Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| primary pyogenic ventriculitis caused by neisseria meningitidis: case report and review of the literature. | background. pyogenic ventriculitis is a well-known complication of meningitis, brain abscesses and intraventricular drains. primary pyogenic ventriculitis is a rare entity and few cases have been described so far. we report the first case of primary pyogenic ventriculitis in an adult caused by neisseria meningitidis and present an overview of all reported adult primary pyogenic ventriculitis cases in the english literature. methods. a pubmed search was performed using the terms ependymitis, vent ... | 2017 | 28348798 |
| evidence of archaeal methanogens in brain abscess. | methanogens are antibiotic-resistant anaerobic archaea which escape routine detection in clinical microbiology. we hypothesized that methanogens may participate as part of the anaerobic community causing brain abscess. | 2017 | 28379309 |
| expressive aphasia caused by streptococcus intermedius brain abscess in an immunocompetent patient. | brain abscess is an uncommon but life-threatening infection. it involves a focal, intracerebral infection that begins in a localized area of cerebritis and develops into a collection of pus, surrounded by a well-vascularized capsule. brain abscess still poses a significant problem in developing countries but rarely in developed countries. predisposing factors vary in different parts of the world. with the introduction of antibiotics and imaging studies, the mortality rate has decreased between 5 ... | 2017 | 28176963 |
| antimicrobial therapy for pyogenic liver abscess secondary to streptococcus intermedius bacteremia. | 2017 | 28079538 | |
| characterization of the pathogenicity of streptococcus intermedius tyg1620 isolated from a human brain abscess based on the complete genome sequence with transcriptome analysis and transposon mutagenesis in a murine subcutaneous abscess model. | streptococcus intermedius is known to cause periodontitis and pyogenic infections in the brain and liver. here we report the complete genome sequence of strain tyg1620 (genome size, 2,006,877 bp; gc content, 37.6%; 2,020 predicted open reading frames [orfs]) isolated from a brain abscess in an infant. comparative analysis of s. intermedius genome sequences suggested that tyg1620 carries a notable type vii secretion system (t7ss), two long repeat regions, and 19 orfs for cell wall-anchored protei ... | 2017 | 27895128 |
| a pilot study using metagenomic sequencing of the sputum microbiome suggests potential bacterial biomarkers for lung cancer. | lung cancer (lc) is the most prevalent cancer worldwide, and responsible for over 1.3 million deaths each year. currently, lc has a low five year survival rates relative to other cancers, and thus, novel methods to screen for and diagnose malignancies are necessary to improve patient outcomes. here, we report on a pilot-sized study to evaluate the potential of the sputum microbiome as a source of non-invasive bacterial biomarkers for lung cancer status and stage. spontaneous sputum samples were ... | 2017 | 28542458 |
| emerging role of actinomyces meyeri in brain abscesses: a case report and literature review. | we describe a case of a 29-year-old man from pakistan who presented with progressive neurologic symptoms over 1 week and was found to have a right parietal cerebral abscess. neurosurgical drainage cultures showed growth of actinomyces meyeri, streptococcus intermedius, and parvimonas micra. an abscessed molar was identified as the likely port of entry and was extracted. the patient was treated with metronidazole, vancomycin, and doxycycline because of prior anaphylaxis to penicillin. at 6-month ... | 2017 | 28831384 |
| periodontal disease and intra-amniotic complications in women with preterm prelabor rupture of membranes. | periodontal disease is frequently suggested as a possible causal factor for preterm delivery. the link between periodontal disease and preterm delivery is a possible translocation of periopathogenic bacteria to the placenta and amniotic fluid as well as a systemic response to this chronic inflammatory disease. however, there is a lack of information on whether there is an association between clinical periodontal status in women with preterm prelabor rupture of membranes (pprom) and the presence ... | 2017 | 28724342 |
| how to become a killer, or is it all accidental? virulence strategies in oral streptococci. | streptococci are a diverse group of gram-positive microorganisms sharing common virulence traits and similar strategies to escape the oral niche and establish an infection in other parts of the host organism. invasive infection with oral streptococci is "a perfect storm" that requires the concerted action of multiple biotic and abiotic factors. our understanding of streptococcal pathogenicity and infectivity should probably be less mechanistic and driven not only by the identification of novel v ... | 2017 | 28727895 |
| streptococcus intermedius: an unusual cause of spinal epidural abscess. | spinal epidural abscess (sea) following dental procedures is a rarely reported entity. here, we present a unique case of a 74-year-old immunocompetent man who developed severe lower back pain and bilateral lower extremity weakness 4 days following two root canal procedures. lumbar spine magnetic resonance imaging (mri) showed several pockets of epidural abscesses extending from l1 through l5. blood cultures grew streptococcus intermedius, an anaerobic commensal bacterium of the normal flora of t ... | 2017 | 28744508 |
| is fch pet able to identify foci of infection superiorly to fdg pet? | we report a case of a brain abscess identified on fluorine-18 choline (fch) positron emission tomography (pet) scan, which was not identified on fluorodeoxyglucose (fdg) pet scan. to our knowledge, there are no previous case reports of incidental brain abscess identified by fch pet imaging. a 51-year-old man, with liver cirrhosis complicated by hepatocellular carcinoma (hcc) was enrolled in a research trial comparing hcc detection in fch pet versus fdg pet. during the course of the trial, he und ... | 2017 | 28710238 |
| a broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria. | the firmicutes are a phylum of bacteria that dominate numerous polymicrobial habitats of importance to human health and industry. although these communities are often densely colonized, a broadly distributed contact-dependent mechanism of interbacterial antagonism utilized by firmicutes has not been elucidated. here we show that proteins belonging to the lxg polymorphic toxin family present in streptococcus intermedius mediate cell contact- and esx secretion pathway-dependent growth inhibition o ... | 2017 | 28696203 |
