| [to the state of the fetoplacental complex in women with the threat of abortion]. | the goal is a comprehensive study of the morphofunctional state of the mother-placenta-fetus system in placental insufficiency and infection. 250 pregnant and puerperas for the period 2008-2014 were examined. detection of bacterial flora was carried out in 35 pregnant women aged 20.4±0.8 years with the threat of abortion from an early gestation period and a prolonged persistent infection of the genitals, bacterial vaginosis. methods are applied: culture, ion chromatography, gas-liquid chromatogr ... | 2017 | 28820412 |
| marinocyanins, cytotoxic bromo-phenazinone meroterpenoids from a marine bacterium from the streptomycete clade mar4. | six cytotoxic and antimicrobial metabolites of a new bromo-phenazinone class, the marinocyanins a-f (1-6), were isolated together with the known bacterial metabolites 2-bromo-1-hydroxyphenazine (7), lavanducyanin (8, ws-9659a) and its chlorinated analog ws-9659b (9). these metabolites were purified by bioassay-guided fractionation of the extracts of our mar4 marine actinomycete strains cns-284 and cny-960. the structures of the new compounds were determined by detailed spectroscopic methods and ... | 2017 | 28814819 |
| bioactive potential of 3d-printed oleo-gum-resin disks: b. papyrifera, c. myrrha, and s. benzoin loading nanooxides-tio2, p25, cu2o, and moo3. | this experimental study investigates the bioactive potential of filaments produced via hot melt extrusion (hme) and intended for fused deposition modeling (fdm) 3d printing purposes. the oleo-gum-resins from benzoin, myrrha, and olibanum in pure state and also charged with 10% of metal oxide nanoparticles, tio2, p25, cu2o, and moo3, were characterized by ultraviolet-visible (uv-vis) and fourier transform infrared (ftir) spectroscopy, energy-dispersive x-ray microanalysis (edxma), scanning electr ... | 2017 | 28811751 |
| bioactive mesoporous silica nanostructures with anti-microbial and anti-biofilm properties. | the increasing rate of antibiotic resistant bacteria associated with nosocomial infections in severely ill patients has urged the need for new antibacterial therapies. nanostructured materials represent emerging innovative approaches to controlled delivery of different antimicrobial drugs. delivery systems encapsulating natural compounds with antibacterial effects, such as essential oils have shown a great potential. herein we report the development of sio2 mesoporous nanosystems loaded with euc ... | 2017 | 28797969 |
| cold atmospheric pressure plasmas exhibit antimicrobial properties against critical bacteria and yeast species. | cold atmospheric pressure plasmas (capps) have been used to sterilise implant materials and other thermally unstable medical products and to modify chemical surfaces. this study investigates the antimicrobial effect of the gas and input power used to generate capps on microorganisms causing skin infections, such as staphylococcus aureus, pseudomonas aeruginosa, candida albicans and malassezia pachydermatis. | 2017 | 28795887 |
| nanoscale silver depositions inhibit microbial colonization and improve biocompatibility of titanium abutments. | although titanium dental implants are biocompatible, exhibit excellent corrosion resistance and high mechanical resistance, the material fails in providing resistance to infection because it exhibits poor antimicrobial activity. to address these issues, we deposited silver onto titanium abutments (grade 5 titanium discs) using direct current (dc) sputtering and assessed the antimicrobial activity and biocompatibility of the modified implant material. atomic absorption spectrometry and x-ray phot ... | 2017 | 28783506 |
| thermo-and ph-sensitive hydrogel membranes composed of poly(n-isopropylacrylamide)-hyaluronan for biomedical applications: influence of hyaluronan incorporation on the membrane properties. | interpenetrating hydrogel membranes consisting of ph-sensitive hyaluronan (ha) and thermo-sensitive poly(n-isopropylacrylamide) (pnipaam) were synthesized using redox polymerization, followed by n,n-methylenebisacrylamide (bis) and epichlorohydrin (epi) were added as chemical crosslinkers. the interaction between membrane compositions has been characterized by ftir spectroscopy and discussed intensively. the result indicates that ha incorporation in membranes increase the gel fraction, swelling ... | 2017 | 28780413 |
| thymus vulgaris l. and thymol assist murine macrophages (raw 264.7) in the control of in vitro infections by staphylococcus aureus, pseudomonas aeruginosa, and candida albicans. | microorganisms are capable to combat defense cells by means of strategies that contribute to their stabilization and proliferation in invaded tissues. frequently antimicrobial-resistant strains appear; therefore, alternative methods to control them must be investigated, for example, the use of plant products. the capacity of the thyme extract (thymus vulgaris l.) and phytocompound thymol in the control of in vitro infections by staphylococcus aureus, pseudomonas aeruginosa, and candida albicans ... | 2017 | 28752199 |
| colorimetric sensing of toxic metal and antibacterial studies by using bioextract synthesized silver nanoparticles. | here, we report the simple and cost effective colorimetric technique for the determination of toxic metals (hg(2+)) in aqueous sample by using bioextract silver nanoparticles (agnps). the indigenous agnps were synthesised by green and ecologically friendly style using extract of fig (ficus carica) leaf. the synthesized agnps were confirmed by uv-vis spectroscopy, ft-ir spectroscopy, and scanning electron microscopy methods. the synthesis of agnps was observed by its colour changing from light ye ... | 2017 | 28748516 |
| essential oils and hydrophilic extracts from the leaves and flowers of succisa pratensis moench. and their biological activity. | this study was undertaken to evaluate the antioxidant activity of methanol and water extracts from succisa pratensis moench (dipsacaceae) leaves and flowers as well as the chemical composition of the essential oils found in them and the antimicrobial activity of the oils and extracts thereof. | 2017 | 28744918 |
| antimicrobial, modulatory and chemical analysis of the oil of croton limae. | croton sp. are plants with a well-reported antimicrobial activity. croton limae a.p. gomes, m.f. sales p.e. berry (euphorbiaceae), known as 'marmeleiro-prateado', is commonly used to manage abdominal pain in brazil. | 2017 | 28738715 |
| slippery liquid-infused porous surfaces that prevent microbial surface fouling and kill non-adherent pathogens in surrounding media: a controlled release approach. | many types of slippery liquid-infused porous surfaces (or 'slips') can resist adhesion and colonization by microorganisms. these 'slippery' materials thus offer new approaches to prevent fouling on a range of commercial and industrial surfaces, including biomedical devices. however, while slips can prevent fouling on surfaces to which they are applied, they can currently do little to prevent the proliferation of non-adherent (planktonic) organisms, stop them from colonizing other surfaces, or pr ... | 2016 | 28713229 |
