Publications

TitleAbstractYear(sorted descending)
Filter
PMID
Filter
effects of carriers, emulsifiers, and biopesticides for direct silk treatments on caterpillar feeding damage and ear development in sweet corn.in the northeastern united states, control of lepidopteran pests of sweet corn, particularly corn earworm [helicoverpa zea (boddie)], is difficult using organic methods. the direct application of corn oil and bacillus thuringiensis (bt) to corn silk has been shown to reduce ear damage from corn earworm in past studies; these studies sought to optimize this method by evaluating additional carrier and biopesticide mixtures that comply with the united states federal insecticide, fungicide, and rode ...201728073976
antibacterial efficacy of azadirachta indica, mimusops elengi and 2% chx on multispecies dentinal biofilm.to check the antimicrobial activity of azadirachta indica (neem), mimusops elengi (bakul), and chlorhexidine gluconate (chx) on multispecies biofilm of common endodontic pathogens such as streptococcus mutans, enterococcus faecalis, staphylococcus aureus and candida albicans.201726752840
insecticidal effects of deltamethrin in laboratory and field populations of culicoides species: how effective are host-contact reduction methods in india?bluetongue virus (btv) is transmitted by culicoides biting midges and causes bluetongue (bt), a clinical disease observed primarily in sheep. bt has a detrimental effect on subsistence farmers in india, where hyperendemic outbreaks impact on smallholdings in the southern states of the country. in this study, we establish a reliable method for testing the toxic effects of deltamethrin on culicoides and then compare deltamethrin with traditional control methods used by farmers in india.201728143560
in silico evaluation of inhibitory potential of triterpenoids from azadirachta indica against therapeutic target of dengue virus, ns2b-ns3 protease.ns2b-ns3 protease (ns2b-ns3 pro ) of dengue virus (denv) is the prime therapeutic target for the development of anti-dengue drug to combat the denv infection, which is currently an increasing health problem in many countries. in the area of antiviral drug discovery, numerous reports on the antiviral activity of various medicinal plants against dengue viruses have been published. neem plant (azadirachta indica) is one among those medicinal plants which is reported to show potential antiviral acti ...201727353586
comparative evaluation of antimicrobial effect of herbal root canal irrigants (morinda citrifolia, azadirachta indica, aloe vera) with sodium hypochlorite: an in vitro study.successful root canal treatment involves the complete elimination of microorganism from the root canal and the three-dimensional obturation of the canal space. enterococcus faecalis is the most commonly found bacteria in failed root canal. chemical irrigation of canals along with biomechanical preparation helps in the elimination of microorganisms. the present study was aimed to evaluate the antimicrobial effect of herbal root canal irrigants (morinda citrifolia, azadirachta indica extract, aloe ...201727382533
biofilm forming capacity of enterococcus faecalis on gutta-percha points treated with four disinfectants using confocal scanning laser microscope: an in vitro study.the aim of this study was to evaluate and compare the in vitro biofilm forming capacity of enterococcus faecalis on gutta-percha points disinfected with four disinfectants.201726288622
chemical profile and defensive function of the latex of euphorbia peplus.plant latex is an endogenous fluid secreted from highly specialized laticifer cells and has been suggested to act as a plant defense system. the chemical profile of the latex of euphorbia peplus was investigated. a total of 13 terpenoids including two previously unknown diterpenoids, (2s*,3s*,4r*,5r*,6r*,8r*,l1r*,13s*,14s*,15r*, 16r*)-5,8,15-triacetoxy-3-benzoyloxy-11,16-dihydroxy-9-oxopepluane and (2r*,3r*, 4s*,5r*,7s*,8s*,9s*,l3s*,14s*,15r*)-2,5,8,9,14-pentaacetoxy-3-benzoyloxy-15-hydroxy-7-is ...201728062071
beneficial effects of a coriolus versicolor-based vaginal gel on cervical epithelization, vaginal microbiota and vaginal health: a pilot study in asymptomatic women.to assess the effect of a 12-day treatment using a vaginal gel based on niosomes containing hyaluronic acid, ß-glucan, alpha-glucan oligosaccharide, coriolus versicolor, asian centella, azadirachta indica and aloe vera on vaginal microbiota, cervical epithelization and vaginal health.201728302110
herbal extracts in oral health care - a review of the current scenario and its future needs.oral diseases are among the major public health problems and the commonest of chronic diseases that affect mankind. the application of natural products for the control of oral diseases is considered as an interesting alternative to synthetic antimicrobials due to their lower negative impact, and for the effort to overcome primary or secondary resistance to the drug during therapy.201726392704
comparison of efficacy of herbal disinfectants with chlorhexidine mouthwash on decontamination of toothbrushes: an experimental trial.toothbrushes in regular use can become heavily contaminated with microorganisms, which can cause infection or reinfection. there is a need for toothbrush disinfection methods, which are rapidly effective, cost-effective, nontoxic, and that can be easily implemented.201727011928
management of blight of bell pepper (capsicum annuum var. grossum) caused by drechslera bicolor.sweet or bell pepper is a member of the solanaceae family and is regarded as one of the most popular and nutritious vegetable. blight, in the form of leaf and fruit blight, has been observed to infect bell pepper crops cultivated at the horticulture farm in rajasthan college of agriculture, udaipur, india. based on disease severity, we attempted to curb this newly emerged problem using different fungicides, plant extracts, bio-control agents, and commercial botanicals against the fungus in labor ...201727613104
chemopreventive effect of methanolic extract of azadirachta indica on experimental trypanosoma brucei induced oxidative stress in dogs.the medicinal properties of azadirachta indica have been harnessed for many years in the treatment of many diseases in both humans and animals.201726130936
antibacterial function of herbal extracts on growth, survival and immunoprotection in the black tiger shrimp penaeus monodon.this study examined the effects of an herbal extract composed of nine herbs i.e aloe vera, andrographis pariculata, annona squamosa, azadirachta indica, citrus aurantifolia, coriandrum sativum, ocimum sanctum, ollium cepa and psidium guajava on growth, survival rate and immunoprotection against pathogenic vibrio harveyi in the tiger shrimp penaeus monodon. the petroleum ether, methanol and n-hexen extracts of different herbal plants were selected, processed and thoroughly mixed in equal proporti ...201728365386
