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preliminary screening of a classical ayurvedic formulation for anticonvulsant activity.epilepsy is a serious and complex central nervous system disorder associated with recurrent episodes of convulsive seizures due to the imbalance between excitatory (glutamatergic) and inhibitory (gabaergic) neurotransmitters level in the brain. the available treatments are neither competent to control the seizures nor prevent progress of disease. since ages, herbal medicines have remained important sources of medicines in many parts of world which is evidenced through their uses in traditional s ...201728182033
insulin sensitizing effect of 3 indian medicinal plants: an in vitro study.measurement of glucose uptake into peripheral tissue is an important mechanism to assess insulin sensitivity. the present in vitro study was conducted to evaluate the insulin sensitizing activity of phyllanthus emblica (pe), tinospora cordifolia (tc) and curcuma longa (cl) by assessing glucose uptake activity in a 3t3l1 adipocyte model.201723543787
berberine and its role in chronic disease.berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids. it is found in such plants as berberis [e.g. berberis aquifolium (oregon grape), berberis vulgaris (barberry), berberis aristata (tree turmeric)], hydrastis canadensis (goldenseal), xanthorhiza simplicissima (yellowroot), phellodendron amurense ([2]) (amur corktree), coptis chinensis (chinese goldthread), tinospora cordifolia, argemone mexicana (prickly poppy) and eschscholzia californica (california ...201627671811
inhibition of imiquimod-induced psoriasis-like dermatitis in mice by herbal extracts from some indian medicinal plants.psoriasis is a chronic autoimmune human skin disorder that is characterized by excessive proliferation of keratinocytes, scaly plaques, severe inflammation and erythema. the pathophysiology of psoriasis involves interplay between epidermal keratinocytes, t lymphocytes, leukocytes and vascular endothelium. increased leukocyte recruitment and elevated levels of cytokines, growth factors and genetic factors like interleukin (il)-1β, il-6, il-17, il-22, il-23, tumour necrosis factor (tnf)-α, interfe ...201626016607
application of the kombucha 'tea fungus' for the enhancement of antioxidant and starch hydrolase inhibitory properties of ten herbal teas.ten herbal teas (acacia arabica, aegle marmelos flower, a. marmelos root bark, aerva lanata, asteracantha longifolia, cassia auriculata, hemidesmus indicus, hordeum vulgare, phyllanthus emblica, tinospora cordifolia) were fermented with the kombucha 'tea fungus'. the ph values of the fermented beverages ranged from 4.0 to 6.0 by day 7, while the titratable acidity ranged from 2.5 to 5.0g/ml (p<0.05). gallic acid had statistically significantly increased (p<0.05) in almost all the samples by day ...201626471559
attenuation of quorum sensing-regulated behaviour by tinospora cordifolia extract & identification of its active constituents.the pathogenicity of the nosocomial pathogens, pseudomonas aeruginosa and acinetobacter baumannii is regulated by their quorum sensing (qs) systems. the objective of the present study was to examine the effect of the cold ethyl acetate extract of tinospora cordifolia stem on virulence and biofilm development in the wild type and clinical strains of p. aeruginosa and a. baumannii. the study was further aimed to identify the probable active constituents in the plant extract.201627834332
antioxidant and in vivo genoprotective effects of phenolic compounds identified from an endophytic cladosporium velox and their relationship with its host plant tinospora cordifolia.tinospora cordifolia (willd. hook. f. & thomson; family: menispermaceae), has a long history of use in various traditional medicinal systems including "ayurveda". it is reported to possess anticancer, antidiabetic, antimicrobial, antispasmodic, and antiinflammatory activities. t. cordifolia has also been well documented for production of various bioactive metabolites and their antioxidant activity, but the microorganisms associated with it have been least explored for the same properties.201627721051
insecticidal potential of an endophytic cladosporium velox against spodoptera litura mediated through inhibition of alpha glycosidases.alpha glucosidase inhibitory activity was exhibited by partially purified fractions obtained from an endophytic cladosporium velox, isolated from tinospora cordifolia. taking into account the increasing importance of digestive enzyme inhibitors as insecticidal agents, the entomopathogenic potential of the fractions obtained was evaluated against spodoptera litura (fab.), a polyphagous pest. considerable mortality was obtained when the larvae were fed on diet supplemented with the partially purif ...201627265826
g1-4a, a polysaccharide from tinospora cordifolia inhibits the survival of mycobacterium tuberculosis by modulating host immune responses in tlr4 dependent manner.rapid emergence of drug resistance in mycobacterium tuberculosis (mtb) is a major health concern and demands the development of novel adjunct immunotherapeutic agents capable of modulating the host immune responses in order to control the pathogen. in the present study, we sought to investigate the immunomodulatory effects of g1-4a, a polysaccharide derived from the indian medicinal plant tinospora cordifolia, in in-vitro and aerosol mouse models of mtb infection. g1-4a treatment of mtb infected ...201627148868
the analgesic, anti-inflammatory and anti-pyretic activities of tinospora cordifolia.tinospora cordifolia (t. cordifolia) is a valuable resource due to its traditional uses in the treatment of pain, fever and inflammation, but no sufficient scientific literature is available online to confirm its traditional uses in these ailments.201626771966
evaluation of antiplasmodial activity of medicinal plants from north indian buchpora and south indian eastern ghats.development of resistance against the frontline anti-malarial drugs has created an alarming situation, which requires intensive drug discovery to develop new, more effective, affordable and accessible anti-malarial agents.201525879738
ethnomedicinal plants of kathua district, j&k, india.natural products, especially those derived from plants, continue to provide new and important leads in the drug discovery process. the first step in drug discovery is to document material traditionally used to treat an ailment. documentation of such knowledge will lead to its conservation and facilitate future research on medicinal plant safety and efficacy to validate traditional use. the present study was undertaken with an aim to document the ethnomedicinal plants of kathua district.201526023030
radioprotective and cytoprotective activity of tinospora cordifolia stem enriched extract containing cordifolioside-a.the present study was undertaken to evaluate the radioprotective and cytoprotective potential of cordifolioside-a, a primary active constituent of n-butanol fraction of tinospora cordifolia (nbtc) against 4 gy-γ radiation in mice and cyclophosphamide induced genotoxicity.201523833365
