Publications
Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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urogenital schistosomiasis and soil-transmitted helminthiasis (sth) in cameroon: an epidemiological update at barombi mbo and barombi kotto crater lakes assessing prospects for intensified control interventions. | the crater lakes of barombi mbo and barombi kotto are well-known transmission foci of schistosomiasis and soil-transmitted helminthiasis having had several important control initiatives previously. to collect contemporary epidemiological information, a cross-sectional survey was undertaken inclusive of: signs and symptoms of disease, individual treatment histories, local water, sanitation and hygiene (wash)-related factors and malacological surveillance, with molecular characterisation of specim ... | 2017 | 28238285 |
potential contribution of adult populations to the maintenance of schistosomiasis and soil-transmitted helminth infections in the siavonga and mazabuka districts of zambia. | a majority of zambian children live in impoverished communities that lack safe water and proper sanitation, exposing them to urogenital and intestinal helminths. efforts to mitigate this plight have been implemented through mass drug administration aimed at deworming school-age and under-five children against schistosomiasis and soil-transmitted helminths. however, the disease status of adults living in the same communities as the treated children remains unknown. the aim of this study was to de ... | 2017 | 27180827 |
schistosomiasis and human immunodeficiency virus in men in tanzania. | schistosomiasis is a parasitic worm infection that affects over 260 million individuals worldwide. women with schistosome infections have been demonstrated to have a 4-fold increase in the odds of human immunodeficiency virus (hiv) infection compared with women without schistosome infections. a relationship between schistosome and hiv infections has not been clearly defined in men. among 674 men aged 18-50 years living in rural tanzania, we identified 429 (63.6%) who had a schistosome infection ... | 2017 | 28167600 |
hematospermia in a returned traveler. | hematospermia is a common complaint among patients seen in outpatient urology clinics. the differential diagnosis is broad and includes inflammatory, infectious, neoplastic, structural, systemic, and traumatic causes. the most common infectious causes are uropathogens and sexually transmitted infections. however, with increasing global travel, physicians must maintain a high clinical suspicion for pathogens not endemic to their region, including echinococcus, mycobacterium tuberculosis, and schi ... | 2017 | 28163813 |
the complete mitochondrial genome of orthocoelium streptocoelium (digenea: paramphistomidae) for comparison with other digeneans. | orthocoelium streptocoelium is a common paramphistome species parasitizing the rumen and/or reticulum of small ruminants, leading to significant losses. this study first determined the complete mitochondrial (mt) genome of o. streptocoelium. the complete mt genome of o. streptocoelium was amplified, sequenced, assembled, analysed and then compared with those of other digeneans. the entire mt genome of o. streptocoelium is 13,800 bp in length, which is smaller than those of other digeneans except ... | 2017 | 27030161 |
coinfection with schistosoma haematobium and plasmodium falciparum and anaemia severity among pregnant women in munyenge, mount cameroon area: a cross-sectional study. | background. malaria and urogenital schistosomiasis are coendemic in mount cameroon area. this study investigated the prevalence of s. haematobium, p. falciparum, and coinfections and their effect on anaemia in pregnancy. methods. pregnant women reporting for antenatal care (anc) clinic visit in munyenge were enrolled. s. haematobium and p. falciparum infections were determined by urine filtration and microscopy, respectively. haemoglobin (hb) levels were measured using haemoglobinometer. of 250 ... | 2017 | 28168042 |
urogenital schistosomiasis during pregnancy is associated with low birth weight delivery: analysis of a prospective cohort of pregnant women and their offspring in gabon. | an estimated 40 million women of childbearing age suffer from schistosomiasis. animal models indicate a deleterious effect of maternal schistosomiasis on pregnancy outcomes. to date there is a lack of epidemiological evidence evaluating schistosomiasis-related morbidity in pregnancy. this study was designed to describe the impact of urogenital schistosomiasis on pregnancy outcomes in a highly endemic region of central africa. pregnant women attending antenatal clinics in fougamou and lambaréné, ... | 2017 | 28003151 |
detecting hybridization in african schistosome species: does egg morphology complement molecular species identification? | hybrid parasites may have an increased transmission potential and higher virulence compared to their parental species. consequently, hybrid detection is critical for disease control. previous crossing experiments showed that hybrid schistosome eggs have distinct morphotypes. we therefore compared the performance of egg morphology with molecular markers with regard to detecting hybridization in schistosomes. we studied the morphology of 303 terminal-spined eggs, originating from 19 individuals in ... | 2017 | 28215207 |
efficacy of praziquantel on schistosoma haematobium and re-infection rates among school-going children in the ndumo area of umkhanyakude district, kwazulu-natal, south africa. | despite its low cure rates and possible resistance, praziquantel (pzq) is the only drug available for schistosomiasis treatment. hence, monitoring its efficacy is crucial. this study assessed the efficacy of pzq, determined re-infection and incidence rates of schistosoma haematobium infection among school-going children in the ndumo area, kwazulu-natal. | 2017 | 28385154 |
selecting accurate post-elimination monitoring tools to prevent reemergence of urogenital schistosomiasis in morocco: a pilot study. | after alleged stop of transmission of schistosomiasis and further down the line in post elimination settings, sensitive tools are required to monitor infection status to prevent potential re-emergence. in rahala, where transmission cycle of schistosoma haematobium is interrupted since 2004 but where 30% of snails are still infected by s. bovis, potential human s. bovis infection can't be excluded. as methods based on egg-counts do not provide the required sensitivity, antibody or antigen assays ... | 2017 | 28381240 |
the role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer. | urogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. how urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke schistosoma haematobium, the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. these kind of compounds have been implicated in other cancers. aiming for enhanced understanding of the pathogenesis of the urogenital schistosomiasis-induced bladder ca ... | 2017 | 28345469 |
