| a multiplex rt-pcr assay for s. aureus, l. monocytogenes, and salmonella spp. detection in raw milk with pre-enrichment. | this study firstly developed a multiplex real-time pcr (rt-pcr) technique combined with a pre-enrichment step to simultaneously detect staphylococcus aureus (s. aureus), listeria monocytogenes (l. monocytogenes) and salmonella spp. in raw milk and the dairy farm environment (feces, soil, feed, water) in one reaction. brain heart infusion (bhi) broth was selected for the enrichment step to increase the density of the target bacteria by using an incubation of 4 h before multiplex rt-pcr. the resul ... | 2017 | 28620364 |
| development of biopolymer composite films using a microfluidization technique for carboxymethylcellulose and apple skin particles. | biopolymer films based on apple skin powder (asp) and carboxymethylcellulose (cmc) were developed with the addition of apple skin extract (ase) and tartaric acid (ta). asp/cmc composite films were prepared by mixing cmc with asp solution using a microfluidization technique to reduce particle size. then, various concentrations of ase and ta were incorporated into the film solution as an antioxidant and an antimicrobial agent, respectively. fourier transform infrared (ftir), optical, mechanical, w ... | 2017 | 28617325 |
| relating physicochemical and microbiological safety indicators during processing of linguiça, a portuguese traditional dry-fermented sausage. | linguiça is a portuguese traditional fermented sausage whose microbiological quality and safety can be highly variable. in order to elucidate risk factors and the particularities of the manufacturing technology that explain the between-batch variability in total viable counts (tvc), enterobacteriaceae, staphylococcus aureus and listeria monocytogenes in the product; microbiological and physicochemical characterisation of linguiça at five stages of production (i.e., raw pork meat, mixed with ingr ... | 2015 | 28433317 |
| antimicrobial and anti-inflammatory effects of ethanol extract of corylopsis coreana uyeki flos. | corylopsis coreana uyeki (hamamelidaceae) is a medicinal plant cultivated in northeast asia. previously, we have reported that an ethanol extract of corylopsis coreana uyeki flos (eccf) contains four active compounds with antioxidant activity. | 2017 | 28539723 |
| formulation, characterization and properties of hemp seed oil and its emulsions. | the formulation, characterization, and anticipated antibacterial properties of hemp seed oil and its emulsions were investigated. the oil obtained from the seeds of cannabis sativa l. in refined and unrefined form was characterized using iodine, saponification, acid values, and gas chromatography, and was employed for the preparation of stable oil-in-water emulsions. the emulsions were prepared using pairs of non-ionic surfactants (tween, span). the effects of the emulsification method (spontane ... | 2017 | 28448475 |
| treatment challenges of group a beta-hemolytic streptococcal pharyngo-tonsillitis. | introduction despite its in vitro efficacy, penicillin often fails to eradicate group a β-hemolytic streptococci (gabhs) from patients with acute and relapsing pharyngo-tonsillitis (pt). objective this review of the literature details the causes of penicillin failure to eradicate gabhs pt and the therapeutic modalities to reduce and overcome antimicrobial failure. data synthesis the causes of penicillin failure in eradicating gabhs pt include the presence of β lactamase producing bacteria (bl ... | 2017 | 28680500 |
| colonisation of antibiotic resistant bacteria in a cohort of hiv infected children in ghana. | antibiotic use not only selects for resistance in pathogenic bacteria, but also in commensal flora of exposed individuals. little is known epidemiologically about antibiotic resistance in relation to people with hiv infection in sub-saharan africa. this study investigated the carriage of antibiotic resistant bacteria among hiv infected children at a tertiary hospital in ghana. one hundred and eighteen hiv positive children were recruited at the korle-bu teaching hospital in ghana and nasopharyng ... | 2017 | 28451037 |
| chemical modification and detoxification of the pseudomonas aeruginosa toxin 2-heptyl-4-hydroxyquinoline n-oxide by environmental and pathogenic bacteria. | 2-heptyl-4-hydroxyquinoline n-oxide (hqno), a major secondary metabolite and virulence factor produced by the opportunistic pathogen pseudomonas aeruginosa, acts as a potent inhibitor of respiratory electron transfer and thereby affects host cells as well as microorganisms. in this study, we demonstrate the previously unknown capability of environmental and pathogenic bacteria to transform and detoxify this compound. strains of arthrobacter and rhodococcus spp. as well as staphylococcus aureus i ... | 2017 | 28708374 |
| a new pyranonaphtoquinone derivative, 4-oxo-rhinacanthin a, from roots of indonesian rhinacanthus nasutus. | a new pyranonaphthoquinone derivative, named 4-oxo-rhinacanthin a (1), was isolated from the roots of the indonesian rhinacanthus nasutus together with two known congeners, rhinacanthin a (2) and 3,4-dihydro-3,3-dimethyl-2h-naphtho[2,3-b]pyran-5,10-dione (3). the structure of 1 was elucidated based on its spectroscopic data. the absolute configuration of 1 was assigned by comparing its experimental electronic circular dichroism (ecd) spectrum with the calculated ecd spectrum. compounds 2 and 3 i ... | 2017 | 28566651 |
| preclinical assessment of a (68)ga-dota-functionalized depsipeptide as a radiodiagnostic infection imaging agent. | the study assessed a radiolabeled depsipeptide conjugate ((68)ga-dota-tbia101) for its potential as an imaging agent targeting infection or infection-associated inflammation. (68)ga-labeled dota-tbia101 imaging was performed in (nzr1) healthy rabbits; (nzr2) rabbits bearing muscular sterile inflammation and staphylococcus aureus (sa) infection; and (nzr3) rabbits infected with mycobacterium tuberculosis (mtb) combined with a subcutaneous scruff infection of sa in the same animal. all animals wer ... | 2017 | 28837117 |
| in vitro activity of alpha-viniferin isolated from the roots of carex humilis against mycobacterium tuberculosis. | this study explores the antitubercular activity of α-viniferin, a bioactive phytochemical compound obtained from carex humilis. α-viniferin was active against both drug-susceptible and -resistant strains of mycobacterium tuberculosis at mic50s of 4.6 μm in culture broth medium and mic50s of 2.3-4.6 μm inside macrophages and pneumocytes. in combination with streptomycin and ethambutol, α-viniferin exhibited an additive effect and partial synergy, respectively, against m. tuberculosis h37rv. α-vin ... | 2017 | 28782713 |
| teixobactin and its analogues: a new hope in antibiotic discovery. | increasing bacterial resistance against current antibiotics and lack of new molecules to combat bacterial resistance are key challenges to global health. there is, therefore, a continuing need to develop new antibiotics. teixobactin, a cyclic undecapeptide, displays excellent antibacterial activities against a range of pathogenic bacteria, such as methicillin-resistant staphylococcus aureus (mrsa) and mycobacterium tuberculosis. interestingly, it operates by multiple modes of actions and is bact ... | 2017 | 28770988 |
