| acquired agammaglobulinemia after a life-threatening illness with clinical and laboratory features of infectious mononucleosis in three related male children. | three males in one family (two siblings and one maternal cousin) had an illness with cervical adenopathy, hepatosplenomegaly, and a fulminant febrile course. in the two survivors agammaglobulinemia developed. one of them became ill at the age of six months and had an epstein-barr-virus antibody titer of 1:10 during illness and convalescence. the white-cell count was 120,000 with 90 per cent lymphocytes, most being atypical and forming increased numbers of sheep erythrocyte rosettes. igm was elev ... | 1975 | 165416 |
| cyclic amp and immune responses: changes in the splenic level of cyclic amp during the response of mice to antigen. | intravenous injection of sheep erythrocytes into normal immunologically competent c57bl/6j mice results in significant and characteristic changes in the splenic level of 3':5'-camp with initiation of the immune response and proliferation of antibody-forming cells. the level increases 2- to 3-fold initially, peaks at 2 min, and returns to base level in an hour. between 2 and 5 days there is a decrease, followed by a peak when the rate of proliferation of antibody-forming cells is maximal. changes ... | 1975 | 165492 |
| serum alkaline phosphatase activity in relation to liveweight of lambs. | groups of lambs were fed four levels of a diet based upon oaten grain. two groups gained weight rapidly, one less rapidly and the other lost liveweight over a 32-day period. serum alkaline phosphatase activity was found to be closely correlated to liveweight, in a positive linear manner, in those lambs gaining weight rapidly. this relationship was similar in lambs of r or r blood group. supplementation of the diet with limestone and or sodium chloride did not influence the relationship. this rel ... | 1975 | 165570 |
| the incidence of antibody to infectious bovine rhinotracheitis virus in kenyan cattle. | a total of 3204 cattle sera, collected between 1966 and 1974, from all seven provinces and 34 of the 42 districts of kenya were screened in a neutralisation test for antibody to infectious bovine rhinotracheitis virus (ibrv). antibody to ibrv was found in some sera from all the districts, with cattle over two years old showing the highest incidence. a small number of goat sera also showed some antibody. from the results obtained it is concluded that ibrv infection is widespread in kenyan cattle. | 1975 | 165572 |
| procaine amide-induced vacuolation in macrophages and effects on endocytic activity. | | 1975 | 165591 |
| an experimental inactivated vaccine against bluetongue. | bluetongue virus grown in bhk cells was shown to be inactivated in concentrations of betapropiolactone (bpl) higher than 0-15 per cent. when the virus, inactivated with 0-2 per cent bpl and prepared as a double emulsion vaccine, was injected into cypriot sheep, no untoward reactions were observed and neutralising antibodies developed. the antibody titre reached a high level and persisted for at least a year. after re-vaccination, a secondary response was observed. a bivalent vaccine elicited a ... | 1975 | 165609 |
| persistent or slow viral infections and related diseases. | the discovery of persistent transmissible agents by veterinarians has led to striking advances in the infectious cause of neuropathies of human beings. there is evidence for persisting infection in congenital rubella and the herpes group of viruses including cytomegalovirus infections. hepatitis types a and b are candidates for inclusion in the category of persisting viral infections. the rubeola or measles virus is established as a persistent virus which causes elevated antibodies in the serum ... | 1975 | 165638 |
| early cellular events in the response of mice to sheep red blood cells reflected by changes in the spleen level of cyclic amp. | | 1975 | 165767 |
| stimulation of camp levels and modulation of antibody formation in mice immunized with cholera toxin. | injection of mice with 1.0 mu g of a purified exotoxin derived from vitro cholerae together with a challenge injection of sheep erythrocytes (srbc)p or e. coli lps markedly influenced the immune response to these antigens. simultaneous injection of the toxin with antigen resulted in a delayed appearance of antibody-forming cells during the first few days after immunization, followed by a marked enhancement of the peak numbers of antibody-forming cells. in the case of the immune response to srbc, ... | 1975 | 165769 |
| the effects of interstitial cell-stimulating hormone, its subunits, and recombinants on isolated rat leydig cells. | | 1975 | 165777 |
| isopynic separation of ram spermatids in colloidal silica gradients. | | 1975 | 165959 |
| the evolution of vertebrate corticotrophin and melanocyte stimulating hormone. | | 1975 | 166013 |
| immunodeficiency in the chicken. i. disparity in suppression of antibody responses to various antigens following surgical bursectomy. | the extent of suppression of antibody response by bursectomy (bx) was examined as a measure of the seeding sequence of different clones from the bursa to peripheral lymphoid tissues. chickens were bursectomized surgically 1, 4 or 7 days after hatching and immunized later with four antigens: sheep red blood cells (srbc); bordetella pertussis (bp); human serum albumin (hsa); influenza virus (iv). the kinetics of the antibody responses were delayed in bursectomized birds when compared with the cont ... | 1975 | 166036 |