antifertility activity of medicinal plants.the aim of this review was to provide a comprehensive summary of medicinal plants used as antifertility agents in females throughout the world by various tribes and ethnic groups. we undertook an extensive bibliographic review by analyzing classical text books and peer reviewed papers, and further consulting well accepted worldwide scientific databases. we performed central, embase, and pubmed searches using terms such as "antifertility", "anti-implantation", "antiovulation", and "antispermatoge ...201525921562
chemical prospection of important ayurvedic plant tinospora cordifolia by uplc-dad-esi-qtof-ms/ms and nmr.a rapid, sensitive, and accurate ultra-performance liquid chromatography coupled with mass spectrometric method (uplc-ms) was developed and validated for simultaneous determination of four bioactive compounds, syringin (3), cordifolioside a (4), magnoflorine (6) and tinocordiside (10) in the stem of tinospora cordifolia. the analysis was performed using an acquity c18 column and gradient elution of 0.05% formic acid in water and acetonitrile at a detection wavelength of 267 nm in 5 min. a high c ...201525920217
effects of withania somnifera and tinospora cordifolia extracts on the side population phenotype of human epithelial cancer cells: toward targeting multidrug resistance in cancer.recent reports suggest the existence of a subpopulation of stem-like cancer cells, termed as cancer stem cells (cscs), which bear functional and phenotypic resemblance with the adult, tissue-resident stem cells. side population (sp) assay based on differential efflux of hoechst 33342 has been effectively used for the isolation of cscs. the drug resistance properties of sp cells are typically due to the increased expression of abc transporters leading to drug efflux. conventionally used chemother ...201525549922
an alpha-glucosidase inhibitor from an endophytic cladosporium sp. with potential as a biocontrol agent.this study highlights the importance of alpha-glucosidase inhibitors as mechanisms for endophyte-mediated resistance to insect pests. one of the major benefits which endophytes confer on plants is providing resistance against insect pests. this built-in defense mechanism of the plant can be used for exploring ecofriendly strategies for pest control. in the present study, 34 endophytic fungi were isolated from tinospora cordifolia and screened for their ability to produce alpha-glucosidase inhibi ...201525432333
analysis of glycation induced protein cross-linking inhibitory effects of some antidiabetic plants and spices.protein cross-linking which occurs towards the latter part of protein glycation is implicated in the development of chronic diabetic complications. glycation induced protein cross-linking inhibitory effects of nine antidiabetic plants and three spices were evaluated in this study using a novel, simple, electrophoresis based method.201526055093
short-term effect of g-400, polyherbal formulation in the management of hyperglycemia and hyperlipidemia conditions in patients with type 2 diabetes mellitus.salacia oblonga, tinospora cordifolia, emblica offinalis gaertn, curcuma longa and gymnema sylvestre are ayurvedic medicinal plants reported to lower plasma glucose levels in animal models. to our knowledge, however, no clinical validations of those extracts for efficacy have been. the aim of this study was to evaluate the effect of polyherbal combination in patients with type 2 diabetes mellitus.201424976431
comparative immunomodulation potential of tinospora cordifolia (willd.) miers ex hook. f., tinospora sinensis (lour.) merrill and tinospora cordifolia growing on azadirachta indica a. juss.guduchi has been widely used in the traditional medicine as an immunomodulator. description of guduchi in ayurvedic literature resemble with t. sinensis rather than with commonly available t. cordifolia and hence this may be used as substitutes for t. sinensis. t. cordifolia growing on azadirachta indica commonly called neem-guduchi has more immunomodulatory potential. thus, immunomodulatory activity of three tinospora spp. was assessed by checking humoral and cell mediated immune responses to t ...201425141544
useful ethnophytomedicinal recipes of angiosperms used against diabetes in south east asian countries (india, pakistan & sri lanka).this paper is based on data recorded from various literatures pertaining to ethnophytomedicinal recipes used against diabetes in south east asia (india, pakistan and srilanka). traditional plant treatments have been used throughout the world for the therapy of diabetes mellitus. in total 419 useful phytorecipes of 270 plant species belonging to 74 angiospermic families were collected. from the review it was revealed that plants showing hypoglycemic potential mainly belong to the families, cucurb ...201425176368
involvement of liver in diabetes mellitus: herbal remedies.liver disease is considered as one of the major complications in oxidative stress disorders like diabetes mellitus (dm). dm presents with deterioration in carbohydrate metabolism which is characterized with chronic hyperglycemia. the organ which involves in glucose or carbohydrate metabolism and is most likely to be affected is the liver. deterioration in liver architecture and metabolism in dm, are considered as common findings. in the present review both biochemical and histological changes oc ...201425203338
ethnoveterinary study of medicinal plants in a tribal society of sulaiman range.the aims of the present study were (i) to document ethnoveterinary plants and their formulation techniques in an unexplored region of pakistan and (ii) to select candidate medicinal plants with high consensus factor and fidelity value for further in vitro investigation. a total of 60 informants were interviewed using semistructured questionnaire. a total of 41 plants belonging to 30 families were used to treat livestock ailments in study area. mostly leaves (47%) were used in recipes formulation ...201425405212
tinospora cordifolia as a protective and immunomodulatory agent in combination with cisplatin against murine visceral leishmaniasis.effect of pure herb, tinospora cordifolia was studied for its hepatoprotective, nephroprotective and immunomodulatory activity against high dose cisplatin treatment in leishmania donovani infected balb/c mice. administration of cisplatin (5mg/kg b.wt. daily for 5 days, i.p.) reduced the parasite load in l. donovani infected balb/c mice but produced damage in liver and kidney as manifested biochemically by an increase in serum glutamate oxaloacetate transaminase (sgot), serum glutamate pyruvate t ...201424370645
bactericidal activity of selected medicinal plants against multidrug resistant bacterial strains from clinical isolates.to investigate the antibacterial effect of curcuma longa (c. longa), zingiber officinale (z. officinale) and tinospora cordifolia (t. cordifolia) against staphylococcus aureus, pseudomonas aeruginosa, klebsiella pneumoniae, escherichia coli, bacillus subtilis and proteus mirabilis of clinical origin.201425312164