| marginal bone loss around non-submerged implants is associated with salivary microbiome during bone healing. | marginal bone loss during bone healing exists around non-submerged dental implants. the aim of this study was to identify the relationship between different degrees of marginal bone loss during bone healing and the salivary microbiome. one hundred patients were recruited, and marginal bone loss around their implants was measured using cone beam computed tomography during a 3-month healing period. the patients were divided into three groups according to the severity of marginal bone loss. saliva ... | 2017 | 28621324 |
| positive- and negative-control pathways by blood components for intermedilysin production in streptococcus intermedius. | streptococcus intermedius is an opportunistic bacterial pathogen secreting a human-specific cytolysin called intermedilysin (ily) as a major pathogenic factor. this bacterium can degrade glycans into monosaccharides using two glycosidases, multisubstrate glycosidase a (msga) and neuraminidase (nana). here, we detected a stronger hemolytic activity mediated by ily when s. intermedius pc574 was cultured in fetal bovine serum (fbs) than when it was grown in the standard culture medium. fbs-cultured ... | 2017 | 28607101 |
| a case of acute clival osteomyelitis in a 7-year-old boy secondary to infection of a thornwaldt cyst. | clival osteomyelitis is a potentially life-threatening infection that can occur in healthy children. it can be related to congenital anomalies. we report the case of a 7-year-old boy with streptococcus intermedius and fusobacterium clival osteomyelitis arising from a thornwaldt cyst situated in a fossa navicularis magna of the occipital bone. multidisciplinary management is necessary to ensure rapid improvement and complete healing. | 2017 | 28576541 |
| osteomyelitis of the mandible after dental implants in an immunocompetent patient. | dental implants are now broadly used to replace missing teeth, and the presence of infectious complications is rising. dental implant therapy as a local risk factor for the onset of osteomyelitis and its management have not been widely explored. here, we report an unusual case of mandibular suppurative osteomyelitis caused by streptococcus intermedius in a healthy and immunocompetent patient secondary to mandibular implants. we describe how surgery combined with systemic application of antibioti ... | 2017 | 28469945 |
| isolated streptococcus intermedius pulmonary nodules. | streptococcus intermedius, a member of the streptococcal anginosus group of alpha-hemolytic streptococci, remains a notable infectious agent causing necrotizing pneumonia and abscesses. we report a case of a young male with pulmonary nodules found to have streptococcus intermedius and no other underlying hepatic or dental history who was treated with ceftriaxone and avoided surgical intervention. a review of the literature reveals cases that are typically treated with a combined surgical and med ... | 2017 | 28409118 |
| streptococcus intermedius causing necrotizing pneumonia in an immune competent female: a case report and literature review. | we report a case of a 52-year-old immunocompetent caucasian female treated for necrotizing streptococcus intermedius pneumonia and review available literature of similar cases. our patient presented with respiratory failure and required hospitalization and treatment in the intensive care unit. moreover, she required surgical drainage of right lung empyema as well as decortication and resection. the review of literature revealed three cases of s. intermedius pneumonia, one of which was a mortalit ... | 2016 | 27891283 |
| cervical facet joint infection and associated epidural abscess with streptococcus intermedius from a dental infection origin a case report and review. | pyogenic cervical facet joint infections are rare and such infections from a dental origin are even less common. of these few cases, none have described infection with streptococcus intermedius as the pathogen. a 65-year-old orthopaedic surgeon complained of fevers, right-sided radiating neck pain, stiffness, swelling, erythema, and right upper extremity weakness one month after he had broken a crown over his right mandibular premolar, a continued source of pain. imaging of the cervical spine sh ... | 2016 | 27620549 |
| rapid conditional targeted ablation model for hemolytic anemia in the rat. | effective methods for cell ablation are important tools for examining the anatomical, functional, and behavioral consequences of selective loss of specific cell types in animal models. we have developed an ablation system based on creating genetically modified animals that express human cd59 (hcd59), a membrane receptor, and administering intermedilysin (ily), a toxin produced by streptococcus intermedius, which binds specifically to hcd59 to induce cell lysis. as proof-of-concept in the rat, we ... | 2016 | 27368711 |
| infections associated with streptococcus intermedius in children. | streptococcus intermedius is a viridans streptococcus belonging to the anginosus group. in the past 7 years, it has been associated with abscesses in 48 children, 40% of whom had complicated and/or life-threatening illness. it was the sole pathogen in 35 cases. seventy-five percent of the infections occurred in winter and spring. none occurred in infants younger than 1 year. | 2016 | 27294306 |
| rapid identification of streptococcus intermedius by multiplex polymerase chain reaction 1 week before culture positivity in a patient with antibiotic-treated thalamic brain abscess. | 2016 | 27262210 | |
| cre-inducible human cd59 mediates rapid cell ablation after intermedilysin administration. | cell ablation is a powerful tool for studying cell lineage and/or function; however, current cell-ablation models have limitations. intermedilysin (ily), a cytolytic pore-forming toxin that is secreted by streptococcus intermedius, lyses human cells exclusively by binding to the human complement regulator cd59 (hcd59), but does not react with cd59 from nonprimates. here, we took advantage of this feature of ily and developed a model of conditional and targeted cell ablation by generating floxed ... | 2016 | 27159394 |
| gastrointestinal stromal tumor as entry port for s. intermedius causing bacteremia and multiple liver abscesses. case report and review of literature. | we report a case of a previously healthy 52-year-old man who presented with fever and liver lesions suspicious for metastatic disease, which proved subsequently to be abscesses. further workup revealed a gastrointestinal stromal tumor (gist) in the gastric corpus as entry port to streptococcus intermedius-associated bacteremia and liver abscesses. after antibiotic treatment and surgical resection of the tumor, the patient recovered well. this unusual case indicates that gastrointestinal stromal ... | 2016 | 27043888 |
