergoing dental procedures consists of oral administration of amoxicillin. there is concern that the risk of anaphylaxis from systemically administered antibiotics might approach the incidence of endocarditis. emergence of resistance among bacteria is also favored by systemically administered antibiotics. the present study was designed to assess the efficacy of topical amoxicillin given prophylactically as a mouthwash in reducing the incidence o ... | 2001 | 11174592 |
| use of nucleotides in weanling rats with diarrhea induced by a lactose overload: effect on the evolution of diarrhea and weight and on the histopathology of intestine, liver and spleen. | until recently, dietary sources of nucleotides were thought not to be essential for good nutrition. certain states with higher metabolic demands may require larger amounts that cannot be provided by endogenous production. the objective of the present study was to determine the action of nucleotides on the recovery from lactose-induced diarrhea in weaned rats. thirty-six weanling fisher rats were divided into two groups. group 1 received a standard diet and group 2 received a diet containing lact ... | 2001 | 11175494 |
| genome-wide linkage analysis of inherited hydrocephalus in the h-tx rat. | inherited hydrocephalus in humans has received very little attention, most probably because known occurrences are sporadic and systematic investigation is difficult. the h-tx rat, one of a number of rodent strains with inherited hydrocephalus, has a complex inheritance with more than one postulated susceptibility gene and 40% penetrance. the aim of this study was to perform a genome-wide scan on backcross progeny derived from h-tx and fisher f344 rats, to identify genomic regions associated with ... | 2001 | 11178739 |
| radiotherapy after hyperbaric oxygenation improves radioresponse in experimental tumor models. | we examined the effect of radiotherapy after hyperbaric oxygen (hbo) breathing in experimental tumors using a tumor growth delay assay. tumor models used were sccvii (radiobiological hypoxic fraction: approximately 10%) and 9l tumors (containing less hypoxic cells) subcutaneously transplanted into c3h/he mice and fisher 344 rats, respectively. irradiation using x-rays was locally administered to the tumors immediately after decompression. hbo breathing enhanced the radiation response in sccvii t ... | 2001 | 11179829 |
| oxidative-stress-dependent up-regulation of bcl-2 expression in the central nervous system of aged fisher-344 rats. | oxidative stress has been shown to play a role in aging and in neurodegenerative disorders. some of the consequences of oxidative stress are dna base modifications, lipid peroxidation, and protein modifications such as formation of carbonyls and nitrotyrosine. these events may play a role in apoptosis, another factor in aging and neurodegeneration, in response to uncompensated oxidative stress. bcl-2 is a mitochondrial protein that protects neurons from apoptotic stimuli including oxidative stre ... | 2001 | 11181830 |
| gender differences in the effect of age on electrical field stimulation (efs)-induced adrenergic vasoconstriction in rat mesenteric resistance arteries. | the objective of this study was to examine the effects of gender and age on electrical field stimulation (efs)-induced vasoconstriction. fisher 344 rats were studied: young females (yf, n = 38), young males (ym, n = 29), old females (of, n = 33), and old males (om, n = 30). isolated mesenteric resistance arteries (endothelium-intact or denuded) were pressurized, and outer diameter was monitored. dose-response curves were performed to kcl and phenylephrine (pe). efs (0.1-16 hz) responses were exp ... | 2001 | 11181907 |
| ecology. pacific salmon run hot and cold. | using a novel technique, described on page 795, paleoceanographers have been able to chart the abundance of sockeye salmon in the bristol bay and kodiak island regions of alaska over the past 300 years--by far the most complete record yet. through time, they found, sockeye populations have alternately soared and slipped, following natural climate variations--well before commercial fishers began throwing nets over the sides of boats. | 2000 | 11184190 |
| il-10 kinetics in thyroiditis-prone bb/wor rats. | cytokines modulate the course of autoimmunity, but their role in the evolution of spontaneous disease is unclear. this study compared the cytokine kinetics of t cell cultures from thyroiditis (lt)-prone nb line bb/wor rats with those of wistar (wis) rat controls following activation with the thyroid-specific antigen thyroglobulin (tg) or concanavalin a (con a). | 2000 | 11191282 |