schistosomiasis is more prevalent than previously thought: what does it mean for public health goals, policies, strategies, guidelines and intervention programs? | mapping and diagnosis of infections by the three major schistosome species (schistosoma haematobium, s. mansoni and s. japonicum) has been done with assays that are known to be specific but increasingly insensitive as prevalence declines or in areas with already low prevalence of infection. this becomes a true challenge to achieving the goal of elimination of schistosomiasis because the multiplicative portion of the life-cycle of schistosomes, in the snail vector, favors continued transmission a ... | 2017 | 28327187 |
carcinosarcoma of the bladder following local schistosomiasis infection. | a young patient from central africa presented acute renal insufficiency due to extrinsic compression of the distal ureters by a pelvic mass. after initial medical management, a biopsy revealed poorly differentiated bladder cancer and schistosoma haematobium eggs embedded in the bladder wall. the initial workup showed evidence of locoregional disease. radical cystectomy with an incontinent urinary diversion was performed with no complications. carcinosarcoma of the bladder was diagnosed by pathol ... | 2017 | 28325721 |
development of urinary bladder pre-neoplasia by schistosoma haematobium eggs and chemical carcinogen in mice. | schistosoma haematobium is a biocarcinogen of human urinary bladder (ub). the present study investigated developing ub cancer mouse model by injecting s. haematobium eggs into the bladder wall and introduction of chemical carcinogens. histopathological findings showed mild hyperplasia to epithelial vacuolar change, and high grade dysplasia. squamous metaplasia was observed in the s. haematobium eggs+ndma group at week 12 but not in other groups. immunohistochemistry revealed significantly high e ... | 2017 | 28285503 |
assessing the prevalence of urogenital schistosomaisis and transmission risk factors amongst school-aged children around mapé dam ecological suburbs in malantouen district, cameroon. | urogenital schistosomiasis is a parasitic infection of public health importance that affects over 112 million people worldwide. the study aimed at assessing the urogenital schistosomiasis prevalence and risk factors of transmission around mape dam suburds in malantouen district, west, cameroon. | 2017 | 28260525 |
ultrasonographic evaluation of urinary tract morbidity in school-aged and preschool-aged children infected with schistosoma haematobium and its evolution after praziquantel treatment: a randomized controlled trial. | schistosoma haematobium infections are responsible for significant urinary tract (ut) complications. schistosomiasis control programs aim to reduce morbidity, yet the extent of morbidity in preschool-aged children and the impact of treatment on morbidity reduction are not well studied. | 2017 | 28222149 |
[urinary schistosomiasis and cancer]. | the existence of a link between urinary schistosomiasis (us) and bladder carcinoma was first suspected by c. goebel in 1905. in 1911, a.r ferguson, who was a professor of pathology and microbiology at the faculty of medicine in cairo, published a more detailed survey from 40 autopsies, and reported a likely association of bladder carcinoma with granulomas caused by us. subsequently, published results from several studies reinforced ferguson's hypothesis. moreover, in most countries where us was ... | 2017 | 28185084 |
nitrative and oxidative dna damage in infection-related carcinogenesis in relation to cancer stem cells. | infection and chronic inflammation have been recognized as important factors for carcinogenesis. under inflammatory conditions, reactive oxygen species (ros) and reactive nitrogen species (rns) are generated from inflammatory and epithelial cells, and result in the formation of oxidative and nitrative dna lesions, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodg) and 8-nitroguanine. the dna damage can cause mutations and has been implicated in inflammation-mediated carcinogenesis. it has bee ... | 2017 | 28163802 |
divergent effects of schistosoma haematobium exposure on intermediate-host snail species bulinus nasutus and bulinus globosus from coastal kenya. | schistosoma haematobium infection causes urogenital schistosomiasis, a chronic inflammatory disease that is highly prevalent in many parts of sub-saharan africa. bulinid snails are the obligate intermediate hosts in the transmission of this parasite. in the present study, bulinus globosus and bulinus nasutus snails from coastal kenya were raised in the laboratory and exposed to miracidia derived from sympatric s. haematobium specimens to assess the species-specific impact of parasite contact and ... | 2017 | 28115664 |
prevalence and risk factors of undernutrition among schoolchildren in the plateau central and centre-ouest regions of burkina faso. | multiple factors determine children's nutritional status, including energy and nutrient intake, recurrent infectious diseases, access (or lack thereof) to clean water and improved sanitation, and hygiene practices, among others. the "vegetables go to school: improving nutrition through agricultural diversification" (vgts) project implements an integrated school garden programme in five countries, including burkina faso. the aim of this study was to determine the prevalence of undernutrition and ... | 2017 | 28100278 |
diagnosing urogenital schistosomiasis: dealing with diminishing returns. | urogenital schistosomiasis, caused by schistosoma haematobium, is the most prevalent form of schistosomiasis affecting humans, and can result in severe bladder, kidney, ureteral, and genital pathologies. chronic infection with s. haematobium has been linked with bladder cancer and increased risk for hiv infection. as mass drug administration with praziquantel increases in an attempt to transition from control to elimination of schistosomiasis, the need for updated, more sensitive diagnostic tool ... | 2017 | 28094201 |
parasitic infections and maternal anaemia among expectant mothers in the dangme east district of ghana. | parasitic infections are of public health concern globally, particular among at risk groups such as pregnant women in developing countries. the presence of these parasites during pregnancy potentiate adverse effects to both the mother and the unborn baby. this study sought to establish the prevalence of some parasitic agents among antenatal attendees in the dangme east district of ghana. a cross-sectional prospective study was conduct between april and july, 2012. venous blood specimens were col ... | 2017 | 28057071 |
