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ED50 of Hyperbaric Bupivacaine With Fentanyl for Cesarean Delivery Under Combined Spinal Epidural in Normotensive and Preeclamptic Patients.The use of reduced intrathecal doses is advised for spinal anesthesia during cesarean delivery. However, there are inadequate data regarding the minimum effective dose of intrathecal bupivacaine for cesarean delivery. Preeclampsia is caused by an endothelial dysfunction leading to generalized vasoconstriction. Whether this can offset the pregnancy-induced decrease in intrathecal dose requirement caused by epidural venous dilation and consequent thecal compression is not known. There are no data ...201222030721
Clinical nodal staging scores for bladder cancer: a proposal for preoperative risk assessment.Radical cystectomy (RC) with pelvic lymph node dissection (LND) is the standard of care for refractory non-muscle-invasive and muscle-invasive bladder cancer. Although consensus exists on the need for LND, its extent is still debated.201222033174
Excess body fat is associated with higher risk of vertebral deformities in older women but not in men: a cross-sectional study.Thinness is a risk factor for fractures, but the effect of obesity on fracture risk is less clear. We found an association between measures of obesity and prevalence and number of vertebral deformities in women but not in men, in a cross-sectional study of 1,011 participants aged 50-80 years.201221850547
Thyroid function in childhood obesity and metabolic comorbidity.Childhood obesity is a worldwide health problem and its prevalence is increasing steadily and dramatically all over the world. Obese subjects have a much greater likelihood than normal-weight children of acquiring dyslipidemia, elevated blood pressure, and impaired glucose metabolism, which significantly increase their risk of cardiovascular and metabolic diseases. Elevated TSH concentrations in association with normal or slightly elevated free T4 and/or free T3 levels have been consistently fou ...201222130312
n-vinylpyrrolidone dimer, a novel formulation excipient, causes hepatic and thyroid hypertrophy through the induction of hepatic microsomal enzymes in rats.n-vinylpyrrolidone dimer (vpd) is a novel experimental formulation excipient intended for preclinical toxicology studies. in a previous 4-week toxicity study, vpd induced dose-dependent hepatocellular and thyroid gland hypertrophy in sprague-dawley (sd) rats. the objectives of the current investigation were to define the underlying molecular mechanisms of these changes. two separate studies were conducted using male sd rats, daily doses of 300, 1000 or 3,000 mg/kg of vpd, and a positive control ...201222037397
The population level prevalence and correlates of appropriate and inappropriate imaging to stage incident prostate cancer in the medicare population.According to guidelines most men with incident prostate cancer do not require staging imaging. We determined the population level prevalence and correlates of appropriate and inappropriate imaging in this cohort.201222088337
anthrax vaccine antigen-adjuvant formulations completely protect new zealand white rabbits against challenge with bacillus anthracis ames strain spores.in an effort to develop an improved anthrax vaccine that shows high potency, five different anthrax protective antigen (pa)-adjuvant vaccine formulations that were previously found to be efficacious in a nonhuman primate model were evaluated for their efficacy in a rabbit pulmonary challenge model using bacillus anthracis ames strain spores. the vaccine formulations include pa adsorbed to alhydrogel, pa encapsulated in liposomes containing monophosphoryl lipid a, stable liposomal pa oil-in-water ...201222089245
Early Markers of Tubular Dysfunction in Antiretroviral-Experienced HIV-Infected Patients Treated with Tenofovir Versus Abacavir.Abstract Tenofovir disoproxil fumerate (TDF) is an effective nucleoside reverse transcriptase inhibitor for HIV infection but it is potentially nephrotoxic. A selective mithochondrial toxicity has been hypothesized. To assess early markers of renal toxicity, we evaluated a cohort of antiretroviral (ARV)-experienced HIV patients who had been switched from a thymidinic backbone to either a TDF/emtricitabine regimen (TDF; 73 patients) or an abacavir/lamivudine (ABV) regimen (28 patients). Markers ...201222136504
Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial.Whether the addition of radiation therapy (RT) improves overall survival in men with locally advanced prostate cancer managed with androgen deprivation therapy (ADT) is unclear. Our aim was to compare outcomes in such patients with locally advanced prostate cancer.201222056152
Long-term skeletal and dental stability of mandibular symphyseal distraction osteogenesis with a hybrid distractor.The purpose of this study was to examine the long-term skeletal and dental stability of mandibular symphyseal distraction osteogenesis (MSDO) with a tooth-borne and bone-borne hybrid distractor. To differentiate the effects of MSDO from the orthodontic movement and relapse, each phase of treatment was analyzed.201222196186
Social stress-induced hypothyroidism is attenuated by antidepressant treatment in rats.Although serotonergic system has been classically implicated in mood modulation, there has been relatively little study on the relationship between this system and thyroid hormones (TH) economy in stress models. When TH are studied, the effects of stress on thyroid function seems to be complex and depend on the kind and time of stress which counts for the elusiveness of mechanisms underlying changes in TH economy. Herein, we hypothesized that serum TH are affected in a time-dependent fashion aft ...201221903114
Is celiac axis resection justified for T4 pancreatic body cancer?The clinical impact of the distal pancreatectomy with en-bloc celiac axis resection for locally advanced pancreatic body cancer remains unclear.201222088810