| [detection of early gastric cancer facilitated by surveillance for a pyogenic liver abscess caused by streptococcus intermedius]. | we report a case of early gastric cancer that was detected during surveillance of a pyogenic liver abscess caused by streptococcus intermedius, an oral microbiota. treatment with proton pump inhibitors can result in the alteration of gastric bacterial flora by altering intragastric acidity. this can place immunocompromised patients, such as those with diabetes mellitus and the elderly, at an increased risk for disease of the upper gastrointestinal tract to be a route of bacterial transmission. i ... | 2016 | 26853986 |
| toxic levels of ammonia in human brain abscess. | brain abscesses could lead to cerebral symptoms through tissue destruction, edema, changes in brain architecture, and increased intracranial pressure. however, the possibility that the pus itself could contribute to symptoms has received little attention. brain abscesses are areas of tissue destruction, proteolysis, and formation of free amino acids, which are energy substrates for bacteria and possible sources of ammonia. ammonia is neurotoxic, may cause brain edema, and could contribute to the ... | 2016 | 26274996 |
| hydroalcoholic extract of carum carvi l. in oral mucositis: a clinical trial in male golden hamsters. | several studies have attempted to prevent or improve oral mucositis (om) but have not produced a qualified treatment yet. this study evaluates the effects of carum carvi l. (caraway) hydroalcoholic extract (che) as one of the traditional medicinal plants in 5-fluorouracil (5-fu)-induced om in golden hamsters. | 2016 | 26407909 |
| a case of multiple empyema caused by streptococcus intermedius. | we report the case of a patient with multiple empyema present throughout his body, including chronic sinusitis and chronic suppurative otitis media, as well as subsequent epidural empyema, all caused by streptococcus intermedius. a 38-year-old man presented with chief complaints of headache, left ear discharge, and nasal congestion. imaging studies revealed pansinusitis, soft tissue signs in the mastoid cells, and otitis media. the patient was treated with meropenem hydrate, 6g/day. while clinic ... | 2016 | 27913087 |
| insidious manifestation of pyogenic liver abscess caused by streptococcus intermedius and micrococcus luteus: a case report. | pyogenic liver abscesses are caused by various microorganisms and usually present with fever, abdominal pain, leukocytosis and liver enzyme abnormalities. this case presents the insidious manifestation of a pyogenic liver abscess in a 34-year-old immunocompetent male, where classical manifestations of a liver abscess were absent. the microorganisms cultured from the abscess belonged to oral cavity's and gastrointestinal tract's normal flora. | 2016 | 26770811 |
| [reactivation of tuberculosis presenting with empyema due to anticancer chemotherapy for diffuse large b cell lymphoma]. | a 79-year-old man with a history of tuberculosis was found to have chronic empyema in the right lung and was diagnosed with malignant diffuse large-cell lymphoma (ann arbor stage iie). after completion of one course of rituximab plus cyclophosphamide, pirarubicin, vincristine, and prednisolone (r-chop) chemotherapy, the patient developed lung abscess and sepsis caused by streptococcus intermedius. this condition was treated with antimicrobial agents, and chemotherapy was resumed. after the secon ... | 2016 | 27530021 |
| the sil locus in streptococcus anginosus group: interspecies competition and a hotspot of genetic diversity. | the streptococcus invasion locus (sil) was first described in streptococcus pyogenes and streptococcus pneumoniae, where it has been implicated in virulence. the two-component peptide signaling system consists of the sila response regulator and silb histidine kinase along with the silcr signaling peptide and sild/e export/processing proteins. the presence of an associated bacteriocin region suggests this system may play a role in competitive interactions with other microbes. comparative analysis ... | 2016 | 28119678 |
| case-control study of pneumonia patients with streptococcus anginosus group bacteria in their sputum. | in recent years, streptococcus anginosus group (sag) bacteria are becoming increasingly recognized as important pneumonia-causing pathogens. although several small studies have been reported, the features of sag pneumonia remain unclear, because the identification of sag from sputum cultures is not routinely performed in most microbiology laboratories. the aim of this study was to elucidate the clinical characteristics of sag pneumonia. | 2016 | 27681235 |
| streptococcus anginosus (milleri) group strains isolated in poland (1996-2012) and their antibiotic resistance patterns. | streptococcus anginosus, streptococcus intermedius and streptococcus constellatus form a group of related streptococcal species, namely the streptococcus anginosus group (sag). the group, previously called "milleri" had been rarely described until 1980/1990 as source of infections. nowadays sag bacteria are often described as pathogens causing predominantly purulent infections. the number of infections is highly underestimated, as sag strains are often classified in the microbiology laboratory a ... | 2016 | 27281992 |
| the streptococcus milleri group in chronic obstructive pulmonary disease. | s. anginosus, constellatus and intermedius, also known as the streptococcus milleri group (smg) are three streptococcal species more frequently detected in cases of invasive disease, abscesses and empyema in particular. recent research suggests they play a role in exacerbations of cystic fibrosis (cf). owing to poor recovery on standard culture media and difficult differentiation from non-pathogenic streptococci, smg may be underdiagnosed in routine settings. we aimed to establish the incidence ... | 2016 | 27132809 |
| pyogenic ventriculitis as clinical presentation of diverticulitis. | 2016 | 26928780 | |
| microbial diversity in the early in vivo-formed dental biofilm. | although the mature dental biofilm composition is well studied, there is very little information on the earliest phase of in vivo tooth colonization. progress in dental biofilm collection methodologies and techniques of large-scale microbial identification have made new studies in this field of oral biology feasible. the aim of this study was to characterize the temporal changes and diversity of the cultivable and noncultivable microbes in the early dental biofilm. samples of early dental biofil ... | 2016 | 26746720 |
