| gamma-ray mutagenesis in bacteriophage t4 is not enhanced by oxygen. | as in the induction of r mutants in bacteriophage t4 by gamma-rays, the radiation-induced reversion of t4 amber mutants to wild-type was found to depend on the product of the dna-repair gene x of the phage. neither the efficiency of induction of r mutants nor the efficiency of reversion of ambers was enhanced by the presence of oxygen during irradiation. t4 differed in this respect from phage t7, for which no indication has been found that gamma-ray mutagenesis results from error-prone repair of ... | 1979 | 481435 |
| amenorrhea secondary to voluntary weight loss. | obese patients who voluntarily reduce to a normal weight may develop secondary amenorrhea. six young women who dieted to lose from 13 to 50 pounds, including four from an obese weight, were evaluated because of absent cervical mucus ferning, hypoestrogenic vaginal smears, and failure to have withdrawal menses from a progestogen. serum fsh values were normal in all, while four had normal serum lh and two had low serum lh levels. t4 and/or t3 uptake was normal in all. the pituitary-adrenal axis wa ... | 1979 | 482981 |
| epidural analgesia inhibits the renin and aldosterone response to surgery. | renin activity and aldosterone concentration in plasma and excretion of sodium and potassium in urine were measured during a period of 24 hours in 12 patients undergoing hysterectomy under general anaesthesia or epidural analgesia. analgesia extended from t4 to s5 and was effective throughout the study. the normal stress-induced increase in plasma renin activity and aldosterone was inhibited by epidural analgesia. urinary excretion of potassium was significantly lower in the epidural group, but ... | 1979 | 484183 |
| non-selective and selective beta-1-adrenoceptor blocking agents in the treatment of hyperthyroidism. | treatment for one month with propranolol or atenolol, a selective beta-1-adrenoceptor blocking agent, was evaluated in 20 hyperthyroid patients. the patients improved to the same extent on either drug, as shown by a clinical diagnostic index. basal metabolic rate decreased by 11% during both treatments, while it was unchanged in seven untreated hyperthyroid controls. thyroxine concentration did not change during any treatment. during propranolol treatment t3 decreased from 4.6 to 3.9 nmol/l, whi ... | 1979 | 484256 |
| serum thyroid hormone levels in patients with liver disease. | levels of serum triiodothyronine (t3), reverse triiodothyronine (rt3), and thyroxine (t4) were determined in 29 patients with alcoholic cirrhosis, seven patients with acute hepatitis, and 14 control patients hospitalized for chronic disease. serum t3 levels were decreased significantly and serum rt3 levels increased significantly in the patients with alcoholic cirrhosis. serum t3 and t4 levels were lower and rt3 levels higher in the cirrhotic patients who died within three months of the study co ... | 1979 | 485743 |
| effect of epidural analgesia on metabolic profiles during and after surgery. | blood concentrations of glucose, lactate, alanine, free fatty acids, glycerol and 3-hydroxybutyrate were measured during 24 h in 12 females undergoing elective hysterectomy under either general anaesthesia or epidural analgesia extending from t4 to s5. the results showed that the peroperative and immediate postoperative metabolic profiles in the group receiving general anaesthesia reflected substrate mobilization (increased glucose, lactate, 3-hydroxybutyrate), and that epidural analgesia blocke ... | 1979 | 486911 |
| congenital goitre and hypothyroidism with impaired iodide organification and high thyroid peroxidase concentration. | a sibship of thirteen subjects whose parents were first cousins was studied for a defect in thyroid hormone synthesis. five sibs were goitrous and had congenital hypothyroidism. all but one showed a positive perchlorate discharge test (pdt). three other subjects were goitrous and euthyroid (one with a positive pdt), and the remaining five sibs were euthyroid with a presumably normal thyroid. however, an abnormally exaggerated tsh response to trh was observed not only in the hypothyroid patients ... | 1979 | 487612 |
| [solid phase radioimmunoassay for thyroxine (t4) (author's transl)]. | | 1979 | 487628 |
| triiodothyronine (t3), thyroxine (t4), and thyrotropin (tsh) in childhood. | | 1979 | 487865 |
| radiochromium distribution in hypophysectomized and adrenalectomized rats. | the effects of hypophyseal and adrenal ablation (hypox, adx) on trivalent radiochromium (51cr) distribution and of gh and t4 replacement in hypox rats were determined. hypophysectomy increased body retention of 51cr by 20--35%, and hormonal replacement restored body retention to normal. serum 51cr was increased 300--800%, resulting in depressed tissue to serum 51cr ratios. gh replacement partially restored the 51cr distribution abnormalities in hypox rats to normal. the combination of t4 with gh ... | 1979 | 488009 |
| kinetic and thermodynamic studies of antigen-antibody interactions in heterogeneous reaction phases--i. l-thyroxine (t4) with specific antibody immobilized on controlled pore glass. | | 1979 | 489052 |
| investigations on myelination in vitro. regulation by thyroid hormone in cultures of dissociated brain cells from embryonic mice. | cultures of dissociated brain cells from embryonic mice were used to study the influence of thyroid hormone on myelination in vitro. synthesis of myelin-associated lipids such as cerebrosides and sulfatides was used as an index for myelination. an experimental design, in which the cells were grown on medium containing serum from a thyroidectomized calf, was employed to demonstrate the direct effect of l-3,5,3'-triiodothyronine (t3y on the biosynthesis of myelin lipids. the cells grown in the pre ... | 1979 | 489534 |
| serum 3,5,3'-triiodothyronine and 3,3',5'-triiodothyronine concentrations during acute heat load. | to determine the changes in thyroid hormone metabolism during short periods of exposure to heat, 30 euthyroid healthy male volunteers (aged 23--40 yr) were placed in a climatic chamber for 2 h (35 c, 50% relative humidity). the subjects were at complete rest during the first hour and performed light work (40 watts) during the second hour. blood samples for t4, t3 and rt3 were drawn at 0, 60, and 120 min. rectal temperature and heart rate were monitored continuously. no significant changes in t4, ... | 1979 | 489710 |
