Publications

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antifungal activity of lactobacillus against microsporum canis, microsporum gypseum and epidermophyton floccosum.a total of 220 lactic acid bacteria isolates were screened for antifungal activity using aspergillus fumigatus and aspergillus niger as the target strains. four lactobacillus strains exhibited strong inhibitory activity on agar surfaces. all four were also identified as having strong inhibitory activity against the human pathogenic fungi microsporum canis, microsporum gypseum and epidermophyton floccosum. one of the four lactobacilli, namely lb. reuteri ee1p exhibited the most inhibition against ...201722539027
nimesulide inhibits pathogenic fungi: pge2-dependent mechanisms.certain non-steroidal anti-inflammatory drugs can inhibit fungal growth, fungal prostaglandin e2 production, and enzyme activation. this study aims to investigate the antifungal effect of nimesulide against pathogenic filamentous fungi and yeast. the experiments detailed below were also designed to investigate whether the action is dependent on e2 fungal prostaglandins. our data showed that nimesulide exhibited potent antifungal activity, mainly against trichophyton mentagrophytes (atcc 9533) an ...201727866353
enzymatic and non-enzymatic virulence activities of dermatophytes on solid media.dermatophytes are keratinophilic fungi causing superficial cutaneous infections that account 20-25% of the global population. as per literature search, there is a dearth in the study on virulence factors of dermatophytes from the indian sub-continent and moreover the association of the virulence factors and the host tissue in vitro helps in understanding the host-pathogen interaction.201728384862
antidermatophytic and protease-inhibiting activities of zerumbone: a natural sesquiterpene from the rhizome of zingiber zerumbet (l.) roscoe ex j.e; smith.due to increase in the number of patients with impaired immunity, incidence of dermatophytoses has increased considerably. antidermatophytic agents with anti-inflammatory and protease-inhibiting activities will help in restricting inflammatory response associated with dermatophytoses.201728216875
toward a novel multilocus phylogenetic taxonomy for the dermatophytes.type and reference strains of members of the onygenalean family arthrodermataceae have been sequenced for rdna its and partial lsu, the ribosomal 60s protein, and fragments of β-tubulin and translation elongation factor 3. the resulting phylogenetic trees showed a large degree of correspondence, and topologies matched those of earlier published phylogenies demonstrating that the phylogenetic representation of dermatophytes and dermatophyte-like fungi has reached an acceptable level of stability. ...201727783317
the changing face of dermatophytic infections worldwide.dermatophytes evolve along with the geography and socioeconomic conditions. epidermophyton floccosum, microsporum audouinii and trichophyton schoenleinii acted as the major pathogens of superficial fungal diseases 100 years ago, but their frequency decreased dramatically since the middle of the twentieth century and they are limited to some less-developed countries nowadays; meanwhile, frequency of trichophyton rubrum, trichophyton interdigitale, trichophyton tonsurans and microsporum canis incr ...201727783316
inhibition of dermatophytes by photodynamic treatment with curcumin.treatment of dermatophytoses with currently available antimycotic agents is often tedious and sometimes unsatisfactory. a search for better therapeutic methods-ideally with an immediate fungicidal effect-has, among others, lead to photodynamic procedures as a promising alternative, and recently curcumin was found to be a suitable agent for this application. in this study the effect of photodynamic treatment with curcumin on dermatophytes was tested in vitro wells of microtiter plates were filled ...201728053148
chemical characterisation and biological activity of leaf essential oils obtained from pistacia terebinthus growing wild in tunisia and sardinia island.in the present work the chemical compositions, measured by gc and gc-ms, of the essential oils obtained by hydrodistillation from leaves of pistacia terebinthus collected in bizerte (tunisia) and baunei (italy) are reported. both essential oils possessed high content of monoterpene hydrocarbons (86.3% and 90.9%, respectively), being α-pinene (62.4 vs. 35.0)%, camphene (3.0 vs. 2.4)%, β-pinene (12.1 vs. 4.5)%, terpinolene (1.7 vs. 35.2)% and β-phellandrene (3.8 vs. 4.5)% the main components. the ...201728278668
preparation and physicochemical characterization of topical chitosan-based film containing griseofulvin-loaded liposomes.griseofulvin is an antifungal drug and is available as oral dosage forms. development of topical treatment could be advantageous for superficial fungal infections of the skin. in this study, films prepared from the incorporation of griseofulvin-loaded liposomes in chitosan film for topical drug delivery in superficial fungal infections. the properties of the films were characterized regarding mechanical properties, swelling, ability to transmit vapor, drug release, thermal behavior, and antifung ...201727429928
anti-dermatophyte activity of leguminosae plants from southern brazil with emphasis on mimosa pigra (leguminosae).intensive prophylactic use of antifungals leads to the increase of drug resistance and the need for new and more effective treatments are real. plants from leguminosae family are rich in flavonoids, for which numerous biological activities have been described, including antifungal effects.201728822705
dermatophytosis of the scrotum, penis and lip.a young male had tinea cruris due to epidermophyton floccosum. he had associated dermatophytosis of the scrotum, penis and upper lip from which the same species of fungus was isolated. on the lip, the lesion extended to the vermilion area (prolabium) of the lip and the term 'tinea labialis' is suggested for this condition.201728145332
clinico mycological study of dermatophytosis in a coastal area.clinico-mycological features of one hundred patients suffering from tinea cruris are reported. ninety two per cent are males and 79% are in the age group of 11-39 years. involvement of axillae is seen in four penile involvement in five patients. 'twenty-eight patients have tinea corporis and nine tinea vesicolor also. seventy seven patients show isolation of dernm-tophytes by culture. the commonest species of dermatophytes is trichophyron rubrum (57.1%) followed by t. mentagraphytes (31.20/o), e ...201728176711
