| some characteristics of sulphate uptake into synaptosomes. | incorporation of na235so4 by ovine brain ficoll-prepared synaptosomes were studied as a function of time, temperature and substrate concentration. the rate of uptake obeyed michaelis-menten kinetics and apparent km value of 4.4 mm na2so4 was determined. in the presence of p-hydroxymercuribenzoate a reduction in sulphate uptake was noted which suggests that thiol groups may possibly be implicated in the uptake mechanism. | 1979 | 157010 |
| [the development of the omental bursa in sheep and its significance for the topography of the abdominal cavity]. | | 1979 | 157082 |
| ultrastructural observations on the tapetum lucidum fibrosum. | | 1979 | 157086 |
| a surgical technique for the collection of cervical mucus in the ewe. | a technique for collecting cervical mucus in ewes is described. by a surgical procedure, the cervix was fixed to the ventral abdominal wall to enable mucus to be collected continuously into a container attached to the ewe. mucus was collected successfully by this method for up to 14 months. | 1979 | 157128 |
| [effect of dietary protein levels on the amount of blood free amino acids in lambs]. | growing lambs were fed increasing amounts of nitrogenous matter (12 to 20 per 100 on dry matter basis). free amino acid and urea levels were measured in blood of 37 kg lambs. when crude protein content of diets exceeded 16 per 100, the catabolism of several essential amino acids increased. methionine, lysine and histidine seemed to be limiting for growing lambs. | 1978 | 157208 |
| [central origin on the excito-motric action of morphine on intestine]. | in ewew fitted with a cerebro-ventricular cannula and equipped with extra-cellular bipolar electrodes on the antrum and proximal small intestine, an intraventricular injection of morphine at a dose (40 micrograms/kg) ineffective peripherally was followed within 1 min by an increased spike activity of the duodenum without disruption of the occurrence of migrating myoelectric complexes. this effect was paralleled by a reduction of antral motility and abolished by small intraventricular doses of na ... | 1978 | 157214 |
| quantitative assessment of the effects of platelet depletion in the autologous phase of nephrotoxic serum nephritis. | the effects of platelet depletion with antibody have been studied in two models of the autologous phase of nephrotoxic nephritis in the rabbit. in the 'telescoped' model (animals pre-immunized to sheep igg injected with sheep nephrotoxic antibody), platelet depletion did not alter intraglomerular fibrin deposition or evidence of glomerular damage, but did significantly reduce proteinuria during the first 3 days of the 5 day experiment. in the 'passive' model (animals injected with hyperimmune ra ... | 1979 | 157239 |
| cobalt induced changes in immune response and adenosine triphosphatase activities in rats. | the immuno-biochemical effects of cobaltous chloride in rats receiving iron-sufficient and deficient diets were investigated. rats receiving 100 ppm or more cobalt showed a significant reduction in thymus and body weights along with a marked decrease in hemoglobin, hematocrit, sheep agglutinins and plaque forming cells. these effects were more pronounced in rats receiving cobalt mixed with iron-deficient diet than those fed on iron-sufficient diet. the na+-k+ and mitochondrial (oligomycin-sensit ... | 1979 | 157363 |
| metabolism of crufomate (4-tert-butyl-2-chlorophenyl methyl methylphosphoramidate) administered topically to a sheep. | a sheep dosed topically with 14c-crufomate (4-tert-butyl-2-chlorophenyl methyl methylphosphoramidate) excreted 45.5% of the 14c dose in the urine within 9 days. the feces contained 1.2% and the carcass 40.4% (this included the 37.7% of the dose remaining on the skin in the dosing area) of the dose. at sacrifice, the fat, liver, kidney, lung, and skin (where the dose was applied) contained the highest concentrations of 14c. fourteen urinary metabolites were isolated and characterized by mass spec ... | 1979 | 157364 |
| efficacy of selected antimicrobial agents in treating diarrheal disease in neonatal lambs. | | 1979 | 157584 |
| efficacy of oxfendazole against natural infestations of nematodes and cestodes in sheep in egypt. | oxfendazole liquid suspension (systamex; wellcome) was administered orally at the dose of 4.5 mg per kg to 800 indigenous egyptian sheep clinically affected with dictyocaulus filaria, moniezia expansa, haemonchus contortus, ostertagia circumcincta, nematodirus spp, trichostrongylus axei, cooperia curticei, trichuris ovis and oesophagostomum spp. a 100 per cent clearance was recorded for all parasites with the exception of t ovis which were markedly reduced in number. | 1979 | 157586 |
| turnover rates of hexokinase i, phosphofructokinase, pyruvate kinase and creatine kinase in slow-twitch soleus muscle and heart of the rabbit. | hexokinase i was purified from rabbit heart to a specific activity of 70 u/mg protein. the purified enzyme was electrophoretically homogeneous with an apparent molecular weight of 102,000. purified immunoglobulins from sheep were used to titrate the percentage of hexokinase i in various tissues of the rabbit. precipitating antibodies from sheep were also prepared against rabbit muscle mm-creatine kinase, phosphofructokinase and pyruvate kinase. apparent turnover rates of these phosphotransferase ... | 1979 | 157876 |
| the n-terminal amino acid sequence of sheep heart phosphofructokinase [proceedings]. | | 1979 | 157899 |
