Publications

TitleAbstractYear(sorted descending)
Filter
PMID
Filter
Enzymatic activity of Microsporum canis and Trichophyton mentagrophytes from breeding rabbits with and without skin lesions.Microsporum canis and Trichophyton mentagrophytes are zoophilic dermatophytes which can cause skin infections in animals and humans. The clinical expression of this infection strongly varies depending on host, fungal species as well as enzyme production. No comparative studies are available on the enzymatic activities of M. canis and T. mentagrophytes isolated from breeding rabbits. Thus, the aim of this work was to assess the capability of M. canis and T. mentagrophytes isolated from rabbits bo ...201222175244
multilocus differentiation of the related dermatophytes microsporum canis, microsporum ferrugineum and microsporum audouinii.microsporum ferrugineum, an uncommon causative agent of dermatophytosis, has restricted endemicity. iranian strains suspected to be m. ferrugineum from two patients with tinea were analysed using the rdna internal transcribed spacer (its) region and the partial β-tubulin (bt2) and translation elongation factor 1-α (tef1) genes. strains were compared to reference strains to differentiate m. ferrugineum from its relatives microsporum canis and microsporum audouinii. inter-species differences for t ...201221903828
two pediatric cases of microsporum persicolor infection. 201222250631
antifungal property of quaternized chitosan and its derivatives.five water-soluble chitosan derivatives were carried out by quaternizing either iodomethane or n-(3-chloro-2-hydroxypropyl) trimethylammonium chloride (quat188) as a quaternizing agent under basic condition. the degree of quaternization (dq) ranged between 28±2% and 90±2%. the antifungal activity was evaluated by using disc diffusion method, minimum inhibitory concentration (mic) and minimum fungicidal concentration (mfc) methods against trichophyton rubrum (t. rubrum), trichophyton mentagrophyt ...201222100980
preparation and evaluation of dermal delivery system of griseofulvin containing vitamin e-tpgs as penetration enhancer.griseofulvin, an antifungal agent, is a bcs class ii drug slowly, erratically, and incompletely absorbed from the gastrointestinal tract in humans. the clinical failure of the conventional oral therapy of griseofulvin is most likely attributed to its poor solubility and appreciable inter- and intra-subject variation in bioavailability from different commercial products. moreover, the conventional oral therapy is associated with numerous adverse effects and interactions with other drugs. the purp ...201122130790
Difference in keratinase activity of dermatophytes at different environmental conditions is an attribute of adaptation to parasitism.Dermatophytes are a group of morphologically and physiologically related moulds, which cause well-defined infection called dermatophytosis. The enzymatic ability of fungi to decompose keratin has long been interpreted as a key innovation in the evolution of animal dermatology. In the present study, keratinase activity profile among Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis and Microsporum gypseum isolated on keratin substrates such as human hair, human nail and chicken ...201122032519
[fungi, pets and their owners].some parasitic or pathogen fungi for pet skin are possibly transmitted to humans in whom they are responsible for superficial mycozoonoses. cats, dogs and some small rodents are commonly involved. the lesions correspond to glabrous skin dermatophytoses and to microsporic tinea of the scalp. these disorders represent the vast majority of the prevalent mycozoonoses in wallonia. microsporum canis and trichophyton mentagrophytes are the two fungi that are commonly involved.201122216732
chemical and biological diversity in fourteen selections of four ocimum species.biomass, essential oil yield, essential oil composition diversity, and antibacterial and antifungal activities of 14 selections of 4 ocimum species [ocimum basilicum l. (selections: t1-t10), o. gratissimum l. (selections: t11-t12), o. tenuiflorum l.f., syn. o. sanctum l. (selection: t13) and o. kilimandscharicum baker ex. guerke (selection: t14)] were investigated. o. basilicum selections t9 (methyl chavicol: 87.0%) and t10 {(z)- and (e)-methyl cinnamate: 69.1%} produced higher biomass (67.8 and ...201122224293
mechanisms of skin adherence and invasion by dermatophytes.dermatophytes are keratinophilic fungi that can be pathogenic for humans and animals by infecting the stratum corneum, nails, claws or hair. the first infection step consists of adherence of arthroconidia to the stratum corneum. the mechanisms and the kinetics of adherence have been investigated using different in vitro and ex vivo experimental models, most notably showing the role of a secreted serine protease from microsporum canis in fungal adherence to feline corneocytes. after germination o ...201121831104
dermatophytosis due to microsporum persicolor: a retrospective study of 16 cases.a retrospective study of 16 cases of dermatophytosis due to microsporum persicolor in dogs is reported. hunting dogs were overrepresented (12/16). skin lesions were observed on the face in all cases, but also on other locations (limbs, neck). the lesions included alopecia (15/16), erythema (13/16), scales (14/16), and crusts (13/16). histopathology was performed in 10 cases and showed folliculitis and a lichenoid interface dermatitis. fungal culture was positive in all cases and clinical resolut ...201121731090
microsporum mirabile and its teleomorph arthroderma mirabile, a new dermatophyte species in the m. cookei clade.a novel dermatophyte species is described in the microsporum cookei clade. it differs significantly from known taxa in the two molecular markers analyzed, i.e., its and partial +¦-tubulin (bt2). morphologically the species was characterized by smooth- or only slightly rough-walled conidia, but isolates rapidly became pleomorphic with sparse, smooth- and thick-walled macroconidia in addition to microconidia. a teleomorph was found after mating.201121838616
Substituted 2-aminothiophenes: antifungal activities and effect on Microsporum gypseum protein profile.The increasing recognition and importance of fungal infections, the difficulties encountered in their treatment and the increase in resistance to antifungal agents have stimulated the search for therapeutic alternatives. The objective of this study was to evaluate the antifungal activities of three substituted 2-aminothiophenes (1, 2 and 3) against some fungal species. The synthesis of substituted 2-aminothiophenes was carried out through the most versatile synthetic method developed by Gewald e ...201121831103
