Publications

probable phaeoacremonium parasiticum as a cause of cavitary native lung nodules after single lung transplantation.	lung nodules after lung transplantation most often represent infection or post-transplant lymphoproliferative disorder in the allograft. conversely, native lung nodules in single lung transplant recipients are more likely to be bronchogenic carcinoma. we present a patient who developed native lung cavitary nodules. although malignancy was anticipated, evaluation revealed probable phaeoacremonium parasiticum infection. phaeoacremonium parasiticum is a dematiaceous fungus first described as a caus ...	2012	23279754
onychomycosis caused by phaeoacremonium parasiticum: first case report.	a variety of non-dermatophyte moulds can cause human onychomycosis. we report an unusual case of onychomycosis caused by phaeoacremonium parasiticum, which has not been mentioned in the literature before. the diagnosis was made by a clinical-mycological correlation. the pathogen was identified by morphological characteristics and further confirmed by sequencing of the β-tubulin gene.	2011	19793203
mycetoma caused by phaeoacremonium parasiticum- a case confirmed with b-tubulin sequence analysis.		2010	20701685
brain abscess caused by phaeoacremonium parasiticum in an immunocompromised patient.	phaeoacremonium parasiticum is an environmental fungus usually associated with subcutaneous infections. we report the first documented case of central nervous system involvement with brain abscess formation in a patient with chronic granulomatous disease and review the literature on phaeoacremonium parasiticum infections.	2010	21191052
phaeohyphomycosis of subcutaneous tissue caused by phaeoacremonium parasiticum.	though phaeoacremonium parasiticum is an unusual cause of human disease, subcutaneous infection, eumycetoma, osteomyelitis, arthritis and even disseminated diseases, such as fungemia and endocarditis have been reported. here, we report a case of subcutaneous abscess on the forearm due to p. parasiticum in a 26-year-old woman. there were no obvious predisposing factors. the patient was treated with surgical debridement followed by intravenous amphotericin b and itraconazole to which she responded ...	2009	19172066
phaeoacremonium parasiticum subcutaneous infection in a kidney-transplanted patient successfully treated by surgery.	human infection caused by phaeoacremonium parasiticum is increasingly being reported. however, only a few case reports show its role as a soil-related contaminant of kidney recipients. we report here a case of a subcutaneous infection by p. parasiticum in a transplanted man. after 4 years, he reported a nonpainful nodule on his forefinger. it was surgically excised. histological examination revealed dense fibrous connective tissue showing an extensive granulomatous reaction, including the presen ...	2007	17605749
late-onset post-traumatic phaeoacremonium parasiticum endophthalmitis.	this is the first documented case of phaeoacremonium parasiticum endophthalmitis to the authors' knowledge. p. parasiticum has been described in the literature causing various skin, subcutaneous and joint infections and one case of infective endocarditis, but has never been documented as an ocular infectious agent. the most likely source of inoculation in this case was a penetrating injury caused by a stick 5 years prior to the presentation. an enucleation was avoided through treatment with intr ...	2007	17539790
subcutaneous phaeohyphomycosis caused by phaeoacremonium parasiticum in a renal transplant patient.	a 49-year-old renally transplanted man, under a five-year course of immunosuppressive therapy with prednisone and cyclosporine a, experienced a subcutaneous phaeohyphomycosis caused by phaeoacremonium parasiticum. the clinical presentation consisted of impressive, large, inflammatory and draining cystic tumors on the left foot that had been present for one year. a significant improvement was obtained with itraconazole plus intralesional injection with amphotericin b. drug interaction was observe ...	2006	17071564
phaeoacremonium parasiticum infections confirmed by beta-tubulin sequence analysis of case isolates.	phaeoacremonium parasiticum is an agent of opportunistic phaeohyphomycosis belonging to a genus encompassing numerous recently described and soon-to-be-described, difficult-to-identify human pathogens. it appears in the literature to be an uncommon etiologic agent, yet we encountered several cases in a single year. each presented problems in laboratory identification and case management. we present two cases of invasive disease with definite identification and susceptibility results. these cases ...	2006	16757622