| in vitro effect of porphyromonas gingivalis methionine gamma lyase on biofilm composition and oral inflammatory response. | methanethiol (methyl mercaptan) is an important contributor to oral malodour and periodontal tissue destruction. porphyromonas gingivalis, prevotella intermedia and fusobacterium nucleatum are key oral microbial species that produce methanethiol via methionine gamma lyase (mgl) activity. the aim of this study was to compare an mgl knockout strain of p. gingivalis with its wild type using a 10-species biofilm co-culture model with oral keratinocytes and its effect on biofilm composition and infla ... | 2016 | 28033374 |
| late infectious endocarditis of surgical patch closure of atrial septal defects diagnosed by 18f-fluorodeoxyglucose gated cardiac computed tomography (18f-fdg-pet/ct): a case report. | in contrast to percutaneous atrial septal occluder device, surgical patch closure of atrial defects was known to be no infective endocarditis risk. | 2016 | 27557679 |
| [isolation and identification of aerobic and facultative anaerobic bacteria in the oral cavity]. | to establish a systematic method for isolation and identification of aerobic and facultative anaerobic bacteria in the oral cavity. | 2015 | 26714902 |
| functional signatures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis. | periodontitis is a polymicrobial biofilm-induced inflammatory disease that affects 743 million people worldwide. the current model to explain periodontitis progression proposes that changes in the relative abundance of members of the oral microbiome lead to dysbiosis in the host-microbiome crosstalk and then to inflammation and bone loss. using combined metagenome/metatranscriptome analysis of the subgingival microbiome in progressing and non-progressing sites, we have characterized the distinct ... | 2015 | 25918553 |
| streptococcus constellatus causing septic thrombophlebitis of the right ovarian vein with extension into the inferior vena cava. | introduction. streptococcus constellatus collectively with streptococcus anginosus and streptococcus intermedius constitute the streptococcus anginosus (formerly streptococcus milleri) group. though they are commonly associated with abscesses, bacteremia with subsequent septic thrombophlebitis is extremely rare, and resulting mortality is infrequent. case presentation. we report a case of a previously healthy 60-year-old african american female who presented with streptococcus constellatus bacte ... | 2015 | 26171262 |
| the cytolytic activity of vaginolysin strictly depends on cholesterol and is potentiated by human cd59. | gardnerella vaginalis produces cytolysin vaginolysin (vly), which has been suggested to be a contributor to bacterial vaginosis pathogenesis. vly along with intermedilysin (ily) from streptococcus intermedius have been attributed to a group of cholesterol-dependent cytolysins (cdcs) whose pore-forming activity depends on human cd59 (hcd59). here, we show that different types of cells lacking hcd59 are susceptible to vly-mediated lysis, albeit to different extents. we analyze the effects of both ... | 2015 | 25590277 |
| phototargeting human periodontal pathogens in vivo. | the effects of blue light at 455 nm were investigated on the bacterial composition of human dental plaque in vivo. eleven subjects who refrained from brushing for 3 days before and during phototherapy participated in the study. light with a power density of 70 mw/cm(2) was applied to the buccal surfaces of premolar and molar teeth on one side of the mouth twice daily for 2 min over a period of 4 days. dental plaque was harvested at baseline and again at the end of 4 days from eight posterior tee ... | 2015 | 24346334 |
| solitary pyomyositis of the left rhomboideus muscle caused by streptococcus anginosus and streptococcus intermedius in an immunocompetent person. | primary pyomyositis is a bacterial infection of the skeletal muscle commonly affecting children with staphylococcus aureus most often isolated as a pathogen. however, pyomyositis caused by anaerobic bacteria is rare in adults. here, we report a case of solitary pyomyositis of the left rhomboideus muscle in an immunocompetent person. a 70-year-old japanese male presented with high fever and left shoulder pain. his muscle below the lower edge of the left scapula was tender and swollen. his laborat ... | 2015 | 26185692 |
| braın abscess due to streptococcus intermedius secondary to mastoiditis in a child. | brain abscess is a rare but serious, life-threatening infection in children. it may arise from parameningeal infections such as otitis media, sinusitis and mastoiditis. | 2015 | 26722629 |
| a serious mediastinum abscess induced by endobronchial ultrasound-guided transbronchial needle aspiration (ebus-tbna): a case report and review of the literature. | a 75-year-old man with interstitial pneumonia and enlarged mediastinal lymph nodes underwent endobronchial ultrasound-guided transbronchial needle aspiration (ebus-tbna). he developed a high-grade fever seven days after ebus-tbna was performed; laboratory and radiologic findings showed intense inflammatory reactions, with swelling of the mediastinal lymph nodes on chest computed tomography. mediastinal lymph node abscess was diagnosed, and it worsened in spite of systemic antibacterial treatment ... | 2015 | 26466704 |
| giant purulent pericarditis with cardiac tamponade due to streptococcus intermedius rapidly progressing to constriction. | purulent pericardial effusion, although rare, is a life-threatening condition usually produced by the extension of a nearby bacterial infection locus or by blood dissemination in the immune-suppressed subjects or in the course of cardiothoracic surgery. because clinical features of purulent pericardial effusion are often nonspecific, it can cause delay in diagnosis. therefore, a high index of suspicion is required for timely diagnosis and management. herein, we describe a case of giant purulent ... | 2015 | 25735951 |
| streptococcus intermedius as causative agent of perianal abscess and metastatic brain abscess. | 2015 | 24896839 | |
| identification and characterization of a novel secreted glycosidase with multiple glycosidase activities in streptococcus intermedius. | streptococcus intermedius is a known human pathogen and belongs to the anginosus group (s. anginosus, s. intermedius, and s. constellatus) of streptococci (ags). we found a large open reading frame (6,708 bp) in the lac operon, and bioinformatic analysis suggested that this gene encodes a novel glycosidase that can exhibit β-d-galactosidase and n-acetyl-β-d-hexosaminidase activities. we, therefore, named this protein "multisubstrate glycosidase a" (msga). to test whether msga has these glycosida ... | 2014 | 24858187 |
| rapid degradation of the complement regulator, cd59, by a novel inhibitor. | there is increased interest in immune-based monoclonal antibody therapies for different malignancies because of their potential specificity and limited toxicity. the activity of some therapeutic monoclonal antibodies is partially dependent on complement-dependent cytolysis (cdc), in which the immune system surveys for invading pathogens, infected cells, and malignant cells and facilitates their destruction. cd59 is a ubiquitously expressed cell-surface glycosylphosphatidylinositol-anchored prote ... | 2014 | 24616098 |