| role of biofilm in cerebrospinal fluid shunt infections: a study at tertiary neurocare center from south india. | biofilms are the source of persistent infections of many pathogenic microbes. they are responsible for nosocomial infection and also associated with many surgical conditions including indwelling medical devices such as ventriculoperitoneal shunt. a significant problem encountered in shunt procedures is obstruction followed by infection, with infection rate ranging from 2% to 27%, often with poor outcome. | 2017 | 28694609 |
| thymus vulgaris l. extract has antimicrobial and anti-inflammatory effects in the absence of cytotoxicity and genotoxicity. | this study evaluated the biological effects of the t. vulgaris l. extract., such as antimicrobial activity on planktonic cultures and mono- and polymicrobial biofilms, cytotoxicity, anti-inflammatory activity and genotoxicity. | 2017 | 28683409 |
| nbiochip, a lab-on-a-chip platform of mono- and polymicrobial biofilms for high-throughput downstream applications. | current in vitro techniques for the culture of microorganisms, and particularly of delicate microbial biofilms, are still mostly limited to low-density plates and manual labor and are not amenable to automation and true high-throughput (ht) applications. we have developed a novel fully automated platform for the formation of mono- and polymicrobial biofilms of staphylococcus aureus, pseudomonas aeruginosa, and candida albicans at the nanoscale level. the nbiochip is robotically printed, robustly ... | 2017 | 28680970 |
| effect of treatment with caspofungin on the diagnosis of fungal infections by gamma scintigraphy. | the aim of this work is to assess the influence of treatment with unlabeled-caspofungin, on the quality of diagnostic scintigraphic images of induced lesions in nude mice undergoing both bacterial and fungal infections and to determine the level of specificity of 99mtc-tricarbonyl-caspofungin to discriminate between fungal or bacterial infections. in vitro studies on the behaviour of the 99mtc-tricarbonyl-caspofungin complex binding percentage at different yeast concentrations of candida albican ... | 2017 | 28675994 |
| composition and antimicrobial activity of the essential oil from the branches of jacaranda cuspidifolia mart. growing in sichuan, china. | this study represents the first report on the chemical composition and antimicrobial activity of the essential oil from the branches of jacaranda cuspidifolia mart. thirty-three compounds were identified by gas chromatography-mass spectrometry (gc-ms) and the major constituents of the essential oil were palmitic acid (31.36%), (z) - 9,17-octadecadienal (12.06%), ethyl palmitate (3.81%), perhydrofarnesyl acetone (2.07%), γ-maaliene (1.88%), and cedro (1.42%) and 9,12-octadecadienoic acid ethyl es ... | 2017 | 28670931 |
| comparison of dna extraction methods used to detect bacterial and yeast dna from spiked whole blood by real-time pcr. | sepsis is the leading cause of death in intensive care units (icus) worldwide and its diagnosis remains a challenge. blood culturing is the gold standard technique for blood stream infection (bsi) identification. molecular tests to detect pathogens in whole blood enable early use of antimicrobials and affect clinical outcomes. here, using real-time pcr, we evaluated dna extraction using seven manual and three automated commercially available systems with whole blood samples artificially contamin ... | 2017 | 28669799 |
| bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra. | cyclotides are a family of plant peptides characterized by a cystine knot embedded in a macrocyclic backbone. they bind to and disrupt phospholipid membranes, which explain their lytic activity on cells. in this study, we expose the full antibacterial potency of cyclotides by avoiding its inhibition by rich growth media assay conditions. for that purpose a two-step microdilution assay protocol was developed, using non-growing conditions during initial peptide incubation. a diverse set of cycloti ... | 2017 | 28669767 |
| soluble factors from biofilm of candida albicans and staphylococcus aureus promote cell death and inflammatory response. | the objective of this study was to better understand the effects of soluble factors from biofilm of single- and mixed-species candida albicans (c. albicans) and methicillin-sensitive staphylococcus aureus (mssa) cultures after 36 h in culture on keratinocytes (nok-si and hacat) and macrophages (j774a.1). soluble factors from biofilms of c. albicans and mssa were collected and incubated with keratinocytes and macrophages, which were subsequently evaluated by cell viability assays (mtt). lactate d ... | 2017 | 28666415 |
| isolation and characterization of sesquiterpenoids from cassia buds and their antimicrobial activities. | cassia buds, the immature fruits of cinnamomum cassia (lauraceae), are widely consumed as a food spice, dietary supplements, flavoring agents, and preservatives. in this study, cassia buds were phytochemically investigated for the first time, leading to the isolation of 2 new sesquiterpenoids (1 and 2) and 10 known sesquiterpenoids (3-12). their structures were determined by spectrometric and spectroscopic analyses, including nuclear magnetic resonance, high-resolution electrospray ionization ma ... | 2017 | 28665598 |
| thermoplastic polyurethane-based intravaginal rings for prophylaxis and treatment of (recurrent) bacterial vaginosis. | the aim of the present study was to develop thermoplastic polyurethane (tpu)-based intravaginal rings (ivrs) for prophylaxis and treatment of bacterial vaginosis via hot melt extrusion/injection molding. therefore, different tpu grades were processed in combination with lactic acid or metronidazole, targeting a sustained lactic acid release over a 28day-period and sustained metronidazole release over 4-7days. hot melt extrusion of lactic acid/tpu combinations required a lower extrusion temperatu ... | 2017 | 28663088 |
| chemical composition and antimicrobial activity of the essential oil of mentha mozaffarianii jamzad growing wild and cultivated in iran. | the aerial parts of wild and cultivated mentha mozaffarianii jamzad were collected at full flowering stage from two provinces (hormozgan and fars) of iran. the essential oils were extracted by a clevenger approach and analysed using gc and gc-ms. the main components in wild plants were piperitenone (33.85%), piperitone (21.18%), linalool (6.89%), pulegone (5.93%), 1, 8.cineole (5.49%), piperitenone oxide (5.17%) and menthone (4.69%) and in cultivated plants, cis-piperitone epoxide (28.89%), lina ... | 2017 | 28658991 |
| microbiological purity assessment of cosmetics used by one and several persons and cosmetics after their expiry date | microbiological purity of cosmetics provides safety of users during their use, prevents physicochemical changes of a preparation, infections and diseases of the skin. | 2017 | 28646837 |