mycology of cutaneous fungal infections in ambajogai: a rural area.two hundred and eithteen cases of fungal skin infections were studied. tinea cruris was most common (34.4%), followed by tinea corporis (23.8%) znd tinea pedis (21.6%). tinea versicolor (8.7%) tinea manum (4.6%) tinea ungaium (3.7%) and tinea capitis (3.2%) were also seen. the male: female ratio was 4:1. the total isolates were 117. trichophyton rubrum was the most common isolate (35%). closely followed by epidermophyton floccosum (31.6%). trichphyton mentagrophytes (17.9%), malassezia furfur (1 ...201728211405
distribution of species of dermatophyte among patients at a dermatology centre of nghean province, vietnam, 2015-2016.vietnam is a tropical country so fungal diseases including dermatophytosis may be prevalent, but epidemiological profiles of agents responsible for the infection have rarely been reported.201728831770
diagnosis of dermatophytosis by conventional methods and comparatative analysis of sabouraud dextrose agar and dermatophyte test medium for isolation of dermatophytes.dermatophytosis is a fungal disease which ranked as one of the most common cutaneous condition in all over the world. the aim of this cross sectional observational study is to identify the etiological agent of dermatophytosis and comparison of sabouraud dextrose agar (sda) and dermatophyte test medium (dtm) for the primary isolation of dermatophytes among the clinically suspected cases of dermatophytosis from the outpatient department of dermatology and venereology, mymensingh medical college ho ...201728588164
evaluation of incubation time for dermatophytes cultures.in general, it is recommended to incubate dermatophytes cultures for a minimum of 4 weeks. several aspects of routine fungal cultures should be evaluated in order to implement appropriate and necessary changes. the aim of this study was to determine the optimum incubation time for routine dermatophytes cultures, analysing the time to find first fungal growth by visual observation. we recorded the time when the initial growth was detected for all dermatophyte isolates during a 4-year period. a to ...201627144472
species identification of dermatophytes in paraffin-embedded biopsies with a new polymerase chain reaction assay targeting the internal transcribed spacer 2 region and comparison with histopathological features.dermatophytosis is a very common skin infection with a broad clinical spectrum. biopsies are often used to confirm the diagnosis, especially when the clinical presentation is unusual. not uncommonly, organisms are hard to find even with periodic acid-schiff stains. polymerase chain reaction (pcr) for dermatophytes can be used in such cases.201626556042
antifungal susceptibility and virulence factors of clinically isolated dermatophytes in tehran, iran.dermatophytes possess a wide array of virulence factors and various antifungal susceptibility patterns which influence their pathogenesis in humans and animals. the aim of this study was to evaluate antifungal susceptibility and keratinase and proteinase activity of 49 dermatophyte strains from the genera microsporum, trichophyton and epidermophyton which were isolated from human cases of dermatophytosis.201627092223
epidemiological trends of dermatophytosis in tehran, iran: a five-year retrospective study.dermatophytosis is the most frequent fungal infection all over the world and its frequency is constantly increasing. the aim of this study was to evaluate clinical features and epidemiological trends of dermatophytosis over the years 2010 to 2014 in tehran, iran.201627520535
epidemiological aspects of dermatophytosis in khuzestan, southwestern iran, an update.dermatophytosis is among the most common superficial mycoses in iran. the purpose of this report was to update the clinical and mycological features of human dermatophytosis in the khuzestan, southwestern iran. in the framework of a one-year survey, a total of 4120 skin, hair and nail samples obtained from the outpatients with symptoms suggestive of tinea were analyzed by using direct microscopy, culture and molecular identification methods. strains isolated from cultures were subjected to ampli ...201626886443
epidemiology of dermatophytoses in crete, greece.dermatophytoses are among the most frequently diagnosed skin infections worldwide. however, the distribution of pathogenic species and the predominating anatomical sites of infection vary with geographical location and change over time. the aim of this study was to determine the epidemiological and aetiological factors of dermatophytoses in crete, greece over the last 5-year period (2011-2015) and their incidence in relation to the gender and the age of the patients. we compared our findings wit ...201627904054
epidemiology of tinea capitis in northeast iran: a retrospective analysis from 1998 to 2012.tinea capitis is a common disease of the pediatric population. this disease typically follows one of several clinical patterns, i.e., scaling, hair loss, and/or inflammatory lesions, which are usually caused predominantly by two dermatophytic genera: microsporum and trichophyton. the aim of this study was to investigate tinea capitis and its etiological agents in sari city of mazandaran province, iran.201626440755
detection of common dermatophytes in clinical specimens using a simple quantitative real-time taqman polymerase chain reaction assay.dermatophytes are common fungal pathogens causing mostly superficial infections in humans with a high prevalence worldwide. traditional detection techniques are time-consuming and insensitive, whereas molecular detection methods have proved to be much more rapid and sensitive.201626406273
molecular characterization and in vitro antifungal susceptibility of 316 clinical isolates of dermatophytes in iran.dermatophytosis is a common mycotic infection of the skin, nail, and hair, associated with major public health concern worldwide. various species of dermatophytes show significant differences in susceptibility to antifungals. here, we present the antifungal susceptibility of a large collection of molecularly identified dermatophyte isolates obtained from tropical region of south of iran. a total of 9485 patients clinically suspected to have cutaneous fungal infections were examined. dermatophyto ...201626369643
a 10-year study of dermatophytoses in isfahan, iran.dermatophyte infections are very common worldwide and their epidemiological characteristics vary according to the geographical region and have altered in the last decades. the aim of the present investigation was to determine the diversity of causative agents of dermatophytoses and describe the epidemiological condition of infection in isfahan, iran, between 2003 and 2012. specimens were collected from hair, nail, and skin and were examined by conventional methods such as direct microscopy, cult ...201625902908