appendicular bilharzioma: an unusual cause of acute intestinal obstruction in childhood (a case report at charles de gaulle paediatric teaching hospital of ouagadougou). | the authors report the case of a 12-year-old boy admitted to the surgical emergency department of charles de gaulle paediatric teaching hospital of ouagadougou for acute abdominal pain. a strangulation of the terminal ileum by a tumour-like appendix wound around the bowel loop was seen during operation. the histological examination of the removed appendix disclosed eggs of schistosoma haematobium and concluded to bilharzian appendicitis. a course of praziquantel treatment was instituted, and the ... | 2017 | 28051054 |
estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertility. | urogenital schistosomiasis is a chronic infection caused by the human blood fluke schistosoma haematobium. schistosomiasis haematobium is a known risk factor for cancer leading to squamous cell carcinoma of the urinary bladder (scc). this is a neglected tropical disease endemic in many countries of africa and the middle east. schistosome eggs produce catechol-estrogens. these molecules are metabolized to active quinones that cause alterations in dna (leading in other contexts to breast or thyroi ... | 2017 | 28018158 |
sm-p80-based schistosomiasis vaccine: preparation for human clinical trials. | mass antiparasitic drug administration programs and other control strategies have made important contributions in reducing the global prevalence of helminths. schistosomiasis, however, continues to spread to new geographic areas. the advent of a viable vaccine and its deployment, coupled with existing control efforts, is expected to make significant headway towards sustained schistosomiasis control. in 2016, science ranked the schistosomiasis vaccine as one of the top 10 vaccines that needs to b ... | 2017 | 27865740 |
bladder cancer incidence and mortality: a global overview and recent trends. | bladder cancer has become a common cancer globally, with an estimated 430 000 new cases diagnosed in 2012. | 2017 | 27370177 |
epidemiology of schistosomiasis among villagers of the new halfa agricultural scheme, sudan. | schistosomiasis is one of the major communicable diseases of public health and socioeconomic importance in developing countries. this study assessed the situation of schistosomiasis among villagers of the new halfa agricultural scheme, sudan. | 2017 | 27095977 |
biochemical and biophysical methodologies open the road for effective schistosomiasis therapy and vaccination. | schistosomiasis caused by blood-dwelling flukes, namely schistosoma mansoni and schistosoma haematobium is a severe debilitating disease, widespread in sub-saharan africa, the middle east, and south america. developing and adult worms are unscathed by the surrounding immune effectors and antibodies because the parasite is protected by a double lipid bilayer armor which allows access of nutrients, while binding of specific antibodies is denied. | 2017 | 27062905 |
expression levels and codon usage patterns in nuclear genes of the filarial nematode wucheraria bancrofti and the blood fluke schistosoma haematobium. | synonymous codons are used with different frequencies, a phenomenon known as codon bias, which exists in many genomes and is mainly resolute by mutation and selection. to elucidate the genetic characteristics and evolutionary relationship of wucheraria bancrofti and schistosoma haematobium we examined the pattern of synonymous codon usage in nuclear genes of both the species. the mean overall gc contents of w. bancrofti and s. haematobium were 43.41 and 36.37%, respectively, which suggests that ... | 2017 | 27048929 |
[epidemiology of schistosomiasis in the periurban area of sotuba, 10 years mass treatment began in mali]. | the objective of this work was to describe the epidemiology of schistosomiasis 10 years after mass administration of praziquantel began in sotuba, mali. | 2017 | 26986093 |
the effect of hookworm infection and urinary schistosomiasis on blood hemoglobin concentration of schoolchildren living in northern mozambique. | this study aims to assess the association between schistosomiasis and hookworm infection with hemoglobin levels of schoolchildren in northern mozambique. through a cross-sectional survey, 1,015 children from five to 12 years old in the provinces of nampula, cabo delgado and niassa were studied. hookworm infection and urinary schistosomiasis were diagnosed, through ritchie and filtration methods, with a prevalence of 31.3% and 59.1%, respectively. hemoglobin levels were obtained with a portable p ... | 2017 | 24879000 |
parasitic infections in pregnancy decrease placental transfer of antipneumococcus antibodies. | many factors can influence maternal placental antibody transfer to the fetus, which confers important immune protection to the newborn infant. however, little is known about the effect of maternal parasitic infection on placental antibody transfer. to investigate this, we selected from a parent study of 576 pregnant kenyan women four groups of women with term deliveries (≥37 weeks), including uninfected women (n = 30) and women with solo infections with malaria (n = 30), hookworm (n = 30), or sc ... | 2017 | 28404574 |
anemia and growth retardation associated with schistosoma haematobium infection in mali: a possible subtle impact of a neglected tropical disease. | the aim of this cross-sectional study was to investigate a possible association of schistosoma haematobium with child growth development and describe a plausible schistosomiasis-related anemia in children and adults in a highly schistosomiasis endemic area of mali. | 2017 | 28673023 |
the substructure of three repetitive dna regions of schistosoma haematobium group species as a potential marker for species recognition and interbreeding detection. | schistosoma haematobium is the causative agent of human urogenital schistosomiasis affecting ~112 million people in africa and the middle east. the parasite is transmitted by snails of the genus bulinus, which also transmit other closely related human and animal schistosomes. the accurate discrimination of s. haematobium from species infecting animals will aid effective control and elimination programs. previously we have shown the utility of different repetitive nuclear dna sequences (drai, sh7 ... | 2017 | 28764739 |
prevalence and molecular characterisation of schistosoma haematobium among primary school children in kebbi state, nigeria | schistosomiasis is the major source of morbidity in sub-saharan africa and asia. it is estimated that 207 million people are infected, of which 97% are in africa. the aim of this study was the determining of prevalence as well as the phylogeny of s. haematobium among school children in argungu emirate, kebbi state nigeria. a total of 325 urine samples was collected from school children between 7 to 14 years. s. heamatobium eggs was examined under dissecting microscope and dna was extracted from ... | 2017 | 28822206 |
schistosomiasis: drugs used and treatment strategies. | neglected tropical diseases (ntds) affect millions of people in different geographic regions, especially the poorest and most vulnerable. currently ntds are prevalent in 149 countries, seventeen of these neglected tropical parasitic diseases are classified as endemic. one of the most important of these diseases is schistosomiasis, also known as bilharzia, a disease caused by the genus schistosoma. it presents several species, such as schistosoma haematobium, schistosoma japonicum and schistosoma ... | 2017 | 28803725 |
