| short-term treatment of trichomonas vaginalis with tioconazole cream, a new antifungal agent. | | 1983 | 6873746 |
| antibiotic a 19009. structural investigation and synthesis. | the structure of fermentation product a 19009 was reinvestigated by 13c and 1h nmr spectroscopy and established by independent synthesis to be n2-l-alanyl-n3-fumaramoyl-l-2,3-diaminopropanoic acid (2), i.e. a structure isomeric with the originally proposed structure 1. in contrast to 1 which also was synthesized, 2 has a very low activity against trichomonas vaginalis. | 1983 | 6885634 |
| sexually transmitted diseases in clinic patients in lagos. | in a study of patients attending an std referral clinic in lagos, nigeria, the age distribution was similar to that seen on other parts of the world and the male-to-female ratio was 1.3:1. non-specific genital infection was diagnosed in about 59% of patients and gonorrhoea in 19%. most strains of neisseria gonorrhoeae were sensitive to penicillin (1 unit) and the six relatively penicillin-resistant strains did not produce penicillinase. candidosis and trichomoniasis were each diagnosed in about ... | 1980 | 6892789 |
| the clinical diagnosis of trichomoniasis. | two hundred twenty-six consecutive women attending an inner-city clinic for sexually transmitted diseases were evaluated. problem-directed histories and physical examinations were conducted and vaginal specimens for wet preparation and trichomonas vaginalis culture were obtained from each patient. one hundred patients were found to be infected. patients with multiple sex partners were found to be at increased risk of trichomoniasis (p less than .05). those with abnormal discharge noted on examin ... | 1982 | 6896368 |
| metronidazole: in vitro activity, pharmacology and efficacy in anaerobic bacterial infections. | metronidazole is a 5-nitroimidazole that has selective activity against anaerobic microorganisms, including bacteria and protozoa. intravenous metronidazole has recently been approved by the u.s. food and drug administration for the treatment of serious anaerobic bacterial infections. it is usually bactericidal at low concentrations, and its spectrum of activity encompasses almost all anaerobic bacteria and some capnophilic organisms. anaerobic bacteria known to be resistant to metronidazole inc ... | 1981 | 6927601 |
| action of clinically utilized 5-nitroimidazoles on microorganisms. | various nitroimidazoles are used as antimicrobial and radiosensitizing agents in human medicine. of these, 5-nitroimidazoles show high selective toxicity for anaerobic prokaryotes and eukaryotes. this review discusses the effects of 5-nitroimidazoles on microorganisms, i.e. microbicidal action, radiosensitizing action, inhibition of photosynthetic microorganisms, and induction of mutations. all these actions are enhanced by anaerobiosis and inhibited by aerobiosis or by the presence of certain r ... | 1981 | 6941454 |
| natural cell-mediated cytotoxicity against trichomonas vaginalis in the mouse. i. tissue, strain, age distribution, and some characteristics of the effector cells. | | 1980 | 6965381 |
| trichomonas vaginalis: reevaluation of its clinical presentation and laboratory diagnosis. | vaginal discharge is the most common complaint and trichomonas vaginalis vaginitis the most frequently diagnosed problem among women attending the dekalb county georgia, veneral disease clinic. despite this prevalence, the 1837 observations of donné are the criteria frequently used in the clinical and laboratory diagnosis of trichomoniasis. our study shows that a purulent, frothy discharge is indeed a characteristic of trichomonal vaginitis, but if it is used as the sole diagnostic criterion, 88 ... | 1980 | 6965976 |
| urine culture for the detection of trichomonas vaginalis in men. | urine samples were collected from 248 men, 21 of whom were known contacts of women infected with trichomonas vaginalis. this organism was cultured from only three of the 21 specimens from patients in the contact group. the cultural technique was shown to be capable of reliably detecting small numbers of organisms under practical conditions; it appears, therefore, that most male contacts shed relatively few trichomonads and that the infective dose for women must be correspondingly small. | 1980 | 6966175 |
| [new dry nutrient medium made of nonfood stock for culturing vaginal trichomonads]. | | 1980 | 6967245 |
| [removal of accompanying yeast fungi from cultures of trichomonad strains (polymastigina)]. | for purifying the cultures of trichomonas vaginalis and t. hominis from associating yeasts we inoculated them into the upper layer of a viscous medium containing 0.1% agar (teras, 1955; tompel, teras, 1976) poured into a burette. on the 2nd or 3rd day after inoculating the first drops obtained from the lower end of the burette contained as a rule only trichomonads. for purifying the cultures of t. tenax from associating yeasts we prepared a special semisolid medium from the liquid egg medium (wa ... | 1980 | 6967578 |