| plant-derived antimicrobials to fight against multi-drug-resistant human pathogens. | antibiotic resistance is becoming a pivotal concern for public health that has accelerated the search for new antimicrobial molecules from nature. numbers of human pathogens have inevitably evolved to become resistant to various currently available drugs causing considerable mortality and morbidity worldwide. it is apparent that novel antibiotics are urgently warranted to combat these life-threatening pathogens. in recent years, there have been an increasing number of studies to discover new bio ... | 2017 | 28660459 |
| antimicrobial investigation of selected soil actinomycetes isolated from unexplored regions of kashmir himalayas, india. | the aim of the present study was to isolate and evaluate the antimicrobial potential of soil actinomycetes of kashmir himalayas. the secondary metabolites of actinomycetes are the prominent source of antibiotics. a total of 121 morphologically different actinomycete strains were isolated and screened for antimicrobial activity against various human pathogens. the ethyl acetate extract of fermented broth an actinomycete strain, identified as streptomyces pratensis exhibited significant antimicrob ... | 2017 | 28647504 |
| copper and antibiotics: discovery, modes of action, and opportunities for medicinal applications. | copper is a ubiquitous element in the environment as well as living organisms, with its redox capabilities and complexation potential making it indispensable for many cellular functions. however, these same properties can be highly detrimental to prokaryotes and eukaryotes when not properly controlled, damaging many biomolecules including dna, lipids, and proteins. to restrict free copper concentrations, all bacteria have developed mechanisms of resistance, sequestering and effluxing labile copp ... | 2017 | 28528648 |
| pyopericardium with cardiac tamponade in a nigerian child with acute osteomyelitis. | in pyopericardium, pus accumulates in the pericardial space as a result of infection by pyogenic organisms, most common of which are staphylococcus aureus and mycobacterium tuberculosis. these patients are at risk of cardiac tamponade. apart from pericardiocentesis in the management of these patients, definitive drug treatment may pose a formidable challenge in a setting of coinfection as in patients with tuberculosis who are predisposed to secondary bacterial infections. this was the case of ou ... | 2017 | 28465998 |
| endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron. | the iron-regulatory hormone hepcidin is induced early in infection, causing iron sequestration in macrophages and decreased plasma iron; this is proposed to limit the replication of extracellular microbes, but could also promote infection with macrophage-tropic pathogens. the mechanisms by which hepcidin and hypoferremia modulate host defense, and the spectrum of microbes affected, are poorly understood. using mouse models, we show that hepcidin was selectively protective against siderophilic ex ... | 2017 | 28465342 |
| mycobacterium tuberculosis infection at pacemaker implantation site. | expanding clinical indications of cardiac rhythm management have led to an increased use of pacemaker implantation which is associated with increased incidence of pacemaker infections. staphylococcus aureus and epidermidis account for the majority of pacemaker infections. infection of implantable cardiac devices by mycobacterium species, particularly mycobacterial tuberculosis is rare. we present a case of delayed pacemaker pocket infection with tuberculosis and review of literature of pacemaker ... | 2017 | 28457043 |
| virulence potential of staphylococcus aureus isolates from buruli ulcer patients. | buruli ulcer (bu) is a necrotizing infection of the skin and subcutaneous tissue caused by mycobacterium ulcerans. bu wounds may also be colonized with other microorganisms including staphylococcus aureus. this study aimed to characterize the virulence factors of s. aureus isolated from bu patients. previously sequenced genomes of 21 s. aureus isolates from bu patients were screened for the presence of virulence genes. the results show that all s. aureus isolates harbored on their core genomes g ... | 2017 | 28442219 |
| cathelicidin production and release by mammary epithelial cells during infectious mastitis. | cathelicidins are well-characterized antimicrobial peptides (amps) that are present in significant amounts in mastitic milk. neutrophils are believed to be the main producers of these amps, while the role of mammary epithelial cells (mecs) in their production and release is still unclear. in this work, cathelicidin production patterns were investigated in mammary tissues of ewes infected by staphylococcus aureus, streptococcus uberis, or mycoplasma agalactiae, with a combined approach including ... | 2017 | 28669389 |
| within-herd prevalence of intramammary infection caused by mycoplasma bovis and associations between cow udder health, milk yield, and composition. | subclinical mastitis is one of the major health problems in dairy herds due to decreased milk production and reduced milk quality. the aim of this study was to examine the within-herd prevalence of subclinical intramammary infection caused by mycoplasma bovis and to evaluate associations between m. bovis and cow daily milk yield, udder health, and milk composition. individual cow composite milk samples (n = 522) were collected from all lactating dairy cows in 1 estonian dairy farm in november 20 ... | 2017 | 28601455 |
| synthesis and biological evaluation of novel thioether pleuromutilin derivatives. | to develop new pleuromutilin derivatives as veterinary antibiotic medicines, we designed and synthesized a series of new thioether pleuromutilin derivatives possessing acylthiazolyl moiety based on previously designed derivatives. the antibacterial properties of the prepared pleuromutilin derivatives were assessed in vitro by the broth dilution method against five kinds of bacteria and the mycoplasma mycoplasma gallisepticum (mg). all of the tested compounds displayed moderate to good antibacter ... | 2017 | 28768998 |
| a rapid, low-cost, and microfluidic chip-based system for parallel identification of multiple pathogens related to clinical pneumonia. | an air-insulated microfluidic chip was designed for the automatic centrifugal distribution of samples to 24-test cells, enabling the parallel identification of multiple clinical pneumonia-related pathogens in 1.45-μl reactions without cross-contamination in 45 min. a portable nucleic acid analyzer that integrates mechanical, confocal optical, electronic, and software functions was also developed to collect fluorescence data in a ø3 mm imaging field near the optical diffraction limit for highly s ... | 2017 | 28743917 |
| prevalence of mycoplasma pneumoniae infection in malagasy children. | childhood community-acquired pneumonia is a leading cause of childhood morbidity in low-income countries. the etiologic agents are usually staphylococcus aureus, streptococcus pneumoniae and mycoplasma pneumoniae. m. pneumoniae was recognized as a cofactor in asthmatic disease. high asthma prevalence was reported in madagascar. our aim was to clarify the prevalence of m. pneumoniae infection in this country and its relationship with asthma. | 2017 | 28403048 |
