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[streptococcus milleri: an unusual cause of skull extensive osteomyelitis in an immunocompetent patient].streptococcus milleri (streptococcus anginosus, intermedius and constellatus) are commensal organisms, which can become pathogenic and cause infection with frequent abscess formation, local or metastatic extension. osteomyelitis of the skull has been rarely reported in this type of infection.201728236536
late aortic silver graft re-infection due to streptococcus milleri group (streptococcus anginosus). case report and literature review. 201727883162
nas agar is more suitable than mckay agar for primary culture of streptococcus milleri group (smg) fastidious bacteria, s. intermedius in particular.streptococcus milleri group (smg) is a group of three streptococcal species (s. anginosus, intermedius and constellatus) that act as opportunist pathogens, among others in cystic fibrosis. due to their fastidious character, they are both difficult to cultivate and to differentiate from less pathogenic streptococcal species, therefore being most probably underdiagnosed. semi-selective mckay agar and nas agar were developed to facilitate smg recovery from clinical samples; however, direct comparis ...201727638003
cavernous sinus thrombosis during pregnancy.cavernous sinus thrombosis (cst) represents a rare but devastating disease process that may be associated with significant long-term patient morbidity or mortality. rapid diagnosis and aggressive medical and surgical management are imperative for patients with cst. we present the case of a 24-year-old pregnant woman with intraorbital abscess and cst secondary to streptococcus milleri. surgical intervention included orbital abscess drainage and dental extraction, medical therapy included intraven ...201727146007
in vitro/ in vivo evaluation of the efficacy of gatifloxacine-loaded plga and hydroxyapatite composite for treating osteomyelitis.molten 10 wt% gatifloxacine (glfx-loaded poly(lactide-co-glycolide) (plga) was introduced into three-dimensionally interconnected pores and onto the surfaces of hydroxyapatite (ha) granules. the composite granules exhibited clinically sufficient bactericidal activities against streptococcus milleri and bacteroides fragilis from 3 h to 10 days. the composite granules were implanted in bone defects created by debridement of osteomyelitis lesions in rabbit mandibles. after 4-week implantation, infl ...201728626206
infective endocarditis with left to right intracardiac fistula due to streptococcus anginosus - a rare complication caused by an even rarer bacterium.although infective endocarditis (ie) has been described in reports dating from the renaissance, the diagnosis still challenges and the outcome often surprises. in the course of time, diagnostic criteria have been updated and validated to reduce misdiagnosis. some risk factors and epidemiology have shown dynamic changes since degenerative valvular disease became more predominant in developed countries, and the mean age of the affected population increased. despite streptococci have been being wel ...201728584802
idiopathic pretracheal deep neck space infection with mediastinal extension: a series of 3 cases and review of the literature.idiopathic pretracheal deep neck space infection is an extremely rare condition with potentially devastating complications. we present a series of 3 cases of pretracheal deep neck space infection that arose in the absence of trauma or a congenital lesion and that exhibited mediastinal spread. to the best of our knowledge, these cases represent the first reported series of this rare condition to be published in the english-language literature. all cultures grew streptococcus milleri, and all pati ...201728636733
an update on bacterial brain abscess in immunocompetent patients.a brain abscess is a focal infection of the brain that begins as a localized area of cerebritis. in immunocompetent patients, bacteria are responsible for >95% of brain abscesses, and enter the brain either through contiguous spread following otitis, sinusitis, neurosurgery, or cranial trauma, or through haematogenous dissemination.201728501669
streptococcus milleri and recurrent intra-abdominal abscesses: a case report and literature review.we report a case of recurrent intra-abdominal abscesses as a postoperative complication following diverticular perforation in which streptococcus milleri (sm) was isolated. sm is evaluated here as a potent pyogenic organism commonly associated with intra-abdominal abscess especially in the postoperative setting. with the commonly adopted conservative management, the challenges of recurrence and prolonged hospital stay experienced in the indexed case as well as many other previous reports are hig ...201627313942
pyopneumothorax secondary to streptococcus milleri infection.we report a case of a 46-year-old malay woman with underlying hypothyroidism post thyroidectomy who presented with worsening breathlessness, orthopnoea, productive cough and left-sided pleuritic chest pain of 3 days duration. chest x-ray on admission showed left-sided massive hydropneumothorax. pleural tapping revealed empyema. a chest tube was inserted immediately. the culture of pleural fluid grew streptococcus constellatus the patient was treated with antibiotics for a total of 6 weeks and un ...201627881590