species of phaeoacremonium associated with infections in humans and environmental reservoirs in infected woody plants.	to date, three species of phaeoacremonium have been associated with phaeohyphomycosis. these are p. parasiticum (formerly phialophora parasitica), p. inflatipes, and p. rubrigenum. numerous unknown isolates resembling phaeoacremonium spp. have in recent years been isolated from human patients as well as from woody plants that appear to be the main environmental source of these fungi. nine new phaeoacremonium species, of which six were obtained as etiologic agents of human opportunistic infection ...	2005	15814996
in vitro antifungal activities of voriconazole and reference agents as determined by nccls methods: review of the literature.	voriconazole (vfendtm) is a new triazole that currently is undergoing phase iii clinical trials. this review summarizes the published data obtained by nccls methods on the in vitro antifungal activity of voriconazole in comparison to itraconazole, amphotericin b, fluconazole, ketoconazole and flucytosine. voriconazole had fungistatic activity against most yeasts and yeastlike species (minimum inhibitory concentrations [mics] < 2 microg/ml) that was similar or superior to those of fluconazole, am ...	2001	11469757
mycetoma and phaeohyphomycosis caused by phialophora parasitica in thailand.	phaeohyphomycosis caused by phialophora parasitica is rare and it has never been documented in thailand. the first two thai cases of phaeohyphomycosis caused by p. parasitica were recognized in early 1990 at ramathibodi hospital, bangkok, thailand. both patients had underlying diseases. the fungus developed in abscesses with pigmented mycelium at the lower extremity. cultures from pus and tissue biopsies were positive for dematiaceous fungi. light microscopic features suggested p. parasitica and ...	2000	10865405
[phaeomycotic cyst caused by phaeoacremonium parasiticum].	phaeoacremonium parasiticum was identified as the causative agent of a phaeomycotic cyst seen just below the right knee of a 59-year-old healthy woman. she had no history of trauma. direct koh examination of the pus aspirated from the subcutaneous nodule revealed abundant mycelia, which were not too deeply brown in color. the nodule was surgically excised, and there was no recurrence during a half year of observation. tissue section of the excised material revealed rather a large cavity extendin ...	2000	10777819
in vitro activity of syn-2869, a novel triazole agent, against emerging and less common mold pathogens.	the in vitro activity of syn-2869 was compared with that of amphotericin b and itraconazole. mics for 100 isolates of pathogenic molds belonging to 12 species were determined by a broth microdilution adaptation of the method recommended by the national committee for clinical laboratory standards. syn-2869 and itraconazole showed comparable, good activity against the dematiaceous molds cladophialophora bantiana, cladophialophora carrionii, exophiala dermatitidis, fonsecaea pedrosoi, phialophora p ...	1999	10223947
in-vitro activity of voriconazole, itraconazole and amphotericin b against filamentous fungi.	the in-vitro fungistatic and fungicidal activities of voriconazole were compared with those of itraconazole and amphotericin b. mics for 110 isolates belonging to 11 species of filamentous fungi were determined by a broth microdilution adaptation of the method recommended by the national committee for clinical laboratory standards. minimum lethal concentrations (mlcs) of the three antifungal agents were also determined. the mic ranges of the three compounds were comparable for aspergillus flavus ...	1998	10052897
phaeohyphomycosis caused by phaeoacremonium inflatipes.	phaeoacremonium inflatipes, one of three species previously classified as strains of phialophora parasitica, was identified as the causal agent of a subcutaneous infection of the left foot of an 83-year-old woman from south carolina. the patient had a granulomatous growth over the anteromedial aspect of her left foot. it was surgically excised, which led to complete healing without complications. tissue sections of the excised mass stained with hematoxylin and eosin and gomori's methenamine silv ...	1998	9705433
phaeoacremonium parasiticum infective endocarditis following liver transplantation.		1997	9402397
