Publications

TitleAbstractYear(sorted descending)
Filter
PMID
Filter
"identification of virulent capnocytophaga canimorsus isolates by capsular typing".capnocytophaga canimorsus is a dog oral commensal that causes rare but severe infections in humans. c. canimorsus was recently shown to be endowed with a capsular polysaccharide implicated in the resistance to the innate immune system of the host. here we developed the first c. canimorsus capsular serotyping scheme. we describe nine different serovars (a to i), which allowed to type 25/25 isolates from human infections but only 18/52 isolates from dog mouths, indicating that the repertoire of ca ...201728381610
fatal infection caused by capnocytophaga canimorsus. 201728134123
capnocytophaga canimorsus, a rare cause of bacterial meningitis. 201728034443
inactivation of human coagulation factor x by a protease of the pathogen capnocytophaga canimorsus.essentials capnocytophaga canimorsus causes severe dog bite related blood stream infections. we investigated if c. canimorsus contributes to bleeding abnormalities during infection. the c. canimorsus protease ccdpp7 causes factor x dysfunction by n-terminal cleavage. ccdpp7 inhibits coagulation in vivo, which could promote immune evasion and trigger hemorrhage.201728029716
[dyspnea and skin rash in a 49-year-old male patient].we report on the case of a 49-year-old man who presented with increasing dyspnea and a skin rash. the community-acquired pneumonia was initially treated with broad spectrum antibiotics. the patient's respiratory condition rapidly worsened and the clinical picture of waterhouse-friderichsen syndrome developed with disseminated intravasal coagulopathy and necrosis of the toes. an infection with capnocytophaga canimorsus, which had been caused by an initially unmentioned dog bite was confirmed. in ...201727900398
capnocytophaga canimorsus – an underestimated danger after dog or cat bite – review of literaturecapnocytophaga canimorsus is a gram-negative, capnophilic rod constituting normal bacterial flora of the oral cavity of dogs and cats. it is also considered to be an etiological factor of infections in human that may lead to multiple complications, i.a. sepsis, endocarditis and meningitis. c. canimorsus poses a serious threat, especially to patients with asplenia, cirrhosis or alcohol abuse. in most cases, infection occurs after a dog bite. isolation and identification of the bacteria from the b ...201727837588
atypical hemolytic uremic syndrome associated with capnocytophaga canimorsus. 201727580961
capnocytophaga canimorsus sepsis in a methotrexate-treated patient with rheumatoid arthritis.capnocytophaga canimorsus is a gram-negative rod that can be transmitted primarily by dog bites. this life-threatening organism commonly causes sepsis in patients with splenectomy or alcoholism. a 53-year-old rheumatoid arthritis male treated with methotrexate (mtx) for 5 years was admitted for a 4-day history of fever and dyspnea. he had been bitten on a finger by the family dog 4 days before onset. laboratory tests revealed pancytopenia, acute renal failure, and evidence of disseminated intrav ...201728831382
cave canem: hbo₂ therapy efficacy on capnocytophaga canimorsus infections: a case series.dog bites are a frequent injury, but the incidence and type of lesions vary across countries. although only few patients develop complications, the treatment of advanced injuries has a considerable medical, social and economic impact. a frequently isolated pathogen in dog bite wounds is capnocytophaga canimorsus, a bacterium that can cause sepsis or meningitis. hyperbaric oxygen (hbo₂) therapy has been shown to be useful in treating anaerobic infections, most likely because it creates an inhospi ...201728777909
[capnocytophaga canimorsus: a cause of multi-organ failure accompanied by livedo]. 201728549666
capnocytophaga canimorsus - an underestimated cause of periprosthetic joint infection?periprosthetic joint infection (pji) is a major clinical problem in orthopedic surgery. capnocytophaga canimorsus (c. canimorsus) is an unusual and hardly detectable bacterium. a review of the literature indicates that c. canimorsus affects mainly immunocompromised patients. it has not been reported to cause periprosthetic joint infections in immunocompetent patients so far. this case report aims to raise awareness of c. canimorsus in orthopedic surgery with special regard to joint arthroplasty.201728526202
  201728443707
a small 'lick' will sink a great ship: fulminant septicaemia after dog saliva wound treatment in an asplenic patient.capnocytophaga canimorsus is a bacterium transmitted through the saliva of dogs. an infection can cause severe sepsis with acral necrosis and is potentially fatal. here, we report the case of a 41-year-old man who was infected through a wound that was licked by his dog. he went into septic shock with disseminated intravascular coagulation and subsequently lost both lower legs, his nose and all the fingers on both hands.201728425162
lick of death: capnocytophaga canimorsus is an important cause of sepsis in the elderly.a 70-year-old caucasian woman was treated for capnocytophaga canimorsus septicaemia. the source of bacteraemia was very likely to be her household pet, an italian greyhound. the patient presented with a presumed complex partial seizure but deteriorated rapidly with sepsis and multiorgan dysfunction. neither scratch nor bite was established, although close petting including licks was reported. blood cultures grew gram-negative rods, identified by molecular techniques as c. canimorsus-a bacterium ...201627364692
capnocytophaga canimorsus bacteremia: clinical features and outcomes from a helsinki icu cohort.capnocytophaga canimorsus is a gram-negative rod capable of causing severe sepsis or septic shock. we studied the characteristics of patients with c. canimorsus bacteremia treated in intensive care unit (icu).201627251795
urticarial exanthem associated with capnocytophaga canimorsus bacteremia after a dog bite. 201627051842