| role of fatty acid kinase in cellular lipid homeostasis and saers-dependent virulence factor expression in staphylococcus aureus. | the saers two-component system is a master activator of virulence factor transcription in staphylococcus aureus, but the cellular factors that control its activity are unknown. fatty acid (fa) kinase is a two-component enzyme system required for extracellular fa uptake and saers activity. here, we demonstrate the existence of an intracellular nonesterified fa pool in s. aureus that is elevated in strains lacking fa kinase activity. saers-mediated transcription is restored in fa kinase-negative s ... | 2017 | 28765222 |
| synthesis and biological evaluation of novel 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines as potential anti-bacterial agents. | a facile two-step synthetic approach to fluorinated and non-fluorinated 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines from readily available 5-bromo-4-(furan-2-yl)pyrimidine has been developed. all synthesized compounds were screened in vitro for their antibacterial activities against twelve various bacterial strains. it is demonstrated that some of these compounds exhibited significant antibacterial activities against strains neisseria gonorrhoeae and staphylococcus aureus, comparable and even highe ... | 2017 | 28512023 |
| culture-proven thorn-associated infections in arizona: 10-year experience at mayo clinic. | thorn injuries are common in the desert southwest; however, the frequency and microbiology of thorn-associated infections have not been systematically described. most information comes from case reports describing infections from atypical or environmental microorganisms. our aim was to summarize the spectrum of thorn-associated infections. | 2017 | 28480288 |
| isolation, characterization, virulence and immunogenicity testing of field isolates of pasteurella multocida, staphylococcus aureus, and streptococcus agalactiae in laboratory settings. | the present study was designed to investigate isolation, characterization, virulence and immunogenicity testing of field isolates of pasteurella multocida, staphylococcus aureus, and streptococcus agalactiae in rabbits and mice. isolates of p. multocida, s. aureus and str. agalactiae recovered from field cases of hemorragic septicemia and mastitis were scrutinized for virulence/pathogenicity and immunogenicity. mouse ld50 of p. multocida showed that p. multocida isolate no.1 was more virulent th ... | 2017 | 28450213 |
| cryostored autologous skull bone for cranioplasty? a study on cranial bone flaps' viability and microbial contamination after deep-frozen storage at -80°c. | craniectomy is a life-saving procedure. subsequent cranioplasty with autologous skull bone has a bone resorption rate from 4% to 22.8% and an infection rate from 3.3% to 26%. there are concerns with their viability and the potential microbial contamination as they were explanted for a long period of time. eighteen cranial bone flaps stored at prince of wales hospital skull bone bank during the period from june 2011 to march 2016 were identified. ethics approval was obtained. bone chips and deep ... | 2017 | 28431953 |
| in vitro and in silico antidiabetic and antimicrobial evaluation of constituents from kickxia ramosissima (nanorrhinum ramosissimum). | background and aims:kickxia ramosissima (wall.) janch (or nanorrhinum ramosissimum (wall.) betsche is a well-known medicinal plant in pakistan that is traditionally used in diabetic and inflammatory conditions. because little information is available on its phytochemical composition, a range of constituents were isolated and evaluated in vitro in assays related to the traditional use. methods: dried whole plant material was extracted and chromatographically fractionated. isolated constituents we ... | 2017 | 28507520 |
| microbiome and microbial biofilm profiles of peri-implantitis: a systematic review. | this systematic review assesses the microbiological profiles of peri-implantitis, periodontitis and healthy implants based on studies that evaluated microbial biofilms and entire microbiomes to establish their similarities and differences. | 2017 | 28625077 |
| involvement of cell surface 90 kda heat shock protein (hsp90) in pattern recognition by human monocyte-derived macrophages. | heat shock proteins (hsps) are typical intracellular chaperones which also appear on the cell surface and in extracellular milieu. hsp90, which chaperones many proteins involved in signal transduction, is also a regular component of lps-signaling complexes on mϕ. as lps is a prototypical pamp, we speculated that hsp90 is engaged in pattern recognition by professional phagocytes. in this report, we provide the first evidence, to our knowledge, of the geldanamycin (ge)-inhibitable hsp90 on the sur ... | 2017 | 28550115 |
| septic arthritis of the pubis symphysis: clinical and therapeutic features. | septic arthritis of the pubis symphysis is rare and difficult to diagnose. the objective of our study was to describe the biological, clinical, radiological and therapeutic aspects of this disease. this is a retrospective study of 4 cases of septic arthritis of the pubic symphysis collected in the department of rheumatology and orthopaedics in sousse in tunisia over a period of 16 years (2000-2016). our population consists of 3 women and one men. the mean age was 47 years (18-83). clinical signs ... | 2017 | 28690730 |
| superficial swab versus deep-tissue biopsy for the microbiological diagnosis of local infection in advanced-stage pressure ulcers of spinal-cord-injured patients: a prospective study. | to assess the predictive value of superficial ulcer swab culture to make a microbiological diagnosis of deep wound infections in spinal cord injury (sci) patients with advanced-stage pressure ulcers. | 2017 | 28433727 |
| multipurpose efficacy of zno nanoparticles coated by the crustacean immune molecule β-1, 3-glucan binding protein: toxicity on hepg2 liver cancer cells and bacterial pathogens. | the effective treatment of cancer and bacterial pathogens are two key challenges in modern nanomedicine. here, zinc oxide nanoparticles (zno nps) were fabricated using the crustacean immune molecule β-1, 3- glucan binding protein (phβ-gbp, 100kda) purified from the heamolymph of paratelphusa hydrodromus. β-gbp coated zinc oxide nanoparticles (phβ-gbp-zno nps) were characterized by uv-vis spectroscopy, x-ray diffraction (xrd), fourier transform infrared spectroscopy (ftir), and high resolution-tr ... | 2017 | 28704712 |
| the risk of cardiac device-related infection in bacteremic patients is species specific: results of a 12-year prospective cohort. | the species-specific risk of cardiac device-related infection (cdri) among bacteremic patients is incompletely understood. | 2017 | 28852678 |
| a broad range quorum sensing inhibitor working through srna inhibition. | for the last decade, chemical control of bacterial virulence has received considerable attention. ajoene, a sulfur-rich molecule from garlic has been shown to reduce expression of key quorum sensing regulated virulence factors in the opportunistic pathogen pseudomonas aeruginosa. here we show that the repressing effect of ajoene on quorum sensing occurs by inhibition of small regulatory rnas (srna) in p. aeruginosa as well as in staphylococcus aureus, another important human pathogen that employ ... | 2017 | 28851971 |