| aberrant secondary antibody responses to sheep erythrocytes in rabbits with experimental syphilis. | rabbits infected with treponema pallidum have strikingly depressed in vivo immunoglobulin g responses to sheep erythrocytes. to gain further insight into the nature of this suppression, the immune responses of splenic and peripheral blood lymphocytes from infected rabbits to sheep erythrocytes were studied in vitro. spleen cells from rabbits that had been sensitized with sheep erythrocytes during active syphilis had greatly decreased immunoglobulin m and g responses after in vitro incubation wit ... | 1979 | 157977 |
| alterations of the immune response associated with chronic experimental leishmaniasis. | balb/c mice infected with leishmania mexicana developed a chronic infection usually accompanied by the appearance of metastatic lesions. throughout the 20 weeks of observation, infected mice ;howed an impairment in both in vivo delayed hypersensitivity response and in vitro lymphocyte reactivity to leishmanial antigen. four to 8 weeks after inoculation infected mice displayed a transitory enhancement of spleen cell responses to phytohemagglutinin p, concanavalin a, and lipopolysaccharide. at the ... | 1979 | 157979 |
| [epzootiology, course and treatment of fascioliasis in sheep]. | | 1979 | 158253 |
| the human mixed lymphocyte reaction responder and stimulator capacities of highly purified t- and non-t cells and the role of monocytes. | e-rosette sedimentation with aet treated sheep red blood cells and human lymphocytes provieded a source of highly purified t- and non-t cells. together with unseparated cells these were tested for responder and stimulator capacities in the mixed lymphocyte reaction, and it was found that the non-t cells were weak, but consistent responders only when t cells were present as stimulators. on the other hand, t-t combinations always exhibited weak proliferation demonstrating that t cells possess stim ... | 1979 | 158284 |
| digoxin antibodies a remedy for life threatening digitalis toxicity. | | 1979 | 158583 |
| [the mechanical properties of callus in fractures treated by nailing or plating: an experimental study (author's transl)]. | twelve sheep were used in an experimental study on bone healing. the first metatarsal was fractured and fixed either by plating without compression or by intramedullary nailing. three months later, the animals were sacrificed, the fractured bone removed and the mechanical properties of the callus were assessed by resistance to rupture, tangential strain measurement, the energy required for rupture, module of elasticity and the moment of inertia. it was concluded that callus was superior quantita ... | 1979 | 158812 |
| post-mortem electrical stimulation of muscle and its effects on sarcoplasmic reticulum adenosine triphosphatase. | sarcoplasmic reticulum (sr) was isolated from control muscles and from muscles which had been subjected to short-term post-mortem electrical stimulation. both preparations had similar protein compositions but the sr from electrically stimulated muscle had a lower 'extra' atpase activity. the ability of the sr preparations from electrically stimulated muscles to accumulate ca2+ was about the same as the controls. there was, therefore, an apparently greater efficiency of ca2+ transport in the isol ... | 1979 | 159039 |
| [cumulative effect of microwaves at 2450 mhz on the immune response of the mouse]. | | 1978 | 159103 |
| the cardiac hypertrophy process. analyses of factors determining pathological vs. physiological development. | | 1979 | 159142 |
| ontogeny of cells involved in the suppressor circuit of the immune response. | some macrophage (m phi) cell surface structures which bind t cell-derived factors remain intact after the m phi are killed by heating at 56 degrees c (but not 72 degrees c) for 45 min. as a result, appropriately killed m phi (hk m phi) can act as competitive antagonists for those m phi functions which are involved in binding and active presentation of t cell-derived regulatory signals. by blocking the transmission of these signals with hk m phi, we have found that the spleens of newborn mice con ... | 1979 | 159184 |
| role of environment in the development of "natural" hemagglutinins in minnesota miniature swine. | "natural" hemagglutinin titers against a panel of fixed erythrocyte antigens were determined for groups of minnesota miniature swine reared conventionally, in a specific pathogen-free facility, and in germfree isolators. sera were assayed for hemagglutination (ha) titers by the microtiter method against 12 species of erythrocytes stabilized by treatment with pyruvic aldehyde and formaldehyde. these erythrocytes were stable for up to 2 years and gave slightly enhanced ha titers as compared to fre ... | 1979 | 159262 |
| sex-related immunocompetence of balb/c mice. i. study of immunologic responsiveness of neonatal, weanling, and young adult mice. | the responses of lymphoid cells from the thymus, lymph nodes, and spleen of male and female balb/c mice were evaluated to determine if sex-related variations in immune expression could be found. immunologic assays used included blastogenic responses to mitogens, mixed lymphocyte responses, and direct and indirect measurement of plaque-forming cells against soluble and particulate antigens. the results indicated that responses of spleen cells from young adult female mice were higher than those of ... | 1979 | 159320 |
| delayed-type hypersensitivity (dth) in bcg-sensitized mice i. lack of suppressor t cell activity on dth to sheep red blood cells. | mice pretreated with an intravenous (i.v.) injection of bcg (bcg-sensitized mice) and then immunized intravenously with a high dose (10(8)--10(9)) of sheep red blood cells (srbc) 2 weeks later developed strong delayed-type hypersensitivity (dth) to srbc, as in mice pretreated with cyclophosphamide (cy) (cy-treated mice) and then immunized with srbc 2 days later; normal mice given the same dose of srbc did not show such dth. the mechanism of this strong dth to srbc which developed in bcg-sensitiz ... | 1979 | 159397 |