Determinants of the cytotoxicity of PrrC anticodon nuclease and its amelioration by tRNA repair.Breakage of tRNA(Lys(UUU)) by the Escherichia coli anticodon nuclease PrrC (EcoPrrC) underlies a host antiviral response to phage T4 infection that is ultimately thwarted by a virus-encoded RNA repair system. PrrC homologs are prevalent in other bacteria, but their activities and substrates are not defined. We find that induced expression of EcoPrrC is toxic in Saccharomyces cerevisiae and E. coli, whereas the Neisseria meningitidis PrrC (NmePrrC) is not. PrrCs consist of an N-terminal NTPase mo ...201222101242
A phase III trial of docetaxel-estramustine in high-risk localised prostate cancer: A planned analysis of response, toxicity and quality of life in the GETUG 12 trial.To assess docetaxel-estramustine in patients with localised high-risk prostate cancer.201222119204
A randomized controlled study investigating static and dynamic balance in older adults after training with pilates.Bird M-L, Hill KD, Fell JW. A randomized controlled study investigating static and dynamic balance in older adults after training with Pilates.201221975148
Comparison of endocrine-mediated effects of two bisphenol A related compounds, 2,2-bis(4-cyanatophyenyl)propane and 4,4'-cyclohexylidenebisphenol, based on subacute oral toxicity studies using rats.The purpose of this study was to compare endocrine-mediated effects of bisphenol A related compounds, 2,2-bis(4-cyanatophyenyl)propane and 4,4'-cyclohexylidenebisphenol with reference to OECD Test Guideline No. 407. Rats were orally gavaged with 0, 4, 20, and 100mg/kg/day of 2,2-bis(4-cyanatophyenyl)propane, and 0, 30, 100, and 300mg/kg/day of 4,4'-cyclohexylidenebisphenol for at least 28 days beginning at 8 weeks of age. Endocrine-mediated effects were not observed in rats given 2,2-bis(4-cyana ...201222093917
Multivisceral and standard resections in colorectal cancer.The current study was designed to identify prognostic factors for long-term survival in patients with advanced colorectal cancer in a consecutive cohort.201221968828
overt and subclinical hypothyroidism: who to treat and how.hypothyroidism denotes deficient production of thyroid hormone by the thyroid gland and can be primary (abnormality in thyroid gland itself) or secondary/central (as a result of hypothalamic or pituitary disease). the term 'subclinical hypothyroidism' is used to define that grade of primary hypothyroidism in which there is an elevated thyroid-stimulating hormone (tsh) concentration in the presence of normal serum free thyroxine (t4) and triiodothyronine (t3) concentrations. subclinical hypothyro ...201222191793
UV-induced DNA damage and DNA repair in ribosomal genes chromatin.Cyclobutane pyrimidine dimers (CPDs) and (6,4) pyrimidine-pyrimidone dimers are the major DNA lesions (or photoproducts) induced by ultraviolet light and are removed by the nucleotide excision repair (NER) pathway. If not repaired, DNA damage can lead to genome instability. The genome is organized into nuclear domains with distinct functions and chromatin structures. Although studies on NER in all chromosomal contexts are important to understand the mechanisms of genome maintenance, we focused o ...201222113285
(32)P-postlabelling for the Sensitive Detection of DNA Adducts.32P-postlabelling is a technique originally described by Kurt Randerath and colleagues for the sensitive detection of damage produced in DNA by reactive chemicals or genotoxins. The procedure essentially entails the enzymatic digestion of DNA to nucleoside 3'-monophosphates which are then radioactively labelled using T4 polynucleotide kinase and [?(32)P]-adenosine triphosphate. Adducted nucleoside-3'-5'-bisphosphates are then separated from their normal counterparts by thin layer chromatography. ...201222147574
number of lymph nodes retrieved is an important determinant of survival of patients with stage ii and stage iii colorectal cancer.the number of lymph nodes retrieved is recognized to be a prognostic factor of stage ii colorectal cancer. however, the prognostic significance of the number of lymph nodes retrieved in stage iii colorectal cancer remains controversial.201222102737
site-specific isotope labeling of long rna for structural and mechanistic studies.a site-specific isotope labeling technique of long rna molecules was established. this technique is comprised of two simple enzymatic reactions, namely a guanosine transfer reaction of group i self-splicing introns and a ligation with t4 dna ligase. the trans-acting group i self-splicing intron with its external cofactor, 'isotopically labeled guanosine 5'-monophosphate' (5'-gmp), steadily gave a 5'-residue-labeled rna fragment. this key reaction, in combination with a ligation of 5'-remainder n ...201222080547
molecular determinants of hiv-2 r5-x4 tropism in the v3 loop: development of a new genotypic tool.objective. the use of ccr5 inhibitors requires a tool to predict human immunodeficiency virus type 2 (hiv-2) tropism, as established in hiv-1. the aim of our study was to identify genotypic determinants of hiv-2 tropism located in the gp105 v3 loop. methods. hiv-2 tropism phenotypic assays were performed on 53 hiv-2 clinical isolates using gfp expressing human osteosarcoma t4 [ghost(3)] cell lines expressing cd4 and ccr5 or cxcr4 coreceptors. the gp105 v3 loop was sequenced and analyzed. results ...201222140264
Assembling linear DNA templates for in vitro transcription and translation.Cell-free expression systems provide straightforward access from genes to the corresponding proteins, involving fewer handling steps than in vivo procedures. A quick procedure to assemble a gene of interest into a linear DNA template together with 3'- and 5'-untranslated regions using a coupled uracil-excision-ligation strategy based on USER Enzyme and T4 DNA ligase. This methodology will be useful for repeated cycles of expression and in vitro selection, in which gene libraries are repeatedly a ...201222130984
dynamics of friendship networks and alcohol use in early and mid-adolescence.similarity in alcohol consumption among adolescent friends could be caused by the influence of friends or by the selection of friends who consume similar levels of alcohol. this article aims to disentangle influence and selection processes while specifically examining changes over time in these processes and possible differences between reciprocal and nonreciprocal friendships.201222152667
