| a comparison of the in vitro and in vivo effects of erythromycin, penicillin, and oxytetracycline against resistant staphylococci. | | 1955 | 24543773 |
| growth of the versatile staphylococci. ii. effect of subminimal concentrations of penicillin or oxytetracycline on the growth of sensitivite, resistant, and mixture of sensitivite and resistant staphylococci in a semisynthetic medium as compared with veal infusion medium. | | 1955 | 24543704 |
| growth of the versatile staphylococci. i. effect of preformed purines, pyrimidines, and essential vitamins in the presence or absence of subminimal inhibitory concentrations of penicillin or oxytetracycline in a semisynthetic medium. | | 1955 | 24543703 |
| erythromycin sensitivity of micrococcus pyogenes var. aureus in a hospital population (development of resistance). | | 1955 | 24543667 |
| resistance as a problem in antibiotic therapy. | | 1955 | 24543520 |
| the assay of antibiotics in combination using resistant strains of micrococcus pyognes var. aureus. | | 1955 | 24543472 |
| action of erythromycin alone and associated with oxytetracycline and penicillin on staphylococcus aureus. | | 1954 | 24543273 |
| altered growth requirements accompanying chloramphenicol resistance in micrococcus pyogenes var. aureus. | | 1954 | 24543027 |
| relation of antibiotic resistance of staphylococci to prevalence of antibiotic therapy in diverse geographic areas. | | 1954 | 24542946 |
| genetic studies on microbial cross resistance to toxic agents. ii. cross resistance of micrococcus pyogenes var. aureus to thirty-four antimicrobial drugs. | | 1953 | 24542854 |
| bacterial susceptibility to antibiotics. v. relative susceptibility of staphylococci and enterococci to erythromycin, carbomycin and a combination of chlortetracycline and chloramphenicol. | | 1953 | 24542703 |
| natural and artificial penicillin resistance in staphylococcus (micrococcus pyogenes var. aureus). | | 1953 | 24542648 |
| changing pattern of resistance of staphylococci to antibiotics. | | 1953 | 24542585 |
| comparative studies on the phosphorus metabolism of staphylococci in the presence of chlortetracycline and oxytetracycline. | | 1953 | 24542584 |
| the antibiotic-resistant staphylococci. | | 1953 | 24542678 |
| antibiotic synergism and staphylococcus aureus. | | 1952 | 24542155 |
| [treatment of acute osteomyelitis caused by staphylococcus aureus]. | | 1949 | 15392272 |
| a comparative study of oral microbiota in infants with complete cleft lip and palate or cleft soft palate. | few reports have been published on the early microbiota in infants with various types of cleft palate. we assessed the formation of the oral microbiota in infants with complete cleft lip and palate (clp n = 30) or cleft soft palate (csp n = 25) in the neonatal period (t1 time) and again in the gum pad stage (t2 time). culture swabs from the tongue, palate, and/or cleft margin at t1 and t2 were taken. we analysed the prevalence of the given bacterial species (the percentage) and the proportions i ... | 2017 | 28393073 |
| evidence for the evolutionary steps leading to meca-mediated β-lactam resistance in staphylococci. | the epidemiologically most important mechanism of antibiotic resistance in staphylococcus aureus is associated with meca-an acquired gene encoding an extra penicillin-binding protein (pbp2a) with low affinity to virtually all β-lactams. the introduction of meca into the s. aureus chromosome has led to the emergence of methicillin-resistant s. aureus (mrsa) pandemics, responsible for high rates of mortality worldwide. nonetheless, little is known regarding the origin and evolution of meca. differ ... | 2017 | 28394942 |
| fatal swine influenza a h1n1 and mycoplasma pneumoniae coinfection in a child. | one of the most common causes of death in influenza patients is secondary bacterial pneumonia and the most common pathogens involved are streptococcus pneumoniae, staphylococcus aureus, and haemophilus influenza. to diagnose co infection with bacteria in a h1n1 case can be difficult but should be strongly suspected in a child who present with influenza like illness and lower respiratory tract signs or symptoms. we report coinfection of mycoplasma pneumoniae in swine influenza a h1n1 child who pr ... | 2016 | 28393730 |
| methanolic extract of plumbago zeylanica - a remarkable antibacterial agent against many human and agricultural pathogens. | the current investigation was carried out to determine the cytotoxic and the antimicrobial activities of methanolic extracts of plumbago zeylanica. | 2017 | 28392958 |
| a novel restraint device for injection of galleria mellonella larvae that minimizes the risk of accidental operator needle stick injury. | larvae of the insect galleria mellonella are increasingly being used for studying pathogenic microbes and their virulence mechanisms, and as a rapid model for screening novel antimicrobial agents. the larvae (waxworms) are most frequently infected by injection of pathogenic organisms into the haemocoel through the insect's prolegs. the mostly widely used method for restraining the waxworms for injection is by grasping them between the operator's fingers, which puts the operator at risk of needle ... | 2017 | 28401069 |
| physicochemical characterization of water-soluble chitosan derivatives with singlet oxygen quenching and antibacterial capabilities. | new water-soluble chitosan derivatives (wsch) were obtained by maillard reaction (mr) between glucosamine (ga) with both low and medium molecular weight chitosans (ch). the wsch showed larger solubility than the respective ch, while their deacetylation degree (dd) decreased by approximately 12%. infrared spectroscopy experiments of wsch confirmed the formation of imine bonds after mr with intensified pyranose structure, and sugar molecules as polymer branches. however, a 6-times reduction of the ... | 2017 | 28396271 |
| antibacterial secondary metabolites from an endophytic fungus, fusarium solani jk10. | extensive chemical investigation of the endophytic fungus, fusarium solani jk10, harbored in the root of the ghanaian medicinal plant chlorophora regia, using the osmac (one strain many compounds) approach resulted in the isolation of seven new 7-desmethyl fusarin c derivatives (1-7), together with five known compounds (8-12). the structures of the new compounds were elucidated by analysis of their spectroscopic data including 1d, 2d nmr, hresi-ms(n) and ir data. the relative configuration of co ... | 2017 | 28392268 |