| [comparative morphological studies of the structure of the articular disk of the temporomandibular joint]. | articular disks (da) of mandibular articulations of several types of animals of different ages and both sexes (herbivora, carnivora, rodents and omnivora) were studied. comparative macroscopy emphasized similarities with the da of humans and other omnivora, as well as some peculiarities. da is ellyptical in herbivora; its upper surface is divided into two facets by a transversal crest. da is pinkish and square in carnivora; its posterior part is lacking. da is half-moonish and white-nacreous in ... | 1979 | 159402 |
| bacterial lipopolysaccharide activates suppressor b lymphocytes. | lipopolysaccharide (lps) extracted from the outer cell wall of gram-negative bacteria modulates the immune response in vivo and in vitro. depending on the experimental conditions, it may enhance or inhibit the production of humoral antibody. the pathway by which lps suppresses antibody production is examined in this study. c57bl/6 spleen cells incubated with lps (greater than 10 micrograms/ml) not only fail to produce antibody to sheep erythrocytes in vitro but also, when transferred 24 hr after ... | 1979 | 159461 |
| [study of the allogenic reactivity and suppression function of lymphocytes, in rheumatoid polyarthritis treated with cold salts, in mixed lymphocyte cultures]. | in a group of 30 rheumatoid polyarthritis treated with gold salts, a determination of the t lymphocytes (sheep red cells) furnished in percentage normal values, and in absolute value a normal average value, with, however, a low level of t lymphocytes. in autologous lymphocyte cultures no spontaneous increase of dna synthesis was registered. the allogenic response was normal, and in mixed culture with the addition of a third type of cells, a discrete specific suppressive activity appeared. | 1979 | 159488 |
| [the papillary body of the proventricular mucous membrane in sheep and goats]. | | 1979 | 159644 |
| characterization of mg2+-atpase from sheep kidney medulla: purification. | | 1979 | 159664 |
| [mechanism of action of t cell factors regulating antibody formation]. | while the induction of antibody synthesis depends on antigen specific t cell factors, its magnitude is under control of non antigen specific t cell factors. in this respect, trf ("t cell replacing factor") amplifies antibody responses while ibf ("immunoglobulin binding factor") acts as a suppressor factor. using cultures of spleen cells from nude mice, we show that both factors act sequentially, influencing the final differenciation of b cells to antibody producing cells. we have no evidence of ... | 1979 | 159750 |
| suppression of secondary plaque-forming cell responses by rat splenic adherent cells: evidence for dependence on prostaglandin production. | | 1979 | 159783 |
| immunosuppressive effect of soluble e receptors in uremic serum. | | 1979 | 159794 |
| immune responses during pregnancy. evidence of suppressor cells for splenic antibody response. | the primary igm antibody response to sheep erythrocytes in vivo as well as in vitro is markedly decreased in the spleen cells of pregnant mice, compared to age-matched female controls. decreased antibody synthesis appears to be mediated by nonspecific suppressor cells, because the addition of pregnant spleen cells to the normal spleen cell cultures causes a significant suppression of plaque-forming-cell responses of the normal spleen cells. suppressor cell activity was not observed in lymph node ... | 1979 | 159935 |
| [effective agent]. | | 1979 | 160113 |
| [stock overwintering goes on]. | | 1979 | 160116 |
| [control of monieziasis and gastrointestinal and pulmonary threadworms in sheep with fenbendazole]. | | 1979 | 160140 |
| microfluorometric study of glycolytic enzymes in histologically defined areas of the sheep uterus and placentomes during pregnancy. | | 1979 | 160251 |
| [suppression of delayed hypersensitivity in mice receiving a massive dose of xenogeneic erythrocytes]. | the injection of 6x109 sheep red blood cells to mice suppresses delayed-type hypersensitivity (dth) in situ and activates spleen cells which prevent sensitization of recipients. preliminary thymectomy of donors and the treatment of cell suspensions with anti-t-globulin abolish suppression of dth. pretreatment of mice with low doses of cyclophosphamide (cy) enhances antibody formation and dth. higher doses of cy increase the dth reaction but inhibit antibody formation. the data obtained allow to ... | 1979 | 160253 |
| peritoneal exudate t lymphocytes with specificity to sheep red blood cells. iii. high dose of antigen induces suppressor t cells which influence the appearance in exudates of effector t cells for delayed-type hypersensitivity and helper t cells for humoral immune responses. | antisera produced in rabbits against adherent cells of rat alveolar or peritoneal lavage fluid (anti-rat alveolar macrophage sera, arams, or anti-rat peritoneal macrophage sera, arpms) were used to detect antigenic differences between alveolar (am) and peritoneal (pm) macrophages in an indirect membrane immunofluorescence (imf) test. of all sera tested, the imf titres were higher with cells of that population which was used for immunization. these differences were found before and after exhausti ... | 1979 | 160395 |
| therapeutic aspects. immunosuppression in established humoral responses. | | 1979 | 160421 |