multilaboratory evaluation of in vitro antifungal susceptibility testing of dermatophytes for me1111.me1111 is a novel small molecule antifungal agent under development for the topical treatment of onychomycosis. standardization of the susceptibility testing method for this candidate antifungal is needed. toward this end, 8 independent laboratories determined the interlaboratory reproducibility of me1111 susceptibility testing. in addition, we subsequently identified 2 strains as quality control (qc) isolates for the method. in the reproducibility study, 5 blinded clinical strains each of trich ...201626719434
antidermatophytic activity of ethanolic extract from croton tiglium.dermatophytosis, which is caused mainly by genera of trichophyton, epidermophyton, and microsporum, is a frequent dermatological problem in tropical and subtropical countries. investigations were carried out in this study to evaluate the antidermatophytic activity of the stems, leaves, and seeds of croton tiglium, one of the traditional medicine plants indigenous to asia. ethanolic extracts of the stems, leaves, and seeds of c. tiglium were prepared by cold soak or heat reflux methods. the antid ...201627446946
molecular identification and phylogenetical analysis of dermatophyte fungi from latin america.dermatophytes constitute a complex group of fungi, comprised of by the genera trichophyton, epidermophyton and microsporum. they have the ability to degrade keratin and cause human and animal infections. molecular techniques have made their identification faster and more accurate, and allowed important advances in phylogenetic studies. we aim to identify molecularly and to determine the phylogenetic relationships in dermatophyte fungi from brazil and other latin american countries, using dna seq ...201627432316
antidermatophytic action of resorcinol derivatives: ultrastructural evidence of the activity of phenylethyl resorcinol against microsporum gypseum.in this work, we evaluated the antidermatophytic activities of three resorcinol derivatives that have a history of use in dermo-cosmetic applications to discover molecules with multiple dermatological activities (i.e., multi-target drugs), thereby reducing the cost and time necessary for new drug development. the antidermatophytic activities of the three skin lighteners were evaluated relative to the known antifungal drug fluconazole on nine dermatophytes responsible for the most common dermatom ...201627706019
econazole nitrate foam 1% improves the itch of tinea pedis.econazole nitrate topical foam, 1%, is indicated for the treatment of interdigital tinea pedis caused by <em>trichophyton rubrum, trichophyton mentagrophytes,</em> and <em>epidermophyton floccosum</em> in patients 12 years of age and older. the symptom of itch or pruritus was evaluated in two randomized, double-blind, parallel-group, vehicle-controlled, multicenter phase iii studies in which econazole foam was compared with foam vehicle in subjects with interdigital tinea pedis. a thin, uniform ...201627602974
[superficial mycoses: casuistry of the mycology department of the instituto nacional de higiene "rafael rangel", caracas, venezuela (2001-2014)].the superficial mycoses are very common infectious diseases and therefore are a frequent reason for medical consultation. the aim of this study was to determine the diagnostic frequency of superficial mycoses in the mycology department of the instituto nacional de higiene "rafael rangel" during 14 years (2001-2014). a retrospective cross-sectional study was performed to review the mycological records of patients with presumptive diagnosis of superficial mycosis. nails, hairs and epidermal scales ...201627382801
computational analysis of conserved coil functional residues in the mitochondrial genomic sequences of dermatophytes.dermatophyte is a group of closely related fungi that have the capacity to invade keratinized tissue of humans and other animals. the infection known as dermatophytosis, caused by members of the genera microsporum, trichophyton, and epidermophyton includes infection to the groin (tinea cruris), beard (tinea barbae), scalp (tinea capitis), feet (tinea pedis), glabrous skin (tinea corporis), nail (tinea unguium), and hand (tinea manuum). the identification of evolutionary relationship between thes ...201628149055
sensitization and cross-reactions of dermatophyte and candida albicans allergens in patients with chronic urticaria.chronic fungal infections are known to exacerbate allergic symptoms, including those of asthma and chronic urticaria (cu). we applied four prepared fungal antigens of trichophyton rubrum, trichophyton mentagrophytes, epidermophyton floccosum, and candida albicans to examine sensitization to each in subjects with cu and onychomycosis and in healthy subjects, and to evaluate the etiologic role of dermatophytic infection in cu and observe any cross-reactions among these four antigens.201627420771
superficial mycoses associated with diaper dermatitis.diapers create particular conditions of moisture and friction, and with urine and feces come increased ph and irritating enzymes (lipases and proteases). fungi can take advantage of all these factors. candida yeasts, especially c. albicans, are responsible for the most frequent secondary infections and are isolated in more than 80 % of cases. correct diagnosis is important for ensuring the correct prescription of topical antimycotics. nystatin, imidazoles and ciclopirox are effective. it is impo ...201627193417
characterization of clinically important dermatophytes in north of iran using pcr-rflp on its region.dermatophytosis is considered as one of the major public health problems in the world. accurate identification of the dermatophytes species is important for recognition of the environment and animal sources of infection. in this survey, 1500 clinical specimens taken from outpatients suspected of dermatophytosis and they were examined by direct microscopy and culture.201627496524
phylogenetic analysis of dermatophyte species using dna sequence polymorphism in calmodulin gene.use of phylogenetic species concepts based on rdna internal transcribe spacer (its) regions have improved the taxonomy of dermatophyte species; however, confirmation and refinement using other genes are needed. since the calmodulin gene has not been systematically used in dermatophyte taxonomy, we evaluated its intra- and interspecies sequence variation as well as its application in identification, phylogenetic analysis, and taxonomy of 202 strains of 29 dermatophyte species. a set of primers wa ...201626868901
sporicidal effect of amorolfine and other antimycotics used in the therapy of fungal nail infections.although topical antifungal therapies for treating onychomycosis are available, the cure rate is unsatisfactorily low with a simultaneously high risk of recurrence. one reason might be the formation of dormant fungal cells by the pathogen, known as spores, which can survive in the affected nail keratin, thereby evading the effect of antifungal drugs. in this in vitro study, the ability of amorolfine and four other antimycotics (ciclopirox, bifonazole, terbinafine and fluconazole) to kill microco ...201526334024
