Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| high prevalence of curable sexually transmitted infections among pregnant women in a rural county hospital in kilifi, kenya. | women attending antenatal care (anc) in resource-limited countries are frequently screened for syphilis and hiv, but rarely for other sexually transmitted infections (stis). we assessed the prevalence of curable stis, defined as infection with either chlamydia trachomatis or neisseria gonorrhoeae or trichomonas vaginalis, from july to september 2015. | 2017 | 28362869 |
| high hiv prevalence and incidence among women in southern mozambique: evidence from the mdp microbicide feasibility study. | the study aimed to assess the feasibility of conducting large scale hiv prevention clinical trials in mozambique by measuring hiv prevalence and incidence among women of reproductive age. this paper describes the baseline socio-demographic characteristics of the mozambique microbicides development programme (mdp) feasibility cohort, baseline prevalence of hiv and other stis, and hiv incidence. | 2017 | 28350843 |
| routine testing of mycoplasma genitalium and trichomonas vaginalis. | mycoplasma genitalium (mg) and trichomonas vaginalis (tv) are common sexual transmitted infections (sti). however, most sti screening programmes do not include routinely detection of these pathogens. consequently, epidemiological data about mg and tv in the general population is lacking. the current study aims to give insight into the prevalence of both infections, thereby guiding decisions whether testing for these pathogens should be included routinely. | 2017 | 28301989 |
| survey of sexually transmitted disease laboratory methods in u.s. army laboratories, 2012. | sexually transmitted diseases (std) affect primarily young people (17-24 years). the u.s. military, with many young people, strives to maintain effective std treatment and prevention programs using current methods. laboratory testing technology and capacity are important for appropriate clinical management and to provide data to direct prevention programs. std laboratory capabilities are assessed in civilian and military laboratories using surveys. an army laboratory survey was conducted in 2007 ... | 2017 | 28290950 |
| point-of-care sexually transmitted infection diagnostics: proceedings of the star sexually transmitted infection-clinical trial group programmatic meeting. | the goal of the point-of-care (poc) sexually transmitted infection (sti) diagnostics meeting was to review the state-of-the-art research and develop recommendations for the use of poc sti diagnostics. experts from academia, government, nonprofit, and industry discussed poc diagnostics for stis such as chlamydia trachomatis, human papillomavirus, neisseria gonorrhoeae, trichomonas vaginalis, and treponema pallidum. key objectives included a review of current and emerging technologies, clinical an ... | 2017 | 28282646 |
| simultaneous detection and identification of sti pathogens by multiplex real-time pcr in genital tract specimens in a selected area of apulia, a region of southern italy. | genital tract infections are globally a major cause of morbidity in sexually active individuals. the aim of this study was to investigate the prevalence and associations of co-infections of chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis, mycoplasma hominis (mh), mycoplasma genitalium, ureaplasma urealyticum (uu) and ureaplasma parvum (up) in specimens collected from female (sf) and male (sm) patients. | 2017 | 28260146 |
| diagnosis of some genital-tract infections: part 1. an historical perspective. | making a prompt and accurate diagnosis of genital tract infections is the key to instituting appropriate treatment and the linchpin of sexually transmitted infection control. we present a brief history, not covering syphilis, of diagnostic events for each of six bacteria and one protozoan from the time of discovery up to the molecular revolution. the latter is touched upon but its impact will form the substance of a further presentation. here, hindsight is helpful in understanding the way in whi ... | 2017 | 28186463 |
| a review of expedited partner therapy for the management of sexually transmitted infections in adolescents. | adolescents are at high risk of acquiring and becoming reinfected with sexually transmitted infections. partner notification and treatment are essential to preventing the spread of sexually transmitted infections. expedited partner therapy (ept) is a method of partner treatment used by medical providers to treat patients' sexual partners without direct medical evaluation or counseling. the objective of this article is to review the current literature regarding ept effectiveness, patients' attitu ... | 2017 | 28167140 |
| partner notification and treatment for sexually transmitted infections among pregnant women in gaborone, botswana. | chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), and trichomonas vaginalis (tv) are sexually transmitted infections (stis) associated with adverse birth outcomes. untreated partners contribute to high rates of sti reinfection; thus, partner notification and treatment remain important components of sti care and control. a prospective cohort study was conducted among 300 pregnant women presenting to the antenatal clinic at princess marina hospital in gaborone, botswana who enrolled in an st ... | 2017 | 28166698 |
| impact of deploying multiple point-of-care tests with a 'sample first' approach on a sexual health clinical care pathway. a service evaluation. | to assess clinical service value of sti point-of-care test (poct) use in a 'sample first' clinical pathway (patients providing samples on arrival at clinic, before clinician consultation). specific outcomes were: patient acceptability; whether a rapid nucleic acid amplification test (naat) for chlamydia trachomatis/neisseria gonorrhoeae (ct/ng) could be used as a poct in practice; feasibility of non-naat poct implementation for trichomonas vaginalis (tv) and bacterial vaginosis (bv); impact on p ... | 2017 | 28159916 |
| chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis screening and treatment of pregnant women in port-au-prince, haiti. | in haiti, routine screening for chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), and trichomonas vaginalis (tv) among pregnant women is not conducted; yet these sexually transmitted infections (stis) are associated with adverse birth and newborn health outcomes. we aimed to assess the acceptability and feasibility of screening and the prevalence of stis among pregnant women in port-au-prince, haiti. pregnant women of at least 18 years of age who attend haitian study group for kaposi's sar ... | 2017 | 28134005 |
| costing of national sti program implementation for the global sti control strategy for the health sector, 2016-2021. | in 2016 the world health assembly adopted the global strategy on sexually transmitted infections (sti) 2016-2021 aiming to reduce curable stis by 90% by 2030. we costed scaling-up priority interventions to coverage targets. | 2017 | 28129372 |
