| tympanostomy tubes and water exposure: a practical model. | to determine whether water exposure causes middle ear contamination in patients with collar button tympanostomy tubes (tts). | 1998 | 9776190 |
| [experimental studies of the protective effect of deferoxamine mesilate on cisplatin induced toxicity]. | cisplatin (cddp) is an antitumor agent against several types of neoplasms. it has, however, various side effects such as nephrotoxicity and ototoxicity. several efforts have been made to prevent these toxic side effects. on the other hand, deferoxiamine mesilate (dfo), an iron-chelating agent, has been used for iron-overloaded patients. since the 1980s, many authors have reported dfo-associated hearing impairment. some experimental data suggest that dfo itself was responsible for ototoxicity. in ... | 1998 | 9778942 |
| characterization of rat pancreatic glutathione s-transferases by chromatofocusing, reverse-phase high-performance liquid chromatography, and immunohistochemistry. | the cytosolic glutathione s-transferases (gsts) are a family of phase ii detoxifying isoenzymes that catalyze the interaction of the tripeptide thiol glutathione (gsh) with a wide variety of reactive and often toxic or carcinogenic electrophilic substrates. pancreatic gsts, however, have only been partially characterized. in this study, pancreatic cytosolic gsts from male fisher 344 rats were semipurified by affinity chromatography and then analyzed for isoenzyme content by chromatofocusing (fas ... | 1998 | 9788534 |
| psychomotor and spatial memory performance in aging male fischer 344 rats. | psychomotor and spatial memory performance were examined in male fischer 344 rats that were 6, 12, 15, 18, and 22 months of age, to assess these parameters as a function of age and to determine at what age these behaviors begin to deteriorate. complex motor behaviors, as measured by rod walk, wire suspension, plank walk, inclined screen, and accelerating rotarod performance, declined steadily with age, with most measures being adversely affected as early as 12 to 15 months of age. spatial learni ... | 1998 | 9789738 |
| antibiotic susceptibility in the surgical intensive care unit compared with the hospital-wide antibiogram. | to compare the antibiotic susceptibility of bacterial isolates from patients in the surgical intensive care unit (sicu) with hospital-wide bacterial susceptibility. | 1998 | 9790198 |
| diversification of response to hsp65 during the course of autoimmune arthritis is regulatory rather than pathogenic. | determinant spreading has been implicated in the pathogenesis of certain autoimmune diseases in animal models. we have observed that during the course of adjuvant arthritis (aa) in the lewis rat, there is 'diversification' of response to the bacterial 65-kda heat shock protein (bhsp65) towards its carboxy-terminal determinants (bctd). strikingly, pretreatment of naive lewis rats with bctd affords significant protection from aa. our preliminary studies indicate that the diversification of respons ... | 1998 | 9795775 |
| role of medullasin in nifedipine-induced gingival overgrowth in rats. | to clarify the possible pathophysiological role of medullasin, a neutrophil elastase-like proteinase, in nifedipine (nf)-induced gingival overgrowth, a rat model of gingival overgrowth was first established using a diet containing nf. the relation between histopathological changes and the distribution of the proteinase was then investigated. thirty-two, specific pathogen-free 20 day-old, male, fisher 344 rats were fed a diet containing nf and killed at 2, 8, 16 and 32 weeks. control rats (n = 32 ... | 1998 | 9796781 |
| serological diagnosis of respiratory viral infections. a five-year study of hospitalised patients. | the results of a five-year study of paired sera from 410 hospitalised patients-mainly children-with respiratory illness are reported. samples were divided into groups based on clinical diagnosis. the data of each group were analysed in relation to patient age (under or over 1 year of age). the percentage of positive serological diagnoses ranged from 29.4% in the respiratory viral illness group to 46.2% in the bronchiolitis group. each group showed a prevalent serological diagnosis. respiratory v ... | 1998 | 9812318 |
| the role of y-encoded genes in mammalian spermatogenesis. | as long ago as 1931 fisher outlined the reasons for the accumulation of male 'benefit genes' (e.g. male fertility factors) on the y chromosome, but it was over four decades later that a study of men with partial y chromosome deletions revealed that a factor essential for male fertility was present on the human y. today, the y deletion interval containing this 'azoospermia factor' (azf) has been subdivided into three subintervals associated with different degrees of spermatogenic impairment. furt ... | 1998 | 9813189 |
| formation of nitric oxide by rat and hamster alveolar macrophages: an interstrain and interspecies comparison. | nitric oxide (no) plays an important role in non-specific host defense, which can be recognized by its antimicrobial and cytotoxic activity against pathogens. however, there appear to exist interspecies differences in the ability of macrophages to generate no. the object of this study was to determine whether there exist intraspecies differences in the production of no. we compared no formation by alveolar macrophages (am) from five different rat strains (sprague dawley, wistar, lewis, fisher, a ... | 1998 | 9820647 |
| human immunoglobulin preparations for intravenous use prevent endotoxin-induced uveitis in rats. | we analyzed the preventive effect of immunoglobulins for intravenous use (ivigs) in endotoxin-induced uveitis (eiu), a disease related to tumor necrosis factor alpha (tnf-alpha) production. | 1999 | 9831824 |
| relationship between maternal group b streptococcal colonization and pregnancy outcome. | to examine the association of maternal colonization with group b streptococcus (gbs) with preterm labor and premature rupture of the membranes (prom). | 1998 | 9840551 |
| interaction of exercise training and chronic ethanol ingestion on testicular antioxidant system in rat. | recent evidence has indicated that exercise as well as ethanol exerts oxidative stress on vital organs/tissues of the body. however, the combination of both on the testicular antioxidant system is not known. this study investigates the interactive effects of exercise training and chronic ethanol ingestion on the testicular antioxidant system in rats. male fisher-344 rats were treated as follows: sedentary control (sc); exercise training (et) for 6.5 weeks; ethanol (2 g kg(-1), p.o.) for 6.5 week ... | 1998 | 9840749 |
| spinal cord neural anatomy in rats examined by in vivo magnetic resonance microscopy. | magnetic resonance microscopy (mrm) is a technique that is worthwhile for anesthesiologists because it allows spinal cord and plexus anatomy to be visualized three dimensionally and followed over time in the same animal. for example, the long-term effect of indwelling intrathecal or plexus catheters can be studied in situ, and convective and diffusive forces within intrathecal, epidural, or nerve sheath spaces can be investigated. further, diffusion-weighted mrm, which measures an "apparent diff ... | 1998 | 9840856 |