cervical necrotizing fasciitis: descriptive, retrospective analysis of 59 cases treated at a single center.to provide retrospective, descriptive information on patients with cervical necrotizing fasciitis treated at a single center during the years 1998-2014, and to evaluate the outcome of a newly introduced treatment strategy. retrospective analysis of clinical data obtained from medical records. mortality, pre-morbidity, severity of illness, primary site of infection, type of bacteria, time parameters. the observed 3-month mortality was 6/59 (10 %). the most common initial foci of the infection wer ...201627287509
the streptococcus milleri group in chronic obstructive pulmonary disease.s. anginosus, constellatus and intermedius, also known as the streptococcus milleri group (smg) are three streptococcal species more frequently detected in cases of invasive disease, abscesses and empyema in particular. recent research suggests they play a role in exacerbations of cystic fibrosis (cf). owing to poor recovery on standard culture media and difficult differentiation from non-pathogenic streptococci, smg may be underdiagnosed in routine settings. we aimed to establish the incidence ...201627132809
the sil locus in streptococcus anginosus group: interspecies competition and a hotspot of genetic diversity.the streptococcus invasion locus (sil) was first described in streptococcus pyogenes and streptococcus pneumoniae, where it has been implicated in virulence. the two-component peptide signaling system consists of the sila response regulator and silb histidine kinase along with the silcr signaling peptide and sild/e export/processing proteins. the presence of an associated bacteriocin region suggests this system may play a role in competitive interactions with other microbes. comparative analysis ...201628119678
microbiology of peritonsillar abscess in the south estonian population.the first aim of this study was to compare the microbiota of different locations (pus, tonsillar fossa, blood) in peritonsillar abscess (pta) patients in order to optimize the sampling scheme. the second aim was to estimate the occurrence of tonsillitis episodes and macroscopic oropharyngeal signs characteristic of recurrent tonsillitis in pta patients.201627113570
rare purulent cardiac tamponade caused by streptococcus constellatus in a young immunocompetent patient: case report and review of the literature.background purulent pericardial tamponade is a very rare occurrence in the current era of widespread antibiotic use. it is even rarer when caused by streptococcus constellatus: a microorganism usually classified among the normal flora of the human body. it is occasionally diagnosed with certain predisposing factors. case report we present the third case of streptococcus constellatus cardiac tamponade reported in the current medical literature, occurring in a previously healthy young man who was ...201627847383
multiple liver abscesses and bacteremia caused by streptococcus constellatus infection: a case report.the streptococcus milleri group (smg) comprises commensal mucosal bacteria. pyogenic liver abscesses due to hematogenous smg infection are rare but can be observed even in healthy patients. in such cases, physicians should consider the existence of primary lesions that allow penetration of the smg.201628096994
effects of gatifloxaine content in gatifloxacine-loaded plga and β-tricalcium phosphate composites on efficacy in treating osteomyelitis.composites of gatifloxacin (gflx)-loaded poly (lactic-co-glycolic) acid (plga) and β-tricalcium phosphate (βtcp) containing 0, 1, and 10 wt % gflx (0, 1, and 10 wt % gflx composites), and gflx-loaded plga containing 1, 5, and 10 wt % gflx (1, 5, and 10wt % gflx-plga) as controls were fabricated and characterized in vitro and in vivo. on in vitro evaluation, the 10 wt % gflx composite released gflx over at least 28 days in hanks' balanced solution and exhibited clinically sufficient bactericidal ...201625533357
in vitro volatile organic compound profiling using gc×gc-tofms to differentiate bacteria associated with lung infections: a proof-of-concept study.chronic pulmonary infections are the principal cause of morbidity and mortality in individuals with cystic fibrosis (cf). due to the polymicrobial nature of these infections, the identification of the particular bacterial species responsible is an essential step in diagnosis and treatment. current diagnostic procedures are time-consuming, and can also be expensive, invasive and unpleasant in the absence of spontaneously expectorated sputum. the development of a rapid, non-invasive methodology ca ...201627120170
microbiology and choice of antimicrobial therapy for acute sinusitis complicated by subperiosteal abscess in children.review past studies of the microbiology of subperiosteal abscesses (spoa) complicating sinusitis in children and their implications of the antimicrobials administered to treat the infection.201627063747
peritoneal fluid culture and antibiotic treatment in patients with perforated appendicitis in a pacific island.little data on the usefulness of microbiological samples in appendicular peritonitis (ap) are available. the objectives of the study were to document the clinical value of systematic peritoneal swabbing in complicated appendicitis, to establish whether they influence postoperative outcome, and to help to optimize empirical preoperative treatment.201525944107
prevalence of opportunistic infections in hiv-positive patients in bahrain: a four-year review (2009-2013).this study aimed to examine the prevalence of opportunistic infections in hiv-infected patients in bahrain and its relation to absolute cd4 count, cd4%, and cd4/cd8 ratio.201525596573