| [effect of orotic acid, hypoxanthine and arginine hydrochloride on the development of a vaginal trichomonad culture]. | | 1980 | 6967658 |
| trichomoniasis. new ideas on an old disease. | trichomoniasis is probably the most widespread sexually transmitted disease of man. the causative organism, trichomonas vaginalis, can normally be found on microscopic examination of vaginal exudate, although serological diagnostic techniques have recently been described. the organism has now been recognized as a pathogen, and, although infection has been associated with cervical cancer, a causative link has not been established. despite both humoral and cellular immune responses, protective imm ... | 1980 | 6969449 |
| measuring the in vitro susceptibility of trichomonas vaginalis to metronidazole: a disk broth method. | strains of trichomonas vaginalis were evaluated for their in vitro responses to metronidazole. a serial twofold dilution method that measured minimal inhibitory concentrations (mics) by cessation of trophozoite motility was compared with the disk broth method, in which both cessation of motility and inhibition of trophozoite proliferation were used for measurement of mics. these methods gave comparable results in distinguishing a metronidazole-resistant and two metronidazole-susceptible strains ... | 1980 | 6969450 |
| trichomonas vaginalis associated with nongonococcal urethritis and prostatitis. | trichomonas vaginalis was recovered from three (1.7%) of 179 men with nongonococcal urethritis. prostatitis was found in 11 (8%) of 138 of these men who had prostatic examinations; t. vaginalis was recovered from two of the 11. serologic evidence (an indirect hemagglutination titer of greater than or equal to 1:80) was found in 20 (14%) of 146 men; four of the 20 had prostatitis and two of these had prostatitis associated with t. vaginalis. in a group of 26 men with urethritis and prostatitis as ... | 1980 | 6969451 |
| [a systematic search for ureaplasma urealyticum in vaginal swabs. the results (author's transl)]. | 6.6 per cent 1.069 vaginal swabs showed ureaplasma urealyticum in our patients. ureaplasma does not seem to alter the cytology or the physiological flora of the vagina. on the other hand trichomonas vaginalis was often found in association with it. there is no racial predisposition to infection of the vagina with ureaplasma. pregnancy, however, does seem to favour the growth of this mycoplasma. but this does not seem to have any adverse effect on the progress of the pregnancy. | 1980 | 6969736 |
| metronidazole. | | 1981 | 6970332 |
| [occurrence of trichomoniasis in women with intra-uterine devices (author's transl)]. | the authors investigated the biocenosis in the vaginas of 216 women with iud and 124 controls without any contraceptive. the incidence of vaginal trichomoniasis in iud probands was higher with significance than that among the controls. culture testing is indispensable to rule out the presence of vaginal trichomoniasis. parasites were not readily detectable from stained and native specimens unless infections were massive. the cytological findings recorded from the above probands were within the n ... | 1980 | 6970467 |
| new chemotherapeutic nitroheterocycles active against 5-nitroimidazole-resistant strains of trichomonads. | the synthesis and the trichomonacidal activity of some 4-substituted 2-imidazolylquinazoline derivatives are described. the new compounds were highly active against metronidazole-sensitive and metronidazole-resistant strains of trichomonads. this was demonstrated in vitro as well as in various trichomoniasis models in mice and rats after oral treatment. | 1981 | 6971111 |
| behaviour and pathogenicity of trichomonas vaginalis in epithelial cell cultures: a study by light and scanning electron microscopy. | the behaviour and pathogenic effects of trichomonas vaginalis in mammalian cell cultures were studied using light microscopy and scanning electron microscopy. six hours after inoculation of the parasites into the cell cultures about 10% of the epithelial monolayer was destroyed. the parasites adhered to the epithelial cells, developed an amoeboid morphology, and crawled over and under the monolayer of cells. these observations suggest that the adhesiveness, amoeboid morphology, and motility of t ... | 1981 | 6971140 |
| a comparison of four media for the cultivation of trichomonas vaginalis. | | 1981 | 6971152 |
| lectin analysis of surface saccharides in two trichomonas vaginalis strains differing in pathogenicity. | | 1980 | 6971328 |