| the sodium iodide symporter gene and its regulation by cytokines found in autoimmunity. | iodide concentration by the thyroid gland, an essential step for thyroid hormone synthesis, is mediated by the na+/i- symporter (nis). to identify factors that may regulate this process, we have studied nis gene expression in the fisher rat thyroid cell line (frtl-5) by a semi-quantitative reverse transcription-polymerase chain reaction (rt-pcr) technique. increasing concentrations of bovine tsh (0.1, 1, 10, 50 and 100 mu/l), with or without tumour necrosis factor-alpha (tnf alpha), interferon-g ... | 1998 | 9846164 |
| tissue distribution of dna adducts in male fischer rats exposed to 500 ppm of propylene oxide: quantitative analysis of 7-(2-hydroxypropyl)guanine by 32p-postlabelling. | 7-(2-hydroxypropyl)guanine (7-hpg) constitutes the major adduct from alkylation of dna by the genotoxic carcinogen, propylene oxide. the levels of 7-hpg in dna of various organs provides a relevant measure of tissue dose. 7-alkylguanines can induce mutation through abasic sites formed from spontaneous depurination of the adduct. in the current study the formation of 7-hpg was investigated in male fisher 344 rats exposed to 500 ppm of propylene oxide by inhalation for 6 h/day, 5 days/week, for up ... | 1998 | 9851292 |
| diastolic dysfunction coincides with early mild transplant rejection: in situ measurements in a heterotopic rat heart transplant model. | diastolic dysfunction seen in early clinical transplant rejection has been difficult to demonstrate in experimental rodent models because of the inability to make sensitive in situ measurements of systolic and diastolic functions. we have developed a heterotopic heart transplant model with fisher 344 and aci rats (without immunosuppression), where in situ measurements of diastolic and systolic functions were made sequentially (daily) by use of an implanted left ventricular balloon. | 1998 | 9855443 |
| morphological variability in fasciola hepatica eggs in ruminants, rodents and lagomorphs. | the length and width of 1297 fasciola hepatica eggs shed in cattle hosts, 337 in sheep and 199 in nutria, were measured from several parts of france. the data were compared with those obtained from other studies in spain, france (where rats were also investigated), germany and the netherlands. one way analysis of variance and discriminant analysis were used to assess differences between host origins. the distribution of length and width of eggs were analysed using skewness and kurtosis fisher co ... | 1998 | 9858627 |
| coulombic effects of remote subsites on the active site of ribonuclease a. | the active-site cleft of bovine pancreatic ribonuclease a (rnase a) is lined with cationic residues that interact with a bound nucleic acid. those residues interacting with the phosphoryl groups comprise the p0, p1, and p2 subsites, with the scissile p-o5' bond residing in the p1 subsite. coulombic interactions between the p0 and p2 subsites and phosphoryl groups of the substrate were characterized previously [fisher, b. m., ha, j.-h., and raines, r. t. (1998) biochemistry 37, 12121-12132]. here ... | 1998 | 9860854 |
| loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development. | germline defects in the tuberous sclerosis 2 (tsc2) tumor suppressor gene predispose humans and rats to benign and malignant lesions in a variety of tissues. the brain is among the most profoundly affected organs in tuberous sclerosis (tsc) patients and is the site of development of the cortical tubers for which the hereditary syndrome is named. a spontaneous germline inactivation of the tsc2 locus has been described in an animal model, the eker rat. we report that the homozygous state of this m ... | 1998 | 9861021 |
| the role of vitamin e in t-cell differentiation and the decrease of cellular immunity with aging. | spontaneously hypertensive rats (shr) as a model for aging were used in this experiment and fed a regular (50 iu/kg diet) or high vitamin e (500 iu/kg diet) diet for 6 weeks. at 12 weeks old, they were killed and assayed. although proliferation of thymic lymphocytes was significantly decreased in shr fed the regular diet compared to wistar kyoto rats (wky) fed the same diet, high vitamin e diet enhanced proliferation of thymic lymphocytes in shr to almost the levels in wky fed the regular diet. ... | 1998 | 9864960 |
| effects of n-acetylcysteine and 2,3-dimercaptosuccinic acid on lead induced oxidative stress in rat lenses. | lead (pb) is known to disrupt the pro-oxidant/anti-oxidant balance of tissues which leads to biochemical and physiological dysfunction. the present study investigated the effects of exposure on the redox status of the lenses of fisher 344 rats and examined whether antioxidant or chelator administration reversed these changes. animals were given 5 weeks of 2000 ppm pb exposure followed by 1 week of either antioxidant, chelator or distilled water administration. glutathione (gsh) and cysteine (cys ... | 1998 | 9865483 |
| effect of a topically applied neutralizing antibody against vascular endothelial growth factor on corneal allograft rejection of rat. | studies in corneal transplant rejection remain important because acute immunologic rejection continues to be the leading cause of human corneal transplant failure. as the permeability of vessels and the neovascularization induce cells infiltration into the graft, we considered the possibility that vascular endothelial growth factor (vegf), a potent permeability-increasing factor and angiogenesis-mediating factor, could participate in the immune response. | 1998 | 9869094 |
| mixed hematopoietic chimerism induces donor-specific tolerance for lung allografts in rodents. | mixed hematopoietic chimerism is a state in which bone marrow hematopoietic stem cells from two genetically different animals coexist. we investigated whether mixed hematopoietic chimerism, resulting from the transplantation of host and donor bone marrow into a lethally irradiated rat, would confer donor-specific tolerance to lung allografts. recipient rats (fisher or or wistar furth [wf]) were irradiated (1,100 cgy) and reconstituted with a mixture of t-cell-depleted syngeneic plus allogeneic b ... | 1999 | 9872839 |
| unopposed neutrophil elastase in bronchoalveolar lavage from transplant recipients with cystic fibrosis. | large numbers of neutrophils with unopposed neutrophil elastase (ne) proteolytic activity are found in lower respiratory tract secretions from most patients with advanced cystic fibrosis (cf). to determine whether antielastase defenses may be overwhelmed in epithelial lining fluid after lung transplantation, we measured ne activity (cleavage of the specific substrate, meo-suc-ala-ala-pro-val-pna) in bronchoalveolar lavage fluids (balf) obtained for surveillance or diagnostic purposes at various ... | 1999 | 9872847 |