| a comparison of plasma protein changes induced by danazol, pregnancy, and estrogens. | analysis of 25 plasma proteins was performed on blood drawn from 7 females before and during treatment with danazol. this steroid was found to induce a pattern of plasma protein changes similar to but not identical with that of other 17 alpha-alkylated anabolic steroids. for comparison, the same 25 plasma proteins were analyzed in blood from pregnant women in their third trimester, when the estrogen influence on plasma protein synthesis is most pronounced. five major types of response were found ... | 1979 | 489712 |
| measurement of free thyroid hormones in serum by column adsorption chromatography and radioimmunoassay. | a new method for the assay of free thyroid hormones in human serum is described. this method is based on a chromatographic adsorption process of thyroid hormones onto a sephadex lh-20 resin column. protein fractions are eliminated by washing columns, adsorbed hormones are eluted with methanol and determined by radioimmunoassay. it was demonstrated that under the experimental conditions adopted the presence of the resin r does not significantly change the free hormone level in the serum, and the ... | 1979 | 489914 |
| prolonged intravenous infusion of labelled iodocompounds in the rat: [125i]iodide metabolism and effects of moderate dietary iodine deficiency. | radio-iodide was administered by prolonged continuous intravenous infusion to rats maintained under iodine-replete conditions and in moderate iodine deficiency. a close approximation to equilibrium labelling was thereby achieved. labelled iodocompounds extracted from various tissues were analysed by thin-layer chromatography. moderate iodine deficiency resulted in a slight increase in the ratio of mono-iodotyrosine to di-iodotyrosine in the thyroid. no change in the ratio of tri-iodothyronine (t ... | 1979 | 490078 |
| prolonged intravenous infusion of labelled iodocompounds in the rat: [125i]thyroxine and [125i]tri-iodothyronine metabolism and extrathyroidal conversion of thyroxine to tri-iodothyronine. | extrathyroidal tissues of the rat were labelled to steady state by prolonged continuous intravenous infusion of 125i-labelled thyroxine (t4) or tri-iodothyronine (t3). labelled iodocompounds extracted from various tissues were analysed by thin-layer chromatography. signifficant amounts of labelled t3 were found in all tissues examined after infusion of [125i]t4, confirming that conversion of t4 to t3 occurs in extrathyroidal tissues of the rat. faecal excretion of labelled t3 after [125i]t4 infu ... | 1979 | 490079 |
| on the purpose of selective innervation of guinea-pig superior cervical ganglion cells. | preganglionic axons arising from different levels of the mammalian spinal cord make preferential connexions with different classes of superior cervical ganglion cells (langley, 1892, 1900; njå & purves, 1977a). for example, preganglionic axons from the first thoracic segment (t1) make relatively strong connexions with ganglion cells activating end-organs of the eye; conversely, axons arising from t4 selectively innervate ganglion cells projecting to the ear. in the present work we have asked whe ... | 1979 | 490406 |
| [synthesis, secretion, and metabolism of t4 and t3]. | | 1979 | 491209 |
| serum t4, t3 and reverse t3 in ethanol fed rats. | | 1979 | 491838 |
| serum thyroxine, free t4, triiodothyronine, and reverse-t3 in diphenylhydantoin-treated patients. | | 1979 | 491974 |
| evidence for a partial rna transcript of the small circular component of kinetoplast dna of crithidia acanthocephali. | the major component of kinetoplast dna (kdna) in the protozoan crithidia acanthocephali is an association of approximately 27,000, 0.8 micrometers (1.58 x 10(6) dalton) circular molecules apparently held together in a particular structural configuration by topological interlocking. we have carried out hybridization experiments between kdna samples containing one or the other of the two complementary (h and l) strands of purified 0.8 micrometers molecules derived from mechanically disrupted assoc ... | 1979 | 493124 |
| [changes of t3 and t4 plasma levels in patients with hepatic cirrhosis]. | | 1979 | 493580 |
| subclinical hypothyroidism in addison's disease. | fourteen patients with idiopathic addison's disease (iad) were studied in order to detect a possible subclinical hypothyroid state. all were clinically euthyroid with normal serum thyroxine (t4) and serum 3,5',5'-triiodothyronine (t3). eleven had circulating thyroid microsomal antibodies in blood. the mean basal serum tsh was significantly higher than that of the control group but only three patients had values above the upper normal range. the mean value of serum t4 was decreased as compared to ... | 1979 | 494979 |
| effect of endogenous thyroid stimulating hormone levels on the secretion of thyroid hormones in man. | the effect of endogenous thyroid stimulating hormone (tsh) on the thyroid secretion of triiodothyronine (t3) and thyroxine (t4) was evaluated by serial determinations of serum t3. t4 and tsh concentrations in the following groups of patients: a) three patients submitted to surgical removal of a solitary, autonomous thyroid nodule which had completely inhibited the extranodular tissue; b) five subjects, with the same disease, in whom functional recovery of the extranodular tissue was induced by i ... | 1979 | 494987 |
| on the mechanism of central effect of thyroxine on body temperature in dogs. | the effect of intraventricular injection of thyroxine 1 microgram/animal on body temperature was studied in dogs under resting conditions: at normal ambient temperature, at high ambient temperature (35 degrees c) and during administration of pyrogen. besides, changes in body temperature were elucidated in dogs performing physical exercise following i.v. t4 injection in the same dose. thyroxine exerted its central action on body temperature only in dogs performing physical exercise. | 1979 | 495147 |