streptococcus constellatus causing septic thrombophlebitis of the right ovarian vein with extension into the inferior vena cava.introduction. streptococcus constellatus collectively with streptococcus anginosus and streptococcus intermedius constitute the streptococcus anginosus (formerly streptococcus milleri) group. though they are commonly associated with abscesses, bacteremia with subsequent septic thrombophlebitis is extremely rare, and resulting mortality is infrequent. case presentation. we report a case of a previously healthy 60-year-old african american female who presented with streptococcus constellatus bacte ...201526171262
pylephlebitis after colonic polypectomy causing fever and abdominal pain.pylephlebitis is a rare condition with a high mortality risk if not recognized and treated early. the most common symptoms include fever and abdominal pain, with the majority of cases manifesting with a polymicrobial bacteremia. we report an elderly woman with pylephlebitis presenting with fever, abdominal pain, diarrhea, and vomiting, likely secondary to a polypectomy 6 weeks prior. abdominal ct revealed portal vein thrombus and blood cultures grew streptococcus milleri and haemophilus parainfl ...201526157944
microbial flora and antibiotic resistance in peritonsillar abscesses in upstate new york.to identify the common bacteria in recent peritonsillar abscesses and the prevalence of antibiotic resistance and compare both between adults and children.201526023143
management and outcomes in children with sinogenic intracranial abscesses.to report our experience of sinogenic intracranial abscesses in the paediatric population and to guide medical and surgical management.201525887135
prosthetic aortic valve: a bone in the system.we report a case of a 73-year-old female patient admitted to the surgical department for a splenic abscess. she had a history of a mechanical aortic valve implanted two years earlier. during the diagnostic work-up, the patient underwent a transesophageal echocardiogram that revealed the presence of multiple paravalvular abscesses, establishing the diagnosis of prosthetic valve endocarditis. a few days later, the echocardiogram was repeated due to a new-onset systolic-diastolic murmur. a large ps ...201525660459
parafalcine empyema, a tricky infectious cause of headache: a case report.headache caused by subdural empyema is usually associated with fever and symptoms and/or clinical signs of meningeal irritation and increased intracranial pressure. we describe a patient with headache with absence of these signs or symptoms of meningeal irritation or intracranial pressure, who turned out to have a parafalcine subduralempyema. a 28-year-old man had headache for 2 weeks, which had started with visual symptoms with duration of 5 minutes. two days later, he developed fever. during t ...201525618767
extensive thoracolumbosacral vertebral osteomyelitis after lemierre syndrome.to present a unique case of multilevel vertebral osteomyelitis after lemierre syndrome.201525245891
host cytokine responses distinguish invasive from airway isolates of the streptococcus milleri/anginosis group.the streptococcus milleri/anginosus group (smg) colonize mucosal surfaces, especially the airways, and are considered to be normal mucosal microbiota; however, they are a major cause of abscesses, pneumonia and pleural empyema. the production of exoenzymes and virulence factors do not correlate with smg pathogenicity. since smg infections are associated with robust inflammatory responses, we hypothesized that host immune responses might distinguish strains associated with asymptomatic carriage a ...201425209732
purulent pericarditis after transbronchial biopsy.a 28-year-old woman experienced hypotension and unresponsiveness. she had undergone bronchoscopy with needle biopsy 2 weeks before admission to evaluate hilar lymphadenopathy given suspicion of sarcoidosis. she had an elevated white blood cell count of 28,000/μl and a serum creatinine level of 4.0 mg/dl. echocardiography showed a large pericardial effusion. pericardiocentesis resulted in removal of 400 ml of yellow-green purulent material that grew streptococcus milleri, prevotella, veillonella, ...201425138484
rhinosinusitis in children: a comparison of patients requiring surgery for acute complications versus chronic disease.patient characteristics, risk factors, and microbiology are important to consider in the management of complications of acute bacterial sinusitis (abs) in pediatric patients. this study evaluates this subset of patients and compares them to patients that undergo surgery for chronic rhinosinusitis (crs).201425069389
silent diabetes mellitus, periodontitis and a new case of thalamic abscess.brain abscess is an unusual complication of uncontrolled diabetes. a solitary thalamic abscess is an uncommon type of brain abscess. we report a case of thalamic abscess, whereupon diabetes mellitus and periodontitis were diagnosed. the diagnosis and management of thalamic abscess, and the interplay of type 2 diabetes and periodontitis are discussed. a 56-year-old, caucasian, man with no medical or travel history, presented with 5-day symptoms of meningeal irritation. body mass index 30.6 kg/m(2 ...201425053670
a retrospective study on the aetiology, management, and outcome of brain abscess in an 11-year, single-centre study from china.brain abscesses continue to pose diagnostic and therapeutic challenges in developed and developing countries. their aetiology and management remain complex and unclear, making improvement of treatments and outcome difficult.201424903315
multiorgan streptococcus milleri abscesses during folfirinox chemotherapy in a patient with metastatic pancreatic cancer. 201425276270