ethanolic extracts of tinospora cordifolia and alstonia scholaris show antimicrobial activity towards clinical isolates of methicillin-resistant and carbapenemase-producing bacteria.the aim of this study was to determine the in vitro antimicrobial activity of crude extracts of three plants from ayurveda tradition (tinospora cordifolia, alstonia scholaris, crataeva nurvala) against reference microbial strains and clinical isolates of methicillin-resistant staphylococcus aureus (mrsa) and carbapenemase-producing klebsiella pneumoniae. ic50 values were obtained by micro-dilution methods meeting the requirements of the nccls standard. the cytotoxicity of the extracts was also i ...201424749692
scientific validation of the medicinal efficacy of tinospora cordifolia.present communication reports the scientific evaluation of tinospora cordifolia for its medicinal efficacy which includes phytochemical screening, antimicrobial, antioxidant, and anticancer activities of the plant. secondary metabolites including anthraquinones, terpenoids, and saponins were present in many extracts in addition to phenolics. total phenol contents in various extracts were found in the range of 8.75-52.50 catechol equivalent per gram (ce/g). in disc diffusion assays, polar extract ...201324453828
effects of medhya rasayana and yogic practices in improvement of short-term memory among school-going children.excellent memory, extraordinary intelligence, great academic achievement, and successful career are the dreams of every individual in this era of competition and professionalism. a good memory power acts as a catalyst in all walks of life, be it academic success or maintenance of personal relationships. it is observed that an average man uses only 10% of his natural memory. remaining 90% is left unused in a haphazard manner. as per the american psychologist carl emil seashore, if one is alert an ...201324695779
enhanced resistance to spodoptera litura in endophyte infected cauliflower plants.endophytic fungi, which live within host plant tissues without causing any visible symptom of disease, are important mediators of plant-herbivore interactions. these endophytes enhance resistance of host plant against insect herbivores mainly by productions of various alkaloid based defensive compounds in the plant tissue or through alterations of plant nutritional quality. two endophytic fungi, i.e., nigrospora sp. and cladosporium sp., were isolated from tinospora cordifolia (thunb.) miers, a ...201323575013
do plants mediate their anti-diabetic effects through anti-oxidant and anti-apoptotic actions? an in vitro assay of 3 indian medicinal plants.both experimental and clinical studies suggest that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. this oxidative stress leads to β-cell destruction by apoptosis. hence exploring agents modulating oxidative stress is an effective strategy in the treatment of both type i and type ii diabetes. plants are a major source of anti-oxidants and exert protective effects against oxidative stress in biological systems. phyllanthus emblica, curcuma longa and tin ...201324093976
anti-diabetic formulations of nāga bhasma (lead calx): a brief review.ayurvedic formulations usually contain ingredients of herbal, mineral, metal or animal in origin. nāga bhasma (lead calx) is a potent metallic formulation mainly indicated in the treatment of prameha (~diabetes). until date, no published information is available in compiled form on the formulations containing nāga bhasma as an ingredient, their dose and indications. therefore, in the present study, an attempt has been made to compile various formulations of nāga bhasma indicated in treating pram ...201325161332
clinical evaluation of rasayana compound as an adjuvant in the management of tuberculosis with anti-koch's treatment.tuberculosis (tb) continues to intimidate the human race since time immemorial not only due to its effects as a medical malady, but also by its impact as a social and economic tragedy. at the dawn of the new millennium, we are still mute witnesses to the silent yet efficient march of this sagacious disease, its myriad manifestations and above all its unequalled, vicious power. through the millennia, tb never ever disappeared from the developing world. in 1991, the world health assembly (wha) res ...201223049182
hydroalcoholic extracts of indian medicinal plants can help in amelioration from oxidative stress through antioxidant properties.the in vitro study of the antioxidant properties of the hydroalcoholic extracts of various indian medicinal plants can logically help to develop a better and safer way of amelioration from oxidative stress. as aimed, the present study has been done to estimate and thereby conclude regarding the antioxidant activities of a few indian medicinal plants, viz., terminalia chebula, terminalia belerica, emblica officinalis, caesalpinia crista, cajanus cajan, and tinospora cordifolia. the extracts of th ...201222624183
influence of feeding tinospora cordifolia peripartum on lactation parameters in crossbred cows.for studying the effect of dietary supplementation of guduchi (tinospora cordifolia) peripartum on lactation an investigation was conducted on 15 pregnant karan fries crossbred cows which were divided into two groups: treatment group of eight cows which were supplemented with guduchi at 60 g/day for 45 days prepartum and 120 g/day for 45 days postpartum; control group of seven pregnant cows which were not supplemented with guduchi. jugular blood samples were collected from all cows during the pe ...201221895784
the treatment of jaundice with medicinal plants in indigenous communities of the sub-himalayan region of uttarakhand, india.inspite of tremendous advances made in allopathic medical practices, herbs still play an important role in the management of various liver diseases. a large number of plants and formulations have been claimed to have hepatoprotective activity. jaundice is a symptom, indicative of the malfunctioning of the liver. this paper provides ethnomedicinal information on the plants used to treat jaundice by three important indigenous communities, i.e., nomadic gujjars, tharu and bhoxa of sub-himalayan reg ...201222759701
a pharmacological appraisal of medicinal plants with antidiabetic potential.diabetes mellitus is a complicated metabolic disorder that has gravely troubled the human health and quality of life. conventional agents are being used to control diabetes along with lifestyle management. however, they are not entirely effective and no one has ever been reported to have fully recovered from diabetes. numerous medicinal plants have been used for the management of diabetes mellitus in various traditional systems of medicine worldwide as they are a great source of biological const ...201222368396
ethnoveterinary remedies of diseases among milk yielding animals in kathua, jammu and kashmir, india.the triangle of relationship between human beings, animals and plants has existed for ages, and has given rise to intense-relationships and consequently rich traditions of ethnoveterinary knowledge throughout the world. the predominantly rural population and the strong agricultural base have provided unique situation for rich ethnoveterinary practices in the study area.201222366093