atypical eumycetoma caused by phialophora parasitica successfully treated with itraconazole and flucytosine.	phialophora species are occasional pathogens causing subcutaneous and invasive disease. we report the first case of eumycetoma caused by p. parasitica in an otherwise healthy u.k. resident who visited india. she failed to respond to surgical excision and itraconazole, 400 mg daily, but responded to itraconazole, 400 mg daily, and flucytosine, 1 g three times daily, for 12 months. in vitro susceptibility testing predicted a response.	1997	9217835
subcutaneous phaeohyphomycosis in a renal transplant recipient: a case report and review of the literature.	subcutaneous phaeohyphomycosis caused by dematiaceous fungi has rarely been described in immunocompromised patients. we report a case of subcutaneous infection caused by phialophora parasitica in a renal transplant recipient. the role of early identification of the offending fungal species followed by a wide local excision in the management of such patients has been discussed.	1996	8712209
disseminated phialophora parasitica infection in humans: case report and review.	a case of recurrent systemic infection caused by phialophora parasitica occurred in an elderly woman and over a 4-year period was documented (either clinically or at autopsy) to involve two sites on the chest wall, the hip, the vertebral body, and the aorta. the infection was treated with intravenous amphotericin b and a subsequent course of terbinafine. to our knowledge, this is the first reported case of disseminated infection by p. parasitica with systemic involvement as well as of its treatm ...	1989	2682949
a case of disseminated phialophora parasitica infection.	the numbers and kinds of fungi that are known to cause human mycoses have increased greatly in the past decade. we report the first case (to our knowledge) of disseminated phialophora parasitica infection. the patient, a 92-year-old woman, had known chronic subcutaneous infection with p parasitica. the systemic nature of her disease was diagnosed at autopsy, when the organism was identified in cultures obtained from a thrombus within an abdominal aortic aneurysm and was also histologically demon ...	1989	2589949
subcutaneous phaeohyphomycotic abscess caused by phialophora parasitica in a renal allograft recipient.	a 61-year-old renal transplant recipient developed a subcutaneous leg abscess caused by phialophora parasitica. treatment with fluconazole resulted in no improvement after 18 weeks. the abscess required excision for cure. this phaeohyphomycotic infection due to p. parasitica represents the fourth case in a renal transplant recipient described in the literature.	1988	3069991
early experience with itraconazole in vitro and in patients: pharmacokinetic studies and clinical results.	the efficacy of itraconazole, a new triazole antifungal agent, was studied in vitro and assessed in patients. the mics of itraconazole for 16 strains of aspergillus fumigatus were in the same range as those of amphotericin b: less than 0.09-0.36 microgram/ml vs. less than 0.09-0.78 microgram/ml, respectively. eight adult patients with systemic fungal infections were treated orally with 100-200 mg of itraconazole two times a day. a patient with relapsing histoplasmosis (histoplasma capsulatum var ...	1987	3027850
[osteoarthritis caused by dematiaceous fungi. apropos of 3 cases].	three cases of osteoarthritis due to dematiaceous fungi are reported. the first case, a drechslera longirostrata spondylitis complicating prosthetic valve fungal endocarditis responded only to the association of amphotericin b and ketoconazole. the second patient had chronic osteoarthritis of the knee due to phialophora parasitica resistant to medical and surgical treatment after renal transplantation. these two cases are the first and the second known reports of clinical infection with these fu ...	1985	4062137
phialophora parasitica, an emerging pathogen.	monoconidial cultures derived from 12 clinical and environmental isolates of phialophora parasitica were compared with respect to morphologic and physiologic characteristics and response to antifungal agents. no yeast cells were seen in 1- and 3-week-old slide culture preparations. also, not all of the distinguishing characteristics of this species were displayed by all isolates on all media examined. although the isolates grew on sabouraud agar with chloramphenicol and cycloheximide, some inhib ...	1984	6095471
acute monoarticular arthritis due to phialophora parasitica.		1983	6829598