| the antimicrobial spectrum of xeroform(®). | xeroform(®) is a petrolatum-based fine mesh gauze containing 3% bismuth tribromophenate. bismuth, similar to other metals, has antimicrobial properties. xeroform(®) has been used for decades in burn and plastic surgery as a donor site dressing and as a covering for wounds or partial thickness burns. despite this, the antimicrobial spectrum of xeroform(®) remains largely unknown. we examined the in-vitro efficacy of xeroform(®) against common burn pathogens using zone-of-inhibition methodology in ... | 2017 | 28641915 |
| pathogen-specific mortality in very low birth weight infants with primary bloodstream infection. | mortality in very low birth weight infants following microbiology confirmed primary bloodstream infections varies with the type of causative pathogen. given evidence from other studies that infections with gram negative bacteria and fungi cause a higher case fatality risk. we tried to confirm this in a nation-wide multi-center trial. | 2017 | 28640920 |
| whole blood profiling of bacillus calmette-guérin-induced trained innate immunity in infants identifies epidermal growth factor, il-6, platelet-derived growth factor-ab/bb, and natural killer cell activation. | vaccination of infants with bacillus calmette-guérin (bcg) activates both the innate and adaptive arms of the immune response. the antimycobacterial effects of these responses most likely account for the ability of bcg to protect against childhood forms of tuberculosis (tb). there is also evidence for a heterologous protective effect of bcg vaccination against tb-unrelated mortality in low birth weight infants. a possible mechanism of action of this effect, the induction of trained innate immuni ... | 2017 | 28634479 |
| variation of alkaloid contents and antimicrobial activities of papaver rhoeas l. growing in turkey and northern cyprus. | papaver rhoeas l. (papaveraceae) corn poppy, widely distributed in turkey, is used to make a cough syrup for children, as a tea for disturbed sleep, for pain relief and as a sedative in folk medicine. | 2017 | 28633584 |
| in vitro evaluation of antimicrobial activity of alimentary canal extracts from the red palm weevil, rhynchophorus ferrugineus olivier larvae. | the invasive red palm weevil, rhynchophorus ferrugineus olivier (coleoptera: curculionidae), is considered one of the world's most devastating insect pests to palm trees. it was observed that larvae of this pest are able to inhibit microbial growth on the rearing media when they start feeding and this observation has led us to study the effect of red palm weevils on various microbial species. the antimicrobial effect of extracts from different parts of the alimentary canal on gram positive bacte ... | 2017 | 28612029 |
| effect of supercritical carbon dioxide extraction parameters on the biological activities and metabolites present in extracts from arthrospira platensis. | arthrospira platensis was used to obtain functional extracts through supercritical carbon dioxide extraction (sfe-co₂). pressure (p), temperature (t), co-solvent (cx), static extraction (sx), dispersant (di) and dynamic extraction (dx) were evaluated as process parameters through a plackett-burman design. the maximum extract yield obtained was 7.48 ± 0.15% w/w. the maximum contents of bioactive metabolites in extracts were 0.69 ± 0.09 µg/g of riboflavin, 5.49 ± 0.10 µg/g of α-tocopherol, 524.46 ... | 2017 | 28604646 |
| in vitro antimicrobial potential of extracts and phytoconstituents from gymnema sylvestre r.br. leaves and their biosafety evaluation. | the in vitro antimicrobial screening of gymnema sylvestre leaves against 13 test pathogens established its broad spectrum activity with average inhibition zone ranging from 14 to 23 mm. the antimicrobial activity of the classically- optimized aqueous extract was enhanced up to 1.45 folds, when subjected to statistical optimization using response surface methodology (rsm) and was thermostable. ethyl acetate was found to be the best organic extractant with klebsiella pneumoniae 1 (31.5 mm) and sta ... | 2017 | 28587443 |
| testing antifungal vaccines in an animal model of invasive candidiasis and in human mucosal candidiasis. | the following article will concentrate on the ndv-3 anti-candida and staphylococcus vaccine. the vaccine is composed of the n-terminal portion of the candida albicans agglutinin-like sequence 3 protein (als3p) and aluminum hydroxide as adjuvant. the vaccine conferred protection to mice against experimental vaginal, oral, and intravenous challenge with c. albicans. due to the sequence and structural homology of the als3p with staphylococcus aureus surface proteins, the vaccine also protected agai ... | 2017 | 28585001 |
| totally implantable venous access devices in children with medical complexity: preliminary data from a tertiary care hospital. | children with special health-care needs are an emerging and consistent population. in a subset of children with medical complexity (cmc) a continuous access to the central vascular system is advisable to eliminate unnecessary pain and stress and to improve home management and palliative care. | 2017 | 28574141 |
| cytotoxic, anti-cancer, and anti-microbial effects of different extracts obtained from artemisia rupestris. | artemisia rupestris is a part of traditional kazakh folk medicine. extracts obtained from this plant are used to treat various diseases, including cancer. this study evaluates the anti-microbial, cytotoxic, and anti-cancer effects of different extracts of the plant. different extraction techniques were used and the resultant activities were compared. extracts of a. rupestris were prepared from the flowers plus the leaves and from the stems. the antimicrobial activity against candida albicans and ... | 2017 | 28569514 |
| antimicrobial and anti-biofilm properties of polypropylene meshes coated with metal-containing dlc thin films. | a promising strategy to reduce nosocomial infections related to prosthetic meshes is the prevention of microbial colonization. to this aim, prosthetic meshes coated with antimicrobial thin films are proposed. commercial polypropylene meshes were coated with metal-containing diamond-like carbon (me-dlc) thin films by the magnetron sputtering technique. several dissimilar metals (silver, cobalt, indium, tungsten, tin, aluminum, chromium, zinc, manganese, tantalum, and titanium) were tested and com ... | 2017 | 28560581 |
| chemical composition and antimicrobial activities of iranian propolis | with considering the importance of natural products for their remedial and therapeutic value, this research was aimed to analyze the chemical compositions and antimicrobial activity of four propolis samples from different areas of iran (chenaran, taleghan, morad beyg, and kalaleh) with various climates and flora. | 2017 | 28558440 |
| fabrication of denture base materials with antimicrobial properties. | acrylic resin denture base resins are colonized by oral and nonoral bacteria and candida species. this reservoir of microorganism causes denture stomatitis, which can be implicated in some life-threating infections in older denture wearers. | 2017 | 28552288 |
