| studies on human thyroxine-binding globulin (tbg). ix. some physical, chemical, and biological properties of radioiodinated tbg and partially desialylated tbg. | thyroxine-binding globulin (tbg) and partially desialylated or slow tbg (stbg) were purified from human serum by affinity chromatography. purified tbg was identical to tbg present in serum by the criteria of electrophoretic mobility, affinity for thyroxine (t4), and heat-inactivation response. purified stbg had slower electrophoretic mobility and lower affinity for t4. both bound t4 in an equimolar ratio, were immunoprecipitable, and had similar inactivation t1/2 at 61 degrees c. tbg and stbg we ... | 1975 | 806610 |
| radiation dose distributions and their optimization. | the current situation in the radiotherapy treatment of carcinoma of the larynx is discussed from a physicist's point of view and in the light of the results of one series of patients. the results suggest that the spatial distribution of dose obtainable with supervoltage irradiation for treatment of t1, to t4 no mo cases is not far from the ideal, and that it is not difficult to prescribe an optimal distribution. a significant difference in the rate of local cure was found between those treated ... | 1975 | 806760 |
| effect of thyrotropin-releasing hormone (trh) on plasma glucocorticoids and thyroxine in cattle. | the repeated systemic infusion of trh (200 mug, twice daily) was effective in repeatedly elevating plasma t4 levels (20-40 min postinfusion) for the 3 experimental days. the post-trh treatment (saline infusion) exhibited a depression of plasma thyroxine levels, possibly explained by previous high thyroxine levels exerting a suppressive effect on the hypothalamic-pituitary-thyroid axis. a depression of plasma glucocorticoid levels was shown within 1 hr in both experiments after trh administration ... | 1975 | 806923 |
| construction and characterization of a chimeric plasmid composed of dna pfrom escherichia coli and drosophila melanogaster. | a chimeric plasmid has been constructed in vitro from colicin e1 factor (col e1), nontransmissible r-factor rsf-1010, and drosophila melanogaster dnas by the sequential action of escherichia coli endonuclease ri(eco ri) and t4 phage dna ligase. the chimeric plasmid was assembled in two stages--first, a composite plasmid consisting of col e1 and rsf 1010 was constructed, followed by partial digestion of the composite with eco ri (in order to open one of the susceptible cleavage sites) and ligatio ... | 1975 | 807234 |
| discrepancy between the measurement of thyroxine-binding prealbumin plasma level and binding capacity in protein-calorie malnutrition. | the measurement of thyroxine-bindung prealbumin (tbpa) in protein-calorie malnutrition by two different techniques leads to the recognition of an unexpected discrepancy. whereas tbpa plasma levels as measured by immunodiffusion are markedly decreased to 29.3% of the normal, those recorded by maximal binding capacity (tbpacap) are characterized by a wide dispersion. in the control group, the ratio between tbpacap and tbpa plasma level is 9.1. in the malnourished group on admission, the same ratio ... | 1975 | 807481 |
| [clinical studies on regulatory system of thyroid hormone secretion and serum triiodothyronine. part. i. solid-state radioimmunoassy for human serum tsh and its clinical application (author's transl)]. | a solid-state ria method using a plastic microtiter plate for human tsh was developed: 1) the choice of carrier protein for standard tsh was critical in this method and pooled sera from untreated graves patients was found to be suitable for this purpose. the mean lowest detectable tsh level was 0.2 muu/assay, which was almost equal to those reported by other methods. this method is superior in simple assay procedure, especially in the separation of bound and free tsh and in the shorter incubatio ... | 1975 | 807487 |
| [clinical studies on regulatory system of thyroid hormone secretion and serum triiodothyronine. part ii. development of rapid radioimmunoassay for triiodothyronine (author's transl)]. | a rapid and simple radioimmunoassay method for serum t3 was developed using home made potent rabbit anti-t3 serum: 1) the incubation mixture which contained 0.1 ml of 1:2,000 diluted anti-t3 serum (finally 1:20,000), 250 mug of 8-anilino-1-naphthalene sulphonic acid and 0.1 ml of serum was run at 37 degrees c for 1 hour. dextran-coated charcoal was added for separation of free and bound t3. no significant undersirable effects due to high incubation temperature and short incubation time was obser ... | 1975 | 807488 |
| subunit arrangement in the extended sheath of pyocin r. | an optical diffraction study has been made of electron micrographs of extended sheaths of pyocin r. it has been demonstrated that the extended sheath consists of annuli of six subunits, which are arranged in a helix of 3.57 annuli per one turn. the annulus repeat in the helix direction is 35a. the dimensions and probably the helical parameters of pyocin r sheath are different from those of t4 phage tail, but a structural correlation appears to exist between the extended sheath of pyocin r and th ... | 1975 | 807567 |
| high incidence of decreased serum triiodothyronine concentration in patients with nonthyroidal disease. | serum thyroxine (t4) and triiodothyronine (t3) concentration and binding were measured in 34 clinically euthyroid patients hospitalized for a wide variety of nonthyroidal diseases. despite clinical euthyroidism, serum t3 was in the hypothyroid range (less than 90 ng/100 ml) in 24 of the 34 patients, and the mean serum t3 of this group, 78.4 +/- 38.3 (sd), was significantly decreased from that of control, 134.0 +/- 29.3 ng/200 ml. mean serum t4 levels were essentially the same in both groups, 7.3 ... | 1975 | 807593 |
| patterns off recovery of the hypothalamic-pituitary-thyroid axis in patients taken of chronic thyroid therapy. | to determine the patterns of recovery of the hypothalamic-pituitary-thyroid axis following long-term thyroid hormone therapy, trh tests were performed on 8 euthyroid nongoitrous patients, 5 euthyroid goitrous patients, and 5 hypothyroid patients while they were taking full doses of thyroid hormone and 3, 7, 10, 14, 17, 21, 28, 35, 42, 49, and 56 days after stopping it. serum tsh, t3, and t4 were measured before and at multiple intervals over a 4-h period after giving 500 mug trh iv. in euthyroid ... | 1975 | 807596 |
| the thyroxine-binding properties of serum proteins. a competitive binding technique employing sephadex g-25. | a competitive binding technique is described for the estimation of the thyroxine (t4)-binding properties of serum proteins in dilute blood serum and lymph. when used in conjunction with an assay for total t4 the following parameters can be estimated: the number of functionally different t4 binding proteins, their individual association constants and binding capacities for t4, the amount of t4 which is bound to each binding species, and the concentration of unbound (free) t4. both human and sheep ... | 1975 | 807668 |
| subacute thyroiditis in a lateral thyroid gland: evaluation of the pituitary-thyroid axis during the acute destructive and the recovery phases. | subacute thyroiditis in a lateral, ectopic thyroid has been previously unreported. a 4 10/12-year-old girl had an enlarging mass in the left upper anterior neck. initially, the serum concentration of t4 was normal, t3 was elevated, and tsh was undetectable without response to trh. rai uptake was 1%. the data were consistent with subacute thyroiditis. twelve weeks later the serum concentration of t4 was low and tsh was elevated; thyroid replacement therapy was given for 20 weeks. when this was di ... | 1975 | 807695 |