| re-evaluation of a possible high incidence of hypertension in hypothyroid patients. | in an attempt to re-evaluate a possible high incidence of hypertension in hypothyroid patients, blood pressure was measured in 38 slightly hypothyroid patients, in 17 moderate hypothyroid patients, and in 26 severe hypothyroid patients. the data were then compared with the findings in 73 known euthyroid subjects and in 1,601 possibly euthyroid subjects. blood pressure and incidence of hypertension increased progressively with age in known euthyroid subjects and in possibly euthyroid subjects. si ... | 1979 | 495417 |
| impeded cerebellar development and reduced serum thyroxine levels associated with fetal alcohol intoxication. | pregnant albino rats were placed on a complete liquid diet (ensure) containing either 9% ethanol or an isocaloric amount of sucrose between the third and twentieth day of gestation. the pups born to these rats were sacrificed either day 11 or day 14 postnatum and morphometrical, histological and biochemical analyses were done on their cerebellums and cerebrums. pups that were exposed to ethanol in utero had significantly smaller body weights, cerebrums and cerebellums than pair-fed controls. the ... | 1979 | 497836 |
| the combined radioimmunoassay of triiodothyronine and thyroxine. | an ria method for the concurrent determination of serum triiodothyronine (t3) and thyroxine (t4) is described. the extraction of the hormones from serum and competitive binding reactions using specific t3 and t4 antisera were conducted in sequence in a single sephadex column. precision studies resulted in average interassay relative standard deviations for t3 and t4 of 17 and 9.5%, respectively. the assay also exhibited satisfactory recovery and correlation with reference procedures (t3: y = 0.8 ... | 1979 | 498530 |
| presence of triiodothyronine, no detectable thyroxine and reverse triiodothyronine in human milk. | thyroxine (t4), triiodothyronine (t3) and reverse triodothyronine (rt3) concentrations in human milk were measured by radioimmunoassay in 114 samples obtained from 1 week to 8 months postpartum. several assay systems applied for the determination of serum thyroid hormone concentration were proved to be unsuitable for human milk, and the method of separating free and antibody-bound hormone by polyethylene glycol was also inappropriate for milk specimens, which tended to give a falsely high value. ... | 1979 | 499092 |
| transient hypothyroidism associated with prematurity, sepsis, and respiratory distress. | serial tsh and t4 determinations were performed in sixty neonates admitted to our hospital for neonatal intensive care within a period of three months. seven patients (12%) showed transient hypothyroidism on the basis of low t4 and high tsh values. only one of these patients, who had meconium aspiration and pneumonia, did not have the respiratory distress syndrome. in addition, 4 of these patients had sepsis. all of the patients were born before 37 gestational weeks and had birth weights under 2 ... | 1979 | 499263 |
| [triiodothyronine (t3) 3,3',5'-l reverse triiodothyronine (rt3), thyroxine (t4) and free thyroxine index (ft4-i) levels in the blood serum of pregnant women]. | | 1979 | 499891 |
| histochemical study on the localization of glucose-6-phosphate dehydrogenase induced by androgen or thyroxine in the convoluted tubules of mouse submandibular gland. | the effects of 5 alpha-dihydrotestosterone (dht) and thyroxine (t4) on glucose-6-phosphate dehydrogenase (g-6-pdh) activity in mouse submandibular gland were investigated histochemically. a strong positive histochemical reaction for g-6-pdh was observed in the excretory ducts of untreated male and female mice, with a slight reaction in the basal portion of the convoluted tubules (striated ducts) of males. administration of dht to female mice increased g-6-pdh activity specifically in the convolu ... | 1979 | 500409 |
| hormonal stimulation of erythropoietin production and erythropoiesis in anephric sheep fetuses. | the effect of testosterone (dt) and thyroxin (l-t4) on erythropoiesis and erythropoietin (ep) production was studied in control and nephrectomized sheep fetuses beginning at about 100 d of gestation. fetuses were given injections of either 1.2 mg/d x 13 of l-t4, 12 mg, once every 5 d x 3 of dt or the vehicle alone. fetal plasma samples for ep determinations were obtained before and at intervals after the start of the treatment. reticulocyte and hematocrit levels, and the percent erythrocyte-59fe ... | 1979 | 500805 |
| cleavage map of bacteriophage t4 cytosine-containing dna by sequence-specific endonucleases sali and kpni. | cytosine-containing t4 dna from endoii- endoiv- dctpase- alc2 phage grown in a sup+ rb- mb- host is cleaved by endo r.ecori and endo r.hindiii to greater than 40 fragments and by endo r.sali and endo r.kpni to 8 and 6 fragments, respectively. the latter two fragment sets have been correlated to each other to produce a cleavage map of the genome. the sum of the molecular weights of the fragments calculated from electrophoretic mobility in agarose gels yields a genome molecular weight for cytosine ... | 1979 | 501794 |
| [problems of radioimmunoassay of t3, t4 and tsh (author's transl)]. | | 1979 | 502033 |
| [fundamental study for t3-rsu, t3, t4 and tsh measurement method (author's transl)]. | | 1979 | 502034 |
| the course of untreated mild t3 toxicosis. | a selected group of 12 patients with mild t3 toxicosis, has been assessed without treatment during a period of from seven to 38 months. progression to typical hyperthyroidism with combined t4 and t3 excess occurred in one case of solitary toxic adenoma, while a spontaneous remission with return of the thyrotropin response to thyrotropin-releasing hormone occurred in one patient with a diffuse goitre. the other 10 patients showed persistence of isolated high levels of t3 without clinical or bioch ... | 1979 | 502952 |
| [tsh, t3 and t4 serum concentration in children living in two endemic goiter areas (author's transl)]. | | 1979 | 504836 |