| an electron microscopic study of the histogenesis of the parathyroid gland in the sheep. | definitive chief cells, characterized by the presence of specific secretory granules and typical membrane configurations, were present in the developing parathyroid glands of sheep embryos from 26 days of gestation (term = 150 days). during earlier stages of gestation developing chief cells contained lysosomal systems which appeared to be concerned with the autophagy of retained secretion product. the em evidence suggests that physiologic release of the hormone does not occur until at least 30 d ... | 1975 | 166064 |
| proceedings: metabolism of oestrone sulphate and binding of oestrogens by the brain and pituitary of foetal and adult sheep. | | 1975 | 166123 |
| binding of ovine 125-i-prolactin to cultured anterior pituitary tumour cells and normal cells. | | 1975 | 166318 |
| proceedings: the visna provirus and slow virus disease. | | 1975 | 166333 |
| [everyday research 1. researchers who serve 2 masters try to solve the mystery of virus infections]. | | 1975 | 166351 |
| antigen-stimulated changes in cyclic nucleotide levels in the mouse. | mice injected intravenously with sheep erythrocytes (srbc) demonstrate a transient increase in splenic camp levels (4-fold), which peak at 2 min after injection and return to basal levels by 20 min. in addition to the change in camp, an increase in splenic cgmp levels (1.5-fold) occurs beginning 5-10 min after srbc injection, and persists for up to 7 days. during this period camp levels remain at or below control levels in the spleen. there is no change in 3':5' cyclic nucleotide levels in the l ... | 1975 | 166385 |
| [forensic medical study of ashes containing small fragments of bones (an experimental study)]. | | 1975 | 166464 |
| [etiology of anaerobic infections in cattle and sheep in latin america. i. field experience and laboratory research]. | | 1975 | 166532 |
| the ontogeny and regulation of corticosteroid secretion by the ovine foetal adrenal. | adrenal glands of foetal sheep of 40 days gestation to term were incubated with and without acth or an increased [k-+]. with acth, the 40 day foetal adrenal was capable of producing more cortisol and aldosterone per g body weight than was the term adrenal. acth was a potent stimulus to aldosterone and cortisol production in foetuses aged 60-90 days, and this effect declined significantly in the 91-120 day period. an increased [k-+] was stimulatory to aldosterone production only after 120 days ge ... | 1975 | 166536 |
| phagocytosis of lymphoblastoid cells and cell destruction of human malignant tumor cells. | on the basis of the previous study, on the cell interaction between malignant tumor cells and other cells, especially with lymphocytes, the present study was carried out by investigating cell to cell interaction of human malignant tumor cells and human lymphoblastoid cells such as t-cell (molt-4 cell) and b-cell (burkitt lymphoma cell). as a result it has been revealed that live lymphoblastoid cells were not adhered on the cell surface of the tumor cells, nor is it ingested by tumor cells, but i ... | 1975 | 166555 |
| [etiology, clinical aspects and prevention of aphtous fever]. | | 1975 | 166583 |
| enzyme profiles of mammalian bile. | the activities of subcellular marker enzymes in bile and liver homogenate from several mammalian species have provided information on the specificity of protein release during bile formation. the presence of significant amounts of the plasma membrane enzymes alkaline phosphodiesterase i and leucyl-beta-naphthylamidase in bile, in addition to alkaline phosphatase and 5'-nucleotidase, and the relative absence of intracellular enzymes lends support to the view that bile salt liberation from the hep ... | 1975 | 166672 |
| assay of lactogenic hormones using receptors isolated from rabbit liver. | using 125-i-labelled ovine prolactin and receptors isolated from the livers of rabbits, a sensitive method has been developed suitable for the assay of ovine, bovine, porcine, human and rat prolactins. these hormones showed competitive displacement of 125-i-ovine prolactin which was in general agreement with their respective activities in the pigeon crop sac bioassay. human and monkey growth hormones and human placental lactogen, which have marked prolactin-like actions on mammary tissue were al ... | 1975 | 166819 |
| the mechanism of acth stimulation of adrenal ornithine decarboxylase activity. | the mechanism of action of adrenocorticotrophin (acth) stimulation of rat adrenal orticotrophin (acth) stimulation of rat adrenal ornithine decarboxylase activity was investigated. acth induction or ornithine decarboxylase activity was not prevented by administration of drugs that inhibit adrenal steroid biosynthesis. a dose of acth that produced maximal levels of adrenal cyclic amp did not induce ornthine decarboxylase activity. ovine growth hormone, which caused no increase in adrenal cyclic a ... | 1975 | 166825 |
