Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| glutathione s-transferase (gst) of american cockroach, periplaneta americana: classes, isoforms, and allergenicity. | insect glutathione s-transferases (gsts) play important roles in insecticide/drug resistance and stress response. medically, gsts of house dust mites (dermatophagoides pteronyssinus and blomia tropicalis) and german cockroach (blattella germanica) are human allergens. in this study, classes, isoforms and b-cell and allergenic epitopes of gst of american cockroach, periplaneta americana, the predominant species in the tropics and subtropics were investigated for the first time. enzymatically acti ... | 2018 | 29323160 |
| association between kir genes and dust mite sensitization in a brazilian population. | killer cell immunoglobulin-like receptors (kirs), found on the surface of natural killer (nk) cells, play a key role in controlling the innate response. such response depends on a series of cellular interactions between these receptors and hla activating/inhibiting ligands. atopic diseases have been associated with genes that regulate cytokine production and hla genes, which may either protect or predispose to hypersensitivity. | 2018 | 29100942 |
| sensitization to 10 mites in a tropic area. der p and der f are important risk factor for sensitization to other mites from pyroglyphidae, acaridae, chortoglyphidae, and glyciphagidae families. | much is known about the frequency of sensitization to blomia tropicalis, dermatophagoides pteronyssinus and dermatophagoides farinae, although less is known about sensitization to other species and their possible interactions. | 2018 | 28658723 |
| [safety of subcutaneous immunotherapy with tyrosine-adsorbed house dust mite extracts in patients with allergic disease]. | in spite of allergen-specific immunotherapy (sit) multiple benefits, its use is restricted in some countries owing to concerns about severe adverse reactions. | 2018 | 28188713 |
| sputum cytology during late phase responses to inhalation challenge with different allergens. | in mouse models of allergic asthma, exposure to different allergens can trigger distinct inflammatory subtypes in the airways. we investigated if this observation extends to humans. | 2018 | 29337345 |
| optimal cutoff values of allergen-specific immunoglobulin e to house dust mites and animal dander based on skin-prick test results: analysis in 16,209 patients with allergic rhinitis. | the most common tests for allergen sensitization in patients with allergic rhinitis are the skin-prick test (spt) and an in vitro test to detect serum specific immunoglobulin e (sige). however, in vitro allergen test results were interpreted dichotomically as positive or negative at a threshold of 0.35 ku/l of sige, regardless of the patient characteristics or antigen types. | 2018 | 29336285 |
| the draft genome assembly of dermatophagoides pteronyssinus supports identification of novel allergen isoforms in dermatophagoides species. | 2018 | 29320781 | |
| sensitivity to house dust mites allergens with atopic asthma and its relationship with cd14 c(-159t) polymorphism in patients of west bengal, india. | india is the home to around 15-20 million asthmatics, and asthma prevalence is increasing in indian metropolitan area, including kolkata, west bengal. complex interactions of genetic and environmental factors are involved in asthma. genome-wide search for susceptible loci regulating ige response (atopy) have identified a candidate gene cd14 which is most important in the context of allergic responses of respiratory system. this study was aimed to investigate the role of house dust and house dust ... | 2018 | 29045689 |
| lactobacillus gasseri attenuates allergic airway inflammation through pparγ activation in dendritic cells. | lactobacilli prevent the early development of allergic diseases in children and experimental asthma in mice. however, the detailed mechanism underlying this action remains unknown. we aimed to explore the activation pathway in the host by lactobacillus and identify its immunomodulation mechanism in allergic asthma. continuous administration of 107 cfu, but not 109 cfu, of l. gasseri for 4 weeks prevented dermatophagoides pteronyssinus (der p)-induced airway hypersensitivity and inflammation in a ... | 2018 | 29032406 |
| immunomodulation of allergic response in children and adolescents: what we can learn from lymphatic filarial infection. | although it is well known that allergic diseases involve a strong th2 immune response, with production of high levels of specific ige allergen, knowledge on the association between filarial infection and allergies, among paediatric patients is scarce. | 2018 | 29366523 |
| subcutaneous immunotherapy with purified der p1 and 2 suppresses type-2 immunity in a murine asthma model. | allergen-specific immunotherapy can induce long-term suppression of allergic symptoms, reduce medication use and prevent exacerbations of allergic rhinitis and asthma. current treatment is based on crude allergen extracts, which contain immunostimulatory components such as β-glucans, chitins and endotoxin. use of purified or recombinant allergens might therefore increase efficacy of treatment. here, we test application of purified natural group 1 and 2 allergens from dermatophagoides pteronyssin ... | 2018 | 29318623 |
| high-quality assembly of dermatophagoides pteronyssinus genome and transcriptome reveals a wide range of novel allergens. | 2018 | 29305317 | |
| direct intranasal application of the solid phase of immunocap® increases nasal specific immunoglobulin e detection in local allergic rhinitis patients. | the measurement of nasal specific ige (nsige) in local allergic rhinitis (lar) patients is challenging and shows variability. the objective of this work was to evaluate a minimally-invasive method of direct detection of nsige in patients with lar to dermatophagoides pteronyssinus (dp) using an automated immunoassay. | 2018 | 29136342 |