streptococcus constellatus community acquired pneumonia with subsequent isolated pulmonic valve endocarditis and abscess formation in a structurally normal heart.pulmonic valve infective endocarditis in isolation is a rare clinical entity. the formation of an abscess in the right ventricular outflow tract as a consequence of vegetations affecting the pulmonic valve in a structurally normal heart is extremely rare and has not been reported. we report a case of isolated pulmonic valve endocarditis complicated by a regional abscess formed within the right ventricular outflow tract caused by streptococcus constellatus (s. constellatus), a member of the strep ...201425031801
molecular pathogenicity of streptococcus anginosus.streptococcus anginosus and the closely related species streptococcus constellatus and streptococcus intermedius, are primarily commensals of the mucosa. the true pathogenic potential of this group has been under-recognized for a long time because of difficulties in correct species identification as well as the commensal nature of these species. in recent years, streptococci of the s. anginosus group have been increasingly found as relevant microbial pathogens in abscesses and blood cultures and ...201424848553
emerging cystic fibrosis pathogens and the microbiome.cystic fibrosis (cf) respiratory infection is characterised by the presence of typical human bacterial pathogens such as pseudomonas aeruginosa, haemophilus influenzae and staphylococcus aureus. less typical pathogens such as burkholderia, stenotrophomonas, achromobacter, pandorea and ralstonia have emerged as problematic infections which are largely unique to people with cf. using molecular methods, two groups of anaerobic bacteria prevotella species and the streptococcus milleri group have als ...201424832700
pleural effusion due to streptococcus milleri: case descriptions.in this study we analyzed the characteristics of patients with pleural effusion secondary to streptococcus milleri studied retrospectively between january and march 2013 and found seven patients with a mean age of 60 years, 43% of which were smokers and 57% with a drinking habit. the most common associated factors were alcoholism, previous pneumonia and diabetes. other bacteria were identified as enterobacter aerogenes, bacteroides and prevotella intermedia capillosus in two patients. the mean d ...201424439468
the increasing incidence of empyema.the aim of this review is to highlight recent changes concerning the incidence of empyema. in this article we have focused on community-acquired empyema201323508113
clinical and microbiologic features guiding treatment recommendations for brain abscesses in children.there are no guidelines for the management of brain abscesses in children, and there is a paucity of recent data describing clinical and microbiologic features. we aimed to identify factors affecting outcome to inform antibiotic recommendations.201323001027
lincosamide resistance mediated by lnu(c) (l phenotype) in a streptococcus anginosus clinical isolate.unique resistance to lincosamides (l phenotype) due to the production of nucleotidyltransferases (lnu) is uncommon among gram-positive bacteria. the aim of the study was to characterize the l phenotype in a clinical isolate of the streptococcus milleri group.201323812683
the predominant bacteria isolated from radicular cysts.to detect predominant bacteria associated with radicular cysts and discuss in light of the literature.201324011184
streptococcus anginosus pyogenic liver abscess following a screening colonoscopy.a previously healthy 58-year-old man presented with a septic thrombosis of the right hepatic vein and a pyogenic liver abscess (pla) one week after undergoing a screening colonoscopy. blood cultures and a radiological drainage specimen were both positive for streptococcus anginosus. evolution was favourable after six weeks of antibiotherapy. to the authors' knowledge, the present report is the first to describe a pla following a screening colonoscopy with no intervention. the authors hypothesize ...201324421818
identification of β-haemolysin-encoding genes in streptococcus anginosus.streptococcus anginosus is an emerging pathogen, but little is known about its virulence factors. to detect the genes responsible for β-haemolysis we performed genomic mutagenesis of the β-haemolytic s. anginosus type strain atcc 12395 using the vector pghost9:iss1. integration site analysis of 15 non-haemolytic mutants identified a gene cluster with high homology to the genes of the streptolysin s (sls) encoding sag gene cluster of s. pyogenes. the gene cluster harbours 10 open reading frames d ...201323594064
[streptococcus intermedius: a rare cause of brain abscess in children].streptococcus intermedius is a member of the streptococcus anginosus group, also known as the streptococcus milleri group. although this is a commensal agent of the mouth and upper airways, it has been recognized as an important pathogen in the formation of abscesses. however, it has rarely been involved in the formation of brain abscess in children. we report 4 pediatric cases of brain abscess caused by s. intermedius. three boys and 1 girl, all aged over 2 years, were admitted for a febrile me ...201323375710
a case of spontaneous abscess of the corpus cavernosum.spontaneous abscess of the corpus cavernosum is an extremely rare presentation. this is the first documented case of corpus cavernosal abscess caused exclusively by organisms from the streptococcus milleri group, which have previously been described as being associated with abscess formation. this report outlines the case of a 56-year-old alcoholic male with no risk factors who presented with an 8-day history of penile pain, swelling and sepsis. a diagnosis of abscess of the right corpus caverno ...201323506057