neem (azadirachta indica): towards the ideal insecticide?pesticide resistance is going to change rapidly our antibiotics and insecticides arsenal. in this scenario, plant-derived natural products are considered valuable candidates to reverse this negative trend. growing research attention is focused on neem (azadirachta indica, meliaceae), exploring the utility of its products as insecticides and antibiotics. in this review, we summarised the knowledge on neem oil and neem cake by-products in arthropod pest control, with special reference to mosquito ...201727687478
neem cake as a promising larvicide and adulticide against the rural malaria vector anopheles culicifacies (diptera: culicidae): a hptlc fingerprinting approach.mosquitoes are insects of huge public health importance, since they act as vectors for important pathogens and parasites. here, we focused on the possibility of using the neem cake in the fight against mosquito vectors. the neem cake chemical composition significantly changes among producers, as evidenced by our hptlc (high performance thin layer chromatography) analyses of different marketed products. neem cake extracts were tested to evaluate the ovicidal, larvicidal and adulticidal activity a ...201727552943
emulsion of chloramphenicol: an overwhelming approach for ocular delivery.ophthalmic formulations of chloramphenicol have poor bioavailability of chloramphenicol in the ocular cavity.201728384103
nimbolide induces apoptosis in human nasopharyngeal cancer cells.nasopharyngeal carcinoma (npc), a tumor arising from epithelial cells that cover the surface and line the nasopharynx, is a rare malignancy worldwide but is prevalent in certain geographical areas, such as southern asia (taiwan, hong kong, singapore, malaysia, and southern china) and north africa. despite advances in diagnostic techniques and improvements in treatment modalities, the prognosis of npc remains poor. therefore, an effective chemotherapy regimen that enhances tumor sensitivity to ch ...201728383207
the effects of neem oil (azadirachta indica a. juss) enriched with different concentrations of azadirachtin on the integument of semi-engorged rhipicephalus sanguineus sensu lato (acari: ixodidae) females.several studies searching for methods to control rhipicephalus sanguineus s.l., (dog tick) infestations have been developed aiming to minimize the damages caused by these ectoparasites to the hosts and the environment, which is harmed by the indiscriminate use of toxic acaricide products. in this scenario, neem oil has been used as a natural alternative against ticks, once this chemical has repellent properties and interferes in the growth regulation of these ectoparasites, inhibiting ecdysis. t ...201728370810
transcriptomics and proteomic studies reveal acaricidal mechanism of octadecanoic acid-3, 4 - tetrahydrofuran diester against sarcoptes scabiei var. cuniculi.in our previous study, a new compound, octadecanoic acid-3, 4-tetrahydrofuran diester, possessing potent acaricidal activity was obtained from neem oil. this study performed rna-seq transcriptomics and itraq proteomics to uncover the acaricidal mechanism of the compound against sarcoptes scabiei var. cuniculi. the results of transcriptomics indicated that after treatment with octadecanoic acid-3, 4-tetrahydrofuran diester, genes related to "energy metabolism" were significantly up-/down-regulate ...201728361965
in vitro antioxidant and antidiabetic activities of zinc oxide nanoparticles synthesized using different plant extracts.phytofabricated green synthesis of zinc oxide (zno) nanoparticles using different plant extracts of azadirachta indica, hibiscus rosa-sinensis, murraya koenigii, moringa oleifera, and tamarindus indica for biological applications has been reported. zno nanoparticles were also synthesized by chemical method to compare the efficiency of the green synthesized nanoparticles. ft-ir spectra confirmed the functional groups involved in the green synthesis of zno nanoparticles and the powder xrd patterns ...201728361361
ultrastructural changes in raillietina (platyhelminthes: cestoda), exposed to sulfonoquinovosyldiacylglyceride (sqdg), isolated from neem (azadirachta indica).neem (azadirachta indica), has been known to be a curative for various ailments and diseases in the traditional indian medicinal system from times immemorial. a glycolipid sulfonoquinovosyldiacylglyceride (sqdg) isolated from the leaves of neem has been found to be a proactive antibacterial and antiviral agent in previous studies. the current communication pertains to the anthelmintic activity of sqdg in vitro against a model cestode raillietina spp. the results of efficacy tests showed a paraly ...201728347172
enhanced hplc-dad method for fast determination of quercetin-3-o-β-d-glucoside in extracts and polyherbal formulations containing azadirachta indica-optimization and validation.azadirachta indica has been used for its medicinal properties since time immemorial. herbal medicines which are prepared using this medicinal tree are utilized to treat various diseases and disorders. no reports are available for marker-based standardization of these herbal medicines prepared from leaves of a. indica. also existing hplc methods for determination quercetin-3-o-β-d-glucoside are time consuming. there is an obvious need for development of new hplc method for quantification of querc ...201728334842
topical application of neem leaves prevents wrinkles formation in uvb-exposed hairless mice. 201728319870
in vitro evaluation of antifilarial effect of azadirachta indica leaves extract in different solvents on the microfilariae of setaria cervi.polar solvent extracts of azadirachta indica leaves were investigated to evaluate in vitro anthelmintic activity on the microfilariae of setaria cervi. four extracts of a. indica leaves were prepared with different solvents in increasing order of polarity (diethyl ether < chloroform < ethanol < methanol). stock solution of the extract of a. indica leaves was prepared in ringer's solution at the concentrations of 50, 100 and 200 μg/ml and used against microfilariae in three replicates. ringer's s ...201728316381
lethal and sublethal effects of pesticides in the management of polyphagotarsonemus latus (banks) (acari: tarsonemidae) on capsicum annuum l.the evaluation of lethal and sublethal effects are of great importance for a complete assessment of the total impact of chemical compounds upon pest populations and the development of management strategies. at this study, the lethal and sublethal effects of different synthetic and botanical products were evaluated upon the broad mite, polyphagotarsonemus latus (banks), a major pest of capsicum annuum l and other crops.201728296187
evaluation of antioxidant and anticancer activity of copper oxide nanoparticles synthesized using medicinally important plant extracts.copper oxide (cuo) nanoparticles were synthesized by green chemistry approach using different plant extracts obtained from the leaves of azadirachta indica, hibiscus rosa-sinensis, murraya koenigii, moringa oleifera and tamarindus indica. in order to compare their efficiency, the same copper oxide nanoparticles was also synthesized by chemical method. phytochemical screening of the leaf extracts showed the presence of carbohydrates, flavonoids, glycosides, phenolic compounds, saponins, tannins, ...201728292015