| [further investigations concerning the reaction between haptoglobin and t4-antigen-carrying streptocci (author's transl)]. | the median level of haptoglobin types 2-2 and 2-1 was found to be proportional to the agglutination titer of t4 antigen-carrying streptococci (fig. 1). this relationship need not exist in individual sera since, as seen from table 1, high agglutination titers may be caused by sera with low levels of haptoglobin. thus the agglutination reaction might depend not only on the quantity of haptoglobin but also on other factor(s) (at least in individual serum samples). - on the other hand, different agg ... | 1979 | 506546 |
| variations in plasma thyroxine concentrations throughout one year in penned sheep on a uniform feed intake. | plasma total thyroxine (t4) concentrations were measured by radioimmunoassay throughout one year in 10 sheep maintained indoors under natural light and consuming a constant amount of feed. plasma t4 concentrations varied throughout the year, the highest and lowest values occurring in the spring and autumn months respectively. the mean of all observations was 5.4 +/- 0.1 microgram/dl. the changes observed did not appear to correlate with changes in ambient temperature, day length or with reported ... | 1979 | 508210 |
| the effect of propylthiouracil on thyroid-stimulating hormone-induced alterations in iodothyronine secretion from perfused dog thyroids. | the aim of this study was to see whether the inhibitory effect of propylthiouracil on thyroidal secretion of 3,5,3'-triiodothyronine (t3) and 3,3',5'-triiodothyronine (rt3) could be reproduced in intensively stimulated thyroids, and to elucidate whether an increase in the fractional deiodination of thyroxine (t4) to t3 and rt3 during iodothyronine secretion might be responsible for the transient fall in the t4/t3 and t4/rt3 ratios in thyroid secretion seen in the early phase after stimulation of ... | 1979 | 508809 |
| dissociated thyroxine, triiodothyronine and reverse triiodothyronine levels in patients with familial goitre due to iodide organification defects. | the thyroid function of patients with three different types of organification defect was studied. all patients were characterized by a high thyroidal 131i uptake and a positive perchlorate discharge. patients with pendred's syndrome who had goitre and congenital nerve deafness were mostly euthyroid with normal circulating thyroid hormone levels. only two of them had compensated euthyroidism with elevated total t3, high basal tsh and delayed return to basal value with trh. the patients who were e ... | 1979 | 509742 |
| molecular conformation of thyroid hormones: structure and binding interactions of thyroxine. | in an accurately determined x-ray diffraction study of the thyroid hormone thyroxine (t4), the two independent conformations in the crystal lattice show significant differences in the outer phenyl ring geometry when compared with that of 3,5,3'-triiodothyronine (t3). the major differences between the t4 and t3 structures are a shortened c4'-o4' bond, contraction of the c3'-c4'-c5' angle and an increase in the c3' and c5' angles of t4. these changes can be correlated with the difference in acidit ... | 1979 | 510217 |
| the distal half of the tail fibre of bacteriophage t4. rigidly linked domains and cross-beta structure. | | 1979 | 513135 |
| rega protein of bacteriophage t4d: identification, schedule of synthesis, and autogenous regulation. | proteins labeled with 14c-amino acids after infection of escherichia coli b by t4 phage were examined by electrophoresis in the presence of sodium dodecyl sulfate. four rega mutants (rega1, rega8, rega11, and rega15) failed to make a protein having a molecular weight of about 12,000, whereas mutant rega9 did make such a protein; rega15 produced a new, apparently smaller protein that was presumably a nonsense fragment, whereas rega11 produced a new, apparently larger protein. we conclude that the ... | 1979 | 513206 |
| [functional activity of the hypophyseal-thyroid system in oncological patients]. | studies of the hypophyseal-thyroid system in patients with cancer of the lung, stomach, mammary gland have revealed similar changes, manifested in the increased tth concentration with simultaneous fall in the t3 and t4 content with the resultant increase of tth/t3 and ttj/t4 coefficients. the changes observed are characteristic of oncological patients only and may be used for diagnostic purposes. | 1979 | 516575 |
| effects of three-day oral cholecystography on serum iodothyronines and tsh concentrations: comparison of the effects among some cholecystographic agents and the effects of iopanoic acid on the pituitary-thyroid axis. | the effects of repeated doses of oral cholecystographic agents on serum thyroxine (t4), 3,3',5-triiodothyronine (t3), 3,3',5'-triiodothyronine (rt3) and thyrotrophin (tsh) concentrations were studied in 37 euthyroid male subjects. iobenzamic acid, tyropanoic acid, iopanoic acid, and ipodate sodium, in a dosage of 3 g for 3 days, respectively, induced a significant decrease in serum t3 and an increase in rt3 within 24 h after the initial dose, followed by an increase in tsh and a slight increase ... | 1979 | 517049 |
| preparation of thyroxine (t4) and triiodothyroxine (t3) free serum avoiding charcoal fines. | | 1979 | 517987 |
| [in vivo regulation by calcium of the thyroidal iodine metabolism and its modulation by sodium, in the rat (author's transl)]. | in vivo experiments, in the rat, using diets deficient in calcium, or sodium or both ions, proved these cations to regulate the thyroidal iodine metabolism. calcium enhanced iodine entry into the thyroid and the intrathyroidal iodine and t4 pools. t4 level in serum was also increased by calcium. sodium enhanced iodine entry and secretion. the two cations have local regulatory functions on the thyroid gland and do not affect tsh levels in serum and the hypophysis. the effects of calcium and sodiu ... | 1979 | 518018 |
| [immunoreactive somatostatin in rat hypophysial portal blood (author's transl)]. | somatostatin levels have been determined by radioimmunoassay in hypophysial portal blood of pentobarbital-anesthetized male rats. in euthyroid rats, the mean level was 158 +/- 27 pg/ml (n = 8); somatostatin was undetectable (less than 30 pg/ml) in systemic blood of these rats. thyroidectomy and excess of t4 did not modify the levels of somatostatin in hypophysial portal blood. | 1979 | 518025 |