mycotic aneurysm following a dog bite: the value of the clinical history and molecular diagnostics.a 63-year-old caucasian taxi driver presented with a 3-week history of malaise, night sweats, 7 kg weight loss, generalized arthralgia, and persistent mid-lower abdominal pain. blood inflammatory markers were raised, and a computed tomography scan demonstrated an irregular degeneration of the infrarenal aorta, with a differential diagnosis including aortic infection. an urgent type iv thoracoabdominal aneurysm repair was performed with a rifampicin-soaked aortic tube graft during an open procedu ...201626802291
capnocytophaga canimorsus sepsis following a minor dog bite to the finger: case report.capnocytophaga canimorsus is a gram-negative bacillus present in the oral cavities of 22% to 74% of healthy dogs. capnocytophaga canimorsus has unique virulence factors that enable it to evade the human immune system and cause life-threatening sepsis following a dog bite. we report a previously well 68-year-old woman who presented with septic shock and multiorgan failure following a seemingly minor dog bite to the finger. the patient required intensive care treatment, intravenous antibiotic ther ...201626710739
capnocytophaga canimorsus meningitis: three cases and a review of the literature.bacterial meningitis is a disease with a high morbidity and mortality. it may be caused by the zoonotic pathogen capnocytophaga canimorsus, which is part of the commensal oral flora in dogs and cats. we report three cases of c. canimorsus meningitis in a nationwide cohort study of bacterial meningitis patients and performed a review of the literature. three episodes of c. canimorsus meningitis were identified in three patients included in a nationwide cohort study from 2006 through 2014. the cal ...201626693951
diagnosis of capnocytophaga canimorsus sepsis by whole-genome next-generation sequencing.we report the case of a 60-year-old man with septic shock due to capnocytophaga canimorsus that was diagnosed in 24 hours by a novel whole-genome next-generation sequencing assay. this technology shows great promise in identifying fastidious pathogens, and, if validated, it has profound implications for infectious disease diagnosis.201627704003
[pets are a risk for asplenic patients: capnocytophaga canimorsus infection in an asplenic patient].post-splenectomy sepsis is a serious condition with high mortality rates. we present a case of a 64-year-old patient with a medical history of splenectomy who was referred to the emergency department with a fever, shivers, and an altered mental state. the symptoms had started twelve hours before. upon arrival in the hospital the patient was tachypnoeic, hypotensive and febrile. blood cultures were taken and broad-spectrum antibiotics were started. he was directly admitted to the intensive care u ...201627581861
evidence for a los and a capsular polysaccharide in capnocytophaga canimorsus.capnocytophaga canimorsus is a dog's and cat's oral commensal which can cause fatal human infections upon bites or scratches. infections mainly start with flu-like symptoms but can rapidly evolve in fatal septicaemia with a mortality as high as 40%. here we present the discovery of a polysaccharide capsule (cps) at the surface of c. canimorsus 5 (cc5), a strain isolated from a fulminant septicaemia. we provide genetic and chemical data showing that this capsule is related to the lipooligosacchar ...201627974829
identification of a new lipoprotein export signal in gram-negative bacteria.bacteria of the phylum bacteroidetes, including commensal organisms and opportunistic pathogens, harbor abundant surface-exposed multiprotein membrane complexes (sus-like systems) involved in carbohydrate acquisition. these complexes have been mostly linked to commensalism, and in some instances, they have also been shown to play a role in pathogenesis. sus-like systems are mainly composed of lipoproteins anchored to the outer membrane and facing the external milieu. this lipoprotein localizatio ...201627795390
modification of the 1-phosphate group during biosynthesis of capnocytophaga canimorsus lipid a.capnocytophaga canimorsus, a commensal bacterium of dog's mouth flora causing severe infections in humans after dog bites or scratches, has a lipopolysaccharide (lps) (endotoxin) with low-inflammatory lipid a. in particular, it contains a phosphoethanolamine (p-etn) instead of a free phosphate group at the c-1 position of the lipid a backbone, usually present in highly toxic enterobacterial gram-negative lipid a. here we show that the c. canimorsus genome comprises a single operon encoding a lip ...201626644381
capnocytophaga canimorsus meningitis diagnosed by 16s rrna pcr.capnocytophaga canimorsus is a common gram-negative anaerobic bacterium from the oral flora of dogs, typically transmitted to humans by dog bites. we report a case of c. canimorsus meningitis where there was (on presentation) no apparent predisposing risk factor and in whom we used 16s rrna pcr gene sequencing to identify the pathogen quickly and to switch to appropriate antibiotic therapy. physicians should be aware of potential c. canimorsus meningitis if conventional cerebrospinal fluid bacte ...201626608220
improvement of identification of capnocytophaga canimorsus by matrix-assisted laser desorption ionization-time of flight mass spectrometry using enriched database.capnocytophaga canimorsus and capnocytophaga cynodegmi can be transmitted from dogs or cats and cause serious human infections. we aimed to evaluate the ability of matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ms) to identify these two capnocytophaga species. ninety-four c. canimorsus and 10 c. cynodegmi isolates identified by 16s rrna gene sequencing were analyzed. using the maldi biotyper database, correct identification was achieved for only 16 of 94 ...201626508105
nmr-based structural analysis of the complete rough-type lipopolysaccharide isolated from capnocytophaga canimorsus. 201526475523
only a subset of c. canimorsus strains is dangerous for humans.capnocytophaga canimorsus are gram-negative bacteria living as commensals in the mouth of dogs and cats. c. canimorsus cause rare but life-threatening generalized infections in humans that have been in contact with a dog or a cat. over the last years we collected 105 c. canimorsus strains from different geographical origins and from severe human infections or healthy dogs. all these strains were analyzed by 16s rdna sequencing and a phylogenetic tree revealed two main groups of bacteria instead ...201526421271