ganoderma lucidum: a source for novel bioactive lectin.ganoderma lucidum is known for its high medicinal value, clinically used in treatment for various diseases. we have selected this mushroom for isolation of novel bioactive lectin. the isolation procedure comprised of ion-exchange chromatography on deae- cellulose and affinity chromatography on affi-gel blue gel. purified lectin was monomer with a molecular mass of 15 kda, determined by sds-page, gel filtration, maldi-tof. it showed hemagglutinating activity against both human and animal erythroc ...201121728991
outbreak of tinea capitis and corporis in a primary school in antananarivo, madagascar.tinea capitis is common among schoolchildren in developing countries but underreported in madagascar. we report the occurrence of an outbreak of gray patch tinea capitis due to microsporum langeronii in a public primary school of antananarivo, the capital city of madagascar.201121997943
Zoonoses of procyonids and nondomestic felids.There are several important zoonotic diseases which can be acquired from procyonids, and nondomestic felids. Baylisascaris procyonis, the raccoon roundworm, is a common parasite of raccoons and can cause visceral, ocular, or neural larval migrans in people. Neural larval migrans can cause severe signs in individuals. Dermatophytosis and enteric pathogens are the most important zoonotic agents found in nondomestic felids. Microsporum canis infections can be spread from nondomestic felids to owner ...201121872788
strains differentiation of microsporum canis by rapd analysis using (gaca)4 and (aca)5 primers.molecular analysis of dermatophytes (based on pcr fingerprinting) revealed high clonal differentiation between the genus and species. microsporum canis (zoophilic dermatophyte, belonging to genus microsporum), responsible for most cases of tinea capitis in children, tinea corporis in adults and dermatophytoses in cats, is very unique in comparison with other dermatophytes. results of most molecular studies show that there is no clonal differentiation within m. canis as distinct from other specie ...201121905632
anthraquinone profile, antioxidant and antimicrobial properties of bark extracts of rhamnus catharticus and r. orbiculatus.the anthraquinone profile, antioxidant and antimicrobial activities as well as the total phenol and total flavonoid contents were determined in methanol extracts of the barks of rhamnus catharticus l. and r. orbiculatus bornm. the most abundant anthraquinone derivatives in r. catharticus were physcion (67.8%) and emodin (26.2%), while r. orbiculatus contained mostly physcion (81.3%) and chrysophanol (14.6%). r. catharticus displayed better activity in the beta-carotene-linoleic acid assay, as we ...201121941897
The dog mite, Demodex canis: prevalence, fungal co-infection, reactions to light, and hair follicle apoptosis.Infection rate, reaction to light, and hair follicle apoptosis are examined in the dogmite, Demodex canis Leydig (Prostigmata: Demodicidae), in dogs from the northern area of Taiwan. An analysis of relevant samples revealed 7.2% (73/1013) prevalence of D. canis infection. Infection during the investigation peaked each winter, with an average prevalence of 12.5% (32/255). The infection rates significantly varied in accordance with month, sex, age, and breed (p < 0.05). Most of the lesions were di ...201121867442
isolation of the volatile oil from satureja thymbra by supercritical carbon dioxide extraction: chemical composition and biological activity.satureja thymbra l. is well known in italy by the popular name of "santoreggia sarda". it grows only in sardinia and nowadays it is restricted to the slope of the colle san michele in cagliari. the composition of the aromatic extracts obtained by supercritical co2 and by hydrodistillation and their antifungal activity is reported. the collected extracts were analyzed by gc-fid and gc-ms methods. no significant differences were observed in the composition of the volatile extracts depending on the ...201122164799
microsporum canis tinea capitis in a centenarian patient. 201121860180
mating genes of the trichophyton mentagrophytes complex.the mating type (-)-specific gene of the alpha-box and the mating type (+)-specific gene of the high-mobility group (hmg) dna-binding domain were confirmed in zoophilic dematophytes of arthroderma simii and a. vanbreuseghemii. the sequence of the alpha-box gene was 1,375 bp, containing 2 exons (from 172 to 463 bp and from 513 to 1,375 bp) in the a. simii (-) mating type strain and 1,380 bp, containing 2 exons (from 177 to 468 bp and from 518 to 1,380 bp) in the a. vanbreuseghemii (-) mating type ...201122057847
brittle tail syndrome is an emerging infection in horses caused by a keratinolytic fungus equicapillimyces hongkongensis gen. nov., sp. nov.the newly described brittle tail syndrome causes weakening and breakage of the tail hair of horses. extensive mycological and molecular studies showed that a novel fungus equicapillimyces hongkongensis gen. nov., sp. nov. is the most likely cause of this syndrome. it is a septate branching hyaline mould which grows optimally at 30°c, requires nicotinic acid but is inhibited by cycloheximide, and specifically infects horse hair. hyphae fill the core of infected hair shafts with short-necked struc ...201122014601
Interkingdom Gene Transfer of a Hybrid NPS/PKS from Bacteria to Filamentous Ascomycota.Nonribosomal peptides (NRPs) and polyketides (PKs) are ecologically important secondary metabolites produced by bacteria and fungi using multidomain enzymes called nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs), respectively. Previous phylogenetic analyses of fungal NRPSs and PKSs have suggested that a few of these genes were acquired by fungi via horizontal gene transfer (HGT) from bacteria, including a hybrid NPS/PKS found in Cochliobolus heterostrophus (Dothideomycet ...201122140558
Chemical composition and biological activity of the volatile extracts of Achillea millefolium.In this study, flowering aerial parts of wild Achillea millefolium growing on the Mediterranean coast (Sardinia Island, Italy) and on the Atlantic coast (Portugal- Serra de Montemuro) were used as a matrix for supercritical extraction of volatile oil with CO2 (SFE). The collected extracts were analyzed by GC-FID and GC-MS methods and their composition were compared with that of the essential oil isolated by hydrodistillation. A strong chemical variability in essential oils depending on the origi ...201122164800