| [in vitro studies on the identification of metronidazole resistant strains of trichomonas vaginalis (author's transl)]. | in order to ascertain the minimal lethal concentration (mlc) of metronidazole for strains of t. vaginalis with varying susceptibility, comparative studies were carried out under different assay conditions. these studies were made under aerobic or anaerobic conditions in microtiter plates and culture tubes respectively, using the following media: cach with/without agar, cplm, trichomonas medium (merck), fluid thioglycollate (bbl), tym with/without agar and sts modified. thus only mlc values great ... | 1981 | 6971538 |
| ankylosing spondylitis associated with trichomonas vaginalis infection. | a patient is described who developed signs and symptoms of ankylosing spondylitis after prostatitis due to trichomonas vaginalis. chronic prostatitis of unknown cause had previously been reported as being common in patients with ankylosing spondylitis. the observations in this case raise the possibility that t. vaginalis might play a role in the prostatitis and pathogenesis of ankylosing spondylitis in some patients. | 1981 | 6972386 |
| the sensitivity of trichomonas vaginalis and trichomonas gallinae to ultraviolet radiation. | | 1981 | 6973159 |
| [the flagellate trichomonas vaginalis and its bacterial environment in vaginal medium]. | | 1981 | 6973309 |
| new defined and semi-defined media for cultivation of the flagellate trichomonas vaginalis. | studies on the nutrition and physiology of trichomonas vaginalis have been hampered by the lack of a defined synthetic medium in which to grow the organism. new synthetic media free of ill-defined supplements and serum which support good growth of t. vaginalis have been developed in this study. the first successful approach to a defined medium resulted from the modification of the tissue-culture medium cmrl 1066. essential modifications included (1) lowering the redox potential of the medium by ... | 1981 | 6973740 |
| mechanisms of selective toxicity of metronidazole and other nitroimidazole drugs. | | 1981 | 6974031 |
| preliminary observations on human vaginal and intestinal trichomonads. | | 1981 | 6975335 |
| in vitro susceptibility of trichomonas vaginalis to zinc. | the prostate has long been considered to be a site of sequestration of trichomonas vaginalis. from this reservoir, organisms are thought to be shed during intercourse and produce repeated infections in the female genitourinary tract. bacteria known to cause prostatitis are inhibited by concentrations of zinc found in uninfected prostatic secretions. the present study demonstrates a similar inhibitory effect of zinc on the growth of t. vaginalis. this finding would suggest that, in otherwise heal ... | 1981 | 6975472 |
| relationship between size of trichomonas vaginalis and pathogenicity. | | 1981 | 6975756 |
| [biological characteristics of trichomonas vaginalis]. | | 1981 | 6976202 |
| trichomonas vaginalis: dependence of resistance among different mouse strains upon the non-h-2 gene haplotype, sex, and age of recipient hosts. | | 1981 | 6976269 |
| [urethro-prostatitis caused by trichomonas vaginalis]. | | 1981 | 6977175 |
| trichomonas vaginalis infection of the median raphe of the penis. | a case of trichomonas vaginalis infection involving the median raphe of the penis is presented. the infection was contracted after sexual exposure. the patient had no urethral discharge but had a penile swelling tht discharged pus. microscopic examination and culture of the discharge showed the presence of t. vaginalis. treatment with metronidazole (250 mg thrice daly for seven days) eradicated the infection, but the swelling remained and a cyst was excised. one month after the surgical procedur ... | 1981 | 6977195 |
| bare trichomonas vaginalis nuclei in cervicovaginal smears. | | 1982 | 6977980 |
| [testing the effects of hydrazones and osazones of sugars on trichomonas vaginalis (author's transl)]. | | 1982 | 6978755 |
| [study on resistant forms of trichomonas vaginalis (author's transl)]. | we have demonstrated resistant forms of trichomonas vaginalis studied their morphology and induced transformation into vegetative forms. this work has led to an hypothesis concerning the parasite cycle which may throw light on the problems of transmission and resistance to therapeutic agents. | 1982 | 6979287 |
| comparative efficacy of go 10213 and some nitroimidazoles against trichomonas vaginalis and t. foetus in mice infected subcutaneously. | | 1982 | 6979983 |
| polymorphonuclear cell chemotaxis to secretions of pathogenic and nonpathogenic trichomonas vaginalis. | polymorphonuclear cell chemotaxis to secretions of pathogenic and nonpathogenic strains of trichomonas vaginalis were investigated. cells from three groups, laboratory workers, patients with urogenital symptoms, and asymptomatic patients attending an antenatal clinic, all showed greater response to secretions of pathogenic strains, when the secretion was dilute. at higher concentrations of secretion, responses to both strains were similar, except in the pregnant group, where increased chemotaxis ... | 1982 | 6980268 |