a new azadirachta from the crude extracts of neem (azadirachta indica a. juss) seeds.one new compound, 2h, 3h-cyclopent[b] furo [2',3':4,5] naphtho [2,4-d] heptlactone-[3,7] furan-6aceticacid, 3-(acetyloxy)-8-(3-furyl)-2a, 4a, 4b, 4c,5,5a, 6, 6a, 8, 9,9a, 10a,10b-13 hydrogen-2a,5a,6a,5-tetramethyl-3-[[(2e)-2-methyl-1-oxo-2-butenyl]oxy]-methyl ester, named azadirachta r (1), along with 10 known ones, azadirachta a, az-b, az-d, az-h, az-i, nimbin, deacetylnimbin, salannin, deacetylsalannin and azadiradione were isolated from the crude extracts of neem (azadirachta indica a. juss) ...201728278641
in vitro evaluation of acaricidal activity of novel green silver nanoparticles against deltamethrin resistance rhipicephalus (boophilus) microplus.an investigation was undertaken to study, for the first time, in vitro acaricidal activity of green silver nanoparticles on deltamethrin resistance rhipicephalus (boophilus) microplus. the compounds tested were neem coated silver nanoparticles (n-ag nps), deltamethrin neem coated silver nanoparticles (dn-ag nps), 2, 3 dehydrosalannol (2,3 dhs), 2, 3 dhs coated silver nanoparticles (2, 3-dhs-ag nps), quercetin dihydrate (qdh) and qdh coated silver nanoparticles (qdh-ag nps). also included in this ...201728246003
synthesis of chitosan incorporated neem seed extract (azadirachta indica) for medical textiles.in present study, eco-friendly biosynthesis of chitosan-neem seed (cs-ns) composite was prepared by co-precipitation method using aqueous neem seed extract. cotton fabrics were treated with two different crosslinking agents (glutaraldehyde and citric acid) then the synthesized composite coated on cotton fabric by chemical linkage between the composite and the cellulose structure. as synthesized composite materials and treated cotton fabrics were characterized by fourier transform infrared spectr ...201728242332
neem oil (azadirachta indica a. juss) affects the ultrastructure of the midgut muscle of ceraeochrysa claveri (navás, 1911) (neuroptera: chrysopidae).cytomorphological changes, by means of ultrastructural analyses, have been used to determine the effects of the biopesticide neem oil on the muscle fibers of the midgut of the predator ceraeochrysa claveri. insects, throughout the larval period, were fed eggs of diatraea saccharalis treated with neem oil at a concentration of 0.5%, 1% or 2%. in the adult stage, the midgut was collected from female insects at two stages of adulthood (newly emerged and at the start of oviposition) and processed fo ...201727939524
preconditioning with azadirachta indica ameliorates cardiorenal dysfunction through reduction in oxidative stress and extracellular signal regulated protein kinase signalling.azadirachta indica is widely distributed in africa, asia and other tropical parts of the world. a. indica (ai) is traditionally used for the treatment of several conditions including cancer, hypertension, heart diseases and skin disorders. intestinal ischaemia-reperfusion is a common pathway for many diseases and may lead to multiple organ dysfunction syndrome and death.201727894590
chitosan immobilized novel peroxidase from azadirachta indica: characterization and application.in the present paper, a peroxidase was purified from the leaves of a medicinal tree, namely azadirachta indica, to 45.2 folds with overall recovery of 61%. based on the subunit size, the purified peroxidase was suggested to be a monomeric structure of size 50kda and exhibited good thermostability as it was fully stable at 65°c for 1hr and also retained about 73% activity at 70°c till 30min. the substrate affinity was found to be in order of guaiacol>pyrogallol>o-dianisidine. the purified peroxid ...201728215563
oral (systemic) botanical agents for the treatment of psoriasis: a review.patients with psoriasis often use botanical therapies as part of their treatment. it is important for clinicians to be aware of the current evidence regarding these agents as they treat patients.201728157393
nitric oxide production-inhibitory activity of limonoids from azadirachta indica and melia azedarach.seventy-three limonoids isolated from three meliaceae plants, azadirachta indica, a. indica var. siamensis, and melia azedarach, or semi-synthesized from the meliaceae limonoids, were evaluated for their inhibitory activity against nitric oxide (no) production in mouse macrophage raw 264.7 cells induced by lipopolysaccharide (lps), as a primary screening test for anti-inflammatory agents. of the compounds tested, 21 compounds exhibited inhibitory activity (ic50 4.6-58.6 μm) without any significa ...201728145090
management of acute skin toxicity with hypericum perforatum and neem oil during platinum-based concurrent chemo-radiation in head and neck cancer patients.acute skin toxicity is a frequent finding during combined radiotherapy and chemotherapy in head and neck cancer patients. its timely and appropriate management is crucial for both oncological results and patient's global quality of life. we herein report clinical data on the use of hypericum perforatum and neem oil in the treatment of acute skin toxicity during concurrent chemo-radiation for head and neck cancer. a consecutive series of 50 head and neck cancer patients undergoing concomitant rad ...201728101834
stabilization of neem oil biodiesel with corn silk extract during long-term storage.the current study aimed to evaluate the antioxidant efficiency of different extracts of corn silk. in addition, the impact of corn silk extract on oxidative stability of neem biodiesel during storage was studied. the highest phenolics, dpph radical scavenging and reducing power activities were recorded for methanol-water extract. the longest oxidation stability (10 h) was observed for biodiesel samples blended with 1000 ppm of corn silk extract (cse). at the end of storage period the induction t ...201728100884
comparison of two adsorbent based de-bittering procedures for neem (azadirachta indica a. juss) tea- effect on polyphenols, anti-oxidant capacity, color and volatile profile.bitterness reduction, especially of foods and beverages containing phytonutrients, is one of the biggest challenges in the food industry because bitterness has a deleterious effect on the taste profile of foods and beverages. neem (azadirachta indica a. juss) is a medicinal tree, indigenous to the indian-subcontinent, whose medicinal properties have led to it being heralded as the tree which is the "panacea for all diseases". however, neem leaf is extremely bitter, in large part due to its limon ...201728091970