| urease activity in the contents and tissues of the sheep, pig and chicken gastrointestinal apparatus. | urease activity, expressed as mg n-nh3/g dry weight per 30 min at 25 degrees c, was determined in the various parts of the sheep, chicken and pig digestive apparatus. the results were as follows. sheep: contents--rumen 1.25"/-0.09, reticulum 0.78+/-0.02, omasum 0.44+/-0.02, abomasum 0.002+/-0.001, duodenum 0.003+/-0.001, jejunum 0.18+/-0.03, ileum 0.42+/-0.03, caecum 1.34+/-0.11, colon 0.76+/-0.08, walls-rumen 0.88+/-0.16, reticulum 0.38+/-0.04, omasum 0.11+/-0.02, abomasum 0.01+/-0.002, ileum 0 ... | 1979 | 160576 |
| endogenous urea secretion into the sheep gastrointestinal tract. | urea turnover and the proportion of endogenous urea secreted and excreted in the saliva, the bile, the pancreatic juice and the urine and directly across the wall of the digestive tract was studied in 6 experiments, after a single i.v. dose of labelled 15n, in two adult sheep weighing 49 and 50 kg, with permanent biliary and pancreatic fistulus and with an exteriorized right parotid duct. it was found that, of the total amount of endogenous urea secreted into the animals' digestive tract (0.2694 ... | 1979 | 160577 |
| characteristics of an electromagnetic flow meter specially built to measure intestinal flow in sheep. | | 1979 | 161155 |
| fine structure of principal cells in the initial segment of the epididymal duct in the ram. | | 1979 | 161482 |
| comparison of the effects of a non-steroidal anti-inflammatory agent, an immunosuppressive, a corticosteroid and an immunomodulator on various immunological and non-immunological inflammatory experimental models. | the effects of a non-steroidal anti-inflammatory agent, phenylbutazone, a corticosteroid, desonide, an immunosuppressive, cyclophosphamide and an immunomodulator, levamisole on a number of experimental inflammatory models were compared. compounds were first tested in carrageenin-induced pleurisy as a non-immune acute inflammation, then in passive skin anaphylaxis and reversed passive arthus oedema in the rat as models of humoral immunity. finally the compounds were investigated in various delaye ... | 1979 | 161700 |
| polyclonal antibody secretion induced in human mixed lymphocyte cultures. | in mixed leucocyte culture (mlc), using human spleen cells or thoracic duct lymphocytes, antibody secretion was induced, measured as plaque-forming cells (pfc) in a haemolysis-in-gel assay with fluorescein isothiocyanate (fitc)-coupled sheep erythrocytes (srbc) as targets. peak antibody secretion was seen on day 5. using protein-a-coupled srbc as targets and developing antisera, antibody secretion in mlc was found to be of igm, igg and iga type. there was no correlation between the number of pfc ... | 1979 | 161818 |
| [total serum protein and the protein spectrum of sheep and lambs after experimental percutaneous invasion by bunostomum trigonosephalum]. | serum proteins and their fractions in sheep and lambs following experimental b. trigonocephalum percutaneous invasion were investigated. it was established that total serum protein and albumen reduction as well as beta- and gamma-globulin enhancement occur following the invasion. these changes were observed on the 50th day post invasion, but they were most pronounced after clinical symptoms of bunostomosis appeared. the albumen-globulin coefficient was considerably reduced post invasion. all cha ... | 1979 | 161828 |
| biological activity of the slime and endotoxin of the periodontopathic organism eikenella corrodens. | a partially purified water-soluble slime extract was obtained from two strains of the oral pathogen eikenella corrodens, designated cs10 a and cs10 b. endotoxin was also isolated from this organism by the phenol-water extraction procedure. assays including the local shwartzman skin reactivity, chicken embryo lethality, limulus lysate clotting, spleen cell mitogenicity, and immune adjuvancy were used to test the biological properties of these two bacterial extracts. in each of these assay systems ... | 1979 | 161911 |
| cytotoxic and proliferative lymphocyte responses to allogeneic and xenogeneic antigens in vitro. | in vitro lymphoproliferative responses to foreign histocompatibility antigens are phylogenetically restricted. responses occur most readily to allogeneic or closely related xenogeneic leucocytes, but not to unrelated xenogeneic cells. specific cytotoxic t cell responses to foreign histocompatibility antigens show the same phylogenetic restriction. this lack of xenoreactivity is not due to a lack of precursor cells for the xenoantigens; guinea-pig lymphocytes, although normally unresponsive to mo ... | 1979 | 161967 |
| the regulation of the placental blood flows. | | 1979 | 162294 |
| inhibition of the humoral response by spleen cells from cyclophosphamide-treated mice. | spleen cells obtained from mice injected with cyclophosphamide (200 mg/kg body weight) suppressed the secondary igg antibody response of memory cells to a t-dependent antigen, dnp-hgg, in millipore diffusion chambers. significant suppression (greater than 50%) was found from 5 to 14 days following cyclophosphamide treatment, with peak suppression (86%) on day 7. the primary igm antibody response to dnp-ficoll, a t-independent antigen, was not suppressed by these cells. in contrast, suppression w ... | 1979 | 162449 |
| utilization of 15n-urea administered into the sheep small intestine. | the retention and excretion of intrajejunally administered 15n-urea was studied in four experiments on two sheep with a permanently fistulated small intestine. in the first 7 days after the administration of 2 g 15n-urea, 18.26% was excreted in the faeces and 19% in the urine; 62.74% was retained in the organism. urinary excretion took place mainly on the first day and from the 3rd to the 7th day no 15n was present in the urine. the rate of 15n excretion in the faeces was roughly the same for th ... | 1977 | 162631 |