[superficial mycoses in the city of valparaiso, chile: period 2007-2009].superficial mycoses are infections of the keratinous tissue caused by dermatophytes, yeasts and environmental fungi.201122051613
[mycological and epidemiological aspects of tinea capitis in the sousse region of tunisia].tinea capitis continues to be considered a public health problem in tunisia. the purpose of our study was to investigate trends in the incidence and the mycological and epidemiological aspects of tinea capitis in the sousse region (central tunisia).201121893228
Broad spectrum antidermatophytic drug for the control of tinea infection in human beings.During antifungal evaluation of various plant extracts, free and bound flavonoids of Piper betle were found to be most effective as an antidermatophytic against human pathogenic dermatophytes Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum gypseum and Candida albicans. Dermatophytic fungi cause both superficial and internal mycoses. These mycoses, although normally not lethal, are unpleasant and difficult to cure and cause considerable financial losses. Earlier workers prove that a ...201121929713
tinea faciei due to microsporum canis in children: a survey of 46 cases in the district of cagliari (italy).dermatophytoses are frequent in children, but involvement of the facial skin has peculiar aspects that should be considered a separate entity: tinea faciei. microsporum canis infection in tinea faciei has not been widely documented. to review cases of tinea faciei due to m. canis in children diagnosed at the dermatology clinic, university of cagliari. between 1990 and 2009, all children with dermatophyte infections of the facial skin were recruited for the study after parental consent. diagnosis ...201122011084
identification of novel secreted proteases during extracellular proteolysis by dermatophytes at acidic ph.the dermatophytes are a group of closely related fungi which are responsible for the great majority of superficial mycoses in humans and animals. among various potential virulence factors, their secreted proteolytic activity attracts a lot of attention. most dermatophyte-secreted proteases which have so far been isolated in vitro are neutral or alkaline enzymes. however, inspection of the recently decoded dermatophyte genomes revealed many other hypothetical secreted proteases, in particular aci ...201121919205
analysis of the differentially expressed genes in microsporum canis in inducing smooth skin and scalp tissue conditions.microsporum canis is a common zoophilic dermatophyte, which causes a range of infections. to explore the pathogenic mechanism of tinea capitis, we used the suppression subtractive hybridization (ssh) technique to investigate the differences in gene expression between different cultures of microsporum canis incubated on three different types of mineral media containing child glabrous skin, child scalp tissue and adult scalp tissue. using dot-blot hybridization and real-time pcr technique, we succ ...201121883399
Antifungal activity and chemical composition of essential oils from Smyrnium olusatrum L. (Apiaceae) from Italy and Portugal.The essential oils and supercritical CO(2) extracts of wild Smyrnium olusatrum L. growing in Sardinia (Italy) and in Portugal were investigated. For the study, oils were isolated from total plant aerial part (umbels containing seeds). The content of ß-phellandrene (67.3% vs. 42.7%) and a-pinene (31.9% vs. 1.2%), respectively, the main components of Portuguese and Italian essential oils, declined during the maturation stage of the umbels. Contrarily, some other important components, particularly ...201121902563
Assessment of antimicrobial, insecticidal and genotoxic effects of Melia azedarach L. (chinaberry) naturalized in Anatolia.In this study, antibacterial, antifungal, insecticidal and genotoxic activities of the fruit and leaf extracts of Melia azedarach of Turkish origin were evaluated for the first time. The antimicrobial activity was assessed against Gram (+) and ( - ) bacteria, four Candida species and three dermatophytic fungus (Trichophyton rubrum, Epidermophyton floccosum and Microsporum gypseum). The insecticidal activity of the methanolic fruit extract was performed against the larvae of Aedes aegpyti, Culex ...201122149768
Decreasing Prevalence of Microsporum canis Infection in Korea: Through Analysis of 944 Cases (1993-2009) and Review of Our Previous Data (1975-1992).Since 1957, Microsporum (M.) canis has been one of the common causative agents of dermatophytosis in Korea. We analyzed 944 patients infected with M. canis who attended outpatient clinic over a 17-year period (1993-2009). M. canis infections were diagnosed by mycological examinations, including direct microscopic examinations with 15% KOH and cultures on potato dextrose agar complemented with 0.5% chloramphenicol. Mycological examinations confirmed 164,903 cases of dermatophytosis, 944 (0.6%) of ...201122187358
design, synthesis and antifungal activity of some new imidazole and triazole derivatives.triazole and imidazole are incorporated into the structures of many antifungal compounds. in this study a novel series of 1,2,4-triazole, imidazole, benzoimidazole, and benzotriazole derivatives was designed as inhibitors of cytochrome p450 14α-demethylase (14dm). these structures were docked into the active site of mt-cyp51, using autodock program. sixteen compounds with the best binding energy were synthesized. the chemical structures of the new compounds were confirmed by elemental and spectr ...201121984016
Identification of rare macroconidia-producing dermatophytic fungi by real-time PCR.To understand the pathogenicity and clinical significance of dermatophytes (also known as ringworms), the correct identification of these molds is essential. However, in routine practice they are notoriously difficult to classify and identify. The morphology of macroconidia, which are abundantly produced under suitable in vitro conditions, have provided useful criteria for the identification of many of the dermatophytes. However, several of them, including Microsporum audouinii, M. ferrugineum, ...201121954954
[tinea capitis].tinea capitis is a fungal infection of the scalp. this disease is primarily caused by dermatophytes that invade the hair shaft. the clinical appearance is typically single or multiple lesions of hair loss that may be accompanied by inflammation, scaling, and pustules. the incidence in girls and females overall has recently increased, although many boys were previously affected. trichophyton or microsporum species of dermatophytes transmitted by humans or animals are commonly associated with this ...201121441707
