Publications

[the lazarević-lasègue sign].		2016	4919349
the anorectic effect of dexamphetamine sulphate.		2016	4882572
[pharmacodynamical diagnosis of heart defects in childhood using alupent].		2015	4663559
[nutrition from today to tomorrow. from today's new foods to the foods of the future, by radioconservation in passing].		2015	4736454
[in memoriam of assistant prof. otto saxl, m.d].		2015	4552006
microenvironment and phylogenetic diversity of prochloron inhabiting the surface of crustose didemnid ascidians.	the cyanobacterium prochloron didemni is primarily found in symbiotic relationships with various marine hosts such as ascidians and sponges. prochloron remains to be successfully cultivated outside of its host, which reflects a lack of knowledge of its unique ecophysiological requirements. we investigated the microenvironment and diversity of prochloron inhabiting the upper, exposed surface of didemnid ascidians, providing the first insights into this microhabitat. the ph and o2 concentration in ...	2015	26176189
methyl green-pyronin staining: effects of fixation; use in routine pathology.		2014	4109442
a hemodynamic comparison of young and older endurance athletes during exercise.	this study assessed the hemodynamic responses to exercise of master athletes (56 +/- 5 yr of age) who placed in the top 10% of their age groups in local 10-km competitive events, competitive young runners (26 +/- 3 yr), young runners matched in training and performance to the master athletes (25 +/- 3 yr), and healthy older sedentary subjects (58 +/- 5 yr). the maximal o2 consumption (vo2max) of the master athletes was 9 and 19% lower than that of the matched young and competitive young runners, ...	2014	4008419
letter: plasma arginine esterase activity in cystic fibrosis.		2014	4414342
[use of amido black for cytophotometric studies of cellular proteins].		2014	4113807
[an operative case of spermatic cord rhabdomyosarcoma--with a review of similar cases in japan].	a 17-year-old japanese boy was admitted with the complaint of painless, progressive enlargement of the left scrotal contents during the preceding two months. the tumor was firm and nontender without transillumination. orchitectomy with high ligatation of the spermatic cord was performed. the tumor, weighing 13.1 g, was gray, solid, located at the distal part of the spermatic cord, and separated from the testis and epididymis. the pathological diagnosis showed left spermatic cord rhabdomyosarcoma ...	2014	4079066
[clinical applications of monoclonal antibodies].		2013	3906817
[clinical applications of monoclonal antibodies].		2013	3906817
striving for excellence in medical education.		2013	3625746
[peridural analgesia with morphine in oncologic patients].		2013	3726634
late onset adrenomyeloneuropathy.		2013	3668578
[the newborn infant of the mother with essential arterial hypertension ].		2013	3954855
infection control in pulmonary function laboratories.		2013	3851785
structure of patf from prochloron didemni.	patellamides are macrocyclic peptides with potent biological effects and are a subset of the cyanobactins. cyanobactins are natural products that are produced by a series of enzymatic transformations and a common modification is the addition of a prenyl group. puzzlingly, the pathway for patellamides in prochloron didemni contains a gene, patf, with homology to prenylases, but patellamides are not themselves prenylated. the structure of the protein patf was cloned, expressed, purified and determ ...	2013	23722837
excitation energy relaxation in a symbiotic cyanobacterium, prochloron didemni, occurring in coral-reef ascidians, and in a free-living cyanobacterium, prochlorothrix hollandica.	the marine cyanobacterium prochloron is a unique photosynthetic organism that lives in obligate symbiosis with colonial ascidians. we compared prochloron harbored in four different host species and cultured prochlorothrix by means of spectroscopic measurements, including time-resolved fluorescence, to investigate host-induced differences in light-harvesting strategies between the cyanobacteria. the light-harvesting efficiency of photosystems including antenna pcb, ps ii-ps i connection, and pigm ...	2012	22728755
microenvironmental ecology of the chlorophyll b-containing symbiotic cyanobacterium prochloron in the didemnid ascidian lissoclinum patella.	the discovery of the cyanobacterium prochloron was the first finding of a bacterial oxyphototroph with chlorophyll (chl) b, in addition to chl a. it was first described as prochloron didemni but a number of clades have since been described. prochloron is a conspicuously large (7-25 μm) unicellular cyanobacterium living in a symbiotic relationship, primarily with (sub-) tropical didemnid ascidians; it has resisted numerous cultivation attempts and appears truly obligatory symbiotic. recently, a p ...	2012	23226144