| the response of peripheral lymphocytes of nude mice and leucopenic hybrids to antigen and lymphokine challenge. | | 1978 | 162755 |
| ultrastructural studies of parallel tubular arrays in human lymphocytes. | parallel tubular inclusions were found in peripheral blood lymphocytes from 18 patients with various hematologic disorders, primarily lymphoproliferative processes, and 1 apparently healthy individual. the inclusions varied in size from 1000 to 6000 a and were usually membrane bounded. the microtubule-like structures comprising the inclusions ranged in size from 150 to 300 a and were packed in wall-to-wall contact with each other. dense amorphous material and small dark crystalloids were frequen ... | 1975 | 162823 |
| the clearance of acth from the plasma of adult and fetal sheep. | the disappearance of 125-i-acth from the circulation of 4 pregnant and fetal sheep has been followed after a single injection to the ewe or fetus. the mean metabolic clearance rate for the fetus and the ewe was 55 and 34 ml/min/kg respectively, giving a half-life in each case of about 1 min. the higher fetal than maternal arterial plasma acth concentration has been ascribed to a higher rate of secretion rather than a reduced rate of clearance compared with the ewe. there was no evidence of place ... | 1975 | 162880 |
| assay of cellular steroid receptors using steroid antibodies. | | 1975 | 163000 |
| effect of polymyxin b on liposomal membranes derived from escherichia coli lipids. | the specificity of the action of polymyxin b was studied using liposomes as a model membrane system. liposomes prepared from total lipids of gram-negative bacteria escherichia coli, a mixture of purified e. coli phosphatidylethanolamine and cardiolipin and a mixture of phosphatidylethanolamine and phosphatidylglycerol, were extemely sensitive to polymyxin while those prepared from lipids of gram-positive bacteria streptococcus sanguis, lipids of sheep erythrocyte membranes, mixtures of egg lecit ... | 1975 | 163098 |
| characterization of a serum inhibitor of mlc reactions. iii. specificity: hl-a-related antibodies. | | 1975 | 163145 |
| determination of diphenylhydantoin in human serum by spin immunoassay. | a spinn immunoassay for diphenylhydantoin is reported, which appears to give an accurate and precise estimate of serum diphenylhydantoin concentrations, as judged by the disappearance of [14c]diphenylhydantoin from the serum of a rabbit. the assay also appears to be a reliable technique for routine diphenylhydantoin determinations, as judged from our experience with 28 patients. serum diphenylhydantoin concentrations in the range of 1.0-50.0 mg/liter are easily determined on a 50-mul sample. exc ... | 1975 | 163156 |
| functional evaluation of lung mitochondria. | activity of lung mitochondria was studied with a preparation of isolated mitochondria. this was correlated with responses of the isolated perfused lung as determined from surface fluorescence measurements and tissue redox couples. lung mitochondria demonstrated substrate oxidation, respiratory control, and caplus plus activation of alpha-glycerophosphate dehydrogenase. in response to oxidative inhibitors, the isolated lung showed increased surface fluorescence and increased tissue ratios of redo ... | 1975 | 163171 |
| [occurence of the maedi disease in sheep slaughtered at the frankfurt/main abbatoirs]. | | 1975 | 163180 |
| antigenic response to topically applied proteins. | six different proteins varying widely in molecular weight, ribonuclease, lysostaphin, ovalbumin, penicillinase, collagenase, and varidase were tested for their ability to induce circulating antibody formation in rabbits after repeated topical application of the proteins in a water-soluble gel vehicle. after a 12-week exposure period, significant hemagglutinin titers were noted in rabbits treated with ovalbumin, lysostaphin, or ribonuclease; markedly elevated, passive cutaneous anaphylaxis-reacti ... | 1975 | 163218 |
| interactions of adrenocorticotropic hormone with its adrenal receptors. degradation of acth-1-24 and acth-11-24. | crude membranes (20,000 times g pellet) prepared from human, rat, and ovine adrenals bind 125-i-corticotropin-(1-24)-tetracosapeptide (125-i-acth-1-24) and degrade unbound hormone. the degradation is dependent on temperature and the concentration of membrane proteins. the degradation of 125-i-[9-tryptophan(o-nitrophenylsulfenyl)]-corticotropin-(1-24)-tetracosapeptide (125-i-nps-acth-1-24) is similar to 125-i-acth-1-24, but that of 125-i-corticotropin-(11-24)-tetradecapeptide (125-i-acth-1-24 is ... | 1975 | 163255 |
| modulation of in vivo antibody responses by cholera toxin. | treatment of mice with an exotoxin (0.01 mug to 1.0 mug) purified from vibrio cholerae culture filtrates markedly influenced the immune response to sheep erythrocytes (srbc) and the escherichia coli lipopolysaccharide (lps). simultaneous administration of the toxin (ct) with antigen resulted in a delayed appearance of antibody plaque-forming cells (pfc) during the first few days after immunization, followed by a marked enhancement of both igm and igg pfc. the secondary immune response to srbc wa ... | 1975 | 163279 |
| role of foetal adrenocorticotrophin during parturition in sheep. | | 1975 | 163441 |
| [ethiology of infectious enterotexemia of sheep]. | | 1975 | 163520 |