| an evaluation study of the becton-dickinson probetec qx (bdqx) trichomonas vaginalis trichomoniasis molecular diagnostic test in two large, urban std services. | the bashh guidelines recommend molecular tests to aid diagnosis of trichomonas vaginalis (tv) infection; however many clinics continue to use relatively insensitive techniques (ph, wet-prep microscopy (wpm) and culture). our objectives were to establish a laboratory pathway for tv testing with the becton-dickinson qx (bdqx) molecular assay, to determine tv prevalence and to identify variables associated with tv detection. | 2017 | 28108699 |
| topical tenofovir protects against vaginal simian hiv infection in macaques coinfected with chlamydia trachomatis and trichomonas vaginalis. | chlamydia trachomatis and trichomonas vaginalis, two prevalent sexually transmitted infections, are known to increase hiv risk in women and could potentially diminish preexposure prophylaxis efficacy, particularly for topical interventions that rely on local protection. we investigated in macaques whether coinfection with chlamydia trachomatis/trichomonas vaginalis reduces protection by vaginal tenofovir (tfv) gel. | 2017 | 28060011 |
| sexually transmitted diseases and infertility. | female infertility, including tubal factor infertility, is a major public health concern worldwide. most cases of tubal factor infertility are attributable to untreated sexually transmitted diseases that ascend along the reproductive tract and are capable of causing tubal inflammation, damage, and scarring. evidence has consistently demonstrated the effects of chlamydia trachomatis and neisseria gonorrhoeae as pathogenic bacteria involved in reproductive tract morbidities including tubal factor ... | 2017 | 28007229 |
| quantitative real-time polymerase chain reaction for the diagnosis of mycoplasma genitalium infection in south african men with and without symptoms of urethritis. | this study was done to diagnose mycoplasma genitalium infection based on bacterial load in urine specimens from symptomatic and asymptomatic men. | 2017 | 27898565 |
| mycoplasma genitalium and trichomonas vaginalis in france: a point prevalence study in people screened for sexually transmitted diseases. | mycoplasma genitalium and trichomonas vaginalis are common causes of sexually transmitted infections, but limited prevalence data are available in france. we aimed to evaluate the prevalence of m. genitalium and t. vaginalis infections and to assess prevalence by gender, age, sample collection sites and clinical symptoms. a multicentre collection of specimens was intended to obtain a nationwide overview of the epidemiology. | 2017 | 27836808 |
| combined testing for chlamydia, gonorrhea, and trichomonas by use of the bd max ct/gc/tv assay with genitourinary specimen types. | the bd max ct/gc/tv (max) assay is a true multiplex assay for simultaneous detection of chlamydia (ct), gonorrhea (gc), and trichomonas (tv). we evaluated assay performance for women using endocervical and vaginal swabs as well as urine specimens. a total of 1,143 women were tested for ct, gc, and tv and, subsequently, another 847 (1,990 total women) for ct and gc only, with positivity rates for ct, gc, and tv of 7.1%, 2.3%, and 13.5%, respectively. in men, the performance for ct and gc was dete ... | 2017 | 27795343 |
| budgetary impact of compliance with sti screening guidelines in persons living with hiv. | the 2015 centers for disease control sexually transmitted diseases treatment guidelines recommend annual screening of all people living with hiv (plwh) for neisseria gonorrhoeae, chlamydia trachomatis, and syphilis; annual trichomonas vaginalis screening is recommended for hiv-infected women. the study objective was to evaluate the budgetary impact of sexually transmitted infection (sti) screening. we hypothesized that recommended sti screening is costly and would not be covered in full by insur ... | 2017 | 27787348 |
| expansion of comprehensive screening of male sexually transmitted infection clinic attendees with mycoplasma genitalium and trichomonas vaginalis molecular assessment: a retrospective analysis. | of 1,493 encounters of males at a sexually transmitted infection (sti) clinic in a community with a high prevalence of sti, chlamydia trachomatis was detected in 8.7% and neisseria gonorrhoeae was detected in 6.6%. additional trichomonas vaginalis and mycoplasma genitalium screening found 17.4% and 23.9% of the encounters, respectively, to be positive for sti. sti agents were detected in 13.7% of urine specimens; addition of pharyngeal and rectal collections to the analysis resulted in detection ... | 2017 | 27629896 |
| ureaplasma urealyticum: presence among sexually transmitted diseases. | the aim of this study was to detect the presence of chlamydia trachomatis, neisseria gonorrhoeae, mycoplasma genitalium, mycoplasma hominis, trichomonas vaginalis, and ureaplasma urealyticum in genital specimens of symptomatic patients. this study also examined the role of u. urealyticum in infections of the lower genital tract. cervical and urethral samples from 96 patients (46 males, 50 females) were tested using the seeplex((®)) std6 ace kit. consent forms were received and a questionnaire wa ... | 2017 | 27000449 |
| prevalence of mycoplasma genitalium in men with urethritis and in high risk asymptomatic males in tel aviv: a prospective study. | we sought to investigate the prevalence of mycoplasma genitalium, chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis in men presenting to a sexually transmitted infection (sti) clinic, with special attention to m. genitalium, its occurrence in israeli patients, coinfections, and risk factors. in a cross-sectional study, 259 men were successively enrolled in the tel aviv levinsky clinic for stis between november 2008 and november 2010. there were 118 men with urethritis and 1 ... | 2017 | 26826161 |
| cervicitis: a prospective observational study of empiric azithromycin treatment in women with cervicitis and non-specific cervicitis. | treatment with 1 g azithromycin was observed prospectively in 130 women with cervicitis (>30 polymorphonuclear leucocytes/high-powered field) enrolled in a cervicitis aetiology study of 558 women at three sexually transmitted infection clinics in sydney, australia. two overlapping groups of women with cervicitis were considered: 'cervicitis group 1' (n = 116) excluded women with trichomonas vaginalis and a subgroup of this, 'cervicitis group 2' (non-specific cervicitis) (n = 96) further excluded ... | 2017 | 26792283 |
| the prevalence of causative organisms of community-acquired urethritis in an age group at high risk for sexually transmitted infections in korean soldiers. | this study was designed to evaluate the causative organisms in young male soldiers with clinical signs and symptoms after sexual contact that suggests a diagnosis of urethritis. | 2017 | 26607860 |