| a prospective study of p53 expression and its correlation with clinical response of radiotherapy in nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is a common malignant neoplasm of the head and neck that occurs in people in the southeastern asian area, including taiwan. the significant association of p53 expression in npc suggested that p53 overexpression seemed to occur at an early stage in the development of npc. alterations of p53 status were probably the most commonly encountered in head and neck carcinomas, and there was extensive evidence that p53 status might determine tumor response to therapy. ionizi ... | 2001 | 11192881 |
| hepatocyte isolation and transplantation in syngenic rats. | refinement of techniques to isolate viable hepatocytes began in the late 1960's. it was established that perfusion of the intact liver as opposed to incubation of liver slices or chopped tissue increased the yield of cells. the present study aims to establish a simple, two-step, collagenase digestion method for hepatocyte isolation. a single inbred fisher rat was used for hepatocyte isolation. the liver was perfused in-situ with perfusion buffer containing ethylene glycol bis n, n1, tetra acetic ... | 2000 | 11194586 |
| [radiation therapy after mastectomy--interdisciplinary consensus puts and end to a controversy. german society of senology]. | recent publications of the danish breast cancer cooperative group together with data from the british columbia trial have stirred major discussions concerning the role of radiation therapy after mastectomy. different treatment approaches are to be found even within the same cancer center. the german society of senology, a cooperative group of all medical disciplines involved in the treatment of breast cancer, has therefore worked out a consensus statement. | 2001 | 11200107 |
| analysis of anti-neutrophil cytoplasmic antibodies (anca): frequency and specificity in a sample of 191 homozygous (pizz) alpha1-antitrypsin-deficient subjects. | anca are autoantibodies directed against polymorphonuclear cell antigens, mainly proteinase 3 (pr3) and myeloperoxidase (mpo), which are implicated in the pathogenesis of small-vessel necrotizing vasculitis. alpha1-antitrypsin is the main inhibitor of neutral serine proteinase [i.e. human leukocyte elastase (hle) and pr3] present in pmn alpha-granules (alphagr). an association first reported by us between pr3 anca and the deficient pizz phenotype in anca-positive systemic vasculitis, now widely ... | 2001 | 11208991 |
| potent antitumor effects of intra-arterial injection of fibroblasts genetically engineered to express il-12 in liver metastasis model of rat: no additional benefit of using retroviral producer cell. | interleukin-12 (il-12) mediates significant antitumor effects in animal models but associated with dose-dependent toxicity in human. to achieve local expression of il-12 at the tumor site without systemic toxicity, we performed intra-arterial administration of fibroblasts genetically engineered to produce il-12 protein with or without retrovirus (crip- il-12 or 3t3-il-12) in liver metastasis model. rat breast cancer cells ( madb - 106) were injected into the portal vein of syngeneic fisher rats ... | 2001 | 11219489 |
| distal airspace enlargement in the fawn-hooded rat: influences of aging and alveolar wall destruction. | a recent study has revealed that the peripheral airspace in the lungs of the fawn-hooded rat (fhr) is enlarged. however, morphological and functional factors of the fhr lung have not been fully investigated. | 2001 | 11223735 |
| variations in the behavioral responses to apomorphine in different strains of rats. | the present experiments compared patterns of locomotor activity during repeated acclimation sessions and determinations of locomotion and stereotypy elicited by administration of the direct dopamine receptor agonist apomorphine in five inbred strains of rats: the results suggest that each strain can be differentiated phenotypically according to these behavioral responses. brown norway rats demonstrated the greatest locomotion during acclimation sessions. low doses of apomorphine (0.1 and 0.32mg/ ... | 1995 | 11224306 |