clinico-epidemiological and mycological aspects of tinea incognito in iran: a 16-year study.tinea incognito is a dermatophytic infection in which topical or systemic steroids have modified the clinical appearance of the mycosis and mimicking other skin diseases.201121441710
[clinical, diagnostic and therapeutic aspects of dermatophytosis].dermatophytes are a group of closely related fungi that have keratinase and can therefore cause infections in keratinised human and animal tissues (skin, hair and nails), leading to a disease known as dermatophytosis. this group is composed by the genera epidermophyton, trichophyton and microsporum, forming an approximated total of 40 species. depending on the source of the keratin used, dermatophytes can be divided in geophilic (soil), zoophilic (animals) and anthropophilic (human), with soil, ...201121458709
two unusual pediatric cases of fungal infections in farming families.it is not known whether farming families have more cases of uncommon fungal infections than the general population because of their interdependence on farming environments, including farm animals and other pets. the authors describe here two cases of fungal infections with interesting epidemiology that suggest associations that have been insufficiently described and explored in the literature. the first is a case of otomycosis in a 17-year-old female and is suspected to be linked to hay baling. ...201121462027
tinea incognito caused by microsporum gypseum in a patient with advanced hiv infection: a case report.the prevalence and the clinical relevance of dermatophytoses in hiv-infected patients are poorly documented, particularly for those caused by tinea incognito. here, we report a case of widespread facial tinea incognito occurring in an italian patient with advanced hiv infection, showing both skin and brain lesions. second-line treatment with liposomal amphotericin b and cotrimoxazole, administered after a microbiological characterization of the skin scrapings, led to complete clearance of all le ...201121487462
gmi, an immunomodulatory protein from ganoderma microsporum, induces autophagy in non-small cell lung cancer cells.autophagy is a self-digestive process that degrades the cytoplasmic constituents. immunomodulatory protein, one major bioactive component of ganoderma, has antitumor activity. in this study, recombinant fungal immunomodulatory protein, gmi, was cloned from ganoderma microsporum and purified. we demonstrated that gmi induces lung cancer cell death by activating autophagy, but does not induce apoptotic cell death. on western blot, gmi increased lc3 conversion and decreased p53 expression in a time ...201121490426
prevalence of dermatophytosis among primary school children in oke-oyi community of kwara state.background: dermatophytic infections have been known to impact negatively on health and well-being of children. this study was undertaken to determine the prevalence, clinical types as well as the etiologic organisms of dermatophyte infection among primary school children aged 5-16 years in oke-oyi community in kwara state. materials and methods: a 4-months descriptive cross-sectional survey was carried out among 602 children aged 5-16 years in oke-oyi community, in kwara state. results: the pre ...201121493987
neonatal dermatophytosis: report of a case and review of the literature.tinea capitis is a common fungal infection in children but rare among neonates. we present a case of a 3-week-old infant with multiple scalp lesions for 1 week. a diagnosis of tinea capitis due to microsporum canis was made based on clinical morphology, wood's lamp, and biopsy with a positive pas stain. she was effectively treated with oral griseofulvin and ketoconazole shampoo.201121504448
mycetoma of the scalp due to microsporum canis: hystopathologic, mycologic, and immunogenetic features in a 6-year-old girl.dermatophytic mycetoma is an extremely rare subcutaneous mycosis. here, we report the case of a 6-year-old girl with clinical, histologic, and mycologic findings consistent with a mycetoma of the scalp caused by microsporum canis. to our knowledge, this is the first report showing the immunologic and immunogenetic features of a patient with a recalcitrant dermatophytic mycetoma.201121513850
synthesis, characterization and biological studies of sulfonamide schiff's bases and some of their metal derivatives.a new series of schiff base ligands derived from sulfonamide and their metal(ii) complexes [cobalt(ii), copper(ii), nickel(ii) and zinc(ii)] have been synthesized and characterized. the nature of bonding and structure of all the synthesized compounds has been explored by physical, analytical and spectral data of the ligands and their metal(ii) complexes. the authors suggest that all the prepared complexes possess an octahedral geometry. the ligands and metal(ii) complexes have been screened for ...201121534864
a new compound, jolynamine, from marine brown alga jolyna laminarioides.a new compound, jolynamine (1), was isolated from the marine brown alga jolyna laminarioides collected from the coast of karachi, pakistan. in addition, four known compounds, namely saringosterol (2), loliolide (3), methyl-4-hydroxybenzoate (4) and propyl-4-hydroxybenzoate (5), were isolated for the first time from the marine brown alga iyengaria stellata, and two known compounds, namely 3,4,5-trimethylaniline (6) and harmine (7), were isolated for the first time from the marine brown alga melan ...201121547840
essential oils of medicinal plants from the central andes of argentina: chemical composition, and antifungal, antibacterial, and insect-repellent activities.the antifungal, antibacterial, and insect-repellent activities of the essential oils (eos) of acantholippia seriphioides, artemisia mendozana, gymnophyton polycephalum, satureja parvifolia, tagetes mendocina, and lippia integrifolia, collected in the central andes area, province of san juan, argentina, were investigated. the dermatophytes microsporum gypseum, trichophyton mentagrophytes, and t. rubrum were inhibited by the eos of g. polycephalum, l. integrifolia, and s. parvifolia, with minimum ...201121560241
melanogenesis in dermatophyte species in vitro and during infection.dermatophytes are keratinophilic fungi that are the most common cause of fungal skin infections worldwide. melanin has been isolated from several important human fungal pathogens and the polymeric pigment is now recognized as an important virulence determinant. this study investigated whether dermatophytes, including trichophyton rubrum, t. mentagrophytes, epidermophyton floccosum, and microsporum gypseum, produce melanin or melanin-like compounds in vitro and during infection. digestion of the ...201121565930