| prevalence and clinical characteristics of local allergic rhinitis in children sensitized to house dust mites. | the prevalence of local allergic rhinitis (lar) in nonatopic children remains unknown. this study aimed to determine the prevalence, clinical characteristics, and severity of lar in children in comparison to classical allergic rhinitis (ar) and nonallergic rhinitis (nar). | 2017 | 29130983 |
| cytokine profile of patients with allergic rhinitis caused by pollen, mite, and microbial allergen sensitization. | allergic rhinitis (ar) is especially prevalent among the population of large cities. immunologically, the airway epithelium is a region where the population of allergen-presenting cells concentrates. these cells actively express a group of receptors of the innate immune system. a specific cytokine profile is its representation. the study was aimed at evaluating the cytokine profile in patients with seasonal and perennial allergic rhinitis. the cytokine profile of nasal secretion and blood serum ... | 2017 | 29109963 |
| ectopic lymphoid tissues support local immunoglobulin production in patients with chronic rhinosinusitis with nasal polyps. | the contribution of ectopic lymphoid tissues (elts) to local immunoglobulin hyperproduction in patients with chronic rhinosinusitis with nasal polyps (crswnp) is unclear. | 2017 | 29103995 |
| analysis of predicted b and t-cell epitopes in der p 23, allergen from dermatophagoides pteronyssinus. | house dust mite (hdm) allergy is the leading cause of ige-mediated hypersensitivity. therefore identifying potential epitopes in the dermatophagoide pteronyssinus 23 (der p 23), a major house dust mite allergen will aid in the development of therapeutic vaccines and diagnostic kits for hdm allergy. experimental methods of epitope discovery have been widely exploited for the mapping of potential allergens. this study sought to use immunoinformatic methods to analyze the structure of der p 23 for ... | 2017 | 29081610 |
| house dust mite allergy: its innate immune response and immunotherapy. | over the past few decades, allergic diseases have become increasingly prevalent worldwide. house dust mite (hdm) is the most important domestic source for allergic diseases such as allergic rhinitis, asthma and atopic dermatitis. dermatophagoides pteronyssinus (der p) is the major environmental allergen in southeast asia because of the humid and warm environment is suitable for its growth. in the recent year, role of hdm allergen in allergic inflammation through innate immune system has been wel ... | 2017 | 29079219 |
| evolution and predictive value of ige responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life. | the evolution of the ige response to the numerous allergen molecules of dermatophagoides pteronyssinus is still unknown. | 2017 | 27793411 |
| association between asthma and sensitization to allergens of dermatophagoides pteronyssinus. | little is known about the role of molecular diagnosis in house dust mite (hdm) allergy. in this study, we investigated the association between the sensitization profile of adolescent and adult hdm-allergic patients and asthma in a region with high rates of exposure to hdm. | 2017 | 27373988 |
| are dust mite allergens more abundant and/or more stable than other dermatophagoides pteronyssinus proteins? | 2017 | 27771129 | |
| [evaluation of sensitization to der p 1 and der p 2 in a pediatric population of the north of portugal]. | in portugal, data on the role of der p 1 and der p 2 in patients with house dust mite (hdm) allergy are scarce. allergen-specific immunotherapy (sit) is the only treatment that improves symptoms, reduces the need for pharmacological therapy and modifies the natural history of the disease. with this study, the authors aim to understand the local epidemiology and to clarify if the molecular assay of major allergens is advantageous in deciding and/or modifying the decision to initiate sit in childr ... | 2017 | 29290503 |
| the activation and function of il-36γ in neutrophilic inflammation in chronic rhinosinusitis. | although increased accumulation of neutrophils has been noted in chronic rhinosinusitis (crs), the function and regulation of neutrophils in crs are largely unknown. il-36 family cytokines may play an important role in neutrophilic inflammation. | 2017 | 29274415 |
| conjugation of nitrated acetaminophen to der p1 amplifies peripheral blood monocyte response to der p1. | an association of acetaminophen use and asthma was observed in the international study of asthma and allergies in childhood study. however there are no clear mechanisms to explain an association between acetaminophen use and immunologic pathology. in acidic conditions like those in the stomach and inflamed airway, tyrosine residues are nitrated by nitrous and peroxynitrous acids. the resulting nitrotyrosine is structurally similar to 2,4-dinitrophenol and 2,4-dinitrochlorobenzene, known haptens ... | 2017 | 29228007 |
| physiological effects of brominated flame retardants on nc/nga mice. | brominated flame retardants (bfrs) are used as an additive or reactive components in various materials. regarding their health concerns, their immunotoxicity have not been clarified yet. | 2017 | 29219636 |
| immunotherapeutic efficacy of liposome-encapsulated refined allergen vaccines against dermatophagoides pteronyssinus allergy. | allergen specific immunotherapy (ait) can modulate the allergic response causing a long-term symptom subsidence/abolishment which leads to reduced drug use and prevention of new sensitization. ait of house dust mite allergy (hdm) using the mite crude extract (ce) as the therapeutic agent is not only less effective than the ait for many other allergens, but also frequently causes adverse effects during the treatment course. in this study, mouse model of dermatophagoides pteronyssinus (dp) allergy ... | 2017 | 29182623 |