the microbiome in urogenital schistosomiasis and induced bladder pathologies. | human schistosomiasis is a highly prevalent neglected tropical disease (ntd) caused by schistosoma species. research on the molecular mechanisms influencing the outcomes of bladder infection by schistosoma haematobium is urgently needed to develop new diagnostics, therapeutics and infection prevention strategies. the objective of the research study was to determine the microbiome features and changes in urine during urogenital schistosomiasis and induced bladder pathologies. | 2017 | 28793309 |
in vitro and in vivo activity of r- and s- praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel against schistosoma haematobium. | praziquantel (pzq) is the mainstay of schistosomiasis control and has been successfully used for decades. however, its mechanism of action is not fully understood. while the majority of studies have been conducted on schistosoma mansoni, it is not known which enantiomer, r- or s-praziquantel (r-/s-pzq), is responsible for the activity on schistosoma haematobium. | 2017 | 28764732 |
prevalence and seasonal transmission of schistosoma haematobium infection among school-aged children in kaedi town, southern mauritania. | mauritania is at the fringe of transmission of human schistosomiasis, which mainly occurs in the southern and southeastern parts of the country. this study aimed to assess the influence of rainfall seasonality on the prevalence of schistosoma haematobium infection among school-aged children in kaedi, southern mauritania. | 2017 | 28747222 |
schistosomiasis in european travelers and migrants: analysis of 14 years tropnet surveillance data. | schistosomiasis remains one of the most prevalent parasitic diseases worldwide and the infection is frequently found in travelers and migrants. the european network for tropical medicine and travel health conducted a sentinel surveillance study on imported schistosomiasis between 1997 and 2010. this report summarizes epidemiological and clinical data from 1,465 cases of imported schistosomiasis. direct pathogen detection and serology were the main diagnostic tools applied. of these, 486 (33%) ca ... | 2017 | 28722637 |
evaluation of a mobile phone-based microscope for screening of schistosoma haematobium infection in rural ghana. | abstractschistosomiasis affects over 170 million people in africa. here we compare a novel, low-cost mobile phone microscope to a conventional light microscope for the label-free diagnosis of schistosoma haematobium infections in a rural ghanaian school setting. we tested the performance of our handheld microscope using 60 slides that were randomly chosen from an ongoing epidemiologic study in school-aged children. the mobile phone microscope had a sensitivity of 72.1% (95% confidence interval [ ... | 2017 | 28719262 |
haematological profile and intensity of urogenital schistosomiasis in ghanaian children. | urogenital schistosomiasis is a widely contracted parasitic helminth infection often associated with haematological abnormalities. | 2017 | 28713432 |
ferrocenyl, ruthenocenyl, and benzyl oxamniquine derivatives with cross-species activity against schistosoma mansoni and schistosoma haematobium. | schistosomiasis is a parasitic disease that affects more than 250 million people annually, mostly children in poor, tropical, rural areas. only one treatment (praziquantel) is available, putting control efforts at risk should resistance occur. in pursuit of treatment alternatives, we derivatized an old antischistosomal agent, oxamniquine (oxa). four organometallic derivatives of oxa were synthesized and tested against schistosoma mansoni in vitro and in vivo. of these, a ferrocenyl derivative, 1 ... | 2017 | 28686009 |
variability of urine parameters in children infected with schistosoma haematobium in ukawu community, onicha local government area, ebonyi state, nigeria. | schistosomiasis, a chronic, debilitating and neglected tropical and sub-tropical water-borne ailment, is highly endemic in nigeria, especially among primary school children in rural communities. the study on the variability of urine parameters in children infected with schistosomahaematobium in ukawu community, onicha local government area of ebonyi state, was undertaken. | 2017 | 28670635 |
schistosoma haematobium: a delayed cause of hematuria. | a 22-year-old african american man with recurrent episodes of gross hematuria for 6 months presented to the clinic for evaluation. a thorough history revealed that the patient emigrated from mozambique to the united states 12 years ago. urine culture was negative for a urinary tract infection. cystoscopy revealed 4 lesions in the bladder. biopsy of the bladder lesion revealed severe cystitis and schistosoma haematobium. the patient later confirmed that he used to swim in rivers and streams back ... | 2017 | 28652164 |
high burden of schistosoma mansoni infection in school-aged children in marolambo district, madagascar. | a school-based survey was undertaken to assess prevalence and infection intensity of schistosomiasis in school-aged children in the marolambo district of madagascar. | 2017 | 28646926 |
schistosoma haematobium, a rare aetiology of spinal cord compression. | 2017 | 28637112 | |
prevalence and distribution of schistosoma haematobium infection among school children living in southwestern shores of lake malawi. | the prevalence of schistosoma haematobium infection has been shown to be about 23.7% among children living in the lakeshore areas of malawi, with reinfection rates of about 30% to 40%. this study aimed to determine the current prevalence and distribution of s. haematobium infection in school children along the southwestern shores of lake malawi and examine the control interventions present in the area. | 2017 | 28567191 |
the hidden epidemic of schistosomiasis in recent african immigrants and asylum seekers to italy. | the prevalence of schistosomiasis among recent refugees from sub-saharan africa in italy is unknown. this is a retrospective review of african immigrants screened at centre for tropical diseases of negrar from march 2014 to february 2016. of the 373 immigrants tested, 34% were positive at least at one schistosomiasis test. the proportion of positive elisa serology was 103/373 (27.6%). at microscopy, infected subjects were 65/373 (17.4%), (51% schistosoma haematobium, 38% schistosoma mansoni, 11% ... | 2017 | 28560535 |