| altered muc1 and muc2 glycoprotein expression in laryngeal cancer. | the purpose of this study was to determine whether mucin expression is altered in laryngeal cancer. muc1 and muc2 mucin expression was examined in biopsy specimens from 80 patients that comprised 23 laryngeal dysplasias, 36 laryngeal carcinomas, and 21 normal larynx control specimens. high muc1 expression was found in all 3 groups (p = 0.689, fisher exact test). however, significantly higher levels of muc2 expression were detected in carcinomas compared with dysplasias and control specimens (p = ... | 2001 | 11226957 |
| velocardiofacial syndrome: are structural changes in the temporal and mesial temporal regions related to schizophrenia? | velocardiofacial syndrome results from a microdeletion on chromosome 22 (22q11.2). clinical studies indicate that more than 30% of children with the syndrome will develop schizophrenia. the authors sought to determine whether neuroanatomical features in velocardiofacial syndrome are similar to those reported in the literature on schizophrenia by measuring the volumes of the temporal lobe, superior temporal gyrus, and mesial temporal structures in children and adolescents with velocardiofacial sy ... | 2001 | 11229987 |
| identification of enteropathogenic escherichia coli in simian immunodeficiency virus-infected infant and adult rhesus macaques. | enteropathogenic escherichia coli (epec) was recognized as a common opportunistic pathogen of simian immunodeficiency virus-infected rhesus macaques (macaca mulatta) with aids. retrospective analysis revealed that 27 of 96 (28.1%) animals with aids had features of epec infection, and epec was the most frequent pathogen of the gastrointestinal tract identified morphologically. in 7.3% of animals dying with aids, epec represented the sole opportunistic agent of the gastrointestinal tract at death. ... | 2001 | 11230413 |
| increased dietary salt accelerates chronic allograft nephropathy in rats. | chronic allograft nephropathy (can), a major problem in renal transplantation, is related to both alloantigen-dependent and -independent processes. because dietary salt intake modulated glomerular production of transforming growth factor-beta, which has been shown to play an important role in can, we hypothesized that dietary salt would directly enhance renal injury in a rodent model of can. | 2001 | 11231373 |
| specific organ gene transfer in vivo by regional organ perfusion with herpes viral amplicon vectors: implications for local gene therapy. | many gene therapy strategies would benefit from efficient, regional organ delivery of therapeutic genes. | 2001 | 11231461 |
| transition between stochastic evolution and deterministic evolution in the presence of selection: general theory and application to virology. | we present here a self-contained analytic review of the role of stochastic factors acting on a virus population. we develop a simple one-locus, two-allele model of a haploid population of constant size including the factors of random drift, purifying selection, and random mutation. we consider different virological experiments: accumulation and reversion of deleterious mutations, competition between mutant and wild-type viruses, gene fixation, mutation frequencies at the steady state, divergence ... | 2001 | 11238990 |
| the hla-dqb alleles and amino acid variants of the vitamin d-binding protein in diabetic patients in alsace. | the hla-dqb1 chain, in particular the amino acid in position 57, and genetic variants of the vitamin d-binding protein (dbp) have been reported to be associated with type 1 diabetes. there are two known polymorphisms in exon 11 of the dbp gene resulting in amino acid variants: codons 416 gat --> gag (asp --> glu) and 420 acg --> aag (thr --> lys). we compared distribution of dqb1 alleles and amino acid variants of dbp in type 1 diabetic patients (n = 44) in the alsacian population and in healthy ... | 2001 | 11239517 |
| effects of spaceflight and cage design on abdominal muscles of male rodents. | we examined the effects of a 16-day spaceflight mission on the size of muscle fibers in the rectus abdominis, external oblique and transversus abdominis muscles of adult male fisher rats. the rats were individually housed in orbit, in contrast to the one previous spaceflight investigation of the same muscles, where the rats were group-housed pregnant females. the cross-sectional area of the muscle fibers was used as a measure of muscle atrophy or hypertrophy. the transversus, which is presumed t ... | 2001 | 11241404 |