artemisia herba-alba essential oil from buseirah (south jordan): chemical characterization and assessment of safe antifungal and anti-inflammatory doses.artemisia herba-alba asso ("desert wormwood" in english; "armoise blanche" in french; "shaih" in arabic), is a medicinal and strongly aromatic plant widely used in traditional medicine by many cultures since ancient times. it is used to treat inflammatory disorders (colds, coughing, bronchitis, diarrhea), infectious diseases (skin diseases, scabies, syphilis) and others (diabetes, neuralgias). in jordanian traditional medicine, this plant is used as antiseptic and against skin diseases, scabies, ...201526277492
dermatophyte and non dermatophyte fungi in riyadh city, saudi arabia.dermatophytes are a scientific label for a group of three genera (microsporum, epidermophyton and trichophyton) of fungus that causes skin disease in animals and humans. conventional methods for identification of these fungi are rapid and simple but are not accurate comparing to molecular methods.201526288566
in vitro antifungal activity of some traditional persian medicinal plants on pathogenic fungi.to investigate the antifungal activities of the extracts and sub-fractions of phlomis olivieri, verbascum speciosum, sambucus ebulus and erigeron hyrcanicus, four persian medicinal plants used in iranian folk medicine.201526129901
novel triazole alcohol antifungals derived from fluconazole: design, synthesis, and biological activity.a series of new triazole alcohol antifungals were designed by replacing one of the triazolyl moiety from fluconazole with a distinct 4-amino-3-mercapto-1,2,4-triazole motif, which is found in some antimicrobial agents. the antimicrobial susceptibility testing of target compounds demonstrated that the direct analogs of fluconazole (difluorophenethyl-triazoles) were less active against fungi, while compound 10h containing dichloro substitutions on both phenyl rings of the molecule had potent activ ...201525182365
hemolytic activity of dermatophytes species isolated from clinical specimens.hemolytic activity was recently reported for several pathogenic fungal species, such as aspergillus, candida, trichophyton, penicillium and fusarium. based on a number of mechanistic and characterization studies, several fungal hemolysins have been proposed as virulence factors. hemolysins lyse red blood cells resulting in the release of iron, an important growth factor for microbes especially during infection. the requirement of iron in fungal growth is necessary for metabolic processes and as ...201525467819
myrtus communis l. as source of a bioactive and safe essential oil.in algeria, myrtus communis l. is distributed throughout the tell atlas and the coastal regions of algiers and constantine. the leaves are used in respiratory disorders, diarrhea and hemorrhoids. the aims of this work were to evaluate the antifungal and anti-inflammatory potential of well characterized essential oils (eo). since eo can be applied by inhalation, dermal application and oral administration, we used several mammalian cell lines to assess safe bioactive doses. the chemical compositio ...201525446467
isolation of dermatophytes (and other fungi) from human nail and skin dust produced by podiatric medical treatments in australia.podiatric physicians routinely use electric drills for the treatment of nail and skin conditions. the grinding process produces human nail and skin dust that is generally vacuumed into bags in the grinding unit. many of the nails are thought to be mycotic, particularly because they are obtained from patients with symptoms of dermatophyte infections. currently, there is limited information available on the detection of fungi from nail dust samples. herein, we attempt to address this situation and ...201525815649
in vitro susceptibility patterns of clinically important trichophyton and epidermophyton species against nine antifungal drugs.despite the common, worldwide, occurrence of dermatophytes, little information is available regarding susceptibility profiles against currently available and novel antifungal agents. a collection of sixty-eight clinical trichophyton species and epidermophyton floccosum were previously identified and verified to the species level by sequencing the internal transcribed spacer (its) regions of rdna. mics of amphotericin b, fluconazole, itraconazole, voriconazole, posaconazole, isavuconazole, terbin ...201525757042
dermatophytosis: a 16-year retrospective study in a metropolitan area in southern brazil.dermatophytoses are considered a public health problem. the objectives of this study were to determine the evolution of their prevalence in the metropolitan area of porto alegre, brazil, and to analyze the dermatophyte species distribution according to body site and demographic characteristics of the patients.201526322879
use of restriction fragment length polymorphism to rapidly identify dermatophyte species related to dermatophytosis.dermatophytes are a group of keratinophilic fungi worldwide, which can infect the skin, hair and nails of humans and animals. this genus includes several species that present different features of dermatophytosis. although, laboratory diagnosis of dermatophytes is based on direct microscopy, biochemical tests and culture, these manners are expensive, time consuming and need skilled staff. therefore, molecular methods like pcr-rflp are the beneficial tools for identification, which are rapid and ...201526301058
inhibitory effect of silver nanoparticles mediated by atmospheric pressure air cold plasma jet against dermatophyte fungi.in an in vitro study with five clinical isolates of dermatophytes, the mic(50) and mic(100) values of silver nanoparticles (agnps) ranged from 5 to 16 and from 15 to 32 μg ml(- 1), respectively. the combined treatment of agnps with atmospheric pressure-air cold plasma (apacp) induced a drop in the mic(50) and mic100 values of agnps reaching 3-11 and 12-23 μg ml(- 1), respectively, according to the examined species. epidermophyton floccosum was the most sensitive fungus to agnps, while trichophyt ...201526296782
a multi-target approach toward the development of novel candidates for antidermatophytic activity: ultrastructural evidence on α-bisabolol-treated microsporum gypseum.multi-target strategies are directed toward targets that are unrelated (or distantly related) and can create opportunities to address different pathologies. the antidermatophytic activities of nine natural skin lighteners: α-bisabolol, kojic acid, β-arbutin, azelaic acid, hydroquinone, nicotinamide, glycine, glutathione and ascorbyl tetraisopalmitate, were evaluated, in comparison with the known antifungal drug fluconazole, on nine dermatophytes responsible for the most common dermatomycoses: mi ...201526132903