| immunological sequelae of trichinella spiralis infection in mice: effect on the antibody responses to sheep erythrocytes and japanse b encephalitis virus. | immunosuppression of the antibody response to japanese b encephalitis (jbe) virus and sheep erythrocytes (srbc) was observed in mice infected with trichinella spiralis. this suppression was paralleled by the presence of fewer antibody-forming cells to srbc in the spleens of parasitized mice. both primary and secondary complement-fixing antibody responses to jbe virus were suppressed, but the development of immunological memory was not affected. parasitized mice demonstrated a normal blastogenic ... | 1975 | 166916 |
| interactions between aerolysin, erythrocytes, and erythrocyte membranes. | aerolysin, a hemolytic and lethal exotoxin of aeromonas hydrophila, was analyzed for amino acids. assuming 8 histidine residues/mol, the purified toxic protein has, by summation, a molecular weight of 49,000, a value in agreement with earlier estimates by other methods. erythrocytes from different animal species differ greatly in sensitivity to aerolysin's lytic action. there is some correlation between sensitivity and phosphatidyl choline content. erythrocyte membranes of different species bind ... | 1975 | 166917 |
| argentation thin-layer chromatography of fatty acid methyl esters on silufol uv 254 sheets. | | 1975 | 167045 |
| experimental infection of red grouse with louping-ill virus (flavivirus group). i. the viraemia and antibody response. | | 1975 | 167055 |
| the reaction of pregnant ewes to inoculation with mucosal disease virus of bovine origin. | | 1975 | 167056 |
| warts in sheep. identification of a papilloma virus and transmission of infection to sheep. | | 1975 | 167057 |
| studies with foot-and-mouth disease virus in british deer (muntjac and sika). clinical disease, recovery of virus and serological response. | | 1975 | 167058 |
| the identification and purification of multiple forms of theta-haemolysin (theta-toxin) of clostridium perfringens type a. | the theta-haemolysin of clostridium perfringens was purified from culture supernatant fluids of type a strains by fractional ammonium sulphate precipitation and isoelectric focusing in narrow ph 5 to 8 gradients. four components detected on electrofocusing were designated theta-1(pi6-8to6-9),theta-2(pi6-5to6-6),theta-3(pi6-1to6-3) and theta-4(pi5-7to5-9). specific activities ranged from 0-4 x 10-6 to 1-2 x 10-6 haemolytic units/mg protein and 2950 to 3600 ld-50/mg protein. each haemolytic compon ... | 1975 | 167102 |
| plasma adrenocorticotrophin concentration during induction of parturition by the intravascular infusion of physiological amounts of cortisol into the sheep foetus. | | 1975 | 167155 |
| the demonstration by interference tests of an infective agent in fetuses from ewes inoculated with border disease tissue. | fetuses and placental tissues were taken from pregnant ewes at intervals varying between eight and 21 days after inoculation with tissue suspensions from cases of border disease. virus isolation procedures involving the detection of a cytopathic effect in tissue cultures with or without interference tests produced universally negative results but interference tests, using a plaque technique with the nadl strain of bovine virus diarrhoea virus as a challenge virus, detected the presence of an age ... | 1975 | 167408 |
| improved platelet economy using filler free silicone rubber in long term membrane lung perfusion. | | 1975 | 167494 |
| foot-and-mouth disease in british deer: transmission of virus to cattle, sheep and deer. | after exposure for two hours to cattle with foot-and-mouth disease, each of the five species of deer found in the british countryside became infected. clinical disease was typical and severe in the roe and muntjac deer, with some animals dying, less severe in the sika deer and usually subclinical in the fallow and red deer. each species transmitted disease to its own species and to cattle and sheep. the amounts of virus present in the blood, and in oesophageal/pharyngeal samples and excreted as ... | 1975 | 167503 |
| newer knowledge in comparative virology--its contribution to human health research. | like other comparative sciences, and despite its recent beginning comparative virology has already contributed useful applications and observations to human health research. teachings derived from the study of marek's disease found application in that of burkitt's lymphoma, and may lead to a possible vaccine against the human disease. equally useful information came from the study of canine distemper in the development of a chorio-allantoic membrane attenuated measles vaccine, and in our knowled ... | 1975 | 167504 |
| polymyxin b reactions, ige antibody, and t-cell deficiency. immunochemical studies in a patient after bone marrow transplantation. | a patient with aplastic anemia was immunosuppressed with cyclophosphamide and transplanted with allogenic bone marrow. while lacking demonstrable t-cell activity posttransplantation, he developed a generalized macular erythematous eruption and fever, clinically attributed to intranasal polymyxin b. a specific ige antibody, demonstrated by direct skin testing, prausnitz-kustner passive transfer, and indirect passive hemagglutination was temporally related to the reaction. discontinuation of the d ... | 1975 | 167631 |
| physiological and pharmacological roles of prostaglandins. | | 1975 | 167656 |
| purification of a lactogenic hormone in sheep placenta. | | 1975 | 167784 |