| identification of highly fucosylated n-linked oligosaccharides from the human parotid gland. | the glycosylation of a number of constituents of human saliva is known to modify its biological roles, such as its lubricating properties and binding of microbial flora. gillece-castro et al. [gillece-castro, b. l., prakobphol, a., burlingame, a. l., leffler, h. & fisher, s. j. (1991) j. biol. chem. 266, 17358-17368] have proposed that the major glycan on the salivary proline-rich glycoproteins is a trifucosylated biantennary sugar with one difucosylated and one unfucosylated antenna. furthermor ... | 1998 | 9874230 |
| k-ras gene point mutations in human endometrial carcinomas: correlation with clinicopathological features and patients' outcome. | in order to evaluate the role of k-ras gene point mutations in the progression of endometrial carcinoma, we applied the polymerase chain reaction/restriction-fragment-length polymorphism technique to 57 tumours surgically removed from women of polish origin. we assessed the relationship between k-ras gene activation and clinicopathological features as well as patients' outcome. mutational activation in codon 12 of the k-ras gene was detected in 8 out of 57 (14%) endometrial carcinomas, while in ... | 1998 | 9879831 |
| wax d of mycobacterium tuberculosis induced osteomyelitis accompanied by reactive bone formation in buffalo rats. | a suspension of heat-killed mycobacterium tuberculosis in liquid paraffin has been reported to induce foot swelling accompanied by new bone formation in buffalo (buf) rats, which are low responders to the induction of adjuvant arthritis. in the present study, we found that wax d, a mycobacterial cell wall peptidoglycan fragment-arabinogalactan-mycolic acid complex, was an effective component of this bacterium for the induction of osteomyelitis accompanied by reactive bone formation in buf rats. ... | 1998 | 9879920 |
| age-related decrease in brain synaptic membrane ca2+-atpase in f344/bnf1 rats. | we used fisher 344/brown norway hybrid rats (f344/bnf1) to determine whether previously reported decreases in brain synaptic plasma membrane (spm) ca2+-atpase activity in inbred f344 rats also occurred in the hybrids. plasma membrane ca2+-atpase (pmca) activity in spms from f344/bnf1 rat brains showed a progressive age-dependent decrease in vmax from 60.9 +/- 3.7 nmol pi/mg/min (n = 6) in 5-month rats to 32.4 +/- 3.6 nmol pi/mg/min (n = 6) in 34-month animals, with no change in k (act) for ca2+. ... | 1998 | 9880051 |
| [influence of pregnancy in chronic hepatitis c virus infection]. | there is scarce information about the influence of pregnancy in patients with chronic hepatitis c virus infection is little know. | 1998 | 9881344 |
| [maternal viral and gestational risk factors in vertical transmission of hiv-1 infection]. | several risk factors are related to vertical transfer of hiv-1 infection, but the influence of each one separately is controversial. various risk factors have been evaluated altogether and separately, in order to find a single condition, that is, early in pregnancy predictive of fetal infection. | 1998 | 9882983 |
| usefulness of hybrid capture hpv dna assay as a diagnostic tool for human papillomavirus infection. | the purpose of this study was to determine the usefulness of the hybrid capture hpv dna assay, a new nonradioactive solution hybridization assay, as a diagnostic tool for human papillomavirus infection. in a total of 234 women, samples for the hybrid capture assay and polymerase chain reaction (pcr) assay were obtained by wiping a swab across the cervix and external os (either a dacron swab or a cotton swab was used). the papanicolaou smear test (pap smear) was carried out on all 234 women. tiss ... | 1998 | 9884509 |
| nitric oxide/cyclic guanosine monophosphate pathway in the peripheral and central auditory system of the rat. | the neuronal isoform of nitric oxide synthase (nnos) and soluble guanylate cyclase (sgc) were localized in the cochlea, the cochlear nucleus (cn), and the superior olivary complex (soc) of fisher 344 rats. in the cochlea, nnos was identified in spiral ganglion cells by using nicotinamide adenine dinucleotide phosphate (nadph)-diaphorase histochemistry and in situ hybridization. nadph-diaphorase staining also was detected in blood vessels of the modiolus. by using immunohistochemistry against cyc ... | 1999 | 9886024 |
| enhanced brain tumor selectivity of cationic magnetic polysaccharide microspheres. | a novel cationic delivery system composed of magnetic aminodextran microspheres (madm) 1-2 microm in diameter was evaluated along with neutral magnetic dextran microspheres (mdm) for their ability to target intracerebral rat glioma-2 (rg-2) tumors in vivo. the tissue distribution of the microspheres was determined following intraarterial injection (25 mg/kg) over 2 min in male fisher 344 rats bearing rg-2 tumors as well as normal animals with a magnetic field of 0 or 0.6 t applied to the brain f ... | 1998 | 9888308 |
| smooth muscle myosin. amino acid residues responsible for the hydrolysis of atp. | from their crystallographic comparisons, fisher et al. (biochemistry 34, 8960-8972, 1995) have proposed that in an important transition of myosin heads (m), m.atp-->m.adp.pi, an interdomain rotation occurs in gly468 (of chicken smooth muscle myosin) and that the rotated state is stabilized by newly-formed interdomain contacts including the salt link between glu470 and arg247 (of chicken smooth muscle myosin). here, we have studied the effects of gly468, glu470, and arg247 mutations on the hydrol ... | 1998 | 9889819 |
| campylobacter jejuni infection and guillain-barré syndrome: a case-control study. emilia-romagna study group on clinical and epidemiological problems in neurology. | we performed a case-control study to investigate the association between campylobacter jejuni (cj) infection and guillain-barr| syndrome (gbs) or miller-fisher syndrome. we compared 60 cases with 109 hospital controls matched for age, gender, hospital and geographical location. to diagnose the cj infection, we considered the association between serologic positivity for cj and a previous diarrheal illness within 3 months of inclusion in the study. fifteen percent of cases versus 5% of hospital co ... | 1998 | 9890808 |
| [remission ratio of chronic urticaria--"spontaneous" healing or result of eradication of helicobacter pylori?]. | helicobacter pylori infection has been assumed to be the underlying cause of some dermatological diseases such as, chronic urticaria. in order to investigate this problem we interviewed 55 patients with chronic urticaria concerning the state of the disease approximately 10 months after being discharged from hospital. after an additional six months we interviewed them for a second time and thus determined the remission ratio. there was no significant evidence showing that a link exists between ur ... | 1998 | 9914888 |
| clinical relevance of the determination of anti-gq1b antibodies in miller fisher and guillain-barré syndromes. | anti-gq1b antibodies were assayed by an enzyme-linked immunosorbent assay in sera from patients with non-neurological disorders (n = 20), and with various neurological disorders (n = 59), including nine cases of miller fisher syndrome, 16 cases of guillain-barré syndrome and one case of acute post-infectious ophthalmoparesis. such antibodies were found in most cases (8 out of 9) of miller fisher syndrome, and at very high titres, in one case of guillain-barré syndrome characterised by an initial ... | 1998 | 9922819 |
| synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia. | basic fibroblast growth factor (bfgf) and citicoline (cytidine 5'-diphosphate choline, an endogenous compound that stabilizes membrane function) have demonstrated neuroprotective effects after focal cerebral ischemia. both agents are candidates for future stroke therapy in humans. for evaluation of synergistic effects of bfgf and citicoline, a low-dose combination of both compounds was tested against each compound alone and placebo. | 1999 | 9933283 |
| comparison of recombinant human pth(1-34) (ly333334) with a c-terminally substituted analog of human pth-related protein(1-34) (rs-66271): in vitro activity and in vivo pharmacological effects in rats. | parathyroid hormone (pth) and pth-related protein (pthrp) are believed to exert their biological actions through binding and activation of a common cell surface receptor. recently, an analog of pthrp (rs-66271), was described that demonstrated reduced binding affinity for the pth/pthrp receptor compared with bovine pth(1-34) but retained equal biological activity. the present study investigated the receptor binding affinities of synthetic rs-66271 and recombinant human pth(1-34) (ly333334) and c ... | 1999 | 9933468 |
| [testicular lymphoma in two patients with aids and two without aids]. | to describe the clinical, morphological and inmunophenotypic characteristics and followup of testicular non hodgkin lymphomas seen in a referral center. | 1998 | 9949674 |
| smokeless tobacco cessation intervention for college athletes: results after 1 year. | the purpose of this study was to determine the efficacy of a college-based smokeless tobacco cessation intervention targeting college athletes. | 1999 | 9949754 |
| sensation recovery on innervated radial forearm flap for hemiglossectomy reconstruction by using different recipient nerves. | the objectives of this study were (1) to determine the extent of sensory recovery on hemitongues reconstructed with innervated radial forearm flaps and (2) to assess the influence of various clinical and surgical factors over the return of sensation, including the use of different recipient nerves for neurorrhaphy. twenty-eight patients with tongue cancer who underwent hemiglossectomy and primary reconstruction with innervated radial forearm flaps over a 3-year period were studied. mean postoper ... | 1999 | 9950530 |
| sustained microgravity reduces intrinsic wound healing and growth factor responses in the rat. | spaceflight is known to diminish bone mass and reduce immune function, suggesting that repair of connective tissue might be impaired in a microgravity environment. fisher 344 rats were used to test wound healing responses in the orbiting space shuttle endeavour by preflight implantation of polyvinyl acetal sponge disks in which pellets were placed to release either platelet-derived growth factor (pdgf-bb), basic fibroblast growth factor (bfgf), or placebo. control groups on the ground included a ... | 1999 | 9973320 |
| miller fisher anti-gq1b antibodies: alpha-latrotoxin-like effects on motor end plates. | in the miller fisher syndrome (mfs) variant of the guillain-barré syndrome, weakness is restricted to extraocular muscles and occasionally other craniobulbar muscles. most mfs patients have serum antibodies against ganglioside type gq1b of which the pathophysiological relevance is unclear. we examined the in vitro effects of mfs sera, mfs igg, and a human monoclonal anti-gq1b igm antibody on mouse neuromuscular junctions (nmjs). it was found that anti-gq1b antibodies bind at nmjs where they indu ... | 1999 | 9989621 |
| synthesis and evaluation of [18f]1-amino-3-fluorocyclobutane-1-carboxylic acid to image brain tumors. | we have developed a new tumor-avid amino acid, 1-amino-3-fluorocyclobutane-1-carboxylic acid (facbc), labeled with 18f for nuclear medicine imaging. | 1999 | 10025843 |
| anti-gq1b-positive miller fisher syndrome in a patient with acute epstein-barr virus infection and negative campylobacter serology. | | 1998 | 10026022 |
| a chimeric fusion protein of cytochrome cyp4b1 and green fluorescent protein for detection of pro-drug activating gene delivery and for gene therapy in malignant glioma. | quantity and distribution of transgene-expressing tumor cells are central issues in cancer gene therapy. these are critical for the efficiency of tumor killing and for the bystander effect. in an attempt to combine the advantages of a potent bioactivating "suicide" gene with a marker gene for living cells, cdna encoding cytochrome cyp4b1 was fused to the green fluorescent protein (gfp) cdna. the resulting chimeric fusion protein, 4b1egfp, was expressed in rodent and human glioma cell lines in cu ... | 1998 | 10026902 |
| alteration of g1 cell-cycle protein expression and induction of p53 but not p21/waf1 by the dna-modifying carcinogen 2-acetylaminofluorene in growth-stimulated hepatocytes in vitro. | 2-acetylaminofluorene (aaf) is a potent tumor promoter in rat liver carcinogenesis models. in the resistant hepatocyte model, aaf is combined with a growth stimulus for efficient promotion of preneoplastic lesions. the promoting property of aaf in this model is closely associated with mito-inhibition of normal hepatocytes, an effect to which initiated cells are resistant. how aaf induces growth arrest is not known, but genotoxic as well as non-genotoxic effects have been implicated. to elucidate ... | 1999 | 10029409 |
| transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: inducibility of cytochrome p450 dependent monooxygenase functions by beta-naphthoflavone, phenobarbital and dexamethasone. | in the present study the effects of beta-naphthoflavone (bnf), phenobarbital (pb) and dexamethasone (dex) on cytochrome p450 (p450) dependent monooxygenase functions were investigated in intrasplenic liver cell explants in comparison to adult liver. fetal liver tissue suspensions were transplanted into the spleens of 60-90 days old adult male syngenic fisher 344 inbred rats. 2, 4 or 6 months after surgery, transplant recipients and age matched controls were orally treated with bnf (1x50 mg/kg bo ... | 1999 | 10048716 |
| alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats. | ageing in mammals is characterized by a decline in plasma levels of insulin-like growth factor-1 that appears to contribute to both structural and functional changes in a number of tissues. although insulin-like growth factor-1 has been shown to provide trophic support for neurons and administration of insulin-like growth factor-1 to ageing animals reverses some aspects of brain ageing, age-related changes in insulin-like growth factor-1 or type 1 insulin-like growth factor receptors in brain ha ... | 1999 | 10051206 |