| empirical antibiotic treatment in diabetic foot infection: a study focusing on the culture and antibiotic sensitivity in a population from southern china. | diabetic foot and subsequent diabetic ulcer infections are the most devastating complication of diabetes. this study was conducted to explore the bacterial spectrum, sensitivity of microbials, and analysis of the empirical antibiotic regimens in our health center. the study included patients with diabetic foot ulcer infection (dfi) seen from 2009 to 2014. the patients included had all information covering the physical examination, laboratory tests, and image examinations. we sent appropriately o ... | 2017 | 28836481 |
| novel nitroaniline-cellulose nanohybrids: nitro radical photo-release and its antibacterial action. | in this study, carboxylated nanocrystalline cellulose is surface functionalized by a chromophoric nitro radical (no) photodonor via covalent bonding. the resulting new photoactive nanohybrid material displays an effective photogeneration of no radicals upon illumination by light. the release of no radicals has been chemically detected by various spectroscopic techniques. the bactericidal activity of the novel nanohybrid is effectively demonstrated against both gram positive (staphylococcus aureu ... | 2017 | 28821033 |
| pro- and anti-inflammatory responses of peripheral blood mononuclear cells induced by staphylococcus aureus and pseudomonas aeruginosa phages. | the ability of bacteriophages to kill bacteria is well known, as is their potential use as alternatives to antibiotics. as such, bacteriophages reach high doses locally through infection of their bacterial host in the human body. in this study we assessed the gene expression profile of peripheral blood monocytes from six donors for twelve immunity-related genes (i.e. cd14, cxcl1, cxcl5, il1a, il1b, il1rn, il6, il10, lyz, socs3, tgfbi and tnfa) induced by staphylococcus aureus phage isp and four ... | 2017 | 28808331 |
| axially substituted silicon(iv) phthalocyanine and its quaternized derivative as photosensitizers towards tumor cells and bacterial pathogens. | axially di-(alpha,alpha-diphenyl-4-pyridylmethoxy) silicon(iv) phthalocyanine (3) and its quaternized derivative (3q) were synthesized and tested as photosensitizers against tumor and bacterial cells. these new phthalocyanines were characterized by elemental analysis, and different spectroscopic methods such as ft-ir, uv-vis, maldi-tof and (1)h nmr. the photophysical properties such as absorption and fluorescence, and the photochemical properties such as singlet oxygen generation of both phthalo ... | 2017 | 28807573 |
| oxidative damage to pseudomonas aeruginosa atcc 27833 and staphylococcus aureus atcc 24213 induced by cuo-nps. | the cytotoxicity of nanoparticles (nps) and their properties are important issues in nanotechnology research. particularly, nps affect the metabolism of microorganisms due to np interactions with some biomolecules. in order to assess the mechanisms underlying nps toxicity, we studied the damage caused by copper oxide nanoparticles (cuo-nps) on staphylococcus aureus atcc 24213 and pseudomonas aeruginosa atcc 27833. spherical cuo-nps characterized by their diameter (13 ± 3 nm) were synthesized wit ... | 2017 | 28791555 |
| evaluation of bactericidal and anti-biofilm properties of a novel surface-active organosilane biocide against healthcare associated pathogens and pseudomonas aeruginosa biolfilm. | healthcare acquired infections (hai) pose a great threat in hospital settings and environmental contamination can be attributed to the spread of these. de-contamination and, significantly, prevention of re-contamination of the environment could help in preventing/reducing this threat. goldshield (gs5) is a novel organosilane biocide marketed as a single application product with residual biocidal activity. we tested the hypothesis that gs5 could provide longer-term residual antimicrobial activity ... | 2017 | 28787014 |
| electrophoretic deposition of mgo nanoparticles imparts antibacterial properties to poly-l-lactic acid for orthopedic applications. | bacterial infection of implanted biomaterials is a serious problem that increases health care costs and negatively affects a considerable fraction of orthopedic procedures. in this field, magnesium oxide nanoparticles (mgo nps) have emerged as a promising material to combat bacterial infection while maintaining or improving bone cell functions. here, mgo nps were electrophoretically deposited onto poly-l-lactic acid (plla) sheets to achieve a coating of highly exposed mgo nps that directly influ ... | 2017 | 28782240 |
| regional differences in antibiotic-resistant pathogens in patients with pneumonia: implications for clinicians. | antibiotic resistance is of great concern for both infection control and the treatment of infectious diseases. previous studies reported that the occurrence of drug-resistant pathogens (drps)-for instance, methicillin-resistant staphylococcus aureus (mrsa), pseudomonas aeruginosa and extended-spectrum β-lactamase (esbl)-producing enterobacteriaceae-were associated with inappropriate antibiotic treatment that resulted in adverse outcomes. in addition, unnecessary use of broad-spectrum antibiotics ... | 2017 | 28779516 |
| non-pseudomonal ecthyma gangrenosum caused by methicillin-resistant staphylococcus aureus (mrsa) in a chronic alcoholic patient. | we report for the first time a case of non-pseudomonal ecthyma gangrenosum (eg) caused by methicillin-resistant staphylococcus aureus in a chronic alcoholic without an associated immunocompromised state or disease. eg is an infection of the skin, commonly associated with pseudomonas aeruginosa bacteraemia, though other organisms are also known to be causally related. it usually occurs in patients who are terminally ill and the immunocompromised. in our case, chronic alcoholism with suppression o ... | 2017 | 28775089 |
| evaluation of the antibacterial power and biocompatibility of zinc oxide nanorods decorated graphene nanoplatelets: new perspectives for antibiodeteriorative approaches. | nanotechnologies are currently revolutionizing the world around us, improving the quality of our lives thanks to a multitude of applications in several areas including the environmental preservation, with the biodeterioration phenomenon representing one of the major concerns. | 2017 | 28764786 |
| screening bioactivity and bioactive constituents of nordic unifloral honeys. | the objective of this study was to screen the antibacterial and antioxidant activity of thirty nine honey samples from finland, sweden, norway and denmark. their physicochemical properties were analysed, antioxidant activity was evaluated by dpph assay and antibacterial activity against pseudomonas aeruginosa and staphylococcus aureus was assessed by microdilution assay. the honey samples obtained were buckwheat, caraway, clover, dandelion, fireweed, heather, lime tree, lingonberry, rape, raspbe ... | 2017 | 28763988 |