rapid killing of capnocytophaga canimorsus and capnocytophaga cynodegmi by human whole blood and serum is mediated via the complement system.capnocytophaga canimorsus (cani) and capnocytophaga cynodegmi (cyno) are found in the oral cavities of dogs and cats. they can be transmitted to humans via licks or bites and cause wound infections as well as severe systemic infections. cani is considered to be more pathogenic than cyno, but the pathophysiological mechanisms are not elucidated. cani has been suggested to be resistant to serum bactericidal effects. thus, we hypothesized that the more invasive cani would exhibit a higher degree of ...201526405637
diseases transmitted by man's best friend: the dog.the relationship between dogs and humans is ancient and mutually beneficial. dogs have served people well as companions, workmates, guides, and protectors. however, on occasion, dogs may injure humans through biting or may transmit pathogens resulting in a large number of problems ranging from a trivial rash to life-threatening bacteremia. given that there are more than 80 million pet dogs in the united states, it is worth knowing the potential problems that can result from canine exposure. annu ...201526350317
draft genome sequences of three capnocytophaga cynodegmi strains isolated from the oral cavity of healthy dogs.here, we present the draft genome sequences of three strains of capnocytophaga cynodegmi. in contrast to the very close relationship among them, c. cynodegmi and capnocytophaga canimorsus differ dramatically in terms of virulence in humans. comparative genomics provided some understanding on how capnocytophaga species may switch from being dog commensals to human pathogens.201526021913
draft genome sequences of three capnocytophaga canimorsus strains isolated from healthy canine oral cavities.here, we present the draft genome sequences of three strains of capnocytophaga canimorsus, each isolated from a different dog's mouth. genome analysis provided evidence that these organisms may belong to a different nonpathogenic subtype of c. canimorsus.201526021912
draft genome sequences of three capnocytophaga canimorsus strains isolated from septic patients.capnocytophaga canimorsus is a bacterium from the normal oral flora of dogs and cats that causes rare generalized infections in humans. in an attempt to determine whether infections could be caused by a subset of strains and to identify pathogenicity factors, we sequenced the genomes of three strains isolated from human infections.201526021910
capnocytophaga canimorsus: an emerging cause of sepsis, meningitis, and post-splenectomy infection after dog bites.newly named in 1989, capnocytophaga canimorsus is a bacterial pathogen found in the saliva of healthy dogs and cats, and is transmitted to humans principally by dog bites. this review compiled all laboratory-confirmed cases, animal sources, and virulence attributes to describe its epidemiology, clinical features, and pathogenesis. an estimated 484 patients with a median age of 55 years were reported, two-thirds of which were male. the case-fatality rate was about 26%. its clinical presentations ...201525828064
glycan-foraging systems reveal the adaptation of capnocytophaga canimorsus to the dog mouth.capnocytophaga canimorsus is known to form two kinds of cells on blood agar plates (coccoid and bacillary), evoking phase variation. when grown in coculture with animal cells these bacteria appeared only as bacilli, but in the presence of vancomycin they were round, indicating that coccoid shapes likely result from weakening of the peptidoglycan layer. polysaccharide utilization locus 5 (pul5) and sialidase mutant bacteria, unable to retrieve glycans from glycoproteins, grew less than wild-type ...201525736888
acute generalized livedo racemosa caused by capnocytophaga canimorsus identified by maldi-tof ms.independent of the size of the dog and the type of injury, serious infections may follow a dog bite and these may result in the abrupt onset of multiorgan failure. early recognition of the warning signs with regard to the underlying severity of the infection is of the utmost importance. reticulate skin eruptions constitute a precursory phenomenon.201525677725
a rare case of waterhouse-friderichsen syndrome caused by capnocytophaga canimorsus in an immunocompetent patient.a 53-year-old caucasian male with hypertension and active tobacco abuse presented to a community hospital with a 2-day history of vague abdominal pain, myalgia and increased lethargy after being bitten on his right hand by the family dog while camping just 3 days prior to symptom onset. he expired within 90 min upon arrival to our intensive care unit. pre-mortem blood cultures grew a fastidious gram-negative aerobic rod that was identified as capnocytophaga canimorsus. autopsy findings showed mu ...201525676131
capnocytophaga canimorsus bacteremia presenting with acute cholecystitis after a dog bite.capnocytophaga canimorsus is part of normal gingival flora of dogs and cats. the organism can cause septicemia, meningitis, and endocarditis in humans after contact with dogs or cats. in spite of the frequency of gastrointestinal symptoms in c. canimorsus infection patients, specific gastrointestinal disease or clinical images have not been reported. we report a case of c. canimorsus bacteremia presenting with acute cholecystitis in elderly woman. she suffered from general fatigue and right uppe ...201525445385
a case of capnocytophaga canimorsus sacral abscess in an immunocompetent patient.we report a unique case of sacral capnocytophaga canimorsus abscess successfully treated with surgery and antibiotics. close contact to a dog was assumed to be the most likely source of infection. established risk factors for invasive c. canimorsus infection such as splenectomy, alcoholism or overt immunosuppression could not be identified. the role of cigarette smoking, portal of entry and the possible relevance of altered skin microbiota as well as the diagnostic value of polymerase chain reac ...201525182960