| [relationship between oval cells and preneoplastic lesions induced by 2-acetylaminofluorene in rat liver]. | to study the cellular origin of preneoplastic lesion of liver induced by the 2-acetylaminofluorene (2-aaf) in rat. | 1998 | 11244968 |
| age-related changes in the urinary excretion of aldehydes in ad libitum fed and food-restricted rats. | age-related changes in the urinary excretion of aldehydes arising from lipid peroxidation have been investigated in male sprague-dawley rats aged 2, 4, 6, 12, 18, 24 and 27 months, fed ad libitum or subjected to two different regimens of calorie restriction (namely every-other-day ad libitum feeding--eod--and 40% calorie restriction--40%dr). for only some age groups, results were compared with those obtained in ad libitum fed male fisher 344 and lewis rats. results show that the urinary excretio ... | 2001 | 11250122 |
| guillain-barré syndrome- and miller fisher syndrome-associated campylobacter jejuni lipopolysaccharides induce anti-gm1 and anti-gq1b antibodies in rabbits. | campylobacter jejuni infections are thought to induce antiganglioside antibodies in patients with guillain-barré syndrome (gbs) and miller fisher syndrome (mfs) by molecular mimicry between c. jejuni lipopolysaccharides (lps) and gangliosides. we used purified lps fractions from five campylobacter strains to induce antiganglioside responses in rabbits. the animals that received injections with lps from gbs-associated strains developed anti-gm1 and anti-ga1 antibodies. animals injected with lps f ... | 2001 | 11254608 |
| variations of dose and electrode spacing for rat breast cancer electrochemical treatment. | electrochemical treatment (echt) with direct current delivered through implanted electrodes has been used for local control of solid tumors in humans. this study tested the hypothesis that rat breast cancer responses to echt are dependent on electrode spacing and dose, and explored suitable parameters for treating breast cancers with echt. rat breast cancers were initiated by injecting 1 x 10(6) mtf-7 cells to the right mammary gland fat pad of fisher 344 female rats. the rats were randomly divi ... | 2001 | 11255217 |
| [cryptosporidium parvum infection in malnourished and non malnourished children without diarrhea in a mexican rural population]. | cryptosporidium parvum is associated with diarrheic disease and mainly affects children and immunocompromised hosts. in most of the cases, cryptosporidiosis infection is asymptomatic in immunocompetent subjects. the objectives of the study were to determine the frequency of asymptomatic infection caused by the parasite in children with and without malnutrition and to determine the risk factors associated to infection. | 2000 | 11256105 |
| [characterization and distribution of citrobacter species in a university hospital]. | [corrected] a) to identify citrobacter strains following the conventional biochemical reaction of brenner and col; b) to evaluate the sensitivity and specificity of the o'hara's method compared with brenner's method, and c) to determine the rate and distribution of the strains in the clinical isolates. | 2001 | 11256240 |
| transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: effects of different cytotoxins on cytochrome p450 mediated monooxygenase functions and on oxidative state. | syngenic fetal liver tissue suspensions were transplanted into the spleens of adult male fisher 344 inbred rats. four months after surgery, transplant recipients and age matched control rats were treated with different cytotoxins (allyl alcohol [aal], bromobenzene [bbz], carbon tetrachloride [ccl4], or thioacetamide [taa]) or the respective solvents 24 or 48 hours before sacrifice. effects of the cytotoxins on p450 mediated monooxygenase functions in liver and spleen 9,000 g supernatants were as ... | 2001 | 11256755 |
| [a case of anti-gq1b-positive atypical fisher syndrome with internal ophthalmoplegia but without external ophthalmoplegia]. | we report a 21-year-old man who developed an atypical form of fisher syndrome. one week after having a common cold, he was admitted to our hospital because of a gait disturbance. neurological examination revealed a somnolent state, cerebellar ataxia, areflexia, limb muscle weakness, and numbness in a glove and stocking like distribution. the patient had internal ophthalmoplegia but did not have external ophthalmoplegia. brain mri showed no abnormality in the orbital and the pretegmental brain re ... | 2000 | 11257783 |