chemical analysis and in vitro antiviral and antifungal activities of essential oils from glechon spathulata and glechon marifolia.glechon spathulata benth. and glechon marifolia benth. (lamiaceae, mentheae) are aromatic plants used in traditional medicine for the treatment of viral infections.201525431185
identification of dermatophilus congolensis from lower leg dermatitis of cattle in kerala, india.this study was conducted to identify the aetiological agents associated with a particular type of lower leg dermatitis, locally called pododermatitis, among dairy cattle in kerala. skin scabs and scrapings were collected aseptically from 82 naturally occurring cases of lower leg dermatitis in cattle and were subjected to direct microscopical examination and bacterial and fungal culture. microscopical examination of the skin scrapings with 10% potassium hydroxide revealed fungal spores in hair sh ...201527044156
induction by epidermophyton floccosum of human fibroblast matrix metalloproteinase-9 secretion in vitro.skin infection from pathogenic dermatophyte, epidermophytonfloccosum, can cause serious health complications, especially in immuno-compromised patients. proteolytic enzymes secreted from e. floccosum are required for host tissue degradation, facilitating fungal invasion. however, little is known regarding host matrix metalloproteinase (mmp) expression during e. floccosum infection. in this study human foreskin fibroblast (hff) cell line was used to determine mmp-9 protease activity by gelatin zy ...201526513930
pattern of dermatophytes in patients attend in mymensingh medical college hospital.dermatophytosis is a common fungal disease which involves the keratinized tissue. this is an attempt to observe the spectrum of dermatophytes among the clinically suspected cases of dermatophytosis attending the outpatient department of dermatology and venereology, mymensingh medical college hospital, mymensingh during the period of july 2013 to december 2014. two hundred thirty (230) clinically suspected cases of dermatophytosis were subjected in this study. sixty three cases (27.39%) were posi ...201526620004
[2011 epidemiological survey of dermatomycoses in japan].an epidemiological survey of dermatomycoses and their causative fungus flora in japan for 2011 was conducted in accordance with methods and criteria of the past four surveys. the survey covered a total number of 36,052 outpatients who visited 12 dermatological clinics throughout japan. the results were as follows. 1）dermatophytosis was the most prevalent cutaneous fungal infection (2,980 cases) seen in these clinics, followed by candidiasis (378 cases) and then malassezia infections (152 cases). ...201526617109
antidermatophytic activity of mikania micrantha kunth: an invasive weed.the incidence of dermatophytosis has risen dramatically in recent years. limited availability of side-effect free drugs has led to a search for new antidermatophytic agents.201526109783
anti-dermatophyte efficacy and environmental safety of some essential oils commercial and in vitro extracted pure and combined against four keratinophilic pathogenic fungi.establish new biocontrol practices with low persistence in the environment against dermatophyte causing mycosis.201525953414
isolation of dermatophytes (and other fungi) from human nail and skin dust produced by podiatric medical treatments in australia.background: podiatric physicians routinely use electric drills for the treatment of nail and skin conditions. the grinding process produces human nail and skin dust that is generally vacuumed into bags in the grinding unit. many of the nails are thought to be mycotic, particularly because they are obtained from patients with symptoms of dermatophyte infections. currently, there is limited information available on the detection of fungi from nail dust samples. herein, we attempt to address this s ...201525647477
antimicrobial and antioxidant activities and chemical characterization of essential oils of thymusvulgaris, rosmarinus officinalis, and origanum majorana from northeastern méxico.there have been no reports of antifungal activity and composition of extracts from thymus vulgaris, rosmarinus officinalis or origanum majorana from northeastern méxico. antifungal activity of these oils against trichophyton rubrum, trichophyton tonsurans, trichophyton mentagrophytes, microsporum gypseum, microsporum canis and epidermophyton floccosum was measured by diffusion assay. additionally, antibacterial and antioxidant activities were evaluated. antibacterial activity against staphylococ ...201525631514
translation elongation factor 1-α gene as a potential taxonomic and identification marker in dermatophytes.intra- and interspecies variations of the translation elongation factor 1-α (tef-1α) gene were evaluated as a new identification marker in a wide range of dermatophytes, which included 167 strains of 30 species. an optimized pan-dermatophyte primer pair was designed, and the target was sequenced. consensus sequences were used for multiple alignment and phylogenetic tree analysis and the levels of intra- and interspecific nucleotide polymorphism were assessed. between species, the analyzed part o ...201525550390
tinea pedis: the etiology and global epidemiology of a common fungal infection.tinea pedis, which is a dermatophytic infection of the feet, can involve the interdigital web spaces or the sides of the feet and may be a chronic or recurring condition. the most common etiological agents are anthropophiles, including trichophyton rubrum sensu stricto, which is the most common, followed by trichophyton interdigitale and epidermophyton floccosum. there has been a change in this research arena, necessitating a re-evaluation of our knowledge on the topic from a multidisciplinary p ...201524495093
a study on etiologic agents and clinical manifestations of dermatophytosis in yazd, iran.dermatophytosis is one of the most common infections of skin, hair, and nails, caused by a group of keratinophilic fungi known as dermatophytes. species identification of these fungi is of great significance from epidemiological and therapeutic points of view. the objective of the present study was to investigate dermatophytosis and its causative agents in patients, referring to the central mycology laboratory of yazd university of medical sciences, yazd, iran.201528681000
cutaneous bacterial species from lithobates catesbeianus can inhibit pathogenic dermatophytes.antibiotics are being successfully used to fight many infectious diseases caused by pathogenic microorganisms. however, new infectious diseases are continuously being identified, and some known pathogens are becoming resistant against known antibiotics. furthermore, many antifungals are causing serious side effects in long-term treatments of patients, and many skin infections caused by dermatophytes are difficult to cure. the beneficial roles of resident cutaneous microbiota to inhibit pathogeni ...201525431089