| [neonatal screening for hypothyroidism by simultaneous determination of t4 and tsh on filter paper (author's transl)]. | a simultaneous determination of t4 and tsh has been done on 48 000 new borns since january 1st of 1977 in the midi-pyrénées district. 15 cases of hypothyroidism have been detected, an incidence of 1/3 200 new borns. tsh values always were above 80 microu/ml; t4 values are under m-2 sigma in 11 cases, normal in 2 cases (8,8 and 9 micrograms/dl) and between -1 and - 2 sigma in 2 cases. a thyroid scanning with 123 odine or 99 tech, has shown the absence of thyroid in 6 cases, an ectopic gland in 7 ... | 1979 | 518030 |
| [problems encountered during intensive routine scale performace of paper t4 and tsh radioimmunoassays (author's transl)]. | high sensitivity attained in radioimmunoassays explains the important role played by specialized laboratories as screening partners for early neonatal hypothyroidism detection. in this paper, the author tries to point out optimal technical conditions to be followed while performing at routine scale t4 and tsh paper immunoassays choice of filter paper, blood collection and storage, assay, quality control, assay mecanization, computer calculation of results). | 1979 | 518031 |
| influence of age on the endocrine-metabolic response to surgery. | the pathogenesis of the increased operative risk in elderly patients is unknown. from a theoretical point of view, a change in endocrine-metabolic response might be involved. in the present study, a battery of hormonal and metabolic variables were measured in eight young and eight elderly healthy males undergoing elective inguinal hernial repair under general anesthesia. blood was drawn before induction of anesthesia, at skin incision, and one, two, and six hours after skin incision. the finding ... | 1979 | 518178 |
| energy cost of ambulation in paraplegic patients using craig-scott braces. | energy metabolism data were collected in a series of 8 male paraplegic patients with neurologically complete spinal cord lesions between t4 and t12 (1 patient had complete motor paralysis with incomplete sensory function). energy costs were measured at the subject's seated basal rate (mean = 17.12cal/min/kg) and during 2 separate trials at ambulation using craig-scott braces. the rates of ambulation reflected the patient's perceived comfortable rate and ranged from 2.2 to 44.8m/min. (mean = 14m/ ... | 1979 | 518268 |
| [fundamental and clinical evaluation of spac t4 radioimmunoassay kit (author's transl)]. | | 1979 | 519888 |
| effect of thyroxine treatment on metabolic responses to a single insulin injection. | metabolic responses to a single i.v. injection of cristalline insulin (0.2 i.u./kg b.w.) were compared in control and t4-treated dogs both at rest and after prolonged physical exercise. the post-insulin decrease in blood glucose was significantly correlated with the pre-insulin bg concentration. thus, the insulin-induced fall of bg was greatest in t4-treated dogs at rest, in which significantly higher bg levels were found in comparison with controls, and smallest in the same dogs after exercise, ... | 1979 | 521011 |
| effect of neonatal administration of thyroxine on the rate of sebum production in rats. | newborn sprague-dawley rats of both sexes were treated with 28 micrograms thyroxine (t4) daily for the first week of life. at the age of 80 days, the secretion rate of sebum was measured from the amount of skin-surface lipids extractable by acetone and which had been produced during 2 days. treatment with such excess amounts of t4 during the early postnatal period significantly reduced the production of sebum in both male and female rats when compared with control rats and with rats deprived of ... | 1979 | 521736 |
| physiological changes in caged layers during a forced molt. 3. plasma thyroxine, plasma triiodothyronine, adrenal cholesterol, and total adrenal steroids. | the effects of forced molting on plasma levels of thyroxine (t4), triiodothyronine (t3), and adrenal cholesterol and total adrenal steroid content were studied. commercially available strains of single comb white leghorn (scwl) hens, reared and maintained under commercial conditions, were used in the three trials. the hens were moved to environmentally modified facilities prior to the forced molt which was accomplished by reducing daylength and by withdrawing feed and water. egg production cease ... | 1979 | 523391 |
| serum thyroxine, triiodothyronine and thyroid stimulating hormone after prolonged heavy exercise. | serum thyroxine (t4), triiodothyronine (t3) and thyroid stimulating hormone (tsh) was measured before, immediately after and on the following days after a 70 km cross-country ski race in two groups of ten well-trained men, one aged 21--29 years, taking 5.01--7.03 h, and one aged 51--57 years, taking 6.07--7.38 h. t4 was definitely increased immediately after the race, but fell to below the initial level on the following day and was not restored to the pre-race level until 4 days after the race. ... | 1979 | 523989 |
| labeling of lymphocyte surface immunoglobulins with t4 as marker for scanning electron microscopy. | the technique originally described by kumon et al. for the labeling of cell surface antigens under the sem has been adapted to the study of surface immunoglobulins on human lymphocytes. briefly, the peripheral blood lymphocytes are: 1) separated in a ficoll hypaque gradient, 2) rinsed with culture medium, 3) allowed to attach to plastic coverslips, 4) prefixed with 1% glutaraldehyde for 10 minutes, 5) incubated with goat anti-human immunoglobulins for 30 minutes at 24 degrees c, 6) rinsed, 7) in ... | 1979 | 524028 |
| [strategy and results in the treatment of squamous cell carcinoma of the anal canal. a review of 51 cases (author's transl)]. | in this retrospective study of 51 patients treated for squamous cell carcinoma of the anal canal some aspects of the natural history are touched upon. the authors also discuss their results and define their current therapeutic approach. it is a rare lesion; only 2-3% of all colorectal cancers with a predominance for women (4 to 1) and of 2 histological varieties. the epidermoid type (74%) is made more prevalent though the basal layer type (26%). the prognosis is very poor once the stage t, is pa ... | 1979 | 525165 |