| visualization of dendritic cells' responses in atopic dermatitis: preventing effect of emollient. | atopic dermatitis (ad) is a chronic and multifactorial inflammatory skin disease involving various dendritic cells such as epidermal langerhans cells (lc) and inflammatory dendritic epidermal cells (idecs). most of the clinical studies was performed on isolated cells, and thus, it would be useful to characterize directly on the human epidermal tissue the first cellular events occurred during the ad. the suction blister method was used to obtain whole epidermis samples and interstitial cutaneous ... | 2017 | 29178515 |
| great flood and aeroallergen sensitization in children with asthma and/or allergic rhinitis. | flooding may affect aeroallergen sensitization. | 2017 | 29161054 |
| dermatophagoides pteronyssinus immunotherapy changes the t-regulatory cell activity. | subcutaneous specific immunotherapy (scit) has been shown to modify the dermatophagoides pteronissinus (dp) allergic response, characterized by generation of treg cells. however, studies have reported no changes in the proportion of treg cells after immunotherapy, indicating that the effects may be due to modifications in their regulatory activities. we aimed to determine whether tregs generated by dp-scit can switch the allergic response to tolerant and study the involvement of suppressive cyto ... | 2017 | 28931869 |
| dermatophagoides pteronyssinus lytfm encoding an nlpc/p60 endopeptidase is also present in mite-associated bacteria that express lytfm variants. | the bodies and faecal pellets of the house dust mite (hdm), dermatophagoides pteronyssinus, are the source of many allergenic and nonallergenic proteins. one of these, the 14-kda bacteriolytic enzyme lytfm, originally isolated from the spent hdm growth medium, may contribute to bacteriolytic activity previously detected by zymography at 14 kda in the culture supernatants of some bacterial species isolated from surface-sterilised hdm. based on previously reported findings of lateral gene transfer ... | 2017 | 28904857 |
| role of b cells in th cell responses in a mouse model of asthma. | the importance of b lymphocytes to present antigens for antibody production is well documented. in contrast, very little is known about their capacity to influence cd4+ t-cell activation during a primary or secondary response to allergens. | 2017 | 28889953 |
| der p 1 and der p 2 specific immunoglobulin e measurement for diagnosis of dermatophagoides pteronyssinus allergy: a systematic review and meta-analysis. | a clinical history of allergic symptoms and a skin-prick test with house-dust mite crude extracts are standard diagnostic procedures for dermatophagoides pteronyssinus allergy. specific immunoglobulin e (ige) responses to der p 1 and der p 2 allergens have been used for the diagnosis of d. pteronyssinus allergy; however, evaluation of the diagnostic performance of der p 1 and der p 2 specific ige (sige) produced inconsistent findings. we sought to evaluate the diagnostic accuracy of der p 1 sige ... | 2017 | 28814355 |
| draft genome sequence of dermatophagoides pteronyssinus, the european house dust mite. | dermatophagoides pteronyssinus is the european dust mite and a major source of human allergens. here, we present the first draft genome sequence of the mite, as well as the ab initio gene prediction and functional analyses that will facilitate comparative genomic analyses with other mite species. | 2017 | 28798186 |
| local allergic rhinitis in adult patients with chronic nasal symptoms. | local allergic rhinitis (lar) remains an underdiagnosed condition characterized by the local production of ige antibodies during the natural exposure to aeroallergens. the prevalence of lar in adult patients with a previous diagnosis of non-ar was assessed. | 2017 | 28787729 |
| sensitization to dust mite defines different phenotypes of asthma: a multicenter study. | indoor allergens are risk factors for asthma: thus, the characterization of indoor air quality is important for studying environment-health relationships in children. in particular, dermatophagoides pteronyssinus is the dominant allergen for asthma. we cross-sectionally investigated the relationships among respiratory symptoms and function, airway inflammation, allergen sensitization, and indoor allergen concentration. | 2017 | 28783215 |
| the effect of allergen-induced bronchoconstriction on concentration of 5-oxo-ete in exhaled breath condensate of house dust mite-allergic patients. | arachidonic acid metabolites regulate several aspects of airway function including inflammation, muscle contraction and mucous secretion. | 2017 | 28763131 |
| long form of thymic stromal lymphopoietin of keratinocytes is induced by protein allergens. | a growing body of evidence suggests that epicutaneous sensitization of protein allergens induces immediate-type hypersensitivity (ihs) following induction of type 2 immune responses in animals and humans. thymic stromal lymphopoietin (tslp) derived from keratinocytes is a cytokine that can activate dendritic cells and has been implicated in development of inflammatory type 2 helper t-cells. however, there is no direct evidence that allergens directly regulate tslp expression in keratinocytes. th ... | 2017 | 28720058 |
| innate function of house dust mite allergens: robust enzymatic degradation of extracellular matrix at elevated ph. | exposure to the house dust mite dermatophagoides pteronyssinus (d.p.) increases the risk for developing allergic diseases in humans and their best friends, the dogs. here, we explored whether this allergenic mite via its enzymes may impact the cutaneous extracellular matrix (ecm), which critically determines epithelial barrier integrity both structurally and functionally. | 2017 | 28702111 |
| alteration of -656(g/t) and -607(c/a) polymorphisms in interleukin-18 (il-18) gene in house dust mite-sensitive allergic rhinitis patients in thailand. | allergic rhinitis (ar) is an ige-mediated inflammation of the nasal membranes, which is naturally triggered by aeroallergens. house dust mites (hdm) are the most common inhalant allergens. interleukin-18 (il-18) has been established as an essential cytokine that can activate the generation of ige. this randomized controlled study aimed to identify the possible relationship of the genetic variations in the il-18 gene with ar in mite-sensitive thai patients. study subjects consisted of 150 ar pati ... | 2017 | 28692122 |