| a child with purulent pericarditis and streptococcus intermedius in the presence of a pericardial teratoma: an unusual presentation. | 2014 | 24373623 | |
| pathogenic bacterial species associated with endodontic infection evade innate immune control by disabling neutrophils. | endodontic infections, in which oral bacteria access the tooth pulp chamber, are common and do not resolve once established. to investigate the effects of these infections on the innate immune response, we established a mouse subcutaneous chamber model, where a mixture of four oral pathogens commonly associated with these infections (endodontic pathogens [ep]), i.e., fusobacterium nucleatum, streptococcus intermedius, parvimonas micra, and prevotella intermedia, was inoculated into subcutaneousl ... | 2014 | 25024367 |
| pyogenic brain and lung abscesses due to streptococcus intermedius. | 2014 | 24002617 | |
| oesophageal adenocarcinoma presenting with multiple streptococcus intermedius cerebral abscesses. | 2014 | 23828306 | |
| low-back pain, lassitude and loss of appetite. | white blood cells, erythrocyte sedimentation rate and c-reactive protein are sensitive tools to discover rare, but potentially serious pyogenic vertebral osteomyelitis, a disease whose incidence is increasing. | 2014 | 25057398 |
| chromosomal islands of streptococcus pyogenes and related streptococci: molecular switches for survival and virulence. | streptococcus pyogenes is a significant pathogen of humans, annually causing over 700,000,000 infections and 500,000 deaths. virulence in s. pyogenes is closely linked to mobile genetic elements like phages and chromosomal islands (ci). s. pyogenes phage-like chromosomal islands (spyci) confer a complex mutator phenotype on their host. spyci integrate into the 5' end of dna mismatch repair (mmr) gene mutl, which also disrupts downstream operon genes lmrp, ruva, and tag. during early logarithmic ... | 2014 | 25161960 |
| effective oral health in infective endocarditis: efficacy of high-street mouthwashes against the viridans group streptococci. | recent uk national institute for health and clinical excellence guidelines state that there is no longer a need for oral antibiotic prophylaxis in patients undergoing dental procedures who are at risk of infective endocarditis (ie), and advocate the importance of maintaining good oral health. as viridans group streptococci (vgs) are common etiological agents of ie and inhabitants of the mouth, the purpose of this study was to examine the efficacy of common high-street mouthwashes against four cl ... | 2014 | 24610586 |
| antibiotic susceptibility of periodontal streptococcus constellatus and streptococcus intermedius clinical isolates. | streptococcus constellatus and streptococcus intermedius in subgingival dental plaque biofilms may contribute to forms of periodontitis that resist treatment with conventional mechanical root debridement/surgical procedures and may additionally participate in some extraoral infections. because systemic antibiotics are often used in these clinical situations, and little is known of the antibiotic susceptibility of subgingival isolates of these two bacterial species, this study determined the in v ... | 2014 | 25102269 |
| the incidence and risk factors of meningitis after major craniotomy in china: a retrospective cohort study. | meningitis after neurosurgery can result in severe morbidity and high mortality. incidence varies among regions and limited data are focused on meningitis after major craniotomy. | 2014 | 25003204 |
| human-specific bacterial pore-forming toxins induce programmed necrosis in erythrocytes. | a subgroup of the cholesterol-dependent cytolysin (cdc) family of pore-forming toxins (pfts) has an unusually narrow host range due to a requirement for binding to human cd59 (hcd59), a glycosylphosphatidylinositol (gpi)-linked complement regulatory molecule. hcd59-specific cdcs are produced by several organisms that inhabit human mucosal surfaces and can act as pathogens, including gardnerella vaginalis and streptococcus intermedius. the consequences and potential selective advantages of such p ... | 2014 | 25161188 |
| the diversity of receptor recognition in cholesterol-dependent cytolysins. | cholesterol-dependent cytolysins (cdcs) are bacterial pore-forming toxins secreted mainly by pathogenic gram-positive bacteria. cdcs generally recognize and bind to membrane cholesterol to create pores and lyse target cells. however, in contrast to typical cdcs such as streptolysin o, several atypical cdcs have been reported. the first of these was intermedilysin, which is secreted by streptococcus intermedius and has human cell-specificity, human cd59 (hucd59) being its receptor. in the study r ... | 2014 | 24401114 |
| streptococcus intermedius bacteremia and liver abscess following a routine dental cleaning. | streptococcus intermedius is a member of the streptococcus anginosus group of bacteria. this group is part of the normal flora of the oropharynx, genitourinary, and gastrointestinal tracts; however, they have been known to cause a variety of purulent infections including meningitis, endocarditis, and abscesses, even in immunocompetent hosts. in particular, s. intermedius has been associated with the development of liver and brain abscesses. there have been several case reports of s. intermedius ... | 2014 | 25197585 |
| identification of the 'streptococcus anginosus group' by matrix-assisted laser desorption ionization--time-of-flight mass spectrometry. | matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) provides rapid, accurate and cost-effective identification of a range of bacteria and is rapidly changing the face of routine diagnostic microbiology. however, certain groups of bacteria, for example streptococci (in particular viridans or non-haemolytic streptococci), are less reliably identified by this method. we studied the performance of maldi-tof ms for identification of the 'streptococcus anginosus ... | 2014 | 24917618 |
| molecular pathogenicity of streptococcus anginosus. | streptococcus anginosus and the closely related species streptococcus constellatus and streptococcus intermedius, are primarily commensals of the mucosa. the true pathogenic potential of this group has been under-recognized for a long time because of difficulties in correct species identification as well as the commensal nature of these species. in recent years, streptococci of the s. anginosus group have been increasingly found as relevant microbial pathogens in abscesses and blood cultures and ... | 2014 | 24848553 |