| the one-step approach to thyroid function tests. the diagnostic thyroxine ratio (dtr)/serum thyroxine (t4) level combination. | a one-step approach to thyroid function tests is reported, using tetralute kits (ames). two parameters are obtained simultaneously--namely, the serum thyroxine (t4) level and the diagnostic thyroxine ratio (dtr), which correlates well with the free thyroxine index (fti) as determined by two separate tests-the t4 level and the triiodothyronine resin uptake ((t3u)) estimations. data presented from patients with a variety of thyroid states prove that the dtr, particularly in combination with the t4 ... | 1975 | 807790 |
| radioimmunoassay and the hormones of thyroid function. | radioimmunoassay (ria) has provided the tools for wide-reaching investigations that have changed and continue to change many important concepts of thyroid physiology and pathosphysiology. the ria vor human thyrotropin (tsh) was developed in 1965; development of the ria for triiodothyronine (t3), thyroxine (t4), thyroxine-binding globulin (tbg), and, recently, thyrothropin-releasing hormone (trh) and thyroglobulin (tg) followed. the capacity to measure nanogram and picogram concentrations with re ... | 1975 | 807972 |
| different effects of oral doses of triiodothyronine or thyroxine on the inhibition of thyrotrophin releasing hormone (trh) mediated thyrotrophin (tsh) response in man. | since contradicting results about the existence of t3 or t3 and t4 receptors in pituitary tissue have been reported, the influence of l-triiodothyronine (l-t3) or l-thyroxine (l-t4) on trh stimulated tsh release was investigated. oral administration of 50 mug l-t3 caused an increasing inhibition of tsh response to 400 mug trh from 64% 2 h after l-t3 intake to 29% after 24 h, while serum t3 peaks up to 5.45 ng/ml occurred between 2 to 4 h after l-t3 ingestion and became normal after 8 to 10 h. th ... | 1975 | 808065 |
| the effect of hypoglycemia on hypothalamic thyrotropin-releasing hormone (hrh) in the rat. | a rapid radioimmunoassay for trh with a high degree of specificity and sensitivity is described. the procedure is capable of measuring trh in amounts less than 15 pg/tube. such an assay system has enabled us to study the effect of hypoglycemia on hypothalamic trh content. forty-eight female, adult holtzman rats were divided into 8 groups of 6. regular insulin was injected intraperitoneally into each rat except for the basal group. a separate batch of similar rats was studied in the same fashion ... | 1975 | 808409 |
| [clinical studeis on the regulatory system of thyroid hormone secretion and serum triiodothyronine. part iii. studies on thyroid hormone change and its relationship when tsh in cases with subclinical hypothyroidism (hashimoto's thyroiditis and 131i treated graves' disease)]. | changes in thyroid hormone levels and their relationship with tsh in cases with hashimoto's thyroiditis and 131i treated graves' disease in subclinical hypothyroid state were investigated: 1) in 34 cases with hashimoto's thyroiditis, tsh levels was 14.7 +/- 26.8 muu/ml (mean +/- s.d.), t3 144.5 +/- 33.6 rg/100 ml; t4 6.7 +/- 2.4 mug/100 ml; t3ru 25.4 +/- 3.2%; f.t.i. 2.0g +/- o.89; t3/t4 2.46+/- 1.04%. it was noted that tsh levels revealed significant positive correlation with t3/t4 (r=0.77); si ... | 1975 | 808432 |
| [studies on hypophyseo-thyroid function in patients with chronic thyroiditis (author's transl)]. | it is well known that serum tsh levels are elevated in most patients with chronic thyroiditis, even if the patient exhibits normal thyroid function tests. the determination of serum tsh levels in these patients is thought to be the most sensitive indicator of subclinical hypothyroidism. in this study, the hypophyseo-thyroid functions of untreated euthyroid patients with chronic thyroiditis were evaluated. serum t3 levels in most of these patients were raised or at high normal levels, although se ... | 1975 | 808434 |
| serum thyroxine and thyroxine-binding proteins in chronic renal failure without nephrosis. | total serum thyroxine (t4), free thyroxine index (fti), thyroxine binding globulin (tbg) binding capacity, serum albumin, alpha-globulins and urinary protein excretion were measured in 50 patients with chronic renal failure, but without nephrotic syndrome. 25 patients were undergoing chronic hemodialysis. t4 was within the normal range in most patients. there was a tendency to lower t4 values as compared to an age and sex-matched control group, but this did not reach statistical significance. tb ... | 1975 | 808556 |
| failure of propranolol to alter thyroid iodine release, thyroxine turnover, or the tsh and prl responses to thyrotropin-releasing hormone in patients with thyrotoxicosis. | a dual isotope method allowing simultaneous analysis of both endogenous thyroidal release and peripheral thyroxine disposal was employed in four patients with thyrotoxicosis before and during propranolol therapy (160 mg/day) to determine whether beta adrenergic blockade with this agent affected the secretion or metabolism of thyroid hormone. since catecholamines may be involved in the regulation of both thyrotropin (tsh) and prolactin (prl) release from the pituitary, the effect of propranolol o ... | 1975 | 808558 |
| clinical evaluation of new indicators of free thyroxine concentration and thyroxine-binding globulin capacity. | a rapid and simple method is described for the indirect measurement of free thyroxine (t4) concentration and maximal thyroxine-binding globulin (tbg) capacity applying a single kit of thyopac-4. initially, a value for total t4 is determined, after which the patient's serum is added to permit estimation of t4 corrected for abnormal tbg concentration. the ratio of increased radioactivity in the supernatant after the addition of patient's serum to that obtained using pooled normal serum is designat ... | 1975 | 809219 |
| the late effects of neonatal hyperthyroidism upon the feedback regulation of tsh secretion in rats. | rats made thyrotoxic with large doses of thyroxine (t4) during the neonatal period (neo-t4) show many abnormalities as adults. these usually include impaired body, pituitary and thyroid growth, diminished pituitary and serum tsh concentrations, a diminished serum t4 and a diminished response to ptu challenge and to thyrotropin-releasing hormone (trh) stimulation. experiments are presented which show that these rats are hypersensitive to feedback regulation by t4 in a manner similar to that seen ... | 1975 | 809256 |
| estimation of the maximal t4-binding capacity of tbg using the triosorb test in serum treated with dextran-coated charcoal. | a new method for the estimation of the maximal t4-binding capacity of tbg (max. tbg) in serum (dextran-coated charcoal-triosorb method) was devised. thyroxine (t4) concentration in test sera were determined by the tetrasorb method and then t3 resin sponge uptake (t3 rsu) was determined after extraction of 70% of the endogenous t4 with dextran-coated charcoal. the binding capacity of unsaturated tbg in treated sera was estimated from the reciprocal of t3 rsu. max. tbg was calculated from the ari ... | 1975 | 809258 |
| ribonucleoside diphosphate reductase induced by bacteriophage t4. iii. isolation and characterization of proteins b1 and b2. | ribonucleoside diphosphate reductase determined by bacteriophage t4 consists of a tight complex (alpha2beta2) of the polypeptide chains alpha (mr = 80,000 to 85,000) and beta (mr = 35,000). the alpha2 dimer (= protein b1) was purified from escherichia coli b infected with t4 mutant nrdb55 (yeh, y.c., and tessman, i. (1972) virology 47, 767-772) which carries an amber mutation in the gene coding for the beta polypeptide chain. protein b1 contained binding sites for datp, an allosteric effector of ... | 1975 | 809436 |