| development of an accumulation assay and evaluation of the effects of efflux pump inhibitors on the retention of chlorhexidine digluconate in pseudomonas aeruginosa and staphylococcus aureus. | chlorhexidine digluconate (chg) is used as a disinfectant. the emergence of pathogens resistant to the biocide raises health concern. information on specific efflux mechanisms utilised by bacteria to confer reduced susceptibility to the biocide, may be used to develop ways of preventing the efflux of the biocide from nosocomial pathogens resulting in higher disinfection activity. the aim of the study was to evaluate the role of atp-binding cassette transporters on the transport of chg in bacteri ... | 2017 | 28747232 |
| melipona mondury produces a geopropolis with antioxidant, antibacterial and antiproliferative activities. | geopropolis is a special type of propolis produced by stingless bees. several pharmacological properties have been described for different types of geopropolis, but there have been no previous studies of the geopropolis from melipona mondury. in this study, we investigated the antioxidant, antibacterial, and antiproliferative activities of m. mondury geopropolis, and determined its chemical profile. the antioxidant activity was determined using in vitro abts·+, ·dpph, and β-carotene/linoleic aci ... | 2017 | 28746550 |
| the detrimental impact of extracellular bacterial proteases on wound healing. | in addition to clinical signs of infection (e.g. inflammation, purulence and pain), a microbial count of ≥10(5) colony-forming units/g has historically been used to define wound infection. however, it is increasingly recognised that, rather than a high bioburden level alone being detrimental to wound healing, it is the virulence of the invading microorganism and the host's immune status that can affect clinical outcomes. bacteria, such as pseudomonas aeruginosa, staphylococcus aureus and staphyl ... | 2017 | 28745010 |
| topical sevoflurane for chronic venous ulcers infected by multi-drug-resistant organisms. | several anaesthetic drugs have demonstrated antibacterial properties in vitro. anaesthetics can primarily affect the cell wall of both susceptible and multi-resistant bacteria. they may also have a synergistic effect with conventional antibiotics through an unknown mechanism. we present three cases of a chronic venous ulcer infected by multi-resistant bacteria refractory to conventional systemic antibiotics, including pseudomonas aeruginosa and methicillin-resistant staphylococcus aureus (mrsa). ... | 2017 | 28736974 |
| antimicrobial resistance in the next 30 years, humankind, bugs and drugs: a visionary approach. | to describe the current standards of care and major recent advances with regard to antimicrobial resistance (amr) and to give a prospective overview for the next 30 years in this field. | 2017 | 28733718 |
| antimicrobial activity of disinfectants commonly used in the food industry in mexico. | disinfectants are widely used in food processing environments for microorganism control; their activity can vary according the microorganism and their used in the appropriated concentrations is vital. hence, the aim of this study was determined the effectiveness and minimum inhibitory concentration (mic) of 15 disinfectants commonly used in the food industry in mexico. | 2017 | 28732782 |
| novel role of surfactant protein a in bacterial sinusitis. | chronic rhinosinusitis (crs) is a common inflammatory disorder of the upper airway characterized by chronic inflammation and significant sinonasal remodeling. crs is comprised of 2 major subgroups, based on whether polyps are present or absent. in some cases, it is characterized by colonization with opportunistic pathogens such as pseudomonas aeruginosa (pa), staphylococcus aureus, and other bacteria. the innate immune system of the sinonasal epithelium is the first line of defense against inhal ... | 2017 | 28727907 |
| antimicrobial activity of selected polyphenols and capsaicinoids identified in pepper (capsicum annuum l.) and their possible mode of interaction. | antimicrobial activity of pepper polyphenols and capsaicinoids (coumarin, caffeic acid, narangin, kaempferol, rutin, quercetin, capsaicin, and dihydrocapsaicin) against 13 pathogen bacteria and three beneficial strains was studied using the disk diffusion and microdilution methods. in general, phenolic compounds had the most important activity with the highest inhibition zones obtained with caffeic acid (3.5-20.5 mm), quercetin (4.75-3.5 mm), and kaempferol (7-14 mm). in the determination of the ... | 2017 | 28721659 |
| pseudomonas aeruginosa alters staphylococcus aureus sensitivity to vancomycin in a biofilm model of cystic fibrosis infection. | the airways of cystic fibrosis (cf) patients have thick mucus, which fosters chronic, polymicrobial infections. pseudomonas aeruginosa and staphylococcus aureus are two of the most prevalent respiratory pathogens in cf patients. in this study, we tested whether p. aeruginosa influences the susceptibility of s. aureus to frontline antibiotics used to treat cf lung infections. using our in vitro coculture model, we observed that addition of p. aeruginosa supernatants to s. aureus biofilms grown ei ... | 2017 | 28720732 |
| frequency of common bacteria and their antibiotic sensitivity pattern in diabetics presenting with foot ulcer. | foot ulcers are one of the most important complications of diabetes mellitus and often lead to lower limb amputation. diabetic foot ulcers are susceptible to infection. the objective of this study was to determine the frequency of common bacteria infecting these ulcers and their antibiotic sensitivity pattern. | 2017 | 28712228 |
| bacterial profile and antibiogram of otitis media among children in yemen. | otitis media is a worldwide disease and is higher in developing countries, particularly among the low socioeconomic levels of the society. the aim of the study is to identify the bacterial etiologic agents of otitis media (om) and their antibiotics sensitivity patterns among children in specialized sam paediatric centre (sspc) and al-mamoon diagnostic medical centre (amdc), in sana'a city. | 2017 | 28712217 |
| retrospective observational study of french patients with cystic fibrosis and a gly551asp-cftr mutation after 1 and 2years of treatment with ivacaftor in a real-world setting. | ivacaftor has been shown to improve lung function and body weight in patients with cf and a gating mutation. real-world evaluation is warranted to examine its safety and effectiveness over the long term. | 2017 | 28711222 |
| intrawound application of vancomycin changes the responsible germ in elective spine surgery without significant effect on the rate of infection: a randomized prospective study. | surgical site infection (ssi) is a costly complication associated with spine surgery. the impact of intrawound vancomycin has not been strongly postulated to decrease the risk of surgical site infection. we designed study to determine whether intrawound vancomycin application reduces the risk of ssi in patients after spine surgery. | 2017 | 28699136 |
| estimating direct cost of cystic fibrosis care using irish registry healthcare resource utilisation data, 2008-2012. | understanding the determinants of cost of cystic fibrosis (cf) care and health outcomes may be useful for financial planning for the delivery of cf services. registries contain information otherwise unavailable to healthcare activity/cost monitoring systems. we estimated the direct medical cost of cf care using registry data and examined how cost was affected by patient characteristics and cf gene (cf transmembrane conductance regulator [cftr]) mutation. | 2017 | 28699086 |