| an unusual case of streptococcus anginosus group pyomyositis diagnosed using direct 16s ribosomal dna sequencing. | bacteria belonging to the streptococcus anginosus group (streptococcus intermedius, streptococcus constellatus and streptococcus anginosus) are capable of causing serious pyogenic infections, with a tendency for abscess formation. the present article reports a case of s anginosus group pyomyositis in a 47-year-old man. the pathogen was recovered from one of two blood cultures obtained from the patient, but speciation was initially not performed because the organism was considered to be a contami ... | 2014 | 24634686 |
| a streptolysin s homologue is essential for β-haemolytic streptococcus constellatus subsp. constellatus cytotoxicity. | streptococcus constellatus is a member of the anginosus group streptococci (ags) and primarily inhabits the human oral cavity. s. constellatus is composed of three subspecies: s. constellatus subsp. constellatus (scc), s. constellatus subsp. pharyngis and the newly described subspecies s. constellatus subsp. viborgensis. although previous studies have established that scc contains β-haemolytic strains, the factor(s) responsible for β-haemolysis in β-haemolytic scc (β-scc) has yet to be clarified ... | 2014 | 24600025 |
| pneumonia and empyema caused by streptococcus intermedius that shows the diagnostic importance of evaluating the microbiota in the lower respiratory tract. | the bacterial species in the streptococcus anginosus group (s. constellatus, s. anginosus, s. intermedius) are important causative pathogens of bacterial pneumonia, pulmonary abscesses and empyema. however, the bacteria in this group are primarily oral resident bacteria and unable to grow significantly on ordinary aerobic culture media. we experienced a case of pneumonia and empyema caused by streptococcus intermedius detected using a 16s rrna gene sequencing analysis of bronchoalveolar lavage f ... | 2014 | 24390528 |
| invasive streptococcus anginosus group infection-does the species predict the outcome? | to determine whether there is an association between the species of streptococcus anginosus group (sag) bacteria and the clinical outcome. | 2014 | 24215937 |
| massive parallel sequencing provides new perspectives on bacterial brain abscesses. | rapid development within the field of massive parallel sequencing (mps) is about to bring this technology within reach for diagnostic microbiology laboratories. we wanted to explore its potential for improving diagnosis and understanding of polymicrobial infections, using bacterial brain abscesses as an example. we conducted a prospective nationwide study on bacterial brain abscesses. fifty-two surgical samples were included over a 2-year period. the samples were categorized as either spontaneou ... | 2014 | 24671797 |
| cluster of bacteria associated with peri-implantitis. | information on the microbiota in peri-implantitis is limited. we hypothesized that neither gender nor a history of periodontitis/smoking or the microbiota at implants differ by implant status. | 2014 | 23527870 |
| distinct cytokine pattern in response to different bacterial pathogens in human brain abscess. | brain abscess is a focal suppurative process. host inflammatory response in gram type and specific bacteria has not been studied in brain abscess. a total of 57 brain abscess patients with monomicrobial infections were studied for th1 (tnf-α, ifn-γ, il1-β), th2 (il-4, il-10) and th17 (il-17, il-23) cytokine response by reverse-transcriptase pcr and elisa. th1 and th17 cytokines were significantly elevated in gram positive (staphylococcus aureus and streptococcus intermedius) and th2 cytokine (il ... | 2014 | 24910026 |
| septic thrombophlebitis of the superior mesenteric vein with bacteraemia caused by bacteroides fragilis and streptococcus intermedius as a complication of diverculitis. | a 68-year-old japanese man with alcoholic liver cirrhosis was admitted to our hospital because of fever and haematemesis. on day 3, his blood culture became positive for gram-negative bacilli and gram-positive cocci, and contrast-enhanced abdominal ct revealed acute septic thrombophlebitis of the superior mesenteric vein with caecal diverculitis. antimicrobial therapy with ampicillin-sulbactam and anticoagulant therapy were started and the blood culture grew bacteroides fragilis and streptococcu ... | 2013 | 23389727 |
| subgingival microflora in inflammatory bowel disease patients with untreated periodontitis. | to analyze the subgingival microflora composition of inflammatory bowel disease (ibd) patients with untreated chronic periodontitis and compare them with systemically healthy controls also having untreated chronic periodontitis. | 2013 | 23060013 |
| molecular mapping to species level of the tonsillar crypt microbiota associated with health and recurrent tonsillitis. | the human palatine tonsils, which belong to the central antigen handling sites of the mucosal immune system, are frequently affected by acute and recurrent infections. this study compared the microbiota of the tonsillar crypts in children and adults affected by recurrent tonsillitis with that of healthy adults and children with tonsillar hyperplasia. an in-depth 16s rrna gene based pyrosequencing approach combined with a novel strategy that included phylogenetic analysis and detection of species ... | 2013 | 23437130 |
| arginine deiminase inhibits porphyromonas gingivalis surface attachment. | the oral cavity is host to a complex microbial community whose maintenance depends on an array of cell-to-cell interactions and communication networks, with little known regarding the nature of the signals or mechanisms by which they are sensed and transmitted. determining the signals that control attachment, biofilm development and outgrowth of oral pathogens is fundamental to understanding pathogenic biofilm development. we have previously identified a secreted arginine deiminase (adi) produce ... | 2013 | 23242802 |
| [streptococcus intermedius: a rare cause of brain abscess in children]. | streptococcus intermedius is a member of the streptococcus anginosus group, also known as the streptococcus milleri group. although this is a commensal agent of the mouth and upper airways, it has been recognized as an important pathogen in the formation of abscesses. however, it has rarely been involved in the formation of brain abscess in children. we report 4 pediatric cases of brain abscess caused by s. intermedius. three boys and 1 girl, all aged over 2 years, were admitted for a febrile me ... | 2013 | 23375710 |
| a case of spontaneous abscess of the corpus cavernosum. | spontaneous abscess of the corpus cavernosum is an extremely rare presentation. this is the first documented case of corpus cavernosal abscess caused exclusively by organisms from the streptococcus milleri group, which have previously been described as being associated with abscess formation. this report outlines the case of a 56-year-old alcoholic male with no risk factors who presented with an 8-day history of penile pain, swelling and sepsis. a diagnosis of abscess of the right corpus caverno ... | 2013 | 23506057 |