primary pulmonary amyloidosis. an unusual case with 14 years' survival.	a 70-year-old woman had nodular lesions and a right hilar infiltrate visible on chest x-ray film. the diagnosis of pulmonary amyloidosis was established by a transbronchial lung biopsy. over the next 14 years, the patient remained relatively asymptomatic but developed extensive pulmonary involvement. the case illustrates the long and relatively benign course of primary pulmonary amyloidosis.	2012	3709256
rcts revisited.		2011	3205244
morbidity and mortality of asthma.	morbidity and mortality of asthma has been on the upswing since the 1960s, as marked by increased hospitalizations with asthma since the early 1980s. this has not been explained adequately. the possibility of change in the natural history or increased exposure to environmental irritant chemicals or allergens has been suggested by some. there probably has been better recognition and diagnosis of asthma by distinguishing it from bronchitis, recurrent croup, and bronchiolitis in children. despite e ...	2011	3174269
variation in tropical reef symbiont metagenomes defined by secondary metabolism.	the complex evolution of secondary metabolism is important in biology, drug development, and synthetic biology. to examine this problem at a fine scale, we compared the genomes and chemistry of 24 strains of uncultivated cyanobacteria, prochloron didemni, that live symbiotically with tropical ascidians and that produce natural products isolated from the animals. although several animal species were obtained along a >5500 km transect of the pacific ocean, p. didemni strains are >97% identical acr ...	2011	21445351
[effects of the decisions of the nursing legislation from 4 june 1985 on nursing and hospitals].		2011	3119926
Complex microbiome underlying secondary and primary metabolism in the tunicate-Prochloron symbiosis.	The relationship between tunicates and the uncultivated cyanobacterium Prochloron didemni has long provided a model symbiosis. P. didemni is required for survival of animals such as Lissoclinum patella and also makes secondary metabolites of pharmaceutical interest. Here, we present the metagenomes, chemistry, and microbiomes of four related L. patella tunicate samples from a wide geographical range of the tropical Pacific. The remarkably similar P. didemni genomes are the most complex so far as ...	2011	22123943
the control of carotid arterial haemorrhage in head and neck surgery by balloon catheter tamponade and detachable balloon embolisation.	radical surgery in the neck is hazardous after irradiation. rupture of the carotid artery may lead to uncontrollable haemorrhage. reported mortality rates following this serious complication are between 18% and 50% (heller and strong, 1979). we describe a simple method for controlling acute carotid haemorrhage using a standard fogarty biliary catheter, with selective detachable balloon embolisation for permanent occlusion of the carotid artery.	2011	3947797
investigations into the sequence-selective binding of mithramycin and related ligands to dna.	the preferred binding sites for mithramycin on four different dna fragments have been investigated by dnaase i footprinting. sites containing at least two contiguous gc base pairs are protected by the antibiotic, the preferred binding site consisting of the dinucleotide step gpg (or cpc). related antibiotics chromomycin and olivomycin produce similar, but not identical footprinting patterns suggesting that they can recognize other sequences as well. all three antibiotics induce enhanced rates of ...	2010	2934687
preventing blindness: a lot more than meets the eye.		2010	4497553
emission tomography with 99mtc-pyrophosphate in the diagnosis of acute myocardial infarction.	electrocardiograms (ecg) and enzyme criteria are usually used to confirm the diagnosis of acute myocardial infarction in the case of chest pain. however, ecg is not always diagnostic. elevated enzyme values may be due to causes other than myocardial infarction. in uncertain cases, the ecg and enzyme criteria can be supplemented by emission tomography, performed with technetium pyrophosphate that will accumulate in the site of infarction. twenty-nine patients with suspected acute myocardial infar ...	2010	2992989
nitrous oxide and day-case laparoscopy: effects on nausea, vomiting and return to normal activity.	patients admitted for day-case laparoscopy were assigned randomly to receive nitrous oxide-oxygen or oxygen, with enflurane, during a standard anaesthetic technique. postoperative morbidity, in particular nausea and vomiting, and ability to resume normal activity were assessed over the ensuing 48 h. supplementary administration of propofol during the operative procedure was required significantly more often (p less than 0.05) in the absence of nitrous oxide. there was no significant difference i ...	2010	2967712