| efficacy of nasal cellulose powder in the symptomatic treatment of allergic rhinitis: a randomized, double-blind, placebo-controlled trial. | nasal cellulose powder (ncp), which can prevent from binding an allergen to nasal mucosa, may reduce allergic rhinitis (ar) symptoms in dust mite-sensitized children. this study was conducted to assess the efficacy of ncp in improving clinical symptoms of a nasal airflow limitation and the response of nasal inflammatory cells. | 2017 | 28677359 |
| profiling the extended cleavage specificity of the house dust mite protease allergens der p 1, der p 3 and der p 6 for the prediction of new cell surface protein substrates. | house dust mite (hdm) protease allergens, through cleavages of critical surface proteins, drastically influence the initiation of the th2 type immune responses. however, few human protein substrates for hdm proteases have been identified so far, mainly by applying time-consuming target-specific individual studies. therefore, the identification of substrate repertoires for hdm proteases would represent an unprecedented key step toward a better understanding of the mechanism of hdm allergic respon ... | 2017 | 28654001 |
| the safety profile of subcutaneous allergen immunotherapy in children with asthma in hangzhou, east china. | the aim of the current study is to evaluate the prevalence, severity and possible risk factors of systemic reactions (srs) to subcutaneous allergen immunotherapy (scit) in children and adolescents with asthma in hangzhou, east china's zhejiang province. | 2017 | 28629672 |
| analysis of mechanism of pm2.5 and house dust mite antigen der p1 in attack stage of child asthma. | we analyzed the influence of pm2.5 and house dust mite antigen der p1 on the treatment of child asthma attack. | 2017 | 28617540 |
| dust mite allergen-specific immunotherapy increases il4 dna methylation and induces der p-specific t cell tolerance in children with allergic asthma. | allergen-specific immunotherapy (allergen-sit) is a highly effective treatment for children with allergic asthma (aa), an immune-mediated chronic disease leading to bronchial muscle hypertrophy and airway obstruction in response to specific allergens. t helper cells and secreted cytokines play important roles in the pathogenesis of asthma, and epigenetic modulation controls genes important for t cell development and cytokine expression. this study evaluated t helper cell-secreted cytokines and d ... | 2017 | 28603280 |
| body mass index and skin reactivity to histamine and dermatophagoides pteronyssinus in children and adolescents followed in a pediatric allergy service. | rationale. recent data suggest that the nutritional status assessed by body mass index (bmi) is positively associated with skin reactivity to histamine in children. objective. to study the relation between bmi and skin reactivity to histamine and dermatophagoides pteronyssinus in allergic children and adolescents. methods. the medical charts of patients attended in our outpatient clinic between 2013 and 2014 (n = 972) were evaluated. only patients with asthma, allergic rhinitis or wheezing infan ... | 2017 | 28497673 |
| sensitivity to house dust mites allergens in patients with allergic asthma in erzincan province, turkey. | to investigate the sensitivity of allergic asthma (aa) patients to house dust mites (hdm) by conducting skin tests, measuring total and specific ige antibodies to dermatophagoides pteronyssinus and d. farinae mites, and examining hdm fauna in patients' homes. | 2017 | 28483732 |
| dietary shifts have consequences for the repertoire of allergens produced by the european house dust mite. | products manufactured from mass-cultured house dust mites, currently commercialized for the diagnosis and immunotherapy of allergy, are heterogeneous in terms of allergen composition and thus present concerns to regulatory authorities. the most abundant species, dermatophagoides pteronyssinus (trouessart) (astigmata: pyroglyphidae), produces 19 allergenic proteins. many of these are putatively involved in mite digestive physiology and metabolism. this study aimed to evaluate the effects of mite- ... | 2017 | 28429373 |
| a real life comparison between allergenic extracts and allergenic molecules. | serum ige assay is a mainstay step in the allergy work up. allergenic extracts and molecular components are available at present. this real life study compared the serum specific ige levels against allergenic extracts with allergenic molecules in patients allergic to parietaria, betulaceae, and mites. this retrospective real life study included 489 subjects with respiratory allergy. inclusion criteria were 1) documented diagnosis of allergic rhinitis (ar) and/or allergic asthma, and 2) documente ... | 2017 | 28417623 |
| comparative analysis of cluster versus conventional immunotherapy in patients with allergic rhinitis. | the present study aimed to compare the efficacy and safety of subcutaneous immunotherapy with dermatophagoides pteronyssinus standardized extract administered in conventional and cluster immunotherapy regiments for patients with persistent allergic rhinitis. a total of 60 patients with moderate to severe allergic rhinitis caused by dust mites were treated for 1 year with either conventional immunotherapy (n=30) or cluster immunotherapy (n=30). nasal conjunctival symptoms and signs were assessed ... | 2017 | 28352357 |
| at-rvd1 modulates the activation of bronchial epithelial cells induced by lipopolysaccharide and dermatophagoides pteronyssinus. | bronchial epithelial cells are essential to airways homeostasis; however, they are also involved in exacerbation of airway inflammatory responses of patients with conditions such as asthma. dermatophagoides pteronyssinus (dp), the most important allergen, and lipopolysaccharide (lps), both of which are present in house dust mites (hdm), can activate immune and structural cells (such as bronchial epithelial cells) and modulate the airway inflammation in asthma patients. resolvin d1 (rvd1) and its ... | 2017 | 28322829 |