impact of histological response after neoadjuvant chemoradiotherapy on recurrence-free survival in uicc-t3 pancreatic adenocarcinoma but not in uicc-t4.although the prognostic benefit of neoadjuvant chemoradiotherapy (ncrt) against pancreatic cancer has been indicated by several reports, it is controversial whether histological response is associated with prognosis. the objective was to explore the relationship between histological response and prognosis in t3 and t4 pancreatic adenocarcinoma.201221934551
viral elution and concentration method for detection of influenza a viruses in mud by real-time rt-pcr.the role of environmental reservoirs in avian influenza virus (aiv) transmission has been investigated during aiv-associated outbreaks. to date, no method has been defined for detection of aiv from mud samples. a procedure using elution and polyethylene glycol (peg) concentration steps was designed to detect aiv by rt-pcr from 42g of raw mud, corresponding to 30g of the solid fraction of mud. rna was recovered with magmax ai/nd viral rna isolation kit (ambion, austin, tx). three elution buffers ...201222036660
gastric cancer eastern experience.several guidelines are used for cancer therapy throughout the world. the japan gastric cancer association guideline, whereby standard surgery for t2 to t4 curable gastric cancer is defined as more than two-thirds gastrectomy with d2 dissection, are widely followed, with further data being gathered from either single institutions or nationwide registry. in the east, d2 dissection shows much better results than less extended surgery followed by adjuvant treatment. adjuvant chemotherapy without rad ...201222098832
multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation.since all-trans retinoic acid (atra) has shown promising results in differentiation therapy, the present study was designed to investigate the effects of atra on thyroid carcinoma and to evaluate the effectiveness of atra in redifferentiation induction of thyroid carcinoma. therefore, we investigated cell growth rate, morphological and nuclear: cytoplasmic ratio, adherent-dependent growth, response to chemotherapy drug following differentiation, t3 and t4 measurement, and critical genes expressi ...201221924320
omega-3 polyunsaturated fatty acids enrichment alters performance and immune response in infectious bursal disease challenged broilers.abstract: background: infectious bursal disease (ibd) results in economic loss due to mortality, reduction in production efficiency and increasing the usage of antibiotics. this study was carried out to investigate the modulatory roles of dietary n-3 polyunsaturated fatty acids (pufa) enrichment in immune response and performance of ibd challenged broiler chickens. methods: a total of 300 day old male broiler chicks were assigned to four dietary n-3 pufa ascending levels as the treatment group ...201222273277
role of spinal cord in regulating mouse kidney: a virally mediated trans-synaptic tracing study.objective: to determine the spinal innervation and neuronal connections is important for studying renal metabolic responses. materials and methods: in this study, the spinal cords of 10 adult male c57bl/6j strain mice were mapped retrograde using injections of pseudorabies virus (prv)-614. the virus, injected into the kidney, was specifically transported to the spinal cord. results: at 5 days after injection of the prv-614, prv-614-positive cells were found in the intermediolateral cell column, ...201222245294
a population-based study of the pattern of terminal care and hospital death in patients with non-small cell lung cancer.non-small cell lung cancer (nsclc) is a major cause of cancer-related death and utilization of health care resources worldwide. significant costs are generated in the months before death, with hospitalization being a major cost driver. moreover, hospital death causes physical and emotional distress. we analyzed factors predicting the likelihood of hospital death from nsclc. patients who died from nsclc (any stage and treatment) during the recent 5-year interval up to 31.12.2010, within a defined ...201222213306
the role of molecular markers and tumor histological type in central lymph node metastasis of papillary thyroid carcinoma.to look for genetic mutations that might predict central compartment lymph node metastasis (lnm) in papillary thyroid carcinoma (ptc) using strict criteria for n0 and n1 disease.201222249628
sequence, structure, and dynamic determinants of hsp27 (hspb1) equilibrium dissociation are encoded by the n-terminal domain.human small heat shock protein 27 (hsp27) undergoes concentration-dependent equilibrium dissociation from an ensemble of large oligomers to a dimer. this phenomenon plays a critical role in hsp27 chaperone activity in vitro enabling high affinity binding to destabilized proteins. in vivo dissociation, which is regulated by phosphorylation, controls hsp27 role in signaling pathways. in this study, we explore the sequence determinants of hsp27 dissociation and define the structural basis underlyin ...201222264079
topical nitrogen mustard therapy in patients with mycosis fungoides or parapsoriasis.background  topical nitrogen mustard is a chemotherapeutic agent used in treatment of mycosis fungoides (mf). objective  to evaluate the response and side effects in patients with mf and parapsoriasis treated with topical nitrogen mustard. methods  a retrospective study of treatment response in 116 patients diagnosed with mf and 71 patients with parapsoriasis and treated with topical nitrogen mustard from 1991 to 2009. results  overall response rate and complete response (cr) rate was 91.4% and ...201222229501