the first chloroplast genome sequence of boswellia sacra, a resin-producing plant in oman.boswellia sacra (burseraceae), a keystone endemic species, is famous for the production of fragrant oleo-gum resin. however, the genetic make-up especially the genomic information about chloroplast is still unknown. here, we described for the first time the chloroplast (cp) genome of b. sacra. the complete cp sequence revealed a circular genome of 160,543 bp size with 37.61% gc content. the cp genome is a typical quadripartite chloroplast structure with inverted repeats (irs 26,763 bp) separated ...201728085925
can toxicants used against cotton mealybug phenacoccus solenopsis be compatible with an encyrtid parasitoid aenasius bambawalei under laboratory conditions?the cotton mealybug, phenacoccus solenopsis tinsley (sternorrhyncha: pseudococcidae) is a serious pest of various cultivated plants in pakistan. recent reports show that the parasitoid aenasius bambawalei hayat (hymenoptera: encyrtidae) is a good biocontrol agent of the pest. compatibleness is important in any ipm programme, and the insecticide used must have little or no effects on the biological control agent. this study investigated the compatibility of neem treatments and a commercial insect ...201728063085
analysis of anti-bacterial and anti oxidative activity of azadirachta indica bark using various solvents extracts.herbal medications have been used for relief of symptoms of disease. regardless of the great advances observed in current medicine in recent decades, plants still make a significant contribution to health care. an alarming increase in bacterial strains resistant to a number of antimicrobial agents demands that a renewed effort be made to seek antibacterial agents effective against pathogenic bacteria resistant to or less sensitive to current antibiotics. anti-bacterial activity of azadirachta in ...201728053565
insights on germinability and desiccation tolerance in developing neem seeds (azadirachta indica): role of aos, antioxidative enzymes and dehydrin-like protein.the germinability and desiccation tolerance (dt) in developing seed are regulated by cellular metabolism involving active oxygen species (aos) and protective proteins during maturation drying. the aim of the present investigation was to unravel the functions of aos (superoxide, h2o2 and oh-radical), antioxidative enzymes (sod, cat and apx) and dehydrin-like proteins in regulating the germinability and dt in undried and artificially desiccated developing neem seeds. germination was first observed ...201728040634
neem tree (azadirachta indica) extract specifically suppresses the growth of tumors in h22-bearing kunming mice.recently, neem tree (azadirachta indica) extract (nte) has been reported to have various antitumor activities against gastric, breast, prostate, and skin cancer, respectively. the current study was designed to evaluate the effect of nte on hepatic cancer in a mouse model. the possible side effects elicited by nte were also evaluated. the components in nte were analyzed by liquid chromatography-mass spectrometry (lc-ms). h22 cells-bearing kumming mice were generated by injecting h22 cells subcuta ...201727248120
insecticidal activity of neem oil against gyropsylla spegazziniana (hemiptera: psyllidae) nymphs on paraguay tea seedlings.gyropsylla spegazziniana (paraguay tea ampul) is one of the most important pests of paraguay tea plants, and prohibition of synthetic insecticide use for control of this pest has led to the search for alternative methods. this laboratory study aimed to compare different control strategies for g. spegazziniana, utilizing a commercial neem seed oil product. paraguay tea seedlings were treated with neem oil solution both pre- and post-infestation with 5th instar nymphs. the systemic action of neem ...201727143053
selectivity of plant extracts for trichogramma pretiosum riley (hym.: trichogrammatidae).we evaluated the selectivity of three plant extracts with potential insecticidal effects for the parasitoid trichogramma pretiosum riley, which is commonly used in biological pest control. the plant extracts assayed were an acetone extract of toona ciliata m. roem., commercial neem oil, and a nanoencapsulated formulation of neem oil (nc40). the toxicity of the plant extracts to t. pretiosum was evaluated according to the recommendations of the international organization for biological control- i ...201728012368
synthesis and characterization of seaweed cellulose derived carboxymethyl cellulose.in the present study, cellulose (swc) extracted from green seaweed ulva fasciata was processed to synthesize carboxymethyl cellulose (swcmc). the seaweed cellulose (∼15% dw) was first processed for α cellulose extraction (10.1% on dw) followed by the synthesis and characterization of swcmc. thin films were prepared using commercial cmc (ccmc), swcmc and swcmc-metal nanoparticle (2% wt/v) by solvent evaporation technique. films were studied for molecular weight, degree of carboxylation, viscosity ...201727987874
in vivo antimicrobial efficacy of 6% morinda citrifolia, azadirachta indica, and 3% sodium hypochlorite as root canal irrigants.to evaluate and compare the antimicrobial efficacy of 6% morinda citrifolia, azadirachta indica, and 3% sodium hypochlorite (naocl) as root canal irrigants.201726929692
effectiveness of azadirachta indica (neem) mouthrinse in plaque and gingivitis control: a systematic review.the aim of this systematic review was to evaluate the effectiveness of azadirachta indica (neem)-based herbal mouthrinse in improving plaque control and gingival health.201726876277
molecular approach to identify antidiabetic potential of azadirachta indica.azadirachta indica (neem) is a medicinal plant, used in ayurveda for treating various diseases, one of which is diabetes mellitus. it is known to possess antiinflammatory, antipyretic, antimicrobial, antidiabetic and diverse pharmacological properties. however, the molecular mechanism underlying the effect of a. indica on insulin signal transduction and glucose homeostasis is obscure.201726604551
improvement of sperm density in neem-oil induced infertile male albino rats by ipomoea digitata linn.investigation has been carried out to validate folkloric claim of the potential of ipomoea digitata (id) based on reproductive health status in experimentally induced male albino rats.201726401398
effect of neem oil and haridra on non-healing wounds.in ayurveda, vrana (wound) has stated as tissue destruction and discoloration of viable tissue due to various etiology. in sushruta samhita, sushruta described vrana as a main subject. most commonly vrana can be classified into shuddha and dushta vrana (chronic wound/nonhealing ulcers). among the various drugs mentioned for dushta vrana, two of them, neem (azadirechta indica a. juss) oil and haridra (curcuma longa linn.) powder are selected for their wide spectrum action on wound.201726195902