| detection of human anti-thyroxine and anti-triiodothyronine antibodies in different thyroid conditions. | anti-thyroxine (t4) and anti-triiodothyronine (t3) antibodies have been demonstrated in man. it was assumed that antibodies were at least partially saturated in vivo by the hormones. the initial step of the method therefore consisted in a dissociation of the postulated antigen-antibody complex by a 45% ammonium sulfate precipitation. the second part of the method consisted in incubating the euglobulins with trace amounts of 125i-t3 and 131i-t4. the hormones bound to the gammaglobulins were then ... | 1975 | 809458 |
| thyroxine in human amniotic fluid. | total and free t3 and t4 concentrations were measured in human amniotic fluid and in fetal and maternal blood. before 20 weeks, the mean af-t4 level was 0.24 mug/dl; there is a progressive increase in concentration with gestational age. at term, the mean af total t4 level was much less (0.64 mug/dl) than in fetal or maternal serum (9.3 and 11.3 mug/dl, respectively). most of the t4 (99.4%) in af is protein bound, presumably to tbg as in serum, but the mean ft4 concentration in af at term (4.13 n ... | 1975 | 809559 |
| [therapy and prevention using t3/t4 hormone. 5 years of clinical and practical experience with novothyral]. | | 1975 | 809635 |
| effects of acute and chronic administration of trh on tsh and prolactin secretion in normal and hypothyroid rats. | intravenous injection of the synthetic tripeptide (pyroglu-his-pro-nh2:trh) effected the prompt release of tsh and prolactin (prl) from the pituitary of the goitrous rat. plasma tsh and prl levels increased 2-3-fold within 1 min after the injection of 0.4 and 2 mug trh. intravenous injection of 20 mug of l-thyroxine (t4) induced repletion of tsh to supranormal levels in the adenohypophysis of goitrous rats without a significant change in prl stores. the acute administration of trh (2 and 50 mug) ... | 1975 | 809721 |
| [peripheral conversion of t4 and t3 in man]. | our investigations of the peripheral metabolism of t4 and t3 in man demonstrate clearly that t3 is secreted by the thyroid gland and is peripherally formed by conversion from t4. the calculation of the disposal rates indicate furthermore that 40% of the daily metabolised t4 is converted to t3. in this way more than 60% of the daily production of t3 results from peripheral conversion of t4. our results support the hypothesis that the physiological action of the thyroid hormones is effected mainly ... | 1975 | 809755 |
| [principals of hormone substitution in thyrectomized patients with carcinoma of the thyroid gland (author's transl)]. | the substitution of thyrectomized patients with carcinoma of the thyroid with l-thyroxin has advantages compared to a substitution with triiodothyronine, 200 mug t4/d are sufficient to obtain a negative trh test in most patients. for security it is suggested to performe a general substitution of these patients with 300 mug t4/d. this dose is very well tolerated. to high doses of substitution cause a "damage" of the thyreotrop in a part of the patients. this is demonstrated by a transient thyreot ... | 1975 | 809804 |
| prognostic value of thyrotropin-releasing hormone stimulation test in endogenous depression. | thyrotropin-releasing hormone (trh) stimulation tests were performed in 19 patients with endogenous depression before treatment and when they had apparently recovered following antidepressive treatment. an increase in the maximal serum thyrotropin (tsh) response to trh of more than 2.0 muu/ml was found in all of ten patients who did not relapse, while such an increase was found in only one of nine patients who did relapse within 6 months. i. e., a correct prognosis was possible in 94.7% (95% con ... | 1975 | 809999 |
| protirelin stimulation test and thyroid function during treatment of depression. | thyroid levels were estimated in 15 patients with endogenous depressions. before electroconvulsive treatment (ect), serum thyroxine (t4) and free t4 index values were elevated (p less than .02). after recovery from depression, the levels were normal. serum triiodothyronine (t3) and free t3 index were normal both before and after ect. serum thyrotropin (tsh) levels were also normal and not substantially altered by the ect procedure. the mean maximal tsh response to protirelin (thyrotropin-releasi ... | 1975 | 810113 |
| comparison of serum free thyroxine indices and "corrected" thyroxine tests. | a dual competitive protein-binding assay for serum thyroxine (t4) is described. the assay is called the "corrected" t4 index and can be performed simultaneously with the determination of total t4. this method correlated significantly with the free t4 index and the effective t4 ratio. the "corrected" t4 index was compared for precision and diagnostic accuracy with the effective t4 ratio and two different free t4 indices. improved modifications of the thyroxine and triiodothyronine sephadex uptake ... | 1975 | 810277 |
| effect of hypothalamic deafferentation on the secretion of thyrotropin in resting conditions in the rat. | complete hypothalamic deafferentation in normal male rats, either limited to the median eminence, arcuate nucleus, and basal parts of ventromedial nuclei, or including, in addition, the ventromedial nuclei, dorsomedial hypothalamus, and a large part of the posterior hypothalamus, caused a decrease of resting serum tsh levels and a marked lowering of the pituitary tsh concentration. partial frontal anterior cuts caused similar changes, whereas partial posterolateral cuts, or a complete deafferent ... | 1975 | 810344 |
| development of the hypothalamic-pituitary-thyroid axis in the neonatal rat. | the hypothalmic content of thyrotropin-releasing hormone (trh), the pituitary concentration of thyroid-stimulating hormone (tsh), and the serum concentrations of tsh, thyroxine (t4), and triiodothyronine (t3) have been determined at different intervals during the first 50 days following birth in the rat. from a minimum concentration of 1 pg/mug protein at birth, the hypothalamic concentration of trh increased to a maximum of 5 to 6 pg between 16 and 28 days of age. serum and pituitary tsh concen ... | 1975 | 810345 |
| thyrotropin releasing hormone (trh): dopa potentiation and biogenic amine studies. | the present study in mice demonstrated the trh when administered over 5 days remained active in the everett dopamine potentiation test. no evidence of tolerance was observed. in fact, an accumulative effect of trh appeared to take place. ablation of the adrenals, ovaries, testes, pineal, spleen, parathyroid, one kidney, or thymus did disrupt this behavioral potentiation of dopamine by trh. trh was found to potentiate the effects of imipramine. t3, t4, and tsh were found to be active in the dopa ... | 1975 | 810812 |
| thyroid hormones in the elderly sick: "t4 euthyroidism". | thyroid function and serum levels of triiodothyronine (t3) and thyroxine (t4) were investigated in 79 euthyroid geriatric patients. of the 59 inpatients and 20 outpatients 35 (59%) and 2, respectively, had low t3 levels. in contrast, 7 (12%) and 6 (30%), respectively, had raised t4 levels. two further patients were excluded from the study because of raised levels of thyroid-stimulating hormone. thyroxine-binding globulin was greatly increased in both groups of patients, but low serum albumin lev ... | 1975 | 811313 |