| investigation of antioxidant, antimicrobial and toxicity activities of lichens from high altitude regions of nepal. | several lichen species are reported to be used tradiationally in many theraupatic practices. many lichen species are reported as sources of several bioactive natural compounds. several lichen species of nepal are so far chemically unexplored. | 2017 | 28545438 |
| relative susceptibility of airway organisms to antimicrobial effects of nitric oxide. | nitric oxide (no) is released in the airway as a critical component of innate immune defense against invading pathogenic organisms. it is well documented that bacteriostatic and bactericidal effects of no are concentration-dependent. however, few data exist comparing relative susceptibility of common pathogens to no at physiologic concentrations. in this study we evaluated the effects of no on 4 common airway bacteria and 1 fungus, and examined the potential implications of discrepancies in sens ... | 2017 | 28544570 |
| effectiveness of non-fluoride and fluoride dentifrices for denture hygiene. | to compare the effectiveness of commonly used herbal/non-fluoride with fluoride dentifrices in order to eliminate pathogenic oral microorganisms from denture base material. | 2017 | 28539095 |
| green synthesis of silver nanoparticles using mentha pulegium and investigation of their antibacterial, antifungal and anticancer activity. | a simple and eco-friendly method for efficient synthesis of stable colloidal silver nanoparticles (agnps) using mentha pulegium extracts is described. a series of reactions was conducted using different types and concentrations of plant extract as well as metal ions to optimize the reaction conditions. agnps were characterized by using uv-vis spectroscopy, transmission electron microscopy, atomic force microscopy, dynamic light scattering, zetasizer, energy-dispersive x-ray spectroscopy (edax) a ... | 2017 | 28530184 |
| application of hyperosmotic nanoemulsions in wound healing: partial thickness injury model in swine. | objective: in this work, we introduce a novel hyperosmotic nanoemulsion (hne) topical agent for use in wound healing. these topical emulsion complexes combine a lipophilic thymol nanoemulsion with a hyperosmotic saccharide matrix. this combination has been previously shown to possess synergistic antimicrobial activity against a host of common and drug-resistant pathogens in vitro. approach: in this study, we present additional data to assess the safety and efficacy of these emulsions in a partia ... | 2017 | 28507786 |
| microbiological analysis of acute infections of the nail fold on the basis of bait thread test. | an acute infection of the nail fold, called paronychia, is a common clinical problem. the basis for the implementation of the treatment is the result of microbiological examination. due to the rapid and painful course of infection, usually an empirical antimicrobial treatment prior to obtaining microbiological test results is introduced. | 2017 | 28507488 |
| broad spectrum macromolecular antimicrobials with biofilm disruption capability and in vivo efficacy. | in this study, antimicrobial polymers are synthesized by the organocatalytic ring-opening polymerization of an eight-membered heterocyclic carbonate monomer that is subsequently quaternized with methyl iodide. these polymers demonstrate activity against clinically relevant gram-positive staphylococcus epidermidis and staphylococcus aureus, gram-negative escherichia coli and pseudomonas aeruginosa, and fungus candida albicans with fast killing kinetics. importantly, the polymer efficiently inhibi ... | 2017 | 28504348 |
| salvia officinalis l. essential oils from spain: determination of composition, antioxidant capacity, antienzymatic, and antimicrobial bioactivities. | four essential oils (eos) from salvia officinalis l. cultivated in spain (murcia province) were analyzed by gas chromatography coupled with mass spectrometry (gc/ms) to determine their relative and absolute compositions. the main components were α-thujone (22.8 - 41.7%), camphor (10.7 - 19.8%), 1,8-cineole (4.7 - 15.6%), and β-thujone (6.1 - 15.6%). enantioselective gas chromatography identified (-)-α-thujone and (+)-camphor as the main enantiomers in all the analyzed eos. furthermore, when the ... | 2017 | 28477412 |
| synthesis and in vitro biological evaluation of novel coumarin derivatives containing isoxazole moieties on melanin synthesis in b16 cells and inhibition on bacteria. | a novel series of coumarin derivatives 6a-o, bearing isoxazole moieties were designed and synthesized. after that, they were evaluated for melanin synthesis in murine b16 cells and inhibitory effect on the growth of ca (candida albicans), ec (escherichia coli), sa (staphylococcus aureus). it was found that eleven compounds (6b-f, 6j-o) showed a better activity on melanin synthesis than positive control (8-mop). among them, compounds 6d (242%) and 6f (390%), with nearly 1.6 and 2.6-fold potency c ... | 2017 | 28476568 |
| effects of time and extraction temperature on phenolic composition and functional properties of red rooibos (aspalathus linearis). | this work was aimed at assessing the time-temperature effects on the phenolic compounds and in vitro functional properties of aqueous extracts from red rooibos (aspalathus linearis). the major phenolic composition (tannins, flavonoids, flavonols, ortho-diphenols, total phenolic content), antioxidant (abts and dpph) and reducing capacities (frap and total reducing capacity), antimicrobial effects and inhibition of α-amylase/α-glucosidase were measured. phenolic compounds were also determined by l ... | 2016 | 28460941 |
| healing potential of zerumbone ointment on experimental full-thickness excision cutaneous wounds in rat. | zerumbone is a monocyclic sesquiterpene compound. based on report, it is the predominant bioactive compound from the rhizomes of zingiber zerumbet. the study was undertaken to evaluate the therapeutic effects of topical zerumbone on excision wounds in rats. a 1% (w/w) simple ointment containing zerumbone was applied topically (100 mg ointment per rat) once a day on full-thickness excision wounds created on rats. the wound tissue was removed and used for estimation of antioxidant activity and to ... | 2017 | 28454680 |
| potassium iodide potentiates antimicrobial photodynamic inactivation mediated by rose bengal in in vitro and in vivo studies. | rose bengal (rb) is a halogenated xanthene dye that has been used to mediate antimicrobial photodynamic inactivation for several years. while rb is highly active against gram-positive bacteria, it is largely inactive in killing gram-negative bacteria. we have discovered that addition of the nontoxic salt potassium iodide (100 mm) potentiates green light (540-nm)-mediated killing by up to 6 extra logs with the gram-negative bacteria escherichia coli and pseudomonas aeruginosa, the gram-positive b ... | 2017 | 28438946 |