| specific nasal provocation test with dermatophagoides pteronyssinus, monitored by acoustic rhinometry, in children with rhinitis. | currently, the diagnosis of allergic rhinitis (ar) is arrived at predominantly by a clinical history and by systemic sensitization tests, but specific nasal provocation tests (npt) may establish a better direct correlation between etiologic surveyed allergens and nasal symptoms. | 2017 | 28234142 |
| effectiveness of specific sublingual immunotherapy in korean patients with atopic dermatitis. | sublingual immunotherapy (slit) with house dust mites (hdm) preparation has recently been proven to be beneficial for treating allergic rhinitis and asthma. however, there has been no report regarding the efficacy and safety of slit in korean patients with atopic dermatitis (ad). | 2017 | 28223739 |
| neonatal immune state is influenced by maternal allergic rhinitis and associated with regulatory t cells. | maternal influences contribute to the origin of allergic diseases, but the mechanisms are not clear. the current literature prompted the role of epigenetics in the development of allergic diseases. we sought to investigate the roles of regulatory t (treg) cells and forkhead box p3 (foxp3) dna methylation in the process of maternal transmission of allergic rhinitis (ar) susceptibility. | 2017 | 28102058 |
| antigenic determinants of der p 1: specificity and cross-reactivity associated with ige antibody recognition. | der p 1 and der f 1 are major allergens from dermatophagoides pteronyssinus and d. farinae, respectively. an analysis of antigenic determinants on both allergens was performed by site-directed mutagenesis. the analysis was based on the x-ray crystal structures of the allergens in complex with fab fragments of three murine mabs that interfere with ige ab binding: the two der p 1-specific mabs 5h8 and 10b9, and the cross-reactive mab 4c1. on one hand, selected residues in the epitopes for mab 5h8 ... | 2017 | 28039303 |
| usefulness of allerkin house dust mite extract for nasal provocation testing. | we evaluated the clinical usefulness of allerkin (lofarma) for nasal provocation testing (npt) in patients with rhinitis symptoms, by examining changes in nasal symptoms and acoustic parameters after exposure to house dust mite (hdm) extract. | 2017 | 27992712 |
| dermatophagoides pteronyssinus: changes in sensitisation in the past 11 years and comparison with other centres in mexico. | house dust mites are a ubiquitous air allergen in the human habitat. it has been shown that exposure to them is a fundamental factor in sensitisation and development of atopic disease. the objective of the study was to analyse changes in sensitisation to dermatophagoides pteronyssinus (der p.) in children treated in a tertiary level care hospital in mexico city for a period of 11 years and compare with other studies carried out in mexico. | 2017 | 27914830 |
| quality control of house dust mite extracts by broad-spectrum profiling of allergen-related enzymatic activities. | diagnosis and immunotherapy of allergy against mites is based on complex extracts from large-scale cultures. however, the analysis of their composition using specific antibodies is limited. by taking advantage of the prevailing enzymatic nature of mite allergens, we have developed a broad-spectrum biochemical method for the standardization of native mite products. | 2017 | 27460687 |
| effects of domestic chemical stressors on expression of allergen genes in the european house dust mite. | the expression of allergen genes in house dust mites is influenced by temperature and relative humidity, but little is known of the impacts of other environmental factors that may alter the repertoire of allergens released by mites in home microhabitats. bioassays were conducted in concave microscope slides in combination with real-time quantitative polymerase chain reaction (rt-qpcr) to analyse gene expression of 17 allergens of dermatophagoides pteronyssinus (acariformes: pyroglyphidae) expose ... | 2017 | 27753116 |
| european symposium on the awareness of allergy: report of the promotional campaign in the european parliament (26-28 april 2016). | from 26 to 28 of april 2016, an allergy awareness campaign was organized by the european academy of allergy and clinical immunology and the european federation of allergy and airway diseases patients associations in the european parliament in brussels, with support of the european parliament's interest group on allergy and asthma and was co-hosted by the members of the european parliament david borrelli, sirpa pietikainen and nessa childers. skin prick tests (spts) were performed to gain attenti ... | 2017 | 27696452 |
| preservation of epithelial cell barrier function and muted inflammation in resistance to allergic rhinoconjunctivitis from house dust mite challenge. | an emerging paradigm holds that resistance to the development of allergic diseases, including allergic rhinoconjunctivitis, relates to an intact epithelial/epidermal barrier during early childhood. conceivably, the immunologic and genomic footprint of this resistance is preserved in nonatopic, nonallergic adults and is unmasked during exposure to an aeroallergen. | 2017 | 27658763 |
| il-23 secreted by bronchial epithelial cells contributes to allergic sensitization in asthma model: role of il-23 secreted by bronchial epithelial cells. | il-23 has been postulated to be a critical mediator contributing to various inflammatory diseases. dermatophagoides pteronyssinus (der p) is one of the most common inhalant allergens. however, the role of il-23 in der p-induced mouse asthma model is not well understood, particularly with regard to the development of allergic sensitization in the airways. the objective of this study was to evaluate roles of il-23 in der p sensitization and asthma development. balb/c mice were repeatedly administe ... | 2017 | 27864285 |