comparison of the spatial patterns of schistosomiasis in zimbabwe at two points in time, spaced twenty-nine years apart: is climate variability of importance? | temperature, precipitation and humidity are known to be important factors for the development of schistosome parasites as well as their intermediate snail hosts. climate therefore plays an important role in determining the geographical distribution of schistosomiasis and it is expected that climate change will alter distribution and transmission patterns. reliable predictions of distribution changes and likely transmission scenarios are key to efficient schistosomiasis intervention-planning. how ... | 2017 | 28555471 |
epidemiology of urothelial carcinoma. | the epithelium lining is defined as the mucosal surfaces of the renal collecting tubules, calyces and pelvis, as well as the ureter, bladder and urethra. the term "urothelium" is used to refer to these surfaces. upper tract urothelial carcinoma is a rare subset of urothelial cancers with a poor prognosis. urinary bladder cancer is the most common malignancy involving the urinary system. upper tract urothelial carcinoma is more common in men than in women, with a male-to-female ratio of 2:1. the ... | 2017 | 28543959 |
dynamics of freshwater snails and schistosoma infection prevalence in schoolchildren during the construction and operation of a multipurpose dam in central côte d'ivoire. | the construction and operation of small multipurpose dams in africa have a history of altering the transmission of water-based diseases, including schistosomiasis. the current study was designed to investigate the abundance and dynamics of schistosomiasis intermediate host snails and schistosoma infections in humans during the construction and the first years of operation of a small multipurpose dam in côte d'ivoire. | 2017 | 28468667 |
effect of temperature on the bulinus globosus - schistosoma haematobium system. | given that increase in temperature may alter host-parasite relationships, the anticipated rise in temperature due to global warming might change transmission patterns of certain diseases. however, the extent to which this will happen is not well understood. | 2017 | 28457230 |
schistosoma mansoni cercarial elastase (smce): differences in immunogenic properties of native and recombinant forms. | the schistosoma mansoni cercarial elastase (smce) has previously been shown to be poorly immunogenic in mice. however, a minority of mice were able to produce antibodies against smce after multiple immunizations with crude preparations containing the enzyme. these mice were partially protected against challenge infections of s. mansoni. in the present study, we show that in contrast to the poor immunogenicity of the enzymatically active native form of smce derived from a crude preparation (cerca ... | 2017 | 28777067 |
point-of-care mobile digital microscopy and deep learning for the detection of soil-transmitted helminths and schistosoma haematobium. | microscopy remains the gold standard in the diagnosis of neglected tropical diseases. as resource limited, rural areas often lack laboratory equipment and trained personnel, new diagnostic techniques are needed. low-cost, point-of-care imaging devices show potential in the diagnosis of these diseases. novel, digital image analysis algorithms can be utilized to automate sample analysis. | 2017 | 28838305 |
prevalence of strongyloides stercoralis and other intestinal parasite infections in school children in a rural area of angola: a cross-sectional study. | strongyloides stercoralis is widely distributed in the tropics and subtropics. the aim of this study was to determine the prevalence of s. stercoralis and other intestinal parasites and identify the risk factors for infection with s. stercoralis in a rural area of angola. a cross-sectional study was conducted in school-age children (sac) in cubal, angola. a questionnaire collecting clinical and epidemiological variables was used, and two stool samples were collected. a concentration technique (r ... | 2017 | 28820707 |
genitourinary schistosomiasis: life cycle and radiologic-pathologic findings. | genitourinary schistosomiasis is produced by schistosoma haematobium, a species of fluke that is endemic to africa and the middle east, and causes substantial morbidity and mortality in those regions. it also may be seen elsewhere, as a result of travel or immigration. s haematobium, one of the five fluke species that account for most human cases of schistosomiasis, is the only species that infects the genitourinary system, where it may lead to a wide spectrum of clinical symptoms and signs. in ... | 2016 | 22786992 |
[comparative study of schistosomiasis transmission (urinary and intestinal forms) at 10 sites in burkina faso (in sub-saharan africa)]. | despite great progress in schistosomiasis control over the past decade in burkina faso, this disease remains a public health problem. this study analyzes parasitologic data from investigations of schistosoma haematobium, s. mansoni, and mollusks. the prevalence rate of s. haematobium varies from 3.3% to 50.4%; that for s. mansoni (tested only in the western part of the country) from 3.3% to 39.1%. prevalence rates are higher in school-aged boys than girls, but the reverse is true among adults. s ... | 2016 | 23174311 |
coinfection of schistosoma species with hepatitis b or hepatitis c viruses. | although a considerable number of studies have been undertaken to date, it is still controversial as to whether or not coinfection with schistosomiasis increases the susceptibility to or progression from hepatitis b virus (hbv) or hepatitis c virus (hcv) infection. this review is a closer examination of the key studies conducted on human populations on clinical factors that were published in english between 1975 and january 2015. our review is mainly based on tables containing the salient inform ... | 2016 | 27015949 |
ureteral obstruction caused by schistosomiasis. | we report a unusual case of hydro-ureteronephrosis caused by schistosomiasis in a 66-year-old female. computed tomography (ct) and biochemistry initially suggested a transitional cell carcinoma of the left proximal ureter. the patient was referred for reno-ureterectomy, but histopathological examination of the resection specimen demonstrated deposits of schistosoma haematobium eggs. although schistosomiasis is rare in western europe, this case illustrates the importance of considering infectious ... | 2016 | 24479290 |
unexpected urinary schistosoma infection in a belgian travel group returning from malawi. | urinary schistosomiasis, caused by schistosoma haematobium, is a prevalent parasitic infection in certain areas of africa and the middle east. humans can be infected by cercariae when they are in contact with contaminated freshwater. the adult worms reside in the veins of the vesical and pelvis plexuses. the urinary bladder, the seminal vesicles and the lower ends of the ureters are the most commonly affected organs. in this case report, we describe an unrecognised case of urinary schistosomiasi ... | 2016 | 24156230 |