| [antimicrobial sensitivity of the environmental microbiota in the intensive care units of a peruvian hospital]. | the objective was to detect gram-negative bacilli and gram-positive cocci isolated from the environmental microbiota of the intensive care unit (icu) departments of neonatology, pediatrics, and transplants (kidney, liver, and general) in a lima hospital and determine their antimicrobial sensitivity. eighty samples were obtained from inanimate surfaces using a wet swab. a total of 61 bacterial strains were identified, including staphylococcus epidermis (46.0%), alcaligenes sp. (21.3%), pseudomona ... | 2017 | 28538851 |
| ultraviolet-c light as a means of disinfecting anesthesia workstations. | anesthesia workstations (aws) are a reservoir for pathogenic organisms potentially associated with surgical site infections. this study examined the effectiveness of the tru-d smartuvc device (tru-d llc, nashville, tn) on bioburden reduction (br) on aws. | 2017 | 28431851 |
| ag nanoparticle-coated zirconia for antibacterial prosthesis. | bacterial adhesion to dental materials is a major cause of caries and periodontitis, necessitating the development of compounds such as yttria-stabilized zirconia (ysz) and silver nanoparticles (agnps), which are widely employed in medicine due to their high antimicrobial activity and low cytotoxicity. the main goal of this study is the synthesis of the broad antimicrobial activity of agnp-coated ysz with facile methods. the bactericidal agnps were immobilized on the surface of ysz and tested fo ... | 2017 | 28575940 |
| validity of somatic cell count as indicator of pathogen-specific intramammary infections. | the objective of this study was to determine whether somatic cell count (scc) was an effective test, with a sensitivity exceeding 85%, to determine species-specific bacterial infections. in addition, the relation between the scc and various udder pathogen groups was investigated. scc thresholds of greater than 200 000 cells/ml were used in quarter and greater than 150 000 cells/ml in composite milk samples. a retrospective study was conducted on a data set for 89 635 quarter and 345 467 composit ... | 2017 | 28470079 |
| diversity of endophytic bacteria in a fern species dryopteris uniformis (makino) makino and evaluation of their antibacterial potential against five foodborne pathogenic bacteria. | the fern plant dryopteris uniformis has traditionally been used in herbal medicine and possesses many biological activities. this study was conducted to explore the endophytic bacterial diversity associated with d. uniformis and evaluate their antibacterial potential against foodborne pathogenic bacteria (fpb). among 51 isolated endophytic bacteria (eb), 26 eb were selected based on their morphological characteristics and identified by 16s rrna gene analysis. the distribution of eb was diverse i ... | 2017 | 28418717 |
| chemical constituents of helichrysum italicum (roth) g. don essential oil and their antimicrobial activity against gram-positive and gram-negative bacteria, filamentous fungi and candida albicans. | the aerial parts of helichrysum italicum (roth) g. don were subjected to hydrodistillation to obtain essential oils which had been analyzed by gas chromatography and gas chromatography coupled with mass spectrometry and tested for antimicrobial activity against 12 bacteria, two yeasts and four fungi by agar diffusion method. the essential oil yielded 0.44% (v/w) and 67 compounds accounting for 99.24% of the oil were identified with a high content of oxygenated sesquiterpenes (61.42%). the most o ... | 2017 | 28725151 |
| investigation on the antimicrobial activities of gingers (etlingera coccinea (blume) s.sakai & nagam and etlingera sessilanthera r.m.sm.) endemic to borneo. | to investigate the antimicrobial properties of e. coccinea and e. sessilanthera and to isolate and identify the antimicrobial compounds. | 2017 | 28708293 |
| development and characterization of bioactive edible films from spider crab (maja crispata) chitosan incorporated with spirulina extract. | active food packaging films based on crab chitosan and spirulina extract (se) were developed. the effects of the se incorporation at different levels on physical (color, opacity water vapor and oxygen permeability) and mechanical (tensile strength and elongation at break) properties of chitosan films were investigated. ftir was carried out to observe the potential modifications of the chitosan films when incorporated with se. the obtained results suggested that incorporation of se into chitosan ... | 2017 | 28705500 |
| identification, bioactivity, and productivity of actinomycins from the marine-derived streptomyces heliomycini. | in the process of profiling the secondary metabolites of actinobacteria isolated from the saudi coastal habitats for production of antibiotics and anti-cancer drugs, the cultures of strain wh1 that was identified as streptomyces heliomycini exhibited strong antibacterial activity against staphylococcus aureus. by means of ms and nmr techniques, the active compounds were characterized as actinomycins x0β, x2, and d, respectively. the research on the productivity of this strain for actinomycins re ... | 2017 | 28702007 |
| antituberculotic activity of actinobacteria isolated from the rare habitats. | a distinctive screening procedure resulted in the isolation and identification of antituberculotic actinobacteria. in this course, a total of 125 actinobacteria were isolated from various soil samples from untapped areas in northwestern himalayas, india. the antibacterial screening showed that 26 isolates inhibited the growth of at least one of the tested bacterial pathogens including staphylococcus aureus (atcc 25923), staphylococcus epidermidis (atcc 12228), bacillus subtilis (atcc 11774), mic ... | 2017 | 28699251 |
| isolation and antibiotic screening of fungi from a hydrothermal vent site and characterization of secondary metabolites from a penicillium isolate. | five new compounds were isolated from penicillium sp. y-5-2 including an austin derivative 4, four isocoumarins 9, 11, 12, and 13, together with two known isocoumarins 8 and 10, and six known austin derivatives 1, 2, 3, 5, 6, and 7 and one phenol 14. their structures and relative configurations were established by spectroscopic means. the absolute configurations of 4, 11, and 13 were defined mainly by comparison of quantum chemical tddft calculated and experimental ecd spectra. the cyclization o ... | 2017 | 28698959 |
| antibacterial and antioxidant constituents of extracts of endophytic fungi isolated from ocimum basilicum var. thyrsiflora leaves. | fourteen fungal endophytes were isolated from the ocimum basilicum var. thyrsiflora leaves collected from northern thailand. eight genera were identified including aspergillus, ascochyta, nigrospora, blastomyces, colletotrichum, exidia, clitopilus, and nomuraea. the antibacterial activity of crude extracts from all endophytic fungi was tested against nine human bacterial pathogens: staphylococcus aureus, staphylococcus epidermidis, bacillus subtilis, bacillus cereus, escherichia coli, klebsiella ... | 2017 | 28698913 |