| synthesis, characterization, antimicrobial and antiproliferative activity evaluation of cu(ii), co(ii), zn(ii), ni(ii) and pt(ii) complexes with isoniazid-derived compound. | hydrazone complexes of cu(ii), co(ii), zn(ii), ni(ii) and pt(ii) with n-isonicotinoyl-n'-(3-metoxy-2 hydroxybenzaldehyde)-hydrazone (hl) were synthesized and characterized by different physico-chemical techniques including elemental and thermal analysis, magnetic susceptibility measurements, molar electric conductivity, as well as ir (infrared), ¹h-nmr and (13)c-nmr (hydrogen and carbon nuclear magnetic resonance, uv-vis (ultraviolet-visible), fab (fast atom bombardment), epr (electron paramagne ... | 2017 | 28422067 |
| zinc ion coordinated poly(ionic liquid) antimicrobial membranes for wound healing. | herein, a series of quaternary ammonium (qa) or imidazolium (im) cation-based poly(ionic liquid) (pil) membranes and their corresponding zinc ion coordinated pil membranes were synthesized. the effects of chemical structure, including organic cations, alkyl side chain of substitution, and zinc atoms on the antimicrobial activities against escherichia coli, staphylococcus aureus, and candida albicans were investigated. the zn-containing pil membranes show higher antibacterial activities compared ... | 2017 | 28418650 |
| tmcactin plays an important role in gram-negative and -positive bacterial infection by regulating expression of 7 amp genes in tenebrio molitor. | cactin was originally identified as an interactor of the drosophila iκb factor cactus and shown to play a role in controlling embryonic polarity and regulating the nf-κb signaling pathway. while subsequent studies have identified the roles for cactin in the mammalian immune response, the immune function of cactin in insects has not been described yet. here, we identified a cactin gene from the mealworm beetle, tenebrio molitor (tmcactin) and characterized its functional role in innate immunity. ... | 2017 | 28418029 |
| electrospun fiber pads of cellulose acetate and essential oils with antimicrobial activity. | the method of electrospinning was used to create nanofibers made of cellulose acetate (ca) and essential oils (eos). ca polymer at 15% w/v was dissolved in acetone and then 1% or 5% v/v of eos was added to the polymer solution. the utilized essential oils were rosemary and oregano oils. then, the ca/eos in acetone solution were electrospun, creating micro/nanofibers, approximately 700-1500 nm in diameter. raman spectroscopy was used to detect the attachment of the eos in the ca electrospun fiber ... | 2017 | 28417912 |
| the naturally occurring host defense peptide, ll-37, and its truncated mimetics ke-18 and kr-12 have selected biocidal and antibiofilm activities against candida albicans, staphylococcus aureus, and escherichia coli in vitro. | amongst the recognized classes of naturally occurring antimicrobials, human host defense peptides are an important group with an advantage (given their source) that they should be readily translatable to medicinal products. it is also plausible that truncated versions will display some of the biological activities of the parent peptide, with the benefit that they are less costly to synthesize using solid-phase chemistry. the host defense peptide, ll-37, and two truncated mimetics, ke-18 and kr-1 ... | 2017 | 28408902 |
| effect of storage in distilled water for three months on the antimicrobial properties of poly(methyl methacrylate) denture base material doped with inorganic filler. | the colonization of poly(methyl methacrylate) (pmma) denture base materials by pathogenic microorganisms is a major problem associated with the use of prostheses, and the incorporation of antimicrobial fillers is a method of improving the antimicrobial properties of these materials. numerous studies have demonstrated the initial in vitro antimicrobial effectiveness of this type of material; however, reports demonstrating the stability of these fillers over longer periods are not available. in th ... | 2016 | 28773451 |
| potentiating antimicrobial efficacy of propolis through niosomal-based system for administration. | propolis is a multicomponent active, complex resinous substance collected by honeybees (apis mellifera) from a variety of plant sources. this study was designed to improve the antimicrobial efficacy of propolis by engineering a niosomal-based system for topical application. | 2015 | 28664114 |
| initial bacterial adhesion on different yttria-stabilized tetragonal zirconia implant surfaces in vitro. | bacterial adhesion to implant biomaterials constitutes a virulence factor leading to biofilm formation, infection and treatment failure. the aim of this study was to examine the initial bacterial adhesion on different implant materials in vitro. four implant biomaterials were incubated with enterococcus faecalis, staphylococcus aureus and candida albicans for 2 h: 3 mol % yttria-stabilized tetragonal zirconia polycrystal surface (b1a), b1a with zirconium oxide (zro₂) coating (b2a), b1a with zirc ... | 2013 | 28788415 |
| evaluation of the neutralising capacity of bactec medium for some antibiotics. | bactec medium 9240 (becton dickinson, md, usa) is a blood culture medium used routinely at sultan qaboos university hospital (squh). the medium is said to contain substances that can neutralise antibiotics and destroy leucocytes in blood samples. in this study, the ability of the medium to neutralise the effect of some antibiotics and to destroy leucocytes is investigated. vancomycin, amoxicillin, chloramphenicol, penicillin, gentamicin, fungizone and amikacin at various concentrations were adde ... | 2004 | 28696902 |
| sortase a-mediated crosslinked short-chain dehydrogenases/reductases as novel biocatalysts with improved thermostability and catalytic efficiency. | (s)-carbonyl reductase ii (scrii) from candida parapsilosis is a short-chain alcohol dehydrogenase/reductase. it catalyses the conversion of 2-hydroxyacetophenone to (s)-1-phenyl-1,2-ethanediol with low efficiency. sortase was reported as a molecular "stapler" for site-specific protein conjugation to strengthen or add protein functionality. here, we describe staphylococcus aureus sortase a-mediated crosslinking of scrii to produce stable catalysts for efficient biotransformation. via a native n- ... | 2017 | 28596548 |
| antimicrobial activity of chitosan-carbon nanotube hydrogels. | in the present study, we have prepared chitosan-carbon nanotube (chitosan-cnt) hydrogels by the freeze-lyophilization method and examined their antimicrobial activity. different concentrations of cnt were used in the preparation of chitosan-cnt hydrogels. these differently concentrated cnt hydrogels were chemically characterized using fourier transform-infrared spectroscopy, scanning electron microscopy and optical microscopy. the porosity of the hydrogels were found to be >94%. dispersion of ch ... | 2014 | 28788658 |