tinospora cordifolia: one plant, many roles.natural products with medicinal value are gradually gaining importance in clinical research due to their well-known property of no side effects as compared to drugs. tinospora cordifolia commonly named as "guduchi" is known for its immense application in the treatment of various diseases in the traditional ayurvedic literature. recently the discovery of active components from the plant and their biological function in disease control has led to active interest in the plant across the globe. our ...201223661861
season and tissue type affect fungal endophyte communities of the indian medicinal plant tinospora cordifolia more strongly than geographic location.a total of 1,151 endophytic fungal isolates representing 29 taxa were isolated from symptom-less, surface-sterilized segments of stem, leaf, petiole, and root of tinospora cordifolia which had been collected at three locations differing in air pollution in india (ramnagar, banaras hindu university, maruadih) during three seasons (summer, monsoon, winter). endophytes were most abundant in leaf tissues (29.38% of all isolates), followed by stem (18.16%), petiole (10.11%), and root segments (6.27%) ...201222430503
Ameliorative effects of tinospora cordifolia root extract on histopathological and biochemical changes induced by aflatoxin-b(1) in mice kidney.The present study was planned to investigate the ability of the Tinospora cordifolia to scavenge free radicals generated during aflatoxicosis. A total no. of 48 male Swiss albino mice (30 ± 5 g) were exposed to Aflatoxin B(1)(AFB(1)) (2 µg/30 g b.wt, orally) either individually or in combination with T. cordifolia (50, 100, 200 mg/kg, orally) once daily for 25 days. AFB(1) exposure led to significant rise in thiobarbituric acid reactive substances (TBARS) and fall in superoxide dismutase (SOD), ...201121976812
Antibacterial activity of selected medicinal plants against multiple antibiotic resistant uropathogens: a study from Kolli Hills, Tamil Nadu, India.The increasing incidence of antibiotic resistance among bacterial pathogens necessitates medicinal plants as an alternate therapy in restricting the resistant infectious organisms. In this primitive study, the antibiotic resistance of organisms isolated from urinary tract infected patients was evaluated using the National Committee for Clinical Laboratory Standards (NCCLS) method and Multiple Antibiotic Resistance (MAR) index values, and the MAR values was also calculated for plant extracts. The ...201121986363
medico - botanical study of yercaud hills in the eastern ghats of tamil nadu, india.the study reports medicinal plant survey was conceded in yercaud hills ranges of eastern ghats, tamil nadu, india. the study primarily based on field surveys conducted throughout the hills, where dwellers provided information on plant species used as medicine, plant parts used to prepare the remedies and ailments to which the remedies were prescribed. the study resulted about 48- plant species belonging to 45- genera and 29- families of medicinal plants related to folk medicine used by the local ...201122557438
evaluation of anti-depressant and anxiolytic activity of rasayana ghana tablet (a compound ayurvedic formulation) in albino mice.in recent years, many ayurvedic formulations are being researched to provide an effective antidepressant and anxiolytic drug in the field of psycho-pharmacology. the present study was planned to evaluate the anti-depressant and anxiolytic activity of rasayana ghana tablet comprising three herbs guduchi (tinospora cordifolia miers), aamalaki (emblica officinalis garten) (rgt) and gokshura (tribulus terrestris linn). swiss albino mice were divided into four groups of six animals each, comprising o ...201122529654
synthesis of pediculocidal and larvicidal silver nanoparticles by leaf extract from heartleaf moonseed plant, tinospora cordifolia miers.insecticide resistance and inadequate attention to the application instructions of topical pediculicides are common reasons for treatment failure. essential oils or plant extracts are good and safe alternatives due to their low toxicity to mammals and easy biodegradability. the present study was carried out to establish the pediculocidal and larvicidal activity of synthesized silver nanoparticles (agnps) using leaf aqueous extract of tinospora cordifolia miers (menispermaceae) against the head l ...201121212979
potent α-amylase inhibitory activity of indian ayurvedic medicinal plants.indian medicinal plants used in the ayurvedic traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post-prandial hyperglycemia via control of starch breakdown. in this study, seventeen indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory po ...201121251279
radiation-induced testicular injury and its amelioration by tinospora cordifolia (an indian medicinal plant) extract.the primary objective of this investigation is to determine the deleterious effects of sub lethal gamma radiation on testes and their possible inhibition by tinospora cordifolia extract (tce). for this purpose, one group of male swiss albino mice was exposed to 7.5?gy gamma radiation to serve as the irradiated control, while the other group received tce (75?mg/kg?b.?wt./day) orally for 5 consecutive days half an hr before irradiation to serve as experimental. exposure of animals to 7.5?gy gamma ...201121350610
tinospora cordifolia attenuates oxidative stress and distorted carbohydrate metabolism in experimentally induced type 2 diabetes in rats.diabetes is a chronic metabolic disorder affecting a vast number of people worldwide. oxidative stress is the causative agent amplifying diabetic complications in various organs by generating noxious amount of free radicals. a huge interest always exists in exploring nutraceuticals from plant materials to replace synthetic drugs in order to overcome their adverse effects and also for economic reasons. the anti-diabetic efficiency of a medicinal plant, tinospora cordifolia (tc) was studied in exp ...201121538233
profile of aldose reductase inhibition, anti-cataract and free radical scavenging activity of selected medicinal plants: an attempt to standardize the botanicals for amelioration of diabetes complications.phytotherapy has played an important role in the management of diabetes and related complications. in the present study different fractions of catharanthus roseus l. (apocynaceae), ocimum sanctum l. (labiatae), tinospora cordifolia willd. (menispermaceae), aegle marmelos l. (rutaceae), ficus golmerata l. (moraceae), psoralea corlifolia l. (fabaceae), tribulus terrestris l. (zygophyllaceae), and morinda cetrifolia l. (rubiaceae) were evaluated as possible inhibitors of aldose reductase (ar: a key ...201121570444
hypoglycemic activity of alkaloidal fraction of tinospora cordifolia.the stem of tinospora cordifolia (tc) is widely used in the therapy of diabetes in traditional folk medicine of india. in the present study, isoquinoline alkaloid rich fraction (aftc) derived from stem of tc and three alkaloids viz., palmatine, jatrorrhizine and magnoflorine were evaluated for insulin-mimicking and insulin-releasing effect in vitro and in vivo. their effect on hepatic gluconeogenesis was examined in rat hepatocytes. insulin releasing effect was detected in vitro using rat pancre ...201121665451