| novel cftr chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds. | the flavonoid genistein and the benzo[c]quinolizinium mpb-07 have been shown to activate the cystic fibrosis transmembrane conductance regulator (cftr), the protein that is defective in cystic fibrosis. lead-based combinatorial and parallel synthesis yielded 223 flavonoid, quinolizinium, and related heterocyclic compounds. the compounds were screened for their ability to activate cftr at 50 microm concentration by measurement of the kinetics of iodide influx in fisher rat thyroid cells expressin ... | 2001 | 11262417 |
| promoter region-based classification of genes. | in this paper we consider the problem of extracting information from the upstream untranslated regions of genes to make predictions about their transcriptional regulation. we present a method for classifying genes based on motif-based hidden markov models (hmms) of their promoter regions. sequence motifs discovered in yeast promoters are used to construct hmms that include parameters describing the number and relative locations of motifs within each sequence. each model provides a fisher kernel ... | 2001 | 11262936 |
| perturbations of arginine vasopressin secretion during inflammatory stress. pathophysiologic implications. | pro-inflammatory cytokines, such as interleukin-1 beta (il-1 beta), interleukin-6 (il-6), and tumor necrosis factor-alpha (tnf alpha), released from inflammatory foci, can activate the hypothalamus to produce corticotrophin-releasing hormone (crh) and arginine vasopressin (avp). these hypothalamic peptides in synergy increase acth production by the pituitary gland and hence corticosteroid (cs) secretion by the adrenal cortices. cs dampens inflammation. the pituitary also produces prolactin (prl) ... | 2000 | 11268412 |
| host leukocytes and their products in chronic kidney allograft rejection in rats. | bilaterally nephrectomized lewis recipients of fisher 344 (f344) kidney allografts, treated with cya (1.5 mg/kg/day x 10), develop progressive changes of chronic rejection. treated f344-to-f344 acted as isograft controls. proteinuria was determined sequentially. grafts were harvested 8, 12 and 16 weeks after transplantation (n = 9/group/time period). infiltrating host cells and their products were assessed in chronically rejecting grafts by histology and immunostaining using mabs for monocyte/ma ... | 1994 | 11271242 |
| the effects of single lung transplantation in rats with monocrotaline-induced pulmonary hypertension. | acute haemodynamic change after single lung transplantation for primary pulmonary hypertension was evaluated using a rat transplantation model. inbred fisher 344 rats were administered with 40 mg/kg monocrotaline in order to induce pulmonary hypertension. the rats whose mean pulmonary arterial pressure (pap) was over 30.0 mm hg received a left lung isograft from a normal donor after right heart catheterization. in the control group, pap increased after single lung transplantation. on the other h ... | 1994 | 11271262 |
| randomized placebo-controlled evaluation of intramuscular interferon beta treatment of recurrent human papillomavirus. | to evaluate the effectiveness and safety of interferon beta in women with recurrent cervical human papillomavirus (hpv) lesions. | 2001 | 11275039 |
| nuclear localization of beta-catenin is an important prognostic factor in hepatoblastoma. | in this study, mutational and immunohistochemical analyses of beta-catenin were performed in 30 hepatoblastomas, to assess the prevalence of alterations of the wnt pathway with respect to clinicopathological parameters and survival. four missense mutations of beta-catenin (13.3%) were detected and there was strong immunoreactivity for beta-catenin in the cytoplasm and/or the nucleus in 97% of hepatoblastomas. nuclear and cytoplasmic staining was demonstrated in 19 of 30 tumours (63%), while ten ... | 2001 | 11276007 |
| intraabdominal vancomycin-resistant enterococcus infections: the new threat. | to determine the clinical course and outcome in patients with intraabdominal vancomycin-resistant enterococcus infections (vre-a) and to identify probable risk factors for vre-a. | 2001 | 11276278 |