| [repetitive movements of the upper extremities: the results of assessing exposure to biomechanical overload and of a clinical study in a group of workers employed in the production of plywood and veneer panels]. | in a group of 27 female workers employed on the manual "moulding" of plywood panels exposure to factors of biomechanical overload for the upper limbs was assessed and an anamnestic and clinical examination was made in order to clarify the occurrence of a series of wmsds type diseases and disorders. data are reported on the risk factors, frequency of action (range: right limb-->14.5 divided by 22.0 actions/min,-->5.5 divided by 11.0 actions/min), use of strength (right limb-->borg 3.7-4.9; left l ... | 1998 | 10064946 |
| [an experimental study of the protective effect of lazaroid (u-74389g) on cisplatin-induced toxicity]. | lazaroids, a novel series of 21-aminosteroids without glucocorticoid action, have the properties of free radical scavenging and potent inhibition of lipid peroxidation. u-74389g is one of the lazaroid compounds. these compounds have shown excellent effect on central nervous system trauma and ischemia in experimental animals. the present study was designed to investigate whether lazaroid (u-74389g) has a protective effect on cisplatin (cddp)-induced toxicity. fisher 344 rats were used in this stu ... | 1999 | 10067316 |
| chronic shunt-dependent hydrocephalus after early surgical and early endovascular treatment of ruptured intracranial aneurysms. | the goal of this study was to document the influence of the treatment method (early surgery versus early endovascular treatment) on the development of chronic shunt-dependent hydrocephalus in a series of 242 patients treated within 7 days after aneurysmal subarachnoid hemorrhage (sah). | 1999 | 10069587 |
| blood flow influences vascular growth during tumour angiogenesis. | many factors play a role in tumour angiogenesis. we observed growing tumour vessels in vivo to study the relationship between blood flow and vascular enlargement. mammary adenocarcinoma was implanted into fisher-344 rat with dorsal skin-fold transparent chambers. vascular growth was observed and recorded on videotape through a microscope for 6 h. vascular networks were photographed and traced every 30 min to identify changes over time. tumour sections were stained with masson's trichrome and ant ... | 1999 | 10070869 |
| suppression of allograft rejection with anti-alphabeta t cell receptor antibody in rat corneal transplantation. | anti-alphabeta t cell receptor monoclonal antibody (r73) has been reported to be a potent immunosuppressant. the suppressive effects of this antibody on allograft rejection after corneal transplantation are unknown. | 1999 | 10071034 |
| modified technique of isolated left lung perfusion in the rat. | isolated lung perfusion is a novel therapy for the treatment of pulmonary metastases to increase current low survival rates. due to tumor heterogeneity, perfusion has to be evaluated in different rat species for efficacy and ideal drug regimens. the revised technique of isolated left lung perfusion as described by wang and originally performed in the fisher rat resulted in a high morbiditity in the wag/rij rat in our laboratory. therefore, we modified techniques for intubation and anesthesia, an ... | 1999 | 10072615 |
| the structure of the rat amiloride-sensitive epithelial sodium channel gamma subunit gene and functional analysis of its promoter. | prolonged dietary na+ depletion and chronic administration of adrenal steroids increase steady-state mrna levels of the gamma subunit of the epithelial sodium channel (gammaenac) in rat colon. this increase correlates with a marked increase in transepithelial na+ transport and is thought to occur via transcriptional regulation. to begin to evaluate these mechanisms in detail, we determined the organization of the rat gammaenac gene. a rat genomic library was screened and overlapping lambda clone ... | 1999 | 10072764 |
| impact of the fetal fibronectin assay on admissions for preterm labor. | the aim of the study was to determine whether use of the fetal fibronectin assay would decrease the number of admissions to labor and delivery for diagnosis and treatment of preterm labor. study design: a prospective cohort design was used to compare preterm labor admissions during a 12-month period of fetal fibronectin assay use (study) against a baseline period before fetal fibronectin assay was implemented as standard protocol. patients coming to the physician's office or hospital with signs ... | 1999 | 10076132 |
| fiber type composition of four hindlimb muscles of adult fisher 344 rats. | the limb and trunk muscles of adult rats express four myosin heavy chain (mhc) isoforms, one slow (mhci) and three fast (mhciia, mhciid, and mhciib). the distribution of these isoforms correlates with fiber types delineated using myofibrillar actomyosin adenosine triphosphatase (matpase) histochemistry. for example, type i fibers express mhci and fiber types iia, iid, and iib express mhciia, mhciid, and mhc-iib, respectively. fibers containing only one mhc isoform have been termed "pure" fibers. ... | 1999 | 10090572 |
| immune functions in the fisher rat fed beluga whale (delphinapterus leucas) blubber from the contaminated st. lawrence estuary. | in order to assess the immunotoxic potential of food naturally contaminated with pcbs and other organohalogens, fisher rats were fed a diet in which the lipids originated from the blubber of either a highly polluted st. lawrence beluga or a relatively uncontaminated arctic beluga. after a period of 2 months, different immune functions were evaluated, including lymphoblastic transformation, natural killer cell activity, plaque-forming cells, phagocytosis, oxidative burst, and immunophenotyping. f ... | 1999 | 10092424 |
| preventing deaths in alaska's commercial fishing industry. | the arctic and sub-arctic waters of alaska provide a very hazardous work setting, with special hazards posed by great distances, seasonal darkness, cold waters, high winds, brief fishing seasons, and icing. our intent is to reduce the remarkably high occupational fatality rate (200/100,000/year in 1991-1992) among alaska's commercial fishing workers. over 90% of these deaths have been due to drowning or drowning plus hypothermia, primarily associated with vessel capsizings and sinkings. | 1998 | 10093333 |
| the therapeutic potential of aloe vera in tumor-bearing rats. | aloe vera has been claimed to contain several important therapeutic properties, including anticancer effects. the effect of aloe vera administration was studied on a pleural tumor in rat. growth of yoshida ah-130 ascite hepatoma cells injected (2 x 10(5) in 0.1 ml) into pleura of male inbred fisher rats was evaluated at different times (7th and 14th days). data show that the use of aloe vera proved a therapeutic method, and that the present experimental model could be useful in the study of othe ... | 1998 | 10093794 |
| paradoxical gh response to trh during status epilepticus in man. | information on gh in relation to epilepsy is sparse, and to our knowledge there is no information on gh levels during status epilepticus in man. we studied gh in serum in six patients during status epilepticus, and in a control group of six seizure-free patients with epilepsy, before and after injection of trh. the baseline gh values before trh administration were within the normal range in all patients. after injection of trh all patients with status epilepticus showed a paradoxical peak-shaped ... | 1999 | 10097249 |