| mycoplasmateceae species are not found in fallopian tubes of women with tubo-peritoneal infertility. | the role of mycoplasmas on the development and sequelae of pelvic inflammatory disease remains controversial. the objective of the present study is to correlate directly the presence of mycoplasmateceae through polimerase chain reaction (pcr) determinations in cervix and fallopian tubes of infertile patients with tubo-peritoneal factor diagnosed through laparoscopy. | 2017 | 22729196 |
| iron responsive-like elements in the parasite entamoeba histolytica. | in entamoeba histolytica, iron modulates virulence and gene expression via unknown regulatory mechanisms. the existence of a posttranscriptional iron regulatory system parallel to the ire/irp (iron-responsive element/iron regulatory protein) system in the protozoan trichomonas vaginalis has recently been reported. due to their evolutionary closeness and the importance of iron for growth and virulence in these protozoa, we hypothesized the existence of an ire/irp-like mechanism in e. histolytica. ... | 2017 | 28100304 |
| epitopes within recombinant α-actinin protein is serodiagnostic target for trichomonas vaginalis sexually transmitted infections. | to date there is no commercially-available serodiagnostic for women and men infected with trichomonas vaginalis. thirteen epitopes of the immunogenic t. vaginalis α-actinin (106.2-kda) are detected by sera of women patients, and 5 epitopes, a subset of the 13, are detected by sera of men. a truncated recombinant protein called act-p2 (63.5-kda) encoding the 5 epitopes is used for screening by elisa for antibody in sera of women and men. because act-p2 is poorly expressed in e. coli, we wanted al ... | 2017 | 28203642 |
| [nonviral sexually transmitted infections-epidemiology, clinical manifestations, diagnostic workup, therapy : part 3: treponemes, gardnerella and trichomonads]. | in germany, the reported syphilis prevalence has increased continuously since 2010, with a total of 6834 syphilis cases being reported in 2015. the largest increase of reported syphilis occurred in men who have sex with men (msm). the antibiotic agent of choice for treatment of syphilis is still penicillin. there are no penicillin-resistant treponema pallidum strains. alternatives are ceftriaxone and doxycycline. in germany, azithromycin is not approved for treatment of syphilis; however, therap ... | 2017 | 28058468 |
| transcriptomics indicates active and passive metronidazole resistance mechanisms in three seminal giardia lines. | giardia duodenalis is an intestinal parasite that causes 200-300 million episodes of diarrhoea annually. metronidazole (mtz) is a front-line anti-giardial, but treatment failure is common and clinical resistance has been demonstrated. mtz is thought to be activated within the parasite by oxidoreductase enzymes, and to kill by causing oxidative damage. in g. duodenalis, mtz resistance involves active and passive mechanisms. relatively low activity of iron-sulfur binding proteins, namely pyruvate: ... | 2017 | 28367140 |
| single-dose compared with multidose metronidazole for the treatment of trichomoniasis in women: a meta-analysis. | trichomonas vaginalis is the most common curable sexually transmitted infection worldwide. although the centers for disease control and prevention and the world health organization recommend a single 2-g dose of metronidazole for the first line of treatment for t. vaginalis among human immunodeficiency virus (hiv) negative women, high rates of repeat infections are found. the purpose of this meta-analysis was to compare treatment failure between single versus multidose metronidazole for the trea ... | 2017 | 27898571 |
| vaginal infections of albanian women infected with hpv and their impact in intraepithelial cervical lesions evidenced by pap test. | cervical cytology is the best single method for large screening of the population in identifying precancerous lesions of the uterine cervix. | 2017 | 28182076 |
| association between high risk human papillomavirus infection and co-infection with candida spp. and trichomonas vaginalis in women with cervical premalignant and malignant lesions. | human papillomavirus (hpv) is the necessary cause of cervical cancer. cervico-vaginal infection with pathogens like chlamydia is a likely cofactor. the interactions between hpv, trichomonas vaginalis (tv) and candida spp. are less understood, though inflammation induced by these pathogens has been demonstrated to facilitate oncogenesis. | 2017 | 27992790 |
| frequency of human immunodeficiency virus (hiv) in trichomonas vaginalis infected women in badagry, lagos, nigeria. | the interaction between hiv and trichomonas vaginalis infection has been widely studied in most developed countries but with scanty information in sub-saharan africa. while many of these studies have examined the prevalence of t. vaginalis infection in hiv positive individuals, no study in nigeria has shown the effect of t. vaginalis on hiv transmission. therefore, the study aimed to determine the occurrence of hiv in t. vaginalis infected women. | 2017 | 26962485 |
| the anti-trichomonas vaginalis phloroglucinol derivative isoaustrobrasilol b modulates extracellular nucleotides hydrolysis. | trichomonas vaginalis causes trichomoniasis, a neglected sexually transmitted disease. due to severe health consequences and treatment failure, new therapeutic alternatives are crucial. phloroglucinols from southern brazilian hypericum species demonstrated anti-t. vaginalis and anti-leishmania amazonensis activities. the modulation of biochemical pathways involved in the control of inflammatory response by ectonucleotidases, ntpdase and ecto-5'-nucleotidase, represents new targets for combating ... | 2017 | 28390095 |
| clinical laboratory assessments for mycoplasma genitalium in a high-prevalence sexually-transmitted infection community reveal epidemiologic dichotomies with trichomonas vaginalis. | mycoplasma genitalium is an emerging agent of sexually-transmitted infection and is responsible for clinically-significant genital tract disease in both females and males. similar to scenarios recently experienced with the urogenital flagellate trichomonas vaginalis, an evolving molecular diagnostic reference standard based on transcription-mediated amplification allows for accurate detection of the organism, plus additional insight into disease epidemiology. areas covered. the basis for this ar ... | 2017 | 27894204 |
| trichomonas vaginalis infection in symbiosis with trichomonasvirus and mycoplasma. | trichomonas vaginalis is a protozoan with an extracellular obligatory parasitic lifestyle exclusively adapted to the human urogenital tract and responsible for nearly a quarter billion sexually transmitted infections worldwide each year. this review focuses on symbiotic trichomonasvirus and mycoplasma carried by the protozoan, their molecular features and their role in altering the human vaginal microbiome and the immunopathogenicity of the parasite. improved diagnostics and larger clinical inte ... | 2017 | 28366838 |