new iron acquisition system in bacteroidetes.capnocytophaga canimorsus, a dog mouth commensal and a member of the bacteroidetes phylum, causes rare but often fatal septicemia in humans that have been in contact with a dog. here, we show that c. canimorsus strains isolated from human infections grow readily in heat-inactivated human serum and that this property depends on a typical polysaccharide utilization locus (pul), namely, pul3 in strain cc5. pul are a hallmark of bacteroidetes, and they encode various products, including surface prot ...201525368114
correction: the n-glycan glycoprotein deglycosylation complex (gpd) from capnocytophaga canimorsus deglycosylates human igg. 201526671777
[severe sepsis after dog bite caused by capnocytophaga canimorsus].we describe a case of a life-threatening septicemia resulting from a previous dog bite wound. the isolated bacterium was capnocytophaga canimorsus, a slow-growing gram-negative bacillus commonly found in dog saliva. known risk factors for invasive c. canimorsus infections are alcohol abuse, cigarette smoking, splenectomy or other forms of immunosuppression. any clinician seeing patients with a history of a dog bite should consider this pathogen as a causative agent and take detailed history rega ...201526608488
[epidemiology, microbiology and diagnostics of dog and cat bites related infections].animal bites represent a significant global health problem and account for approximately 1-2% of all visits to the emergency department. the vast majority of animal bite injuries are inflicted by dogs (80-90%,) and cats (5-15%). the most common complication following an animal bite is a wound infection, which tends to be polymicrobial and include both aerobic and anaerobic bacteria mainly of oropharyngeal origin. the likelihood of a cat bite becoming infected is double of that of a dog bite. pas ...201526608484
nmr-based structural analysis of the complete rough-type lipopolysaccharide isolated from capnocytophaga canimorsus.we here describe the nmr analysis of an intact lipopolysaccharide (lps, endotoxin) in water with 1,2-dihexanoyl-sn-glycero-3-phosphocholine as detergent. when hplc-purified rough-type lps of capnocytophaga canimorsus was prepared, (13)c,(15)n labeling could be avoided. the intact lps was analyzed by homonuclear ((1)h) and heteronuclear ((1)h,(13)c, and (1)h,(31)p) correlated one- and two-dimensional nmr techniques as well as by mass spectrometry. it consists of a penta-acylated lipid a with an α ...201424993825
antibiotic treatment following a dog bite in an immunocompromized patient in order to prevent capnocytophaga canimorsus infection: a case report.capnocytophaga canimorsus is a commensal bacterium found in the saliva of dogs and cats. clinically significant infections in humans after a bite are often associated with the presence of immune deficiency. early recognition and appropriate treatment are crucial for patient survival. in addition, patients with immune deficiency are susceptible to serious life-threatening nosocomial infections, which may also influence the prognosis of patients with capnocytophaga canimorsus infection.201424997586
hypertensive emergency and type 2 myocardial infarction resulting from pheochromocytoma and concurrent capnocytophaga canimorsus infection.a diagnosis of myocardial infarction is made using a combination of clinical presentation, electrocardiogram and cardiac biomarkers. however, myocardial infarction can be caused by factors other than coronary artery plaque rupture and thrombosis. we describe an interesting case presenting with hypertensive emergency and type 2 myocardial infarction resulting from pheochromocytoma associated with capnocytophaga canimorsus infection from a dog bite. we also review current literature on the managem ...201425024773
the capnocytophaga canimorsus isolate that caused sepsis in an immunosufficient man was transmitted by the large pine weevil hylobius abietis.the first vector-borne capnocytophaga canimorsus sepsis case is presented. an immunocompetent male who denied any contact with canines and who worked in a sawmill was bitten on his neck by a large pine weevil (hylobius abietis l.; coleoptera: curculionidae). bacteriological diagnosis was confirmed by 16s rrna gene sequence analysis.201424808240
overwhelming capnocytophaga canimorsus infection in a patient with asplenia.patients with asplenia are prone to overwhelming infections due to encapsulated organisms. we report a 62-year-old man presenting with fever and weakness. his medical history was significant for splenectomy and owning a dog as pet. the patient on examination had evidence of animal bite and scratch marks on his lower extremity and developed dry gangrene of multiple digits of his upper extremity soon after admission. the patient's initial blood cultures were positive for gram-negative rods, but no ...201424759159
distribution of capnocytophaga canimorsus in dogs and cats with genetic characterization of isolates.capnocytophaga canimorsus, which is often found in the oral cavities of dogs and cats, is sometimes transmitted to humans, causing severe infection. to elucidate the risk of c. canimorsus in humans and animals, this study was undertaken to characterize this bacterium epidemiologically and genetically. we examined the distribution of c. canimorsus in dogs and cats, and analyzed the correlation between the presence of bacteria and individual factors statistically. we also compared c. canimorsus is ...201424745627
renal failure due to capnocytophaga canimorsus generalized shwartzman reaction from a dog bite (df-2 nephropathy).we report a case of a 54-year-old man who developed gram-negative sepsis with multiorgan failure and generalized shwartzman reaction after sustaining a dog bite. the causative organism was the fastidious gram-negative rod capnocytophaga canimorsus, which is a commensal organism found in the oral flora of dogs and cats. more than 30 years after it was first described and despite technological advances in identification techniques, proper identification of this organism remains a challenge. in lig ...201424688203
[fulminant sepsis due to capnocytophaga canimorsus: diagnosis by matrix-assisted laser desorption/ionization-time of flight mass spectrometry]. 201424103212