| patterns of inhalant allergen sensitization and geographical variation in korean adults: a multicenter retrospective study. | inhalant allergen sensitization is one of the major factors involved in the pathogenesis of allergic respiratory diseases. however, the sensitization is determined by interactions between genetic and environmental factors. thus, testing panels of inhalant allergens may differ among geographical areas. here we aimed to determine 10 common inhalant allergens in korean adult patients with suspected respiratory allergies and to examine the variation between different geographical locations. | 2017 | 28913989 |
| house dust mite sensitization is inversely associated with plasma 25-hydroxyvitamin d3 levels in patients with severe atopic dermatitis. | the relationship between atopic dermatitis (ad) and low vitamin d levels has been studied. emerging evidence has implicated vitamin d as a critical regulator of immunity, playing a role in both the innate and cell-mediated immune systems. however, the effect of vitamin d on house dust mite (hdm) sensitization in patients with ad has not been established. | 2017 | 28761286 |
| a randomized, double-blind, placebo controlled trial of sublingual immunotherapy with house-dust mite extract for allergic rhinitis. | this study was designed to evaluate the efficacy and safety of sublingual immunotherapy (slit) with house-dust mite (hdm) extract in chinese patients with hdm-induced allergic rhinitis (ar). | 2017 | 28716168 |
| prolonged effect of allergen sublingual immunotherapy for house dust mites in elderly patients. | the prolonged effect of allergen immunotherapy is unknown, especially in older patients. | 2017 | 28668244 |
| proteases of dermatophagoides pteronyssinus. | since the discovery that der p 1 is a cysteine protease, the role of proteolytic activity in allergic sensitization has been explored. there are many allergens with proteolytic activity; however, exposure from dust mites is not limited to allergens. in this paper, genomic, transcriptomic and proteomic data on dermatophagoides pteronyssinus (dp) was mined for information regarding the complete degradome of this house dust mite. d. pteronyssinus has more proteases than the closely related acari, d ... | 2017 | 28587273 |
| subcutaneous immunotherapy for allergic asthma in a single center of korea: efficacy, safety, and clinical response predictors. | allergen-specific immunotherapy is the only causal treatment for allergic diseases. however, the efficacy of immunotherapy may vary around the world due to differences in climate, the nature of aero-allergens and their distribution. the aim of this study was to describe the effects of subcutaneous immunotherapy (scit) in korean adults with allergic asthma (aa). as a retrospective cohort study, we reviewed medical records for 627 patients with aa in korea who were sensitized to house dust mite (h ... | 2017 | 28581269 |
| comparison of the immunocap assay and advansure™ alloscreen advanced multiplex specific ige detection assay. | the advansure™ alloscreen assay is an advanced multiplex test that allows for simultaneous detection of specific ige (sige) against multiple allergens. for precise identification of causative allergens in allergic patients, we compared this new multiplex sige assay with the immunocap assay, which is currently the gold-standard method for sige detection. | 2017 | 28540992 |
| specific immunoglobulin e and immunoglobulin g4 toward major allergens of house-dust mite during allergen-specific immunotherapy. | specific immunoglobulin e (sige) and sigg4 to house-dust mite (hdm) major allergens during allergen immunotherapy (ait) and their clinical relevance remain unclear. | 2017 | 28490399 |
| detailed two-dimensional gel proteomic mapping of the feces of the house dust mite dermatophagoides pteronyssinus and comparison with d. farinae: reduced trypsin protease content in d. pteronyssinus and different isoforms. | major domestic mite allergens are present in feces. we present a detailed 2d-e-ms/ms proteomic analysis of the dermatophagoides pteronyssinus feces. precise cultivation yielded a pure fecal extract. we detected differences in fecal allergens/digestive enzymes between d. pteronyssinus and d. farinae using 2d-e fingerprinting, including unique information on species-specific protease isoforms. proteomic analysis was performed by 2d-e coupled with maldi-tof/tof identification. the species-specific ... | 2017 | 28442447 |
| a pilot study of intralymphatic immunotherapy for house dust mite, cat, and dog allergies. | several recent clinical trials reported that intralymphatic immunotherapy (ilit) for some allergens, such as cat dander and pollen, induce tolerance more rapidly than conventional subcutaneous or sublingual immunotherapy, have a comparable duration of effect after only 3 injections, and do not provoke serious local or systemic reactions. however, the efficacy and safety of ilit are using dermatophagoides farinae (df), dermatophagoides pteronyssinus (dp), and dog, which are indoor allergens that ... | 2017 | 28293934 |
| mite allergen extracts and clinical practice. | to provide physicians, researchers, and other interested health care professionals with information about how mite source materials and allergen extracts are manufactured, including the critical process parameters that can affect the final composition of allergenic extracts available for clinical use. | 2017 | 28284531 |
| comparative analysis of serum allergen sige detected by western blotting and fluorescent enzyme immunoassay. | various new methods to diagnose allergens have gradually developed in recent years. the present study aimed to evaluate the diagnostic performance and clinical utility of allergy-q detection system (proteometech inc., korea) on serum allergen-specific ige (sige). | 2017 | 28271691 |
| sublingual immunotherapy dosing regimens: what is ideal? | sublingual immunotherapy (slit) is a treatment for allergic respiratory diseases that has demonstrated efficacy and safety. several formulations of slit are now available worldwide for treatment of allergic rhinitis (ar). grass tablets containing 15 to 25 μg of group 5 major allergen reduced combined ar symptoms and medication use by 23% to 41% in 3 treatment years and 2 follow-up years. ragweed pollen tablets (12 μg of ambrosia artemisiifolia 1) and liquid extracts (50 μg of ambrosia artemisiif ... | 2017 | 28065336 |