| in vitro imaging of bacteria using (18)f-fluorodeoxyglucose micro positron emission tomography. | positron emission tomography (pet) with fluorine-18-fluorodeoxyglucose ((18)f-fdg) can be applied to detect infection and inflammation. however, it was so far not known to what extent bacterial pathogens may contribute to the pet signal. therefore, we investigated whether clinical isolates of frequently encountered bacterial pathogens take up (18)f-fdg in vitro, and whether fdg inhibits bacterial growth as previously shown for 2-deoxy-glucose. 22 isolates of gram-positive and gram-negative bacte ... | 2017 | 28694519 |
| novel fibrous collagen-based cream accelerates fibroblast growth for wound healing applications: in vitro and in vivo evaluation. | the present study reports the development of a novel film-forming bovine collagenous cream (bcc) based on bovine collagen (bc). in this study, collagen was isolated from bovine forestomach tissue, a novel source, and a cream formulation was prepared using some other bioactive ingredients. the electrophoretic pattern of the bc was found to be similar to type i collagen. the purity of bc was examined by amino acid analysis, which confirmed the presence of atelocollagen. the physicochemical propert ... | 2017 | 28676877 |
| polyketide derivatives from a marine-sponge-associated fungus pestalotiopsis heterocornis. | twelve previously undescribed polyketide derivatives, heterocornols a-l, and seven known analogues were isolated from a culture of the fungus pestalotiopsis heterocornis associated with sponge. their structures were elucidated by a comprehensive spectroscopic data analysis and cd cotton effects. these compounds were evaluated for cytotoxic and antibacterial activities in vitro. among them, heterocornols a-c, f-h, methyl-(2-formyl-3-hydroxyphenyl)propanoate, agropyrenol, and vaccinol g exhibited ... | 2017 | 28675830 |
| synthesis and characterization of zro2 nanoparticles-antimicrobial activity and their prospective role in dental care. | nanomaterials are exerting a pull on deal with biological and pharmaceutical applications. biomedical grade of zirconia reveals potential mechanical features of oxide ceramics. in this study, antimicrobial activity and anti-tooth decay applications of the synthesized nps of zro2 were determined. the as-prepared zro2 nps were characterized by uv-vis spectroscopy, ftir and xrd, which determined the formation of zro2nps and their crystalline nature. sem analysis further revealed spherical shaped np ... | 2017 | 28666841 |
| three new abietane-type diterpenoids from plectranthus africanus and their antibacterial activities. | three new abietane-type diterpenoids, plectranthroyleanones a - c (1 - 3), together with five known compounds (4 - 8) were isolated from the methanol extract of the whole plant of plectranthus africanus using column chromatography techniques. the structures of the new compounds were elucidated using a combination of 1d and 2d nmr and hresims analyses. compound 1 exhibited weak activities with minimal inhibitory concentration values of 75 µg/ml against gram-positive bacteria, bacillus subtilis an ... | 2017 | 28662528 |
| innovative non-thermal plasma disinfection process inside sealed bags: assessment of bactericidal and sporicidal effectiveness in regard to current sterilization norms. | in this work, we developed a device capable to generate a non-thermal plasma discharge inside a sealed bag. the aim of this study was to assess the effectiveness of the oxygen, nitrogen and argon plasma sterilization on pseudomonas aeruginosa, staphylococcus aureus and bacillus subtilis spores according to the nf en 556 norm. moreover the bag integrity which is a critical key to maintain the sterile state of items after the end of the process was verified by fourier transform infrared (ftir) and ... | 2017 | 28662202 |
| fluoro-carba-sugars are glycomimetic activators of the glms ribozyme. | the glms ribozyme is a bacterial gene-regulating riboswitch that controls cell wall synthesis, depending on glucosamine-6-phosphate as a cofactor. due to the presence of this ribozyme in several human pathogen bacteria (e.g. mrsa, vrsa), the glms ribozyme represents an attractive target for the development of artificial cofactors. the substitution of the ring oxygen in carbohydrates by functionalized methylene groups leads to a new generation of glycomimetics that exploits distinct interaction p ... | 2017 | 28661578 |
| identification and growth optimization of a marine bacillus dk1-sa11 having potential of producing broad spectrum antimicrobial compounds. | control of harmful bacteria in food, aquaculture, pharmaceuticals, agriculture, hospitals and recreation water pools are of great global concern. marine bacteria are an enormous source of bio-controlling agents. the aim of this study was to identify and optimize the growth conditions including effect of different biotic and abiotic factors on antimicrobial activity of strain dk1-sa11 isolated from qingdao bay of china yellow sea. microscopic characterization, api® 20e and 50 chb kit base carbohy ... | 2017 | 28653930 |
| screening of leaves extracts from calamus aromaticus for their antimicrobial activity by disc diffusion assay. | the current research investigates the anti-microbial activities of different solvent extracted samples from the leaves of calamus aromaticus against gram positive, gram negative bacteria and fungi using 500, 1000 and 2000 μg disc(-1) concentrations. escherichia coli, citorbacter freundii and candida albicans showed resistivity to crude methanolic extract and the same microbes were more susceptible to water extracted fractions. maximum activity was measured by hexane extracted fractions against p ... | 2017 | 28653924 |
| kitchen phytochemicals from allium cepa - their role in multidrug resistance. | bacterial resistance to antibiotics is increasingly becoming a concern to public health. current antibiotics have failed to bring desirable results to many bacterial infections due to multi-resistant strains. so, concerted efforts are being made to curve this with the help of dietary phytohemicals. a number of dietary phytochemical are being put to trials for antimicrobial activity; however it is worthwhile to search such a part of diet that is very frequently used by major population. keeping t ... | 2017 | 28653923 |