comparative analysis of colony counts of different species of oral streptococci in saliva of dentulous, edentulous and in those wearing partial and complete dentures.to study and compare the number of colony forming units of streptococcus mutans, streptococcus sanguis, streptococcus salivarius, streptococcus mitis and streptococcus milleri in dentulous, edentulous and in those wearing partial and complete dentures by using semi-quantitative culture method of saliva samples with calibrated standard loop.201324309335
brain abscess after transanal hemorrhoidal dearterialization: a case report.a relatively new therapy in the treatment of hemorrhoids is transanal hemorrhoidal dearterialization (thd). we report a case of brain abscess caused by streptococcus milleri following thd. although a brain abscess after drainage of a perianal abscess has been described in the literature, no report exists of a brain abscess following treatment of hemorrhoids. a healthy 51-year-old man with hemorrhoids underwent thd. two weeks later he presented with a headache, bradyphrenia, flattened behavior an ...201323741208
a liver abscess presenting as bowel obstruction and perforation.a 69-year-old cachexic man presented with tachycardia and hypotension on a background of 7 days of vomiting and constipation. he was not obviously in pain. he had a raised white cell count of 24.8×10(9)/l, and a lactate of 2.2 mmol/l. a chest x-ray had the appearance of free air under the diaphragm and he was suspected of having a bowel obstruction with perforation. an abdominal ct scan showed instead a large fluid and gas-filled hepatic abscess, and a second smaller simple cyst. the abscess was ...201323608874
high-resolution ct findings in streptococcus milleri pulmonary infection.to assess pulmonary high-resolution computed tomography (ct) findings in patients with acute streptococcus milleri pulmonary infection.201323518496
empyema and psoas abscess in a previously undiagnosed diabetic patient.a 48-year-old man presented with a 2-month history of polyuria, polydypsia, chest pain, fever, cough and extreme weight loss. he was diagnosed with diabetic ketoacidosis and investigations revealed widespread infection with an empyema complicated by bronchopleural fistula, and iliopsoas, suprapubic and periarticular abscesses. streptococcus milleri was cultured from all sites. a multidisciplinary medical and surgical approach was required for treatment. this case highlights the immunosuppression ...201323463114
intramedullary abscess of the upper cervical spinal cord. unusual presentation and dilemmas of management: case report. 201323453154
early diagnosis and treatment of necrotizing fasciitis can improve survival: an observational intensive care unit cohort study.the aim of this study was to describe the clinical characteristics, causative pathogens, clinical management and outcomes of patients presenting to a tertiary adult australian intensive care unit (icu) with a diagnosis of necrotizing fasciitis (nf).201322989238
is there any difference in pyogenic liver abscess caused by streptococcus milleri and klebsiella spp?: retrospective analysis over a 10-year period in a regional hospital.to compare the clinical characteristics of patients with streptococcus milleri (sm) and klebsiella spp. associated pyogenic liver abscess (pla).201322578643
mycotic pseudoaneurysm of the aortic arch with purulent pericardial effusion.a 67-year-old woman presented with dyspnea on exertion and a diminished left radial pulse in comparison with the right. she had signs and symptoms of cardiac tamponade. a computed tomographic (ct) angiogram of the chest revealed an aortic arch pseudoaneurysm along the lesser curvature and a large pericardial effusion with the density of blood. upon pericardiotomy, a nonhemorrhagic thick purulent effusion (streptococcus milleri) was discovered in the pericardial space. replacement of the aortic a ...201222450083
[pott's puffy tumor--a rare complication of frontal sinusitis].pott's puffy tumor is an extremely rare complication of frontal sinusitis. it is most typically found in young men. streptococci, staphylococci or anaerobic bacteria are usually the causative agents. in our patients the inflammation was caused by streptococcus milleri and streptococcus pneumoniae. the treatment should be started with broad-spectrum antibiotics. the antibiotics are administered intravenously for 1 to 2 weeks and thereafter orally for at least four weeks. paranasal sinuses must be ...201222312832
[diffuse cervical cellulitis and descending mediastinitis].the principal objective is to evaluate the circumstances of diagnosis and the treatment of cervical cellulitis and descending mediastinitis.201224006825
septic thrombosis of the cavernous sinus secondary to a streptococcus milleri oral infection.septic thrombosis of the cavernous sinus (stcs) is an uncommon and potentially lethal disease. sphenoid and ethmoid sinusitis followed by facial cutaneous infections represents the most common aetiologies, with staphylococcus aureus as the main responsible organism followed by the streptococcus pneumoniae. although all infectious foci of the head and neck area can potentially spread to the cavernous sinus, stcs from oral infection is an exceptionally rare occurrence. we report the unusual case o ...201222241881
the cystic fibrosis airway microbiome.culture and molecular approaches have established that lower airway infections are polymicrobial. we consider how this new perspective in cystic fibrosis (cf) may affect treatment choices.201222965275