azadirachta indica: a herbal panacea in dentistry - an update.azadirachta indica commonly known as neem, is an evergreen tree. since time immemorial it has been used by indian people for treatment of various diseases due to its medicinal properties. it possesses anti-bacterial, anti-cariogenic, anti-helminthic, anti-diabetic, anti-oxidant, astringent, anti-viral, cytotoxic, and anti-inflammatory activity. nimbidin, azadirachtin and nimbinin are active compounds present in neem which are responsible for antibacterial activity. neem bark is used as an active ...201726009692
azadirachta indica attenuates cisplatin-induced neurotoxicity in rats.the objective of this study is to investigate the neuroprotective effects of azadirachta indica leaves against cisplatin (cp)-induced neurotoxicity.201724987180
gedunin abrogates aldose reductase, pi3k/akt/mtor, and nf-κb signaling pathways to inhibit angiogenesis in a hamster model of oral carcinogenesis.aberrant activation of oncogenic signaling pathways plays a central role in tumor development and progression. the aim of this present study was to investigate the chemopreventive effects of the neem limonoid gedunin in the hamster model of oral cancer based on its ability to modulate aldose reductase (ar), phosphatidyl inositol-3-kinase (pi3k)/akt, and nuclear factor kappa b (nf-κb) pathways to block angiogenesis. administration of gedunin suppressed the development of hbp carcinomas by inhibit ...201626342697
selectivity of neem to trichogramma pretiosum riley and trichogrammatoidea annulata de santis (hymenoptera: trichogrammatidae).trichogramma pretiosum riley and trichogrammatoidea annulata de santis are commonly found in avocado and persimmon orchards in northern parana state. however, their abundance depends on whether insecticides are used or not to control the key lepidopteran pests stenoma catenifer (wals.) (lepidoptera: elachistidae) and hypocala andremona (stoll) (lepidoptera: noctuidae), respectively. the aim of this work was to evaluate the effects of an aqueous neem seed extract (anse) at 15, 3 and 1.5%, and of ...201621271068
[reduced survival and infestation of coffee borer, hypothenemus hampei (ferrari) (coleoptera: scolytidae), on coffee fruits, in response to neem sprays in laboratory].aqueous solutions of neem oil and aqueous extracts of neem seeds and leaves were sprayed on coffee fruits for laboratory evaluation of their efficiency in reducing infestation of the coffee borer, hypothenemus hampei (ferrari), in multi-choice preference assays in laboratory. neem oil and extracts reduced infestation of fruits in a dose-dependent manner, acting as a repellent. at 0.5%, 1% and 1.5%, the oil reduced fruit infestation by 30.2%, 42.5% (p > 0.05), and 58.6% (p < 0.05), respectively, ...201620878003
[in vitro insecticidal activity of seed neem oil on lutzomyia longipalpis (diptera: psychodidae)].lutzomyia longipalpis is the main vector of visceral leishmaniasis in brazil. the objective was to evaluate the effect of oil from (azadirachta indica) neem seeds on eggs, larvae and adults of the vector. the insects were captured in the field and kept in the laboratory at +/- 27 °c and 80% relative humidity. five treatments with different concentrations were performed using two negative controls (distilled water and tween 80) and a positive control. the eggs were sprayed with the oil at differe ...201620385053
neem oil: an herbal therapy for alopecia causes dermatitis.for more than 2,000 years, the neem tree has been considered one of the most useful and versatile plants in the world. neem oil has been used for both homeopathic remedies and as a pesticide. both systemic and contact reactions have occurred with the use of neem oil. we report a patient who presented with an acute case of contact dermatitis on the scalp and face after the use of neem oil for alopecia and present a review of the literature regarding its uses, toxicity, and regulation.201618627678
effect of initial temperature treatment on phytochemicals and antioxidant activity of azadirachta indica a. juss.the present study was undertaken to evaluate the effect of initial temperature treatment on phytochemical and antioxidant potential of commercially important plant azadirachta indica a. juss. the leaves were differentially treated after harvest at temperatures 4, -20, and 110 °c and at room temperature, separately. it was found that a quick drying process at 110 °c followed by air-drying helped in maximum retention of bioactive compounds and antioxidant activity, which was significantly higher t ...201626467740
in vitro screening of natural feed additives from crustaceans, diatoms, seaweeds and plant extracts to manipulate rumen fermentation.eight natural products from animal, unicellular algae, brown seaweed and plant origins were chosen according to their theoretical antimicrobial activity: diatomaceous earths (de), insoluble chitosan (ichi), soluble chitosan (chi), seaweed meal (swm), ascophyllum nodosum (asc), laminaria digitata (lam), neem oil (noil) and an ivy fruit extract rich in saponins (ivy). dose-response incubations were conducted to determine their effect on rumen fermentation pattern and gas production, while their an ...201626441121
steroidal glycoalkaloids: chemical defence of edible african nightshades against the tomato red spider mite, tetranychus evansi (acari: tetranychidae).tetranychus evansi is an invasive pest of solanaceous crops in africa, and in the field it differentially attacks edible african nightshades. the chemical basis for the differential attack on these plant species is largely unknown. using bioassays and chemical analysis, we investigated the differential bioactivity of leaf extracts of three edible african nightshade species, solanum sarrachoides, s. scabrum and s. villosum, on adult t. evansi females.201626299255
blue emitting zno nanostructures grown through cellulose bio-templates.this paper presents a green and cost-effective recipe for the synthesis of blue-emitting zno nanoparticles (nps) using cellulose bio-templates. azadirachta indica (neem) leaf extract prepared in different solvents were used as biological templates to produce nanostructures of wurtzite zno with a particle size ~12-36 nm. a cellulose-driven capping mechanism is used to describe the morphology of zno nps. the scanning electron microscopy (sem), transmission electron microscopy (tem), x-ray diffract ...201626597927
effect of feeding neem (azadirachta indica) and acacia (acacia senegal) tree foliage on nutritional and carcass parameters in short-eared somali goats.the study was conducted to determine the effects of dried foliage of acacia senegal and neem (azadirachta indica) tree supplementations on feed intake, nutrient digestibility, growth, and carcass parameters in short-eared somali goats. twenty male intact short-eared somali goat yearlings with an average live weight of 16.2 ± 1.08 (mean ± sd) were assigned to four treatment groups, which comprised a basal diet of hay alone (t1) and supplementation with the tree foliages. supplements consisted nee ...201626563272