| isoenzyme characterisation of trichomonas vaginalis. | clones of 32 strains of trichomonas vaginalis isolated from patients attending a venereal diseases clinic were compared among themselves and with authentic pentatrichomonas hominis on the basis of their isoenzyme patterns for eight enzymes by thin-layer starch-gel electrophoresis. the enzymes examined were: glucose phosphate isomerase (gpi); phosphoglucomutase (pgm); malic enzyme (nadp+) (me); hexokinase (hk); malate dehydrogenase (nad+) (mdh); glucose-6-phosphate dehydrogenase (g6pd); aldolase ... | 1982 | 6980685 |
| [round forms of trichomonas vaginalis and their importance in the diagnosis of trichomoniasis (author's transl)]. | | 1982 | 6980798 |
| non-gonococcal urethritis in males--a preliminary study. | | 1982 | 6980829 |
| canine prostatic secretions kill trichomonas vaginalis. | the zinc content of prostatic secretions is thought to be an important nonspecific defense against urinary tract infection in men. this investigation measured killing by prostatic fluid of trichomonas vaginalis, a common sexually transmitted pathogen, and related this activity to zinc concentration. we used a canine model which closely resembles the human male genital tract. prostatic secretions from all dogs killed all t. vaginalis isolates. there appear to be several mechanisms for killing of ... | 1982 | 6980837 |
| zinc sensitivity of trichomonas vaginalis: in vitro studies and clinical implications. | the high zinc concentration (2.3-15.3 mm) in human prostatic secretions may be an important defense of the male lower urinary tract against infection by trichomonas vaginalis. trichomonads were rapidly killed by zinc salts at concentrations similar to those in prostatic fluid of normal men. there was some variation in the zinc sensitivity of 15 clinical isolates of t. vaginalis (minimal inhibitory concentration, 0.8-6.4 mm). a time-kill technique showed subtle differences in the kinetics of zinc ... | 1982 | 6980958 |
| [trichomonal infections in promiscuous women]. | vaginal swabs taken from 2,096 promiscuous women were examined microscopically and more swabs from 1,813 women were cultivated. the women examined were divided into 4 different age groups (15-20 years, 21-25 years, 26-30 years and over 30 years). the occurrence of trichomonadosis was diminishing with the age: 65.0%--51.2%--47.7%--41.8%. the occurrence of gonorrhoea was bit lower among the youngest women (25.9%) than among the older ones, the lowest occurrence being among the group of over 30 yea ... | 1982 | 6982010 |
| evaluation of an enzyme-linked immunosorbent assay for the detection of antibody to trichomonas vaginalis in sera and vaginal secretions. | using a whole-cell antigen antibody to trichomonas vaginalis was measured by an enzyme-linked immunosorbent assay (elisa). igg antibody was found in sera from only three of 99 children under 12 years of age. in contrast, serum igg or igm antibody or both were detected in 80.4% of women who had vaginal trichomoniasis and in 13.7% of uninfected women. although antibody was found in cervical and vaginal secretions, the correlation between current infection and the presence of antibody was poorer th ... | 1982 | 6982095 |
| antibody to trichomonas vaginalis in human cervicovaginal secretions. | human cervicovaginal secretions were obtained from patients at the gynecology and obstetrics clinics at national taiwan university hospital and cathay general hospital, republic of china. among the 500 patients examined, 33 (6.6%) were infected with trichomonas vaginalis as determined by the culture method. secretions from 24 of the infected patients and 30 noninfected women were assayed for anti-t. vaginalis immunoglobulins by the indirect immunofluorescent antibody technique. a few serum sampl ... | 1982 | 6982231 |
| the absence of cardiolipin in hydrogenosomes of trichomonas vaginalis and tritrichomonas foetus. | | 1982 | 6982325 |
| [laboratory diagnosis of urogenital trichomoniasis in dermatovenerologic dispensaries]. | | 1982 | 6983195 |
| screening for sexually transmissible infections in unwanted pregnancy. | | 1982 | 6983362 |
| metronidazole resistance of trichomonas vaginalis as a cause of treatment failure in trichomoniasis--a case report. | six isolates of a strain (mrp-mt) of trichomonas vaginalis obtained from a woman before and after unsuccessful treatment with metronidazole had an appreciably lower susceptibility to metronidazole both in vitro in the aerobic tube assay and in vivo in the mouse assay than did control strains from patients cured with standard doses of the drug. our results support recent evidence that metronidazole-resistant strains of t vaginalis do cause treatment failure. resistance of these strains could be d ... | 1982 | 6983379 |