capnocytophaga canimorsus sepsis following bmt in a patient with aml: possible association with functional asplenia. 201423974607
facial purpura associated with capnocytophaga canimorsus septicaemia; role of sunlight? 201423816547
capnocytophaga canimorsus infection in cats: abcd guidelines on prevention and management.capnocytophaga canimorsus and capnocytophaga cynodegmi are part of the normal bacterial flora of the oral cavity of dogs and cats. c canimorsus is more pathogenic and causes more severe infections in humans.201323813822
shock following a cat scratch.a 49-year-old man with fever, pain in both legs, purpuras and cyanosis was admitted to hospital. he was a heavy drinker, but did not have diabetes or other immunosuppressive disease. on admission, he was in shock, with haematological findings suggestive of disseminated intravascular coagulation, and liver and kidney failure. the presence of a scratch wound on his face caused by a cat, and linear, gram-negative rods phagocytosed by polynuclear leucocytes on peripheral blood smear suggested capnoc ...201323314879
capnocytophaga canimorsus sepsis with associated thrombotic thrombocytopenic purpura.capnocytophaga canimorsus, a bacterium commonly transmitted via dog bites, is known to cause sepsis in immunocompromised patients. thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are rare complications of infection. the authors present a case of c canimorsus sepsis and thrombotic thrombocytopenic purpura in an asplenic patient and review the relevant literature.201322990045
'bobo-newton syndrome': an unwanted gift from man's best friend.capnocytophaga canimorsus is a facultative gram-negative bacillus that is typically a constituent of the oral flora of dogs and cats. it was first isolated by bobo and newton in 1976 from a man presenting with meningitis following a dog bite. transmission to humans follows various animal-related injuries, which may be gross or subtle. c canimorsus can cause a spectrum of syndromes ranging from skin and soft tissue infection to invasive disease such as meningitis or endocarditis. the present arti ...201324489563
capnocytophaga canimorsus prosthetic aortitis in an hiv-positive woman.a 49-year-old woman with a 15-year history of hiv-hepatitis c virus coinfection had aortic valve and ascending aorta replacement in 2007. she presented with abdominal pain, episodic diarrhea, and profuse sweating in 2010. thoracoabdominal positron emission tomography-computed tomography finally suggested infectious aortitis, a diagnosis confirmed by a blood culture positive for capnocytophaga canimorsus.201323698520
infections in alcoholic liver disease.alcoholic individuals are at increased risk of infection in general, in part because of immune defects. in addition, associated situations, such as depressed mental status, increase risk to specific syndromes such as lung abscess related to depressed consciousness and aspiration. social factors related to hygiene and living situations are also linked to specific microorganisms, such as mycobacteria tuberculosis, bartonella quintana, vibrio vulnificus, and capnocytophaga canimorus..201223101982
the lipopolysaccharide from capnocytophaga canimorsus reveals an unexpected role of the core-oligosaccharide in md-2 binding.capnocytophaga canimorsus is a usual member of dog's mouths flora that causes rare but dramatic human infections after dog bites. we determined the structure of c. canimorsus lipid a. the main features are that it is penta-acylated and composed of a "hybrid backbone" lacking the 4' phosphate and having a 1 phosphoethanolamine (p-etn) at 2-amino-2-deoxy-d-glucose (glcn). c. canimorsus lps was 100 fold less endotoxic than escherichia coli lps. surprisingly, c. canimorsus lipid a was 20,000 fold le ...201222570611
capnocytophaga canimorsus infection presenting with complete splenic infarction and thrombotic thrombocytopenic purpura: a case report.animal bites are typically harmless, but in rare cases infections introduced by such bites can be fatal. capnocytophaga canimorsus, found in the normal oral flora of dogs, has the potential to cause conditions ranging from minor cellulitis to fatal sepsis. the tendency of c. canimorsus infections to present with varied symptoms, the organism's fastidious nature, and difficulty of culturing make this a challenging diagnosis. rarely, bacterial cytotoxins such as those produced by c. canimorsus may ...201223267527
asplenic fulminant sepsis secondary to a dog bite complicated by toxic epidermal necrolysis/stevens-johnson syndrome.we report a case of asplenic fulminant sepsis in australia following a dog bite which was complicated by toxic epidermal necrolysis/stevens-johnson syndrome (tens/sjs). capnocytophaga canimorsus, the infective organism, is a rare cause of septicaemia: a high degree of suspicion of this unusual organism and its early aggressive management is paramount. the diagnostic and management difficulties of tens/sjs in the context of a patient with fulminant sepsis, dic and on inotropes are also highlighte ...201222864159
two cases of infectious purpura fulminans and septic shock caused by capnocytophaga canimorsus transmitted from dogs.we report 2 cases of capnocytophaga canimorsus-induced septicaemia complicated by purpura fulminans in previously healthy individuals, both of whom had been exposed to dog saliva prior to disease. they both presented with purpuric skin lesions, as well as the tetrad of abdominal symptoms, haemolytic anaemia, metabolic acidosis, and renal failure, which may be common in c. canimorsus-associated purpura fulminans. the patients survived after treatment with broad-spectrum antibiotics and supportive ...201222497463
two dog-related infections leading to death: overwhelming capnocytophaga canimorsus sepsis in a patient with cystic echinococcosis.capnocytophaga canimorsus is a fastidious, capnophilic, fusiform, and filamentous gram-negative rod. it is part of the normal oral flora of dogs and cats and can cause an infection in humans, but is of generally low virulence in healthy individuals. a case of fatal sepsis due to capnocytophaga canimorsus in a 46-year-old woman with clinically silent cystic echinococcosis discovered postmortem is present. she had been bitten by a dog 3 days before the symptoms appeared. the family had owned the d ...201222491382