| gonococcal growth factors in tissue cultures. | growth of neisseria gonorrhoeae in the presence of rhesus monkey kidney (re2) cells containing eagle's minimal essential medium (mem) 'conditioned' by 18-20 h of contact with re2 cells began 3-4 h after inoculation and by 16-20 h had reached a maximum. when 'conditioned' medium (cm) was removed from the tissue cells and replaced with fresh medium a 5-6 h lag period occurred before multiplication of gonococci began and by 16 h growth was also near a maximum. cm removed from tissue cells supported ... | 1975 | 811344 |
| heterologous deoxyribonucleic acid uptake and complexing with cellular constituents in competent bacillus subtilis. | with competent cultures of bacillus subtilis the uptake of escherichia coli deoxyribonucleic acid (dna) is about 50% that for homologous dna. uptake of phage t6 dna, if any, is of the order of 7%, while nonglucosylated phage t6 (t6) dna is taken up almost as effectively as homologous dna. both t6 and t4 dna interfere only minimally with uptake of homologous dna; by contrast, t6 dna competes with homologous dna as effectively as the latter itself. these results indicate that the glucose residues ... | 1975 | 811646 |
| pathogenesis and immunology of experimental gonococcal infection: role of iron in virulence. | addition of iron componds to inocula of the relatively avirulent t3 or t4 colony types of gonococci increased their lethality for chicken embryos after intravenous inoculation but had little or no effect on the highly virulent t1 or t2 types. the toxicity of nonviable inocula, killed cells or sonicates, was not significantly affected by ecogenous iron. addition of the iron-binding protein conalbumin reduced or delayed the lethal effect of t1, but not t3, gonococci although growth of both colony ... | 1975 | 812826 |
| repression of sporulation in bacillus subtilis by l-malate. | l-malate repressed sporulation in the wild-type strain of bacillus subtilis. when 75 mm l-malate was added to the growth medium at the time of inoculation, the appearance of heat-resistant spores was delayed 6 to 8 h. the synthesis of extracellular serine protease, alkaline phosphatase, glucose dehydrogenase, and dipicolinic acid was similarly delayed. sporulation was not repressed when malate was added to the culture at t4 or later. a mutant was selected for ability to sporulate in the presence ... | 1976 | 812866 |
| reciprocal changes in serum concentrations of 3,3',5-triiodothyronine (t3) in systemic illnesses. | serum concentrations of 3,3',5'-triiodothyronine (reverse t3, rt3) were measured in adult patients with several systemic illnesses whose serum total and/or free t3 were low, serum total t4 was low or normal, and free t4 was either normal or elevated. the mean serum rt3 was 76, 46, and 77 ng per 100 ml in patients with hepatic cirrhosis, chronic renal failure, and acute febrile illnesses, respectively; the values in patients with hepatic cirrhosis and acute febrile illness were significantly high ... | 1975 | 812882 |
| klinefelter's syndrome: examination of thyroid function, and the tsh and prl responses to thyrotropin-releasing hormone prior to and after testosterone administration. | thyroid function and prolactin (prl) responsiveness to thyrotropin-releasing hormone (trh) were examined in 6 patients with klinefelter's syndrome prior to and after therapy with testosterone. the thyroid function tests, including serum triiodothyronine (t3), thyroxine (t4), thyroxine binding globulin (tbg), resin t3 uptake (rt3u), radioactive iodine uptake (raiu), thyrotropin (tsh) stimulation and the tsh response to trh were normal during both periods of study. testosterone treatment had no si ... | 1975 | 812883 |
| a lack of inhibitory action of bacteriophage t4 ghosts in the presence of edta. | adsorption of bacteriophage t4 ghosts on to escherichia coli cells has been known to cause a dramatic change in the cellular metabolism, the effect being similar to that of colicin k. it is shown here that the inhibitory activity of ghosts is not expressed either at 0 degrees c in the ordinary media (like colicin k) or even at 30 degrees c in a medium containing edta, in contrast to colicin k. since the process of sheath contraction of t4 phage is blocked by edta, it is suggested that the adsorb ... | 1976 | 812954 |
| evaluation of thyroid function during growth hormone therapy. | decrease in the blood levels of pbi, in the thyroidal uptake of iodine, and diminished effect of trh on tsh release have been reported to occur during growth hormone administration. we assessed thyroid function indices in two groups of growth hormone deficient children before and during long-term hgh therapy. eight patients were given tsh prior and at 2, 4, and 6 mo of growth hormone treatment. in four other children, the disposal rates of simultaneously administered i125-t4 and i131-t3 were mea ... | 1976 | 813086 |
| binding of l-triiodothyronine to isolated rat liver and kidney nuclei under various circumstances. | triiodothyronine (t3) is specifically bound by nuclei from rat liver and kidney. binding of t3 at 37 degrees c reaches its maximum at 30 min. in the presence of edta (to remove mg2+) t3 binds to a class of binding sites with an estimated equilibrium association constant (ka) of 3.3 x 10(10) m(-1) and a maximal binding capacity (mbc) of 3.8 fmol t3/100 mug dna. in the presence of mgcl2 t3 binds to a second class of binding sites with an estimated ka of 4.8 x 10(8) m(-1) and a mbc of 123 fmol/100 ... | 1976 | 813471 |
| [response of thyrotropin (tsh) to the stimulation with hypothalamic releasing factor (trf) in hypothyroid children]. | the normal human serum thyrotropin (tsh) measured by radioimmunoassay in 36 children was 3.3 +/- 1.13 muui/ml. no differences dependent on age or sex were found. stimulation by intravenous injection of 100 mug of trf has been carried out in 7 euthyroid children and in 14 with hypothyroidism. tsh was determined prior to, and during trf stimulation. among other thyroid tests included in this study were: serum t3 uptake, total thyroxine, serum protein-bound iodine, 131ina uptake and thyroid scannin ... | 1975 | 813748 |
| delayed adjustment of the pituitary response to variations in circulating thyroid hormones in a case of subacute thyroiditis. | in a case of subacute de quervain thyroiditis characterized by a period of pronounced hypermetabolism followed by hypometabolism, levels of t4, t3 and the tsh response to trh were repeatedly measured. as expected, the response to trh was absent or low during the hypermetabolic phase, high during the hypometabolic phase and returned to normal with recovery. however, at the beginning and at the end of the hypometabolic phase, while circulating levels of t3 and t4 both lay in the subnormal range, t ... | 1976 | 813919 |
| thyrotropin-releasing hormone and thyroid hormone interactions on thyrotropin secretion in the rat: lack of inhibiting effects of small doses of triiodo-l-thyronine in the hypothyroid rat. | rats were thyroidectomized (t) and injected once daily with thyroxine (t4) or triiodothyronine (t3) ip; circulating thyrotropin (tsh) levels and tsh response to 100 ng of thyrotropin releasing hormone (trh) iv, were measured in different groups of rats at several intervals after the last dose of t4 or t3. it was found that t rats on 1.8 mug t4 or 0.4 mug t3/100 g bw/day, response to trh decreased after the injection of the hormone, maximum suppressive effect being found about 7-8 h after t4, or ... | 1976 | 813987 |