| a mixed-immunoglobulin rosette technique for detection of antibody to feline oncornavirus-associated cell membrane antigen. | a mixed-immunoglobulin rosette technique has been developed for the detection of antibodies to feline oncornavirus-associated cell membrane antigens. lymphoblastoid cells infected with feline leukemia virus were incubated with test sera and then fixed in paraformaldehyde. they were then exposed to a rabbit anti-cat immunoglobulin g serum. antigen-antibody reactions were detected by mixing the cells with sheep erythrocytes sensitized with cat anti-sheep red blood cell serum; the presence of cat a ... | 1975 | 163696 |
| inhibition by iodide of the activation of the thyroid cyclic 3',5'-amp system. | the action of iodide on the cyclic amp system of dog thyroid slices has been studied. iodide inhibits the enhancement of cyclic amp accumulation in the presence of tsh. such an effect is also observed in horse, beef and sheep thyroid slices, but not in dog kidney slices stimulated by parathyroid hormone or in rat parotid slices stimulated by isoproterenol. the effect in dog thyroid slices is suppressed by 1mm naclo4, 1mm methimazole and 1mm propylthiouracil. similar data have been obtained for p ... | 1975 | 163738 |
| characterization of an in vitro persistent-state measles virus infection: species characterization and interference in the bgm/mv cell line. | serological methods of mixed agglutination and indirect immunofluorescence showed the bgm/mv cell line to possess monkey antigens. as a means of further characterizing the species constitution of the bgm/mv cell line, the species specificity of viral-induced interferon from these cells, as well as the response of these cells to exogenous interferons, was determined. low titers of spontaneously elaborated interferon capable of protecting monkey but not mouse cells were detected in bgm/mv culture ... | 1975 | 163789 |
| complement biosynthesis in vitro by rat hepatoma cell strains. | four separate rat hepatoma strains were examined for their capacity to synthesize complement (c). none of the strains synthesized detectable amounts of the first components (c-1), and only one strain (7800c-1) produced the fourth component (c4). however, each of the strains synthesized significant amounts of biologically active c-2 and c-3. three of the four strains also produced c-5 and the natural inhibitor of c-1 (c1 inh). two control rat cell strains (fibroblast and pituitary) did not synthe ... | 1975 | 163857 |
| mechanism of the suppressive effect of interferon on antibody synthesis in vivo. | mouse interferon preparations significantly suppress the in vivo antibody response to sheep red blood cells (srbc), a thymus-dependent antigen, and to salmonella typhimurium lipopolysaccharide (lps), a thymus-independent antigen. it is also possible to effect the late responses of antigen sensitive "memory" cells observed during secondary immunization by administration of interferon prior to primary immunization. the immunosuppressive activity of interferon was time- and dose-dependent. maximum ... | 1975 | 163863 |
| susceptibility of anaerobic bacteria to metronidazole: relative resistance of non-spore-forming gram-positive baccilli. | susceptibility of 358 clinical isolates of obligate anaerobes to metronidazole was determined by an agar-dilution technique. only 66% of all isolates were inhibited by 6.25 mug/ml, whereas 30% required larger than or equal to 50 mug/ml. considerable variation in susceptibility was observed among different genera and species of bacteria. fusobacterium was most senstitive, followed by clostridium, bacteroides and peptococcus, peptostreptococcus, veillonella and acidaminococcus, and non-spore-formi ... | 1975 | 163867 |
| the influence of intracellular levels of cyclic nucleotides on cell proliferation and the induction of antibody synthesis. | the intracellular ratio of adenosine 3',5'-cyclic monophosphate (cyclic amp) to guanosine 3',5'-cyclic monophosphate (cyclic gmp) may control the developmental pathway followed by antibody-forming cell (afc) precursors. the evidence for this is derived from several different types of experiments. first lipopolysaccharide (lps) which is mitogenic for b lymphocytes, stimulates rapid, transient changes in intracellular levels of cyclic gmp but not cyclic amp when added to mouse spleen cultures. cyc ... | 1975 | 163886 |
| growth cycle of arboviruses in vertebrate and arthropod cells. | | 1975 | 164052 |
| zwoegerziekte virus, the causative agent for progressive interstitial pneumonia (maedi) and meningo-leucoencephalitis (visna) in sheep. | the final results of experimental infections with virus recovered from the lungs of sheep suffering from progressive interstitial pneumonia (=zwoegerziekte=maedi) are reported. the virus could be reisolated from blood samples of all experimentally infected sheep. every animal produced antibodies against the virus. the neutralising, complement-fixing and precipitating antibodies remained present in the blood for six years. fourteen out of 21 intrapulmonarily infected sheep developed clinical and/ ... | 1975 | 164056 |
| the relation between the rabbit potency test and the response of sheep to sheep clostridial vaccines. | six commercially available clostridial vaccines comprising one oil-emulsion, two alum-precipitated and three aluminum hydroxide adjuvanted preparations, each containing between two and seven antigenic components, were administered to groups of 10 rabbits and eight sheep in accordance with manufacturers' recommendations. serum antitoxic values to cl welchii beta, cl welchii epsilon, cl septicum, cl oedematins and cl tetani toxins were determined 14 days after completion of each vaccination course ... | 1975 | 164058 |
| serologic response of lambs to live virus vaccines containing infectious bovine rhinotracheitis, bovine virus diarrhea and bovine myxovirus parainfluenza-3. | | 1975 | 164079 |