the value of diagnostic whole-body scanning and serum thyroglobulin in the presence of elevated serum thyrotropin during follow-up of anti-thyroglobulin antibody-positive patients with differentiated thyroid carcinoma who appeared to be free of disease after total thyroidectomy and radioactive iodine ablation.background: in the presence of anti-thyroglobulin antibodies (tgab), serum thyroglobulin (tg) might be underestimated. therefore, the american thyroid association does not recommend serum tg after thyroid hormone withdrawal or recombinant human thyrotropin administration (stimulated tg) and diagnostic whole-body scanning (dxwbs) in tgab-positive patients who have serum tg values while on thyroxine (tg-on-t4) of <1 ng/ml. the objective of this study was to determine, in patients with differentiat ...201222224815
prognostic factors for locoregional recurrences in colon cancer.background: there is increased interest in locoregional recurrences of rectal cancer. despite comparable locoregional recurrence rates in colon cancer, only a few studies on locoregional recurrences among colon cancer patients have been published. this study was designed to identify prognostic factors for locoregional recurrences among patients with colon cancer in the netherlands. methods: the study population w ...201222219065
reliability and validity of the multidimensional dyspnea profile (mdp).abstract background:most measures of dyspnea assess a single aspect (intensity or distress) of the symptom. we developed the multidimensional dyspnea profile (mdp) to measure qualities and intensities of the sensory dimension and components of the affective dimension. the mdp is not indexed to a particular activity and can be applied at rest, during exertion, or clinical care. we report on the development and testing of the mdp in patients with a variety of acute and chronic cardiopulmonary cond ...201222267681
clinical and histologic features of inverted papilloma-associated malignancy.the objectives of the study were to analyze the clinical features of inverted papillomas (ip) associated with malignancy and to evaluate the correlation of tumor stage, survival and histolologic features. we conducted a retrospective review of 18 ip associated with malignancy patients. in addition, we compared histopathologic characteristics (tumor differentiation and malignant cell proportion) with clinical outcomes. eleven of the tumors were present on the nasal cavity and 7 on the maxillary s ...201222271282
serum transthyretin concentration is decreased in dogs with nonthyroidal illness.background: hypothyroidism in dogs is often difficult to diagnose owing to nonspecific clinical signs and laboratory test results that can be mimicked by nonthyroidal illness (nti). thyroxine (t4) circulates in blood mainly bound to t4-binding globulin and, to a lesser degree, transthyretin (ttr) and albumin. the concentration of total t4 depends on the concentrations of these binding proteins. objectives: we hypothesized that dogs with nti and decreased serum total t4 concentrations would have ...201222250994
structural mechanism of the phosphorylation-dependent dimerization of the mdc1 forkhead-associated domain.mdc1 is a key mediator of the dna-damage response in mammals with several phosphorylation-dependent protein interaction domains. the function of its n-terminal forkhead-associated (fha) domain remains elusive. here, we show with structural, biochemical and cellular data that the fha domain mediates phosphorylation-dependent dimerization of mdc1 in response to dna damage. crystal structures of the fha domain reveal a face-to-face dimer with pseudo-dyad symmetry. we found that the fha domain recog ...201222234877
wheelchair half-marathon race increases natural killer cell activity in persons with cervical spinal cord injury.study design:non-randomized study.objective:we reported that individuals with cervical spinal cord injury (csci) showed no increase in natural killer cell activity (nkca) in response to 20-min arm exercise. it could be argued that this lack of response was owing to the short duration and intensity of the exercise.setting:the 29th oita international wheelchair marathon race.methods:the present study compared the effects of wheelchair half-marathon race on natural killer (nk) cell count, nkca and ...201222249325
single-port laparoscopic right hemicolectomy: the first 100 resections.: single-port laparoscopy remains a novel technique in the field of colorectal surgery. several small series have examined its safety for colon resection.201222228155
comparisons of polybrominated diphenyl ethers levels in paired south korean cord blood, maternal blood, and breast milk samples.polybrominated diphenyl ethers (pbdes), commonly used flame retardants, have been reported as potential endocrine disruptor and neurodevelopmental toxicants, thus giving rise to the public health concern. the goal of this study was to investigate the relationship between umbilical cord blood, maternal blood, and breast milk concentrations of pbdes in south korean. we assessed pbde levels in paired samples of umbilical cord blood, maternal blood, and breast milk. the levels of seven pbde congener ...201222236587
a systematic review and meta-analysis of the utility of eus for preoperative staging for gastric cancer.background: accurate preoperative staging is important in determining the appropriate treatment of gastric cancer. recently, endoscopic ultrasound (eus) has been introduced as a staging modality. however, reported test characteristics for eus in gastric cancer vary. our purpose in this study was to identify, synthesize, and evaluate findings from all articles on the performance of eus in the preoperative staging of gastric cancer. met ...201222237654
the role of chemoradiotherapy in patients with unresectable t4 breast tumors.purpose: unresectable t4 tumors of the breast are usually treated with systemic therapies, while the role of local therapies remains debatable. this study aims to evaluate the effectiveness of chemoradiotherapy as a part of t4 breast cancer treatment, and to assess the role of local radiotherapies in patients with unresectable t4 breast tumors. materials/methods: between february 1998 and june 2010, 39 unresectab ...201222274798