| community composition determines activity of antibiotics against multispecies biofilms. | in young cystic fibrosis (cf) patients, staphylococcus aureus is typically the most prevalent organism, while in adults, pseudomonas aeruginosa is the major pathogen. more recently, it was observed that also streptococcus anginosus plays an important role in exacerbations of respiratory symptoms. these species are often coisolated from cf lungs, yet little is known about whether antibiotic killing of one species is influenced by the presence of others. in the present study, we compared the activ ... | 2017 | 28696232 |
| bioactivity of ceftazidime and fluconazole included in polymethyl methacrylate bone cement for use in arthroplasty. | the microorganisms that most frequently cause prosthetic joint infection are methicillin-resistant staphylococcus aureus and gram-negative aerobic bacillus. studies have documented the efficacy of mixing antibiotics with polymethyl methacrylate, but that of antifungal drugs has not received much attention. the objective of this in vitro study was to characterize the elution profile and bioactivity of ceftazidime and fluconazole when incorporated into bone cement in proportions intended for proph ... | 2017 | 28690040 |
| bactericidal activity of self-assembled palmitic and stearic fatty acid crystals on highly ordered pyrolytic graphite. | the wings of insects such as cicadas and dragonflies have been found to possess nanostructure arrays that are assembled from fatty acids. these arrays can physically interact with the bacterial cell membranes, leading to the death of the cell. such mechanobactericidal surfaces are of significant interest, as they can kill bacteria without the need for antibacterial chemicals. here, we report on the bactericidal effect of two of the main lipid components of the insect wing epicuticle, palmitic (c ... | 2017 | 28688988 |
| effectiveness of topical application of ostrich oil on the healing of staphylococcus aureus- and pseudomonas aeruginosa-infected wounds. | management of infected wounds is one of the major challenges that surgeons and nurses face. several antimicrobial agents have been used, but the toxicity, drug resistance, and their effect on the healing process remain a matter of concern. the present study was designed to analyze the accelerative impact of topical application of ostrich oil on infected wounds in a mouse model. | 2017 | 28682114 |
| antimicrobial ceragenins inhibit biofilms and affect mammalian cell viability and migration in vitro. | the healing of burn wounds is often hampered by bacterial infection and the formation of biofilms. antimicrobial peptides (amps) are effective in promoting wound healing, but are susceptible to degradation. we have tested the ability of ceragenins (csas), mimics of antimicrobial peptides, to mitigate preformed biofilms and stimulate wound healing in vitro. potent csas (mics < 10 μg·ml(-1)) were tested against biofilms formed from a mixture of pseudomonas aeruginosa and staphylococcus aureus grow ... | 2017 | 28680809 |
| activity of innate antimicrobial peptides and ivacaftor against clinical cystic fibrosis respiratory pathogens. | there is a clear need for new antimicrobials to improve current treatment of chronic lung infection in people with cystic fibrosis (cf). this study determined the activities of antimicrobial peptides (amps) and ivacaftor, a novel cf transmembrane conductance regulator potentiator, for cf treatment. antimicrobial activities of amps [ll37, human β-defensins (hβd) 1-4 and slpi] and ivacaftor against clinical respiratory isolates (pseudomonas aeruginosa, staphylococcus aureus, streptococcus spp., ac ... | 2017 | 28666755 |
| properties of induced antimicrobial activity in musca domestica larvae. | insects produce antimicrobial molecules that contribute to their innate immune responses to eliminate invading microorganisms. to explore the potential utility of these antimicrobial molecules, we focused on larvae of the house fly musca domestica, which is an efficient processor of organic waste and a good resource of protein and oil for animal feeding. the induction of hemagglutinating activity, which is usually accompanied by activation of innate immune responses in fly larvae, was observed i ... | 2017 | 28652511 |
| komodo dragon-inspired synthetic peptide drgn-1 promotes wound-healing of a mixed-biofilm infected wound. | cationic antimicrobial peptides are multifunctional molecules that have a high potential as therapeutic agents. we have identified a histone h1-derived peptide from the komodo dragon (varanus komodoensis), called vk25. using this peptide as inspiration, we designed a synthetic peptide called drgn-1. we evaluated the antimicrobial and anti-biofilm activity of both peptides against pseudomonas aeruginosa and staphylococcus aureus. drgn-1, more than vk25, exhibited potent antimicrobial and anti-bio ... | 2017 | 28649410 |
| ecological networking of cystic fibrosis lung infections. | in the context of a polymicrobial infection, treating a specific pathogen poses challenges because of unknown consequences on other members of the community. the presence of ecological interactions between microbes can change their physiology and response to treatment. for example, in the cystic fibrosis lung polymicrobial infection, antimicrobial susceptibility testing on clinical isolates is often not predictive of antibiotic efficacy. novel approaches are needed to identify the interrelations ... | 2016 | 28649398 |
| variation in empiric coverage versus detection of methicillin-resistant staphylococcus aureus and pseudomonas aeruginosa in hospitalizations for community-onset pneumonia across 128 us veterans affairs medical centers. | objective to examine variation in antibiotic coverage and detection of resistant pathogens in community-onset pneumonia. design cross-sectional study. setting a total of 128 hospitals in the veterans affairs health system. participants hospitalizations with a principal diagnosis of pneumonia from 2009 through 2010. methods we examined proportions of hospitalizations with empiric antibiotic coverage for methicillin-resistant staphylococcus aureus (mrsa) and pseudomonas aeruginosa (paer) and with ... | 2017 | 28633678 |
| albumin inhibits pseudomonas aeruginosa quorum sensing and alters polymicrobial interactions. | polymicrobial interactions are complex and can influence the course of an infection, as is the case when two or more species exhibit a synergism that produces a disease state not seen with any of the individual species alone. cell-to-cell signaling is key to many of these interactions, but little is understood about how the host environment influences polymicrobial interactions or signaling between bacteria. chronic wounds are typically polymicrobial, with staphylococcus aureus and pseudomonas a ... | 2017 | 28630071 |
| antibacterial, anticancer and neuroprotective activities of rare actinobacteria from mangrove forest soils. | mangrove is a complex ecosystem that contains diverse microbial communities, including rare actinobacteria with great potential to produce bioactive compounds. to date, bioactive compounds extracted from mangrove rare actinobacteria have demonstrated diverse biological activities. the discovery of three novel rare actinobacteria by polyphasic approach, namely microbacterium mangrovi musc 115(t), sinomonas humi musc 117(t) and monashia flava musc 78(t) from mangrove soils at tanjung lumpur, penin ... | 2017 | 28611495 |