| an outbreak of c welchii type c enterotoxaemia in young lambs in south west scotland. | | 1975 | 164082 |
| progesterone-binding proteins: in vitro binding and biological activity of different steroidal ligands. | progesterone-binding proteins from human, rabbit, sheep and guinea pig myometrial cytosol, all induced with oestradiol, as well as from pregnant guinea pig myometrium and plasma were investigated. the physico-chemical properties of the oestradiol-induced binding proteins were very similar in all the species studied. in all, 63 steroids were tested for their ability to compete with tritiated progesterone for the binding sites on these six proteins and their relative affinities were determined. th ... | 1975 | 164094 |
| progesterone-binding proteins from endometrium and myometrium of sheep uterus: a comparative study. | the binding of tritiated proesterone to the cytoplasmic progestogen receptors from oestrogen-primed sheep endometrium and myometrium has been investigated. the binding characteristics of the progesterone receptors from both sources were determined in the supernatant fractions obtained after high speed centrifugation of the myometrial and endometrial homogenates. high affinity binding proteins with identical association constants for progesterone (1 times 10-9 m-1) were detected in both endometri ... | 1975 | 164095 |
| crimean hemorrhagic fever-congo (chf-c) virus antibodies in man, and in domestic and small mammals, in iran. | a crimean hemorrhagic fever-congo (chf-c) virus antibody survey was carried out in iran with sera from man and several animal species; this survey was done by means of agar gel diffusion precipitation (agdp) test with the following results (percent positive of number tested): men, 13% of 351; sheep, 38% of 728; goats, 36% of 135; cattle, 18% of 130; camels, 0% of 157; small mammals, 3% of 274. a number of sera were tested by complement-fixation (cf), neutralization (n), and hemagglutination-inhi ... | 1975 | 164135 |
| effects of thyroid and ovaries on prolactin binding activity in rat liver. | 125i-radiolabeled ovine prolactin (oprl) binding activity was measured in microsomal membranes of liver tissue from intact, ovariectomized, ovariectomized-thyroidectomized, and ovariectomized-thyroidectomized rats injected with thyroxine (t4) or estradiol benzoate (eb). thyroidectomy and ovariectomy each reduced prl binding activity in liver tissue significantly. the combination of ovariectomy and thyroidectomy decreased prl binding activity more than thyroidectomy or ovariectomy alone. doses of ... | 1975 | 164346 |
| determination of toxin-induced leakage of different-size nucleotides through the plasma membrane of human diploid fibroblasts. | human diploid lung fibroblasts were treated with cytolytic bacterial toxins and the nature of the membrane damage was investigated. [3h] uridine was used for differential labeling of cytoplasmic components of small or large molecular size. two principal size categories were achieved by labeling the fibroblasts in either early growth phase or stationary phase, a high-molecular weight ribonucleic acid label and a low-molecular-weight nucleotide label. the size of the labeled molecules was determin ... | 1975 | 164404 |
| specific susceptibility of sensitized (memory) b cells to suppression and antigenic alteration by murine leukemia virus. | mice infected with murine oncogenic rna viruses, either friend virus (fv) or moloney leukemia virus (mulv-m) reacted well to a primary immunization with antigen(s) of vibrio cholerae; both the kinetics and magnitude of the direct (igm) primary vibriolytic antibody plaque forming cell (pfc) response in the spleen was the same as in non-infected control mice. in contrast, the anamnestic pfc (igm) response of mice preimmunized with cholera and later (2 to 9 months following priming) infected with e ... | 1975 | 164504 |
| distinction between malignant l cells and normal mouse fibroblasts by rosette formation with sheep red blood cells. | murine l cell fibroblasts, and derivatives were found to rosette with sheep red blood cells (srbc). primary fibroblast explants from the parent murine strain, c3h, did not possess this potential. no rosettes were observed with primary fibroblast explants from c57bl and b10br mice, with a human fetal lung fibroblast, with baby hamster fibroblasts or their polyoma transormed derivative, or with a cell line, 1t-22, derived from balb/c mice. hybridization of 1t-22 and l cells, by sendai virus-mediat ... | 1975 | 164508 |
| adrenocorticotropin. 47. synthesis and biological activity of adrenocorticotropic peptides modified at the tryptophan position. | three biologically active peptides, [9-beta-(1-naphthyl)alanine]-acth-(1-19), [9-ni-formyltryptophanl-acth-1(1-19), and (8-lysine,9-phenylalaninel-acth-1(1-9), have been synthesized by the solid-phase method. all of the synthetic peptides showed diminished biological activity compared to acth-(1-19). it was also shown that the steroidogenic and lipolytic activities of acth-(1-19) were not inhibited by [8-lysine,.-phenylalanine]-acth-(1-19). | 1975 | 164551 |
| improvements in the modified direct complement fixation test and its application in the detection of bluetongue antibodies in cattle and sheep sera. | in this study, improvements were made in the technique and the preparation of the antigen. it was possible to perform three extractions and elutions resulting in a soluble reactive preparation from each batch of infected mouse brain. this led to an appreciable increase in the yield of highly reactive antigen. the presence of bluetongue antibodies was not detected in 13,210 sheep sera. of the 13,486 bovine sera tested, only three questionable reactions were obtained. it was possible to determine ... | 1975 | 164994 |