| a clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay. | a combination of experimental and simulation approaches were used to analyze the clonal growth of preneoplastic, enzyme-altered foci during liver carcinogenesis in an initiation-promotion regimen. male fisher 344 rats, 8 weeks of age, were initiated with a single dose (200 mg/kg, i.p.) of diethylnitrosamine (den). beginning 2 weeks later, animals were exposed to daily gavage consisting of 0.1 mmol/kg pentachlorobenzene (pecb) or hexachlorobenzene (hcb) in corn oil vehicle for 6 weeks. partial he ... | 2001 | 11280742 |
| effect of age on electrical field stimulation (efs)-induced endothelium-dependent vasodilation in male and female rats. | the purpose of this study was to determine whether the effect of age on electrical field stimulation (efs)-induced endothelium-dependent vasodilation was different in males and females. | 2001 | 11282086 |
| perivascular release of insulin-like growth factor-1 limits neointima formation in the balloon-injured artery by redirecting smooth muscle cell migration. | insulin-like growth factor-1 (igf-1) is a potent chemoattractant to vascular smooth muscle cells (smcs). the authors hypothesize that perivascular release of igf-1 in vivo can direct migration of smcs away from the lumen and reduce neointima formation in a rabbit model of arterial balloon injury. | 2001 | 11287513 |
| neurohistochemical analysis of regeneration in rat peripheral nerve after end-to-side neurorrhaphy. | we investigated the regenerative capacity of motor nerves repaired by end-to-side or end-to-end neurorrhaphy, using choline-acetyltransferase (chat) activity measurement or histological analysis. the right medial gastrocnemius nerves (mgns) of 62 male fisher strain rats were transected and divided into three groups. in group 1, the distal ends of the mgn were coapted to the side of the lateral gastrocnemius nerve, using a y-shaped silicone tube in end-to-side neurorrhaphy. in group 2, the nerve ... | 2001 | 11289591 |
| effects of age and strain on small intestinal and hepatic antioxidant defense enzymes in wistar and fisher 344 rats. | age- and strain-associated alterations in intestinal and hepatic antioxidant defense enzymes including superoxide dismutase (sod), glutathione peroxidase (gsh-px), and glutathione-s-transferase (gst), and lipid peroxidation were examined in wistar and f344 rats of both strains aged 2 weeks, 2.5, 10 and 23 months. in the small intestine, activities of sod and gsh-px and lipid peroxidation were not affected by age or strain difference. intestinal gst activity was noticeably increased with age in b ... | 2001 | 11295172 |
| biological aging does not lead to the accumulation of oxidized cu,zn-superoxide dismutase in the liver of f344 rats. | cu,zn-superoxide dismutase (sod) was isolated from the liver of 3-, 12-, and 26-month-old fisher 344 (f344) rats. specific activity and metal content of the enzyme, purified by ion-exchange and size-exclusion chromatography, did not significantly change with age. electrospray ionization-mass spectrometry and amino acid analysis of cu,zn-sod apoprotein, further purified by reverse-phase hplc, showed neither significant loss of amino acids nor accumulation of oxidized isoforms with age. when bovin ... | 2001 | 11295528 |
| [a case of miller fisher syndrome with pharyngeal palsy as an initial symptom]. | we report herein a rare case of miller fisher syndrome with pharyngeal palsy as an initial symptom. a 68-year-old man admitted to our hospital with pharyngeal palsy two weeks after a respiratory infection. he subsequently developed ataxic gait, paresthesia in the upper limbs and ophthalmoplegia. double-filtrated-plasmapheresis had been performed four times and all the symptoms subsided within two months. in the acute phase of the disease, the titers of anti-gq1b and gt1a antibodies were elevated ... | 2001 | 11296403 |
| calorie restriction attenuates inflammatory responses to myocardial ischemia-reperfusion injury. | the life-prolonging effects of calorie restriction (cr) may be due to reduced damage from cumulative oxidative stress. our goal was to determine the long-term effects of moderate dietary cr on the myocardial response to reperfusion after a single episode of sublethal ischemia. male fisher 344 rats were fed either an ad libitum (al) or cr (40% less calories) diet. at age 12 mo the animals were anaesthetized and subjected to thoracotomy and a 15-min left-anterior descending coronary artery occlusi ... | 2001 | 11299211 |