| airway glucose homeostasis: a new target in the prevention and treatment of pulmonary infection. | in health, the glucose concentration of airway surface liquid (asl) is 0.4 mm, about 12 times lower than the blood glucose concentration. airway glucose homeostasis comprises a set of processes that actively maintain low asl glucose concentration against the transepithelial gradient. tight junctions between airway epithelial cells restrict paracellular glucose movement. epithelial cellular glucose transport and metabolism removes glucose from asl. low asl glucose concentrations make an important ... | 2017 | 28610911 |
| mechanisms of pyocyanin toxicity and genetic determinants of resistance in staphylococcus aureus. | pseudomonas aeruginosa and staphylococcus aureus are commonly isolated from polymicrobial infections, such as wound infections and chronic respiratory infections of persons with cystic fibrosis. despite their co-isolation, p. aeruginosa produces substances toxic to s. aureus, including pyocyanin, a blue pigmented molecule that functions in p. aeruginosa virulence. pyocyanin inhibits s. aureus respiration, forcing it to derive energy from fermentation and adopt a small colony variant (scv) phenot ... | 2017 | 28607159 |
| alcohol fixation of bacteria to surgical instruments increases cleaning difficulty and may contribute to sterilization inefficacy. | alcohol is frequently inappropriately used on surgical instruments to reduce bacterial contamination, but fixes protein to stainless steel. here we compare the effect of air drying, prolonged soaking in water, and alcohol treatment on cleaning difficulty of contaminated forceps. | 2017 | 28602275 |
| taking the silver bullet colloidal silver particles for the topical treatment of biofilm-related infections. | biofilms are aggregates of bacteria residing in a self-assembled matrix, which protects these sessile cells against external stress, including antibiotic therapies. in light of emerging multidrug-resistant bacteria, alternative strategies to antibiotics are emerging. the present study evaluated the activity of colloidal silver nanoparticles (agnps) of different shapes against biofilms formed by staphylococcus aureus (sa), methicillin-resistant sa (mrsa), and pseudomonas aeruginosa (pa). colloida ... | 2017 | 28598149 |
| contribution of progranulin to protective lung immunity during bacterial pneumonia. | progranulin (pgrn) is an important immunomodulatory factor in a variety of inflammatory diseases. however, its role in pulmonary immunity against bacterial infection remains unknown. | 2017 | 28595330 |
| adsorption and photocatalysis efficiency of magnetite quantum dots anchored tin dioxide nanofibers for removal of mutagenic compound: toxicity evaluation and antibacterial activity. | the magnetite fe3o4 quantum dots anchored sno2 nanofibers (fe3o4 qds/sno2 nfs) have been synthesized using the facile one step hydrothermal method. the characteristic structure of synthesized fe3o4 qds/sno2 nfs was analyzed using x-ray diffraction, transmission electron microscopy, scanning electron microscopy, uv-vis diffuse reflectance, photoluminescence spectroscopy, and n2 adsorption-desorption instrumental techniques. the crystallites size of fe3o4qds/sno2 nfs was 7.0nm. the average diamete ... | 2017 | 28595075 |
| quantitative analysis of povidone-iodine thin films by x-ray photoelectron spectroscopy and their physicochemical properties. | in this study, povidone-iodine (pvp-i) has been formulated as a topical spray to produce a thin film for the controlled release of i2. by means of experimental design, 27 formulations containing glycerol, ethanol, peg 400, copovidone and hfa 134a as a propellant were prepared. the ph values of all formulations were in the range of 6-7. the viscosity was within the range of 11.9-85.9 mpa s. the surface tensions were 20.3 to 24.6 mn m-1 and the contact angles were between 19.3 and 38.7°. the assay ... | 2017 | 28590912 |
| a comparison of the efficacy of mechanical, chemical, and microwave radiation methods in disinfecting complete dentures. | poor denture hygiene can be a potential source of pathogens. the aim of this study was to compare the efficacy of microwave radiation with that of chemical and mechanical techniques in disinfecting complete dentures contaminated with staphylococcus aureus and pseudomonas aeruginosa. | 2017 | 28584537 |
| a multi-defense strategy: enhancing bactericidal activity of a medical grade polymer with a nitric oxide donor and surface-immobilized quaternary ammonium compound. | although the use of biomedical devices in hospital-based care is inevitable, unfortunately, it is also one of the leading causes of the nosocomial infections, and thus demands development of novel antimicrobial materials for medical device fabrication. in the current study, a multi-defense mechanism against gram-positive and gram-negative bacteria is demonstrated by combining a nitric oxide (no) releasing agent with a quaternary ammonium antimicrobial that can be covalently grafted to medical de ... | 2017 | 28579540 |
| new strategies targeting virulence factors of staphylococcus aureus and pseudomonas aeruginosa. | | 2017 | 28578557 |
| attributable mortality of healthcare-associated infections due to multidrug-resistant gram-negative bacteria and methicillin-resistant staphylococcus aureus. | objective the purpose of this study was to quantify the effect of multidrug-resistant (mdr) gram-negative bacteria and methicillin-resistant staphylococcus aureus (mrsa) healthcare-associated infections (hais) on mortality following infection, regardless of patient location. methods we conducted a retrospective cohort study of patients with an inpatient admission in the us department of veterans affairs (va) system between october 1, 2007, and november 30, 2010. we constructed multivariate log-b ... | 2017 | 28566096 |
| hybrid nanoparticles for the topical delivery of norfloxacin for the effective treatment of bacterial infection produced after burn. | the present study was designed to investigate the solubility and penetrability of norfloxacin after the topical application of developed lipid-polymer hybrid nanoparticle (lpn) formulation. the core shell of the lpns formulation was composed of poly (lactic-co-glycolic acid) that is highly lipophilic in nature, thus control the release of drug. the developed formulations were characterised for size, shape (transmission electron microscopy [tem], scanning electron microscopy [sem], and atomic for ... | 2017 | 28562141 |
| co-infecting microorganisms dramatically alter pathogen gene essentiality during polymicrobial infection. | identifying genes required by pathogens during infection is critical for antimicrobial development. here, we use a monte carlo simulation-based method to analyse high-throughput transposon sequencing data to determine the role of infection site and co-infecting microorganisms on the in vivo 'essential' genome of staphylococcus aureus. we discovered that co-infection of murine surgical wounds with pseudomonas aeruginosa results in conversion of ∼25% of the in vivo s. aureus mono-culture essential ... | 2017 | 28555625 |