| evaluation of anti-oxidative, antimicrobial and anti-diabetic potential of adiantum venustum and identification of its phytochemicals through gc-ms. | the present study aimed to explore antioxidant, antimicrobial and anti-diabetic properties of the fern adiantum venustum. the tpc (total phenolic content) of methanolic extract of the plant was 247.95±0.0007μg of gallic acid equivalents per gram of dried extract (mg gae/g). the highest tpc was in n-butanolic fraction, which was 981.45±0.1562mg gae/g. hexane fraction showed lowest tpc (256.95±0.0420mg gae/g). ethyl acetate fraction exhibited highest total flavonoid content (tfc), i.e., 62.0±0.050 ... | 2017 | 28653913 |
| 1,1ꞌ-carbonyldiimidazole (cdi) mediated facile synthesis, structural characterization, antimicrobial activity and in-silico studies of coumarin-3-carboxamide derivatives. | despite of the availability of variety of antibacterial agents, re-emergance of pathogenic bacteria is still a serious medical concern. so, identification of new, safer, and selective antibacterial agents is the key interest in the medicinal chemistry research. | 2017 | 28641525 |
| chemical composition and biological activities of leaf and fruit essential oils from eucalyptus camaldulensis. | the chemical composition of the essential oils from the leaves and fruit of eucalyptus camaldulensis grown in mersin, turkey was analyzed using gas chromatography (gc) and gas chromatography-mass spectrometry (gc-ms) techniques. the biological activities (antibacterial and antifungal) were examined using the agar well diffusion method. the main leaf oil constituents were p-cymene (42.1%), eucalyptol (1,8-cineole) (14.1%), α-pinene (12.7%) and α-terpinol (10.7%). the main constituents of the frui ... | 2017 | 28640755 |
| coumarin-benzimidazole hybrids as a potent antimicrobial agent: synthesis and biological elevation. | molecular hybridization approach is an emerging tool in drug discovery for designing new pharmacophores with biological activity. a novel, new series of coumarin-benzimidazole hybrids were designed, synthesized and evaluated for their broad spectrum antimicrobial activity. among all the synthesized molecules, compound (e)-3-(2-1h-benzo[d]imidazol-1-yl)-1-((4-chlorobenzyl)oxy)imino)ethyl)-2h-chromen-2-one showed the most promising broad spectrum antibacterial activity against pseudomonas aerugino ... | 2017 | 28634338 |
| antibacterial and antifungal activities of spices. | infectious diseases caused by pathogens and food poisoning caused by spoilage microorganisms are threatening human health all over the world. the efficacies of some antimicrobial agents, which are currently used to extend shelf-life and increase the safety of food products in food industry and to inhibit disease-causing microorganisms in medicine, have been weakened by microbial resistance. therefore, new antimicrobial agents that could overcome this resistance need to be discovered. many spices ... | 2017 | 28621716 |
| synthesis of new thiazolyl coupled pyrazoles bearing 2,4-thiazolidinedionyl pharmacophore and their anti-inflammatory and antibacterial evaluation. | 2, 4-thiazolidinedione (tzd), pyrazole and thiazole heterocyclic rings exhibit wide range of pharmacological activities. medicinal chemists use these heterocyclic moieties as scaffolds in drug designing and discovery. the existing medicaments, celecoxib and meloxicam, used for treating inflammation and pain are having, pyrazole and thiazole, respectively as a key scaffolds. pyrazoles coupled with 2, 4-thiazolidinediones may display enhanced anti inflammatory activity. with this hope the title wo ... | 2017 | 28618987 |
| molecular cloning and analysis of a c-type lectin from silkworm bombyx mori. | c-type lectins (ctls) play a variety of roles in plants and animals. they are involved in animal development, pathogen recognition, and the activation of immune responses. ctls carry one or more non-catalytic carbohydrate-recognition domains (crds) to bind specific carbohydrates reversibly. here, we report the molecular cloning and functional analysis of a single-crd ctl, named c-type lectin-s2 (bmctl-s2) from the domesticated silkmoth bombyx mori (lepidoptera: bombycidae). the orf of ctl-s2 is ... | 2017 | 28618068 |
| the structural assembly switch of cell division protein ftsz probed with fluorescent allosteric inhibitors. | ftsz is a widely conserved tubulin-like gtpase that directs bacterial cell division and a new target for antibiotic discovery. this protein assembly machine cooperatively polymerizes forming single-stranded filaments, by means of self-switching between inactive and actively associating monomer conformations. the structural switch mechanism was proposed to involve a movement of the c-terminal and n-terminal ftsz domains, opening a cleft between them, allosterically coupled to the formation of a t ... | 2017 | 28616148 |
| cytotoxic and antimicrobial activities of cantharellus cibarius fr. (cantarellaceae). | antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of cantharellus cibarius were tested. broth microdilution assay was performed against 10 bacterial strains (staphylococcus aureus, s. epidermidis, micrococcus luteus, bacillus subtilis, enterococcus feacalis, escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, salmonella abony), with emphasis on helicobacter pylori. methanol extract was the most active against h. pylori strains wit ... | 2017 | 28613963 |
| microcontact imprinted plasmonic nanosensors: powerful tools in the detection of salmonella paratyphi. | identification of pathogenic microorganisms by traditional methods is slow and cumbersome. therefore, the focus today is on developing new and quicker analytical methods. in this study, a surface plasmon resonance (spr) sensor with a microcontact imprinted sensor chip was developed for detecting salmonella paratyphi. for this purpose, the stamps of the target microorganism were prepared and then, microcontact s. paratyphi-imprinted spr chips were prepared with the functional monomer n-methacrylo ... | 2017 | 28608810 |
| enzyme inhibitory, antifungal, antibacterial and hemolytic potential of various fractions of colebrookia oppositifolia. | the purpose of the present investigation was to assess the enzyme inhibition, antifungal, antibacterial and hemolytic activities of various fractions of colebrookia oppositifolia smith. the meoh extract of plant was dissolved in dist. water and partitioned with n-hexane, chcl3, etoac and n-buoh sequentially. enzyme inhibition studies were done against four enzymes i.e. α-glucosidase, butyrylcholinesterase, acetyl cholinesterase and lipoxygenase. ethyl acetate fraction possessed very good activit ... | 2017 | 28603120 |