| pituitary-thyroid axis in neonatal and adult rats: comparison of the sexes. | systematic comparisons have been made of the development of the pituitary-thyroid axes of male and female rats, by measuring plasma thyrotropin (tsh) and thyroxine (t4) concentrations in neonates and adults. observations were made in untreated groups as well as in rats treated with various regimens of exogenous t4, thyrotropin-releasing hormone, or tsh. all hormone determinations were by radioimmunoassay (ria). salient findings include the following: 1) in early neonatal life, untreated rats sho ... | 1976 | 813989 |
| the trh stimulation test in endemic goitre in greece. | the serum t4=t4(d), t3 in vitro uptake=rt3u and tsh were measured before and 30 min after the injection of 200 mug of trh in 30 subjects from an iodine deficient area of central greece. these persons were divided in two groups of 16 goitrous and 14 nongoitrous patients and the results from each group compared to each other and also with the same parameters obtained from 14 controls subjects, all nongoitrous and from a nonendemic area. it has been found that in this area with a mild iodine defici ... | 1976 | 814367 |
| acute redistribution of thyroxine after the administration of univalent anions, salicylate, theophylline and barbiturates in rats. | rats were injected with [125i]l-thyroxine (t4) ip 16 h before the experiment and samples of blood were frequently taken from polyethylene tubing inserted into the femoral artery in anaesthetized and heparin injected animals, isovolaemia being maintained. in each sample of plasma t4 counts per ml were estimated with the aid of paper chromatography. rapid decrease of circulating t4 level was found at 20 min after iv injection of various compounds (thiocyanate, iodide, fluoroborate, theophylline an ... | 1976 | 814764 |
| [the effect of iodide on the trh-induced release of htsh, t4 and t3 in euthyroid subjects (author's transl)]. | prolonged administration of 25 mg iodide per day to euthyroid subjects caused an increased release of htsh in response to the i.v. administration of trh. this effect was significant (p less than 0.01) intraindividually in eight out of nine subjects. the maximum serum htsh level was observed twenty minutes after the administration of trh. it reached 8.0 +/- 1.7 muu/ml during the control period and increased to 11.6 +/- 1.6 muu/ml after two weeks of 25 mg iodide per day. basal serum concentrations ... | 1975 | 816092 |
| the thyroid in ulcerative colitis and crohn's disease. v. triiodothyronine. effect of corticosteroids and influence of severe disease. | the concentrations of triiodothyronine (t3), thyroxine (t4) and thyroxine binding globulin (tbg) have been measured in serum of 20 patients with ulcerative colitis or crohn's disease. the patient group was compared with 20 healthy control subjects matched for sex and age. the concentration of t3 and t4 were similar in the two groups but tbg in serum was higher in the patient group, mainly due to the high tbg levels in the female patients. the concentration of t3 in serum was lower in the severel ... | 1976 | 816175 |
| enchanced in vitro hepatic glucuronidation of thyroxine in rats following cutaneous application or ingestion of polychlorinated biphenyls. | in rats four daily skin application of a 30% solution of a polychlorinated biphenyl (pcb) mixture in mineral oil or of a microscope immersion oil, containing 34% pcb, led to increases in liver weight, protein concentration of the 10 000 x g supernatant fluid of liver homogenates and the in vitro glucuronidation of thyroxine (t4) by the supernatant fluid, whether related to liver weight or to protein concentration in the reaction mixture. similar effects occurred after feeding 250 ppm (mg/kg) of ... | 1976 | 816436 |
| natural history and survival of inoperable breast cancer treated with radiotherapy and radiotherapy followed by radical mastectomy. | this retrospective study evaluates the time and site of relapse as well as the median survival of 454 consecutive patients with t3-t4 nx mo breast cancer treated with radiation therapy from 1968 to 1972. radiotherapy was delivered with kilovoltage to the first 221 patients and with cobalt to 233 patients, respectively. a group of 133 selected patients was subjected to radical mastectomy 6-8 weeks after completion of the irradiation. the incidence of first relapse was 45% within the first 18 mont ... | 1976 | 816452 |
| suppression of thyrotropic hormone secretion by prostaglandin synthesis inhibitors. | in order to determine whether endogenous prostaglandins (pgs) are involved in the secretion of thyrotropic hormone (tsh), we monitored plasma tsh levels in female rats receiving indomethacin (ind) or aspirin (asp) to inhibit pg synthesis. tsh secretion was induced by either exogenous thyrotropin-releasing hormone (trh) or by throidectomy. on the basis of preliminary experiments, ind was found to inhibit thyroid secretion directly. subsequently, thyroidectomized rats receiving thyroxine (t4) repl ... | 1976 | 816639 |
| alterations in thyroxine metabolism produced by cutaneous application of microscope immersion oil: effects due to polychlorinated biphenyls. | a 30% solution of a polychlorinated biphenyl (pcb) mixture or a microscope immersion oil containing 34% pcb, when applied to the skin of rats, led to substantial increases in the biliary excretion of intravenously injected [125i]thyroxine (t4) in bile: plasma 125i ratios, in the biliary clearance rate of plasma [125i]t4, and in bile flow. both pcb preparations also elevated liver weight, thyroid 125i uptake, and sephadex uptake of [125i]triiodothyronine (t3), and depressed serum t4 concentration ... | 1976 | 816641 |
| paradoxical modulation of thyrotrope responsiveness to trh during the treatment of thyrotoxic patients: apparent absence of feed-back regulation. | eight patients with active thyrotoxicosis have been followed up to one year after the onset of antithyroid treatment. at different time intervals during the investigation period, trh tests were performed and total t4 and t3 basal levels were measured. the trh-induced tsh release was delayed in all patients in spite of a normalization of the circulating levels of thyroid hormones. the delay varied according to the patients and lasted, in some cases, for as long as 24 weeks after the normalization ... | 1976 | 816723 |
| specificity of bacterial ribosomes and messenger ribonucleic acids in protein synthesis reactions in vitro. | ribosomes from two gram-negative bacteria translated f2 rna, t4 early mrna, mrna from three gran-negative bacteria, and mrna from six gram-positive bacteria; ribosomes from three gram-positive bacteria translated mrna from the gram-positive strains, but did not translate the other mrnas. ribosomes from the gram-negative bacterium escherichia coli translated synthetic poly(u,g) but ribosomes from the gram-positive bacterium clostridium pasteurianum translated poly(u,g) very poorly, mrna from gram ... | 1976 | 816792 |
| increased free thyroxine in a euthyroid patient with thyroxine-binding globulin deficiency. | an unusual finding of elevated free thyroxine (ft4) concentration coexistent with familial low thyroxine-binding globulin (tbg) is described in a euthyroid patient. clinical and other laboratory tests were normal and consistent with a clinical diagnosis of euthyroidism. low tbg (tbg capacity 3-10 mug/100 ml) was confirmed by various electrophoretic procedures and by tbg immunoassay (0.9 mg/100 ml). serum t4 concentration was low (2.0-5.5 mug/100 ml). triiodothyronine (t3) resin uptake was increa ... | 1976 | 816806 |