| co-evolution with staphylococcus aureus leads to lipopolysaccharide alterations in pseudomonas aeruginosa. | detrimental and beneficial interactions between co-colonizing bacteria may influence the course of infections. in cystic fibrosis (cf) airways, staphylococcus aureus prevails in childhood, whereas pseudomonas aeruginosa progressively predominates thereafter. while a range of interactions has been identified, it is unclear if these represent specific adaptations or correlated responses to other aspects of the environment. here, we investigate how p. aeruginosa adapts to s. aureus by evolving p. a ... | 2017 | 28548661 |
| effect of tamarindus indica l. and manihot esculenta extracts on antibiotic-resistant bacteria. | the chemical composition of plants used in traditional medicine exhibits biologically active compounds, such as tannins, flavonoids, and alkaloids and becomes a promising approach to treat microbial infections, mainly with drug-resistant bacteria. | 2017 | 28539745 |
| evolution of bacterial "frenemies". | chronic polymicrobial infections are associated with increased virulence compared to monospecies infections. however, our understanding of microbial dynamics during polymicrobial infection is limited. a recent study by limoli and colleagues (d. h. limoli, g. b. whitfield, t. kitao, m. l. ivey, m. r. davis, jr., et al., mbio 8:e00186-17, 2017, https://doi.org/10.1128/mbio.00186-17) provides insight into a mechanism that may contribute to the coexistence of pseudomonas aeruginosa and staphylococcu ... | 2017 | 28536291 |
| influence of nanoscale topology on bactericidal efficiency of black silicon surfaces. | the nanostructuring of materials to create bactericidal and antibiofouling surfaces presents an exciting alternative to common methods of preventing bacterial adhesion. the fabrication of synthetic bactericidal surfaces has been inspired by the anti-wetting and anti-biofouling properties of insect wings, and other topologies found in nature. black silicon is one such synthetic surfaces which has established bactericidal properties. in this study we show that time-dependent plasma etching of sili ... | 2017 | 28534474 |
| an unsaturated quinolone n-oxide of pseudomonas aeruginosa modulates growth and virulence of staphylococcus aureus. | the pathogen pseudomonas aeruginosa produces over 50 different quinolones, 16 of which belong to the class of 2-alkyl-4-quinolone n-oxides (aqnos) with various chain lengths and degrees of saturation. we present the first synthesis of a previously proposed unsaturated compound that is confirmed to be present in culture extracts of p. aeruginosa, and its structure is shown to be trans-δ(1) -2-(non-1-enyl)-4-quinolone n-oxide. this compound is the most active agent against s. aureus, including mr ... | 2017 | 28523838 |
| in vitro evaluation of betafoam, a new polyurethane foam dressing. | a new polyurethane foam dressing impregnated with 3% povidone-iodine (betafoam; genewell, seoul, korea) was recently developed based on the hypothesis that its physical properties, including improved moisture-retention capacity and antimicrobial activity, are at least as good as those achieved with the current foam dressings that contain silver, but also associated with reduced cost and cytotoxicity to host cells. the purpose of this in vitro study was to evaluate the efficacy of betafoam by com ... | 2017 | 28520604 |
| microbiological testing of devices used in maintaining peripheral venous catheters. | to evaluate the use of peripheral venous catheters based on microbiological analysis of devices (dressing and three-way stopcocks) and thus contribute to the prevention and infection control. | 2017 | 28513768 |
| inhaled antibiotic therapy in chronic respiratory diseases. | the management of patients with chronic respiratory diseases affected by difficult to treat infections has become a challenge in clinical practice. conditions such as cystic fibrosis (cf) and non-cf bronchiectasis require extensive treatment strategies to deal with multidrug resistant pathogens that include pseudomonas aeruginosa, methicillin-resistant staphylococcus aureus, burkholderia species and non-tuberculous mycobacteria (ntm). these challenges prompted scientists to deliver antimicrobial ... | 2017 | 28509852 |
| preparation and characterization of pistacia khinjuk gum nanoparticles using response surface method: evaluation of its anti-bacterial performance and cytotoxicity. | purpose: this study aims to prepare a novel, natural nanoparticle (np) as a drug carrier, which also has inherent therapeutic effects. methods: pistacia khinjuk gum nps were prepared and response surface methodology (rsm) was used for statistical analysis of data and optimizing the size of nps. results: nps were in the range of 75.85-241.3 nm. the optimization study was carried out, and an optimized size (70.86nm) was obtained using dmso as a solvent. the volume of the organic phase was 111.25µl ... | 2017 | 28507950 |
| a quantitative mechanistic pk/pd model directly connects btk target engagement and in vivo efficacy. | correlating target engagement with in vivo drug activity remains a central challenge in efforts to improve the efficiency of drug discovery. previously we described a mechanistic pharmacokinetic-pharmacodynamic (pk/pd) model that used drug-target binding kinetics to successfully predict the in vivo efficacy of antibacterial compounds in models of pseudomonas aeruginosa and staphylococcus aureus infection. in the present work we extend this model to quantitatively correlate the engagement of brut ... | 2017 | 28507715 |
| ciprofloxacin-loaded lipid-core nanocapsules as mucus penetrating drug delivery system intended for the treatment of bacterial infections in cystic fibrosis. | treatment of bacterial airway infections is essential for cystic fibrosis therapy. however, effectiveness of antibacterial treatment is limited as bacteria inside the mucus are protected from antibiotics and immune response. to overcome this biological barrier, ciprofloxacin was loaded into lipid-core nanocapsules (lnc) for high mucus permeability, sustained release and antibacterial activity. ciprofloxacin-loaded lnc with a mean size of 180nm showed a by 50% increased drug permeation through mu ... | 2017 | 28499793 |
| ecthyma gangrenosum secondary to methicillin-sensitive staphylococcus aureus. | ecthyma gangrenosum (eg) is a well-described skin manifestation of pseudomonas aeruginosa septicemia in immunocompromised patients. however, it can be seen in association with other bacteria, viruses, and fungi. we report a case of a 54-year-old african american female with metastatic gastric adenocarcinoma and recent chemotherapy and neutropenia who developed eg-like lesions due to methicillin-susceptible staphylococcus aureus. we also review the literature to evaluate all reported cases of s a ... | 2016 | 28492017 |
| prevalence of healthcare-associated infections and antimicrobial use among adult inpatients in singapore acute-care hospitals: results from the first national point prevalence survey. | we conducted a national point prevalence survey (pps) to determine the prevalence of healthcare-associated infections (hais) and antimicrobial use (amu) in singapore acute-care hospitals. | 2017 | 28475790 |