ultrasound-assisted extraction of azadirachtin from dried entire fruits of azadirachta indica a. juss. (meliaceae) and its determination by a validated hplc-pda method.azadirachta indica a. juss., also known as neem, is a meliaceae family tree from india. it is globally known for the insecticidal properties of its limonoid tetranortriterpenoid derivatives, such as azadirachtin. this work aimed to optimize the azadirachtin ultrasound-assisted extraction (uae) and validate the hplc-pda analytical method for the measurement of this marker in neem dried fruit extracts. box-behnken design and response surface methodology (rsm) were used to investigate the effect of ...201626717816
nimbolide-induced oxidative stress abrogates stat3 signaling cascade and inhibits tumor growth in transgenic adenocarcinoma of mouse prostate model.prostate cancer (pca) is one of the most commonly diagnosed cancers worldwide. currently available therapies for metastatic pca are only marginally effective, hence novel treatment modalities are urgently required. considerable evidence(s) suggest that deregulated activation of oncogenic transcription factor, signal transducer and activator of transcription 3 (stat3) plays a pivotal role in the development and progression of pca. thus, agents that can abrogate stat3 activation could form the bas ...201626649526
azadirachtin(a) distinctively modulates subdomain 2 of actin - novel mechanism to induce depolymerization revealed by molecular dynamics study.azadirachtin(a) (aza), a potential insecticide from neem, binds to actin and induces depolymerization in drosophila. aza binds to the pocket same as that of latrunculin a (lat), but lat inhibits actin polymerization by stiffening the actin structure and affects the adp-atp exchange. the mechanism by which aza induces actin depolymerization is not clearly understood. therefore, different computational experiments were conducted to delineate the precise mechanism of aza-induced actin depolymerizat ...201626646738
cytotoxic effects of neem oil in the midgut of the predator ceraeochrysa claveri.studies of morphological and ultrastructural alterations in target organs have been useful for evaluating the sublethal effects of biopesticides regarded as safe for non-target organisms in ecotoxicological analyses. one of the most widely used biopesticides is neem oil, and its safety and compatibility with natural enemies have been further clarified through bioassays performed to analyze the effects of indirect exposure by the intake of poisoned prey. thus, this study examined the cellular res ...201626520254
the bioefficacy of crude extracts of azadirachta indica (meliaceae) on the survival and development of myiasis-causing larvae of chrysomya bezziana (diptera: calliphoridae).myiasis is a type of parasitosis originating from the invasion of tissues of live humans and other vertebrates by dipteran larvae. the old world screwworm fly—chrysomya bezziana—is known worldwide in the tropical regions for causing myiasis among man and domestic animals, thereby leading to health hazards and severe economic losses to the dairy farmers. management techniques for controlling populations of the fly are needed to minimize these losses. plant-derived materials have been increasingly ...201626494546
desacetyl nimbinene inhibits breast cancer growth and metastasis through reactive oxygen species mediated mechanisms.accumulation of reactive oxygen species (ros) has been implicated in induction of apoptosis and regulation of key signaling molecules in cancer cells. phytochemicals are potent source of anticancer drugs as wells as potential inducers of ros. neem (azadirachta indica) is a medicinal plant used for the treatment of various diseases. the main objective of this study is to investigate the anticancer effect of desacetyl nimbinene (dan; an active ingredient of neem) against breast cancer. normal and ...201626637227
mechanism of neem limonoids-induced cell death in cancer: role of oxidative phosphorylation.we have previously reported that neem limonoids (neem) induce multiple cancer cell death pathways. here we dissect the underlying mechanisms of neem-induced apoptotic cell death in cancer. we observed that neem-induced caspase activation does not require bax/bak channel-mediated mitochondrial outer membrane permeabilization, permeability transition pore, and mitochondrial fragmentation. neem enhanced mitochondrial dna and mitochondrial biomass. while oxidative phosphorylation (oxphos) complex-i ...201626627937
morphological alterations in salivary glands of rhipicephalus sanguineus ticks (acari: ixodidae) exposed to neem seed oil with known azadirachtin concentration.neem (azadirachta indica) has attracted the attention of researchers worldwide due to its repellent properties and recognized effects on the morphology and physiology of arthropods, including ticks. therefore, this study aimed to demonstrate the effects of neem seed oil enriched with azadirachtin on salivary glands of rhipicephalus sanguineus ticks, targets of great veterinary interest because of their ability to transmit pathogens to dogs. for this, r. sanguineus semi-engorged females were subj ...201626852009
neem leaf glycoprotein promotes dual generation of central and effector memory cd8(+) t cells against sarcoma antigen vaccine to induce protective anti-tumor immunity.we have previously shown that neem leaf glycoprotein (nlgp) mediates sustained tumor protection by activating host immune response. now we report that adjuvant help from nlgp predominantly generates cd44(+)cd62l(high)ccr7(high) central memory (tcm; in lymph node) and cd44(+)cd62l(low)ccr7(low) effector memory (tem; in spleen) cd8(+) t cells of swiss mice after vaccination with sarcoma antigen (sarag). generated tcm and tem participated either to replenish memory cell pool for sustained disease f ...201626851529
knowledge, attitude, and practice regarding cervical cancer among rural community women in northeast thailand.cervical cancer is the second most common malignancy among women worldwide, and women of reproductive age in thailand. however, information on the behavior regarding cervical cancer in rural community thailand is sparse.201626838259
nimbolide inhibits pancreatic cancer growth and metastasis through ros-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition.the mortality and morbidity rates of pancreatic cancer are high because of its extremely invasive and metastatic nature. its lack of symptoms, late diagnosis and chemo-resistance and the ineffective treatment modalities warrant the development of new chemo-therapeutic agents for pancreatic cancer. agents from medicinal plants have demonstrated therapeutic benefits in various human cancers. nimbolide, an active molecule isolated from azadirachta indica, has been reported to exhibit several medici ...201626804739
nimbolide, a neem limonoid inhibits phosphatidyl inositol-3 kinase to activate glycogen synthase kinase-3β in a hamster model of oral oncogenesis.glycogen synthase kinase-3β (gsk-3β), a serine/threonine kinase is frequently inactivated by the oncogenic signalling kinases pi3k/akt and mapk/erk in diverse malignancies. the present study was designed to investigate gsk-3β signalling circuits in the 7,12-dimethylbenz[a]anthracene (dmba)-induced hamster buccal pouch (hbp) carcinogenesis model and the therapeutic potential of the neem limonoid nimbolide. inactivation of gsk-3β by phosphorylation at serine 9 and activation of pi3k/akt, mapk/erk ...201626902162