| low setting of feedback regulation of tsh secretion by thyroxine in pituitary dwarfism with tsh-releasing hormone deficiency. | four patients with idiopathic pituitary dwarfism were shown to have growth hormone (gh), adrenocorticotropin (acth), and luteinizing hormone (lh) deficiencies. basal levels of thyrotropin (tsh) were within normal range in three patients and slightly elevated in one. exaggerated and delayed responses were obtained after tsh-releasing hormone (trh) stimulation. serum thyroxine (t4) values were low (2.3 +/- 0.4 mug/100 ml), while triiodothyronine (t3) levels were in the normal range (1.22 +/- 0.25 ... | 1976 | 816807 |
| observations on the untreated progeny of hypothyroid male rats. | the untreated progeny (f1) of hypothyroid male rats that were either radiothyroidectomized (tx) or had the neo-t4 syndrome (an endocrine disorder produced by large doses of thyroxine (t4) injected during the neonatal period) were studied. the mother rats were all normal. the fathers never had any contact with their progeny. unexpectedly, the progeny usually showed delayed eye opening, decreased weaning weights, and increased final body weight. the thyroid glands from f1 offspring of both tx and ... | 1976 | 817106 |
| [use of radioisotope technics for determination of thyroid hormones. research on blood and urine]. | at first the aa. present the recent progresses reached in the endocrinology diagnostic with the aid of the radioisotopic techniques; successively they refer about the principles regulating the chemical reactions used in the dosage of the single hormones and about the use of index interesting the clinical practice. the aa. compare the methods of dosage used in the kits of various firms outlining the problems concerning the technological times, the operations number, the contamination risk. they p ... | 1975 | 817354 |
| the tsh response to thyrotropin-releasing hormone (trh) in young adult men: intra-individual variation and relation to basal serum tsh and thyroid hormones. | the response of serum tsh to duplicate tests with each of two doses of trh (30 mug and 500 mug) was studied in 22 normal young adult men. the mean intra-individual variability of the response assessed by duplicate testing (coefficient of variation) was 17% but was as high as 63% in individual subjects. while the actual range of peak tsh values after 500 mug trh was 2.7-19.5 muu/ml, those subjects (3 of 22) with a peak tsh value between 2 and 5 muu/ml on one occasion were all greater than 5 muu/m ... | 1976 | 818102 |
| simultaneous measurement of percentage free thyroxine and triiodothyronine: comparison of equilibrium dialysis and sephadex chromatography. | an equilibrium dialysis technique was used to measure simultaneously the proportion of free thyroxine (%ft4) and free 3,4,5'-triiodothyronine (%ft3) in sera from patients with diverse states of thyroid function and abnormal levels of plasma t4-binding proteins. in general, the correlation between %ft4 and %ft3 values was excellent in the entire group of patients studied. studies were also conducted to ascertain whether sephadex columns could be employed to obtain simultaneous measures of plasma ... | 1976 | 818346 |
| selective messenger translation by bacillus subtilis ribosomes. | the in vitro b. subtilis protein synthesizing system is very restricted in its ability to translate e. coli phage messenger rna's, specifically phage t4 rna, even though it actively translates its proper mrna species. in contrast, the e. coli system translates with similar efficiency mrna from either source. the initiation factors from the two systems are functionally interchangeable. the 30s b. subtilis ribosomal subunit is responsible for the limited template specificity of the b. subtilis rib ... | 1976 | 818501 |
| [changes in the binding capacity of thyroxine-binding globulin (tbc), of total thyroxine (t4), of the free thyroxine index (ft4-i) and of thyrotropin (tsh) during normal pregnancy and in hydatidiform mole]. | tbc-index and total serum thyroxine were measured in 100 healthy nonpregnant and in 163 pregnant women during the 8. and 41. weeks of gestation. the free thyroxine index was calculated. the tbc-index was found to be elevated in pregnant women and rose continously with duration of pregnancy. the amount of total serum thyroxine was greater in pregnant women (p less than 0,01) without difference between early and late pregnancy. the free thyroxine index decreased continously during pregnancy (p les ... | 1975 | 818851 |
| effects of hyperthyroidism and hypothyroidism on rat growth hormone release induced by thyrotropin-releasing hormone. | the effect of synthetic thyrotropin-releasing hormone (trh) on the release of growth hormone (gh) and thyroid-stimulating hormone (tsh) was investigated in euthyroid, hypothyroid, and hyperthyroid rats under urethane anesthesia. in euthyroid control rats, intravenous injection of trh (200 ng/100 g bw) resulted in a significant increase in both plasma gh and tsh. in rats made hypothyroid by treatment with propylthiouracil or by thyroidectomy, basal gh and tsh levels were significantly elevated wi ... | 1976 | 819251 |
| on the time course of thyrotropin suppression by high doses of thyroid hormones. | basal and stimulated tsh decreased progressively. basal tsh was suppressed below the detection limit of 0.4 muu/ml after 74 h in 2 of the t3 and all of the t4 treated individuals. at this time in both groups 3 individuals could be significantly stimulated by trh (abour 5% of the pretreatment stimulation). there was no significant difference in the time course of suppression obtained by t3 or t4 through plasma t3 levels in the t4 treated group were considerably lower. | 1976 | 819291 |
| [measurement of thyroxine binding globulin by competitive ligand binding assay (clba) (author's transl)]. | the competitive ligand binding assay (clba) first described by chopra et al. ((1972) j. clin. endocrinol. metab. 35, 565-573) is a convenient routine method for the accurate measurement of thyroxine binding globulin in large numbers of serum samples. the assay is based on the partition of a constant quantity of radiolabelled t3 between a fixed quantity of rabbit t3 antibodies and the thyroxine binding globulin of the serum, after prior removal of t3 and t4 from the serum with an anion exchange r ... | 1976 | 819614 |
| [restitution of the thyrotropic function in goiter patients after discontinuing a long-term suppression therapy with thyroid hormones]. | 27 subjects with a negative trh test were selected among patients with euthyroid goiter treated by thyroid hormones. the hormone therapy was stopped and t3 and t4 concentrations, basal and trh stimulated tsh levels were determined after one, two and four weeks. a gradual increase of the mean basal and trh stimulated tsh plasms concentration could be observed. however, after four weeks the trh test was still negative in two patients and weak positive in another case. t3 plasma levels were lowest ... | 1976 | 819709 |
| the chick embryo in studies of virulence and immunity with neisseria gonorrhoeae. | intravenous inoculation of 11-day old chick embryos with neisseria gonorrhoeae has confirmed the original observation of bumgarner and finkelstein that t1 and t2 gonocci are significantly more virulent than t3 and t4. pili do not seem to be solely responsible for this virulence, since elimination of pili did not effect either the viability or the virulence of n. gonorrhoeae. in neutralization studies, there was only one log difference between the ability of normal and hyperimmune rabbit serum to ... | 1975 | 819971 |