aids publicity: some experiences from scotland.		2010	3101795
increased proportion of proapolipoprotein a-i in hdl from patients with liver cirrhosis and hepatitis.	we examined the isoform pattern of apolipoprotein a-i (apo a-i) in high density lipoprotein from patients with liver disease. an increase in the proportion of proapo a-i was evident in patients with decompensated liver cirrhosis, acute hepatitis and hepatocellular carcinoma. the rate of conversion from proapo a-i to apo a-i was low in sera from those with liver disease, compared to normal controls. the proportion of proapo a-i showed a tendency toward increase with advance in liver damage. these ...	2009	2846400
electrotherapy and hyperbaric oxygen: promising treatments for postradiation complications.	electrotherapy and hyperbaric oxygen therapy have been added to physical therapy to treat patients with postsurgery and radiation sequelae. problems of reduced oral opening and range of head movement, soft tissue necrosis, osteoradionecrosis, and delayed wound healing were addressed in 37 patients over a 3-year period. of this group, 16 irradiated maxillary resection patients were specifically followed up to determine the effectiveness of the new modalities on improving reduced oral opening. alt ...	2009	2810138
primary meningeal melanoma.		2009	2706127
angiodysplasia as a cause of iron deficiency anaemia.	angiodysplasia, a condition of unknown aetiology, is thought to represent the commonest cause of obscure gastrointestinal bleeding, particularly in the elderly population. the lesions of angiodysplasia, which are small (less than 5 mm) and usually multiple, consist of microvascular abnormalities in the mucosa and submucosa of the bowel wall. they are most commonly found in the caecum and right side of the colon, but have been observed in the stomach, ileum and elsewhere in the colon. the diagnos ...	2009	2676033
membrane effects of the polyene antibiotic amphotericin b and of some of its derivatives on lymphocytes.	amphotericin b (amb) exhibits immunomodulating properties in mice. in vitro studies on lymphocytes, in relation with these properties, are reported here with amb and two of its derivatives: the n-fructosyl (n-fru amb) and the n-thiopropionyl (ambsh) derivatives. interactions of these molecules with thymocytes, a sensitive cell type, demonstrated that the extent of binding is not a toxicity parameter. in contrast, membrane fluidity changes have been observed and appeared to be related to toxicity ...	2009	2695832
intracerebroventricular n-ethylmaleimide differentially reduces supraspinal opioid analgesia in mice.	i.c.v. injection of 1 nmol n-ethylmaleimide (nem) into mice interfered with opioid-induced supraspinal analgesia, as assessed in the warm water tail-flick test. this effect of nem was long-lasting (more than 3 days), non-competitive and differentially inhibited by the opioids studied. the analgesia induced by [d-ala2,d-leu5]enkephalin (dadle), [d-ala2,met5]enkephalinamide (dame) and [d-pen2,d-pen5]enkephalin (dpdpe) was greatly reduced in nem-treated mice. the antinociception elicited by [d-ala2 ...	2009	2676563
lamp-1 in cho cells is a primary carrier of poly-n-acetyllactosamine chains and is bound preferentially by a mammalian s-type lectin.	recent studies indicate that some mammalian s-type lectins bind preferentially to oligosaccharides containing the repeating disaccharide [3gal beta 1,4glcnac beta 1]n or poly-n-acetyllactosamine (pl) sequence. we report here our investigation on the distribution of these sequences in glycoproteins in chinese hamster ovary (cho) cells and the interaction of glycoproteins containing pl chains with an immobilized s-type lectin (l14) from calf heart tissue. our results demonstrate that pl chains are ...	2008	2268316
residual stress in several ceramometal systems.	residual stress caused by a mismatch of alloy-porcelain thermal contraction can contribute to clinical failure of a ceramometal restoration. this investigation assessed thermal compatibility of three ceramometal alloys and two opaque porcelains. thermal expansions of the alloys and porcelains were measured by using a straight push-rod dilatometer. porcelain glass transition temperatures and expansion values were derived from length-versus-temperature curves. residual stress states in alloy-porce ...	2008	2810135
[aseptic loosening of endoprosthesis using various sorts of metals].		2008	4096709
oral morphine for pain control in cancer patients.		2008	2441476