designing and screening of universal drug from neem (azadirachta indica) and standard drug chemicals against influenza virus nucleoprotein.different strains of influenza virus are affecting a large number of people worldwide. many synthetic antiviral medicines are available for influenza virus in the market. but still there is a need for the development of universal drugs against these strains of influenza virus.201627986088
natural agents used in chemoprevention of aerodigestive and gi cancers.aerodigestive cancers are on an increasing level in both occurrence and mortality. a major cause in many of these cancers is disruption of the inflammatory pathway, leading to increased cell proliferation, and epigenetic silencing of normal regulatory genes. here we review the research on several natural products: silibinin, silymarin, quercetin, neem & nimbolide, gingerol, epigallatecatechin-3- gallate, curcumin, genistein and resveratrol conducted on aerodigestive cancers. these types of cance ...201627134816
use of plant extracts for tea pest management in india.india is the second largest producer of black tea in the world. the biggest challenge for tea growers of india nowadays is to combat pests and diseases. tea crop in india is infested by not less than 720 insect and mite species. at least four sucking pests and six chewing pests have well established themselves as regular pests causing substantial damage to this foliage crop. various synthetic pesticides are widely used for the management of tea pests in india. applications of such large quantity ...201627102124
lack of genotoxic potential of pesticides, spinosad, imidacloprid and neem oil in mice (mus musculus).pesticides, spinosad, imidacloprid and neem oil are widely used both in residential and agricultural environments because of its broad spectrum insecticidal activity and effectiveness. the present study was undertaken to estimate genotoxicity of formulations of some pesticides in mice. three pesticides of diverse group studied were spinosad (45% w/v), imidacloprid (17.8%, w/v) and neem oil. animals were exposed 37, 4.5 and 50 mg kg⁻¹ b.wt. for spinosad, imidacloprid and neem oil, respectively, t ...201627097450
morphological and biochemical changes in azadirachta indica from coal combustion fly ash dumping site from a thermal power plant in delhi, india.the foliar and biochemical traits of azadirachta indica a. juss from fly ash (fa) dumping site in badarpur thermal power plant (btpp) new delhi, india was studied. three different experimental sites were selected at different distances from the thermal power plant. ambient suspended particulate matter (spm) and plant responses such as leaf pigments (chlorophyll a, chlorophyll b, and carotenoids), total chlorophyll, net photosynthetic rate, stomatal index (si), stomatal conductance (sc), intercel ...201627077968
azadirachta indica plant-assisted green synthesis of mn3o4 nanoparticles: excellent thermal catalytic performance and chemical sensing behavior.the leaf extract of azadirachta indica (neem) plant was utilized as reducing agent for the green synthesis of mn3o4 nanoparticles (nps). the crystalline analysis demonstrated the typical tetragonal hausmannite crystal structure of mn3o4, which confirmed the formation of mn3o4 nps without the existence of other oxides. green synthesized mn3o4 nps were applied for the catalytic thermal decomposition of ammonium perchlorate (ap) and as working electrode for fabricating the chemical sensor. the exce ...201627038784
therapeutics role of azadirachta indica (neem) and their active constituents in diseases prevention and treatment.neem (azadirachta indica) is a member of the meliaceae family and its role as health-promoting effect is attributed because it is rich source of antioxidant. it has been widely used in chinese, ayurvedic, and unani medicines worldwide especially in indian subcontinent in the treatment and prevention of various diseases. earlier finding confirmed that neem and its constituents play role in the scavenging of free radical generation and prevention of disease pathogenesis. the studies based on anima ...201627034694
anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development.nimbolide is one of the main components in the leaf extract of azadirachta indica (a. indica). accumulating evidence from various in vitro and in vivo studies indicates that nimbolide possesses potent anticancer activity against several types of cancer and also shows potential chemopreventive activity in animal models. the main mechanisms of action of nimbolide include anti-proliferation, induction of apoptosis, inhibition of metastasis and angiogenesis, and modulation of carcinogen-metabolizing ...201627027349
potential of neem (azadirachta indica l.) for prevention and treatment of oncologic diseases.throughout time, plants have often displayed medicinal properties that have been underscored. we often derive medicines involved in treating cancer from components in plants. azadirachta indica, commonly known as "neem", has been used to treat different ailments in many asian countries. due to its widespread beneficial uses, a. indica has often been referred to as "the wonder tree" or "nature's drug store". various parts of this plant, including, leaves, flowers, fruits, seeds, roots, bark and o ...201627019417
therapeutic and safety evaluation of combined aqueous extracts of azadirachta indica and khaya senegalensis in chickens experimentally infected with eimeria oocysts.coccidiosis is a disease of economic importance in poultry causing morbidity and mortality. reports show that azadirachta indica and khaya senegalensis have been used individually in the treatment of avian coccidiosis. we thus investigated the efficacy and safety of the combined aqueous extracts of these plants for the treatment of experimentally induced coccidiosis in broiler chickens using oocyst count, oxidative stress biomarkers, serum biochemistry, histology, and haematological parameters. ...201626989496
gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway.the lack of efficient treatment options for pancreatic cancer highlights the critical need for the development of novel and effective chemotherapeutic agents. the medicinal properties found in plants have been used to treat many different illnesses including cancers. this study focuses on the anticancer effects of gedunin, a natural compound isolated from azadirachta indica.201626988754
erratum to: apoptosis mediated leishmanicidal activity of azadirachta indica bioactive fractions is accompanied by th1 immunostimulatory potential and therapeutic cure in vivo. 201627234305