| serum thyroxine (t4) and triiodothyronine (t3) uptake values in normal adult cats as determined by radioimmunoassay. | radioimmunoassay procedures employing highly specific antibodies for either serum t4 or t3 were utilized to determine t4 concentrations and t3 uptake values in normal cats. mean values for serum t4 and for t3 uptake were 30.9 ng/ml +/- 19 ng/ml and 59.67% +/- 12.2%, respectively. | 1979 | 525869 |
| supraglottic surgery in vestibular cancer. | this paper deals with the experience acquired in the e.n.t. clinic of the university of ferrara regarding horizontal supraglottic laryngectomy in vestibular cancer. the anatomical background of this functional surgery and the most important principles of the technique are specified. the results regard 121 cases (13 t1 cases, 93 t2 cases and 15 t4 cases) divided into three groups: 1. patients who had only surgery (68 cases); 2. patients who for various reasons also had complementary postoperative ... | 1979 | 526185 |
| [screening for cretinism using clinical check-list and measurement of t4 in filter paper blood sample (author's transl)]. | | 1979 | 527236 |
| comparison of t4, t3, rt3 and tsh concentrations in cord blood and serum of infants up to 3 months of age. | t4, t3, tsh and rt3 concentrations were measured by radioimmunoassay in cord and postnatal (8--94 days of age) serum samples from randomly selected normal newborn infants (group i). t4 and tsh levels also were determined in cord and postnatal sera from an additional group of apparently healthy infants 8--260 days of age, whose cord serum t4 levels were in the upper or lower 10% of the normal range of values (group ii). postnatal t4, t3 and tsh concentrations were stable over this age range; ther ... | 1979 | 527526 |
| effect of l-thyroxine treatment on the levels of various hepatic metabolites in rats. | the effects of l-thyroxine (t4) treatment upon hepatic metabolism of control and t4 treated rats was studied. livers were excised and freeze-clamped rapidly. the levels of adenine nucleotides and glycolytic and tca cycle metabolites were determined. the redox ratios of free pyridine nucleotides of cytoplasm and mitochondria were calculated from selected substrate concentrations. t4 treatment resulted in lower phosphorylation states and caused reduction in ratios of cytoplasmic nad and nadp and r ... | 1979 | 528840 |
| microdot t4 testing. | | 1979 | 530243 |
| endocrinology of pregnancy. i. denominations of concentrations of triiodothyronine, thyroxine, effective thyroxine, thyreotrophin and growth hormone in normal pregnancy, labour and in cord blood. | concentrations and activities of the following agents were estimated: triiodothyronine (t3), thyroxine (t4), effective thyroxine (etr), thyreotrophin (tsh), and growth hormone (hgh). blood samples were collected in pregnancy, labour and from the umbilical cord of the newborns. it was demonstrated that in normal pregnancy the concentrations of t3, etr, and tsh did not differ significantly from the values considered as normal in non-pregnant women. the concentration of t4 was distinctly higher in ... | 1979 | 532436 |
| haptoglobins act similar to antibodies. steps of discovery. analogous conclusions from pure preparations, umbilical cord sera and animal sera. | the haptoglobins in man and in mammals are agglutinin-like-substances for streptococci having the t4 antigen. the kind of the agglutinin-like behaviour depends on the genetic type of the haptoglobins. haptoglobins of the types hp 2-2, hp 2-2 like and hp 2-1 are hightitred complete agglutinins (titre in the range between 1:200 up to 1:3000 and higher) whereas haptoglobins of the type hp 1-1 are "blocking antibodies". - the steps of the discovery and evidence are presented in detail. different que ... | 1979 | 532442 |
| solubilization of thyroxine-5'-deiodinase activity from rat liver microsome fraction. | the greater part of t3 is converted from t4 in liver or kidney. the majority of this activity exists in microsomal fraction. in the present study, we investigated whether this activity can be solubilized from rat liver microsomal pellet with various concentrations of deoxycholate (doc). the extent of solubilization was compared with that of protein, rotenone insensitive nadh cytochrome c reductase or nadh cytochrome b5 reductase, which have been shown to associate with microsomal membrane rather ... | 1979 | 532525 |
| transient infantile hyperthyrotropinaemia. report of a case. | a case of transient hyperthyrotropinaemia was found by mass screening for neonatal hypothyroidism using the paired tsh assay method. the patient was a baby boy born at term after a normal pregnancy who grew without any abnormal signs or symptoms. for the first 7 months after birth, his serum tsh was abnormally high while his total serum t4, t3, and free t4, t3 were within normal limits, exept for slightly low free t4 level at 7 months. the raised serum tsh decreased spontaneously to within norma ... | 1979 | 533303 |
| evaluation of plasma hormone concentrations in relation to clinical staging in patients with prostatic cancer. british prostate study group. | plasma concentrations of testosterone, oestradiol-17 beta, luteinising hormone (lh), follicle stimulating hormone (fsh), prolactin and growth hormone (gh) were measured in patients with histologically proven prostatic cancer, before any form of therapy was given for this disease. patients were categorised according to uicc classification. no systemic change in the group means of any of these hormones was associated with the progression of the disease from the t0 to the t4 stage. when multivariat ... | 1979 | 533596 |
| cavernosography in the management of prostatic cancer. | cavernosograms were used in the investigation of 22 patients with prostatic cancer to determine the incidence of venous invasion. there were 21 patients with t3/t4 category tumours and one with a t2 tumour. all but one, a t3 tumour, had the radiological features of periprostatic venous malignant thrombosis. an attempt was made to correlate these findings with lymphography and tumour grade but no correlations could be made and the clinical relevance of these findings remains uncertain. | 1979 | 533598 |