| blood and milk polymorphonuclear leukocyte and monocyte/macrophage functions in naturally caprine arthritis encephalitis virus infection in dairy goats. | the exact influence of caprine arthritis encephalitis virus (caev) infection on blood and milk polymorphonuclear leukocytes (pmnls) and monocyte/macrophages of goats remains unclear. thus, the present study sought to explore the blood and milk pmnl and monocyte/macrophage functions in naturally caev-infected goats. the present study used 18 healthy saanen goats that were segregated according to sera test outcomes into serologically caev negative (n=8; 14 halves) and positive (n=10; 14 halves) gr ... | 2017 | 28615124 |
| procalcitonin accurately identifies hospitalized children with low risk of bacterial community-acquired pneumonia. | lower procalcitonin (pct) concentrations are associated with reduced risk of bacterial community-acquired pneumonia (cap) in adults, but data in children are limited. | 2017 | 28158460 |
| bacterial genome sequencing in clinical microbiology: a pathogen-oriented review. | in recent years, whole-genome sequencing (wgs) has been perceived as a technology with the potential to revolutionise clinical microbiology. herein, we reviewed the literature on the use of wgs for the most commonly encountered pathogens in clinical microbiology laboratories: escherichia coli and other enterobacteriaceae, staphylococcus aureus and coagulase-negative staphylococci, streptococci and enterococci, mycobacteria and chlamydia trachomatis. for each pathogen group, we focused on five di ... | 2017 | 28639162 |
| prophylactic use of intraoperative vancomycin powder and postoperative infection: an analysis of microbiological patterns in 1200 consecutive surgical cases. | objective wound infections following spinal surgery for deformity place a high toll on patients, providers, and the health care system. the prophylactic application of intraoperative vancomycin powder has been shown to lower the infection risk after thoracolumbar decompression and fusion for deformity correction. the purpose of this study was to assess the microbiological patterns of postoperative surgical site infections (ssis) after prophylactic use of vancomycin powder in adult patients under ... | 2017 | 28665245 |
| citrobacter freundii as a cause of acute suppurative thyroiditis in an immunocompetent adult female. | acute suppurative thyroiditis (ast) is an uncommon condition, in the patients with preexisting thyroid disease or immunosuppression. the most common cause of ast is bacterial, and the most common bacteria are staphylococcus aureus, staphylococcus epidermidis, escherichia coli, and klebsiella species. due to various complications such as septicemia, septic thrombophlebitis, necrotizing mediastinitis, or pericarditis, prompt diagnosis and treatment are the keys to reduce mortality and morbidity. h ... | 2017 | 28631657 |
| the bactericidal effect of simultaneous titanium oxide on common hospital bacteria. | bacteria prevalence has increased in health centers and hospitals. infection control can decrease the number of bacteria. bacteria cause 90% of nosocomial infections and fungi, viruses, or protozoa are less involved. bacteria control can decrease the number of diseases. the simultaneous titanium oxide (smtio) is a new method of disinfection. this process degrades bacteria by producing hydroxyl radical. the present study was conducted with the aim of analyzing the bactericidal effect of simultane ... | 2017 | 28623574 |
| impact of a mixed educational and semi-restrictive antimicrobial stewardship project in a large teaching hospital in northern italy. | the overuse of antimicrobials favors the dissemination of antimicrobial resistance, as well as invasive fungal diseases and clostridium difficile infections (cdi). in this study, we assessed the impact of a mixed educational and semi-restrictive antimicrobial stewardship (ams) project in a large teaching hospital in italy. | 2017 | 28856589 |
| infection control measures and prevalence of multidrug-resistant organisms in non-hospital care settings in northeastern germany: results from a one-day point prevalence study. | much of the existing literature on the epidemiology of multidrug resistant bacterial organisms (mdros) and infection control measures still concentrates on hospital care settings. | 2017 | 28797758 |
| the potential of alcohol release doorplates to reduce surface contamination during hand contact. | optimal hand hygiene may be compromised by contact with contaminated environmental surfaces. | 2017 | 28760635 |
| response to letter of k. singh, 'role of silver nitrate in the efficacy of hydrogen peroxide aerial decontamination systems' regarding s. ali et al. 'efficacy of two hydrogen peroxide vapour aerial decontamination systems for enhanced disinfection of meticillin-resistant staphylococcus aureus, klebsiella pneumoniae and clostridium difficile in single isolation rooms'. | | 2017 | 28734723 |
| clinical characteristics and ultrasonographic findings of acute bacterial enterocolitis in children. | this study clarified the bacterial pathogens currently causing acute infectious enterocolitis (aie) in children and evaluated the clinical characteristics and ultrasonographic findings according to the different pathogens. | 2017 | 28730135 |
| risk of surgical site infection, acute kidney injury, and clostridium difficile infection following antibiotic prophylaxis with vancomycin plus a beta-lactam versus either drug alone: a national propensity-score-adjusted retrospective cohort study. | the optimal regimen for perioperative antimicrobial prophylaxis is controversial. use of combination prophylaxis with a beta-lactam plus vancomycin is increasing; however, the relative risks and benefits associated with this strategy are unknown. thus, we sought to compare postoperative outcomes following administration of 2 antimicrobials versus a single agent for the prevention of surgical site infections (ssis). potential harms associated with combination regimens, including acute kidney inju ... | 2017 | 28692690 |
| impact of moving to a new hospital build, with a high proportion of single rooms, on healthcare-associated infections and outbreaks. | clostridium difficile infection, meticillin-sensitive staphylococcus aureus (mssa) and escherichia coli bacteraemia rates, and bed-days lost during norovirus outbreaks at north bristol nhs trust were analysed over a five-year period to determine whether moving to a new-build hospital with 75% single rooms reduced healthcare-associated infection rates. c. difficile, mssa bacteraemia and e. coli bacteraemia showed no change in the rate of decline after the move. bed-days lost due to norovirus were ... | 2017 | 28666780 |
| the role of antimicrobial sutures in preventing surgical site infection. | introduction healthcare associated infections (hcais) are falling following widespread and enforced introduction of guidelines, particularly those that have addressed antibiotic resistant pathogens such as methicillin resistant staphylococcus aureus or emergent pathogens such as clostridium difficile, but no such decline has been seen in the incidence of surgical site infection (ssi), either in the uk, the eu or the us. ssi is one of the hcais, which are all avoidable complications of a surgical ... | 2017 | 28660816 |
| effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and clostridium difficile infection: a systematic review and meta-analysis. | antibiotic stewardship programmes have been shown to reduce antibiotic use and hospital costs. we aimed to evaluate evidence of the effect of antibiotic stewardship on the incidence of infections and colonisation with antibiotic-resistant bacteria. | 2017 | 28629876 |
| crystal structure of the multiple antibiotic resistance regulator marr from clostridium difficile. | regulators of multiple antibiotic resistance (marrs) are key players against toxins in prokaryotes. marr homologues have been identified in many bacterial and archaeal species which pose daunting antibiotic resistance issues that threaten public health. the continuous prevalence of clostridium difficile infection (cdi) throughout the world is associated with the abuse of antibiotics, and antibiotic treatments of cdi have limited effect. in the genome of c. difficile strain 630, the marr gene (id ... | 2017 | 28580925 |
| safety and efficacy of antibacterial prophylaxis after craniotomy: a decision model analysis. | antibiotic prophylaxis has revolutionized the safety of neurosurgical procedures in the last century. today, the clinician's drug of choice before surgery often is based on the antibiotic's resistance profile and drug-induced complications. | 2017 | 28576711 |
| carboxyl analogue of mutacin 1140, a scaffold for lead antibacterial discovery. | mutacin 1140 belongs to the epidermin group of lantibiotics. epidermin class lantibiotics are ribosomally synthesized and posttranslationally modified antibiotics with potent activity against gram-positive bacteria. in particular, this class is effective at targeting drug-resistant streptococcus pneumoniae, methicillin-resistant staphylococcus aureus (mrsa), mycobacterium tuberculosis, and clostridium difficile a c-terminal s-[(z)-2-aminovinyl]-d-cysteine (avicys) residue is derived from a decar ... | 2017 | 28500042 |
| leapfrog hospital safety score, magnet designation, and healthcare-associated infections in united states hospitals. | healthcare-associated infections (hais) pose a challenge to patient safety. although studies have explored individual level, few have focused on organizational factors such as a hospital's safety infrastructure (indicated by leapfrog hospital safety score) or workplace quality (magnet recognition). the aim of the study was to determine whether magnet and hospitals with better leapfrog hospital safety scores have fewer hais. | 2017 | 28452915 |
| how well does transfer of bacterial pathogens by culture swabs correlate with transfer by hands? | in laboratory testing and in isolation rooms, pickup and transfer of health care-associated pathogens by premoistened rayon swabs correlated well with pickup and transfer by bare hands or moistened gloves. these results suggest that swab cultures provide a useful surrogate indicator of the risk for pathogen pickup and transfer by hands. | 2017 | 28431852 |
| prospective cluster controlled crossover trial to compare the impact of an improved hydrogen peroxide disinfectant and a quaternary ammonium-based disinfectant on surface contamination and health care outcomes. | quaternary ammonium-based (quat) disinfectants are widely used, but they have disadvantages. | 2017 | 28431849 |
| colonization by multidrug-resistant organisms in long-term care facilities in italy: a point-prevalence study. | to determine prevalence and risk factors for colonization by multidrug-resistant organisms (mdros) in long-term care facility (ltcf) residents in italy. genotypes of mdro isolates were investigated. | 2017 | 28412380 |
| microbiological assessment of honey in méxico. | honey is a product used as a natural sweetener and in several regions of mexico and other countries it is also used as a therapeutic agent. microbiological contamination of honey can occur during its extraction and handling. due to the use and consumption of honey we highlighted here the importance of the assessment of its microbiological quality. one thousand nine hundred twenty samples obtained from 8 honey-producing states from mexico were analyzed. from these samples, 40.5% (777/1920) did no ... | 2017 | 28822595 |
| skin infection caused by a novel strain of staphylococcus pseudintermedius in a siberian husky dog owner. | introduction.staphylococcus pseudintermedius, an opportunistic pathogen of dogs and cats, is rarely reported to cause infection in humans. here, we describe a case of severe skin infection caused by s. pseudintermedius, in a 47-year-old male, a dog owner; to the best of our knowledge, this is the first such case reported from scotland. case presentation. the patient presented with a short history of a severe ecthyma-like lesion on his forehead, with smaller lesions on his abdomen and legs. bacte ... | 2017 | 28663821 |
| isolation of bacteria from diabetic foot ulcers with special reference to anaerobe isolation by simple two-step combustion technique in candle jar. | although polymicrobial infections involving both aerobic and anaerobic bacteria are very common in diabetic foot ulcers, in many centres of developing countries, anaerobes are rarely isolated due to technical difficulties. this can be overcome by using a new simple, innovative technique of a combination of candle combustion and use of acidified copper-coated steel wool, as reported here. | 2017 | 28574021 |
| mycobacterial panniculitis caused by mycobacterium thermoresistibile in a cat. | a domestic shorthair cat was evaluated for chronic, bilateral, ulcerative dermatitis affecting the inguinal region and lateral aspects of both pelvic limbs. histopathologic examination of skin biopsies collected throughout the course of disease revealed chronic pyogranulomatous ulcerative dermatitis. aerobic bacterial skin cultures yielded growth of a methicillin-resistant staphylococcus aureus and corynebacterium amycolatum. upon referral the clinical findings were suggestive of a non-tuberculo ... | 2017 | 28491439 |
| test characteristics of milk amyloid a elisa, somatic cell count, and bacteriological culture for detection of intramammary pathogens that cause subclinical mastitis. | bovine mastitis is an important disease in the dairy industry, causing economic losses as a result of withheld milk and treatment costs. several studies have suggested milk amyloid a (maa) as a promising biomarker in the diagnosis of mastitis. in the absence of a gold standard for diagnosis of subclinical mastitis, we estimated the diagnostic test accuracy of a commercial maa-elisa, somatic cell count (scc), and bacteriological culture using bayesian latent class modeling. we divided intramammar ... | 2017 | 28647334 |
| impact of intramammary tilmicosin infusion as a dry cow therapy. | three hundred subclinically infected quarters of 259 holstein cows infected with gram-positive bacteria were selected via quota sampling based on the california mastitis test (cmt) result and were divided randomly and equally into treatment and test groups. quarters of test group (n = 150 in 128 cows) were treated with an intramammary infusion of tilmicosin, and quarters of the control group (n = 150 in 131 cows) were treated with cloxacillin as a traditional intramammary infusion of dry cow (dc ... | 2017 | 28600854 |