terbinafine pharmacokinetics after single dose oral administration in the dog.terbinafine is an allylamine antifungal prescribed for the treatment of mycoses in humans. it is increasingly being used in veterinary patients. the purpose of this study was to evaluate the pharmacokinetic properties of terbinafine in dogs after a single oral dose. ten healthy adult dogs were included in the study. a single dose of terbinafine (30-35 mg/kg) was administered orally, and blood samples were periodically collected over a 24 h period during which dogs were monitored for adverse effe ...201121599768
argentinean andean propolis associated with the medicinal plant larrea nitida cav. (zygophyllaceae). hplc-ms and gc-ms characterization and antifungal activity.the chemical profile and botanical origin of andean argentinian propolis were studied by hplc-esi-ms/ms and gc-ms techniques as well as the antifungal activity according to clsi protocols. dermatophytes and yeasts tested were strongly inhibited by propolis extracts (mics between 31.25 and 125μg/ml). the main antifungal compounds were: 3'methyl-nordihydroguaiaretic acid (mndga) 1, nordihydroguaiaretic acid (ndga) 2 and a ndga derivative 3, showing strong activity against trichophyton mentagrophyt ...201121600954
standardization of hyphal growth inhibition rate as a means of evaluating microsporum spp. in vitro susceptibility to terbinafine, griseofulvin, and ciclopiroxolamine.reference methods for antifungal susceptibility tests recommend the use of conidia as inoculum. however, some isolates produce few conidia, while the invasive form of filamentous fungi in general is hyphae making susceptibility tests infeaseble. these facts suggest that other than conidia broth dilution method is required for susceptibility tests. the aim of this study was to clarify if the hyphal growth inhibition rate could be used as a method of determining the antifungal susceptibility of ge ...201121611866
cluster analysis of microsporum canis isolated from a patient with tinea corporis and an infected cat based on the dna sequences of nuclear ribosomal internal transcribed spacer 1. 201121615535
antidermatophytic activity of pyrazolo[3,4-c]isothiazoles: a preliminary approach on 4-chlorophenyl derivative for evaluation of mutagenic and clastogenic effects on bacteria and human chromosomes in vitro.the antifungal activity of eight pyrazolo[3,4-c]isothiazole derivatives was evaluated on five dermatophytes: three were of an anthropophilic species (i.e., epidermophyton floccosum, trichophyton rubrum, and trichophyton tonsurans) and two were of a geophilic species (i.e., microsporum gypseum and nannizzia cajetani). the new compounds proved to be unlikely effective in inhibiting the growth of the different strains. in general, the fungi parasitic on man were more sensitive than the geophilic sp ...201121649488
modiolide and pyrone derivatives from the sea fan-derived fungus curvularia sp. psu-f22.investigation of secondary metabolites from the sea fan-derived fungus curvularia sp. psu-f22 resulted in isolation of three new metabolites, curvulapyrone (1), curvulalide (2) and curvulalic acid (3) together with six known compounds, modiolides a (4) and b (5), pyrenolide a (6), stagonolide e (7), mycoepoxydiene (8), and deacetylmycoepoxydiene (9). their antimicrobial activity against staphylococcus aureus atcc 25923, methicillin-resistant s. aureus and microsporum gypseum sh-mu-4 were examine ...201121656354
analysis of 25 cases of microsporum canis infection encountered at a dermatology clinic in kumamoto during a recent 3-year period.twenty-five cases of dermatophytoses caused by microsporum canis were encountered during a 3-year period (january 2008-december 2010). their diagnosis was based on detection of fungal elements by direct microscopy and identification of m. canis by fungal culture. there were 17 women and 8 men ; they ranged in age from 4 to 85 years (mean, 34.6). the affected site was the head (n=5), face (n=8), neck (n=5), arm (n=8), leg (n=5), and trunk (n=5) ; exposed sites were those most often affected. a lo ...201121788725
[scalp ringworm tinea capitis in tunisian infants.]objective: the aim of the study was to specify the epidemiological, clinical, and mycological particularities of tinea capitis in infants. design: we retrospectively collected data from the files of 245 infants presenting with tinea capitis, followed in the hedi-chaker hospital dermatology department and in two mycology laboratories of the sfax hospital, between january 1995 and december 2006. we collected the epidemiological, clinical, and mycological data for each patient. results: we included ...201121764534
molecular identification and phylogenesis of dermatophytes isolated from rabbit farms and rabbit farm workers.little information is available on the molecular epidemiology of dermatophytoses in rabbit farms and farm workers. a total of 117 isolates belonging to the trichophyton mentagrophytes complex and 21 isolates of microsporum canis were collected from rabbits with or without skin lesions, air samples of farms known to harbour these pathogens, and from farm workers with skin lesions, and molecularly characterized. sequencing of amplicons from the t. mentagrophytes complex and m. canis isolates revea ...201121840652
microsporum praecox: molecular identification of a new case and review of the literature.we report a rare case of dermatophytosis due to microsporum praecox in a 28-year-old female horse rider. the skin lesion was located on the right external malleolus. microscopic examination of skin scrapings revealed a dermatophyte which was also isolated in culture. the identification of m. praecox was confirmed by molecular biology (sequence analysis of pcr products amplified from internal transcribed spacer regions with universal primers). combined antifungal therapy with oral terbinafine and ...201120658321
a case of kerion celsi caused by microsporum gypseum in a boy following dermatoplasty for a scalp wound from a road accident.we report a rare case of kerion celsi of the scalp caused by microsporum gypseum in a boy 1 month after he received dermatoplasty for a scalp injury from a road accident. species identification was performed by observation of morphologic and biochemical characteristics and sequencing of the internal transcribed spacers (its) 1 and 2. treatment with oral terbinafine and topical naftifine-ketoconazole cream after washing the hair with ketoconazole shampoo was effective.201120662636