streptococcus milleri head and neck abscesses: a case series.streptococcus milleri infections and abscesses in the head and neck region have been previously reported, but there is still a dearth of clinical literature on this topic. to add to the available reports and to promote a better understanding and awareness of this clinically important entity, we present this retrospective review of 7 cases of head and neck abscess caused by s milleri infection. we have placed particular emphasis on antibiotic sensitivity patterns. these patients-6 men and 1 woman ...201222711392
[purulent pericardial tamponade secondary to hepatic abscess caused by streptococcus milleri]. 201222613196
streptococcus milleri in intraabdominal abscesses in children after appendectomy: incidence and course.intraabdominal abscesses are a common complication after appendectomy, especially in children. in this study, we describe the incidence and course of this complication in relation to the cultured pathogens found in intraabdominal abscesses.201222424350
inflammatory index and treatment of brain abscess.this study retrospectively analyzed 12 patients with brain abscesses. half of the patients were diagnosed inaccurately in the initial stage, and 7.2 days were required to achieve the final diagnosis of brain abscess. the patients presented only with a moderately elevated leukocyte count, serum crp levels, or body temperatures during the initial stage. these markers changed, first with an increase in the leukocyte count, followed by the crp and body temperature. the degree of elevation tended to ...201223092104
the most common isolates from pleural infections.isolation and identification of the pathogens are important for appropriate treatment of pleural infections. distribution of the most frequent causative agents varies throughout the world and may change in time.the objective of the study is to analyze the bacteriological isolates of pleural fluids in order to identify the most frequent infectious agents and assess their variability in time.the retrospective study included 272 patients with positive pleural fluid samples analyzed in 5-year period ...201222982641
prevalence of streptococci and increased polymicrobial diversity associated with cystic fibrosis patient stability.diverse microbial communities chronically colonize the lungs of cystic fibrosis patients. pyrosequencing of amplicons for hypervariable regions in the 16s rrna gene generated taxonomic profiles of bacterial communities for sputum genomic dna samples from 22 patients during a state of clinical stability (outpatients) and 13 patients during acute exacerbation (inpatients). we employed quantitative pcr (qpcr) to confirm the detection of pseudomonas aeruginosa and streptococcus by the pyrosequencing ...201222753064
an analysis of clinical risk factors of deep neck infection.to clarify the clinical risk factors that aggravate deep neck infection.201120609540
bacteriologic epidemiology and empirical treatment of pediatric complicated appendicitis.preoperative samples in the context of complicated appendicitis (ca) are rarely collected, and there is no consensus regarding the optimal antibiotic therapy in children. to help optimize empirical preoperative treatment, we studied clinical and bacteriologic data from a prospective cohort of 93 children with ca in a french hospital. all the bacteria isolated from peritoneal fluids were identified, using phenotypic and/or molecular techniques. the most commonly recovered species were escherichia ...201121396532
pyogenic liver abscess: an audit of 10 years' experience.to describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy.201121472130
orbital dissemination of lemierre syndrome from gram-positive septic emboli.a 45-year-old patient presented with bilateral orbital abscesses. he was found to have lemierre syndrome, a condition involving septic thrombophlebitis of the internal jugular vein. the patient developed severe proptosis, sepsis, and cavernous sinus thrombosis. despite aggressive antibiotic and anticoagulation therapy, visual loss was rapid, and the patient ultimately died. lemierre syndrome, previously thought to be rare, is now becoming more commonly reported. its prompt diagnosis and treatmen ...201121566465
not just a 'simple stroke'.a 51-year-old man presenting with left arm weakness and slurred speech was referred to the acute medical team. admission chest x-ray showed a cavitating lesion, which had not been present 2 weeks earlier. systemic enquiry elicited a 2 month prodromal illness and back pain. urgent ct of his head and chest revealed evidence of thoracic discitis spreading anteriorly into a pleural-based lung abscess and an intracerebral abscess causing his neurological deficit. he was transferred for urgent craniot ...201121573264
gatifloxacine-loaded plga and β-tricalcium phosphate composite for treating osteomyelitis.gatifloxacine (gflx)-containing poly(lactide-co-glycolide) (plga) was introduced to the pores and surfaces of porous β-tricalcium phosphate (βtcp) granules by melt compounding whereby no toxic solvent was used. the granular composite of gflx-loaded plga and βtcp released gflx for 42 days in hanks' balanced solution and exhibited sufficient in vitro bactericidal activity against streptococcus milleri and bacteroides fragilis for at least 21 days. for in vivo evaluation, the granular composite was ...201121597226