| the natural history of atopic dermatitis and its association with atopic march. | atopic dermatitis (ad) is the first manifestation of atopic march. the natural history of ad and predictive factors for atopic march have not been widely studied in asia. | 2017 | 27996288 |
| exhaled nitric oxide helps discriminating asthmatic children with and without positive specific ige to aeroallergens. | aeroallergen sensitization may predict higher fractional exhaled nitric oxide (feno) levels. | 2017 | 29223148 |
| comparison of two different assays and the predictive value of allergen components in house dust mite allergy. | in house dust mite (hdm) allergy diagnostics, the immulite, immunocap and assays for allergen components (nder p 1 and rder p 2) are available. | 2017 | 29130795 |
| clinical evaluation of techniques for measuring nasal-specific immunoglobulin e in pediatric patients. | currently used methods for collecting nasal-specific immunoglobulin e (ige) require administration of a large amount of saline into the nostrils, which is difficult in children. we designed two methods that are easy to use in children. we measured nasal-specific ige and evaluated clinical characteristics of nasal-specific ige in pediatric rhinitis. this study included 82 patients who visited kyungpook national university children's hospital from december 2014 to july 2016 with rhinitis symptoms. ... | 2017 | 29115083 |
| optimal cutoff values of allergen-specific immunoglobulin e to house dust mites and animal dander based on skin-prick test results: analysis in 16,209 patients with allergic rhinitis. | the most common tests for allergen sensitization in patients with allergic rhinitis are the skin-prick test(spt) and an in vitro test to detect serum specific immunoglobulin e (sige). however, in vitro allergen test results were interpreted dichotomically as positive or negative at a threshold of 0.35ku/l of sige, regardless of the patient characteristics or antigen types. | 2017 | 29070165 |
| house dust mite prevalence in the house of patients with atopic dermatitis in mashhad, iran. | being exposed to house dust mites intensifies atopic dermatitis. this study has investigated the contamination rate with dermatophagoides mites in patient's residential home with atopic dermatitis. | 2017 | 29062855 |
| association between hla genes and dust mite sensitivity in a brazilian population. | type i hypersensitivity, also known as ige-mediated allergy, is a complex, multifactorial condition whose onset and severity are influenced by both genetic and environmental factors. mite allergens stimulate the production of humoral response (ige), especially in children, which is closely involved in atopic asthma and rhinitis. | 2017 | 27780790 |
| the differences in serum quantitative specific ige levels induced by dermatophagoides pteronyssinus, dermatophagoides farinae and blomia tropicalis sensitization in intermittent and persistent allergic asthma. | house dust mites (hdm) are an important inhalant allergen in allergic asthma. however, molecular diagnostic study of specific ige to hdm allergens has not been done in indonesia. in addition, the association of quantitative specific ige measurement with asthma severity has not been investigatedd. this study aimed to investigate the difference of serum quantitative specific ige levels induced by dermatophagoides (d.) pteronyssinus, d. farinae and blomia tropicalis sensitization in intermittent an ... | 2017 | 29348379 |
| [type i hypersensitivity to nocturnal lepidoptera in a costa rican allergic population]. | allergic patients are routinely tested for various allergens including molds, food, pollen, cockroaches and house dust mites; however, there are patients who present allergy symptoms but show negative results in prick tests with the available allergens. | 2017 | 26239328 |
| [oral anaphylaxis by ingestion of mite contaminated food in panama city, 2011-2014]. | oral mite anaphylaxis (oma), or pancake syndrome, occurs in atopic individuals when eating starchy foods contaminated by mites, which induce moderate or severe, even fatal, allergic reactions. this syndrome is usually seen in tropical and subtropical environments,where conditions for the growth of domestic mites are given. oral mite anaphylaxis has been associated with hypersensitivity to acetylsalicylic acid (asa)-non-steroidal anti-inflammatory drugs (nsaid) and physical exercise. | 2017 | 25958374 |
| mite fauna assessment in houses of two distinct socioeconomic groups from southern brazil. | house dust mites (hdm) are the main source of aeroallergens worldwide, yet epidemiological differences between socioeconomic factors in association with this medical condition have not been studied in the south region of brazil. to assess the prevalence of hdm in two socioeconomically distinct populations of patients with allergic asthma or rhinitis, the differences between samples from houses of high-income families and low-income families were analyzed. mite samples were collected between july ... | 2017 | 29281052 |
| species identification and prevalence of house dust mites as respiratory allergen in kindergartens of the bandar abbas city. | the aim of this study was to identify the species and prevalence of house dust mites (hdms) in kindergartens in bandar abbas, south of iran. in this study 10 kindergartens were selected randomly in five areas of bandar abbas. two dust samples were collected from each sampling place with a vacuum cleaner. mites were isolated and mounted in hoyer's medium and identified using a morphology-based key. in total, 1758 mites were collected and identified, whichconsisted of five species: dermatophagoide ... | 2017 | 28601053 |