| thyroid hormones and adipose tissue development. | the effect of thyroid hormones on the cellularity of the retroperitoneal adipose tissue (r.p.a.t.) was investigated in rats that were 3, 6 and 12 weeks old. two groups of rats were respectively made hypothyroid by the antithyroid compound propylthiouracil, or hyperthyroid by thyroxine. the number of adipocytes was less in the hypothyroid rats than in the controls; it was higher in the hyperthyroid rats without any concomitant increase in the weight of their r.p.a.t. moreover, there was no signif ... | 1979 | 533870 |
| reassembly of the bacteriophage t4 tail from the core-baseplate and the monomeric sheath protein p18: a co-operative association process. | | 1979 | 533896 |
| [studies on the measurement of serum thyroxine with "spac t4 ria kit" (author's transl)]. | | 1979 | 533936 |
| [treatment of ureteral obstructions due to prostatic carcinoma. prognostic value of response to medical treatment (author's transl)]. | a retrospective study concerning 146 patients with prostatic cancer showed that 30 of them (20 p.cent) presented ureteral obstacles at some time during the evolution of the disease. the majority of these cases were t3-t4 tumors. when a strickly medical approach allowed to reduce the obstruction, the 1 year survived rate was 71 p.cent. when surgery became necessary due to persistent renal insufficiency, in spite of medical treatment the 1 year survival rate was 15 p.cent. | 1979 | 534164 |
| hormonal factors in osteoporosis. | primary osteoporosis is a ubiquitous disease of unknown etiology. the condition undoubtedly has multiple causes and the metabolic pattern of bone loss may vary significantly from case to case. five hormones, pth, gonadal steroids, ct, t3 and t4, and glucocorticoids, and possibly a sixth, gh, have fundamental actions on bone metabolism and may therefore be causally involved in primary osteoporosis. a consideration of selected data on hormonal interactions culled from a much larger body of experim ... | 1979 | 535238 |
| effects of age on the metabolism of thyroid hormones by rat brain tissue in vitro. | using a newly-devised chromatographic method for the separation of the acetic and propionic analogues of triiodothyronine (t3) and thyroxine (t4), we studied the metabolism of radioactively labeled t3 and t4 in rat brain homogenates to determine whether the rates of metabolism and the types of products formed are influenced by the age of the animal. the separation of metabolites is achieved on silica gel h in a solvent system consisting of methylacetate-2.5% ammonia (w/v) (95:5 v/v). results cle ... | 1979 | 535533 |
| [thyroidal radioiodine uptake and t4 metabolism in nutritionally obese rats]. | | 1979 | 535576 |
| [t4 metabolism in age matched heavy and light rats with good and bad feed efficiency following high- or low-in-fat diet]. | rats, fed two diets (high or low in fat content), were at the and of the feeding-period separated in light and in heavy animal groups. the leaner rats from the diet group high in fat content show opposite to the heavier animals of this diet group significantly increased t4 distribution spaces, significantly shortened t4 half life time and lower feed efficiency. t4 serum values, absolute t4 degradation per day and body mass and free thyroxine index in these leaner rats also increased significantl ... | 1979 | 535577 |
| blood serum triiodothyronine (t3), thyroxine (t4) and thyroid stimulating hormone (tsh) concentrations in healthy children at the age of 1 and 2 years. | the physiological mean concentrations of t3, t4 an tsh in 150 healthy children aged from 1 month to 2 years of life decreased gradually with age. the statistically significant difference was observed only in t3 levels between the first and second year of life. the remaining parameters did not show statistically significant differences. | 1979 | 535584 |
| low muscle and liver glycogen contents in dogs treated with thyroid hormones. | muscle biopsies for glycogen determinations were taken from dogs before (controls) and after prolonged treatment with thyroid hormones (t4 or t3). the glycogen content in quadriceps femoris was measured before exercise, immediately after its cessation, and during 24h of post-exercise recovery. the effect of thyroxine treatment on the liver glycogen content both at rest and following physical effort was also studied. a marked decrease in the muscle glycogen content determined at rest was found bo ... | 1979 | 535882 |
| a study of age-dependent changes in thyroid function tests in adults. | total serum thyroxine (t4), triiodothyronine (t3), t3 resin uptake (t3u), thyrotrophin (tsh), and reverse t3 (rt3) were measured in 209 healthy adults 20--89 yr old. mean t4 values for men were stable throughout life, but in females under age 60, t4 values were significantly higher than in older women. values for t3u in males were significantly higher than in females throughout all decades, although females had a significant increase in t3u after age 60. tsh values increased significantly in fem ... | 1979 | 536771 |
| radioimmunoassay of free thyroxine with prebound anti-t4 microcapsules. | free thyroxine (ft4) may be one of the active throid hormones in contact with target end organs. it is unaffected by alterations in serum protein levels. in most cases, measurement of ft4 reflects an individual's true thyroid function or dysfunction. previous ft4 assay techniques have been difficult, tedious, indirect, and inaccurate. a rapid, simple, and accurate radioimmunoassay for ft4 has been developed using microencapsulated rabbit anti-t4 antiserum to which i-125 t4 tracer of high specifi ... | 1979 | 536842 |
| the effects of post-ganglionic axotomy on selective synaptic connexions in the superior cervical ganglion of the guinea-pig. | stimulation of preganglionic axons arising from different levels of the thoracic spinal cord causes different effects on end-organs supplied by the superior cervical ganglion (langley, 1892; nja & purves, 1977a; lichtman, purves & yip, 1979). for example, stimulation of the first thoracic ventral root (t1) causes pupillary dilatation and widening of the palpebral fissure; stimulation of t4, on the other hand, has little effect on the eye, even though axons arising from this level innervate about ... | 1979 | 536928 |