a 30-year survey of paediatric tinea capitis in southern spain.tinea capitis (tc) is the most common mycological infection in childhood. the epidemiology of tc varies depending on the geographical area and the time of study, and although it is an important public health problem in our area, only a few long-term studies have focused on children.201120553362
changes of dermatophytoses in southwestern greece: an 18-year survey.the isolation and distribution rate of dermatophytes as causative agents of superficial mycoses of skin, hair, and nails during an 18-year period (1991-2008) at a university hospital are presented. a comparative analysis of epidemiological differences within the first (1991-1999) and the second 9-year period (2000-2008) was performed. skin scrapings, nail, and hair specimens were examined by a direct microscopic examination and culture. identification of dermatophyte species was based on macrosc ...201121331751
meta-analysis of randomized, controlled trials comparing griseofulvin and terbinafine in the treatment of tinea capitis.griseofulvin has been the standard treatment for tinea capitis but newer antifungal agents, particularly terbinafine, are increasingly being used because of their shorter duration of treatment and more consistent absorption rates.201121334096
synthesis and in vitro microbiological evaluation of novel diethyl 6,6'-(1,4-phenylene)bis(4-aryl-2-oxo-cyclohex-3-enecarboxylates).novel bis cyclohexenone ester derivatives 14-19 were synthesized and characterized by their spectral data. in vitro microbiological evaluations were carried out for all the novel compounds 14-19 against clinically isolated bacterial and fungal strains. compounds 15, 16, 18 against staphylococcus aureus, 14, 15 against ß-haemolytic streptococcus, 15, 19 against micrococcus luteus, 17, 18 against salmonella typhii, 14, 17 against shigella flexneri, 15 against escherichia coli, 16 against pseudomon ...201121417963
corkscrew hair: a new dermoscopic sign for diagnosis of tinea capitis in black children. 201121422348
distribution of dermatophytes and other related fungi in jaipur city, with particular reference to soil ph.screening of 217 soil samples of different habitats, such as pg study centre, garden, farmhouse, nursery, roadside, hostel, animal habitat, bird habitat, marriage garden, temple, vegetable market and house dust, was carried out for the presence of dermatophytes and related fungi in relation to soil ph. a total of 461 isolates belonging to 26 genera and 34 species were recorded. soil ph values vary from 3 to 10.5. trichophyton verrucosum, microsporum audouinii and m. canis were isolated for the f ...201119638000
tinea capitis mimicking folliculitis decalvans.we report on an adult patient with tinea capitis caused by microsporum canis, who presented with diffuse alopecia and follicular pustules, mimicking folliculitis decalvans. examination of the scalp showed severe alopecia with prominent involvement of the frontal and vertex scalp: the skin was markedly erythematous with pustules and brownish crusts. videodermoscopy revealed visible follicular ostia, numerous pustular lesions and several comma hairs. fluconazole 150 mg a week for 8 weeks associate ...201119638002
tinea capitis caused by trichophyton soudanense and microsporum audouinii in an adult: a case report.this report presents a rare case of tinea capitis caused by trichophyton soudanense and microsporum audouinii in a 31-year-old woman from senegal. the patient showed atrophic skin lesions causing cicatricial alopecia, scarring being caused by two aetiological agents uncommon in spain.201119712077
direct detection of five common dermatophyte species in clinical samples using a rapid and sensitive 24-h pcr-elisa technique open to protocol transfer.identification of dermatophytes is usually based on morphological characteristics determined by time-consuming microscopic and cultural examinations. an effective pcr-elisa method has been developed for rapid detection of dermatophyte species directly from clinical specimens within 24 h. isolated genomic dna of skin scrapings and nail samples from patients with suspected dermatophyte infections is amplified with species-specific digoxigenin-labelled primers targeting the topoisomerase ii gene. t ...201119793206
outbreak of ringworm in a traditional iberian pig farm in spain.an outbreak of dermatophytosis caused by microsporum nanum in a traditional iberian extensive farm is described. the morbidity was 100% among lactating sows; however, suckling and weaning pigs, as well as boars never developed the lesions seen in the sows. the clinical aspects of porcine ringworm caused by this fungus are discussed and the ecology of the organism is reviewed.201119821905
prevalence of tinea capitis in southeastern austria between 1985 and 2008: up-to-date picture of the current situation.tinea capitis is the most common dermatophyte infection in childhood, but may rarely occur in adults and the elderly. causative agents vary within different geographical areas as well as during decades. the aim of this study was to evaluate the prevalence and causative agents of tinea capitis in southeastern austria. retrospective analysis of 714 patients diagnosed with tinea capitis seen at the outpatient department of dermatology/medical university of graz during the time period 1985-2008 was ...201119863725
use of western blot to study microsporum canis antigenic proteins in canine dermatophytosis.western blotting was used to describe the microsporum canis proteins with antigenic activity in dogs with dermatophytosis. electrophoretic separation of whole fungal strain extract cultured from a cat was performed under denaturing conditions. the proteins were blotted onto nitrocellulose and probed with sera collected from 22 dogs with dermatophytosis (18 m. canis, 3 m. gypseum, 1 trichophyton mentagrophytes; group a), 20 dogs with skin diseases other than dermatophytosis, and 22 dogs with no c ...201119912544
a 5-year survey of dermatomycoses in southwest poland, years 2003-2007.the study was performed to analyse the spectrum of dermatomycoses in southwest poland during the period 2003-2007. a total of 10,486 patients were investigated for fungal skin infections by means of native specimen and cultivating procedures. skin scrapings, plucked hairs and nail clippings were examined and identified by direct microscopy and culture. from 2468 patients, 2753 fungi were identified including dermatophytes, yeast and moulds. among the dermatophytes, the most common pathogen isola ...201119925570