| a truncated sph12-38 with potent antimicrobial activity showing resistance against bacterial challenge in oryzias melastigma. | antimicrobial peptides (amps) represent an efficient part of innate immunity and are found in a variety of life. among them histone 2a (h2a), as a promising class of amps, attracts great attention, but the in vivo mechanism of h2a derived amp is still less known. based on the acquisition of sphistin, a synthetic 38-amino acid h2a derived peptide from scylla paramamosain, as reported in our previous study, was truncated into three short fragments (sph12-38, sph20-38 and sph30-38) and further inve ... | 2017 | 28600196 |
| antimicrobial effect of okcel® h-d prepared from oxidized cellulose. | the antimicrobial effect of okcel® h-d, a topical, absorbable hemostatic textile prepared from oxidized cellulose, was tested. testing by dilution and diffusion methods was conducted on a spectrum of 27 select microorganisms, including also antibiotic-resistant strains. okcel® h-d showed inhibitory effects on nearly all tested bacteria. in testing using the dilution suspension method, the majority of bacteria showed decrease in cell density by 7-8 orders of magnitude after just 6 h of exposure. ... | 2017 | 28597345 |
| antibacterial and anticancer activities of acetone extracts from in vitro cultured lichen-forming fungi. | lichens that were used in traditional medicine for ages produce numerous secondary metabolites, however our knowledge about biological activities of substances secreted by separated bionts is scarce. the main objectives of this study were to isolate and find optimal conditions for the growth of mycelia from three common lichen-forming fungi, i.e. caloplaca pusilla, protoparmeliopsis muralis and xanthoria parietina and to evaluate antibacterial and antiproliferative activities of their acetone ex ... | 2017 | 28592323 |
| investigation into the antimicrobial action and mechanism of a novel endogenous peptide β-casein 197 from human milk. | a novel endogenous peptide cleaved from 197-213 aa of β-casein, named β-casein 197, was identified by tandem mass spectrometry. β-casein 197 constituted a significant proportion of the peptide content in preterm milk. this study investigated the antibacterial effects and mechanisms against common pathogenic bacteria. six bacterial strains were selected for this study: escherichia coli, staphylococcus aureus, yersinia enterocolitica, listeria monocytogenes, klebsiella pneumonia and bacillus subti ... | 2017 | 28591979 |
| evaluation of phenolic profile and antibacterial bioactivities of nigella sativa l. seed extracts. | black cumin (nigella sativa l. [n. sativa]) seed extracts demonstrated numerous beneficial biological effects including, among others, antidiabetic, anticancer, immunomodulatory, antimicrobial, anti-inflammatory, antihypertensive, and antioxidant activity. to better understand the phytochemical composition of n. sativa seeds, methanol seed extracts were analyzed for phenolic acid and flavonoid content. furthermore, we tested n. sativa methanol, n-hexane, and aqueous seed extracts for their inhib ... | 2017 | 28590231 |
| production of macrolide antibiotics from a cytotoxic soil streptomyces sp. strain zdb. | crude extract from a culture of a soil streptomyces sp. strain zdb showed toxicity towards artemia salina and antimicrobial activity against escherichia coli, bacillus subtilis, staphylococcus aureus, chlorella vulgaris, and chlorella sorokiniana. large scale fermentation of the strain led to the isolation of the macrolide antibiotics, bafilomycins a1 (1), b1 (2), and d (3) together with nonactic acid (4) and bostrycoidin-9-methyl ether (5). structures of the antibiotics were determined based on ... | 2017 | 28585168 |
| in vitro antibacterial activity of poly (amidoamine)-g7 dendrimer. | nano-scale dendrimers are synthetic macromolecules that frequently used in medical and health field. traditional anibiotics are induce bacterial resistence so there is an urgent need for novel antibacterial drug invention. in the present study seventh generation poly (amidoamine) (pamam-g7) dendrimer was synthesized and its antibacterial activities were evaluated against representative gram- negative and gram-positive bacteria. | 2017 | 28583153 |
| antimicrobial peptide from bacillus subtilis csb138: characterization, killing kinetics, and synergistic potency. | we studied the prospect of synergy between the antimicrobial peptide p138c and non-peptide antibiotics for increasing the potency and bacterial killing kinetics of these agents. the production of p138c was maximized in the late exponential growth phase of bacillus subtilis csb138. purification of p138c resulted in a total of 4800 arbitrary units (au) with 19.15-fold and 3.2% recovery. peptide p138c was thermo-tolerant up to 50 °c and stable at ph 5.8 to 11. the biochemical nature of p138c was de ... | 2017 | 28581021 |
| new phenalenone derivatives from pinellia ternata tubers derived aspergillus sp. | nine new phenalenone derivatives (1-9), along with two known analogues (10-11) have been isolated from the solid cultures of an endophytic fungus aspergillus sp. which was obtained from pinellia ternate. their structures were established through interpretations of spectroscopic evidence, and some of their absolute configurations were determined by electronic circular dichroism (ecd) and mo2(ococh3)4 induced ecd. all of the phenalenones are unusual acyclic diterpenoid adducts, which are diversely ... | 2017 | 28577908 |
| antibacterial and antioxidant potential of stem bark extract of bombax ceiba collected locally from south punjab area of pakistan. | ethnic medication systems have been used extensively by humans since their origin. now a day, in the developing countries these systems are being used due to their effectiveness and affordability. especially inhabitants of rural areas still rely on these systems as first line of treatment against diseased conditions. till now, majority of medicines is derived from the natural origin particularly plants owing to their little side effects and cost effectiveness. | 2017 | 28573217 |
| new merosesquiterpenes from a vietnamese marine sponge of spongia sp. and their biological activities. | the investigation of the vietnamese marine sponge spongia sp. led to the isolation of three new sesquiterpene phenols, langconols a-c (1-3), and one new sesquiterpene hydroxyquinone, langcoquinone c (4), together with two known meroterpenoids (5 and 6). their structures were determined on the basis of spectroscopic analyses and comparisons with published data. furthermore, the antibacterial assays of the isolates 1-6 suggested that 4 and 6 had significant antibacterial activities against bacillu ... | 2017 | 28558970 |