bacteriology of deep neck abscesses: a retrospective review of 96 consecutive cases.introduction: this study aimed to review the microbiology of deep neck abscesses and identify the factors that influence their occurrence. methods: a retrospective chart review was done of patients diagnosed with deep neck abscesses at the department of otorhinolaryngology, tan tock seng hospital, singapore between 2004 and 2009. the data of 131 deep neck abscess patients were reviewed, and those with positive pus culture were included in the study. logistic regression was applied to analyse and ...201121633769
lung abscesses: a case study of group f. streptococci.[no abstract].201121682988
Streptococcus milleri in hand infections. 201121816892
Re: "Orbital dissemination of Lemierre syndrome from gram-positive septic emboli". 201122072204
microbiology of acute complicated bacterial sinusitis at the university of the witwatersrand.a retrospective chart review study at two referral hospitals identified 226 consecutive surgical patients with acute complicated sinusitis.201020822623
streptococcus milleri group pleuropulmonary infection in children: computed tomographic findings and clinical features.streptococcus milleri group streptococci have recently been increasingly recognized as important pulmonary pathogens, but their imaging features have not been well documented in children. we have recently observed a number of cases of this infection among pediatric patients at our tertiary care, children's hospital. our purpose was to investigate the computed tomographic (ct) findings and clinical features of s. milleri group pleuropulmonary infection in children.201021084911
precipitating factors in the pathogenesis of peritonsillar abscess and bacteriological significance of the streptococcus milleri group.peritonsillar abscess (pta) is conventionally considered to be a complication of acute tonsillitis, but no pathogenical association has been demonstrated. to investigate the precipitating factors in the pathogenesis of pta, the clinical status of 117 patients with pta and 78 patients with peritonsillar cellulitis (pc) were reviewed, comparing them with 188 cases of acute tonsillitis as a control group. the period between the onset of symptoms and the date of starting hospitalized medication was ...201021086007
[bacterial meningitis secondary to spinal analgesia and anaesthesia].although rare, infectious complications from spinal analgesia and anaesthesia (sa) can have serious morbidity and mortality. this study describes the clinical features and outcome of sa-associated bacterial meningitis in adults seen in a hospital over a 25 yearperiod.201021093704
molecular characterization and phylogenetic analysis of quinolone resistance-determining regions (qrdrs) of gyra, gyrb, parc and pare gene loci in viridans group streptococci isolated from adult patients with cystic fibrosis.ciprofloxacin is the most frequently used member of the fluoroquinolones during initial eradication therapy of pseudomonas aeruginosa, as well as during acute pulmonary exacerbations. however, its long-term effect on the susceptibility of the commensal flora within the cystic fibrosis (cf) airways has not yet been examined. the aim of this study was therefore to examine the consequence of oral ciprofloxacin usage on the resistance of the commensal viridans group streptococci (vgs), in terms of m ...201021193474
[recurrent liver abscesses]. 201021352728
an algorithm for early diagnosis of cervicofacial necrotising fasciitis.cervicofacial necrotising fasciitis (cnf) is a potentially fatal infection which can occasionally present in the head and neck. an early diagnosis and aggressive treatment is imperative for minimising the associated mortality and morbidity. the early clinical features are usually non-specific which makes it difficult to differentiate it from other less serious infections. necrosis of the skin is a late feature. although it is more common in the immunocompromised, it can also affect normal indivi ...201020396897
macrolide and clindamycin resistance in streptococcus milleri group isolates from the airways of cystic fibrosis patients.organisms belonging to the streptococcus milleri group (smg) are known for their role in pyogenic infections but have recently been implicated as etiological agents of pulmonary exacerbation in adult patients with cystic fibrosis (cf). the prolonged exposure of cf patients to antibiotics prompted us to investigate the susceptibility profiles of 118 smg isolates from the airways of cf patients to 12 antibiotics compared to 43 smg isolates from patients with invasive infections. we found that appr ...201020404127
microbiology in complicated head and neck infections.to identify the pathogens associated with complicated ear, throat and sinus infections and to link the relevant susceptibility patterns to the empirical therapy currently advised in the dutch guidelines.201020420077
the streptococcus milleri population of a cystic fibrosis clinic reveals patient specificity and intraspecies diversity.the genetic relatedness of streptococcus milleri group isolates from the airways of cystic fibrosis patients was determined by using pulsed-field gel electrophoresis. this study reveals no evidence for patient-to-patient transmission in our patient population; however, within individual patients, complex inter- and intraspecies diversity and dynamics can be observed.201020463160
[a girl with a swelling on her forehead].a 9-year-old girl presented with headache and swelling of her forehead caused by a pott's puffy tumour.201020482928
68-year-old man with chronic cough and weight loss. 201020511475
abdominal abscesses with streptococcus milleri group after laparoscopic chromopertubation. 201020515429