| sensitivity of trichomonas vaginalis to metronidazole in medium with different concentrations of iron and ascorbate. | | 1982 | 6983569 |
| [a strain of trichomonas vaginalis with reduced sensitivity for metronidazole]. | | 1982 | 6983659 |
| trichomonas vaginalis urinary tract infection in an infant. | | 1982 | 6984181 |
| [determination of trichomonas vaginalis sensitivity to nitroimidazole group preparations using solid nutrient media]. | | 1982 | 6984259 |
| [trichomoniasis. diagnostic problems]. | | 1982 | 6984684 |
| [vaccination with solco trichovac. immunological aspects of a new principle in the therapy and prevention of reinfection of trichomoniasis in women]. | | 1982 | 6984685 |
| [changes in the vaginal flora of trichomoniasis patients during solco trichovac vaccination]. | | 1982 | 6984686 |
| immunocytochemical identification of trichomonads. | trichomonas vaginalis is one of the more common pathogens of the genitourinary tract. morphologic studies of trichomonal infections, however, have been hampered by the fragile nature of these thin-walled flagellates and the lack of specific histochemical procedures to identify the fragmented organisms found in tissue sections. these limitations have usually restricted positive identification to smears of freshly obtained specimens. in an attempt to overcome these limitations, a rabbit antiserum ... | 1980 | 6989339 |
| update: adolescent gynecology. | as adolescents develop their sexual identities they are at risk for acquiring sexually transmitted diseases, unwanted pregnancies, and cervical dysplasia. as physical growth and development progress during adolescence, the risk of developing dysmenoorhea or adverse effects from exposure to diethylstilbestrol increase. the pediatrician with a background in growth and development should be capable of recognizing these conditions and participating in their management. | 1980 | 6990360 |
| metronidazole inactivation by aerobes. | | 1980 | 6995421 |
| [evaluation of the usefulness of indirect immunofluorescence technic for serodiagnosis of trichomonas vaginitis]. | | 1980 | 6996038 |
| [differential diagnosis of "sterile leukocyturia"]. | | 1980 | 7002525 |
| three metronidazole-resistant strains of trichomonas vaginalis from the united states. | trichomonas vaginalis isolates were obtained in the united states from three women with trichomoniasis refractory to routine treatment with metronidazole. cure was obtained in these cases with increased dosage of metronidazole. in experimental mouse infections, all three strains showed a significantly (about 10 to 20 times) lower susceptibility to metronidazole than did a number of control strains. in vitro, the lowered susceptibility could be detected only in an aerobic assay but not in the rou ... | 1980 | 7004190 |
| the clinical and laboratory diagnosis of trichomonas vaginalis infection. | one hundred consecutive female patients attending an inner-city clinic for treatment of sexually transmitted diseases were evaluated for the presence of trichomonas vaginalis by history, physical examination, 0.85% nacl wet mount, papanicolaou smear, and culture. of the 100 women, 54 were found to be harboring the parasite, as determined by one or more positive diagnostic tests. this prevalence corresponds with that reported previously. the information gained from the history (symptoms and phase ... | 1980 | 7006116 |
| inhibition of trichomonas vaginalis by fungi during associative growth. | in controlled studies of associative growth, candida albicans and torulopsis glabrata, but not candida parapsilosis, inhibited the proliferation and eventually the viability of trichomonas vaginalis. the inhibition patterns produced against the trichomonad by c. albicans or t. glabrata were observed with trichomonad-fungus inoculum ratios ranging from 230:1 to 1:100. the onset of inhibition of t. vaginalis by t. glabrata was immediate, whereas that of c. albicans began after incubation for 48 hr ... | 1980 | 7006117 |
| culture of seminal fluid in a fertility clinic. | to determine whether the culture of seminal fluid in a fertility clinic is of importance, bacterial cultures were obtained in a consecutive series of 96 patients. routine bacteriologic cultures were performed within 1 hour of collection. ureaplasma urealyticum (t-mycoplasma) cultures were also obtained in the last 31 of the patients in this series. of these 96 patients, 11% showed significant bacterial growth (greater than 10(4) colonies/ml) in the semen specimens, 8% in those patients with norm ... | 1981 | 7009221 |
| in vitro attraction of polymorphonuclear leucocytes by trichomonas vaginalis. | boyden chambers were used to investigate the attraction of polymorphonuclear leucocytes to t. vaginalis. chemotaxis to live organisms was demonstrated, and chemotaxis to t. vaginalis supernatant was shown to be concentration dependent. both chemokinesis and true chemotaxis characterized the response to supernatants. there was no chemotaxis to the supernatant after it had been heated to 60 c for 1 hr, or to the supernatant from formalin-fixed t. vaginalis. the chemotactic factor in the supernatan ... | 1980 | 7012294 |