| comparing biocompatibility of gingival fibroblasts and bacterial strains on a different modified titanium discs. | the modification of implant surface situated in the area of peri-implant sulcus has important role in bacterial and cell adhesion. six different chemically and physically modified titanium discs were prepared: glazed (tis-malp), unglazed (tis-o), unglazed and alkali-etched (tis-oa), unglazed and coated with zrn (tis-oz), unglazed, sand blasted, and acid etched (tis-opae), and unglazed, sand blasted, acid, and alkali etched (tis-opaae). analysis of surface topography was determined using scanning ... | 2013 | 23529774 |
| streptococcus danieliae sp. nov., a novel bacterium isolated from the caecum of a mouse. | we report the characterization of one novel bacterium, strain erd01g(t), isolated from the cecum of a tnf(deltaare) mouse. the strain was found to belong to the genus streptococcus based on phylogenetic analysis of partial 16s rrna gene sequences. the bacterial species with standing name in nomenclature that was most closely related to our isolate was streptococcus alactolyticus (97 %). the two bacteria were characterized by a dna-dna hybridization similarity value of 35 %, demonstrating that th ... | 2013 | 23052149 |
| lacr mutations are frequently observed in streptococcus intermedius and are responsible for increased intermedilysin production and virulence. | streptococcus intermedius secretes a human-specific cytolysin, intermedilysin (ily), which is considered to be the major virulence factor of this pathogen. we screened for a repressor of ily expression by using random gene disruption in a low-ily-producing strain (pc574). three independent high-ily-producing colonies that had plasmid insertions within a gene that has high homology to lacr were isolated. validation of these observations was achieved through disruption of lacr in strain pc574 with ... | 2013 | 23798532 |
| effects of extracellular dna and dna-binding protein on the development of a streptococcus intermedius biofilm. | the aim of this study was to clarify the effects of homologous and heterologous extracellular dnas (ednas) and histone-like dna-binding protein (hlp) on streptococcus intermedius biofilm development and rigidity. | 2013 | 23551549 |
| genome sequence of the human abscess isolate streptococcus intermedius ba1. | streptococcus intermedius is a human pathogen with a propensity for abscess formation. we report a high-quality draft genome sequence of s. intermedius strain ba1, an isolate from a human epidural abscess. this sequence provides insight into the biology of s. intermedius and will aid investigations of pathogenicity. | 2013 | 23405291 |
| rapidly progressive paraplegia and pleural empyema: how does that correlate? | a 74-year-old man presented with progressive dyspnea after a 10-days latency following a thoracic trauma. ct imaging showed multiple rib fracture and an empyema that was primarily treated by a chest tube. in the course of the hospital stay, a rapidly progressive paraplegia developed and the mr imaging revealed a peridural abscess caused by a pleural empyema. due to trauma-related barrier damage and the initial delay of the operative therapy a usually less invasive pathogen (streptococcus interme ... | 2013 | 23275088 |
| a brain abscess of probable odontogenic origin in a child with cyanotic heart disease. | the purpose of the present report was to present a rare case of a brain abscess in a child with heterotaxy syndrome, severe cardiac anomalies, and extensive dental caries. the pathogen was streptococcus intermedius isolated from the cerebrospinal fluid. the source of the pathogen was probably an infection of a primary molar with a dentoalveolar abscess involving the bud of the permanent successor. after a long course of antibiotic regimens followed by a craniotomy with abscess drainage, a shunt, ... | 2013 | 23211917 |
| the role of streptococcus intermedius in brain abscess. | brain abscess represents a significant medical problem, despite recent advances made in detection and therapy. streptococcus intermedius, a commensal organism, has the potential to cause significant morbidity. s. intermedius expresses one or more members of a family of structurally and antigenically related surface proteins termed antigen i/ii, which plays a potential role in its pathogenesis. it is involved in binding to human fibronectin and laminin and in inducing il-8 release from monocytes, ... | 2013 | 23187823 |
| pyogenic liver abscess following acupuncture and moxibustion treatment. | acupuncture treatment is generally regarded as a relatively safe procedure. however, most procedures have some complications and acupuncture treatment is no exception. reported complications of acupuncture treatment were mostly mild or temporary symptoms, but certain severe adverse effects were also observed. we report here for the first time a case of liver abscess following acupuncture and moxibustion treatment. | 2013 | 24106589 |
| [a case of culture-negative brain abscess caused by streptococcus intermedius infection diagnosed by broad-range pcr of 16s ribosomal rna]. | a 50-year-old man presented with altered mental status during hospitalization for pneumonia. mri showed multifocal ring-enhanced lesions, which consisted of multiple cerebral abscesses. we started empirical antibiotic therapy, but the following morning, his condition rapidly deteriorated and a ct scan revealed acute hydrocephalus, which required ventricular drainage. gram staining of cerebro-spinal fluid from the ventricular drainage showed gram-positive cocci in chains, but culture results were ... | 2013 | 24101431 |
| identification of streptococcus intermedius central nervous system infection by use of pcr and electrospray ionization mass spectrometry. | we describe the utility of pcr and electrospray ionization with mass spectrometry (pcr/esi-ms) of culture-negative cerebrospinal fluid (csf) in order to identify gram-positive cocci noted on a gram stain of csf from a previously healthy 26-year-old man with community-acquired pneumonia (cap) and multiple brain abscesses. csf samples were obtained 2 weeks apart, first by lumbar puncture and 2 weeks later from an external ventricular drain that was inserted into the right ventricle. both csf cultu ... | 2012 | 23035188 |
| involvement of commensal bacteria may lead to dysregulated inflammatory and autoimmune responses in a mouse model for chronic nonsuppurative destructive cholangitis. | we previously reported a mouse model of primary biliary cirrhosis (pbc)-like chronic nonsuppurative destructive cholangitis (cnsdc), in which frequent injections of streptococcus intermedius induced cnsdc and autoantibody production. the present study was performed to verify the model by examining 1) the reappearance of the pbc-like cnsdc after lymphocyte transfer from model to naïve mice, 2) the involvement of autophagy, and 3) the influence of the strain difference. | 2012 | 22661269 |