identification of blood and wound isolates of c. canimorsus and c. cynodegmi using vitek2 and maldi-tof.capnocytophaga canimorsus and c. cynodegmi are gram negative bacteria that can be transmitted to humans from dogs or cats and cause serious infections. routine bacteriological methods, including fermentation and phenotypic tests are insufficient to correctly identify c. canimorsus or c. cynodegmi. the aim of this study was to evaluate the performance of vitek2 and maldi-tof in identification of these bacteria. twenty two isolates that were identified as c. canimorsus / c. cynodegmi by 16s rrna s ...201222454088
[capnocytophaga canimorsus meningitis diagnosed by means of a 16s rrna analysis].capnocytophaga canimorsus is a gram-negative bacterial species hosted in the oral cavity of dogs. c. canimorsus can cause sepsis, meningitis and endocarditis. penicillin is the drug of choice. however, the species is a slow-grower and sometimes missed in blood cultures. patients with a history of alcoholism, splenectomy or immunodeficiency are at an increased risk of contracting serious infections with c. canimorsus following dog bites. we report a case story of c. canimorsus meningitis contract ...201222293076
three cases of capnocytophaga canimorsus meningitis seen at a regional hospital in one year.three cases of meningitis caused by the fastidious gram-negative rod capnocytophaga canimorsus have been observed at a regional hospital in 1 y. the difficulties connected with the correct diagnosis by classical culturing methods in contrast to molecular methods, as well as possible reasons for the accumulation of cases, are discussed.201222292539
'biting the hand that feeds': fever and altered sensorium following a dog bite.capnocytophaga canimorsus infection is the most severe and rapidly progressive bacterial infection transmitted by dog bite and fortunately is very rare. the authors describe a 68-year-old gentleman who presented in an acute confusional state 2 days after having been bitten on the left hand by a dog. despite immediate broad-spectrum intravenous antibiotics, he developed significant sequelae including disseminated intravascular coagulopathy, microvascular emboli leading to peripheral necrosis, wid ...201122714608
capnocytophaga canimorsus infections in the netherlands: a nationwide survey.a retrospective nationwide survey on the occurrence of capnocytophaga canimorsus and capnocytopaga cynodegmi infections in the netherlands over 3 years showed 32 cases, of which 31 were caused by c. canimorsus and one by an unspecified oxidase-positive capnocytophaga strain. twenty-eight patients had been diagnosed by blood culture, one by culture from both blood and cerebrospinal fluid (csf), one by culture from a conjunctival swab, and two patients by 16s rrna gene amplification by pcr directl ...201120167010
identification of bacteria associated with feline chronic gingivostomatitis using culture-dependent and culture-independent methods.feline chronic gingivostomatitis (fcgs) is a chronic inflammatory disease of the oral cavity that causes severe pain and distress. there are currently no specific treatment methods available and little is known regarding its aetiology, although bacteria are thought to play a major role. the purpose of this study was to identify the oral bacterial flora in normal and diseased cats. oral swabs were obtained from the palatoglossal folds of eight cats (three normal and five fcgs) and were subjected ...201120828946
capnocytophaga canimorsis a cause of septicaemia following a dog bite: a case review.described in this study is the case of a 53-year-old woman who developed a life-threatening infection caused by the bacterium capnocytophaga canimorsus (c. canimorsus), subsequent to being bitten by a dog. the patient presented to an emergency department with a 24-h history of diarrhoea and vomiting with dehydration but within 36 h of presentation developed an overwhelming severe sepsis with septic shock, disseminated intravascular coagulation, acute renal failure, metabolic acidosis and threate ...201121242095
septicemia due to capnocytophaga canimorsus following dog bite in an elderly male.a previously healthy, 67-year-old, man with past medical history of myocardial infarction and hypertension was rushed to the emergency room after sudden onset of fever, chills, severe rigors, hypotension, tachycardia and vomiting. the patient was diagnosed as being in septic shock, and investigations revealed intracellular gram-negative bacilli in polymorphonuclear leukocytes in the peripheral smear. a history of dog contact was elicited after this very unusual and rare finding. cultures confirm ...201121623093
the genome and surface proteome of capnocytophaga canimorsus reveal a key role of glycan foraging systems in host glycoproteins deglycosylation.capnocytophaga canimorsus are commensal gram-negative bacteria from dog's mouth that cause rare but dramatic septicaemia in humans. c. canimorsus have the unusual property to feed on cultured mammalian cells, including phagocytes, by harvesting the glycan moiety of cellular glycoproteins. to understand the mechanism behind this unusual property, the genome of strain cc5 was sequenced and analysed. in addition, cc5 bacteria were cultivated onto hek 293 cells and the surface proteome was determine ...201121762219
the n-glycan glycoprotein deglycosylation complex (gpd) from capnocytophaga canimorsus deglycosylates human igg.c. canimorsus 5 has the capacity to grow at the expenses of glycan moieties from host cells n-glycoproteins. here, we show that c. canimorsus 5 also has the capacity to deglycosylate human igg and we analyze the deglycosylation mechanism. we show that deglycosylation is achieved by a large complex spanning the outer membrane and consisting of the gpd proteins and sialidase siac. gpdd, -g, -e and -f are surface-exposed outer membrane lipoproteins. gpddef could contribute to the binding of glycopr ...201121738475