| variables affecting interpretation of skin prick test results. | both performer- and device-dependent variabilities have been reported in sizes of wheal responses to skin prick tests. | 2017 | 27779146 |
| comparison between specific ige levels and skin prick test results of local and imported american cockroach, dog, cat, dust mites and mold allergen extracts. | skin prick test (spt) and specific ige (sige) are approved for evaluation of allergen sensitization. local allergen extracts are less expensive and more available but need to be standardized. | 2017 | 27362401 |
| bronchial hyperresponsiveness in adults with seasonal and perennial rhinitis: is there a link for asthma and rhinitis? | epidemiological studies have shown that asthma and rhinitis often coexist in the same patients and the prevalence of asthma is greater in patients with rhinitis. the aim of this study was to evaluate the differences in bronchial reactivity in subjects with seasonal and perennial rhinitis. we enrolled 128 subjects with seasonal or perennial allergic rhinitis divided into three groups: a with perennial rhinitis and allergy to dermatophagoides pteronissynus; b with seasonal rhinitis and allergy to ... | 2017 | 12593791 |
| cetirizine, a second-generation h1 antagonist, modulates rantes and mcp-1 levels in allergic rhinitis. | chemokines and their receptors are involved in several allergic diseases. we measured rantes and mcp-1 levels in sera of allergic rhinitis patients, and also we evaluated the effect of cetrizine, a second-generation h1 antagonist, on these chemoattractant proteins. 15 subjects were studied (10 males and 5 females; mean age: 26.7 years). they were suffering from perennial or seasonal allergic rhinitis induced by dermatophagoides pteronyssinus (8 patients) or by grasses (7 patients). rantes and mc ... | 2017 | 12590873 |
| blomia tropicalis allergen 5 (blo t 5) t-cell epitopes and their ability to suppress the allergic immune response. | blomia tropicalis is the major asthma allergen in the tropics comparable to dermatophagoides pteronyssinus. however, little is known about the b. tropicalis epitopes recognized by t cells. our aim was to identify the t-cell epitopes in the major b. tropicalis allergen, blo t 5, and investigate the potential of the corresponding peptides to inhibit the allergic inflammatory lung response. c57bl/6 mice were immunized with plasmid dna encoding blo t 5 and t-cell epitopes identified using the interf ... | 2017 | 28581024 |
| [blomia tropicalis: a house dust mite in the tropics]. | blomia tropicalis is a mite that belongs to the superfamily of glycyphagidae. initially described as a storage mite, it is now considered as a house dust mite of tropical and sub-tropical areas. | 2017 | 28502519 |
| sensitization to aspergillus species is associated with frequent exacerbations in severe asthma. | severe asthma is a largely heterogeneous disease with varying phenotypic profiles. the relationship between specific allergen sensitization and asthma severity, particularly in asia, remains unclear. we aim to study the prevalence of specific allergen sensitization patterns and investigate their association with outcomes in a severe asthma cohort in an asian setting. | 2017 | 28461762 |
| allergens involved in the cross-reactivity of aedes aegypti with other arthropods. | cross-reactivity between aedes aegypti and mites, cockroaches, and shrimp has been previously suggested, but the involved molecular components have not been fully described. | 2017 | 28434865 |
| seasonal variation of allergenic acarofauna from the homes of allergic rhinitis and asthmatic patients. | house dust mites (hdms) play positive role in causing various kinds of allergenic manifestations such as allergic rhinitis (ar), asthma, dermatitis, and urticaria. hdms are prevalent in temperate regions but various studies have shown the prevalence of hdms in tropical and subtropical countries. the present study was conducted from march 2015 to february 2016. during the study period, a total of 500 dust samples were collected from 125 homes of 125 patients suffering from ar and asthma. from the ... | 2017 | 29244180 |
| sensitization by subcutaneous route is superior to intraperitoneal route in induction of asthma by house dust mite in a murine mode. | to develop a new experimental model of chronic allergic pulmonary disease induced by house dust mite, with marked production of specific immunoglobulin e (ige), eosinophilic inflammatory infiltrate in the airways and remodeling, comparing two different routes of sensitization. | 2017 | 26761554 |
| local allergic rhinitis is an independent rhinitis phenotype: the results of a 10-years follow-up study. | the knowledge about the natural history of local allergic rhinitis (lar) is limited. one unmeet question is to demonstrate whether lar should be considered the first step in the development of allergic rhinitis (ar) or an independent phenotype. the aim of this study was to prospectively evaluate the natural history of a population with lar, the potential conversion to ar with systemic atopy, and the development of asthma during 10 years. | 2017 | 28833265 |
| natural history of skin prick test reactivity: a 20-year prospective study of a random population sample of children and adolescents. | allergic reactions to airborne allergens may have important consequences for affected individuals and are believed to be unstable through life, although evidence from longitudinal studies is limited. | 2017 | 28599992 |
| report of common aeroallergens among allergic patients in northeastern iran. | the prevalence of atopic diseases has increased in recent decades dramatically. the most common aeroallergens in northeastern iran have not been fully defined. determining the most common aeroallergens in allergic patients based on the skin prick test (spt) was aimed in this investigation. | 2017 | 28393056 |
| longitudinal vitamin d deficiency is inversely related to mite sensitization in early childhood. | there are few studies addressing the longitudinal analysis of vitamin d deficiency and its impact on the development of atopic diseases in early childhood. | 2017 | 29240264 |