| the pituitary dwarf mouse: a model for study of endocrine immunodeficiency disease. | pituitary dwarf mutants of the snell-bagg and ames mouse strains develop severe immunodeficiency of the thymus-dependent system which frequently leads to a fatal wasting syndrome. this immunodeficiency is a consequence of defective pituitary influences which will cause 1) an inadequate production of immunocompetent cells due to a central developmental defect primarily affecting the thymus and 2) the inability of immunocompetent cells to undergo a rapid and efficient antigen-induced proliferation ... | 1975 | 167885 |
| an immunoprecipitin study of the incidence of influenza a antibodies in animal sera in the ottawa area. | a survey of over 600 'normal' sera from 14 animal species by immunoprecipitin tests in cellulose acetate using viron antigens revealed a high incidence of precipitating activity against a broad range of influenza a virus strains, particularly a2hhong kong/1/68 and /pr8. however, serum treatments trypsin-heat-periodate, naio4, v. cholerae receptor-destroying enzyme (rde), or kaolin eliminated most precipitating activity, which suggests that it was due to "non-specific" inhibitors of influenze vir ... | 1975 | 167931 |
| red cell enzymes--ii. enzyme activities in the red blood cells of high and low potassium sheep. | | 1975 | 168029 |
| red cell enzymes--iii. enzyme activities in the red blood cells of different breeds of sheep. | | 1975 | 168030 |
| guanidination of ovine luteinizing hormone and effects on activity. | the free amino groups in olh, olhalpha and olhbeta were guanidinated by o-methylisourea. the epsilon-nh2 groups of lysine residues reacted bo substitute these positions in the sequence with the more basic homoarginine residue. the alpha-nh2 groups did not react under the conditions used. guanidinated olh or the products of guanidinated olhalpha + native olhbeta or guanidinated olhalpha + guanidinated olhbeta were inactive in two bioassay systems. native olhalpha + guanidinated olhbeta, however, ... | 1975 | 168055 |
| the metabolism of luteinizing hormone. plasma clearance, urinary excretion, and tissue uptake. | the kinetics of plasma clearance, tissue uptake, and urinary excretion of tritiated ovine pituitary luteinizing hormone in adult male rats are reported. most of the intravenously injected tritiated gonadotropin is cleared from circulation with a half-life of five minutes, and this is independent of the injected amount of hormone over a wide dose range. it was found that the hormone is rapidly removed from circulation by the kidneys, probably by glomerular filtration, and excreted in the urine. t ... | 1975 | 168103 |
| effects of follicle-stimulating hormone on cultures of sertoli cell preparations. | sertoli cell-enriched preparations were obtained by sequential enzyme treatment of testes of 18-20 day old rats, and were maintained in culture in a chemically defined medium. the addition of highly purified follicle-stimulating hormone (fsh) to cells immediately after preparation, or after 48 h in culture, elicited an increase in the level of cyclic adenosine 3',5'-monophosphate (camp) when incubated in the presence of 3-isobutyl-1-methylxanthine (mix). luteinizing hormone (lh) had no effect on ... | 1975 | 168104 |
| streptovirudins, new antibiotics with antibacterial and antiviral activity. i. culture taxonomy, fermentation and production of streptovirudin complex. | a new antibiotic complex has been isolated from cultures of streptomyces strain no. ja 10124. on the basis of taxonomic studies, the producing microorganism is described as streptomyces griseoflavus (krainsky, 1914) waksman et henrici, 1948, subsp. thuringiensis subsp. nov., type strain ja 10124. the antibiotic complex, designated as streptovirudin, was isolated from extracts of both mycelium and culture filtrate. it is a white amorphous material which consists of ten closely related components ... | 1975 | 168173 |
| immunologic effects of neonatal infection with mouse thymic virus. | mouse thymic virus is a herpesvirus that causes extensive thymic necrosis when given to newborn mice. during the time of acute infection spleen cells have markedly diminished reactivity to t cell phytomitogens and to allogeneic cells and are incapable of effecting a primary in vitro response to a "t-dependent" antigen; responses to b cell mitogens and to a t-independent antigen are unimpaired. spleens from acutely infected mice have low theta antigen normal numbers of immunoglobulin-bearing cell ... | 1975 | 168265 |
| an improved quantitative micro-complement fixation test. | the technical procedures for a simple quantitative micro-complement (c) fixation test are described. major advantages of the present technique compared with the previously described method are: a) a simple measurement of the residual hemolytic activity of c by counting the radioactivity released from 51cr-labeled sensitized sheep erythrocytes (51cr-ea); b) an increased sensitivity of the test, brought about by the use of a relatively small number of 51cr-ea per reaction volume; and c) an increas ... | 1975 | 168269 |
| predominantly t-cell infiltrate in rheumatoid synovial membranes. | lymphocytes infiltrating synovial membranes were characterized in eight patients with proliferative rheumatoid synovitis. surface immunoglobulins were studied with use of immunofluorescence, and the c3 receptor was detected by adherence of red cells coated with antibody and complement - both are b-cell markers. spontaneous rosette formation with sheep erythrocytes was used as a t-cell marker. to obtain viable lymphocytes in suspension, the villous synovium of five of these patients was digested ... | 1975 | 168488 |