| igg antibody to giardia lamblia detected by enzyme-linked immunosorbent assay. | a sensitive, reproducible enzyme-linked immunosorbent assay using unfixed, intact giardia lamblia trophozoites as antigen is described. employing this assay, we demonstrated that 81% of 59 symptomatic giardiasis patients and 12% of 17 uninfected control subjects had circulating igg antibodies to g. lamblia. eleven out of 15 patients tested serially had detectable antibody from 2 wk to 15 mo after therapy for acute infection. the prevalence of antibody in 197 unselected individuals in the washing ... | 1981 | 7014351 |
| urologic aspects of trichomoniasis. | | 1981 | 7014514 |
| a preliminary study of antibodies against trichomonas vaginalis infection using the i.f.a.t. | | 1981 | 7028881 |
| vaginitis associated with vaginal malodour. | in two general practices in perth, western australia, the most common microbiological causes of vaginal discomfort in 368 patients were candida albicans. gardnerella (haemophilus) vaginalis, trichomonas vaginalis and bacteroides fragilis. amongst patients with abnormal vaginal odour, with or without vaginitis, the most common cause of odour was g. vaginalis. the writers advocate that heavy growths of group b streptococci, escherichia coli, and enterococci should be considered to be the possible ... | 1981 | 7029228 |
| [indirect immunofluorescence technic in the serodiagnosis of trichomonas infections]. | | 1981 | 7036229 |
| [evaluation of the methods used in microbiological diagnosis of mycoses and trichomonas infections of the genital tract]. | | 1981 | 7039140 |
| human host response to giardia lamblia. i. spontaneous killing by mononuclear leukocytes in vitro. | to understand host resistance to giardia lamblia infection, we investigated the capacity of human peripheral blood effector cells to kill g. lamblia trophozoites. peripheral blood was obtained from 12 healthy, uninfected individuals without detectable igg anti-g. lamblia antibody or known exposure to g. lamblia. isolated mononuclear leukocytes (mnl), granulocytes, lymphocytes, and monocytes were cultured 16 hr with g. lamblia that had been pulsed with (3h)tdr while in log growth. mnl from all 12 ... | 1982 | 7057036 |
| biochemical diagnosis of vaginitis: determination of diamines in vaginal fluid. | to assess correlations between the content of the diamines putrescine and cadaverine in vaginal fluid and the clinical manifestations of vaginitis, a rapid procedure for the determination of diamines has been developed. the procedure involves thin-layer chromatography of the dansylated vaginal washings; then the fluorescence of dansyl diamines is compared with that of dansyl alanine. for 520 college women, the result of the test for diamines was positive in 173 (88%) of 197 women with nonspecifi ... | 1982 | 7061879 |
| single dose treatment of trichomoniasis. | oral treatment for trichomonas vaginalis infection is now well established. in a previous paper, we established the value of a high single dose regimen of metronidazole for this condition by demonstrating its efficacy in a double-blind controlled study. tinidazole is another accepted trichomonacide. by means of a single-blind controlled trial, we demonstrate that a 2 g single dose of tinidazole is as effective as a 2 g single dose metronidazole in the treatment of vaginal trichomoniasis. the cur ... | 1982 | 7067925 |
| vulvovaginitis in premenarcheal girls: clinical features and diagnostic evaluation. | fifty-four premenarcheal patients (median age 5.8 years) with symptoms or signs of vulvovaginitis were studied, and the results of cultures of vaginal secretions were compared with those from an age-matched control group. vaginal discharge was found on examination in 24 of 42 patients with a complaint of discharge, and in two of 12 patients without a complaint of discharge. convincing evidence of bacterial or monilial infection was found in 14 of the 26 patients with discharge on examination, bu ... | 1982 | 7099784 |
| urogenital involvements and musculoskeletal complaints in women. an interview study and clinical investigation with special reference to chlamydial infections. | to study the correlation of urogenital involvements and musculoskeletal complaints in females, 311 randomly selected women, aged 15 to 54, were interviewed. in addition, clinical gynecological examination including isolation and serology of chlamydia trachomatis (ct) was performed for 30 consecutive volunteers. a history of musculoskeletal complaints occurred in 218 (70.1%) and a history of urogenital involvements in 244 (78.5%) of the 311 women. the number of urogenital involvements in 218 fema ... | 1982 | 7123176 |