[acute intestinal obstruction]. | a 12-year-old boy is admitted for emergency surgery for acute abdominal syndrome. the intervention showed strangulation of the terminal ileum by the vermiform appendix. the pathology analysis showed bilharzial appendicitis by schistosoma haematobium. the patient was treated with praziquantel. the literature is not plentiful on this subject. because protozoiasis is endemic in this area, it should be looked for in all cases of appendicitis, as it requires medical treatment in addition to the appen ... | 2016 | 24095806 |
[seasonal variability of intestinal helminths and schistosoma haematobium in a rural area of the sahel in mali]. | the objective of this study was to determine the prevalence of intestinal helminths and schistosoma haematobium before and after the rainy season in pongonon, mali. | 2016 | 23360644 |
identification of miracidia of schistosoma haematobium in a bladder wash sample. | 2016 | 26972707 | |
insight into the molecular basis of schistosoma haematobium-induced bladder cancer through urine proteomics. | infection due to schistosoma haematobium is carcinogenic. however, the cellular and molecular mechanisms underlying urogenital schistosomiasis (ugs)-induced carcinogenesis have not been well defined. conceptually, early molecular detection of this phenomenon, through non-invasive procedures, seems feasible and is desirable. previous analysis of urine collected during ugs suggests that estrogen metabolites, including depurinating adducts, may be useful for this purpose. here, a new direction was ... | 2016 | 26951512 |
[myeloradiculitis due to schistosoma haematobium: about an observation in dakar (senegal)]. | nervous localisations of schistosomiasis are rare. we report the case of a 25 year-old senegalese patient admitted for a progressive myeloradiculitis onset, over a one week period. the diagnosis of schistosoma haematobium myeloradiculitis was made in front of a positive serum serology for s. haematobium, presence of s. haematobium eggs in urine, hyperproteinorachia, endemicity of s. haematobium in the region where the patient was originating and a past medical history of macroscopic hematuria in ... | 2016 | 26936766 |
schistosomiasis elimination by 2020 or 2030? | schistosomiasis has been a public health burden in a number of countries across the globe for centuries and probably beyond. the world health organization and partners are currently preparing to move towards elimination of this disease. however, given the historical challenges and barriers to ridding areas of this water-borne parasite infection, we question whether the current targets for eliminating schistosomiasis as a global health problem can be achieved. | 2016 | 26907938 |
early detection of schistosoma egg-induced pulmonary granulomas in a returning traveler. | we report the case of a french traveler who developed acute pulmonary schistosomiasis 2 months after visiting benin. he presented with a 1-month history of fever, cough, and thoracic pain. initial investigations revealed hypereosinophilia and multiple nodular lesions on chest computed tomography scan. lung biopsies were performed 2 months later because of migrating chest infiltrates and increasing eosinophilia. histological examination showed schistosomal egg-induced pulmonary granulomas with ov ... | 2016 | 26787142 |
schistosomiasis in school-age children in burkina faso after a decade of preventive chemotherapy. | to assess the impact of a decade of biennial mass administration of praziquantel on schistosomiasis in school-age children in burkina faso. | 2016 | 26769995 |
evidence for a permanent presence of schistosomiasis in corsica, france, 2015. | we present a case of acute schistosomiasis acquired in corsica after bathing in the cavu river during the summer of 2015. the diagnosis was made following epidemiological, laboratory and serological assessments. after a previous outbreak of urogenital schistosomiasis during the summer of 2013, when more than 120 infections were diagnosed, this further case indicates transmission was still effective in 2015, thus suggesting a permanent presence of schistosomiasis in corsica. | 2016 | 26767427 |
schistosoma haematobium in guinea-bissau: unacknowledged morbidity due to a particularly neglected parasite in a particularly neglected country. | schistosomiasis is the major neglected tropical helminthic disease worldwide. current knowledge on the epidemiology of schistosomiasis in guinea-bissau is scarce and regarding to the absence of schistosoma haematobium (s.h.). therefore, a pilot study was undertaken to assess the prevalence and morbidity due to s.h. infection in randomly selected 90 children and adolescents aged 6 to 15 years. prevalence of s.h. infection was 20.00 % (18/90). microhematuria was observed in 61.11 % (11/18) of s.h. ... | 2016 | 26755362 |
praziquantel coverage in schools and communities targeted for the elimination of urogenital schistosomiasis in zanzibar: a cross-sectional survey. | biannual mass drug administration (mda) with praziquantel and additional interventions to eliminate urogenital schistosomiasis has been implemented on the zanzibar islands, united republic of tanzania, since 2012. we aimed to assess the coverage of school-based treatment (sbt) and community-wide treatment (cwt), to validate the coverage reported by the zanzibar ministry of health (moh) and to identify reasons for non-compliance. | 2016 | 26727915 |
advancing a vaccine to prevent human schistosomiasis. | several candidate human schistosomiasis vaccines are in different stages of preclinical and clinical development. the major targets are schistosoma haematobium (urogenitial schistosomiasis) and schistosoma mansoni (intestinal schistosomiasis) that account for 99% of the world's 252 million cases, with 90% of these cases in africa. two recombinant s. mansoni vaccines - sm-tsp-2 and sm-14 are in phase 1 trials, while smp80 (calpain) is undergoing testing in non-human primates. sh28gst, also known ... | 2016 | 27036511 |
computational deconvolution of gene expression by individual host cellular subsets from microarray analyses of complex, parasite-infected whole tissues. | analyses of whole organs from parasite-infected animals can reveal the entirety of the host tissue transcriptome, but conventional approaches make it difficult to dissect out the contributions of individual cellular subsets to observed gene expression. computational deconvolution of gene expression data may be one solution to this problem. we tested this potential solution by deconvoluting whole bladder gene expression microarray data derived from a model of experimental urogenital schistosomias ... | 2016 | 27025770 |
risk factors and micro-geographical heterogeneity of schistosoma haematobium in ndumo area, umkhanyakude district, kwazulu-natal, south africa. | schistosomiasis is a snail-transmitted parasitic disease endemic in most rural areas of sub-saharan africa. however, the currently used prediction models fail to capture the focal nature of its transmission due to the macro-geographical levels considered and paucity of data at local levels. this study determined the spatial distribution of schistosoma haematobium and related risk factors in ndumo area, umkhanyakude district, kwazulu-natal province in south africa. a sample of 435 schoolchildren ... | 2016 | 27012720 |