| [bcg vaccine. its efficacy and impact on the results of tuberculin screening in a high-risk population]. | in a housing estate population with a high prevalence of tuberculosis, the authors conducted tuberculosis screening with the tuberculin test, and an investigation with three purposes: evaluation of tuberculosis infection (defined as > 10 mm on tuberculin test), evaluation of bcg effect on tuberculin test, and evaluation of bcg efficacy. the data was collected by nurses during the screening and completed with observation of vaccination records in a health center. the diagnosis of tuberculosis was ... | 1998 | 10192980 |
| hemodialysis access: influence of the human immunodeficiency virus on patency and infection rates. | the complication rate for patients who are dialysis dependent and infected with the human immunodeficiency virus (hiv) and the role of viral indicators (cd4 counts) as predictors of these complications are poorly characterized. to determine the influence of hiv status and viral activity on graft patency and infection rates, we retrospectively reviewed our results. | 1999 | 10194487 |
| effects of cholinergic depletion on evoked activity in the cortex of young and aged rats. | degeneration of cholinergic neurons in the basal forebrain is a neural marker of alzheimer's disease and is associated with perceptual and cognitive deficits. an idea that has attracted scientific scutiny is that aging makes the brain more susceptible to neurodegenerative diseases such as alzheimer's. the purpose of this study was to compare the effects of the loss of cholinergic input from nucleus basalis of meynert on evoked activity in the posteromedial barrel subfield of the somatosensory co ... | 1998 | 10198812 |
| tests used to assess the cognitive abilities of aged rats: their relation to each other and to hippocampal morphology and neurotrophin expression. | aged rodents have proven to be a useful tool in studying age-related cognitive decline, particularly with regard to hippocampal function. a number of maze tests have been developed to evaluate hippocampal function in aged rodents, including the eight-arm radial maze, barnes circular platform maze and morris water maze. to some extent, these mazes have been used interchangeably to evaluate aged animals. few researchers, however, have examined how performance of individual, aged animals compares i ... | 1999 | 10202259 |
| an evaluation of the co2 laser for endodontic disinfection. | the goal of this study was to evaluate the bactericidal action of the co2 laser on animal teeth infected with an endodontic bacterial species. after instrumentation, 24 freshly extracted incisors were inoculated with a known concentration of actinomyces odontolyticus and incubated anaerobically for 18 h. the incisors were separated into three groups: group 1--untreated control teeth; group 2--teeth treated with 3% naocl; and group 3--teeth lased with a co2 laser at 5 w using three successive 9.9 ... | 1999 | 10204466 |
| parameter estimation from rician-distributed data sets using a maximum likelihood estimator: application to t1 and perfusion measurements. | general expressions are presented to calculate the maximum likelihood (ml) estimator and corresponding fisher matrix for rician-distributed data sets. this estimator results in the most precise, unbiased estimations of t1 from magnitude data sets, even when low signal-to-noise ratios (<6) are present. by optimizing the sample point distributions for inversion-recovery experiments, a 32% increase in precision of the estimated t1 is obtained, compared with a linear sampling scheme. perfusion rates ... | 1999 | 10204887 |
| pseudomonas aeruginosa outer-membrane protein f epitopes are highly immunogenic in mice when expressed on a plant virus. | a synthetic peptide (peptide 10) representing a surface-exposed, linear b cell epitope from outer-membrane (om) protein f of pseudomonas aeruginosa was shown previously to afford protection in mice from p. aeruginosa infection. this peptide was expressed in tandem with the protein f peptide 18 on each of the two coat proteins of cowpea mosaic virus (cpmv). the chimaeric virus particles (cvps) expressing the peptides on the s (small) coat protein (cpmv-pae4) and l (large) coat protein (cpmv-pae5) ... | 1999 | 10206701 |
| enhancement of tnf-alpha production by ganglioside gm2 in human mononuclear cell culture. | some gangliosides have been regarded as autoantigens of immune-mediated neurological disorders such as guillain-barré syndrome (gbs), miller fisher syndrome and multifocal motor neuropathy. on the other hand, proinflammatory cytokines, such as tumor necrosis factor-alpha (tnf-alpha) and interferon-gamma (ifn-gamma), may be important in the pathogenesis of some neuroimmunological disorders. to clarify the interactions between immune cells and gangliosides, we investigated the effects of gangliosi ... | 1999 | 10208534 |
| megalin (gp330) is an endocytic receptor for thyroglobulin on cultured fisher rat thyroid cells. | we recently reported that megalin (gp330), an endocytic receptor found on the apical surface of thyroid cells, binds thyroglobulin (tg) with high affinity in solid phase assays. megalin-bound tg was releasable by heparin. here we show that fisher rat thyroid (frtl-5) cells, a differentiated rat thyroid cell line, can bind and endocytose tg via megalin. we first demonstrated that frtl-5 cells express megalin in a thyroid-stimulating hormone-dependent manner. evidence of tg binding to megalin on f ... | 1999 | 10212279 |
| the et(a) receptor blocker lu 135252 prevents chronic transplant nephropathy in the "fisher to lewis" model. | the effect of the orally highly bioavailable and specific endothelin a (et(a)) receptor antagonist lu 135252 was assessed in a model of chronic renal allograft nephropathy. kidneys of fisher rats were orthotopically grafted to lewis rats. fisher autografts and kidneys after uninephrectomy served as controls. all animals received low-dose cyclosporin a (csa; 1.5 mg/kg body wt) for 10 d after surgery. allotransplanted animals were then randomized to receive standard diet or a diet designed to deli ... | 1999 | 10215340 |
| dyract compomer: comparison of total etch vs. no etch technique. | different dental materials and methods can influence the integrity of the marginal seal of restorations. to evaluate the microleakage of dyract ap light cured compomer, a polyacid modified resin (caulk), using etched and unetched techniques, standardized trapezoidal class v restorations were placed on facial or lingual surfaces of 20 human molars with the gingival margin in the cementum. each restoration was scored at the cervical by two independent, double blinded operators, with reference to t ... | 1998 | 10218026 |
| [endonasal mupirocin in the prevention of nosocomial pneumonia]. | to evaluate efficacy of mupirocin ointment nasal application in prevention of mrsa ventilatory associated pneumonia (vap). | 1999 | 10218362 |
| involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat. | free radicals have been suggested to be largely involved in the genesis of ischemic brain damage, as shown in the protective effects of alpha-phenyl-n-tert-butyl nitrone (pbn), a spin trapping agent, against ischemic cerebral injury. in the present study, the effects of pbn as well as mci-186, a newly-developed free radical scavenger, and oxypurinol, an inhibitor of xanthine oxidase, were evaluated in a rat transient middle cerebral aretery (mca) occlusion model to clarify the possible role of f ... | 1999 | 10218662 |
| distribution of small magnetic particles in brain tumor-bearing rats. | small (10-20 nm) uncharged magnetic particles (smp) were evaluated for their ability to target intracerebral rat glioma-2 (rg-2) tumors in vivo. in an effort to determine the influence of particle size on blood-tumor barrier uptake, the tissue distribution of the injected particles was evaluated following intraarterial injection (4 mg/kg smp) in male fisher 344 rats bearing rg-2 tumors with a magnetic field of 0 g or 6000 g applied to the brain for 30 min. animals were sacrificed at 30 min or 6 ... | 1999 | 10222429 |
| distinct immunoglobulin class and immunoglobulin g subclass patterns against ganglioside gq1b in miller fisher syndrome following different types of infection. | we studied serum antibodies against gangliosides gq1b and gm1 in 13 patients with miller fisher syndrome (mfs) and in 18 patients with guillain-barré syndrome (gbs) with cranial nerve involvement. anti-gq1b titers were elevated in all patients with mfs cases (immunoglobulin g [igg] > iga, igm), and in 8 of the 18 with gbs. lower frequencies of increased anti-gm1 titers were observed in mfs patients (3 of 13), as well as in gbs patients (5 of 18). during the course of mfs, anti-gq1b titers of all ... | 1999 | 10225903 |
| inhibitory effect of deferoxamine mesylate and low iron diet on the 13762nf rat mammary adenocarcinoma. | the iron chelator deferoxamine mesylate has been shown to inhibit the growth of a variety of human malignant cell lines and the rat 13762nf mammary adenocarcinoma cell line. in vivo studies in mice have also demonstrated that an iron deficiency induced by either feeding a low iron diet or injecting the iron chelator deferoxamine mesylate decreases tumor growth. in this study fisher rats were transplanted with the 13762nf mammary adenocarcinoma and divided into four groups: normal diet, normal di ... | 1999 | 10226580 |
| effect of normobaric hyperoxia on two indexes of synaptic function in fisher 344 rats. | the physiological response of two central nervous system neurotransmitter receptors to oxidative stress was studied using the rat model of hyperoxia. we show that hyperoxia leads to a decline in the ability of isoproterenol (iso) to augment gabaergic responses in cerebellar purkinje neurons in vivo. this effect is reversed by the n-tert-butylalpha-phenylnitrone (pbn). we also show that hyperoxia produces a decline in the ability of oxotremorine (oxo) to stimulate dopamine (da) release in striata ... | 1999 | 10232824 |
| the effects of gonadectomy on bone size, mass, and volumetric density in growing rats are gender-, site-, and growth hormone-specific. | peak volumetric bone mineral density (bmd) is determined by the growth in bone size relative to the mineral accrued within its periosteal envelope. thus, reduced peak volumetric bmd may be the result of reduced mineral accrual relative to growth in bone size. because sex steroids and growth hormone (gh) influence bone size and mass we asked: what are the effects of gonadectomy (gx) on bone size, bone mineral content (bmc), areal and volumetric bmd in growing male and female rats? does gh deficie ... | 1999 | 10320529 |
| prospective follow-up and pulmonary functions from a placebo-controlled randomized trial of ribavirin therapy in respiratory syncytial virus bronchiolitis. ribavirin study group. | to determine any long-term differences in adverse effects and pulmonary function between infants with respiratory syncytial virus and lower respiratory tract infection who were treated with ribavirin and a control group. | 1999 | 10323626 |
| dose-response relationships for hepatic aflatoxin b1-dna adduct formation in the rat in vivo and in vitro: the use of immunoslot blotting for adduct quantitation. | an immunoslot blotting (isb) method for quantitating aflatoxin b1-dna adduct levels has been developed and used to examine the relationship between dose and hepatic aflatoxin b1-dna adduct levels in rats fed aflatoxin b1 (afb1) in the diet at dose levels of between 0.5 and 10 micrograms/kg/day. the method has also been used to examine the dose-response relationship for adduct formation in precision-cut rat liver slices incubated with afb1 at concentrations between 0.01 and 2 microm. for the feed ... | 1999 | 10332812 |
| functional significance of the conserved residues in the flexible hinge region of the myosin motor domain. | analysis of the three-dimensional crystal structure of the dictyostelium myosin motor domain revealed that the myosin head is required to bend at residues ile-455 and gly-457 to produce the conformation changes observed in the ternary complexes that resemble the pre- and post-hydrolysis states (fisher, a. j., smith, c. a., thoden, j. b., smith, r., sutoh, k., holden, h. m., and rayment, i. (1995) biochemistry 34, 8960-8972). asp-454, ile-455, and gly-457 of smooth muscle myosin were substituted ... | 1999 | 10347200 |
| effect of chlorpyrifos on immune function in rats. | a commercial formulation of chlorpyrifos was evaluated for effects on selected immune system functions in male fisher 344 rats. chlorpyrifos in an olive oil vehicle was administered by oral gavage twice weekly for 28 d at a dose of 5.0 mg/kg for each treatment. body weight and organ/body weight ratios were unaffected by the chlorpyrifos. in contrast, chlorpyrifos impaired t-lymphocyte blastogenesis induced by concanavalin a (p = 0.03) and phytohemagglutinin (p = 0.023), but did not alter b-lymph ... | 1999 | 10349701 |
| anti-ganglioside antibodies can bind peripheral nerve nodes of ranvier and activate the complement cascade without inducing acute conduction block in vitro. | the neurophysiological effects of nine neuropathy-associated human anti-ganglioside antisera, three monoclonal antibodies to ganglioside gm1 (gm1) and of the cholera toxin b subunit (a gm1 ligand) were studied on mouse sciatic nerve in vitro. gm1 antisera and monoclonal antibodies from patients with chronic motor neuropathies and guillain-barre syndrome, and gq1b/ disialosyl antisera and monoclonal antibodies from patients with chronic ataxic neuropathies and miller fisher syndrome were studied. ... | 1999 | 10355667 |
| tp53 tumor suppressor protein in normal human fibroblasts does not respond to 837 mhz microwave exposure. | the tp53 tumor suppressor protein (formerly known as p53) responds to a wide variety of environmental insults. to evaluate the safety of cellular telephones, tp53 responses in human fibroblast cells were studied after exposure to 837 mhz microwaves. cells were exposed in a temperature-controlled transverse electromagnetic (tem) chamber to a specific absorption rate (sar) of 0.9 or 9.0 w/kg at 837 mhz continuous-wave (cw) microwave irradiation for 2 h. the tp53 protein levels were measured by wes ... | 1999 | 10360791 |