| three suppressor forms of bacteriophage t4 leucine transfer rna. | | 1979 | 537091 |
| the effect of rapeseed meal and methimazole on levels of plasma hormones in growing broiler cockerels. | the effects of feeding a heat treated rapeseed meal, which has goitrogenic properties, on the concentrations of plasma pituitary and thyroid gland hormones was investigated in broiler cockerels of between 3 and 10 weeks of age. for purposes of comparison, two other groups were included in the study; one was fed the goitrogen, methimazole, and the other a normal control diet. the hormones measured were thyroxine (t4), triiodothyronine (t3), growth hormone (gh), prolactin, and luteinizing hormone ... | 1979 | 537986 |
| the pathogenesis of propranolol-withdrawal syndrome in essential hypertension. | 1. in hypertension, the beta-adrenoreceptor-blocker-withdrawal syndrome comprises tachycardia, sweating, tremor and general malaise, symptoms resembling thyrotoxicosis. 2. the effect of abrupt cessation of propranolol on serum concentrations of thyroxine (t4) and triiodothyronine (t3) was therefore investigated in five patients with uncomplicated essential hypertension, treated with propranolol in doses from 160 to 480 mg/day. 3. four of the five patients developed one or more of the above-menti ... | 1979 | 540462 |
| changes in circulating l-thyroxine and l-triiodothyronine of the masu salmon, oncorhynchus masou accompaning the smoltification, measured by radioimmunoassay. | serum levels of l-thyroxine (t4) and l-triiodothyronine (t3) of the masu salmon, oncorhynchus masou, were measured by radioimmunoassay during the months from march to september. serum levels of t4 and t3 varied from 0.06 to 1.44 microgram and from 0.06 to 0.35 microgram per 100 ml serum respectively, although t4 content could not be detected in some specimens. t4 levels showed a seasonal fluctuation in which a higher value was observed in april when parr-smolt transformation was proceeding. t4 l ... | 1979 | 540573 |
| regulation of imm gene expression in bacteriophage t4-infected cells. | two polypeptides (imm-a and imm-b) which are not induced by an immunity mutant t4dimm2 but by a wild-type strain t4d were identified by sodium dodecyl sulphate (sds)-polyacrylamide gel electrophoresis. their mol. wt. were 77 000 and 45 000, respectively. these polypeptides exhibited a similar kinetic pattern of synthesis. within a few minutes p.i. the primary phage established the system that inhibited imm gene expression of superinfecting phage. this was shown by measuring both the phenotypic e ... | 1979 | 541664 |
| thyroid-hormone concentrations after radioiodine therapy for hyperthyroidism. | fourteen hyperthyroid patients (11 men, three women), ages 28-66, were followed with serial measurements of serum thyroid hormone levels for 1 mo after therapy with i-131. twelve patients had diffuse toxic goiters (25--70 g in size); two patients had multinodular glands (40--100 g). the patients were taking no antithyroid medications; ten patients were treated with propranolol. all patients received the equivalent of 5000 rad, except the two with multinodular glands, who received larger doses. t ... | 1979 | 541694 |
| [correlation between the plasma levels of t3, t4 and tsh in a normal population]. | | 1979 | 542676 |
| [effects of t3, t4 and methyltiouracile short-term treatments on plasma and liver lipid levels in rats (author's transl)]. | the effects of short-term administration of thyroid hormones (t3 and t4) and methyltiouracile (mtu) on liver and plasma lipid levels in female rats have been comparatively studied t3 increases the levels of all the studied liver lipids and decreases the plasma lipids. t4 produces smaller and even, in some cases (liver triglycerides and cholesterol esters), opposite effects. the administration of mtu produces, in general, opposite effects to t3 and t4. | 1979 | 542704 |
| thyroid function in breast cancer patients before and up to two years after mastectomy. | in 41 women newly diagnosed as having breast cancer the thyroid function was assessed by determination of the serum tsh, tririodothyronine (t3), reverse triiodothyronine (rt3), thyroxine (t4), t3-resin uptake and free t4-index. blood samples were drawn before the primary treatment and at follow-up after 7-28 months. there was no significant change in any of these variables during the period of observation. nor was there any difference between the values of the patients who developed recurrent di ... | 1979 | 543051 |
| [iodoamino acid distribution and weight of the thyroid gland, t4 serum level and t4 metabolism in relation to diet, body fat content and age of rats]. | rats were rendered obese by feeding them a fatty diet (hfd, fat: 50% of weight). at the end of the experimental period the animals were divided, also the control rats, which were fed a low-fat diet (lfd, fat: 3% of weight), in light and heavy weight groups. the heavy and obese hfd groups showed, unlike the light lfd-animals, equal absolute but significantly lower relative thyroidal weights. the absolute thyroidal weights of light and heavy animal groups, which received in each case the same diet ... | 1979 | 543366 |
| destruction of bacterial viruses in serum by heat and radiation under conditions that sustain the ability of serum to support growth of cells in suspended culture. | methods for inactivating bacterial viruses in serum were developed through the use of heat and ionizing radiation, and the effects of these treatments on the growth rates of cultured cells were tested. viruses chosen for this study were the radiation-resistant bacteriphage f2 and heat-resistant phage t4. the viabilities of these phages were reduced more than 2 and 4 orders of magnitude, respectively, by a treatment at 60 degrees c for 30 min followed by 420 krads of ionizing radiation. simultane ... | 1979 | 544633 |
| [variations in thyroid hormone levels concomitant with age in a normal population. ii: levels of t4 in plasma]. | | 1979 | 545468 |
| [relative variation of t3, t4 and tsh plasma levels in patients with primary hypothyroidism]. | | 1979 | 545481 |