| phenanthrenes from arundina graminifolia and in vitro evaluation of their antibacterial and anti-haemolytic properties. | chemical investigation and activity test of arundina graminifolia led to the isolation of six phenanthrenes: blestriarene a (1), shancidin (2), densiflorol b (3), ephemeranthoquinone (4), coelonin (5) and lusianthridin (6). the isolated compounds demonstrated antibacterial and anti-haemolytic activities. it was found that compounds 1 and 2 had medium antibacterial activity against staphylococcus aureus, bacillus subtilis and escherichia coli, with mics of 20-40 μg/ml and mbcs of 40-320 μg/ml. ba ... | 2017 | 28553728 |
| introducing a novel mushroom from mycophagy community with emphasis on biomedical potency. | mushrooms have been prized by humankind as medicine and culinary wonder since antiquity. though several species are ethnically valued; many prospective species are still being discovered. one such wild macrofungus has recently been discovered during subsequent field surveys in west bengal, india which in turn exposed as a traditionally consumed popular myco-food. the collected taxon was found to be unique with regard to its morphological as well as genetical features. after detailed characteriza ... | 2017 | 28552988 |
| 4-substituted thieno[2,3-d]pyrimidines as potent antibacterial agents: rational design, microwave-assisted synthesis, biological evaluation and molecular docking studies. | in an attempt to discover a new class of antibacterial agents with improved efficacy and to overcome the drug-resistant problems, some novel 4-substituted thieno[2,3-d]pyrimidines have been synthesized via microwave-assisted methodology and evaluated for their in vitro antibacterial activity against various pathogenic bacterial strains. compounds 12b and 13c showed the promising inhibitory potencies against staphylococcus aureus, bacillus subtilis, pseudomonas aeruginosa and escherichia coli wit ... | 2017 | 28544494 |
| obtaining titanium dioxide nanoparticles with spherical shape and antimicrobial properties using m. citrifolia leaves extract by hydrothermal method. | in this work, we synthesized titanium dioxide (tio2) nanoparticles using leaf extract of morinda citrifolia (m. citrifolia) by the advanced hydrothermal method. the synthesized tio2 nanoparticles were characterized by x-ray diffraction (xrd), fourier transmission infrared (ft-ir), ultraviolet-visible diffuse reflectance (uv-vis drs), ultraviolet-visible spectroscopy (uv-vis), raman spectroscopy, and scanning electron microscopy with energy dispersive x-ray spectroscopy (sem with edx) techniques. ... | 2017 | 28501689 |
| bacterial nucleoid occlusion: multiple mechanisms for preventing chromosome bisection during cell division. | in most bacteria cell division is driven by the prokaryotic tubulin homolog, ftsz, which forms the cytokinetic z ring. cell survival demands both the spatial and temporal accuracy of this process to ensure that equal progeny are produced with intact genomes. while mechanisms preventing septum formation at the cell poles have been known for decades, the means by which the bacterial nucleoid is spared from bisection during cell division, called nucleoid exclusion (no), have only recently been dedu ... | 2017 | 28500529 |
| synthesis, biological evaluation and molecular modeling study of new (1,2,4-triazole or 1,3,4-thiadiazole)-methylthio-derivatives of quinazolin-4(3h)-one as dhfr inhibitors. | a new series of 2-mercapto-quinazolin-4-one analogues was designed, synthesized and evaluated for their in vitro dhfr inhibition, antitumor and antimicrobial activity. compound 17 proved to be the most active dhfr inhibitor with ic50 value of 0.01μm, eight fold more active than methotrexate (mtx). compounds 16 and 24 showed antitumor activity against human caco2 colon and mcf-7 breast tumor cell lines with ic50 values of 25.4 and 9.5μg/ml, respectively. compounds 15, 20, 21 and 30 showed conside ... | 2017 | 28499189 |
| antibacterial activity of isolated immunodominant proteins of naja naja (oxiana) venom. | the aim of this study is to investigate antibacterial effects of immunodominant proteins isolated from the venom of naja naja oxiana snake against staphylococcus aureus, escherichia coli, bacillus subtilis and pseudomonas aeruginosa. the innate immune system is an important line of defense against bacterial diseases. antibacterial peptides and proteins produced by snake venoms have recently attracted significant attention due to their relevance to bacterial diseases and the potential of being co ... | 2017 | 28496483 |
| evaluation of pigments from methanolic extract of tagetes erecta and beta vulgaris as antioxidant and antibacterial agent. | the total phenolic content (tpc), antioxidant and antibacterial activities of methanolic extract of marigold flower (mf) (tagetes erecta) and beet root (br) (beta vulgaris) were examined. the present work reveals that mf contained greater amount of tpc (42.5 mg/g gae) as compared to br (39.4 mg/g gae). methanolic extract of mf exhibited excellent dpph free radical scavenging power (ic50 0.0716 mg/ml) and reducing power at 1 mg/ml concentration. similar results have been obtained in ftc and tba m ... | 2017 | 28494614 |
| isolation and characterization of chemical constituents from chrysophyllum albidum g. don-holl. stem-bark extracts and their antioxidant and antibacterial properties. | the plant, chrysophyllum albidum is indigenous to nigeria and its stem-bark has wide application in traditional medicine for the treatment of infections and oxidative stress related diseases. the aim of the study was to isolate the chemical constituents responsible for the antioxidant and antibacterial activity from the stem-bark of the plant in order to justify some of its ethnomedicinal uses. | 2016 | 28487910 |
| saccharomyces cerevisiae from brazilian kefir-fermented milk: an in vitro evaluation of probiotic properties. | the therapeutic use of probiotics for supporting the antibiotic action against gastrointestinal disorders is a current trend and emerging applications have gained popularity because of their support for various microbiological activities in digestive processes. microorganisms isolated from kefir with great probiotic properties, in addition to high resistance to harsh environmental conditions, have been widely researched. administration of probiotic yeasts offers a number of advantages, when comp ... | 2017 | 28478200 |
| plipastatin and surfactin coproduction by bacillus subtilis pb2-l and their effects on microorganisms. | to convert the lipopeptide non-producer strain bacillus subtilis pb2 into a plipastatin and surfactin coproducer, a gene expression cassette composed of a constitutive promoter (p43), functional gene sfp, and pleiotropic regulatory gene degq was integrated into the chromosomal amye locus of strain b. subtilis pb2 by homologous recombination, which generated a plipastatin and surfactin co-producer. thirteen plipastatins and fifteen surfactins were identified in lipopeptide extracts using analytic ... | 2017 | 28477175 |