| effects of exonuclease activity and nucleotide selectivity of the herpes simplex virus dna polymerase on the fidelity of dna replication in vivo. | a mutagenesis system was developed for the in vivo study of the fidelity of dna replication mediated by wild-type herpes simplex virus type 1 (hsv-1) strain kos and its polymerase (pol) mutant derivatives paar5, y7, and yd12. the phos1 shuttle plasmid, which contained the supf mutagenesis marker gene and the hsv oris sequence, was used for analysis of the mutation frequency and the mutation spectrum. all three pol mutants induced significant increases in the mutation frequencies of the target ge ... | 1999 | 10364279 |
| neuroprotective effects of basic fibroblast growth factor following spinal cord contusion injury in the rat. | cytokines and neurotrophic factors have been implicated in the pathophysiology of injury to the central nervous system. while some cytokines are considered pro-inflammatory, other factors promote neuronal growth and survival. the present study investigated the neuroprotective effects of interleukins 1 (il-1), 4 (il-4), and 6 (il-6), nerve growth factor (ngf), ciliary neurotrophic factor (cntf), and basic fibroblast growth factor (bfgf) in a contusion model of spinal cord injury. female sprague-d ... | 1999 | 10369555 |
| the effect of thyrotropin receptor antibodies on the proliferation of frtl-5 cells and the expression of protooncogene c-fos mrna. | hyperthyroidism and a diffuse goiter are the main symptoms of graves' disease (gd) associated with autoantibodies to thyroid-stimulating hormone (tsh) receptor (trab). the present study was conducted to evaluate effects of autoantibodies in patients with gd (trab-igg) on induction of the proliferation and c-fos mrna expression in frtl-5 cells (fisher rat thyroid cell line). | 1998 | 10374349 |
| [antiganglioside antibodies in the pathogenesis of autoimmune neuropathies]. | antiganglioside antibodies are frequently detected in sera from patients with autoimmune neuropathies, such as guillain-barré syndrome, miller fisher syndrome, igm paraproteinemic neuropathy, chronic inflammatory demyelinating polyneuropathy, and multifocal motor neuropathy. in the acute phase sera from gbs patients, antiganglioside antibodies are detected in 60-70%. ganglioside antigens recognized by serum antibodies are varied from case to case. igg antibody against gq1b ganglioside is specifi ... | 1999 | 10377820 |
| glutamine protects against doxorubicin-induced cardiotoxicity. | doxorubicin (dox) dose-intensive therapy for breast cancer is limited by a cardiomyopathy that often results in overt congestive heart failure. we hypothesized that dietary glutamine (gln) can diminish dox-induced cardiotoxicity by maintaining tissue glutathione (gsh) levels and thus preventing the proposed mechanism of cardiac injury: oxidation. | 1999 | 10383856 |
| 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (phip) retards mammary gland involution in lactating sprague-dawley rats. | 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (phip), a compound from cooked meat, is an established mammary gland carcinogen in female rats. four doses of phip (150 mg/kg, p.o., once per day) were given to lactating sprague-dawley rats separated from their 10-day-old pups to initiate involution of the gland. twenty-four hours after the last dose, apoptotic index in the mammary gland, as measured by the tunel assay, was significantly higher in the gland from control rats than in the phip-treat ... | 1999 | 10383905 |
| the predictive value of endometrial stripe thickness in patients with suspected ectopic pregnancy who have an empty uterus at ultrasonography. | prior research suggests that, in patients with empty uteri at ultrasonography, endometrial stripe thickness may be predictive of ectopic pregnancy or the likelihood of obtaining chorionic villi after a dilatation and evacuation procedure (d+e). however, it is unclear whether the predictive value of endometrial stripe thickness is confined to patients with low beta-human chorionic gonadotropin (beta-hcg) values. | 1999 | 10386677 |
| the prophylactic use of transluminal balloon angioplasty in patients with fisher grade 3 subarachnoid hemorrhage: a pilot study. | recent advances in neuroradiology have made it possible to dilate vasospastic human cerebral arteries after aneurysmal subarachnoid hemorrhage (sah), but the time window is short and the success rate for reversal of delayed ischemic neurological deficits (dinds) varies between 31% and 77%. in a dog model of vasospasm, transluminal balloon angioplasty (tba) performed on day 0 totally prevented the development of angiographically demonstrated narrowing on day 7. because the effect of preventive tb ... | 1999 | 10389880 |
| [a case of atypical miller fisher syndrome associated with antiphospholipid antibodies]. | we report a 56-year-old man with external ophthalmoplegia and ataxic gait following a diarrhea, being diagnosed atypical miller fisher syndrome (fs). on admission, he had severe diplopia and bilateral external ophthalmoplegia were observed. the deep tendon reflexes were decreased on the right upper extremity. he could not walk straight and his tandem gait was impaired. serum igg anticardiolipin antibody (acl) and aptt-lupus anticoagulant (la) were found to be increased. the serum of the patient ... | 1999 | 10391971 |
| temporal patterns of dna adduct formation and glutathione s-transferase activity in the testes of rats fed aflatoxin b1: a comparison with patterns in the liver. | fisher-344 male rats were fed 1.6 ppm of aflatoxin b1 (afb1) continuously and intermittently for several weeks. at various time periods, dna was isolated from the testes and livers and analyzed for afb1-dna adducts. the ability of the testis to detoxify afb1 was also investigated by the glutathione s-transferase (gst) activity assay and compared with that of the liver. the levels of testicular afb1-dna adducts were 2.4 to 8.1 times lower than those of the liver after 4 to 16 weeks of continuous ... | 1999 | 10398377 |
| hemorrhagic shock impairs mucosal immunity to gut-derived antigens. | secretory immunoglobulin a (siga) is the principal antibody protecting against pathogens in the respiratory tract and other mucosal surfaces. nosocomial pneumonias are frequent after injury and critical illness and are often due to enteric pathogens. the aim of this study was to assess the relative effect of hemorrhagic shock (hs) on mucosal immunity at intestinal and respiratory mucosal sites. fisher rats were immunized intragastrically with dinitrophenylated (dnp) pneumococcus (pn). three week ... | 1999 | 10399972 |
| inhibition of endothelin-converting enzyme attenuates transplant vasculopathy and rejection in rat cardiac allografts. | transplant vasculopathy in kidney and heart allografts is associated with marked elevation of endothelin-1 (et-1), but a role for et-1 in the pathogenesis of transplant vasculopathy and chronic rejection has not been established. we, therefore, tested whether inhibition of et-1-converting enzyme by phosphoramidon (pa) would attenuate rejection in a rat model of chronic cardiac allograft rejection (lewis [lew] to f344). | 1999 | 10401760 |