immune function in female b(6)c(3)f(1) mice is modulated by de-71, a commercial polybrominated diphenyl ether mixture.polybrominated diphenyl ethers (pbdes) are an important class of flame-retardants that are environmentally persistent and bioaccumulative. toxicity of these compounds has become a concern because detectable levels of pbdes are present in humans and wildlife and they are structurally similar to polychlorinated biphenyls (pcbs). this study examined the effects of the commercial penta-bde mixture, de-71, in adult female b(6)c(3)f(1) mice on hematology, serum clinical chemistry, thyroid hormones, ti ...201222214215
high throughput fabrication of disposable nanofluidic lab-on-chip devices for single molecule studies.an easy method is introduced allowing fast polydimethylsiloxane (pdms) replication of nanofluidic lab-on-chip devices using accurately fabricated molds featuring cross-sections down to 60 nm. a high quality master is obtained through proton beam writing and uv lithography. this master can be used more than 200 times to replicate nanofluidic devices capable of handling single dna molecules. this method allows to fabricate nanofluidic devices through simple pdms casting. the extensions of yoyo-1 s ...201223898358
spinal anaesthesia for caesarean section: plain vs hyperbaric bupivacaine.to compare the clinical characteristics of sensory and motor block as well as haemodynamic stability using plain and hyperbaric bupivacaine in spinal anaesthesia for caesarean section.201223862255
the effect of n-3 long chain fatty acids supplementation on plasma peroxisome proliferator activated receptor gamma and thyroid hormones in obesity.peroxisome proliferator-activated receptor gamma (ppar γ) is a transcription factor, which is abundantly expressed in adipose tissue and has a direct link to adiposity. it seems that long-chain polyunsaturated fatty acids (lc-pufas) can regulate ppar γ expression. the purpose of this study was to investigate the effects of n-3lc pufa supplementation on plasma levels of ppar γ and thyroid hormones in obesity.201223825994
strengthening socio-emotional competencies in a school setting: data from the pyramid project.development of socio-emotional competencies is key to children's successful social interaction at home and at school.201223822531
[amyloid polyneuropathies--biochemical and genetic aspects].familial amyloid polyneuropathies (fap) are among the most frequent hereditary amyloidoses. these are serious, most often fatal diseases with autosomal dominant inheritance. fap can be caused by mutations in four genes, namely those encoding transthyretin, al-apoliprotein, gelsolin, and beta-2 microglobulin. transthyretin is a tetramer composed of four identical subunits linked by non covalent bonds and bearing binding sites for thyroxine (t4) and retinol-binding protein (rbp). more than 120 tra ...201223815016
effects of natural bioactive products on the growth and ginsenoside contents of panax ginseng cultured in an aeroponic system.this study was conducted to evaluate the effects of natural bioactive products such as manda enzyme (t1), yangmyeongwon (t2), effective microorganisms (t3), and kelpak (t4) on the growth and ginsenoside contents of panax ginseng cultured in an aeroponic system using a two-layer vertical type of nutrient bath under natural light conditions. the growth of ginseng plants showed specific characteristics according to the positions in which they were cultured due to the difference of light transmittan ...201223717147
the effect of red ginseng extract on inflammatory cytokines after chemotherapy in children.ginseng has been used as an herbal medicine, widely used in asian countries, for long time. recently, beneficial effects for immune functions of korean red ginseng (krg) have been reported in adults. this study was performed to investigate the effects of ginseng on immune functions in children after cessation of chemotherapy or stem cell transplantation for advanced cancer. thirty patients, who were diagnosed and treated for leukemia and solid cancer at the department of pediatrics and adolescen ...201223717140
congenital hypothyroidism screening program in turkey: a local evaluation.it was aimed to evaluate the national congenital hypothyroidism program in terms of thyroid-stimulating hormone (tsh) cut-off level, frequency of cases that required treatment and the stages before treatment in the kocaeli district area. this research was performed with the contribution of kocaeli university medical faculty, pediatric endocrinology department, and the kocaeli local health district. 25,188 babies born in 2009 were evaluated. the previous laboratory data including heel prick sampl ...201223692784
[frequency of subclinical thyroid problems among women during the first trimester of pregnancy].thyroid hormones play an important role in fetal neural and cognitive development. therefore thyroid abnormalities should be detected and treated early during pregnancy.201223677185
evaluation of the seventh edition of the american joint committee on cancer tumour-node-metastasis (tnm) staging system for patients undergoing curative resection of hepatocellular carcinoma: implications for the development of a refined staging system.this study aimed to evaluate the seventh edition of the american joint committee on cancer (ajcc) tumour-node-metastasis (tnm) staging system and to compare its efficacy with those of the fifth and sixth editions of the ajcc staging system and the tnm staging system defined by the liver cancer study group of japan.201223659567
early adiposity rebound and obesity in children with congenital hypothyroidism.earlier adiposity rebound (ar) is correlated with obesity. our goal is to examine rates of obesity and ar in congenital hypothyroidism (cht) and analyze the risk factors of obesity.201223590955
dyslipidemia in subclinical hypothyroidism and the effect of thyroxine on lipid profile.subclinical hypothyroidism (sh) has a prevalence between 4% and 10.5% in various studies. the burden of sh in india is expected to increase with increasing iodine sufficiency. studies have shown conflicting results concerning not only the degree of lipid changes in sh but also the effect of thyroxine substitution therapy. indian studies on dyslipidemia in sh and the effect of thyroxine on lipid profile are currently lacking.201223565423