| green synthesis of silver nanoparticles from grape and tomato juices and evaluation of biological activities. | the biosynthesis of silver nanoparticles (agnps) is substantial for its application in lots of fields. tomato and grape fruit juices were used as a reducing and capping agents for the biosynthesis of agnps. ultraviolet spectroscopic analysis offered peaks in the range of 396‒420 nm that indicate the production of agnps. fourier transform infrared spectroscopy analysis revealed attachment of different functional groups with ag ion in both tomato and grape fruit extracts nps. the x‒ray diffraction ... | 2017 | 28477003 |
| actinobacterial-mediated synthesis of silver nanoparticles and their activity against pathogenic bacteria. | in this study, silver nanoparticles (agnps) were biosynthesised by using acidophilic actinobacterial sh11 strain isolated from pine forest soil. isolate sh11 was identified based on 16s rrna gene sequence to streptomyces kasugaensis m338-m1(t) and s. celluloflavus nrrl b-2493(t) (99.8% similarity, both). biosynthesised agnps were analysed by uv-visible spectroscopy, which revealed specific peak at λ = 420 nm. transmission electron microscopy analyses showed polydispersed, spherical nanoparticles ... | 2017 | 28476992 |
| synthesis and characterization of mwcnt/tio2/au nanocomposite for photocatalytic and antimicrobial activity. | a novel combination of titanium oxide (tio2)/gold (au)/multiwalled carbon nanotubes (mwcnts) nanocomposite (nc) was synthesised by sol- gel method. mwcnt functionalisation by modified hummers method. tio2/au nanoparticles (nps) were synthesised by biological method using terminalia chebula bark extract. mwcnt/tio2/au nc samples were characterised by x-ray diffraction, ultraviolet-visible-diffuse reflectance spectra, microraman, scanning electron microscopy and high-resolution-transmission electr ... | 2017 | 28476971 |
| mitochondria-targeted antioxidants as highly effective antibiotics. | mitochondria-targeted antioxidants are known to alleviate mitochondrial oxidative damage that is associated with a variety of diseases. here, we showed that skq1, a decyltriphenyl phosphonium cation conjugated to a quinone moiety, exhibited strong antibacterial activity towards gram-positive bacillus subtilis, mycobacterium sp. and staphylococcus aureus and gram-negative photobacterium phosphoreum and rhodobacter sphaeroides in submicromolar and micromolar concentrations. skq1 exhibited less ant ... | 2017 | 28469140 |
| silver nanoparticles mediated by costus afer leaf extract: synthesis, antibacterial, antioxidant and electrochemical properties. | synthesis of metallic and semiconductor nanoparticles through physical and chemical routes has been extensively reported. however, green synthesized metal nanoparticles are currently in the limelight due to the simplicity, cost-effectiveness and eco-friendliness of their synthesis. this study explored the use of aqueous leaf extract of costus afer in the synthesis of silver nanoparticles (ca-agnps). the optical and structural properties of the resulting silver nanoparticles were studied using uv ... | 2017 | 28468278 |
| a conserved regulatory mechanism in bifunctional biotin protein ligases. | class ii bifunctional biotin protein ligases (bira), which catalyze post-translational biotinylation and repress transcription initiation, are broadly distributed in eubacteria and archaea. however, it is unclear if these proteins all share the same molecular mechanism of transcription regulation. in escherichia coli the corepressor biotinoyl-5'-amp (bio-5'-amp), which is also the intermediate in biotin transfer, promotes operator binding and resulting transcription repression by enhancing bira ... | 2017 | 28466579 |
| dna interaction, antimicrobial, anticancer activities and molecular docking study of some new vo(ii), cr(iii), mn(ii) and ni(ii) mononuclear chelates encompassing quaridentate imine ligand. | the present study was conducted to synthesis of some new imine cr(iii), vo(ii), mn(ii) and ni(ii) complexes derived from the condensation of 2-amino phenol with 2-hydroxynapthaldehyde were synthesized. the prepared hnpn imine ligand was analyzed by its melting point, ir, (1)h nmr and (13)c nmr spectroscopies. the investigated hnpn imine complexes were characterized by elemental analysis, ft ir, uv-vis and thermal analysis (tga) under nitrogen atmosphere from ambient temperature to 750°c. the exp ... | 2017 | 28456118 |
| newly identified invertebrate-type lysozyme (splys-i) in mud crab (scylla paramamosain) exhibiting muramidase-deficient antimicrobial activity. | lysozymes are widely distributed immune effectors exerting muramidase activity against the peptidoglycan of the bacterial cell wall to trigger cell lysis. however, some invertebrate-type (i-type) lysozymes deficient of muramidase activity still exhibit antimicrobial activity. to date, the mechanism underlying the antimicrobial effect of muramidase-deficient i-type lysozymes remains unclear. accordingly, this study characterized a novel i-type lysozyme, splys-i, in the mud crab scylla paramamosai ... | 2017 | 28438599 |
| synthesis, antioxidant and antimicrobial activities of novel thiopyrano[2,3-d]thiazoles based on aroylacrylic acids. | here it is described the synthesis, antioxidant and antimicrobial activity determination of novel rel-([formula: see text])-6-benzoyl-7-phenyl-2-oxo-3,5,6,7-tetrahydro-2h-thiopyrano[2,3-d]thiazole-5-carboxylic acids. the target compounds were obtained in good yields from 5-arylidene-4-thioxo-2-thiazolidinones and [formula: see text]-aroylacrylic acids via regio- and diastereoselective hetero-diels-alder reaction. the stereochemistry of the cycloaddition was confirmed by nmr spectra. the antioxid ... | 2017 | 28424934 |
| gc-ms based metabolite profiling, antioxidant and antimicrobial properties of different solvent extracts of malaysian plectranthus amboinicus leaves. | this study evaluates the phytochemistry, antioxidant, and antimicrobial effects of plectranthus amboinicus leaves extracted in different solvents. the methanol extract contained the highest total phenolic (94.37 ± 1.24 mg gae/g) and flavonoid contents (26.90 ± 1.35 mg re/g) and exhibited the highest dpph scavenging activity (90.13 ± 3.32%) followed by the acetone extract (80.23 ± 3.26%) at 500 μg/ml concentration. similarly, the highest ferric ion reduction potential (849.63 ± 30.95 μm of fe (ii ... | 2017 | 28424737 |