| measurements of free and total serum t3 and t4 in pregnant subjects and in neonates. | despite recent descriptions of dramatic changes in the thyroidal economy in pregnancy, the precise mechanisms of these alterations have remained obscure. measurements of total and free triiodothyronine (t3) and thyroxine (t4) and thyroxine binding capacity (tbg) were made in 120 serum samples from 42 first trimester, 55 second trimester, and 23 third trimester pregnant women. sixteen paired term and cord blood samples were also analyzed. mean total serum t4 rose progressively from 9.8 in the fir ... | 1976 | 820197 |
| time, dose, and tumor volume relationships in irradiation of squamous cell carcinomas of the base of the tongue. | between january 1954 and august 1971, 174 patients with squamous cell carcinoma of the base of the tongue were treated with megavoltage external beam using conventional treatment times. since the cumulative recurrence rate was 90% by 2 years, patients surviving 2 years without primary recurrences are considered to have no evidence of disease (ned) at the primary site. the primary control rate for t1 lesions is over 90% for doses of 6000 rads in 6 weeks to 6500 rads in 6 1/2 weeks. the control ra ... | 1976 | 820418 |
| carcinoma of the nasopharynx. eighteen years' experience with megavoltage radiation therapy. | from 1956 through 1973, 82 patients with carcinoma of the nasopharynx received high dose megavoltage radiation therapy at stanford university. the actuarial disease-free (ned) survival was 62% at 5 years and 56% at 10 years. the ned survivals at 5 years for patients with t1, t2, and t3 lesions were 76%, 68%, and 55%, respectively. no t4 patients were salvaged, but two of 10 patients who presented with cranial nerve dysfunction were long-term survivors. the degree of nodal involvement also had pr ... | 1976 | 820419 |
| radioimmunoassay of thyroxine-binding globulin in human plasma. | a highly specific and precise radioimmunoassay for thyroxine-binding globulin (tbg) has been developed. crossreactivity with albumin and prealbumin was excluded. the normal range in young adults was 0.97 mg/100 ml. in childhood tbg was elevated (1.34 mg/100 ml) also in old age (1.28 mg/100 ml). in normals and in childhood there was a good correlation of tbg with thyroxine (t4). t4 did not correlate with tbg with regard to age. triiodothyroxine (t3) did not correlate with tbg in any group. t4 and ... | 1976 | 820495 |
| the effect of aspirin and indomethacin on the trh response in man. | a double-blind study of the effect of two inhibitors of prostaglandin synthesis on the trh stimulation of serum tsh and prolactin was carried out in 35 normal males. the subjects were evaluated before and after the administration of indomethacin or aspirin for one week. both indomethacin and aspirin lowered plasma prostaglandin e and f levels significantly. indomethacin treatment had no effect on the serum tsh or prolactin response to 100 mug trh or the serum t3 and t4 levels. in contrast, aspir ... | 1976 | 820703 |
| effect of halofenate on serum thyroid hormone determinations in vitro. | halofenate has been shown to decrease thyroxine (t4) binding to thyroxine-binding globulin (tbg) in vitro. several indirect serum thyroid hormone assays are dependent on thyroid hormone binding and the results might be altered by halofenate in the serum. halofenate free acid (50-500 mug/ml) was added to serum samples in vitro, and the samples were assayed for total serum t4 by competitive protein-binding assay (cpb) and radioimmunoassay (ria), the per cent of dialyzable t4 (%ft4), total serum tr ... | 1976 | 820706 |
| the effect of glucocorticoid administration on human pituitary secretion of thyrotropin and prolactin. | in order to determine the mechanism by which glucocorticosteroids decrease the serum concentration of thyrotropin (tsh), we studied eight normal subjects before and after they received 16 mg of dexamethasone daily for 2 1/2 days. serum levels of tsh and prolactin (prl) were measured in the basal state and in response to the intravenous administration of 200 mug thyrotropin-releasing hormone (trh); t4, free t4 (ft4), t3, and free t3 (ft3) were measured before trh injection. metabolic clearance ra ... | 1976 | 820709 |
| the failure of physiologic doses of reverse t3 to effect thyroid-pituitary function in man. | reverse t3 (3,3',5'-triiodothyronine, rt3), a major product of the peripheral monodeiodination of thyroxine (t4), was administered to normal male volunteers in doses sufficient to sustain an elevated serum rt3 concentration similar to that frequently observed in patients with nonthyroidal illness. no changes in basal serum t4, t3, tsh and prolactin concentrations, nor in the t3, tsh and prolactin responses to iv trh were observed during rt3 administration. these findings suggest that physiologic ... | 1976 | 820712 |
| behavior of a temperate bacteriophage in differentiating cells of bacillus subtilis. | during the first 6 hr of sporulation, infection of bacillus subtilis by by phi105 wild type or the clear-plaque mutant phi105 c30 was nonproductive, but phage dna was trapped inside developing spores. after infection with either wild-type or mutant phage at early times of sporulation (t1-t3), phage dna entered the developing spores in a heat-stable form, which may represent integration of the phage dna into the host chromosome. phage dna in carrier spores produced by infection at later times (t4 ... | 1976 | 820875 |
| type and strain variation in induction of l forms of neisseria gonorrhoeae. | strains of neisseria gonorrhoeae were inoculated onto brain heart infusion (difco) agar supplemented with penicillin and polyvinylpyrrolidone (pvp) as a stabilizer and cultivated in a candle extinction jar. l-form colonies became visible after a few days. they continued to grow and were viable for up to 38 days. the extent of inducibility of l forms of n. gonorrhoeae was examined semiquantitatively. it was found to be constant for each type and strain and to depend only slightly on the amount of ... | 1976 | 820897 |
| thyroid function in changing weather in a subtropical region. | serum and 24-hr urine samples were collected on 2 consecutive days during the first week of each month for 1 yr from eight healthy euthyroid men aged 25-37 yr. the means of minimum and maximum environmental temperature for the 30 days period preceding the sample collection represented the temperature for that month. total serum thyroxine (t4), triiodothyronine (t3), thyrotropin (tsh), and urinary t3 and t4 were measured by specific radioimmunoassays and serum thyroxine-binding globulin (tbg) by ... | 1976 | 820939 |
| [the diencephalo-hypophyseo-thyroid axis in essential obesity. note ii. evaluation of the thyroid t4 (d) after stimulation with intravenous trh]. | | 1975 | 821500 |
| absence of high-affinity low-capacity components of t4-binding sites in the cytosol of the bullfrog tadpole. | | 1976 | 821811 |
| effect of iodine upon the trh induced release of tsh in euthyroid, hypothyroid and hyperthyroid individuals. | the effects of prolonged administration of iodide upon the serum concentrations of thyrotropin (tsh), thyroxine (t4), and triiodothyronine (t3) and their response to thyrotropin releasing hormone (trh, 400 mug i.v.) have been studied in euthyroid (n = 9) subjects, and in hypothyroid (n = 4) patients. administration of iodide (25 mg daily for two weeks) increased in healthy subjects the basal concentrations of tsh and the release of tsh in response to trh (p less than 0.05-0.01). serum concentrat ... | 1976 | 821840 |
| abnormal tsh, prl and gh response to tsh releasing factor in chronic renal failure. | tsh, prl and gh response to tsh releasing factor as well as basal t4 and t3 were evaluated in a group of patients with chronic renal failure undergoing chronic hemodialysis. serum t4 and t3 were lower than normal. basal tsh was normal as compared to control, but did not rise after trf stimulation. larger dosages of trf did not correct this abnormal response. basal prl was higher than control and remained at the same level during the test. gh was stimulated by the trf with a peak occurring 20 min ... | 1976 | 821962 |