| association between preterm labor and genitourinary tract infections caused by trichomonas vaginalis, mycoplasma hominis, gram-negative bacilli, and coryneforms. | preterm labor (ptl) is responsible for most cases of neonatal death. in most of these cases, the causes of ptl have not been established although several risk factors have been described. therefore, the aim of this study was to investigate risk factors for ptl before 37 gestational weeks among egyptian women. | 2017 | 28094234 |
| characterization of cyclin-dependent kinases and cdc2/cdc28 kinase subunits in trichomonas vaginalis. | cyclin-dependent kinases (cdks) have important roles in regulating key checkpoints between stages of the cell cycle. their activity is tightly regulated through a variety of mechanisms, including through binding with cyclin proteins and the cdc2/cdc28 kinase subunit (cks), and their phosphorylation at specific amino acids. studies of the components involved in cell cycle control in parasitic protozoa are limited. trichomonas vaginalis is the causative agent of trichomoniasis in humans and is the ... | 2017 | 27928981 |
| a cross-sectional analysis of trichomonas vaginalis infection among heterosexual hiv-1 serodiscordant african couples. | trichomonas vaginalis is the most prevalent curable sti worldwide and has been associated with adverse health outcomes and increased hiv-1 transmission risk. we conducted a cross-sectional analysis among couples to assess how characteristics of both individuals in sexual partnerships are associated with the prevalence of male and female t. vaginalis infection. | 2017 | 28377421 |
| the costa of trichomonads: a complex macromolecular cytoskeleton structure made of uncommon proteins. | the costa is a prominent striated fiber that is found in protozoa of the trichomonadidae family that present an undulating membrane. it is composed primarily of proteins that have not yet been explored. in this study, we used cell fractionation to obtain a highly enriched costa fraction whose structure and composition was further analyzed by electron microscopy and mass spectrometry. | 2017 | 28369980 |
| prevalence of trichomonas vaginalis in women of reproductive age at a family health clinic. | trichomonas vaginalis is considered the most prevalent curable sexually transmitted infection, and its occurrence exceeds that of gonococcal and chlamydia infections. this parasite has been identified as responsible for the increased risk of transmission of hiv and has also been associated with prostate and cervical cancer. many carriers of t. vaginalis are asymptomatic and, when experiencing a health problem, they most often have nonspecific symptoms. the aim of this research was to estimate th ... | 2017 | 28368862 |
| the prevalence of trichomoniasis and associated factors among women treated at a university hospital in southern brazil. | trichomoniasis is the most prevalent non-viral sexually transmitted disease (std) in the world; however, it remains a neglected parasitic disease. this study aimed to determine the prevalence of trichomoniasis and its associated epidemiological factors among women treated at a hospital in southern brazil. | 2017 | 28346531 |
| epigenome mapping highlights chromatin-mediated gene regulation in the protozoan parasite trichomonas vaginalis. | trichomonas vaginalis is an extracellular flagellated protozoan parasite that causes trichomoniasis, one of the most common non-viral sexually transmitted diseases. to survive and to maintain infection, t. vaginalis adapts to a hostile host environment by regulating gene expression. however, the mechanisms of transcriptional regulation are poorly understood for this parasite. histone modification has a marked effect on chromatin structure and directs the recruitment of transcriptional machinery, ... | 2017 | 28345651 |
| t. vaginalis exosome-like vesicles modify the cytokine profile and reduce inflammation in parasite-infected mice. | trichomonas vaginalis (tv) is a flagellated parasite commonly spread through sexual transmission. this protozoan initiates a severe inflammatory process, inducing nitric oxide, interleukin-6 (il-6), il-8, il-10, il-17, and il-22 production by host immune cells. the parasites elicit these responses by releasing surface lipophosphoglycan, small extracellular vesicles (exosomes) and other factors. tv exosomes are similar to mammalian exosomes and have been implicated in the modulation of il-8 secre ... | 2017 | 28345149 |
| potential of bisbenzimidazole-analogs toward metronidazole-resistant trichomonas vaginalis isolates. | a bisoxyphenylene-bisbenzimidazole series with increasing aliphatic chain length (ch2 to c10 h20 ) containing a meta (m) or para (p) benzimidazole linkage to the phenylene ring was tested for ability to inhibit the growth of metronidazole susceptible (c1) and refractory (085) trichomonas vaginalis isolates under aerobic and anaerobic conditions. compound 3m, 2,2'-[α,ω-propadiylbis(oxy-1,3-phenylene)]bis-1h-benzimidazole, displayed a 5.5-fold lower minimum inhibitory concentration (mic) towards t ... | 2017 | 28296056 |
| antiparasitic activity of 1,3-dioxolanes containing tellurium in trichomonas vaginalis. | the increased prevalence of metronidazole-resistant infections has resulted in a search for alternative drugs for the treatment of trichomoniasis. in the present study, we report the preparation and in vitro activity of three 1,3-dioxolanes that contain tellurium (ptedox 01, ptedox 02, and ptedox 03) against trichomonas vaginalis. six concentrations of these compounds were analyzed for in vitro activity against atcc 30236 isolate of t. vaginalis. ptedox 01 reported a cytotoxic effect against 100 ... | 2017 | 28236702 |
| syndromic diagnosis in evaluation of women with symptoms of vaginitis. | this review aims to determine the effectiveness of the use of syndrome diagnosis in the evaluation of vaginitis and to make suggestions based on the review findings. | 2017 | 28210940 |
| recombinant α-actinin subunit antigens of trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis. | human trichomoniasis caused by trichomonas vaginalis is one of the most common sexually transmitted diseases with more than 200 million cases worldwide. it has caused a series of health problems to patients. for prevention and control of infectious diseases, vaccines are usually considered as one of the most cost-efficient tools. however, until now, work on the development of t. vaginalis vaccines is still mainly focused on the screening of potential immunogens. alpha-actinin characterized by hi ... | 2017 | 28209207 |