application of pcr fingerprinting using (gaca)4 primer in the rapid discrimination of dermatophytes.superficial fungal infections have a major impact on cosmetic health, affecting more than 20-25% of the global population, which is predominantly caused by dermatophytes. as per literature search, molecular strain typing of dermatophytes has not been investigated in india. therefore, the present study was carried out to characterise the dermatophyte species and strains by molecular methods.201525008813
composition and antifungal activity of zhumeria majdae essential oil.essential oils extracted from different plants are extensively used in perfume, beverage, and food industries and are reported to exhibit antimicrobial activities against a variety of fungi. zhumeria majdae belonging to the lamiaceae family is a rare and endemic medicinal plant species in iran, with a strong and pleasant odor. the leaves of this plant have been used for many years as an antiseptic carminative agent for the treatment of stomachache (especially in infants) and dysmenorrhea.201528680999
mycological pattern of dermatophytosis in and around shimla hills.dermatophytosis is defined as the fungal infection of the skin, hair and nails by a group of keratinophillic fungi known as dermatophytes.201424891658
inhibitory effect of linalool-rich essential oil from lippia alba on the peptidase and keratinase activities of dermatophytes.abstract lippia alba (miller) n.e. brown is an aromatic plant known locally as "erva-cidreira-do-campo" that has great importance in brazilian folk medicine. the aim of our study was to evaluate the antidermatophytic potential of linalool-rich essential oil (eo) from l. alba and analyze the ability of this eo to inhibit peptidase and keratinase activities, which are important virulence factors in dermatophytes. the minimum inhibitory concentrations (mics) of l. alba eo were 39, 156 and 312 µg/ml ...201423323991
characterization of a new sesquiterpene and antifungal activities of chemical constituents from dryopteris fragrans (l.) schott.one new sesquiterpene and six known compounds were isolated from dryopteris fragrans (l.) schot. they were identified as 3-o-β-d-glucopyranosylalbicanol- 11-o-β-d-glucopyranoside (1), dihydroconiferylalcohol (2), (e)-3-(4-hydroxyphenyl)acrylic acid (3), esculetin (4), 5,7-dihydroxy-2-hydroxymethylchromone (5), eriodictyol (6) and isoorientin (7) by uv, ms, 1d-nmr and 2d-nmr spectroscopy. the antifungal activities of the seven isolated compounds were screened. compounds 2, 3, 4 and 5 showed obvio ...201424451246
[taxonomic study of clinic isolates of trichophyton in rosario, argentina].due to the pleomorphism and cultural variability displayed by species of the genus trichophyton, the identification methods based solely on morphological features are usually insufficient for their classification. the goal of the present work was to test a set of phenotypic methods in order to identify fungal isolates that belong to the aforementioned genus. these methods were based on a molecular taxonomic technique used as standard. clinical isolates (56) were used as samples along with 6 refe ...201424401778
in vitro susceptibility of dermatomycoses agents to six antifungal drugs and evaluation by fractional inhibitory concentration index of combined effects of amorolfine and itraconazole in dermatophytes.to investigate the antifungal drug susceptibility of fungi responsible for dermatomycoses, minimum inhibition concentration (mic) tests were performed in 44 strains of dermatophytes, including trichophyton rubrum, trichophyton mentagrophytes, trichophyton verrucosum, trichophyton tonsurans, microsporum canis, microsporum gypseum and epidermophyton floccosum, with six antifungal drugs (amorolfine, terbinafine, butenafine, ketoconazole, itraconazole and bifonazole) by broth microdilution assay acc ...201424215461
investigation of in vitro activity of five antifungal drugs against dermatophytes species isolated from clinical samples using the e-test method.dermatomycosis is an infection with fungi related to the skin: glabrous skin, hair and/or nails. oral treatment of fungal infections in dermatology has become a preferred modality for the management of these very common conditions. although there are increasing numbers of antifungals available for treatment of dermatophytes, some cases and relapses have been unresponsive to treatment. the determination of fungus in-vitro antifungal susceptibility has been reported to be important for the ability ...201425610290
inactivation of pathogenic dermatophytes by ultraviolet irradiation in swimming pool thermal water.the effect of ultraviolet (uv) radiation from low-pressure mercury lamp against some pathogenic dermatophytes species such as epidermophyton floccosum, trichophyton mentagrophytes, trichophyton rubrum, trichophyton schoenleinii, trichophyton tonsurans and trichophyton violaceum suspended in thermal water was evaluated in laboratory-scale condition at various times. the main results showed that within 120 s of exposure, all species of dermatophytes are completely inactivated, which was evidenced ...201424024625
onychomycosis in north-east of iran.onychomycosis is a common fungal infection which has been conducted in many parts of the world. the aim of this study was to evaluate the epidemiology and to identify the aetiological factors of onychomycosis in mazandaran province, iran.201425705360
an ancient plant lawsonia inermis (henna): determination of in vitro antifungal activity against dermatophytes species.world is endowed with a rich wealth of medicinal plants. there is a widespread belief that green medicines are healthier and more harmless or safer than synthetic ones. medicinal plants have been used to cure a number of diseases. the ancient plant lawsonia inermis or henna is used as medicinal plant because of its attributed strong fungicidal, anti-inflammatory, analgesic, antibacterial, virucidal, antiparasitic, antiamoebiasis, astringent, antihemorrhagic, hypotensive, sedative, anticancer eff ...201425442917
acyclic sesquiterpenes released by candida albicans inhibit growth of dermatophytes.it is unresolved as to whether fungi that share a common skin habitat might in principal interact. in in vitro screening tests with candida albicans, trichophytum rubrum and other common dermatophytes, we found c. albicans releases volatile compounds that inhibit growth of the dermatophytes. by applying (enantioselective) gas chromatography combined with mass spectrometry we identified 8 compounds among which stereochemically pure (3r,6e)-2,3-dihydrofarnesol (r-dhf) and (2e,6e)-farnesol (f-ol) w ...201423902158