exploring subjective vs. objective issues in the validation of computer-based critiquing advice.	evaluation is an important part of the development of computer-based medical expert systems. such evaluation may be particularly difficult when judging a critiquing system which responds to a proposed management strategy with a discussion of the advisability of that approach. dxcon is an expert system which produces a prose critique discussing the radiologic workup of obstructive jaundice. this paper describes dxcon, and its experimental validation by three independent judges. a central componen ...	2008	2311365
a mucin containing the x, y, and h type 2 carbohydrate determinants is shed by carcinoma cells.	monoclonal antibody br 15-6a directed to the y carbohydrate determinant (fuc alpha 1----2gal beta 1----4glcnac(3----1fuc) beta 1----3gal beta 1----4glc beta 1----1cer) reacted with the cell surface and conditioned media of colorectal and breast carcinoma cell lines. double determinant immunoassays using br 15-6a as detector antibody showed that the y determinant is part of a high molecular weight mucin that coexpressed other carbohydrate antigens based on a type 2 chain (x, h type 2). type 1 cha ...	2008	2442094
identifying bacterial genes and endosymbiont dna with glimmer.	the glimmer gene-finding software has been successfully used for finding genes in bacteria, archaea and viruses representing hundreds of species. we describe several major changes to the glimmer system, including improved methods for identifying both coding regions and start codons. we also describe a new module of glimmer that can distinguish host and endosymbiont dna. this module was developed in response to the discovery that eukaryotic genome sequencing projects sometimes inadvertently captu ...	2007	17237039
the mhc-binding and gp120-binding functions of cd4 are separable.		2007	2387122
psoas abscess localization by gallium scan in aplastic anemia.	gallium 67 scanning is an effective method of detecting inflammatory lesions, especially abscesses. a 10-year-old boy with aplastic anemia and severe leukopenia and granulocytopenia had a psoas abscess diagnosed by gallium scan. the patient died with candida spesis 18 days after bone marrow transplantation. at autopsy, a chronic psoas abscess with candida was found. the gallium scan offers a clinically effective and noninvasive means of evaluating suspected infection in the granulocytopenic pati ...	2005	1091749
baillière tindall prizewinner .1. the clinical nurse consultant.		2005	1129151
unique origin and lateral transfer of prokaryotic chlorophyll-b and chlorophyll-d light-harvesting systems.	pcb genes, encoding proteins binding light-harvesting chlorophylls, were cloned and sequenced from the chl d-containing cyanobacterium, acaryochloris marina, and the chl b-containing cyanobacterium, prochloron didemni. both organisms contained two tandem pcb genes. peptide fingerprinting confirmed the expression of one of the a. marina pcb genes. phylogenetic tree reconstruction using distance-matrix and maximum-likelihood methods indicated a single origin of the pcb gene family, whether occurri ...	2005	15356274
patellamide a and c biosynthesis by a microcin-like pathway in prochloron didemni, the cyanobacterial symbiont of lissoclinum patella.	prochloron spp. are obligate cyanobacterial symbionts of many didemnid family ascidians. it has been proposed that the cyclic peptides of the patellamide class found in didemnid extracts are synthesized by prochloron spp., but studies in which host and symbiont cells are separated and chemically analyzed to identify the biosynthetic source have yielded inconclusive results. as part of the prochloron didemni sequencing project, we identified patellamide biosynthetic genes and confirmed their func ...	2005	15883371
structure of a photosystem ii supercomplex isolated from prochloron didemni retaining its chlorophyll a/b light-harvesting system.	prochlorophytes are a class of cyanobacteria that do not use phycobiliproteins as light-harvesting systems, but contain chlorophyll (chl) a/b-binding pcb proteins. recently it was shown that pcb proteins form an 18-subunit light-harvesting antenna ring around the photosystem i (psi) trimeric reaction center complex of the prochlorophyte prochlorococcus marinus ss120. here we have investigated whether the symbiotic prochlorophyte prochloron didemni also contains the same supermolecular complex. u ...	2003	12837938