| streptococcal infections in patients with chronic granulomatous disease: case report and review of the literature. | streptococcus intermedius caused a liver abscess in a patient with chronic granulomatous disease (cgd). in contrast to typical staphylococcal abscesses in cgd, this abscess was liquid, easily drained, and resolved without surgery or steroids. this case and literature review provide insight into this organism's pathogenesis, including in cgd. | 2012 | 22371289 |
| culture-negative brain abscess with streptococcus intermedius infection with diagnosis established by direct nucleotide sequence analysis of the 16s ribosomal rna gene. | a 70-year-old woman developed a headache for a month followed by right upper limb weakness. ct scan and mri showed multiple ring-enhancing lesions. an intracerebral aspiration of an abscess was performed, but culture results were negative. the nucleotide sequence analysis of the 16s rrna gene from the specimens identified streptococcus intermedius. given this result, s. intermedius was cultured by enrichment culture, and its sensitivities to antibiotics were determined. the patient exhibited com ... | 2012 | 22246493 |
| real-time monitoring of the adherence of streptococcus anginosus group bacteria to extracellular matrix decorin and biglycan proteoglycans in biofilm formation. | members of the streptococcus anginosus group (sags) are significant pathogens. however, their pathogenic mechanisms are incompletely understood. this study investigates the adherence of sags to the matrix proteoglycans decorin and biglycan of soft gingival and alveolar bone. recombinant chondroitin 4-sulphate(c4s)-conjugated decorin and biglycan were synthesised using mammalian expression systems. c4s-conjugated decorin/biglycan and dermatan sulphate (ds) decorin/biglycan were isolated from ovin ... | 2012 | 22835945 |
| lemierre's syndrome: rare, but life threatening-a case report with streptococcus intermedius. | lemierre's syndrome (ls) is a rare, but a life-threatening complication of an oropharyngeal infection. combinations of fever, pharyngitis, dysphagia, odynophagia, or oropharyngeal swelling are common presenting symptoms. infection of the lateral pharyngeal space may result in thrombosis of the internal jugular vein, subsequent metastatic complications (e.g., lung abscesses, septic arthritis), and significant morbidity and mortality. ls is usually caused by the gram-negative anaerobic bacillus fu ... | 2012 | 23197986 |
| comparison of oral microbiota in tumor and non-tumor tissues of patients with oral squamous cell carcinoma. | bacterial infections have been linked to malignancies due to their ability to induce chronic inflammation. we investigated the association of oral bacteria in oral squamous cell carcinoma (oscc/tumor) tissues and compared with adjacent non-tumor mucosa sampled 5 cm distant from the same patient (n = 10). by using culture-independent 16s rrna approaches, denaturing gradient gel electrophoresis (dgge) and cloning and sequencing, we assessed the total bacterial diversity in these clinical samples. | 2012 | 22817758 |
| impact of periodontal therapy on the subgingival microbiota of severe periodontitis: comparison between good responders and individuals with refractory periodontitis using the human oral microbe identification microarray. | this study compares the changes to the subgingival microbiota of individuals with "refractory" periodontitis (rp) or treatable periodontitis (good responders [gr]) before and after periodontal therapy by using the human oral microbe identification microarray (homim) analysis. | 2012 | 22324467 |
| [comparison of culture and real-time pcr methods in the detection of streptococcus pneumoniae and haemophilus influenzae in acute otitis media effusion specimens]. | streptococcus pneumoniae and haemophilus influenzae are the major etiologic agents of acute otitis media. this study was aimed to compare the detection rate of s.pneumoniae and h.influenzae by culture and real-time polymerase chain reaction (rt-pcr) in the middle ear effusions of patients diagnosed as acute otitis media. a total of 60 middle ear effusion samples collected from children with acute otitis media were included in the study. the samples were inoculated and incubated in bactec ped plu ... | 2012 | 23188581 |
| [analysis of diversity of vaginal microbiota in healthy chinese women by using dna-fingerprinting]. | to analyze the diversity of healthy women's vaginal dominant flora in different physiological states with pcr-denaturing gradient gel electrophoresis (pcr-dgge), to establish the basis for the future study of lower genital tract infections, and to provide a theoretical basis for the development of vaginal probiotics adapted to chinese females. | 2012 | 22517004 |
| bacteria and their toxins tamed for immunotherapy. | bacterial toxins share the ability to enter host cells to target various intracellular proteins and to modulate host immune responses. over the last 20 years, toxins and their mutated variants, as well as live attenuated bacteria, have been exploited for vaccination and immunotherapy of various infectious, malignant and autoimmune diseases. the ability of bordetella pertussis adenylate cyclase toxin to translocate its adenylate cyclase domain across the host cell membrane, as well as the pathway ... | 2012 | 22339216 |
| antibiotic effects on bacterial profile in osteonecrosis of the jaw. | oral diseases (2011) 18, 85-95 objective: oral infection is considered to play a critical role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (bronj), and antibiotic therapy has become a mainstay of bronj therapy. this study was aimed to investigate the effect of antibiotics on bacterial diversity in bronj tissues. materials and methods: the bacterial profile from soft tissues associated with the bronj lesion was determined using 16s rrna-based denaturing gradient gel e ... | 2012 | 21883710 |
| necrotizing periodontal diseases in hiv-infected brazilian patients: a clinical and microbiologic descriptive study. | objective: nowadays, necrotizing periodontal diseases have a low prevalence; however, a better understanding of the etiopathogenesis of these diseases is necessary for determining more adequate preventive and therapeutic strategies. method and materials: from a pool of 1,232 hiv-infected patients, 15 presented with necrotizing periodontal diseases, which were evaluated by full-mouth periodontal clinical measurements. subgingival biofilm samples were collected from necrotizing lesions of six of t ... | 2012 | 22259811 |