evaluation of antidiabetic and related actions of some indian medicinal plants in diabetic rats.to evaluate antidiabetic activity of chloroform extracts of acacia arabica bark, benincasa hispida fruit, tinispora cordifolia stem, ocimum sanctum areal parts and jatropha curcus leaves.201121771409
[hepatoprotective effects of orally administered melatonin and tinospora cordifolia in experimental jaundice].posthepatic cholestasis is figured by the onset of an intense oxidative stress, followed by important cellular morphological and functional abnormalities. the aim of this experimental study is to assess the hepatoprotective effects of melatonin and extract of tinospora cordifolia in bile duct ligation induced jaundice in rats. we choosed to administrate both pharmacological products per os, in order to compare the results with those already published, in which melatonin was administrated injecta ...201121698863
immunostimulatory properties of the major protein from the stem of the ayurvedic medicinal herb, guduchi (tinospora cordifolia).guduchi (tinospora cordifolia), a widely used plant in folk and ayurvedic systems of medicine is well known for its immunomodulatory activity; however, the presence of an immunomodulatory protein (imp) in guduchi has not been investigated.201122119223
abrogation of maternal and fetal oxidative stress in the streptozotocin-induced diabetic rat by dietary supplements of tinospora cordifolia.objective: diabetes during pregnancy increases the incidences of congenital anomalies, morbidity, and mortality in the mother and her fetus/newborn. oxidative stress (os) has been implicated to be responsible because various antioxidants have been demonstrated to be beneficial in diabetic embryopathy. in this study, we examined the propensity of tinospora cordifolia (tc) to attenuate embryopathy and os in pregnant diabetic rats. methods: pregnant rats were rendered diabetic with streptozotocin ( ...201122189193
effect of aqueous extract of tinospora cordifolia on functions of peritoneal macrophages isolated from ccl4 intoxicated male albino mice.the current practice of ingesting phytochemicals for supporting the immune system or fighting infections is based on centuries-old tradition. macrophages are involved at all the stages of an immune response. the present study focuses on the immunostimulant properties of tinospora cordifolia extract that are exerted on circulating macrophages isolated from ccl(4) (0.5 ml/kg body weight) intoxicated male albino mice.201122035196
clinical evaluation of shilajatu rasayana in patients with hiv infection.aids is one of the serious global health concerns caused by human immuno deficiency(hiv) virus and is predominantly a sexually transmitted disease. currently there is no vaccine or cure for aids still anti retroviral therapy (art) is successful. it reduces both the mortality and the morbidity of hiv infection, but is expensive and inaccessible in many countries. however intense the therapy may be, hiv virus is rarely eliminated, and drug resistance is a major setback during long-term therapy. th ...201022131681
antipyretic activity of guduchi ghrita formulations in albino rats.the present pharmacological investigation was undertaken to study the anti-pyretic activity of guduchi ghrita formulations in albino rats against yeast induced pyrexia. seven groups of six animals were used for the experiment. the yeast induced pyrexia method was standardized first by injecting 12.5% yeast suspension (s.c) followed by recording the rectal temperature at regular intervals. then the evaluation of anti-pyretic activity of guduchi ghrita formulations was carried out by using this st ...201022131741
antioxidant effect of tinospora cordifolia extract in alloxan-induced diabetic rats.many plants are claimed to possess antidiabetic and antioxidant activity. in practice, it is being increasingly recognized to be an alternative approach to modern medicine. this study assess the antioxidant capacity of tinospora cordifolia stem methanol extract in daily oral administration of 500 mg/kg of body weight for 40 days in alloxan induced diabetic rats. the erythrocytes membrane lipid peroxide and catalase activity was increased where as the activities of superoxide dismutase, glutathio ...201021969757
beneficial effects of beta-ecdysone on the joint, epiphyseal cartilage tissue and trabecular bone in ovariectomized rats.ecdysteroids are steroids found in invertebrates and plants. in mammals they have protein anabolic effects. we have recently published antiosteoporotic effects of tinospora cordifolia (tc) extract and the search for the possible active ingredients yielded the presence of beta-ecdysone (ecd). therefore, we investigated the effects of pure ecd in ovariectomized rats on morphological changes in joint, epiphyseal cartilage and trabecular tissue. following ovariectomy rats were fed for 1 month with e ...201020171072
trace element studies on tinospora cordifolia (menispermaceae), ocimum sanctum (lamiaceae), moringa oleifera (moringaceae), and phyllanthus niruri (euphorbiaceae) using pixe.traditionally, tinospora cordifolia (willd.) hook. f. & thomson (menispermaceae), ocimum sanctum l. (lamiaceae), moringa oleifera lam. (moringaceae), and phyllanthus niruri l. (euphorbiaceae) are some of the commonly used medicinal plants in india for curing ailments ranging from common cold, skin diseases, and dental infections to major disorders like diabetes, hypertension, jaundice, rheumatism, etc. to understand and correlate their medicinal use, trace element studies on the aqueous extract ...201019588079
evaluation of mammary gland immunity and therapeutic potential of tinospora cordifolia against bovine subclinical mastitis.enhancement of the diseased mammary gland immunity and therapeutic potential of hydro-methanolic extract of tinospora cordifolia (t. cordifolia; stem) in bovine subclinical mastitis was investigated. somatic cell count (scc), total bacterial count (tbc), phagocytic activity, and leukocyte lysosomal enzymes like myeloperoxidase and acid phosphatase activity and interleukin-8 (il-8) level were evaluated after intramammary infusion of hydro-methanolic extract (stem) of t.cordifolia in diseased cows ...201019876755
beta-ecdysone has bone protective but no estrogenic effects in ovariectomized rats.estrogens exert beneficial effects in the bone. their chronic use however bares several risks. therefore intensive search for non-estrogenic, bone protective compounds is going on. we observed that an extract of tinospora cordifolia has antiosteoporotic effects and identified 20-oh-ecdysone (beta-ecdysone=ecd) as a possible candidate for this action. ovariectomized (ovx) rats were treated orally over 3 months with no ecd (control) or 18, 57 or 121 mg ecd/day/animal. estradiol-17beta benzoate (e2 ...201020554186
use of tinospora cordifolia in hiv infection. 201020606842
water soluble fraction of tinospora cordifolia leaves enhanced the non-specific immune mechanisms and disease resistance in oreochromis mossambicus.the present paper describes the effect of water-soluble fraction of the leaves of the indian medicinal plant, tinospora cordifolia (miers) on the non-specific immunity and disease resistance in oreochromis mossambicus (peters). fish were intraperitoneally injected with 0, 6, 60 or 600 mg kg(-1) body weight, of the water soluble fraction. the non-specific humoral (lysozyme, antiprotease and complement) and cellular (production of reactive oxygen and nitrogen species and myeloperoxidase) responses ...201020624469