| molecular profiling and bioactive potential of an endophytic fungus aspergillus sulphureus isolated from sida acuta: a medicinal plant. | sida acuta burm.f. (malvaceae) extracts are reported to have applications against malaria, diuretic, antipyretic, nervous and urinary diseases. no fungal endophytes of s. acuta are reported. | 2017 | 28424024 |
| syntheses of benzophenone-xanthone hybrid polyketides and their antibacterial activities. | muchimangins are benzophenone-xanthone hybrid polyketides produced by securidaca longepedunculata. however, their biological activities have not been fully investigated, since they are minor constituents in this plant. to evaluate the possibility of muchimangins as antibacterial agent candidates, five muchimangin analogs were synthesized from 2,4,5-trimethoxydiphenyl methanol and the corresponding xanthones, by utilizing p-toluenesulfonic acid monohydrate for the brønsted acid-catalysis. the ant ... | 2017 | 28416134 |
| phytosynthesis of silver nanoparticles using aqueous leaf extracts of lippia citriodora: antimicrobial, larvicidal and photocatalytic evaluations. | nanoscience and nanotechnology represent new and enabling platforms that promise to provide broad range of novel and improved technologies for environmental, biological and other scientific applications. this study reports the synthesis of silver nanoparticles mediated by aqueous leaf extract of lippia citriodora at two different temperatures of 50°c and 90°c. the synthesis of colloidal silver nanoparticles (agnps) was monitored by the use of uv-visible spectroscopy at different temperatures and ... | 2017 | 28415554 |
| effect of variable aminoalkyl chains on chemical grafting of cellulose nanofiber and their antimicrobial activity. | recent focus on the preparation of antimicrobial surfaces using cellulose nanofibers (cnf) has gained considerable attention. in this work, functionalization of cnf films in 100% aqueous solution with three different aminosilanes, including 3-aminopropyl trimethoxysilane (apms), 2-aminoethyl 3-aminopropyl trimethoxysilane (dams)and 3-2-(2-aminoethylamino) ethylamino propyl-trimethoxysilane (tams) is reported for the fabrication of contact active antimicrobial materials. grafted cnf films were co ... | 2017 | 28415526 |
| instant green synthesis of silver-based herbo-metallic colloidal nanosuspension in terminalia bellirica fruit aqueous extract for catalytic and antibacterial applications. | in the present study, microwave-assisted, optimized, instant, terminalia bellirica fruit extract-mediated green synthesis of colloidal silver nanoparticles (agnps) has been reported. the synthesized agnps were characterized by uv-vis spectroscopy, ftir, zetasizer, fesem, edx and xrd. the characteristic surface plasmon peak of reaction mixture at 406 nm confirmed the synthesis of agnps. the ftir studies confirmed phytoconstituents were responsible for the synthesis and stability of agnps. the fes ... | 2017 | 28409425 |
| silver/chitosan-based janus particles: synthesis, characterization, and assessment of antimicrobial activity in vivo and vitro. | janus particles containing chitosan and silver were synthesized in an eco-friendly manner and were confirmed using transmission electron microscopy. based on the data of the antimicrobial activity assessment, this material exhibited a higher antimicrobial activity than virgin chitosan with long-lasting antibacterial effectiveness against staphylococcus aureus, bacillus subtilis, escherichia coli and salmonella choleraesuis bacteria, as well as botrytis cinerea fungi. the results showed that the ... | 2015 | 28433312 |
| metabolite profiling, antioxidant and antibacterial activities of brazilian propolis: use of correlation and multivariate analyses to identify potential bioactive compounds. | the production of propolis by honeybees results from a selective collection of exudates from various plant species and present many potentialities in the pharmaceutical industry. the objective of this study was to investigate the chemical profile of brazilian propolis, as well as their in vitro antioxidant and antibacterial activities. gas chromatography-mass spectrometry was applied for chemical profiling of propolis extracts. total phenolic compounds were quantified by folin-ciocalteu and anti ... | 2015 | 28455025 |
| isolation and partial purification of erythromycin from alkaliphilic streptomyces werraensis isolated from rajkot, india. | an alkaliphilic actinomycete, bci-1, was isolated from soil samples collected from saurashtra university campus, gujarat. isolated strain was identified as streptomyces werraensis based on morphological, biochemical and phylogenetic analysis. maximum antibiotic production was obtained in media containing sucrose 2%, yeast extract 1.5%, and nacl 2.5% at ph 9.0 for 7 days at 30 °c. maximum inhibitory compound was produced at ph 9 and at 30 °c. ftir revealed imine, amine, alkane (c 000000000000 000 ... | 2014 | 28435796 |
| a proteomic signature of dormancy in the actinobacterium micrococcus luteus. | dormancy is a protective state in which diverse bacteria, including mycobacterium tuberculosis, staphylococcus aureus, treponema pallidum (syphilis), and borrelia burgdorferi (lyme disease), curtail metabolic activity to survive external stresses, including antibiotics. evidence suggests dormancy consists of a continuum of interrelated states, including viable but nonculturable (vbnc) and persistence states. vbnc and persistence contribute to antibiotic tolerance, reemergence from latent infecti ... | 2017 | 28484042 |
| structural and biochemical analyses indicate that a bacterial persulfide dioxygenase-rhodanese fusion protein functions in sulfur assimilation. | hydrogen sulfide (h2s) is a signaling molecule that is toxic at elevated concentrations. in eukaryotes, it is cleared via a mitochondrial sulfide oxidation pathway, which comprises sulfide quinone oxidoreductase, persulfide dioxygenase (pdo), rhodanese, and sulfite oxidase and converts h2s to thiosulfate and sulfate. natural fusions between the non-heme iron containing pdo and rhodanese, a thiol sulfurtransferase, exist in some bacteria. however, little is known about the role of the pdo-rhodane ... | 2017 | 28684420 |
| pre-banking microbial contamination of donor conjunctiva and storage medium for penetrating keratoplasty. | the aims of this study were to investigate the incidence of positive donor tissue cultures before transfer to preservation medium (optisol™-gs) for penetrating keratoplasty, to verify the efficacy of antibiotics contained in optisol™-gs by examining the drug susceptibility and to assess the relationship between the results of our microbial assessments as well as donor factors and the incidence of contamination. | 2017 | 28597192 |