anti-schistosoma igg responses in schistosoma haematobium single and concomitant infection with malaria parasites. | areas prone to schistosomiasis are also at risk of malaria transmission. the interaction between the causal agents of the two diseases could modulate immune responses tailored toward protecting or aggravating morbidity dynamics and impair schistosoma diagnostic precision. this study aimed at assessing the effect of plasmodium spp. in concomitant infection with schistosoma haematobium in modulation of anti-schistosoma igg antibodies. the school-based cross-sectional study recruited a total of 322 ... | 2016 | 27092873 |
a mixed-methods approach to understanding water use and water infrastructure in a schistosomiasis-endemic community: case study of asamama, ghana. | surface water contaminated with human waste may transmit urogenital schistosomiasis (ugs). water-related activities that allow skin exposure place people at risk, but public health practitioners know little about why some communities with access to improved water infrastructure have substantial surface water contact with infectious water bodies. community-based mixed-methods research can provide critical information about water use and water infrastructure improvements. | 2016 | 27076042 |
schistosomiasis transmission; socio-demographic, knowledge and practices as transmission risk factors in pregnant women. | schistosoma transmission is influenced by the interplay between various factors ranging from parasite to host associated factors. while many studies have focused on mass chemotherapy to reduce transmission in other populations, no study has examined the impact of social factors that favour transmission in pregnant women in nigeria. the study was conducted to assess the impact of knowledge, attitudes and sociodemographic factors on schistosomiasis burden in pregnant women of rural communities of ... | 2016 | 27065605 |
development of a schistosomiasis vaccine. | schistosomiasis is a neglected tropical disease (ntd) of public health importance. despite decades of implementation of mass praziquantel therapy programs and other control measures, schistosomiasis has not been contained and continues to spread to new geographic areas. a schistosomiasis vaccine could play an important role as part of a multifaceted control approach. with regards to vaccine development, many biological bottlenecks still exist: the lack of reliable surrogates of protection in hum ... | 2016 | 26651503 |
elimination of urogenital schistosomiasis in iran: past history and the current situation. | in recent years, through a national programme for schistosomiasis control, this infection has been eliminated from iran. the aim of this study was to report the process of significant decrease of urogenital schistosomiasis in southwestern iran. during national programme surveillance for urogenital schistosomiasis control which was implemented by centres for disease control and prevention (cdc) of khuzestan province from 1975 to 2013, more than 1·3 million urine samples were taken from inhabitant ... | 2016 | 27279000 |
schistosoma haematobium infection, health and nutritional status in school-age children in a rural setting in northern senegal. | the aim of this study was to investigate the occurrence of urinary schistosomiasis in school children in a rural village of northern senegal, and to evaluate the impact of this parasitic infection on children's health, growth, and nutritional status. | 2016 | 27277202 |
population genetic structure of the freshwater snail, bulinus globosus, (gastropoda: planorbidae) from selected habitats of kwazulu-natal, south africa. | the freshwater snail bulinus globosus is an important intermediate host of schistosoma haematobium, the causative agent of urinary schistosomiasis. this disease is of major health concern, especially in africa where the majority of cases have been reported. in this study the inter- and intra-genetic diversity and population genetic structure of b. globosus from nine locations in the kwazulu-natal province of south africa was studied using four polymorphic microsatellite loci (bgz1-bgz4). moderat ... | 2016 | 27267152 |
gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five african countries. | the schistosomiasis consortium for operational research and evaluation (score) was established in 2008 to answer strategic questions about schistosomiasis control. for programme managers, a high-priority question is: what are the most cost-effective strategies for delivering preventive chemotherapy (pct) with praziquantel (pzq)? this paper describes the process score used to transform this question into a harmonized research protocol, the study design for answering this question, the village eli ... | 2016 | 27230666 |
ultrasonography of gallbladder abnormalities due to schistosomiasis. | after malaria, schistosomiasis remains the most important tropical parasitic disease in large parts of the world. schistosomiasis has recently re-emerged in southern europe. intestinal schistosomiasis is caused by most schistosoma (s.) spp. pathogenic to humans and leads to chronic inflammation and fibrosis of the colon as well as to liver fibrosis. gallbladder abnormalities usually occur in patients with advanced hepatic portal fibrosis due to schistosoma mansoni infection. occasionally, gallbl ... | 2016 | 27169865 |
cervical cytology as a diagnostic tool for female genital schistosomiasis: correlation to cervical atypia and schistosoma polymerase chain reaction. | female genital schistosomiasis (fgs) is a tissue reaction to lodged ova of schistosoma haematobium in the genital mucosa. lesions can make the mucosa friable and prone to bleeding and discharge. women with fgs may have an increased risk of hiv acquisition, and fgs may act as a cofactor in the development of cervical cancer. | 2016 | 27168759 |
cholinergic components of nervous system of schistosoma mansoni and s. haematobium (digenea: schistosomatidae). | a comparison has been made for the first time between the cholinergic components of the nervous system of important human digeneans namely schistosoma mansoni and schistosoma haematobium from infected hamster (cricentus auratus) in egypt. in each parasite, the central nervous system consists of two cerebral ganglia and three pairs of nerve cords (ventral, lateral, and dorsal) linked together by some transverse connectives and numerous ring commissures. peripheral cholinergic innervation was dete ... | 2016 | 27130318 |
a microfiltration device for urogenital schistosomiasis diagnostics. | schistosomiasis is a parasitic disease affecting over 200 million people worldwide. this study reports the design and development of a microfiltration device for isolating schistosome eggs in urine for rapid diagnostics of urogenital schistosomiasis. the design of the device comprises a linear array of microfluidic traps to immobilize and separate schistosome eggs. sequential loading of individual eggs is achieved autonomously by flow resistance, which facilitates observation and enumeration of ... | 2016 | 27124499 |