a case of simultaneous occurrence of graves' disease and hashimoto's thyroiditis.simultaneous occurrence of hashimoto's thyroiditis (ht), and graves' disease (gd) is rare.201223565420
cretinism revisited.cretinism is a condition of severely stunted physical and mental growth due to untreated congenital hypothyroidism. it has been largely eliminated in the developed world, though we still continue to see cases in india.201223565419
empty sella syndrome - beyond being an incidental finding.empty sella is characterized by the herniation of the subarachnoid space within the sella, which is often associated with some degree of flattening of the pituitary gland. this study was undertaken to evaluate the clinical and hormonal profile in patients with empty sella.201223565413
plurihormone secreting pituitary macroadenoma masquerading as thyrotoxicosis: clinical presentation and diagnostic challenges.thyroid stimulating hormone (tsh) secreting adenomas are the rarest type of pituitary adenomas (1:1000000 in the population; 0.2- 2.8% of adenomas). plurihormonal thyrotropic adenomas are even rarer usually having cosecretion of growth hormone (gh) and prolactin. we report perhaps for the first time, tsh, gh, adrenocorticotrophic hormone (acth) and gonadotropins secreting pituitary macroadenoma diagnosed in a 40 year lady presenting with features of thyrotoxicosis for 5 months, amenorrhea for 3 ...201223565411
thyroid disorders in pregnancy.thyroid disorders are common in pregnancy and the most common disorder is subclinical hypothyroidism. due to the complex hormonal changes during pregnancy, it is important to remember that thyroxine requirements are higher in pregnancy. according to recent american thyroid association (ata) guidelines, the recommended reference ranges for tsh are 0.1 to 2.5 miu/l in the first trimester, 0.2 to 3.0 miu/l in the second trimester, and 0.3 to 3.0 miu/l in the third trimester. maternal hypothyroidism ...201223565370
hemolysis in extracorporeal circulation: relationship between time and procedures.extracorporeal circulation (ec) is very important in cardiac surgery but causes significant damage to the blood, including hemolysis.201223515726
laparoscopic excision of local recurrence of renal cell carcinoma.to report a single center's experience with laparoscopic excision of local recurrence of renal cell carcinoma.201223484571
[effects of electro-acupuncture combined general anesthesia on myocardial injury of high blood sugar patients with coronary heart disease in the perioperative phase].to investigate the effects of electro-acupuncture (ea) combined general anesthesia on myocardial injury of high blood sugar patients with coronary heart disease (chd) in the perioperative phase.201223469596
colorimetric assay for t4 polynucleotide kinase activity based on the horseradish peroxidase-mimicking dnazyme combined with λ exonuclease cleavage.t4 polynucleotide kinase (pnk) plays a critical role in various cellular events. here, we describe a novel colorimetric strategy for estimating the activity of pnk and screening its inhibitors taking advantage of the efficient cleavage of λ exonuclease and the horseradish peroxidase-mimicking dnazyme (hrpzyme) signal amplification. a label-free hairpin dna with the sequence of hrpzyme was utilized in the assay. the 5'-hydroxyl terminal of the hairpin dna was firstly phosphorylated in the presenc ...201223427805
traditional chinese medicine etiology and pathogenesis of acquired immune deficiency syndrome in simian immunodeficiency virus-infected chinese rhesus macaques.to investigate the traditional chinese medicine (tcm) etiology and pathogenesis of acquired immune deficiency syndrome (aids) by 18-month observation of chinese rhesus macaques infected with simian immunodeficiency virus (siv) mac239.201223427397
higher dose of methimazole causes frequent adverse effects in the management of graves' disease in children and adolescents.methimazole (mmi) is used as a first-line antithyroid drug in children and adolescents with graves' disease (gd). the aim of this study was to evaluate the correlation between the initial dose of mmi and the clinical course of gd after treatment.201223426814
tsh suppression after intravenous glucocorticosteroid administration in preterm infants.reports have described that, in adults, steroids suppress thyroid-stimulating hormone (tsh) and triiodothyronine (t3) and might suppress thyroxine (t4). no data have been reported for thyroid hormone changes before or after administration of glucocorticoid in preterm infants.201223426812
in congenital hypothyroidism, an initial l-thyroxine dose of 10-12 μg/kg/day is sufficient and sometimes excessive based on thyroid tests 1 month later.current guidelines recommend an initial l-thyroxine (l-t4) dose of 10-15 μg/kg/day for the treatment of congenital hypothyroidism (ch). we analyzed our data for the treatment outcome at 1 month after we noted a frequent overtreatment even at the lower end of this dose range.201223426811
surgical treatment of lumbar vertebral collapse in a patient with parkinson's disease: a case report.parkinson's disease (pd) frequently develops postural abnormalities including extreme neck flexion and trunk flexion. patients with pd sometimes have osteopenia and vertebral deformity due to the destruction of fragile bone can be also associated with the spinal deformity. surgical treatment for these patients is very difficult. we encountered a patient with pd presenting severe trunk sagittal and frontal deformity. the patient had cauda equina syndrome due to progressive vertebral collapse of t ...201223412270
effects of treatment with l-thyroxin on glucose regulation in patients with subclinical hypothyroidism.we examined effects of treatment with 1-thyroxin on glucose regulation in patients with subclinical hypothyroidism.201223409511