| medicinal plants and their isolated compounds showing anti-trichomonas vaginalis- activity. | trichomonas vaginalis is a major of non-viral sexually-transmitted infection and an important cause of serious obstetrical and gynecological complications. treatment options for trichomoniasis are limited to nitroimidazole compounds. the increasing resistance and allergic reactions to nitroimidazole and recurrent trichomoniasis make it essential to identify and develop new drugs against trichomoniasis. medicinal plants are an important source for discovery of new medications. this review discuss ... | 2017 | 28178618 |
| natural products as new treatment options for trichomoniasis: a molecular docking investigation. | trichomoniasis, caused by the parasitic protozoan trichomonas vaginalis, is the most common non-viral sexually-transmitted disease, and there can be severe complications from trichomoniasis. antibiotic resistance in t. vaginalis is increasing, but there are currently no alternatives treatment options. there is a need to discover and develop new chemotherapeutic alternatives. plant-derived natural products have long served as sources for new medicinal agents, as well as new leads for drug discove ... | 2017 | 28134827 |
| in vitro activity of nitazoxanide against some metronidazole-resistant and susceptible trichomonas vaginalis isolates. | trichomonas vaginalis cases refractory to metronidazole (mtz) treatment had been reported. this study aimed to the assessment of in vitro metronidazole resistance among trichomonas positive cases with treatment failure by determination of metronidazole minimal lethal concentration (mlc), and to the evaluation of the in vitro efficacy of nitazoxanide (ntz) as compared to metronidazole (mtz) in both resistant and susceptible isolates. drug testing was carried out by an aerobic tube assay where sus ... | 2017 | 28131737 |
| prevalence of trichomoniasis among 18-48 year-old women in northwest of iran. | the aims of this study were to examine the prevalence of trichomoniasis among women aged 18 to 48 yr in ardabil, northwestern iran and the relationship between demographic factors and the risk of infection. | 2017 | 28127371 |
| molecular characterization of trichomonas vaginalis strains based on identifying their probable variations in asymptomatic patients. | the aim of this study was to identify the trichomonas vaginalis strains/haplotypes based on identifying their probable variations in asymptomatic patients referred to tabriz health centers, northwestern iran. | 2017 | 28127362 |
| detection of sexually transmitted pathogens in patients with chronic prostatitis/chronic pelvic pain: a prospective clinical study. | in <10% of patients with prostatitis syndrome, a causative uropathogenic organism can be detected. it has been shown that certain organisms that cause sexually transmitted infections can also cause chronic bacterial prostatitis, which can be hard to diagnose and treat appropriately because prostatic samples obtained by prostatic massage are not routinely tested to detect them. we conducted a clinical study to determine the prevalence of chlamydia, mycoplasma, and trichomonas infection in 254 pat ... | 2017 | 28120647 |
| clinical performance of the solana® point-of-care trichomonas assay from clinician-collected vaginal swabs and urine specimens from symptomatic and asymptomatic women. | solana® (quidel) is a new rapid (<40 min.) point-of-care (poc) test for qualitative detection of trichomonas vaginalis (tv) dna. the assay has two steps: 1) specimen preparation, and 2) amplification and detection using isothermal helicase-dependent amplification (hda). the objective was to demonstrate the performance of solana for vaginal swabs and female urines based on comparison to wet mount and tv culture. performance was also compared to the aptima-tv assay. | 2017 | 28092466 |
| multiple hpv infections in female sex workers in western kenya: implications for prophylactic vaccines within this sub population. | whilst the imputed role of high risk (hr) hpv infection in the development of cervical lesions and cancer has been established, the high number of hpv genotypes that female sex workers (fsw) harbour warrants that the synergistic effects of potential hr (phr) and hr hpv genotypes be elucidated to assess the potential impact of prophylactic vaccines. this population in kenya also harbours a number of other vaginal infections and stis, including bacterial vaginosis (bv), trichomonas vaginalis (tv) ... | 2017 | 28070215 |
| epigenetics regulates transcription and pathogenesis in the parasite trichomonas vaginalis. | trichomonas vaginalis is a common sexually transmitted parasite that colonizes the human urogenital tract. infections range from asymptomatic to highly inflammatory, depending on the host and the parasite strain. different t. vaginalis strains vary greatly in their adherence and cytolytic capacities. these phenotypic differences might be attributed to differentially expressed genes as a consequence of extra-genetic variation, such as epigenetic modifications. in this study, we explored the role ... | 2017 | 28054438 |
| a nonobstructive azoospermic patient with trichomonas vaginalis infection in testes. | 2017 | 28051042 | |
| a study on the prevalence of genital trichomoniasis among female outpatients attending sexually transmitted infection clinic in a tertiary care hospital. | women with high-risk sexual behavior accounts for more than half of the sexually transmitted infection (sti) clinic attendees. the prevalence of trichomoniasis is as low as 5% in the general population to as high as 60% in high-risk population. this infection can pave the way to the acquisition of human immunodeficiency virus and other stis, vice versa and is even associated with cancer. | 2017 | 28042211 |
| trichomonas vaginalis treated with boric acid in a metronidazole allergic female. | 2017 | 27984554 | |
| the caatinga endemic manilkara rufula possesses remarkable activity against trichomonas vaginalis and tritrichomonas foetus. | tritrichomonas foetus infects the bovine urogenital tract, causing bovine trichomoniasis. significant economic losses may occur due to infertility and abortion among cattle. trichomonas vaginalis is the causative agent of trichomoniasis; the most common but overlooked non-viral sexually transmitted disease worldwide. human and bovine trichomoniasis present treatment restrictions and efforts to identify new alternatives are essential. the present study evaluated the anti-trichomonads activities o ... | 2017 | 27956086 |
| adenosine, but not guanosine, protects vaginal epithelial cells from trichomonas vaginalis cytotoxicity. | trichomonas vaginalis causes the most common non-viral sexually transmitted disease worldwide. the cytoadherence and cytotoxicity upon the vaginal epithelial cells are crucial for the infection. extracellular nucleotides are released during cell damage and, along with their nucleosides, can activate purinoceptors. the opposing effects of nucleotides versus nucleosides are regulated by ectonucleotidases. herein we evaluated the hemolysis and cytolysis induced by t. vaginalis, as well as the extra ... | 2017 | 27871906 |