| inhibition by interferon of delayed-type hypersensitivity in the mouse. | the effect of interferon on delayed-type by persensitivity to picryl chloride and sheep erythrocytes was examined in the mouse. when administered to sensitized animals on the day before or the day of challenge, tissue culture interferon inhibited both the ear swelling induced by pieryl chloride and footpad swelling induced by sheep erythrocytes. newcastle disease virus, when injected into sensitized if-1l or if-1h congenic mice a few hours before challenge, caused an inhibition of delayed-type h ... | 1975 | 168573 |
| structural changes inducted by follicle-stimulating hormone or dibutyryl cyclic amp on presumptive sertoli cells in culture. | cells isolated from testes of 20-day-old rats, maintained in primary culture in a defined medium, are shown to respond to follicle-stimulating hormone or 3:5-cyclic amp with characteristic morphological changes. no response is observed in cells treated with luteinizing hormone or 5-?amp. the cells form a mono-layer, and have been identified as presumptive sertoli cells structurally by identification of unique tight junctions in electron micrographs of the preparations, along with other ultrastru ... | 1975 | 168577 |
| correlation of survival from murine cytomegalovirus infection with spleen cell responsiveness to concanavallin a. | spleen cells from nonlethally mcmv-infected weanling and adult dba/2 mice had diminished responses to con a stimulation. in contrast, only lethal mcmv infections were associated with a complete suppression of the con a response. the immune response to srbc was depressed even in asymptomatic infections of weanling and adult mice. a marked maturation of resistance to the lethal effects of mcmv infection was found to occur during the fourth week of life. | 1975 | 168587 |
| the nasal secretion and serum antibody response of lambs following vaccination and aerosol challenge with parainfluenza 3 virus. | the nasal and serum neutralising antibody responses of lambs was compared following vaccination with live or inactivated parainfluenza 3 (pi 3) virus by either intramuscular (im) or intranasal (in) routes. nasal antibody was only detected following inoculation of live virus in or inactivated virus in freund's complete adjuvant (fca) im. immunity to aerosol challenge, as assessed by viral shedding from the nose, was conferred by (1) live virus administered by either route, (2) two im inoculations ... | 1975 | 168628 |
| ddt and related chlorinated hydrocarbon insecticides: pharmacological basis of their toxicity in mammals. | | 1975 | 168756 |
| effect of intravenous infusion of corticosteroids on blood pressure, electrolytes, and water metabolism in sheep. | acth administration (80 iu/day for 5 days), which produces hypertension and charateristic metabolic effects in sheep (38), has been compared with the effect of intravenous infusion of cortisol (5 mg/h), corticosterone (0.5 mg/h), deoxycorticosterone (50 mug/h), and 11-deoxycortisol (1 mg/h), each given singly for 5 days. further, a mixture consisting of aldosterone (3 mug/h), cortisol (5 mg/h), deoxycorticosterone (25 mug/h), corticosterone (0.5 mg/h), and 11-deoxycortisol (1 mg/h), was also in ... | 1975 | 168782 |
| newer knowledge of non-collagenous protein in dentin and cortical bone matrix. | the current state of knowledge of the composition of the ncm components of bone and dentin has been summarized at the end of the appropriate sections. it is significant that increasing interest in the chemistry of hard tissue matrices has coincided with the development and refinement of a wide range of separation techniques, resulting in the isolation of an unexpectedly large number of components. the most sophisticated techniques, such as iso-electric focusing and isotachophoresis, give rise to ... | 1975 | 168996 |
| studies on the additive effect of polymyxin b and the bactericidal activity of human serum against serratia marcescens. | two of twelve examined s. marcescens strains were promptly killed by 80% (v/v) fresh human serum (within 20 min), analogous to a serum-sensitive control strain of escherichia coli; ten strains, however, were killed by fresh serum only after extended incubation (2-4 h). the combination of therapeutically achievable concentrations of polymyxin b (range 5 to 1.25 mug/ml) and fresh, but not heat-inactivated human serum was found to exert an accelerated, additive effect against 9 of 10 'delayed seru ... | 1975 | 169108 |
| [comparitive study of phosphatase activity in the seminal plasma of various domestic animals in egypt (short communication)]. | | 1975 | 169119 |
| studies on growth hormone secretion. vii. effects of somatostatin on plasma gh, insulin, and glucagon in sheep. | to determine whether synthetic somatostatin originally isolated from sheep hypothalamus can inhibit hormone secretion in the same species, we measured plasma levels of gh, insulin, glucagon, and glucose of normal sheep under a variety of experimental conditions in the presence and absence of somatostatin infusion. an oral dose of 2.5 mg./kg. 3,5-dimethypyrazole increase plasma gh from 10.9 to 376.9 ng. per milliliter, which was suppressed by 50 per cent and 80 per cent with 0.5 and 1 mg. synthet ... | 1975 | 169176 |