the role of selenium in cadmium toxicity: interactions with essential and toxic elements.1. the study was part of a project designed to investigate if organic selenium (se) can ameliorate the toxic effects of cadmium (cd). the main objective of the present study was to investigate, in the chicken, the interactions between se, cd and the following elements: sb, ca, cr, co, cu, fe, pb, mg, mn, mo, ni, v and zn. 2. a total of 300 1-d-old chickens (broilers) were randomly distributed among 4 dietary treatments with 5 replicate pens per treatment. in t1, chickens were fed on a diet with ...201223398427
epidemiology and clinical characteristics of larynx and hypopharynx carcinoma: a comparative study in the hainaut and review of the literature.the epidemiology and clinical picture of laryngeal and hypopharyngeal carcinomas have changed significantly in the past 50 years. the aim of this study was to analyze selected epidemiological and clinical characteristics of laryngeal and hypopharyngeal carcinoma.201223397823
new modalities to treat laryngeal cancer.early laryngeal cancer comprises t1 and t2 stages of the disease. open functional operations achieve local control of the disease in 90-95% of t1 patients and in 70-90% of t2 patients. primary rt achieves local control in 85-94% of t1 tumors and in 70-80% of patients with t2 tumors. introduction of endoscopic laser surgery resulted in further popularization of preservation laryngeal surgery, whereby equally successful treatment results are achieved with minimal invasiveness. quality of voice is ...201223397746
[t∧g: an elementary integrated prognostic system for renal carcinoma n0 m0].introduction: 25-30% of patients with renal cell carcinoma (rcc) develop metastatic progression during follow up. for this reason many prognostic systems have been developed to try to predict the possibility of recurrence. unfortunately these systems are often complex in daily use.
patient and methods: 1089 were selected from a total of 1985 patients undergoing surgery for renal cell cancer. we have excluded patients with a benign diagnosis, lymph node or distant metastases at diagnosis, with no ...201223371278
the effect of protease and xylanase enzymes on growth performance and nutrient digestibility in finisher pigs.two 2 × 2 factorial experiments were conducted to investigate the interaction between xylanase (0 vs. 200 mg/kg) and protease (0 vs. 200 mg/kg) enzyme supplementation on growth performance (exp. 1) and coefficient of ileal and total tract apparent digestibility in grower-finisher pigs (exp. 2). one hundred and twenty-eight individual fed pigs (bw = 34.2 kg; n = 32) were assigned to 1 of 4 dietary treatments: basal diet (t1), t1 + xylanase enzyme (t2), t1 + protease enzyme (t3), or t1 + xylanase ...201223365384
the long-term regulation of food intake and body weight depends on the availability of thyroid hormones in the brain.we evaluated the contribution of the thyroid hormones to the long-term maintenance of feeding behavior and body weight, while distinguishing their direct central effects from those resulting from the metabolic rate in the peripheral tissues.201223391881
association between bipolar affective disorder and thyroid dysfunction.bipolar affective disorder may be associated with alterations in thyroid function. a comprehensive thyroid assessment is important for assessing clinical and sub-clinical imbalances linked to a variety of mood disorders like bipolar affective disorder.201223380316
assessment of left ventricular diastolic dysfunction in sub-clinical hypothyroidism.adverse cardiovascular effect of hypothyroidism has been identified in many studies. early identification of patients with sub-clinical hypothyroidism may lead to early treatment and thereby favourable effect on cardiovascular morbidity and mortality.201223378686
the effect of vitamin a supplementation on thyroid function in premenopausal women.vitamin a and its retinoid derivates play an important role in regulation of normal growth and development. vitamin a has been shown to regulate thyroid hormone metabolism and inhibit thyroid-stimulating hormone (tsh) secretion via down regulation of tsh-β gene expression; however, the effect of vitamin a on thyroid function in obese individuals who are at higher risk of subclinical hypothyroidism is still unclear. in the present study we investigate the impact of vitamin a supplementation on th ...201223378454
[study on mechanism of traditional chinese medicines reducing phlegm and resolving masses in treatment of goiter].to discuss the mechanism of traditional chinese medicines reducing phlegm and resolving masses in treatment of iodine deficiency-induced goiter by observing the expression of growth factors and the balance-regulating mechanism of proliferation and apoptosis.201223373220
advantages of voice reproduction and the development of a biomimetic self-regulating double-clack valve for a prosthesis of the larynx--a feasibility study.the human larynx is a versatile organ. main functions are phonation, protection and regulation of the air ways. patients suffer severely from the diagnosis of a laryngeal carcinoma of the stages t3 and t4. in most cases this diagnosis will lead to a total laryngectomy, which is usually dissatisfying in the sense of postoperative rehabilitation. the postoperative consequences include the loss of the native voice, the loss of regular air ways via mouth and nose, sense of smell, and the inability t ...201223366020
[a case of acute exacerbation of interstitial pneumonia after appendectomy managed with spinal anesthesia].an 88-year-old woman was admitted with acute appendicitis. she had been treated with prednisolone and home oxygen therapy for interstitial pneumonia. her respiratory state on admission was grade 2 of hugh-jones' classification, and plasma kl-6 and sp-d levels were high. seven days after the admission, appendectomy was performed under spinal anesthesia. spinal anesthesia was initiated by injecting 0.5% hyperbaric bupivacaine 2.0ml into l3-4 interspace, and achieved block level was up to t4. durin ...201223362773
