Publications

periungual squamous cell carcinoma induced by human papillomavirus type 59 in an immunosuppressed patient.		2009	19539867
human papillomavirus type 59 identified in a verrucous cyst of the flank.	the verrucous cyst is a non-plantar epidermoid cyst with histopathological features of human papillomavirus (hpv) infection, including papillomatosis and hypergranulosis of the cyst lining. we report the first case of a verrucous cyst demonstrating not only the histopathological and immunohistochemical features of hpv infection, but also homology with hpv type 59 on hpv genotyping. a 28-year-old male developed a palpable mass in his right flank. histological examination revealed an intradermal c ...	2006	16709488
progression from productive infection to integration and oncogenic transformation in human papillomavirus type 59-immortalized foreskin keratinocytes.	studies of changes in the virus and host cell upon progression from human papillomavirus (hpv) episomal infection to integration are critical to understanding hpv-related malignant transformation. however, there exist only a few in vitro models of both productive hpv infection and neoplastic progression on the same host background. we recently described a unique foreskin keratinocyte cell line (erin 59) that contains hpv 59 (a close relative of hpv 18). early passages of erin 59 cells (passages ...	2005	15866067
intracellular expression patterns of the human papillomavirus type 59 e1/e4 protein in cos cells, keratinocytes, and genital epithelium.	to compare and contrast the intracellular distribution pattern of the human papillomavirus type 59 (hpv 59) e1/e4 protein in cos cells, human keratinocytes, and naturally infected genital epithelium.	2004	15564743
infection with the oncogenic human papillomavirus type 59 alters protein components of the cornified cell envelope.	infection of the genital tract with human papillomaviruses (hpvs) leads to proliferative and dysplastic epithelial lesions. the mechanisms used by the virus to escape the infected keratinocyte are not well understood. infection of keratinocytes with hpv does not cause lysis, the mechanism used by many viruses to release newly formed virions. for hpv 11, a type associated with a low risk of neoplastic disease, the cornified cell envelope (cce) of infected keratinocytes is thin and fragile, and tr ...	2003	12726726
human papillomavirus type 59 immortalized keratinocytes express late viral proteins and infectious virus after calcium stimulation.	human papillomavirus type 59 (hpv 59) is an oncogenic type related to hpv 18. hpv 59 was recently propagated in the athymic mouse xenograft system. a continuous keratinocyte cell line infected with hpv 59 was created from a foreskin xenograft grown in an athymic mouse. cells were cultured beyond passage 50. the cells were highly pleomorphic, containing numerous abnormally shaped nuclei and mitotic figures. hpv 59 sequences were detected in the cells by dna in situ hybridization in a diffuse nucl ...	2003	14554084
propagation of human papillomavirus type 59 in the athymic mouse xenograft system.	studies of human papillomavirus (hpv) infection are hampered by the lack of an adequate culture system. the athymic mouse xenograft system permits propagation of hpv, but only a few hpv types have been grown in this manner. to produce an oncogenic type for studies of hpv pathogenesis, a condylomata acuminata lesion from an immunosuppressed patient was used to prepare an infectious extract. the patient's lesion was shown by pcr analysis to contain abundant hpv 59 (an oncogenic type) and a lesser ...	2000	10971130
identification of cis-regulatory elements in the upstream regulatory region of human papillomavirus type 59.	human papillomavirus type 59 (hpv-59) was cloned from a vulvar intraepithelial neoplasia and the complete nucleotide sequence was determined. this virus is closely related to hpv-18 and -39 (60% homology in nucleotide sequence) and is grouped with the genital hpv types. in the present paper, we demonstrate that the hpv-59 e2 transactivator represses its e6 promoter-mediated transcription. we have also analyzed cis-regulatory elements in the upstream regulatory region (urr) of hpv-59 using chlora ...	1997	9085547
transforming activities of human papillomavirus type 59 e5, e6 and e7 open reading frames in mouse c127 cells.	the dna sequence from a human papillomavirus type 59 (hpv 59) has been recently determined. the hpv 59 genome consists of 7896 nucleotides (nt). a comparative analysis of this sequence with the sequences of other hpvs revealed the closest homology to hpv 18 (71%). to test the transforming activities of hpv 59 dna and its gene products, several plasmids expressing hpv 59 open reading frames (orf) were constructed. the e5, e6, and e7 orfs of hpv 59 were inserted into prc/cmv vector containing a pr ...	1996	8873413
nucleotide sequence and phylogenetic classification of human papillomavirus type 59.	the complete nucleotide sequence of the hpv 59 dna genome, isolated from a vulvar intraepithelial neoplasia, was determined. it consists of 7896 nucleotides. a comparative analysis of this sequence with the sequences of other hpv types revealed the closest homology to hpv 18 (71%), hpv 45 (70%), and hpv 39 (69%). phylogenetic analysis of the complete l1 orfs of hpv 59 and other papillomaviruses exclusively groups all hpvs which have been detected in mucosal lesions into one major branch. this ma ...	1994	8030272
frequency of sexually transmitted diseases among university students.	to estimate the incidence rate of sexually transmitted diseases (stds) among university students and evaluate the associated sociodemographic factors.	1993	8388772