| possible prevention by abieslactone of development of diethylnitrosamine-initiated gst-p positive foci in the rat liver. | triterpenoid compounds, isolated from plants of abies genus (pinceae), are known to exert anti-tumor promotion activities in mouse skin carcinogenesis. in the present study, we investigated whether avb-1 and acid and acid methyl ester derivatives have inhibitory effects on rat hepatocarcinogenesis by using a liver medium-term bioassay for carcinogens (ito's test), immunohistochemically assessing the numbers and areas per cm(2) of preneoplastic lesions, glutathione s-transferase placental form (g ... | 2001 | 11301417 |
| mild gestational hypertension remote from term: progression and outcome. | limited information is available regarding the progression of disease in women with mild gestational hypertension. our purpose was to describe the prognostic signs in the natural course of mild gestational hypertension and pregnancy outcomes in women who were remote from term with mild gestational hypertension that was expectantly managed. | 2001 | 11303208 |
| increased prevalence of helicobacter pylori in patients with diabetes mellitus. | whilst upper gastrointestinal disturbances are frequently observed in patients with diabetes mellitus, little is known about the prevalence of helicobacter pylori infection and peptic disease in these patients. | 2001 | 11303971 |
| cut-off point, timing and pitfalls of the 13c-urea breath test as measured by infrared spectrometry. | the best timing and the best cut-off level of the 13c-urea breath test have not yet been well established. | 2001 | 11303972 |
| distal bowel selectivity in the chemoprevention of experimental colon carcinogenesis by the non-steroidal anti-inflammatory drug nabumetone. | use of non-steroidal anti-inflammatory drugs (nsaids) for chemoprevention of colon cancer has been hindered by their potential gastro-intestinal toxicity. nabumetone, which is approximately 10 to 36 times safer than conventional nsaids, was evaluated in 2 models of experimental colon carcinogenesis. in azoxymethane (aom)-treated fisher 344 rats, nabumetone caused dose-dependent inhibition of aberrant crypt foci (acf), with 750 and 1,500 ppm resulting in 15% and 37% reductions, respectively (p < ... | 2001 | 11304699 |
| miller fisher syndrome: immunofluorescence and immunoelectron microscopic localization of igg at the mouse neuromuscular junction. | in vitro electrophysiological experiments have demonstrated that igg antibodies from patients with miller fisher syndrome (mfs) impair neuromuscular transmission by a fast and completely reversible combined pre- and postsynaptic blockade. in this study we investigated the cellular and subcellular binding sites of igg from four mfs patients at the mouse hemidiaphragm by immunofluorescence and immunoelectron microscopy. igg from all patients produced significant immunostaining at the neuromuscular ... | 2001 | 11307623 |
| mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells. | the female reproductive toxicity of di-(2-ethylhexyl) phthalate and its active metabolite mono-(2-ethylhexyl) phthalate (mehp) is attributed to suppression of ovarian granulosa cell estradiol production. in these studies, several structurally related phthalates (0-200 microm) and wy-14,643 (0-100 microm) were compared to mehp for their effects on granulosa cell estradiol production and transcript levels of cytochrome p450 enzyme cyp 19, also known as aromatase (p450arom), the rate-limiting enzym ... | 2001 | 11312650 |
| vascular endothelial growth factor and soft tissue sarcomas: tumor expression correlates with grade. | vascular endothelial growth factor (vegf), an endothelial-specific mitogen overexpressed in various epithelial malignancies is thought to be a potent regulator of angiogenesis. we hypothesized that some soft tissue sarcomas, due to their high propensity for hematogenous metastases (1) would overexpress vegf, (2) that the degree of expression may represent a significant biologic predictor for disease-specific survival, and (3) that recurrent tumor would express as high or higher vegf compared wit ... | 2001 | 11314944 |
| the influence of somatostatin on bacterial translocation. | bacterial translocation is defined as the passage of bacteria from the gastrointestinal tract to extraintestinal sites mostly as a consequence of the loss of the gut barrier function. somatostatin and octreotide, exerting many inhibitory effects on the gastrointestinal tract, have been evidenced to promote bacterial translocation. | 2001 | 11319512 |