| restorative effect of normal human serum, transfer factor and thymosin on the ability of heated human lymphocytes to form rosettes with sheep erythrocytes. | | 1975 | 165007 |
| adenoviruses of man and animals. | adenoviruses are capable of causing natural infections in a wide variety of vertebrates, including amphibia, birds and mammals. although frequently causing inapparent infections, they may be associated with diseases of varying severity and localizations. the clinico-pathological manifestations most commonly associated with adenovirus infections involve the respiratory tract and the ocular conjunctiva. involvement of the digestive, renal and nervous systems may also be observed. a state of latenc ... | 1975 | 165118 |
| live and killed virus vaccines: their use against the respiratory diseases of cattle. | the respiratory diseases of cattle are due to a combination of different factors among which figures a viral infection. the antiviral vaccination, perfectly possible owing to associated killed vaccines and live virus, is thus a very important element which must enter into every general plan of prophylaxis. moreover, these plans will concern bacterial infections, conditions of rearing, etc. we have demonstrated that it is possible to produce good immunity in calves and sheep using a trivalent kil ... | 1975 | 165130 |
| the importance of picornavirus infections in respiratory disease of man and other mammals. | picornaviruses may be divided, by physicochemical properties, into enteroviruses, cardioviruses, caliciviruses, rhinoviruses and foot-and-mouth diseases viruses. although the respiratory tract may be the primary site of entry and multiplication for enteroviruses, cardioviruses and fmd viruses, few agents in these groups cause respiratory disease. a notable exception is coxsackievirus a21 which is an important cause of upper respiratory tract diseases in military recruits. the picornaviruses whic ... | 1975 | 165133 |
| pilot experiments with eb virus in owl monkeys (aotus trivirgatus). iii. serological and biochemical findings in an animal with reticuloproliferative disease. | nucleic acid hybridization with eb virus complementary rna has demonstrated unequivocally that eb virus dna is present in the cells of a continuous lymphoblastoid line established in culture from a pathological lymph node of an owl monkey with reticuloproliferative disease after inoculation with eb virus. there were 48 to 49 eb virus genome equivalents per cell. in addition, serological studies showed that the diseased owl monkey developed specific antibodies to eb virus capsid antigens. the ant ... | 1975 | 165147 |
| the mucosubstance coating the pneumonocytes in the lungs of xenopus laevis and lacerta viridis. | the layer of mucosubstance that is associated with the free surface membranes of the pneumonocytes in the lungs of the toad xenopus laevis and the lizard lacerta viridis was demonstrated by electron microscopy using iron oxide stain. the form and staining reactions of the mucosubstance layer were similar in both animals. in electron micrographs the mucosubstance was represented by a band of densely stained material (25-50 nm thick) which coated the entire free surface of the pneumonocytes. it ap ... | 1975 | 165163 |
| study of pseudomonas haemolysin. ii. characteristics of pseudomonas haemolysin. | haemolysins of 4 strains of pseudomonas aeruginosa producing different fractions [ii, 2 + ii, i + ii + iii] were studied. the production of specific antibodies was demonstrated making possible the immunoelectrophoretic record of the whole lysin and of the individual fractions. tests on laboratory animals [mice, rabbits] showed a high degree lethal and dermonecrotic property of the lysin containing the fractions ii + iii and i + ii + iii. | 1975 | 165235 |
| stimulation and inhibition with lh and other hormones of female mammalian meiosis in vitro. | utilizing some known physiological preovulatory hormone levels and specific cytological end-points, experiments were carried out with two different media to obtain a clearer understanding of meiotic maturation in vitro of ewe, cow, monkey and human oocytes. in the first series of experiments, it was shown that, in mccoy's medium, ovine lh, prostaglandin e1 and ovine prolactin increased the percentage of divisions of ewe oocytes, without camp as a demonstrable intermediate. monkey oocytes incubat ... | 1975 | 165291 |
| distribution of delta-5 -3beta-hydroxysteroid dehydrogenase activity in the graafian follicle of the sheep. | the localization of delta-5 -3beta-hydroxysteroid dehydrogenase (3 beta-hsd) has been examined in ovarian follicles in vivo and in vitro, and related to oestrogen and progesterone production. in vivo, during the oestrous cycle, enzyme activity was restricted to the theca interna of the one or two most advanced follicles in each animal, but was present only between day 2 and 5 and between day 13 and ovulation. high levels of oestrogen were found in the ovarian venous blood only when follicles con ... | 1975 | 165292 |
| inhibition of bovine leukemia virus release. | sera from 3 cows with the adult form of lymphosarcoma inhibited release of leukemia virus from a cell line of fetal lamb spleen infected with bovine leukemia virus (blv). sera from 5 to 7 cattle experimentally infected with blv also suppressed virus release. the inhibition of virus release was reversible. sera from cattle with the calf form and the thymic form of lymphosarcoma and normal bovine control sera did not repress virus release. | 1975 | 165311 |
| methods for assessing thyroid stimulating hormone effects on thyroidal iodide transport. | | 1975 | 165375 |