novel 1,5,7-trihydroxy-3-hydroxy methyl anthraquinone isolated from terrestrial streptomyces sp. (eri-26) with antimicrobial and molecular docking studies.streptomyces sp. isolate eri-26 was obtained from the nilgiris forest soil of western ghats, tamil nadu, india. novel anthraquinone compound was isolated from the active fraction 5; it was identified by spectroscopical data using uv, ir, nmr and mass. the isolated compound 1,5,7-trihydroxy-3-hydroxy methyl anthraquinone was tested against bacteria and fungi at minimum inhibitory concentration level. the compound showed significant antimicrobial activity against bacteria, staphylococcus aureus at ...201425149455
onychomycosis: modern diagnostic and treatment approaches.the medical term onychomycosis should be understood as chronic infection of the nails caused by a fungus. the most common causative agents are the dermatophytes and candida species. the less common are certain types of moulds (nondermatophyte moulds or ndms). in approximately 60-80 % of the cases, onychomycosis is due to dermatophytes. among dermatophytes, the most often isolated causative pathogen is trichophyton (t.) rubrum. other common species are t. interdigitale (formerly t. mentagrophytes ...201323053563
antifungal activity of phlorotannins against dermatophytes and yeasts: approaches to the mechanism of action and influence on candida albicans virulence factor.in the last few decades, fungal infections, particularly nosocomial, increased all around the world. this increment stimulated the search for new antifungal agents, especially those derived from nature. among natural products, those from marine sources have gained prominence in the last years. purified phlorotannins extracts from three brown seaweeds (cystoseira nodicaulis (withering) m. roberts, cystoseira usneoides (linnaeus) m. roberts and fucus spiralis linnaeus) were screened for their anti ...201323951297
isolation of the volatile fraction from apium graveolens l. (apiaceae) by supercritical carbon dioxide extraction and hydrodistillation: chemical composition and antifungal activity.apium graveolens l. (wild celery), belonging to the family of apiaceae, is a scaposus hemicryptophyte. instead, the cultivate plant is an annual or biennial herb widely used as a spice and seasoning in food. a broad range of biological activities have been attributed to a. graveolens. these include antimicrobial activity, larvicidal activity, hepatoprotective activity, nematicidal and mosquito repellent potential and antihyperlipidaemic properties.in this study, the authors compare the compositi ...201322974401
morphological and molecular identification of two strains of dermatophytes.in this study, we used traditional morphological and molecular identification methods to preliminarily identify two strains of dermatophytes. the two strains were observed under the microscope. and then the dermatophytes were cultured on sabouraud's dextrose agar (sda). the 18s rrna regions of the two dermatophyte strains were amplified by polymerase chain reaction (pcr), and the pcr products were sequenced and compared with genbank data. blast tools and dnaman software were used to analyze the ...201324337859
a molecular epidemiological survey of clinically important dermatophytes in iran based on specific rflp profiles of beta-tubulin gene.surveillance of dermatophytosis is essential to determine the likely changes in etiological trends and distribution profile of this infection. in this study beta tubulin gene (bt2), was used as the first time in a pcr-rflp format to clarify the distribution of dermatophytosis agents in some parts of iran.201326060667
surveillance of dermatophytosis in northeast of iran (mashhad) and review of published studies.dermatophytoses are considered to be one of the major public health problems in the world and are among the most commonly diagnosed skin diseases in iran. in spite of improved personal hygiene and living environment, dermatophytosis continues to spread and persist. to determine the prevalence of dermatophytosis and their etiologic agents in mashhad (iran), five hundred and sixty patients suspected to have fungal infection were studied. subjects who participated in this study were 330 males and 2 ...201323943426
treatment of onychomycosis using a submillisecond 1064-nm neodymium:yttrium-aluminum-garnet laser.laser treatment has emerged as a novel treatment modality for onychomycosis.201323856649
maldi-tof mass spectrometry - a rapid method for the identification of dermatophyte species.altogether 285 dermatophyte isolates of 21 different species - including both trichophyton rubrum and t. interdigitale, but also eight additional trichophyton species, microsporum canis and seven other microsporum species, as well as epidermophyton floccosum and arthroderma spp. - were analyzed using matrix assisted laser desorption ionization time-of-flight mass spectrometry (maldi-tof ms) and the anagnostec 'saramis' (spectral archiving and microbial identification system) software. in additio ...201322574631
in vitro antifungal activity of naftifine hydrochloride against dermatophytes.the incidence of superficial dermatophytoses is high in developed countries, and there remains a need for effective topical antifungals. in this study, we evaluated the in vitro antifungal activity of naftifine hydrochloride, the active ingredient in naftifine hydrochloride cream and gel 1% and 2%, against dermatophytes. the mics and minimum fungicidal concentrations (mfcs) of naftifine hydrochloride against 350 clinical strains, including trichophyton rubrum, t. mentagrophytes, t. tonsurans, ep ...201323817365
molecular analysis of dermatophytes suggests spread of infection among household members.dermatophyte infection from the same strains may be an important route for transmission of dermatophytoses within a household. in this study, we used molecular methods to identify dermatophytes in members of dermatophyte-infected households and evaluated variables associated with the spread of infection. fungal species were identified by polymerase chain reaction (pcr) using primers targeting the internal transcribed spacer (its) regions (its1 and its4). for strain differentiation, fungal dna wa ...201323772429
public health significance of dermatophytes in ismailia and port said provinces, egypt.[corrected] dermatophytes are common in both developed and developing countries, the species involved and the resulting clinical entities vary geographically.201323760076
optimization of pcr-rflp directly from the skin and nails in cases of dermatophytosis, targeting the its and the 18s ribosomal dna regions.a pan fungal primer targeting the internal transcribed spacer (its) region and optimization of pcr-rflp using a dermatophyte specific primer targeted the 18s ribosomal dna (rdna) region were performed for the identification of dermatophyte species and strains directly from clinical specimens.201323730638