ethnobotanical uses of neem (azadirachta indica a.juss.; meliaceae) leaves in bali (indonesia) and the indian subcontinent in relation with historical background and phytochemical properties.neem (azadirachta indica; meliaceae) is widely known for its cold pressed seed oil, mainly used as insecticide, but also for cosmetic, medicinal and agricultural uses. the seed oil is widely employed in the indian subcontinent, and the leaves seem to have a lower relevance, but the ethnobotanical information of bali (indonesia) considers the utilisation of leaves for medicinal properties.201627178630
absence of cd4(+) t cell help generates corrupt cd8(+) effector t cells in sarcoma-bearing swiss mice treated with nlgp vaccine.one of the prime objectives of cancer immunology and immunotherapy is to study the issues related to rescue and/or maintenance of the optimum effector cd8(+) t cell functions by minimizing tumor-induced negative factors. in this regard the influence of host intrinsic cd4(+) helper t cells towards generation and maintenance of cd8(+) effector t cells appears controversial in different experimental settings. therefore, the present study was aimed to re-analyze the influence of cd4(+) helper t cell ...201627178306
an improved genome assembly of azadirachta indica a. juss.neem (azadirachta indica a. juss.), an evergreen tree of the meliaceae family, is known for its medicinal, cosmetic, pesticidal and insecticidal properties. we had previously sequenced and published the draft genome of a neem plant, using mainly short read sequencing data. in this report, we present an improved genome assembly generated using additional short reads from illumina and long reads from pacific biosciences smrt sequencer. we assembled short reads and error-corrected long reads using ...201627172223
of spheres and squares: can sloterdijk help us rethink the architecture of climate science?this article explores how different visions and values of science translate into different architectural shapes. i bring peter sloterdijk's 'spherology' to bear on my ethnographic fieldwork at the neem ice core base in greenland, a significant node in the global infrastructure of climate science. i argue that the visual form of the geodesic dome of the camp materializes specific values and visions of this branch of paleoclimate science, which i elaborate vis-a-vis the pragmatic claims of the sci ...201628025912
nimbolide inhibits androgen independent prostate cancer cells survival and proliferation by modulating multiple pro-survival signaling pathways.prostate cancer is the most prominent cancer in men, experiencing a relapse in disease often express high serum tnf-α levels. it has been correlated with increased cell survival and proliferation of prostate cancer cells. previous studies reported that nimbolide, a terpenoid derived from the leaves and flowers of neem tree inhibits cancer growth through selective modulation of cell signaling pathways linked to inflammation, survival, proliferation, angiogenesis and metastasis.201627889231
allergic contact dermatitis caused by argan oil, neem oil, and mimosa tenuiflora. 201627870098
azadiradione ameliorates polyglutamine expansion disease in drosophila by potentiating dna binding activity of heat shock factor 1.aggregation of proteins with the expansion of polyglutamine tracts in the brain underlies progressive genetic neurodegenerative diseases (nds) like huntington's disease and spinocerebellar ataxias (sca). an insensitive cellular proteotoxic stress response to non-native protein oligomers is common in such conditions. indeed, upregulation of heat shock factor 1 (hsf1) function and its target protein chaperone expression has shown promising results in animal models of nds. using an hsf1 sensitive c ...201627835876
neem leaf glycoprotein regulates function of tumor associated m2 macrophages in hypoxic tumor core: critical role of il-10/stat3 signaling.heterogeneous tumor microenvironment (tme), broadly divided into tumor core and peripheral sub-microenvironments, differentially polarize normal macrophages into a different form known as tumor associated m2 macrophages (m2tams) to promote tumor growth. in view of the extensive immune-editing role of nlgp, here, we have observed that nlgp is effective to convert m2tams (cd11b(+)f4/80(high)) to m1 (cd11b(+)f4/80(low)) more prominently in tumor core, along with downregulation of other m2 associate ...201627776244
green synthesis, characterization and drug delivery applications of a novel silver/carboxymethylcellulose - poly(acrylamide) hydrogel nanocomposite.biodegradable polymeric hydrogels are a unique class of macromolecular networks that can hold a large fraction of an aqueous solvent within their structures. they are particularly suitable for biomedical applications including controlled drug delivery, because of their ability to stimulate biological tissues. many hydrogel-based networks have been designed and fabricated to meet the needs of pharmaceutical and medical fields. the investigation deals with the environment friendly synthesis of bio ...201626546239
azadirachtin, a neem-derived biopesticide, impairs behavioral and hematological parameters in carp (cyprinus carpio).azadirachtin (aza) is a promisor biopesticide used in organic production and aquaculture. although this compound is apparently safe, there is evidence that it may have deleterious effects on fish. behavioral and hematological tests are grouped into a set of parameters that may predict potential toxicity of chemical compounds. here, we investigate the effects of aza, in the commercial formulation neenmax(™) , on carp (cyprinus carpio) by defining lc50 (96 h), and testing behavioral and hematologi ...201625847134
biodiesel from plant seed oils as an alternate fuel for compression ignition engines-a review.the modern scenario reveals that the world is facing energy crisis due to the dwindling sources of fossil fuels. environment protection agencies are more concerned about the atmospheric pollution due to the burning of fossil fuels. alternative fuel research is getting augmented because of the above reasons. plant seed oils (vegetable oils) are cleaner, sustainable, and renewable. so, it can be the most suitable alternative fuel for compression ignition (ci) engines. this paper reviews the availa ...201627743330
neem oil poisoning - case report of an adult with toxic encephalopathy. 201627728581
synergistic antidiabetic activity of vernonia amygdalina and azadirachta indica: biochemical effects and possible mechanism. 201627720513
a comparative evaluation on antimicrobial effect of honey, neem leaf extract and sodium hypochlorite as intracanal irrigant: an ex-vivo study.the major determinant of the success of root canal treatment depends on meticulous disinfection of the root canal using intracanal irrigants. the most commonly used root canal irrigant is sodium hypochlorite which has disadvantages of cytotoxicity and unpleasant taste. so there is a need to identify a more biocompatible root canal irrigant.201627656571
Displaying items 1 - 100 of 1460