a comparative pharmacological investigation of three samples of 'guduchi ghrita' for adaptogenic activity against forced swimming induced gastric ulceration and hematological changes in albino rats.this study was undertaken to investigate the impact of formulation factors and adjuvants on the expression of biological activity of tinospora cordifolia (willd.) miers. the adaptogenic effect of three samples of guduchi ghrita, prepared using plain ghee (clarified butter) obtained from three different sources was studied in albino rats and compared with expressed juice of stem of guduchi. the test preparations were evaluated against forced-swimming induced hypothermia, gastric ulceration and ch ...201020814518
tinospora cordifolia ameliorates urotoxic effect of cyclophosphamide by modulating gsh and cytokine levels.cyclophosphamide (cp) is a commonly used anti-cancer drug which causes toxicity by its reactive metabolites. in this study we investigated the effect of tinospora cordifolia on urotoxicity induced by acute dose of cp using swiss albino mice model. administration of an alcoholic extract of the plant t. cordifolia (family: menispermaceae) (200mg/kg i.p.) for 5 days reduced cp (1.5mmol/kg body wt. i.p.) induced urotoxicity as evident from the morphological analysis of bladder, decreased the relativ ...201020932729
beneficial effects of tinospora cordifolia on blood profiles in male mice exposed to lead.this study was carried out to evaluate in vivo protective role of aqueous extract of stem and leaves of tinospora cordifolia (tc) on the toxic effects of lead on the hematological values. the lead-treated (5 mg/kg body weight, intraperitonially, once daily) male albino mice concurrently received either t. cordifolia stem or leaves extracts (400 mg/kg body weight, orally, once daily) for the duration of 30 days. the animals exposed to lead showed significant decrease in rbc and hb level. signific ...201021042466
protective role of tinospora cordifolia against lead-induced hepatotoxicity.the importance of tinospora cordifolia stem and leaves extract was investigated for its possible hepatoprotective effect in swiss albino male mice against lead nitrate induced toxicity. oral administration of plant extracts prevented the occurrence of lead nitrate induced liver damage. the decreased level of tissue enzymes, i.e., superoxide dismutase (sod), catalase (cat) and increased level of aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosphatase (alp), and acid ...201021042467
effects of supplementation of tinospora cordifolia to crossbred cows peripartum.guduchi (tinospora cordifolia), a medicinal plant used in ayurveda, is well documented for its immunomodulatory properties. since the crossbred periparturient cow is highly susceptible to various diseases that effectively reduces its reproductive performance postpartum we explored the possibility of enhancing the reproductive performance of crossbred cows by guduchi supplementation peripartum. a total of 15 pregnant karan fries cows were selected and divided into two groups: treatment group of 8 ...201021163594
antipsychotic activity of aqueous ethanolic extract of tinospora cordifolia in amphetamine challenged mice model.tinospora cordifolia is reported to have cns active principle and is used for the treatment of various neurological disorders. hence, the effect of aqueous ethanolic extract of tinospora cordifolia was investigated for its putative antipsychotic activity using amphetamine challenged mice model. haloperidol (1 mg/kg i.p.) was administered acutely to mice as standard drug. control animals received vehicle (10% dmso). the in vivo receptor binding studies were carried out to correlate the antipsycho ...201022247829
immunological response to (1,4)-alpha-d-glucan in the lung and spleen of endotoxin-stimulated juvenile rats.we investigated the effects of (1,4)-alpha-d-glucan (alpha-dg), a novel immune stimulatory drug from tinospora cordifolia, on the concentration of pro- and anti-inflammatory cytokines (interleukin [il]-1beta, il-6, tumour necrosis factor-alpha [tnf-alpha], gamma-interferon [ifn-gamma] and il-10) in the lung and spleen of endotoxin-stimulated juvenile rats. experimental groups (n = 16/group) included controls with an intraperitoneal injection of saline, endotoxaemic rats with a non-lethal dose of ...200919627280
tinospora cordifolia, a safety evaluation.tinospora cordifolia is one of the indispensable medicinal plants used in veterinary folk medicine/ayurvedic system of medicine for the treatment of diverse diseases and recommended for improving the immune system by means of body resistance. in the current study, we evaluated the genotoxic risk of the aqueous extract of t. cordifolia (tc) in a battery of four different genotoxicity tests viz., ames, in vitro chromosome aberration (ca), rodent bone marrow micronucleus (mn), and comet assay. expe ...200919651204
antihyperglycemic, antihyperlipidemic and antioxidant effects of dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats.present investigation was undertaken to evaluate antihyperglycemic, antihyperlipidemic and antioxidant activities of dihar, a polyherbal formulation containing drugs from eight different herbs viz., syzygium cumini, momordica charantia, emblica officinalis, gymnema sylvestre, enicostemma littorale, azadirachta indica, tinospora cordifolia and curcuma longa in streptozotocin (stz, 45 mg/kg iv single dose) induced type 1 diabetic rats. stz produced a significant increase in serum glucose, choleste ...200919761040
beneficiary effect of tinospora cordifolia against high-fructose diet induced abnormalities in carbohydrate and lipid metabolism in wistar rats.high intake of dietary fructose has been shown to exert a number of adverse metabolic eff ects in humans and experimental animals. the present study was designed to investigate the eff ect of the aqueous extract of tinospora cordifolia stem (tcae) on the adverse eff ects of fructose loading toward carbohydrate and lipid metabolism in rats. adult male wistar rats of body weight around 200 g were divided into four groups, two of which were fed with starch diet and the other two with high fructose ...200919764107
screening of antibacterial potentials of some medicinal plants from melghat forest in india.cyperus rotundus, caesalpinia bonducella, tinospora cordifolia, gardenia gummifera, ailanthus excelsa, acacia arabica, embelia ribes and ventilago maderspatana from melghat forest were screened for their antibacterial potential against escherichia coli, staphylococcus aureus, klebsiella pneumoniae, proteus vulgaris, salmonella typhi, shigella flexneri, salmonella paratyphi, salmonella typhimurium, pseudomonas aeruginosa, enterobacter aerogenes by disc diffusion method. out of these medicinal pla ...200920448847