[The presence of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in companion animals in the Netherlands].The presence of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in companion animals in The Netherlands. This article reports about a research that is done to determine the presence of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in companion animals in the Netherlands using a species specific PCR in combination with classic microbial isolation. Because of the high presence of the bacteria in the mouth of especially cats and dogs (respectively 21 and 19%) and the severe conseque ...201121870573
Complete genome sequence of the dog commensal and human pathogen Capnocytophaga canimorsus strain 5.Capnocytophaga canimorsus is a commensal Gram-negative bacterium, originally isolated from a dog's mouth, that causes septicemia in humans. C. canimorsus has the unusual ability to feed on host cells, including phagocytes. This capacity depends on surface-exposed glycan-foraging systems. Here we present the first complete genome sequence of a C. canimorsus strain (Cc5).201121914877
'Biting the hand that feeds': fever and altered sensorium following a dog bite.Capnocytophaga canimorsus infection is the most severe and rapidly progressive bacterial infection transmitted by dog bite and fortunately is very rare. The authors describe a 68-year-old gentleman who presented in an acute confusional state 2 days after having been bitten on the left hand by a dog. Despite immediate broad-spectrum intravenous antibiotics, he developed significant sequelae including disseminated intravascular coagulopathy, microvascular emboli leading to peripheral necrosis, wid ...201122101595
capnocytophaga canimorsus sepsis. 201020836255
[fatal sepsis due to capnocytophaga canimorsus after dog bite].a 56-year-old man was bitten by a dog. 8 days later he was admitted to a hospital because of severe deterioration of his clinical situation. he developed the clinical picture of fulminant sepsis. in spite of aggressive intensive care therapy the patient died 24 hours later. capnocytophaga canimorsus was identified from initial blood cultures. this gram-negative rod is part of the normal oral flora of dogs and cats. it can be spread to humans by bites, licking or scratches and causes severe infec ...201020981594
prioritizing emerging zoonoses in the netherlands.to support the development of early warning and surveillance systems of emerging zoonoses, we present a general method to prioritize pathogens using a quantitative, stochastic multi-criteria model, parameterized for the netherlands.201021085625
"beware man's best friend".case report.201021102283
presence of the oral bacterium capnocytophaga canimorsus in the tooth plaque of canines.capnocytophaga canimorsus is a potentially pathogenic microorganism when transmitted to humans from the oral cavity of canines. although there is some knowledge about the frequency of occurrence in canines, it is uncertain whether there is a correlation between its occurrence and lifestyle, health, or breed of dog. samples of tooth plaque from a total of 131 canines were collected, cultured on selective media, and tested using physiological and molecular analyses to help discern the presence of ...201021239122
an unusual case of septic shock in a geriatric patient.capnocytophaga canimorsus is a gram-negative rod that is a normal inhabitant of the oral flora of most dogs, cats and other animals. clinically significant infections of humans by this common organism are extremely rare. we present a case of an 87-year-old woman who presented with septic shock and multiorgan system failure. blood cultures were positive for a gram-negative rod that five days after admission was identified as c. canimorsus. she was treated aggressively with intravenous fluid resus ...201020391818
fatal dog bite in the absence of significant trauma: capnocytophaga canimorsus infection and unexpected death.sudden and unexpected nontraumatic death in individuals with asplenia or hyposplenia is usually due to fulminant bacterial sepsis, most often involving streptococcus pneumoniae, neisseria meningitidis, and hemophilus influenzae. we report a case of a previously well 40-year-old man who died 5 hours after hospital admission. at autopsy waterhouse-friderichsen syndrome was identified and capnocytophaga canimorsus was subsequently isolated on antemortem blood cultures. infection of humans with this ...201020407357
postsplenectomy infection - strategies for prevention in general practice.the spleen plays a crucial role in human defence against infection. patients who are asplenic or hyposplenic are at increased risk of severe sepsis due to specific organisms. overwhelming postsplenectomy infection (opsi) has a mortality rate of up to 50%.201020628676
[permanent hearing loss following dog bite. capnocytophaga canimorsus caused severe infection with sepsis]. 201020812562
capnocytophaga canimorsus.capnocytophaga canimorsus is a commensal bacterium in the oral flora of dogs and cats. the bacterium is a zoonotic agent and has been isolated from humans, infected by dog or cat bites, scratches, licks or simply exposure to dogs or cats. here the infectious agent, its pathogenicity and potential virulence factors, infection in animals and humans, diagnostic methods, prevalence, therapy and prevention are described. suggestions for future research are given.201019268498
prevalence of capnocytophaga canimorsus and capnocytophaga cynodegmi in dogs and cats determined by using a newly established species-specific pcr.capnocytophagacanimorsus and capnocytophagacynodegmi, fastidious gram-negative rods, are commensal microbes thriving in the oral cavities of dogs and cats. c. canimorsus can sometimes cause fatal systemic infections in humans. in the present study, we established a specific pcr which could identify and distinguish c. canimorsus from c. cynodegmi. the prevalence of capnocytophaga spp. in dogs and cats was determined using this method. c. canimorsus was detected in 74% of dogs and 57% of cats. c. ...201020144514