| aldolase isoenzymes in liver cirrhosis and primary liver cell cancer. | the isoenzymatic pattern of aldolase was determined by immunoprecipitation with specific anti-aldolase a, b and c sera in 21 pathological liver tissues and in the sera of normals (n equals 20), liver cirrhotics (n equals 52) and hepatoma patients (n equals 22). the increase of aldolase a in primary liver cell carcinoma is not reflected in the sera of these patients, cannot be used for diagnostic purposes and is not hepatoma-specific. | 1975 | 169180 |
| the carboxylic acid groups of bovine luteinizing hormone. the effects of their modification on receptor site binding and subunit-subunit interaction. | the modification of the carboxyl groups of the subunits of bovine luteinizing hormone to neutral derivatives by carbodiimide-mediated coupling with glycine methyl ester has been studied. the modified alpha subunit, which has 8 residues of glycine methyl ester incorporated, will no longer recombine with native beta (hormone-specific) subunit, but the modified beta subunit, with 6 to 7 glycine methyl esters incorporated, will recombine with native alpha to yield a partially active hormone. derivat ... | 1975 | 169262 |
| use of the unlabeled antibody immunohistochemical technique for the detection of human antibody. | two methods have been developed which permit use of the unlabeled antibody immunohistochemical technique for detection of human antibody, without the need for immunization of humans with peroxidase. human antibody to herpes simplex virus (hsv) reacted with human cell cultures infected with hsv was the experimental system. in the first method an attempt was made to employ rabbit peroxidase-antiperoxidase (pap) soluble complexes in connectin with human antibody. this was done by sequential additio ... | 1975 | 169304 |
| cyclic amp production in isolated rat seminiferous tubule cell preparations: a potential in vitro assay for follicle stimulating hormone. | | 1975 | 169451 |
| [prenatal infections and nervous system (author's transl)]. | | 1975 | 169523 |
| ultrastructural changes in the placenta of the ewe following foetal infusion of cortisol. | the placental changes which followed continuous infusion of cortisol into the sheep foetus in the later stages of gestation were, like the hormonal changes, broadly similar to those of spontaneous parturition. there was, however, a premature separation of foetal and maternal tissues in certain areas of the placental cotyledons, and this separation appeared to protect the foetal epithelium from the degenerative changes which normally take place in the short space of time between the birth of the ... | 1975 | 169543 |
| a biochemical hypothesis to explain the mechanism of luteal regression. | it seems likely that luteal regression may involve a direct biochemical action of prostaglandin f2alpha (pgf2alpha) on the luteal cell since there are now several reports that pgf2alpha can directly inhibit steroidogenesis in vitro. however, the mechanism of such an action of pgf2alpha remains obscure. this article initially reviews the central role of adenosine 3,i5i-mono-phosphate (c-amp) in initiating and maintaining the structural and functional changes occurring on luteinisation. a mechanis ... | 1975 | 169550 |
| antibodies to parainfluenza 3 virus in cattle, sheep and goats from northern nigeria. | | 1975 | 169621 |
| [bovine viruses and methods for their detection]. | | 1975 | 169627 |
| [damaging effect of 2 simian viruses on mammalian cell chromosomes]. | a green monkey myxovirus (sv5) causes chromosome breaks in embryonal diploid fibroblasts of man, cotton rats, striped hairy-footed hamster, and in cells of one heteroploid line of newborn lamb kidney. adenovirus sv15 is mutagenic for all cultures under study (diploid strains of human and cotton rat embryo fibroblasts and three continuous kidney cell lines from newborn lambs). the mutagenic activity of these viruses may be manifested without their undergoing a complete cycle of replication. | 1975 | 169630 |
| [morphological manifestations of the intracellular toxic effect of microorganisms of the ornithosis-lymphogranuloma-trachoma group]. | interactions of the causative agents of meningopneumonia and ovine abortion with pulmonary macrophages in experimental infection in white mice were studied by histological, immunofluorescent and electron microscopic methods. the causative agent of meningopneumonia did not multiply in colonies and caused toxic lesions in the cells and formed cytoplasmic oxiphilic inclusion bodies. being the product of cell degeneration, these oxiphilic inclusion bodies were conducive to long-term survival of the ... | 1975 | 169631 |
| influence of bordetella pertussis and bacterial endotoxins on the immunological reactivity of germfree mice. | as compared to specifically pathogen-free nmri mice, in principle, the immunological reactivity of germfree mice of the same strain and age was not found to be reduced. this is documented by the cellular kinetics of the primary immune responses, evoked by the intraperitoneal (i.p.) injection of either a "saturated" dose of 4 times 10(8) sheep erythrocytes (se) or the simultaneous injection of 4 times 10(8) se and 3 times 10(9) killed bordetella pertussis organisms (po). thereby, adjuvancy of po ... | 1975 | 169652 |