chemopreventive potential of epoxy clerodane diterpene from tinospora cordifolia against diethylnitrosamine-induced hepatocellular carcinoma.medicinal plants are a promising source for identification of lead molecules for cancer therapy. in our continuous search to discover bioactive compounds from natural products, we isolated (5r, 10r)-4r, 8r-dihydroxy-2s, 3r:15, 16-diepoxycleroda-13(16), 17, 12s:18,1s-dilactone (ecd), a diterpenoid from tinospora cordifolia and studied its chemopreventive potential in diethylnitrosamine (den) induced hepatocellular carcinoma (hcc) rats. fifty male wistar rats were divided into five groups. group i ...200918853103
hypoglycemic activity of the antioxidant saponarin, characterized as alpha-glucosidase inhibitor present in tinospora cordifolia.tinospora cordifolia, used in anti-diabetic herbal drug preparations, was reported [12] to contain an alpha-glucosidase inhibitor, characterized as saponarin (apigenin-6-c-glucosyl-7-o-glucoside). the leaf extract had appreciable antioxidant and hydroxyl radical scavenging activities and contained the flavonoid in the range of 32.1 +/- 1.5-45.5 +/- 3.5 mg/g of dry solid. saponarin showed mixed competitive inhibition on activities of alpha-glucosidase and sucrase of different origins. ic(50), ki ...200918951283
androgenic action of tinospora cordifolia ethanolic extract in prostate cancer cell line lncap.recently, tinospora cordifolia (tc) was shown to affect prostate growth in rats. it is not known whether this is a direct effect of tc or whether it is induced by altered hormone release. to investigate the actions of tc on the prostate, human lncap cells were exposed to an ethanolic extract of tc.200919097771
physiological effects of a novel immune stimulator drug, (1,4)-alpha-d-glucan, in rats.the (1,4)-alpha-d-glucan (alpha-d-glucan), derived from medicinal plant, tinospora cordifolia, activates human lymphocytes with downstream synthesis of the pro- and anti-inflammatory cytokines, in vitro. we investigated physiological and immunological effects of a low and a high dose of alpha-d-glucan (0.5 and 10 mg/kg), in vivo, testing the hypothesis that intravenous administration of alpha-d-glucan does not affect haemodynamic, respiratory, haematological, and immune responses in normal rats. ...200919389049
molecular events in the activation of b cells and macrophages by a non-microbial tlr4 agonist, g1-4a from tinospora cordifolia.g1-4a, a polysaccharide from an indian medicinal plant tinospora cordifolia, was recently shown to protect mice against septic shock by modulating the proinflammatory cytokines. g1-4a also activated b cells polyclonally. the present report describes in detail the molecular events associated with g1-4a-induced immunomodulation in vitro and in vivo. g1-4a treatment led to an increase in the cd69 expression in lymphocytes. g1-4a-induced proliferation of b cells was completely inhibited by pi3k inhi ...200919428553
preventive effect of tinospora cordifolia against high-fructose diet-induced insulin resistance and oxidative stress in male wistar rats.high intake of dietary fructose exerts a number of adverse metabolic effects. the aim of the present study was to investigate whether aqueous extract of tinospora cordifolia stem (tcae) alleviates high-fructose diet-induced insulin resistance and oxidative stress in rats. high-fructose diet (66% of fructose) and tcae (400 mg/kg/day) were given simultaneously for a period of 60 days. fructose fed rats showed hyperglycemia, hyperinsulinemia, hypertriglyceridemia, impaired glucose tolerance and imp ...200919520137
alpha glucosidase inhibition by stem extract of tinospora cordifolia.inhibitors of alpha glucosidase have potential use in the treatment of diabetes mellitus. the stem extract of tinospora cordifolia was evaluated for inhibition of the enzyme. the extract was also found to inhibit the salivary and pancreatic amylase and therefore can effectively reduce an increase in postprandial glucose level. the crude ethyl acetate, dichloromethane (dcm), chloroform and hexane extracts of tinospora cordifolia were studied. 15 mg of the dcm extract was most effective in that sh ...200919555164
evaluation of the antiosteoporotic potential of tinospora cordifolia in female rats.the available courses of therapy to osteoporosis in menopausal women are limited by several side effects generated. a need therefore arises to explore herbal alternatives that are effective and safe.200818482809
octacosanol isolated from tinospora cordifolia downregulates vegf gene expression by inhibiting nuclear translocation of nf-<kappa>b and its dna binding activity.octacosanol is a long-chain aliphatic alcohol, which is the main component of policosanol used as a normolipidemic agent. it is known that angiogenesis is involved in tumor growth and metastasis. the present study identified octacosanol isolated from the plant tinospora cordifolia as a new antiangiogenic compound with inhibitory effects on in vivo angiogenesis assays. our results showed that octacosanol (i) inhibits proliferation of endothelial cells and ehrlich ascites tumor cells, (ii) inhibit ...200818513715
chemopreventive potential of an indian medicinal plant (tinospora cordifolia) on skin carcinogenesis in mice.tinospora cordifolia (guduchi), an indian medicinal plant, was used to explore antitumor promoting activity in a two-stage skin carcinogenesis model. for this purpose, mice were treated by single application of dmba (100 microg/100 microl of acetone) and two weeks later promoted by croton oil (1% in acetone three times a week) until the end of the experiment (i.e., 16 weeks). oral administration of the above extract at the preinitiational stage (i.e., seven days before and seven days after dmba ...200818652570
preliminary investigation of the radiosensitizing activity of guduchi (tinospora cordifolia) in tumor-bearing mice.the radiosensitizing activity of dichloromethane extract of guduchi [tinospora cordifolia (willd.) miers ex hook. f. & thoms. family: menispermaceae (tce)] in the mice transplanted with ehrlich ascites carcinoma (eac) was investigated. the eac mice received 0, 25, 30, 40, 50 or 100 mg/kg b.wt. tce 1 h before exposure to 6 gy hemi-body gamma-radiation and then once daily for another eight consecutive days after irradiation. the eac mice receiving tce for the above regimen showed a dose-dependent ...200818803246
heavy metal accumulation in medicinal plants collected from environmentally different sites.to estimate the heavy metal content in soil and selected medicinal plants procured from environmentally different sites of the same city.200818837296
evidences for the involvement of monoaminergic and gabaergic systems in antidepressant-like activity of tinospora cordifolia in mice.the present study was taken up to investigate the effect of petroleum ether extract of tinospora cordifolia (wild.) miers, on depression in mice. the extract (50, 100 and 200 mg/kg, p.o.) was administered for 14 successive days to swiss young albino mice (either sex) and evaluated for antidepressant-like activity using tail suspension test and forced swim test. petroleum ether extract at all three doses produced significant antidepressant-like effect in tail suspension test as well as in forced ...200821369437