tinea capitis: still an unsolved problem?tinea capitis is a fungal infection specifically involving the scalp and hair. it is the most common dermatophyte infection in children under 12 years of age, with a predominance in those of sub-saharan african descent. common signs include hair loss, scaling, erythema and impetigo-like plaques. adults may also be affected, but to a lesser degree. the causative species are from the microsporum and trichophyton genera. limited treatment options and diverse modes of transmission complicate the cli ...201120002884
use of itraconazole and either lime sulphur or malaseb concentrate rinse ® to treat shelter cats naturally infected with microsporum canis: an open field trial.in an open non-randomized study, 90 cats with severe dermatophytosis were treated with 21 days of oral itraconazole at 10 mg/kg and one of three topical antifungal rinses applied twice weekly: lime sulphur (lso); reformulated lime sulphur with an odour-masking agent (lsr); or a 0.2% miconazole nitrate and 0.2% chlorhexidine gluconate rinse (mc). weekly examinations and fungal cultures were used to monitor the cats' response to therapy. if at day 42 of treatment cats were still strongly fungal cu ...201120604908
guidelines for the management of tinea capitis in children.practice guidelines for the treatment of tinea capitis (tc) from the european society for pediatric dermatology are presented. tinea capitis always requires systemic treatment because topical antifungal agents do not penetrate the hair follicle. topical treatment is only used as adjuvant therapy to systemic antifungals. the newer oral antifungal agents including terbinafine, itraconazole, and fluconazole appear to have efficacy rates and potential adverse effects similar to those of griseofulvin ...201020609140
the frequency of superficial mycoses according to agents isolated during a ten-year period (1999-2008) in zagreb area, croatia.fungal infections involving the skin, hair and nails represent one of the most common mucocutaneous infections. significant changes in the epidemiology, etiology and clinical pattern of mycotic infections have been observed during the last years. the aim of this retrospective study was to determine the incidence and the etiologic factors of superficial fungal infections in zagreb area, croatia, over a 10-year period (1999-2008). a total of 75828 samples obtained from 67 983 patients were analyze ...201020624358
identification and characterisation of human pathogenic filamentous fungi and susceptibility to thymus schimperi essential oil.summary twenty-eight clinical fungal isolates were characterised by morphological (macro- and micro-features and growth response at 25, 30 and 37 degrees c) and molecular (nuclear rdna-internal transcriber spacer, calmodulin, cytochrome c oxidase 1 and the largest subunit of rna polymerase ii) analyses. the clinical fungal isolates were ascribed to the following taxa: penicillium chrysogenum, verticillium sp., aspergillus tubingensis, aspergillus minutus, beauveria bassiana and microsporum gypse ...201020633233
evaluation of the association of superficial dermatophytosis and athletic activities with special reference to its prevention and control.this study was conducted to evaluate the association of superficial mycosis and athletic activities with special references to its prevention and control in tehran. participating in various kinds of sports can lead to direct and indirect exposures to and transmission of micro-organisms between athletes and also passive observers.201020636349
prevalence and causative fungal species of tinea capitis among schoolchildren in gabon.summary tinea capitis is endemic among schoolchildren in tropical africa. the objective was to determine the prevalence of symptomatic tinea capitis in schoolchildren in gabon. a cross-sectional study was conducted with 454 children aged 4-17 years, attending a rural school and an urban school. the diagnosis of tinea capitis was based on clinically manifest infection, direct microscopic examination using 20% potassium hydroxide (koh) solution and fungal culture. based on clinical examination, 10 ...201020637052
in vivo antifungal effect of combretum and terminalia species extracts on cutaneous wound healing in immunosuppressed rats.acetone leaf extracts of combretaceae species combretum imberbe wawra, combretum nelsonii duemmer, combretum albopunctatum suesseng, and terminalia sericea burch ex dc and a mixture of asiatic acid and arjunolic acid isolated from c. nelsonii were tested for antifungal activity against candida albicans, cryptococcus neoformans, microsporum canis, and sporothrix schenckii on wounds of immunocompromised wistar rats. the therapeutic agents were selected based on low mic values ranging 0.02-2.5 mg/m ...201020645734
antifungal activity of extracts and prenylated coumarins isolated from baccharis darwinii hook & arn. (asteraceae).the petroleum ether extract of baccharis darwinii showed activity against cryptococcus neoformans and dermatophytes. bioactivity-guided fractionation of baccharis darwinii has resulted in the isolation of three coumarins: 5'-hydroxy aurapten (anisocoumarin h, 1), aurapten (7-geranyloxycoumarin, 2) and 5'-oxoaurapten (diversinin, 3). the structures of these compounds were characterized by spectroscopic methods. these compounds were evaluated for their antimicrobialactivity against a panel of each ...201020657398
extraction, separation and isolation of volatiles from vitex agnus-castus l. (verbenaceae) wild species of sardinia, italy, by supercritical co2.isolation of volatile concentrates from leaves, flowers and fruits of vitex agnus-castus l. have been obtained by supercritical extraction with carbon dioxide. the composition of the volatile concentrates has been analysed by gc/ms. in all plant organs, the extracts are composed chiefly of alpha-pinene, sabinene, 1,8-cineole, alpha-terpinyl acetate, (e)-caryophyllene, (e)-beta-farnesene, bicyclogermacrene, spathulenol and manool. the main difference observed was in the content of sclarene, which ...201020397107
[dermatophytoses due to anthropophilic fungi in cadiz, spain, between 1997 and 2008].cutaneous fungal infections are a major public health problem. the distribution of the dermatophytoses varies between countries and geographical areas. the aim of this study was to determine the incidence, epidemiology, etiology, and clinical course of the dermatophytoses caused by anthropophilic fungi in cadiz, spain, over the past 12 years.201020398600
majocchi granuloma caused by microsporum canis as tinea incognito. 201020406391
incidence of keratinophilic fungi from the soils of vedanthangal water bird sanctuary (india).summary fifty-three soil samples were collected from various sites in the vicinity of vedanthangal water bird sanctuary and screened for the presence of keratinophilic fungi using the hair baiting techniques for isolation. twenty-eight isolates were recovered and identified by recognition of their macro- and micromorphological features. seven species related to five genera were recorded viz. auxarthron conjugatum (1.89%), chrysosporium fluviale (3.77%), chrysosporium indicum (20.75%), chrysospor ...201020406397