| primary aldosteronism. a study in contrasts. | two patient with primary aldosteronism, one with a solitary adrenal adenoma and the other with bilateral nodular hyperplasia, are described. both patients showed the classic features of primary aldosteronism in electrolyte and hormone patterns, but there were important differences in the biochemistry of their excised adrenal tissue. in addition, the injection of plasma from the patient with bilateral adrenal hyperplasia into the sheep's transplanted adrenal gland elicited a definite aldosterone ... | 1975 | 169691 |
| [ultrastructure and histochemistry of the ependyma in the iii. ventricle of domestic ruminants]. | | 1975 | 169714 |
| the chemotaxis of selected cell types to connective tissue degradation products. | because rheumatoid inflammation is associated with the presence of large numbers of leukocytes in joint effusions, the question of whether enzymatic splitting of collagen and fibrin can lead to generation of chemotactic factors was investigated. fibrinogen was purified from the plasma of four different species, and the homogeneity of the preparations was established by physicochemical and immunologic techniques. fibrin was prepared and then lysed with plasmin to obtain fibrin degradation product ... | 1975 | 169719 |
| bluetongue in sheep and goats. | a description is given of the symptomatology, pathology and pathogenesis of bluetongue in sheep and goats. the economic significance of the disease in south africa is discussed. | 1975 | 169785 |
| bluetongue: the disease in cattle. | most researchers in south africa found that although bt virus could be isolated from apparently healthy cattle and from inoculated cattle the virus did not produce overt clinical disease in cattle. however, when epizootics were reported outside africa, clinical signs were observed in cattle in israel, palestine, syria, portugal, and spain. most natural bt infections in cattle in the united states do not result in overt clinical signs. however, in certain infected herds, approximately 5% of the c ... | 1975 | 169786 |
| bluetongue-like disease of deer. | a comparison has been made of the disease produced in white-tailed deer by the viruses of epizootic haemorrhagic disease and bluetongue. the similar nature of these diseases in deer and of some of the viral properties has been described. although these two viruses are considered to be distinct, it is possible by employing an unnatural procedure to produce antibody which will demonstrate a minor antigenic component common to both viruses. biological features that differ between the two viruses ha ... | 1975 | 169787 |
| ibaraki disease and its relationship to bluetongue. | ibaraki disease, an epizootic disease of cattle in japan resembling bluetongue, is characterized by fever and lesions affecting the mucous membranes, the skin, the musculature and vascular system. degeneration of striated muscular tissue is observed in the oesophagus, larynx, pharynx, tongue and the skeletal muscles. oedema and haemorrhage are marked in the mouth, lips, abomasum, around the coronets, etc., and are occasionally followed by degeneration of the epithelium leading to erosions or ulc ... | 1975 | 169788 |
| serological methods in the diagnosis of bluetongue. | the viral antibodies in the serum of cattle, sheep and deer are not detectable in the ordinary direct cf test. we have shown that the so-called "non complement-fixing" viral antibodies in the serum of these animal species can be demonstrated by the mdcf test. the mdcf test, as well as the micro agp test, are group reactive, with all bt isolates studied. however, it is possible with these tests to differentiate antigenically bt virus from ehd virus. the fat was also useful in differentiating bt v ... | 1975 | 169789 |
| the comparative sensitivity of sheep and chicken embryos to bluetongue virus and observations on viraemia in experimentally infected sheep. | the virus titre in sheep blood samples received from bt-suspected cases in the field was assayed in sheep and in chicken embryos. these infected blood samples represented 3 different bt virus types: 4, 10 and 16. three identical experiments were performed, one with each of the 3 different virus types. ten-fold dilutions of the infected blood samples were prepared and 1 ml of each blood dilution was inoculated iv into series of 10 to 12-month old susceptible sheep; at the same time 0.1 ml of each ... | 1975 | 169790 |
| the epizootiology of bluetongue: the african situation. | bluetongue virus is transmitted biologically by various species of culicoides, notably c. pallidipennis and c. variipennis. factors such as rainfall, temperature and relative altitude, which influence the breeding of the insect vectors also govern the incidence and distribution of the disease. the host range of bluetongue virus includes sheep, cattle, goats and various antelopes. many other, as yet unidentified hosts could perhaps harbour the virus and influence the epizootiology of the disease. ... | 1975 | 169791 |
| bluetongue in cyprus. | | 1975 | 169792 |
| epizootiology of bluetongue: the situation in the united states of america. | bluetongue was first reported in the united states in 1948 in sheep in texas. the virus has now been isolated from sheep in 19 states. when the disease first occurs in a flock, the morbidity may reach 50 to 75% and mortality 20 to 50%. in subsequent years, the morbidity may be only 1 to 2% with very few deaths. difference in breed susceptibility has not been observed. natural bluetongue infection has not been observed in angora or dairy goats. bluetongue virus was first isolated from cattle, in ... | 1975 | 169793 |