evaluation of bioactivities of chlorokojic acid derivatives against dermatophytes couplet with cytotoxicity.in an attempt to find novel antifungal agents with improved activity, a series of compounds bearing 6-chloromethyl-3-hydroxy-2-substituted 4h-pyran-4-one moiety were synthesized and examined for their cytotoxic evaluation and antifungal activities against both standard and isolated dermatophytic fungal species microsporum gypseum, trichophyton mentagrophytes var. erinacei and epidermophyton floccosum.201323664872
the use of albino adult hair and blond prepubertal hair yields equivalent results in an in vitro hair perforation test to differentiate between different dermatophytic fungi.an in vitro hair perforation test is used to differentiate isolates of trichophyton mentagrophytes and trichophyton rubrum complexes because morphological criteria are insufficient. here, we performed in vitro hair perforation tests using blond prepubertal hair and albino adult hair to determine whether they differentiate between fungal species. we tested 43 well-characterized dermatophyte strains, arthroderma spp. [n = 4], epidermophyton floccosum [n = 1], microsporum spp. [n = 8], and trichoph ...201323591622
[molecular biological detection of dermatophytes in clinical samples when onychomycosis or tinea pedis is suspected. a prospective study comparing conventional dermatomycological diagnostics and polymerase chain reaction].the prevalence of onychomycosis is rising worldwide. before starting antifungal treatment, an exact mycological diagnosis should be obtained. the current laboratory diagnosis of dermatomycoses is based on the detection of the causative agent by microscopy and culture. these conventional diagnostic methods for fungal infections often are not the best solution because they are time-consuming, cultures are false-negative and direct examination identifies non-vital structures which cannot be used fo ...201323532505
in vitro antifungal activity of micafungin and caspofungin against dermatophytes isolated from china.the aims of this study are to investigate the in vitro activities of micafungin and caspofungin that are two new echinocandin antifungal drugs against clinically isolated dermatophytes in china and to define mec (minimal effective concentration) as the reading endpoints of this study in accordance with (clinical and laboratory standards institute) clsi m38-a2 reference.201322983900
molecular epidemiology of dermatophytosis in tehran, iran, a clinical and microbial survey.in the framework of a survey on dermatophytoses, 14,619 clinical specimens taken from outpatients with symptoms suggestive of tinea and referred to a medical mycology laboratory in tehran, iran, were analyzed by direct microscopy and culture. in total, 777 dermatophyte strains recovered in culture were randomly identified by a formerly established rflp analysis method based on the rdna its regions. for confirmation of species identification, 160 isolates representing the likely entire species sp ...201322587730
identification of dermatophytes by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.in this study we evaluated the suitability of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) for the identification of dermatophytes in diagnostic laboratories. first, a spectral database was built with 108 reference strains belonging to 18 species of the anamorphic genera epidermophyton, microsporum and trichophyton. all strains were well characterized by morphological criteria and its sequencing (gold standard). the dendrogram resulting from maldi-t ...201323228046
in vitro activities of antifungal drugs against dermatophytes isolated in tokat, turkey.in this study, we aimed to establish the in vitro antifungal susceptibilities of terbinafine, miconazole, itraconazole, ketoconazole, griseofulvin, and amphotericin b against dermatophyte isolates.201324134487
efficacy of some synthesized thiazoles against dermatophytes.twelve thiazoles and their fused derivatives were tested for their antimicrobial activity against trichophyton rubrum, t. terrestre, epidermophyton floccosum, and microsporum gypseum. most of the synthesized compounds were inhibitory to the tested fungi. the most effective compound was 5-(4-ethoxybenzylidene-4,5-dihydro-4-oxothiazol-2-yl)-n,3-diphenylbut-2-namide (3c) followed by 2-(4-oxo-4,5-dihydrothiazol-2-yl)-3-phenyl-but-2-enoic acid-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-amide ( ...201324129248
dermatophyte infections mimicking other skin diseases: a 154-person case survey of tinea atypica in the district of cagliari (italy).although usually simple, the diagnosis of dermatophyte infection is sometimes neglected. an observational study has been realized to evaluate the role of corticosteroid exposure (tinea incognito) and of other primary characteristics of the dermatophytosis that from onset mimic other diseases and mislead an unexperienced physician.201222435428
frequency and aetiology of dermatophytosis in children age 12 and under in the state of amazonas, brazil.few scientific studies have evaluated dermatophytosis among children in the state of amazonas or in the greater northern region of brazil.201222410497
dermatophytes isolated from the mosques in tokat, turkey.dermatophytes are a group of fungi that invade keratinized tissues such as the skin, hair and nails. the aim of this study was to investigate the existence of the potential causative agents of dermatophytosis in the mosque area in tokat, turkey. thirty mosques were included in the study. a total of two hundred samples were collected from various parts of carpets and slippers in the mosques. positive cultures were obtained in 144 samples (113 from carpets, 31 from slippers). among the species iso ...201222576940
epidemiology of dermatophytoses in crete, greece between 2004 and 2010.the present work was undertaken in order to study the epidemiology of dermatophytoses in the island of crete, greece, over a 7-year period (2004-2010) and to compare the results with those reported earlier from this region and from other parts of the world.201222648332
[2006 epidemiological survey of dermatomycoses in japan].an epidemiological survey of dermatomycoses and the causative fungus flora of dermatomycoses in japan for 2006 was made on a total number of 63,029 outpatients who visited 16 dermatological clinics throughout japan. the results were as follows. 1) dermatophytosis was the most prevalent cutaneus fungal infection (7,582 cases) seen in these clinics, followed by candidiasis (842 cases) and then malassezia infections (283 cases). 2) among dermatophytoses, tinea pedis was the most frequent (4,779 cas ...201223149353
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