[hypothyroidism incidence after multimodal treatment for laryngeal cancer].hypothyroidism following total laryngectomy or radiotherapy treatment for laryngeal cancer is not a rare event, especially in advanced stages. there are no reports on the incidence of hypothyroidism in patients who received chemotherapy and radiotherapy. the objective of this study is to determine the incidence of thyroid dysfunction in a group of patients with laryngeal cancer who underwent surgery as sole treatment, total laryngectomy or radiotherapy alone, and patients with combined treatment ...201223351449
[indication of chemoradiotherapy in patients with unresectable t4 breast tumors]. 201223350460
association of inflammation with atrial fibrillation in hyperthyroidism.the aim of this study was to evaluate the relationship between inflammation and development of atrial fibrillation (af) in patients with hyperthyroidism.201223341838
unusual presentations of a girl with down syndrome: van wyk-grumbach syndrome.van wyk-grumbach syndrome is a rare disease characterized by precocious puberty associated with prolonged hypothyroidism and multicystic enlarged ovaries. a 9-year-old girl with down syndrome visited our hospital for early menarche. at birth, she showed subclinical hypothyroidism [11.8 μg/dl of thyroxine (t4) and 6.05 μiu/ml of thyroid stimulating hormone (tsh)], but she had not been followed up in our clinic. on physical examination, pubertal tanner stage was breast ii and pubic hair i. laborat ...201223329774
comparison of the anesthetic effects of intrathecal levobupivacaine + fentanyl and bupivacaine + fentanyl during caesarean section.regional anesthesia techniques are increasingly preferred for caesarean section. the aim of the present study was to compare the anesthetic effects of levobupivacaine + fentanyl and bupivacaine + fentanyl on the mother and newborn during elective caesarean section under spinal anesthesia.201223327030
analysis of reference interval and age-related changes in serum biochemistry and hematology in the specific pathogen free miniature pig.we analyzed 72 items related to serum biochemistry and hematology in 85 specific pathogen-free (spf) seoul national university (snu) miniature pigs aged 1- to 36-months which originated from a minnesota miniature pig. almost all examined items were similar between male and female pigs. however, some items such as cr level, b/c ratio, c.r.f, ldh, lap and t4 were significantly different between male and female pigs (p<0.05). thirty four examined items showed age-related changes, and the significan ...201223326285
isolation and genotyping of acanthamoeba strains from environmental sources in ahvaz city, khuzestan province, southern iran.acanthamoeba spp. are free-living amoebae commonly found in the environmental sources such as water, soil, and air. this ubiquitous amoeba is the causative agent of amoebic keratitis (ak). the objective of the present study was to investigate the presence of acanthamoeba spp. in water and soil sources in ahvaz city, khuzestan province, southern iran.201223323088
changes of subtests of wechsler memory scale and cognitive function in subjects with subclinical hypothyroidism following treatment with levothyroxine.subclinical hypothyroidism has been reported to be associated with disturbed cognitive function. in this study, changes of subtests of the wechsler memory scale and memory quotient were investigated in subjects with subclinical hypothyroidism following treatment with levothyroxine. the aim of the study was a randomized double blind placebo-controlled clinical trial.201223319987
[prevalence of thyroid abnormalities among psoriatic patients].psoriasis is a chronic papulosquamous cutaneous disease. the etiology is unknown. several biochemical and immunological processes, which appear in patients with genetic predisposition, lead to enhanced proliferation of epidermal cells, and inflammation of the dermis. thyroid gland hormones cause an increase of epidermal growth factor level, which has an important role in keratinocyte proliferation, which may be involved in psoriasis disease.201223316662
[pharyngocutaneous fistula following total laryngectomy].pharyngocutaneous fistula (pcf) is the most common complication after total laryngectomy.201223306575
radioiodine thyroid remnant ablation after recombinant human thyrotropin or thyroid hormone withdrawal in patients with high-risk differentiated thyroid cancer.to supplement limited relevant literature, we retrospectively compared ablation and disease outcomes in high-risk differentiated thyroid carcinoma (dtc) patients undergoing radioiodine thyroid remnant ablation aided by recombinant human thyrotropin (rhtsh) versus thyroid hormone withdrawal/withholding (thw). our cohort was 45 consecutive antithyroglobulin antibody- (tgab-) negative, t3-t4/n0-n1-nx/m0 adults ablated with high activities at three referral centers. ablation success comprised negati ...201223304637
identifying patients who may be candidates for a clinical trial of salvage accelerated partial breast irradiation after previous whole breast irradiation.background and objectives. accelerated partial breast irradiation (apbi) has been proposed as an alternative to salvage mastectomy for patients with ipsilateral breast tumor recurrence (ibtr) after prior breast conservation. we studied factors that are associated with a more favorable local recurrence profile that could make certain patients eligible for apbi. methods. between 1980 and 2005, 157 stage 0-ii breast cancer patients had an ibtr treated by mastectomy. clinical and pathological featur ...201223304530
headache as the sole symptom of nasopharyngeal carcinoma and its clinical implications.this study aimed to investigate the clinical features of npc presenting with headache as the primary or sole symptom.201223304077
[salvage central neck dissection for papillary thyroid cancer].to evaluate the salvage central neck dissection (cnd) for papillary thyroid cancer in the patients with suspicious residual positive lymph nodes in the central compartment.201223302163
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