| the control of bluetongue in an enzootic situation. | on account of the wide host range of bluetongue virus and its biological transmission by insects, control of the disease in an enzootic situation is based primarily on the active immunisation of susceptible animals as well as on the prevention of contact between the insect vectors and the susceptible hosts. in spite of their unquestionable value, the egg attenuated vaccines which are currently employed for prophylactic immunisation, have certain shortcomings. the existence of 16 known serotypes ... | 1975 | 169794 |
| certification of ruminants, semen, and ova for freedom from bluetongue virus. | | 1975 | 169795 |
| bluetongue certification -- australian policy. | australian quarantine policies with respect to bt are based on regarding this disease as one of high risk and major potential economic importance to our ruminant population. there are deficiencies in our knowledge of world distribution, epidemiology and pathogenesis. there may be unknown vectors and unsuspected animal reservoir hosts. the international distribution of bt could be extending through the movements of insects or cattle. if introduced into australia, the cattle and sheep populations ... | 1975 | 169796 |
| potential vectors of bluetongue in australia. | | 1975 | 169797 |
| control of bluetongue in an epizootic situation: australian plans. | epizootics of bt outside africa have occurred in the middle east, indian subcontinent, spain and portugal, and the united states of america. the disease has only been eradicated from a major region once, this being spain and portugal in 1956-60 when it was achieved by quarantine, compulsory vaccination and slaughter of some infected animals. because of the serious economic effect that bt would have on the australian sheep industry the policy in this country is to attempt eradication, if at all f ... | 1975 | 169798 |
| t-lymphocyte cell lines derived from patients with acute lymphoblastic leukemia. | several lymphoid cell lines with thymus-dependent lymphocyte (t-cell) characteristics have been established from 2 patients with acute lymphoblastic leukemia (all). these cell lines are considered to be leukemic t-cells on the basis of their abnormal chromosome constitution, growth in heterologous animals, ability to form rosettes with sheep red blood cells and the absence of immunoglobulin production, and destruction by antithymus cell sera. sera from patients with leukemia did not react with t ... | 1975 | 169811 |
| comparisons of surface markers on herpesvirus-associated lymphoid cells of nonhuman primates and established human lymphoid cell lines. | herpesvirus saimiri (hvs)-owl monkey lymphoid cells were found to have high levels of surface receptor for sheep erythrocytes and erythrocytes of 3 other species. these hvs-lymphoid cells lacked a receptor for modified complement. lymphoid cells of one hvs-owl monkey line showed evidence for the presence of surface immunofluorescent staining with anti-kappa chain serum. cells of an established hvs-marmoset lymphoid line had similar surface markers. of 4 established human lymphoid cell lines, all ... | 1975 | 169815 |
| the binding of adenosine-3',5'-monophosphate by messenger ribonucleoprotein-like particles. | | 1975 | 169853 |
| thyrotropin releasing hormone (trh): apparent receptor binding in rat brain membranes. | thyrotropin releasing hormone (trh) binds to membranes of rat brain tissue via high- and low-affinity binding components. the high-affinity binding of trh to brain membranes resembles binding to pituitary membranes in terms of its affinity and specificity for most peptides. in equilibrium studies, the affinity and specificity for most peptides. in equilibrium studies, the dissociation constant for high-affinity binding to brain membranes is about 50 dissociation constant for high-affinity bindin ... | 1975 | 169955 |
| [nitrosoguanidine-induced attenuated clostridium perfringens type a mutant in gas gangrene]. | a fully virulent classical type a strain of clostridium perfringens was treated during its logarithmic growth phase with 100 mug/ml of n-méthyl-n'-nitro-n-nitrosoguanidine, the bacteria being exposed to the mutagen for 30 min at 37 degrees c in a phosphate buffer adjusted to ph 6.2; after treatment the suspension was streaked on sheep blood agar plates, and colonies that showed an alteration in the theta-hemolysis pattern were selected for isolation. the virulence of two mutants, thus altered in ... | 1975 | 169977 |
| [effect of acth on extravascular protein circulation in the lymph and blood of rams]. | | 1975 | 169991 |
| demonstration of a specific receptor for prolactin in porcine granulosa cells. | porcine granulosa cells and subcellular fractions from these cells have been shown to have a specific receptor for ovine prolactin (oprl). ovine growth hormone demonstrated 7% of the potency of oprl in displacing 125i-oprl from its binding site; fsh, tsh, lh, insulin and acth showed negligible cross-reactivity. scatchard analysis of the displacement curves suggested that 125i-oprl has a high affinity for its receptor with a dissociation constant (kd) for the granulosa cell-receptor of 7.4-7.7 ti ... | 1975 | 170061 |