Publications

the screening of antimicrobial bacteria with diverse novel nonribosomal peptide synthetase (nrps) genes from south china sea sponges.	nonribosomal peptide synthetase (nrps) adenylation (a) domain genes were investigated by polymerase chain reaction for 109 bacteria isolated from four south china sea sponges, stelletta tenuis, halichondria rugosa, dysidea avara, and craniella australiensis. meanwhile, the antimicrobial bioassay of bacteria with nrps genes were carried out to confirm the screening of nrps genes. fifteen bacteria were found to contain nrps genes and grouped into two phyla firmicutes (13 of 15) and proteobacteria ...	2012	18853226
investigation of bacteria with polyketide synthase genes and antimicrobial activity isolated from south china sea sponges.	to obtain bacteria with pks (polyketide synthase) genes and antimicrobial activity from sponges.	2009	19302490
a comparative study on the phylogenetic diversity of culturable actinobacteria isolated from five marine sponge species.	a cultivation-based approach was employed to compare the culturable actinobacterial diversity associated with five marine sponge species (craniella australiensis, halichondria rugosa, reniochalina sp., sponge sp., and stelletta tenuis). the phylogenetic affiliation of the actinobacterial isolates was assessed by 16s rdna-rflp analysis. a total of 181 actinobacterial strains were isolated using five different culture media (denoted as m1-m5). the type of medium exhibited significant effects on th ...	2008	17717723
a new cytotoxic cholesterol sulfate from marine sponge halichondria rugosa.	a new steroid, 24xi,25-dimethyl-3alpha-hydroxyl-cholest-5-ene-2beta-ol sodium sulfate (1), together with a known steroid, 24xi,25-dimethyl-cholest-5-ene-2beta,3alpha-diol disodium sulfate (2), was isolated from the ethanol extract of marine sponge halichondria rugosa. their structures were elucidated on the base of spectroscopic analysis. both compounds showed cytotoxicity to four human cancer cell lines (bel-7402, ht-29, spc-a1 and u-251) with ic(50) values between 6.5 and 23.1 microm.	2007	17691043
cultivable bacterial community from south china sea sponge as revealed by dgge fingerprinting and 16s rdna phylogenetic analysis.	the cultivable bacterial communities associated with four south china sea sponges-stelletta tenuis, halichondria rugosa, dysidea avara, and craniella australiensis in mixed cultures-were investigated by microbial community dna-based dgge fingerprinting and 16s rdna phylogenetic analysis. diverse bacteria such as alpha-, gamma-, delta-proteobacteria, bacteroidetes, and firmicutes were cultured, some of which were previously uncultivable bacteria, potential novel strains with less than 95% similar ...	2007	17896134
halichondria sulfonic acid, a new hiv-1 inhibitory guanidino-sulfonic acid, and halistanol sulfate isolated from the marine sponge halichondria rugosa ridley & dendy.	a new sulfur-containing guanidino derivative, halichondria sulfonic acid (1) showing anti-hiv-1 activity, and halistanol trisulfate (2) with anti-tumor activity have been isolated from the marine sponge halichondria rugosa ridley & dendy collected in the chinese southern sea. the structure of 1 was elucidated by analysis of spectroscopic and crystal data.	2006	17127667