microbiology of odontogenic infections in deep neck spaces: a retrospective study.the primary treatment of deep neck spaces odontogenic infection (dnsoi) with suppuration is surgery. systemic antimicrobial therapy is an important adjunct. the initial prescription of antimicrobial therapy is empirical. over the last decade we have observed a change in practice with the use of second-generation cephalosporins, in conjunction with metronidazole, replacing benzylpencillin and metronidazole. more recently evidence has emerged suggesting that antimicrobial resistance in nosocomial ...201019178989
group milleri streptococci in perianal infections.anal abscesses are commonly associated with fistulas-in-ano and are usually polymicrobial in nature, with gram-negative rods and anaerobes being the most prevalent isolates. group milleri streptococci (gms) comprise a heterogeneous group of cocci, which are capable of causing severe purulent infection with a high recurrence rate.201019341401
streptococcus anginosus (streptococcus milleri group) pyomyositis in a 50-year-old man with acquired immunodeficiency syndrome: case report and review of literature.we describe the first reported case of bacterial pyomyositis of the right thigh caused by streptococcus anginosus (s. milleri group) in an hiv-infected patient. the clinical presentation was complicated by multiple ring-enhancing lesions detected on magnetic resonance imaging of the brain. evaluation for central nervous system toxoplasmosis,syphilis, and cryptococcal infection was negative. aggressive antibiotic therapy directed against s. anginosus and surgical debridement were limb salvaging. ...201019904493
characterization of streptococcus milleri group isolates from expectorated sputum of adult patients with cystic fibrosis.with the recent insights into the streptococcus milleri group (smg) as pulmonary pathogens in patients with cystic fibrosis (cf), we sought to characterize 128 isolates from the sputum of adults with cf, along with 45 isolates from patients with invasive diseases for comparison. the tests performed included lancefield grouping; tests for hemolysis; tests for the production of hyaluronidase, chondroitin sulfatase, dnase, proteases, and hydrogen peroxide; and pcr for the detection of the intermedi ...201020007382
necrotizing fasciitis of the chest wall.necrotizing fasciitis (nf) is an uncommon infection caused by microorganisms called 'flesh eating bacteria'. it remains a life-threatening condition associated with high mortality rate. its location to the chest wall is exceptional. herein, we report the case of a 39-year-old female, without comorbidity, presenting a nf of the chest wall complicating an empyema. we describe the surgical management with a three-step procedure: antibiotherapy-debridement, vacuum-assisted closure and delayed surgic ...201020019031
necrotizing fasciitis following drainage of streptococcus milleri empyema.streptococcus milleri (sm) is a heterogeneous group of streptococci, which is a recognized cause of purulent infections of the mediastinal and pleural spaces. these infections are notoriously resistant and require aggressive surgical management. we present our experience with a 60-year-old patient, who developed necrotizing fasciitis of the chest wall after initial bedside drainage of a sm empyema. he required extensive debridement with significant soft tissue loss and subsequent latissimus dors ...201020026487
pyothorax resulting from peritonsillar abscess. 201020089022
development of real-time pcr assays for detection of the streptococcus milleri group from cystic fibrosis clinical specimens by targeting the cpn60 and 16s rrna genes.cystic fibrosis (cf) is a multiorgan disease, with the majority of mortalities resulting from pulmonary failure due to repeated pulmonary exacerbations. recently, members of the streptococcus anginosus group (s. anginosus, s. constellatus, and s. intermedius), herein referred to as the "streptococcus milleri group" (smg) have been implicated as important etiological pathogens contributing to pulmonary exacerbations in cf patients. this is partly due to better microbiological detection of the smg ...201020164275
antibacterial effect of silver-zeolite containing root-canal filling material.the aim of this study was to determine the in vitro antibacterial effect of two experimental glass ionomer cements (gics) on streptococcus milleri, staphylococcus aureus, and enterococcus faecalis after 24 and 48 h incubation by using the agar diffusion inhibitory test. silver zeolite (sz) was added at 0.2 and 2% mass fraction concentration to gic (endion). the control group was endion with no sz. each of them were prepared to uniform size using a custom-made teflon mold, and the gic materials w ...200919165767
contribution towards developing a new semi-selective medium for streptococcus anginosus group.the aim of this study was to develop a new selective medium for isolation of streptococcus anginosus group (sag) strains, by adding sulphamethazine and aztreonam as selective agents at mitis-salivarius agar (msa), the medium commonly used for recovery of oral streptococci from oral samples. material and method: the evaluation of mitis-salivarius--sulphamethazine--aztreonam agar (mssaa) for sag selectivity was performed by testing the growth of type strains and laboratory-stored clinical isolates ...200920191907
effect of a single-use toothbrush on plaque microflora.to study and compare the microbial flora of dental plaque after the use of a self-contaminated toothbrush and that of a single-use toothbrush.200920139560
enterovascular fistula in a patient with squamous cell carcinoma arising in a cystic teratoma. 200919373163
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