| [cooperative survey for the determinations of l-triiodothyronine (t3) and l-thyroxine (t4): critical evaluation of methods employed (author's transl)]. | a cooperative survey of the radioimmunoassays for triiodothyronine was performed among 30 participating laboratories from the thyroid association of the german society for endocrinology. a total of 16 serum samples were sent frozen to each laboratory for the determination of both triiodothyronine (t3) and thyroxine (t4). it was possible to calculate the recovery rates of the participants from the values determined for an internal standard curve, which was hidden within the 16 samples and was mad ... | 1976 | 822120 |
| total and free thyroxine in patients with liver cirrhosis. | in 11 patients with compensated and 10 with decompensated liver cirrhosis the following determinations were carried out: total thyroxine serum concentration (t4), triiodothyronine-binding coefficient (t3bc), free thyroxine by the dialysis method (dft4), free thyroxine index (ft4i) and absolute value of free thyroxine (adft4). a statistically significant rise of t3bc, dft4, adft4 and ft4i was observed only in the group of decompensated cirrhosis. it is supposed that these changes develop not as a ... | 1976 | 822399 |
| microscopic organization of the ligamenta flava in cercopithecinae. | the ligamenta flava have been investigated in cercopithecus pygerythrus (vervet monkey) and c. mitis (blue monkey) at various levels of the vertebral column. it has been shown that in the cervical, thoracic and lumbar regions the topography of these ligaments differs. the cervical ligamenta flava do not extend over the intervertebral joints, while in the thoracic and lumbar regions they reinforce and fuse with the capsule. the ligamenta flava from t4 to s1 replace the interspinous ligaments by e ... | 1976 | 822678 |
| [thyroxine and triiodothyronine]. | the value of measurements of serum thyroxine (t4) and triiodothyronine (t3) concentrations in the clinical evaluation of thyroid function is well established. in the present report the properties of the methods currently available for the assessment of circulating thyroid hormones are examined. recent data indicate that results of measurements of serum t4 by radioimmunoassay (ria) or by displacement analysis are qualitatively and quantitatively similar. evidence has been provided from this and o ... | 1975 | 822768 |
| [studies on the trh test on the patients with graves' disease during the treatment with antithyroid drug (author's transl)]. | a study was performed to observe serum tsh response following trh injection (trh test) in 79 cases of graves' disease (male 23, female 56, aged 16-70 years old), before and during treatment by antithyroid drug, in a total of 244 occasions. treatment was mostly the daily administration of methyl-mercaptoimidazole (mmi), and in one case of propylthiouracil (ptu). trh test was conducted by i.v. administration of 500 mug synthetic trh, and subsequent 6 blood drawing until 2 hours. serum tsh was meas ... | 1975 | 823053 |
| [changes in responsivity to trh test and t3-suppression test after surgical treatment of hyperthyroidism (author's transl)]. | trh test and t3 suppression test were performed on patients with graves' disease who underwent subtotal thyroidectomy after treatment with antithyroid drugs for 2.5 approximately 5 months. on 43 or the patients, trh test was performed before, 1 week after and 1 approximately 2 months after surgery and t3 suppression test was also performed in 1 approximately 2 months post-operative period. for other 3 groups of the patients trh test was performed at 2 approximatley 6 months, 6 approximately 12 m ... | 1975 | 823054 |
| [trh and t3 suppression tests after 131i therapy of thyrotoxicosis (author's transl)]. | trh and t3 suppression tests were performed on patients (124 cases) with graves' disease who underwent radiation therapy. trh test was performed at 4-6 months (group i), 6-12 months (group ii), 12-24 months (group iii) and 24-50 months (group iv) after final radiation therapy, and t3 suppression test was performed just after each trh test. the response to trh test was defined as positive when the basal tsh value was less than 2.0 muu/ml and the peak value was more than 6.2 muu/ml following trh ( ... | 1976 | 823056 |
| effect of normalization of hypometabolic state on blood pressure in spontaneously hypertensive rats and in patients with essential hypertension. | spontaneously hypertensive rats (shr) manifest a hypothyroid state as evidenced by increased thyroid weight, an increased level of plasma thyroid-stimulating hormone (tsh) and a decreased level of plasma thyroxine (t4) and triiodothyronine (t3). in 18 patients with essential hypertension, plasma tsh, t4 and t3 concentrations were all within the normal range, but the t4 level was significantly lower than in the controls. among 21 hypothyroid patients, 2 had essential hypertension. administration ... | 1976 | 823191 |
| isolation and properties of the dna of african swine fever (asf) virus. | african swine fever (asf) virus was grown either in swine macrophages or in vero cells and purified free of cell dna. virus dna was isolated from virions as a molecule with a sedimentation coefficient of 60s and a contour of 58 +/- 3 mum. .these two values give a mol. wt. of 102 +/- 5 x 10(6) and 107 +/- 5 x 10(6), respectively, for the genome of asf virus. denatured dna fragments from asf virus reassociate with a c0t1/2 value of 0-60 +/- 0-05 ms, which compared with the corresponding value for ... | 1976 | 823295 |
| the thyroidal t4/t3 ratio and its regulation in non-toxic goitre. | in 35 patients with non-toxic goitre, surgically resected thyroid tissue was hydrolyzed with pronase under anaerobic conditions in the presence of methylmercaptoimidazole. total iodine, pbi, l-thyroxine (t4-ria and t4 (d)) as well as triiodothyronine (t3-ria) were determined in the tissue hydrolysates. the data obtained were compared with t4/t3 ratios in the serum, trh test and thyroidal 131i uptake before operation. the total iodine, amounted to 112.6 +/- 14.6 ug/g tissue. the t4/t3 ratio was 1 ... | 1976 | 824192 |
| effect of n3im-methyl-thyrotropin releasing hormone on the human pituitary-thyroid axis. | the n3im-methyl analogue of thyrotropin release hormone (methyl-trh) was compared with trh as a thyrotropin releaser in 30 euthyroid volunteers (ages 19-61 years). the mean tsh response to 100 mug of methyl-trh was greater (p less than 0.005) than the tsh response to 500 mug of trh from 10 min to 240 min after giving the releasing factors. the mean peak tsh (at 30 min), maximum deltatsh, and integrated tsh response area were greater (p less than 0.005) after administration of methyl-trh than aft ... | 1976 | 824296 |
| changes in serum thyrotropin (tsh) in man during halofenate administration. | halofenate, a serum lipid-lowering agent which inhibits binding of thyroid hormone to thyroxine-binding globulin (tbg), was administered daily for 14 days to 8 hypothyroid subjects with elevated tsh concentrations as a result of incomplete thyroxine (t4) therapy. drug administration resulted in mean increases in serum dialyzable fraction t4 (dft4) of 52% over pretreatment levels (p less than 0.01) and in dialyzable fraction triiodothyronine (dft3) of 26% in 7 subjects, (p less than 0.01). during ... | 1976 | 824301 |