| snap23-dependent surface translocation of leukotriene b4 (ltb4) receptor 1 is essential for nox2-mediated exocytotic degranulation in human mast cells induced by trichomonas vaginalis-secreted ltb4. | trichomonas vaginalis is a sexually transmitted parasite that causes vaginitis in women and itself secretes lipid mediator leukotriene b4 (ltb4). mast cells are important effector cells of tissue inflammation during infection with parasites. membrane-bridging snare (soluble n-ethylmaleimide-sensitive factor attachment protein receptor) complexes are critical for fusion during exocytosis. although t. vaginalis-derived secretory products (tvsp) have been shown to induce exocytosis in mast cells, i ... | 2017 | 27795355 |
| male partner circumcision associated with lower trichomonas vaginalis incidence among pregnant and postpartum kenyan women: a prospective cohort study. | trichomonas vaginalis is the world's most common curable sti and has implications for reproductive health in women. we determined incidence and correlates of t. vaginalis in an hiv-uninfected peripartum cohort. | 2017 | 27519258 |
| corrigendum to "α-actinin tvactn3 of trichomonas vaginalis is an rna-binding protein that could participate in its posttranscriptional iron regulatory mechanism". | [this corrects the article doi: 10.1155/2014/424767.]. | 2017 | 27517042 |
| diagnosis of trichomoniasis in men by urine cytology. | trichomonas vaginalis is a rare finding in urine cytology specimens, especially those from men; only 2 case reports have been described in the literature. the authors of the current report sought to determine the incidence and clinical significance of this finding in urine cytology in males. | 2017 | 27636204 |
| detecting asymptomatic trichomonas vaginalis in females using the bd probetec™ trichomonas vaginalis q(x) nucleic acid amplification test. | trichomonas vaginalis (tv) rates in women are increasing and many are asymptomatic. nucleic acid amplification tests (naats) are becoming the 'gold standard' for diagnosis. we aimed to establish our asymptomatic tv rates by testing all women attending oxfordshire's sexual health service, regardless of symptoms, using the bd probetec™ tv q(x) naats (bdq(x)). during bdq(x)'s verification process, the sensitivity and specificity were calculated using results of 220 endocervical samples from symptom ... | 2017 | 27150360 |
| in vitro susceptibility of iranian isolates of trichomonas vaginalis to metronidazole. | metronidazole, a 5-nitroimidazole derivative, is the main antitrichomonal agent of choice for treatment of trichomoniasis. since 1962, some cases of treatment failure with metronidazole have been reported and recently drug resistance is now on the rise in the world. this study was aimed to determine current susceptibility of iranian isolates of trichomonas vaginalis to metronidazole. | 2017 | 27095968 |
| mechanisms of tritrichomonas foetus pathogenicity in cats with insights from venereal trichomonosis. | almost 20 years has passed since trichomonosis was first recognized as a potential cause of diarrhea in domestic cats. despite progress in confirming disease causation, developing means for diagnosis, and identifying approaches to treatment of the infection, we still know very little about how this parasite causes diarrhea. with increasing recognition of resistance of trichomonosis to treatment with 5-nitroimidazole drugs, new treatment strategies based on an understanding of disease pathogenesi ... | 2017 | 26946069 |
| in situ forming pluronic® f127/chitosan hydrogel limits metronidazole transmucosal absorption. | the objective of this work is to design topically-applied thermosensitive and mucoadhesive hydrogel containing metronidazole (mtz) for the treatment of trichomonas vaginalis infections. hydrogel composed of pluronic® f127 (20wt%), chitosan (1wt%) and metronidazole mtz (0.7wt%) mixture showed its ability to decrease by a factor 4 mtz flux and apparent permeability absorption through vaginal mucosa. the impact of hydrogel on transmucosal penetration of mtz was evaluated ex vivo on excised porcine ... | 2017 | 27890510 |
| a diagnostic and symptomatological study on trichomoniasis in symptomatic pregnant women in rafsanjan, south central iran in 2012-13. | trichomonas vaginalis, the causative agent of trichomoniasis, is responsible for more than half of all sexually transmitted infections (stis). the present study aimed to determine the frequency of t. vaginalis infection and its clinical manifestations in symptomatic pregnant women in the area based on four different diagnostic methods. | 2017 | 26622305 |
| prevalence, clinical criteria and sociodemographic predictors of trichomonas vaginalis infection in suspected egyptian women, using direct diagnostic techniques. | the present study aimed to determine the prevalence and associated risk factors of vaginal trichomoniasis in women referred to gynecologic clinic in benha university hospital, egypt. | 2017 | 26622298 |
| synthesis, antiprotozoal activity, and chemoinformatic analysis of 2-(methylthio)-1h-benzimidazole-5-carboxamide derivatives: identification of new selective giardicidal and trichomonicidal compounds. | a series of twelve new 2-(methylthio)-1h-benzimidazole-5-carboxamide derivatives (1-12) were synthesized and their antiparasitic activity was tested in vitro against giardia intestinalis, trichomonas vaginalis and entamoeba histolytica. experimental evaluations showed ic50 values within the nanomolar range for all tested compounds, some showing higher activity than metronidazole and albendazole. a chemoinformatic study was used to compare the structure-activity relationship of the synthesized ca ... | 2017 | 28595066 |
| women with symptoms of a urinary tract infection but a negative urine culture: pcr-based quantification of escherichia coli suggests infection in most cases. | our objective was to examine whether or not women with symptoms of a urinary tract infection but with a negative culture (20%-30%) do have an infection. | 2017 | 28457846 |
| results of real-time multiplex polymerase chain reaction assay in renal transplant recipients with sterile pyuria. | urinary tract infections are a major cause of morbidity and hospitalization after renal transplantation. patients treated with immunosuppressive drugs suffer not only from common uropathogens but also from opportunistic infections caused by unusual uropathogens. sterile pyuria is associated with numerous infectious agents including viruses, fungi, and atypical or fastidious organisms. the objective of this study was to investigate the pathogens using real-time multiplex polymerase chain reaction ... | 2017 | 28735999 |
| synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-nsaid chimeras displaying broad antiprotozoal spectrum. | we designed and synthesized five new 5-nitrothiazole-nsaid chimeras as analogues of nitazoxanide, using a dcc-activated amidation. compounds 1-5 were tested in vitro against a panel of five protozoa: 2 amitochondriates (giardia intestinalis, trichomonas vaginalis) and 3 kinetoplastids (leishmania mexicana, leishmania amazonensis and trypanosoma cruzi). all chimeras showed broad spectrum and potent antiprotozoal activities, with ic50 values ranging from the low micromolar to nanomolar order. comp ... | 2017 | 28645659 |
| genetic indicators of drug resistance in the highly repetitive genome of trichomonas vaginalis. | trichomonas vaginalis, the most common nonviral sexually transmitted parasite, causes ∼283 million trichomoniasis infections annually and is associated with pregnancy complications and increased risk of hiv-1 acquisition. the antimicrobial drug metronidazole is used for treatment, but in a fraction of clinical cases, the parasites can become resistant to this drug. we undertook sequencing of multiple clinical isolates and lab derived lines to identify genetic markers and mechanisms of metronidaz ... | 2017 | 28633446 |
| antimicrobial activity of organometallic isonicotinyl and pyrazinyl ferrocenyl-derived complexes. | isonicotinyl and pyrazinyl ferrocenyl-derived complexes were prepared using various hydrazides and ferrocenyl aldehydes. three heterobimetallic complexes were also synthesized from the schiff base-derived isonicotinyl ferrocene complex using various platinum group metal dimers based on ruthenium, rhodium and iridium. all complexes were evaluated in vitro for antimycobacterial and antiparasitic activity. against mycobacterium tuberculosis h37rv, the platinum group metal complexes showed glycerol- ... | 2017 | 28713884 |
| detecting the diversity of mycoplasma and ureaplasma endosymbionts hosted by trichomonas vaginalis isolates. | objectives: the symbiosis of trichomonas vaginalis and mycoplasma hominis is the first described association between two obligate human parasites. trichomonas is the niche and the vector for the transmission of m. hominis infection. this clinically significant symbiosis may affect t. vaginalis virulence and susceptibility to treatment. the aims of this study were to investigate the intracellularly present mycoplasma and ureaplasma species in t. vaginalis strains isolated from the vaginal dischar ... | 2017 | 28702014 |
| double-stranded rna viral infection of trichomonas vaginalis (tvv1) in iranian isolates. | the totiviridae family includes a number of viruses that can infect protozoan parasites such as leishmania and giardia and fungi like saccharomyces cerevisiae. some isolates of trichomonas vaginalis are also infected with one or more double-stranded rna (dsrna) viruses. in this study, the frequency of trichomonas vaginalis virus (tvv1) was evaluated in iranian isolates of t. vaginalis in tehran, iran. one thousand five hundred vaginal samples were collected from patients attending obstetrics and ... | 2017 | 28478201 |
| cryo-em structures of the 80s ribosomes from human parasites trichomonas vaginalis and toxoplasma gondii. | as an indispensable molecular machine universal in all living organisms, the ribosome has been selected by evolution to be the natural target of many antibiotics and small-molecule inhibitors. high-resolution structures of pathogen ribosomes are crucial for understanding the general and unique aspects of translation control in disease-causing microbes. with cryo-electron microscopy technique, we have determined structures of the cytosolic ribosomes from two human parasites, trichomonas vaginalis ... | 2017 | 28809395 |
| role of α-actinin 2 in cytoadherence and cytotoxicity of trichomonas vaginalis. | trichomonas vaginalis is a pathogen that triggers severe immune responses in hosts. t. vaginalis α-actinin 2 (tvα-actinin 2), has been used to diagnose trichomoniasis. tvα-actinin 2 was dissected into three parts, the n-terminal, central, and c-terminal portions of the protein (#1, #2, and #3, respectively). western blot of these tvα-actinin 2 proteins with pooled patients' sera indicated that tvα-actinin 2 #2 and #3, but not tvα-actinin 2 #1, reacted with those sera. immunofluorescence assays o ... | 2017 | 28838225 |
| vaginal infections in haitian immigrant women living in miami, florida. | to characterize vulvovaginal candidiasis (vc), trichomonas vaginalis (tv), and bacterial vaginosis (bv) among haitian women living in miami to identify contributing factors to cervical cancer disparity in this population. | 2017 | 28804083 |
| a competent catalytic active site is necessary for substrate induced dimer assembly in triosephosphate isomerase. | the protozoan parasite trichomonas vaginalis contains two nearly identical triosephosphate isomerases (tvtims) that dissociate into stable monomers and dimerize upon substrate binding. herein, we compare the role of the "ball and socket" and loop 3 interactions in substrate assisted dimer assembly in both tvtims. we found that point mutants at the "ball" are only 39 and 29-fold less catalytically active than their corresponding wild-type counterparts, whereas loop 3 deletions are 1502 and 9400-f ... | 2017 | 28803140 |
| demographic and behavioural risk factors associated with trichomonas vaginalis among south african hiv-positive men with genital ulcer disease: a cross-sectional study. | demographic and risky sexual behaviours may increase the risk for trichomonas vaginalis (tv) infection and, thus, enhance hiv transmission to uninfected partners. we assessed the demographic and behavioural risk factors associated with tv among south african hiv-positive men with genital ulcer disease. | 2017 | 28765124 |
| considerable genetic diversity of trichomonas vaginalis clinical isolates in a targeted population in south of iran. | the present study aimed to characterize genetically and to compare the most frequently occurring strains of trichomonas vaginalis isolated from southern iran. | 2017 | 28761486 |
| genotyping, drug susceptibility and prevalence survey of trichomonas vaginalis among women attending gynecology clinics in hamadan, western iran, in 2014-2015. | in spite of sufficient knowledge about phenotypic variation of trichomonas vaginalis, its genetic characteristics are poorly understood. we carried out a molecular epidemiology study in which in vitro metronidazole susceptibility of t. vaginalis isolates was considered. | 2017 | 28761458 |
| therapeutic effects of iranian herbal extracts against trichomonas vaginalis | trichomonas vaginalis is a flagellated parasite affecting about 276 million people annually worldwide. tricomoniasis is associated with different complications in pregnant women and infants. 5'-nitroimidazole derivatives (metronidazole, ornidazole, and tinidazole) are fda approved drugs recommended for trichomoniasis treatment. treatment with metronidazole 5'-nitroimidazole derivatives is associated with many side effects, and drug resistance to metronidazole has been reported in some cases. rec ... | 2017 | 28755655 |