modelling the spatial and seasonal distribution of suitable habitats of schistosomiasis intermediate host snails using maxent in ndumo area, kwazulu-natal province, south africa. | schistosomiasis is a snail-borne disease endemic in sub-saharan africa transmitted by freshwater snails. the distribution of schistosomiasis coincides with that of the intermediate hosts as determined by climatic and environmental factors. the aim of this paper was to model the spatial and seasonal distribution of suitable habitats for bulinus globosus and biomphalaria pfeifferi snail species (intermediate hosts for schistosoma haematobium and schistosoma mansoni, respectively) in the ndumo area ... | 2016 | 27814746 |
incidental pseudolymphomatous bladder inflammatory polyp revealing urinary schistosomiasis. | a 25-year-old female who had returned from a trip to madagascar that was not reported, underwent an endoscopic bladder polyp resection. histopathology examination revealed an intense pseudolymphomatous inflammatory polyp caused by a schistosoma infection. bladder polyps due to schistosomiasis represent a rare condition in developed countries and have to be ruled out in the case of any intense unexplained inflammation. | 2016 | 27810520 |
a case report of schistosoma haematobium infection in a pregnant migrant raises concerns about lack of screening policies. | pregnant women with urinary schistosomiasis should be treated, but screening is not implemented in migrants. we report herein a case of a migrant diagnosed late into pregnancy, after diagnosis was made in her husband. praziquantel was safe and effective. schistosomiasis should be considered in pregnant women from endemic countries. | 2016 | 27799503 |
in vitro schistosomicidal activity of phytol and tegumental alterations induced in juvenile and adult stages of schistosoma haematobium. | there is renewed interest in natural products as a starting point for discovery of drugs for schistosomiasis. recent studies have shown that phytol reveals interesting in vivo and in vitro antischistosomal properties against schistosoma mansoni adult worms. here, we report the in vitro antischistosomal activity of phytol against schistosoma haematobium juvenile and adult worms and alterations on the tegumental surface of the worms by means of scanning electron microscopy. the assay, which was ca ... | 2016 | 27658600 |
[blødning per rectum hos en patient med schistosoma haematobium-infektion]. | 2016 | 27649585 | |
efficacy and safety of moxidectin, synriam, synriam-praziquantel versus praziquantel against schistosoma haematobium and s. mansoni infections: a randomized, exploratory phase 2 trial. | schistosomiasis affects millions of people, yet treatment options are limited. the antimalarial synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or clinical studies. | 2016 | 27636542 |
detection of urinary tract pathology in some schistosoma haematobium infected nigerian adults. | screening for schistosoma haematobium infection and its possible morbidity was carried out in 257 adult participants in eggua community, ogun state, nigeria. parasitological assessment for the presence of ova of s. haematobium in urine and abdominopelvic ultrasonographic examination for bladder and secondary kidney pathology were carried out. s. haematobium prevalence of 25.68% (66/257) was recorded among the participants. there was a significantly higher prevalence of 69.2% of urinary schistoso ... | 2016 | 27635146 |
comparative assessment of health benefits of praziquantel treatment of urogenital schistosomiasis in preschool and primary school-aged children. | schistosomiasis is a major public health problem in africa. however, it is only recently that its burden has become recognised as a significant component impacting on the health and development of preschool-aged children. a longitudinal study was conducted in zimbabwean children to determine the effect of single praziquantel treatment on schistosoma haematobium-related morbidity markers: microhaematuria, proteinuria, and albuminuria. changes in these indicators were compared in 1-5 years versus ... | 2016 | 27631011 |
epidemiological and clinical aspects of urogenital schistosomiasis in women, in burkina faso, west africa. | because infections with schistosoma haematobium usually peak in childhood, the majority of studies on schistosomiasis have focused on school-aged children. this study aimed to assess the epidemiological and clinical aspects of urogenital schistosomiasis in women in burkina faso, west africa. | 2016 | 27581074 |
minimising invasiveness in diagnostics: developing a rapid urine-based monoclonal antibody dipstick test for malaria. | to generate monoclonal antibodies (mabs) for developing a rapid malaria diagnostic urine-based assay (rubda), using plasmodium-infected human urinary antigens. | 2016 | 27546068 |
increasing the reach: involving local muslim religious teachers in a behavioral intervention to eliminate urogenital schistosomiasis in zanzibar. | in zanzibar, united republic of tanzania, madrassa schools are influential institutions, where children and adults can learn about the interpretation of the koran. we aimed to explore the involvement of madrassa teachers for behavior change interventions in a randomized operational research trial designed to investigate the impact of multiple approaches to eliminate urogenital schistosomiasis transmission from zanzibar. madrassa teachers performing in the 30 communities of the behavior change st ... | 2016 | 27498244 |
the role of climate on prevalence or eradication of vesical schistosomiasis in khuzestan province of iran. | climate is defined as the combination of climate and air elements of a given region which is usually measured for a period of decades. de-marton climate classification has been established based on many factors, including elements such as temperature and rainfall. vesicle schistosomiasis is a parasitic disease caused by schistosoma haematobium. this parasite lives in the blood vessels of the bladder. the parasite can cause hematuria in human and if not treated properly can lead to vesicale carci ... | 2016 | 27413310 |
urogenital schistosomiasis transmission on unguja island, zanzibar: characterisation of persistent hot-spots. | elimination of urogenital schistosomiasis transmission is a priority for the zanzibar ministry of health. preventative chemotherapy together with additional control interventions have successfully alleviated much of the disease burden. however, a persistently high schistosoma haematobium prevalence is found in certain areas. our aim was to characterise and evaluate these persistent "hot-spots" of transmission and reinfection in comparison with low-prevalence areas, to support the intervention pl ... | 2016 | 27986092 |