| chlamydia trachomatis infections in women with urogenital symptoms. | chlamydia trachomatis was isolated from 30 to 100 women attending a family physician's office with dysuria, frequency or vaginal discharge, compared with 2 of 30 asymptomatic women. multiple infections were common: c. trachomatis coexisted with gardnerella vaginalis, candida albicans, trichomonas vaginalis or a bacterial cause of urinary tract infection in 15 patients. c. trachomatis was isolated alone from 15 symptomatic women. the source of the positive culture was not always the site of sympt ... | 1982 | 7139448 |
| pharmacokinetics of tinidazole in male and female subjects. | tinidazole is a potent nitroimidazole compound active against, and used to treat, trichomonas vaginalis infections in males and females. speculation exists in the literature that observed differences in tinidazole plasma concentrations between males and females may be due to sex-mediated pharmacokinetic differences. to investigate this phenomenon, a study was designed to determine the pharmacokinetics of tinidazole in male and female subjects. six male and six female volunteers were each adminis ... | 1982 | 7161410 |
| clinic diagnosis of anaerobic vaginosis (non-specific vaginitis). a practical guide. | anaerobic vaginosis (non-specific vaginitis) can be readily diagnosed at the time of first attendance without recourse to expensive and time-consuming laboratory investigations. diagnosis is based on careful history-taking, clinical examination, and simple investigations in the clinic. although the presence of a malodorous vaginal discharge and the finding of clue cells on microscopy (in the absence of trichomonas vaginalis) are sufficient for the diagnosis, a positive amine test and a vaginal p ... | 1982 | 7171981 |
| the incidence of selected vaginal infections among pregnant urban blacks. | a total of 232 black antenatal patients was assessed in a cross-sectional study and a total of 80 in a longitudinal study. trichomonas vaginalis infection occurred almost twice as frequently as candida albicans infection. neisseria gonorrhoeae infection was present in 10% of patients, and mixed infections were present in 34% of patients. | 1981 | 7233301 |
| oral contraceptive use and prevalence of infection with chlamydia trachomatis in women. | one thousand eight non-pregnant women aged 16-34 years, presenting for the first time at a clinic for sexually transmitted diseases (std), were examined and screened for infection with chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis, and candida species. the respective prevalence rates were 21.1%, 20.7%, 13.4%, and 27.8%. isolation rates for c trachomatis, either occurring alone or in association with other genital infections, were significantly greater in women using oral co ... | 1981 | 7237082 |
| intestinal and urogenital flagellates. | although the human alimentary and urogenital tracts are parasitized by seven species of flagellate protozoa [115], only two, giardia lamblia and trichomonas vaginalis, are generally considered to be pathogens. this review, therefore, concentrates on these organisms and in particular on the experimental and clinical chemotherapy of trichomoniasis and giardiasis. due to the limited space and the availability of excellent recently published reviews, topics such as life cycles, epidemiology, prevale ... | 1981 | 7259131 |
| some reactions of 1,4-dihydropyridines with organic azides. synthesis of 2,7-diazabicyclo[4.1.0]hept-3-enes with analgesic and antiprotozoal activity. | the 1,3-dipolar cycloaddition reaction of 1,4-dihydropyridines, 2, with organic azides, 3, afford 2,7-diazabicyclo[4.1.0]hept-3-enes, 4, which exhibit significant analgesic and antiprotozoal activities. the most active analgesics, 4a and 4c, were more potent than aspirin or dextropropoxyphene. diazabicyclo[4.1.0]hept-3-enes 4a-e exert potent antiprotozoal activity, inhibiting growth of trichomonas vaginalis at concentrations of less than 10 micrograms/ml of medium. the broad spectrum pharmacolog ... | 1981 | 7265132 |
| nitroimidazoles in the canine prostate, vagina, and urethra. | diffusion of metronidazole and tinidazole in canine prostatic secretion was studied and compared to the diffusion of metronidazole into the canine vagina. this particular comparison was made because prostatic secretion represents an acidic environment in contrast to the canine vagina which has a basic ph. metronidazole reached significantly higher concentrations in the prostatic secretion (ps) than in plasma (p). no differences were found in the concentrations of tinidazole in p and ps. plasma a ... | 1981 | 7279813 |