capnocytophaga canimorsus a novel pathogen for joint arthroplasty.we report the case of a 59-year-old man with waldenstrom's macroglobulinemia and active alcohol use who presented with bilateral knee pain 5 years after a bilateral staged tka. cultures of synovial fluid and periprosthetic tissue specimens from both knees yielded, after prolonged anaerobic incubation, a catalase- and oxidase-positive gram-negative bacillus, which was identified as capnocytophaga canimorsus by 16s ribosomal rna pcr analysis. c. canimorsus, an organism that is commonly found in do ...200919067091
a 42-year-old woman with septic shock: an unexpected source.background: dog bites are the most common animal bite injuries occurring in the united states. estimated infection rates range between 15% and 20%. polymicrobial infections are most common. capnocytophaga canimorsus (c. canimorsus) is a gram-negative rod strongly associated with dog bites, and is known to cause life-threatening infection in humans. objectives: 1) outline epidemiology of dog bites in the united states; 2) identify host factors associated with infection, and common pathogens; 3) d ...200919201139
community-acquired capnocytophaga canimorsus meningitis in adults: report of one case with a subacute course and deafness, and literature review.an adult with community-acquired capnocytophaga canimorsus meningitis presented with a subacute course, deafness, and a predominantly lymphocytic csf cell count.200919218001
community-acquired bacterial meningitis in elderly patients: experience over 30 years.clinical characteristics, etiologies, evolution, and prognostic factors of community-acquired bacterial meningitis in elderly patients are not well known. to improve this knowledge, all episodes of community-acquired bacterial meningitis were prospectively recorded and cases occurring in patients >or=65 years old were selected. during the period 1977-2006, 675 episodes in adults (aged >or=18 yr) were recorded, with 185 (27%) in patients aged >or=65 years old; 76 were male and 109 were female, wi ...200919282702
prevalence of capnocytophaga canimorsus in dogs and occurrence of potential virulence factors.capnocytophaga canimorsus is a gram-negative commensal of dog's mouth causing severe human infections. a strain isolated from a human fatal infection was recently shown to have a sialidase, to inhibit the bactericidal activity of macrophages and to block the release of nitric oxide by lps-stimulated macrophages. the present study aimed at determining the prevalence of c. canimorsus in dogs and the occurrence of these hypothetical virulence factors. c. canimorsus could be retrieved from the saliv ...200919285152
resistance of capnocytophaga canimorsus to killing by human complement and polymorphonuclear leukocytes.capnocytophaga canimorsus is a bacterium of the canine oral flora known since 1976 to cause rare but severe septicemia and peripheral gangrene in patients that have been in contact with a dog. it was recently shown that these bacteria do not elicit an inflammatory response (h. shin, m. mally, m. kuhn, c. paroz, and g. r. cornelis, j. infect. dis. 195:375-386, 2007). here, we analyze their sensitivity to the innate immune system. bacteria from the archetype strain cc5 were highly resistant to kil ...200919307219
man's best friend? infective endocarditis due to capnocytophaga canimorsus.infective endocarditis caused by zoonotic microorganisms is an uncommon clinical entity. a 55-year-old man was diagnosed with endocarditis due to capnocytophaga canimorsus, a commensal bacterium contained in the saliva of dogs, that involved the aortic and tricuspid valves and was complicated by a para-aortic valve abscess and aorta-to-right atrial fistula. the patient was successfully treated with antibiotic therapy and surgical intervention. c canimorsus endocarditis should be considered in pa ...200919340358
bite-related and septic syndromes caused by cats and dogs.bite infections can contain a mix of anaerobes and aerobes from the patient's skin and the animal's oral cavity, including species of pasteurella, streptococcus, fusobacterium, and capnocytophaga. domestic cat and dog bite wounds can produce substantial morbidity and often require specialised care techniques and specific antibiotic therapy. bite wounds can be complicated by sepsis. disseminated infections, particularly those caused by capnocytophaga canimorsus and pasteurella multocida, can lead ...200919555903
molecular characterization of capnocytophaga canimorsus and other canine capnocytophaga spp. and assessment by pcr of their frequencies in dogs.capnocytophaga canimorsus can be a virulent pathogen, whereas c. cynodegmi is of low virulence. heterogeneity within these species, their frequency in dogs, and pathogenicity factors are largely unknown. strains from blood cultures from patients presumptively identified as c. canimorsus (n = 25) and as c. cynodegmi by rrs analysis (n = 4), blood cultures from dogs (n = 8), blood cultures from cats (n = 2), and cultures from swabs from dog mouths (n = 53) were analyzed. pcr-restriction fragment l ...200919641058
[an autopsy case involving severe sepsis due to capnocytophaga canimorsus infection].capnocytophaga canimorsus, a commensal bacterium from the carine mouth, causes septicemia in human beings through bites or scratches. we report a case of a 60-year-old man contracting septicemia due to c. canimorsus infection after a dog bite who died less than 12 hours after admission. we observed neutrophils with intracytoplasmic bacilli in the peripheral blood smear. we discuss clinical presentation and autopsy findings.200920034321
capnocytophaga canimorsus endocarditis with root abscess in a patient with a bicuspid aortic valve. 200921977282
capnocytophaga canimorsus septicaemia in an asplenic patient with systemic lupus erythematosus.asplenic patients are highly susceptible to infections with encapsulated bacteria such as capnocytophaga canimorsus, a gram negative bacillus which is a commensal organism in cat and dog saliva. we describe the first case of septic shock due to c canimorsus infection occurring in a 51-year-old woman with functional asplenism related to systemic lupus erythematosus with antiphospholipid antibodies. because of the potential severity of this infection, physicians have to be aware of its occurrence ...200921747901
Refresh
firstprev
123
nextlast
Displaying items 1 - 100 of 229