immunomodulatory effect of tinospora cordifolia extract in human immuno-deficiency virus positive patients.to assess the safety and efficacy of tce in human immuno-deficiency virus positive patients.200820040936
anti-tumor activity of four ayurvedic herbs in dalton lymphoma ascites bearing mice and their short-term in vitro cytotoxicity on dla-cell-line.the anti-tumor activity and chemopreventive potential of four ayurvedic herbs viz. curcuma longa l., ocimum sanctum l., tinospora cordifolia (wild) miers ex hook.f & thomas and zizyphus mauritiana lam. were evaluated using dalton lymphoma ascites (dla) tumor model in swiss albino mice. the outcome was assessed using survival time, peritoneal ascitic fluid (tumor volume) and hematological indices as parameters. animals were divided into five groups (n = 6) viz. one dla control and four herb + dla ...200820161965
the effects of spirulina on allergic rhinitis.the prevalence of allergic rhinitis is increasing globally due to various causes. it affects the quality life of a large group of people in all around the world. allergic rhinitis still remains inadequately controlled with present medical means. the need of continuous medical therapy makes individuals anxious about the side effects of the drugs. so there is a need for an alternative strategy. effects of spirulina, tinospora cordifolia and butterbur were investigated recently on allergic rhinitis ...200818343939
protective effect of tinospora cordifolia, phyllanthus emblica and their combination against antitubercular drugs induced hepatic damage: an experimental study.this study investigated the hepatoprotective effect of two indian medicinal plants tinospora cordifolia (tc), phyllanthus emblica (pe), and their combination, in a rat model of isoniazid, rifampicin and pyrazinamide induced hepatic damage. hepatic damage was assessed using a composite score assigned to histopathological findings of degeneration, necrosis and fibrosis. the antituberculosis treatment (att), when given for 90 days, induced significant degeneration and necrosis (score: 7.5; p < 0.01 ...200818389486
prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach.to evaluate the ability of curcuma longa (cl) and tinospora cordifolia (tc) formulation to prevent anti-tuberculosis (tb) treatment (att) induced hepatotoxicity.200818720535
indian herbs and herbal drugs used for the treatment of diabetes.traditional medicines derived from medicinal plants are used by about 60% of the world's population. this review focuses on indian herbal drugs and plants used in the treatment of diabetes, especially in india. diabetes is an important human ailment afflicting many from various walks of life in different countries. in india it is proving to be a major health problem, especially in the urban areas. though there are various approaches to reduce the ill effects of diabetes and its secondary complic ...200718398493
induction of caspase-3 activated dnase mediated apoptosis by hexane fraction of tinospora cordifolia in eat cells.tinospora cordifolia (guduchi) has been used for centuries for treating various ailments including cancer in ayurvedic system of medicine. in this study, we report the mechanism of cell death exhibited by the hexane extract fraction of t. cordifolia (tchf) against ehrlich ascites tumor (eat) in mice. treatment of eat bearing animals with tchf resulted in growth inhibition and induction of apoptosis in a dose-dependent manner. tchf induced the formation of apoptotic bodies, nuclear condensation, ...200721783760
screening of selected indian medicinal plants for acetylcholinesterase inhibitory activity.seventy-six plant extracts including methanolic and successive water extracts from 37 indian medicinal plants were investigated for acetylcholinesterase (ache) inhibitory activity (in vitro). results indicated that methanolic extracts to be more active than water extracts. the potent ache inhibiting methanolic plant extracts included withania somnifera (root), semecarpus anacardium (stem bark), embelia ribes (root), tinospora cordifolia (stem), ficus religiosa (stem bark) and nardostachys jatama ...200716950584
effect of tinospora cordifolia on gamma ray-induced perturbations in macrophages and splenocytes.tinospora cordifolia (rtc) has already been reported to protect whole-body lethally irradiated mice. this study has focussed on certain aspects of immuno-competence, which are adversely affected by irradiation. this study included estimation of spleen size, cell count, dna fragmentation and apoptosis in splenocytes. the adherence, spreading and phagocytic activities of macrophages were also assessed. cytokines in serum and anti-oxidants in plasma were also estimated. administration of rtc (200 m ...200717548939
effects of four indian medicinal herbs on isoniazid-, rifampicin- and pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs.to evaluate and compare the hepatoprotective and immunomodulatory effects of curcuma longa (cl), ocimum sanctum (os), tinospora cordifolia (tc) and zizyphus mauritiana (zm) on liver injury and immunosuppression induced by isoniazid (inh), rifampicin (rif) and pyrazinamide (pza).200717589898
antihyperglycaemic effect of 'ilogen-excel', an ayurvedic herbal formulation in streptozotocin-induced diabetes mellitus.'ilogen-excel', an ayurvedic herbal formulation is composed of eight medicinal plants (curcuma longa, strychnos potatorum, salacia oblonga, tinospora cordifolia, vetivelia zizanioides, coscinium fenestratum, andrographis paniculata and mimosa pudica). the present study evaluates the antihyperglycemic effect of 'ilogen-excel' in streptozotocin induced diabetic rats. rats were rendered diabetic by streptozotocin (stz) (45 mg/kg body weight). oral administration of 'ilogen-excel' (50 mg/kg and 100 ...200717665851
g1-4a, an immunomodulatory polysaccharide from tinospora cordifolia, modulates macrophage responses and protects mice against lipopolysaccharide induced endotoxic shock.pro-inflammatory cytokines are known to be the mediators of endotoxic shock and several immunomodulatory herbs can modulate the expression of these cytokines. therefore we have investigated the possibility of using an arabinogalactan polysaccharide, g1-4a, from the stem of tinospora cordifolia, for protection against endotoxin induced sepsis. there was 100% protection against lipopolysaccharide (lps) induced mortality in mice pretreated with g1-4a. to elucidate the mechanism of action, its effec ...200717673153
quantitative determination of four constituents of tinospora sps. by a reversed-phase hplc-uv-dad method. broad-based studies revealing variation in content of four secondary metabolites in the plant from different eco-geographical regions of india.this paper describes the separation and quantitation of important markers, such as 20beta-hydroxyecdysone, tinosporaside, cordioside, and columbin, present in three species of tinospora viz, t. cordifolia, t. malabrica, and t. crispa. a reverse-phase (rp) high-performance liquid chromatography (hplc)-uv-diode array detection (dad) method employing gradient elution is thus developed. the marker compounds isolated from 70% ethanolic extract of t. cordfolia by repeated column chromatography are ide ...200616959127
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