favus of the scalp: an overview and update.tinea capitis favosa, a chronic inflammatory dermatophyte infection of the scalp, affects over 90% of patients with anthropophilic trichophyton schoenleinii. t. violaceum, t. verrucosum, zoophilic t. mentagrophytes (referred to as 'var. quinckeanum'), microsporum canis, and geophilic m. gypseum have also been recovered from favic lesions. favus is typically a childhood disease, yet adult cases are not uncommon. interestingly, favus is less contagious than other dermatophytoses, although intrafam ...201020411336
development of efficient tools for genetic manipulation of dermatophytes.molecular biological approaches have recently begun to be applied to molecular genetics studies of dermatophytes. high-throughput gene analysis methodologies, such as est sequencing, differential cdna screening, and cdna-based microarray analysis have been used to obtain information on many dermatophyte genes and their expression profiles under different experimental conditions. in addition, whole genome sequencing projects are underway for several important dermatophytes, such as trichophyton r ...201020467196
[epidemiological and clinical characteristics of intestinal microsporidiosis].intestinal microsporidiosis is an opportunistic parasitological infection affecting mainly immunocompromised patients, particularly those infected with hiv.201020483704
[emergence of microsporum audouinii and trichophyton tonsurans as causative organisms of tinea capitis in the dominican republic].tinea capitis affects mainly children. the frequency and causative organism vary from region to region.201020487688
fungalysin and dipeptidyl-peptidase gene transcription in microsporum canis strains isolated from symptomatic and asymptomatic cats.microsporum canis is the main pathogenic fungus that causes a superficial cutaneous infection called dermatophytosis in domestic carnivores. in cats, m. canis causes symptomatic or asymptomatic infection. recent conflicting data raise the question of whether the clinical status of the infected cat (symptomatic or asymptomatic) is directly correlated to the proteolytic activity of m. canis strains. here, the transcription of fungalysin and dipeptidyl-peptidase genes (dpp) of m. canis was compared ...201020488631
tinea corporis mimicking herpes zoster. 201020492537
tinea capitis in adults in tunisia.objective: to determine the pattern of infectious agents causing tinea capitis (tc) in adult patients in the center of tunisia. methods: from january 1990 to december 2005, we have retrospectively collected all cases of adult tc, confirmed by the mycological examination. results: sixty patients (18 male, 42 female) with a mean age of 34.5 years were diagnosed as having adult tc among a total number of 1137 cases of tc (5.27%). clinical features were polymorphic and diagnosis was made on mycologi ...201020534084
inflammatory tinea capitis: non-healing plaque on the occiput of a 4-year-old child.inflammatory tinea capitis is an uncommon condition in singapore. in this case report we present a patient whom we managed for this condition.201020535434
synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-n-(4,6-diarylpyrimidin-2-yl)acetamides.biolabile 2-morpholino-n-(4,6-diarylpyrimidin-2-yl)acetamides 34-42 have been synthesized and evaluated for their in vitro antibacterial and antifungal activities. the minimum inhibitory concentration tested for the same compounds against the same set of bacterial and fungal strains shows that the compounds 36 and 38 against beta-heamolytic streptococcus and klebsiella pneumonia, 40 against escherichia coli and pseudomonas, have excellent antibacterial activity. compounds 36, 38 and 42 show inhi ...201020106563
recovery of dermatophytes in pet grooming tools from veterinary clinics and pet grooming salons.fomites such as brushes and clippers are known to be potential risk factors for the transmission of dermatophytes between pet animals. the aim of this study was to investigate this risk by examining those grooming implements for the presence of any viable dermatophytes.201020137008
cutaneous mycoflora and cd4:cd8 ratio of cats infected with feline immunodeficiency virus.this study was designed to compare cutaneous mycoflora isolation and cd4+:cd8+ ratio in feline immunodeficiency virus (fiv)-infected cats with that in fiv-uninfected cats. sixty cats were examined. twenty-five were fiv-infected cats and 35 were fiv-uninfected cats. all 60 cats were felv-negative. fungi were speciated and immunophenotyping of peripheral cd4+ and cd8+ t lymphocytes was performed. at least one fungal colony was isolated from 22/25 (88%) fiv-infected cats. among the fiv-uninfected c ...201020156698
cd4+ and cd8+ t cells mediated direct cytotoxic effect against trichophyton rubrum and trichophyton mentagrophytes.the cellular immune system is the most dominant factor in curing acute dermatophytosis. however, the exact immune mechanisms involved in generating this defense are complex and still obscure. the aim of this study was to investigate the fungicidal mechanism of t cells in the normal population versus patients with chronic fungal infections.201019968718
secreted subtilisin sub3 from microsporum canis is required for adherence to but not for invasion of the epidermis.microsporum canis is a pathogenic dermatophyte that causes a superficial cutaneous mycosis, mainly in cats and humans. proteolytic enzymes, including subtilisins, have been postulated to be key factors involved in adherence and invasion of the stratum corneum and keratinized epidermal structures.201019995373
synthesis and antifungal activity of 1-aryl-3-phenethylamino-1-propanone hydrochlorides and 3-aroyl-4-aryl-1-phenethyl-4-piperidinols.mono-mannich bases, 1-aryl-3-phenethylamino-1-propanone hydrochlorides, 1a, 2a, 3a, 4a, 5a, 6a, 7a, 8a, 9a, and semi-cyclic mono-mannich bases, 3-aroyl-4-aryl-1-phenethyl-4-piperidinols, 1b, 2b, 3b, 4b, 5b, 6b, 7b, 8b, 9b, were synthesized by a non-classical mannich reaction. the aryl part was: c(6)h(5 )for 1a, 1b; 4-ch(3)c(6)h(4) for 2a, 2b; 4-ch(3)oc(6)h(4 )for 3a, 3b; 4-clc(6)h(4 )for 4a, 4b; 4-fc(6)h(4) for 5a, 5b; 4-brc(6)h(4) for 6a, 6b; 2,4-(cl)(2)c(6)h(3) for 7a, 7b; 4-no(2)c(6)h(4 )for ...201020232370
does this young girl have the same rash as her mother? 201020232720
Refresh
firstprev
12345678910...
nextlast
Displaying items 1 - 100 of 3121