| [diffusion of trichomonas vaginalis and of several species of candida in a sample of the female population of bologna as related to the principal endogenous and exogenous factors]. | in this work, the authors report the results of an epidemiological study on trichomonas vaginalis and candida spp. frequency in a sample of the adult female population in bologna. they also studied the influence exerted by some epidemiological variables such as age, profession, civil status, educational status, use of specific products for feminine hygiene, contraceptive usage, and sexual habits. some interesting correlations were observed. (author's modified) | 1981 | 7346774 |
| [cytomorphological changes and intensity of inflammation in cervico-vaginal smears containing trichomonas vaginalis, candida albicans, and leptothrix vaginalis]. | | 1980 | 7412371 |
| diagnosis and treatment of vaginal discharge in pregnancy. | a total of 232 pregnant black antenatal patients was examined to determine the clinical features of vaginal infection. there was no correlation between the symptoms and the infection. the finding of a 'strawberry' vagina was specific for trichomonas vaginalis infection, for which a single dose of 1 600 mg metronidazole (flagyl) was found to be a highly effective form of therapy. | 1980 | 7423322 |
| trichomonacidal activity of human polymorphonuclear neutrophils: killing by disruption and fragmentation. | polymorphonuclear neutrophils (pmns) were shown to kill trichomonas vaginalis in vitro; 10(2)-10(3) trichomonads were incubated with 3 x 10(6) pmns on tissue culture plates, and surviving organisms were enumerated in pour plates. after 60 min of aerobic incubation at 37 c, 100% (+/- 0) of the trichomonads had been killed, and nitroblue tetrazolium was reduced at the interface between the pmns and trichomonads. the importance of oxidative microbicidal systems was confirmed by the observations tha ... | 1980 | 7441017 |
| characterization of double-stranded rna satellites associated with the trichomonas vaginalis virus. | three small and distinct satellite double-stranded rnas (dsrnas) denoted s1, s1', and s2 were recently described for a trichomonas vaginalis isolate harboring a dsrna virus. since characterization of these satellite dsrnas might provide insight into the virus replication cycle and virus-host interactions, full-length cdnas to s1 and s1' dsrnas were synthesized and sequenced. s1 dsrna has 688 bp, and s1' dsrna has 616 bp. a 228-bp open reading frame that begins at nucleotide 37 was detected on a ... | 1995 | 7474105 |
| cloning and molecular characterization of two genes encoding adhesion proteins involved in trichomonas vaginalis cytoadherence. | cytoadherence to the vaginal epithelium is a critical step in infection by the eukaryotic flagellate trichomonas vaginalis. four trichomonad surface proteins (ap65, ap51, ap33 and ap23) mediate cytoadherence. the cdna encoding the ap65 adhesin was isolated from a phagemid cdna expression library by screening with antiserum and monoclonal antibody (mab) raised against the purified trichomonad ap65 protein. two clones, f11.2 and f11.5, coded for immuno-crossreactive recombinant proteins that posse ... | 1995 | 7476210 |
| analysis for adhesins and specific cytoadhesion of trichomonas vaginalis. | | 1995 | 7476404 |
| screening for chlamydia trachomatis infection in pregnant women in martinique. | to determine the prevalence of chlamydia trachomatis urogenital infection and to identify behavioral, demographic, and clinical factors associated with the infection in pregnant women in martinique. | 1995 | 7482104 |
| spectrum of genital human papillomavirus infection in a female adolescent population. | human papillomavirus infection is a sexually transmitted disease associated with cervical dysplasia and carcinoma. | 1995 | 7482107 |
| male urethritis with and without discharge: a clinical and microbiological study. | the definition of male urethritis in the absence of urethral discharge has not been well established. the sensitivity of urethral swabs and first-catch urine is controversial. | 1995 | 7482108 |
| the preterm prediction study: significance of vaginal infections. national institute of child health and human development maternal-fetal medicine units network. | our purpose was to evaluate the association of bacterial vaginosis, trichomonas vaginitis, and monilial vaginitis with spontaneous preterm birth at < 35 weeks 0 days. | 1995 | 7485327 |
| pharmacodynamics of metronidazole determined by a time-kill assay for trichomonas vaginalis. | the pharmacodynamic effects of metronidazole on trichomonas vaginalis have been poorly characterized. the present in vitro study was performed to characterize the relationship between killing of trichomonads and metronidazole exposure (metronidazole concentration and time of exposure). five laboratory strains and five recent clinical isolates of t. vaginalis were studied. the minimum lethal concentrations (mlcs) of metronidazole for the strains ranged from 0.8 to 25 micrograms/ml under anaerobic ... | 1995 | 7486930 |