| bacteriological etiology and treatment of mastitis in finnish dairy herds. | the finnish dairy herd recording system maintains production and health records of cows and herds. veterinarians and farmers register veterinary treatments in the system. milk samples for microbiological analysis are routinely taken from mastitic cows. the laboratory of the largest dairy company in finland, valio ltd., analyzes most samples using real-time pcr. this study addressed pathogen-specific microbiological data and treatment and culling records, in combination with cow and herd characte ... | 2017 | 28545485 |
| microbiological zoonotic emerging risks, transmitted between livestock animals and humans (2007-2015). | as part of the emerging risk identification (eri) activities of the european food safety authority (efsa), a literature search was conducted to identify the microbiological agents transmitted between livestock animals and humans that have been suggested as having emerged between 2007 and 2015 in peer-reviewed scientific literature published during the same period (2007-2015). according to the criteria set, the search identified seven such zoonotic agents, namely west nile fever virus, rift valle ... | 2017 | 28670863 |
| exploitation of spr to investigate the importance of glycan chains in the interaction between lactoferrin and bacteria. | bovine lactoferrin (lf) has been shown to prevent adhesion to and invasion of mammalian cell lines by pathogenic bacteria, with evidence for direct bacterial binding by the milk glycoprotein. however, the glycosylation pattern of lf changes over the lactation cycle. in this study, we aim to investigate the effect that this variation has on the milk glycoprotein's ability to interact with pathogens. surface plasmon resonance technology was employed to compare the binding of lf from colostrum (ear ... | 2017 | 28653977 |
| depsidones and an α-pyrone derivative from simpilcillium sp. psu-h41, an endophytic fungus from hevea brasiliensis leaf. | nine previously undescribed depsidones (simplicildones a-i) and one previously undescribed α-pyrone (simplicilopyrone) were isolated from the endophytic fungus simplicillium sp. psu-h41 along with 11 known compounds. their structures were established by extensive spectroscopic analysis. simplicildone a and known botryorhodine c displayed weak antibacterial against staphylococcus aureus with equal mic values of 32 μg/ml. additionally, botryorhodine c was active against methicillin-resistant s. au ... | 2017 | 28803995 |
| evaluation of anti-inflammatory and antimicrobial activity of ahpl/aycap/0413 capsule. | conventional therapeutic agents used for treatment of acne are associated with various adverse effects necessitating development of safe and effective alternative therapeutic agents. in this context, a polyherbal formulation ahpl/aycap/0413 was developed for treatment of acne. | 2017 | 28827969 |
| conjunctival bacteria flora of glaucoma patients during long-term administration of prostaglandin analog drops. | to investigate the effects of the long-term use of prostaglandin analogs for glaucoma treatment on the indigenous flora of the conjunctiva. | 2017 | 28796877 |
| commercial essential oils as potential antimicrobials to treat skin diseases. | essential oils are one of the most notorious natural products used for medical purposes. combined with their popular use in dermatology, their availability, and the development of antimicrobial resistance, commercial essential oils are often an option for therapy. at least 90 essential oils can be identified as being recommended for dermatological use, with at least 1500 combinations. this review explores the fundamental knowledge available on the antimicrobial properties against pathogens respo ... | 2017 | 28546822 |
| reduction in bacterial load using hypochlorous acid hygiene solution on ocular skin. | to examine the magnitude of bacterial load reduction on the surface of the periocular skin 20 minutes after application of a saline hygiene solution containing 0.01% pure hypochlorous acid (hocl). | 2017 | 28458509 |
| bactericidal potential of silver nanoparticles synthesized using cell-free extract of comamonas acidovorans: in vitro and in silico approaches. | the need to overcome human threats from pathogenic microbes, development of nanomaterials have been provoked for a new generation of antimicrobials. in the present study, biosynthesis of silver nanoparticles (agnps) was acquired using comamonas acidovorans extract within 72 h under static condition. electron microscopy studies revealed that the size of agnps was ranging from 6-53 nm and had spherical, oval and irregular shapes with smooth surfaces. prepared agnps interacted with proteins, carboh ... | 2017 | 28555428 |
| eco-friendly fabrication of ag nanostructures using the seed extract of pedalium murex, an ancient indian medicinal plant: histopathological effects on the zika virus vector aedes aegypti and inhibition of biofilm-forming pathogenic bacteria. | the control of zika virus mosquito vectors and well as the development of drugs in the fight against biofilm-forming microbial pathogens, are timely and important challenges in current bionanoscience. here we focused on the eco-friendly fabrication of ag nanostructures using the seed extract of pedalium murex, an ancient indian medicinal plant. initial confirmation of ag nanoparticles (agnps) production was showed by a color change from transparent to dark brown. the uv-visible spectrum (476nm), ... | 2017 | 28772238 |
| participation of 14-3-3ε and 14-3-3ζ proteins in the phagocytosis, component of cellular immune response, in aedes mosquito cell lines. | better knowledge of the innate immune system of insects will improve our understanding of mosquitoes as potential vectors of diverse pathogens. the ubiquitously expressed 14-3-3 protein family is evolutionarily conserved from yeast to mammals, and at least two isoforms of 14-3-3, the ε and ζ, have been identified in insects. these proteins have been shown to participate in both humoral and cellular immune responses in drosophila. as mosquitoes of the genus aedes are the primary vectors for arbov ... | 2017 | 28764795 |
| enhanced larvicidal, antibacterial, and photocatalytic efficacy of tio2 nanohybrids green synthesized using the aqueous leaf extract of parthenium hysterophorus. | titanium dioxide nanoparticles are emerging as a biocompatible nanomaterial with multipurpose bioactivities. in this study, titanium dioxide (tio2) nanoparticles were effectively synthesized using the aqueous leaf extracts of parthenium hysterophorus prepared by microwave irradiation. tio2 nanoparticles were fabricated by treating the p. hysterophorus leaf extracts with the tio4 solution. biologically active compounds such as alcohols, phenols, alkanes, and fluoroalkanes were involved in bioredu ... | 2017 | 28537028 |