| genome-wide identification, in silico characterization and expression analysis of zip-like genes from trichomonas vaginalis in response to zinc and iron. | trace elements such as zinc and iron are essential components of metalloproteins and serve as cofactors or structural elements for enzymes involved in several important biological processes in almost all organisms. because either excess or insufficient levels of zn and fe can be harmful for the cells, the homeostatic levels of these trace minerals must be tightly regulated. the zinc regulated transporter, iron regulated transporter-like proteins (zip) comprise a diverse family, with several para ... | 2017 | 28733845 |
| rapid and point-of-care tests for the diagnosis of trichomonas vaginalis in women and men. | trichomonasvaginalis (tv) is a highly prevalent parasitic infection worldwide. it is associated with many adverse reproductive health outcomes. many infections are asymptomatic and syndromic management leads to underdetection of tv. traditional methods of tv detection such as wet preparation are insensitive. new rapid, point-of-care (poc) tests can enhance the diagnosis of trichomoniasis. | 2017 | 28684611 |
| very low sensitivity of wet mount microscopy compared to pcr against culture in the diagnosis of vaginal trichomoniasis in uganda: a cross sectional study. | trichomonas vaginalis (tv) causes the trichomoniasis syndrome composed of vaginitis in women, urethritis in men and tube infection in both sexes. this infection is strongly associated with premature rupture of membranes, preterm delivery, low birth weight, promoting hiv sexual transmission and infertility. prevention of these complications requires accurate early detection and effective treatment of infected individuals. in the resource limited settings, the wet mount microscopy (wmm) is often t ... | 2017 | 28683790 |
| trichomonas vaginalis is rare among women in iceland. | 2017 | 28681060 | |
| polyamine transport and synthesis in trichomonas vaginalis: potential therapeutic targets. | polyamines are essential for many biological processes in all organisms. here we show a current landscape of studies and strategies implemented for the study of polyamine metabolism, as well as molecular aspects that implicate the role of key enzymes, transport proteins, inhibitors, and the study of novel molecules as potential therapeutic targets. this review focused on the synthesis, interconversion and function of these molecules in trichomonas vaginalis, a common sexually transmitted parasit ... | 2017 | 28671057 |
| trichomonas vaginalis infection and risk of prostate cancer: associations by disease aggressiveness and race/ethnicity in the plco trial. | results from previous sero-epidemiologic studies of trichomonas vaginalis infection and prostate cancer (pca) support a positive association between this sexually transmitted infection and aggressive pca. however, findings from previous studies are not entirely consistent, and only one has investigated the possible relation between t. vaginalis seropositivity and pca in african-american men who are at highest risk of both infection and pca. therefore, we examined this possible relation in the pr ... | 2017 | 28669054 |
| antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives. | the 7-benzylidenenaltrexone (bntx) derivatives 2a-v, 3a-c, 13a-c, and 14a were synthesized from naltrexone (1) and evaluated for their antitrichomonal activity. the structure-activity-relationship studies found that 4-iodo-bntx (2g) showed the highest activity (ic50=10.5µm) and the affinity for the opioid receptor was less important for antitrichomonal activity against trichomonas vaginalis. the morphinan skeleton bearing both the double bond for a michael acceptor and the phenolic hydroxy group ... | 2017 | 28662966 |
| candidatus mycoplasma girerdii replicates, diversifies, and co-occurs with trichomonas vaginalis in the oral cavity of a premature infant. | genital mycoplasmas, which can be vertically transmitted, have been implicated in preterm birth, neonatal infections, and chronic lung disease of prematurity. our prior work uncovered 16s rrna genes belonging to a novel, as-yet-uncultivated mycoplasma (lineage 'mnola') in the oral cavity of a premature neonate. here, we characterize the organism's associated community, growth status, metabolic potential, and population diversity. sequencing of genomic dna from the infant's saliva yielded 1.44 gb ... | 2017 | 28630471 |
| audit of trichomonas vaginalis test requesting by community referrers after a change from culture to molecular testing, including a cost analysis. | trichomonas vaginalis (tv) prevalence varies among different communities and peoples. the availability of robust molecular platforms for the detection of tv has advanced diagnosis; however, molecular tests are more costly than phenotypic methodologies, and testing all urogenital samples is costly. we recently replaced culture methods with the aptima trichomonas vaginalis nucleic acid amplification test on specific request and as reflex testing by the laboratory, and have audited this change. | 2017 | 28617786 |
| trichomonas vaginalis is very rare among women with vaginal discharge in podlaskie province, poland. | trichomonas vaginalis is the most common curable sexually transmitted pathogen globally. however, in the european union (eu), trichomoniasis appears to be a rare condition. the aim of this study was to examine the prevalence of t. vaginalis among females attending an sti centre in bialystok, poland, using the highly sensitive and specific aptima t. vaginalis assay. consecutive females, referred by gynaecologists mainly because of abnormal vaginal discharge, were diagnosed using wet mount microsc ... | 2017 | 28612378 |
| unique trichomonas vaginalis gene sequences identified in multinational regions of northwest china. | trichomonas vaginalis (t. vaginalis) is a flagellated protozoan parasite that infects humans worldwide. this study determined the sequence of the 18s ribosomal rna gene of t. vaginalis infecting both females and males in xinjiang, china. samples from 73 females and 28 males were collected and confirmed for infection with t. vaginalis, a total of 110 sequences were identified when the t. vaginalis 18s ribosomal rna gene was sequenced. these sequences were used to prepare a phylogenetic network. t ... | 2017 | 28603223 |
| the fluorescent protein ilov outperforms egfp as a reporter gene in the microaerophilic protozoan trichomonas vaginalis. | trichomonas vaginalis is a flagellated protozoan causing a notorious urogenital infection in humans. due to its anaerobic metabolism, an alternative fluorescent protein that can be readily expressed in oxygen-deprived conditions is ideal. this study assessed the performance of ilov, which does not require oxygen to function, as compared to the conventional enhanced green fluorescent protein (egfp) in t. vaginalis. the results indicated that ilov outperforms egfp in both transient and stable expr ... | 2017 | 28602728 |