[anterior antehypaphyseal insufficiecency in the elderly].	the authors report 4 personal cases, and analyse 18 cases of anterior pituitary insufficiency in the elderly found in the world literature. the initial symptoms are not specific and are difficult to interpret. they are frequently attributed to physiological ageing. in the absence of early diagnois, the patient may become comatose, this coma is often irreversible in spite of hormone treatment. in 60% of cases, the cause of the pituitary failure was not found. in the onset of the latter, the role ...	2003	166436
glyceraldehyde-3-phosphate dehydrogenase gene diversity in eubacteria and eukaryotes: evidence for intra- and inter-kingdom gene transfer.	cyanobacteria contain up to three highly divergent glyceraldehyde-3-phosphate dehydrogenase (gapdh) genes: gap1, gap2, and gap3. genes gap1 and gap2 are closely related at the sequence level to the nuclear genes encoding cytosolic and chloroplast gapdh of higher plants and have recently been shown to play distinct key roles in catabolic and anabolic carbon flow, respectively, of the unicellular cyanobacterium synechocystis sp. pcc6803. in the present study, sequences of 10 gapdh genes distribute ...	1999	10331270
isolation and characterisation of oxygen evolving thylakoids from the marine prokaryote prochloron didemni.	the present study describes the first successful attempt to isolate oxygen evolving thylakoids and thylakoid fragments from the marine prokaryote prochloron didemni, a member of the recently discovered group of prochlorophytes. oxygen evolving thylakoid membranes and fragments were isolated from seawater suspended cells of prochloron didemni by passage of the cells through a yeda press and subsequent differential centrifugation of the broken material. three fractions were collected at 1000 x g, ...	1999	10338145
chlorophyll b and phycobilins in the common ancestor of cyanobacteria and chloroplasts.	photosynthetic organisms have a variety of accessory pigments, on which their classification has been based. despite this variation, it is generally accepted that all chloroplasts are derived from a single cyanobacterial ancestor. how the pigment diversity has arisen is the key to revealing their evolutionary history. prochlorophytes are prokaryotes which perform oxygenic photosynthesis using chlorophyll b, like land plants and green algae (chlorophyta), and were proposed to be the ancestors of ...	1999	10408441
sequence of prochloron didemni atpbe and the inference of chloroplast origins.	the prochlorophytes, oxygenic photosynthetic prokaryotes containing chlorophylls a and b, have been put forward as descended from the organisms that gave rise to chloroplasts of green plants and algae by endosymbiosis, although this has always been controversial. to assess the phylogenetic position of the prochlorophyte prochloron didemni, we have cloned and sequenced its atpbe genes. phylogenetic inference under a range of models gives moderate to strong support for a cyanobacterial grouping ra ...	1992	1532658
htlv-1 polymyositis in a patient also infected with the human immunodeficiency virus.		1990	2311349
nonacylated human transferrin receptors are rapidly internalized and mediate iron uptake.	the human transferrin receptor is post-translationally modified by the addition of a fatty acyl moiety. in earlier studies, transient expression in cos cells of human transferrin receptors in which cys62 or cys67 was altered to serine provided evidence that cys62 is the major acylation site of the receptor (jing, s., and trowbridge, i. s. (1987) embo j. 6, 327-331). to determine whether acylation of the receptor is required for high efficiency endocytosis and iron uptake, wild type and mutant hu ...	1990	2365686
late appearance of phospholipid platelet-activating factor and leukotriene b4 in human skin after repeated antigen challenge.	inflammatory mediators were assessed in supernatants of chamber fluids from eight ragweed- or grass-sensitive subjects during antigen-induced cutaneous inflammatory responses. platelet activating factor (paf) accumulated at concentrations of 1 pm to 90 mumol/l in six of eight subjects beginning at 3 hours and continuing for 9 hours after antigen challenge. leukotriene b4 (ltb4) was detectable at cutaneous sites of antigen challenge in five of five subjects throughout the 9-hour period at levels ...	1989	2538500
serum igg level against streptococcus mutans in subjects with caries experience.	serum igg level against streptococcus mutans serotype c was studied in 33 subjects, in relation to dental caries, oral hygiene and age. the activity of the serum igg against the sonicated antigens of the bacterium was evaluated by micro-elisa. the serum igg titer to s. mutans was significantly higher in the subjects with no detectable carious lesions than in the subjects with active caries (p less than 0.05). however, there was no clear difference between the serum igg antibody to s. mutans and ...	1989	2632131
[synthetic cephalosporins. v. synthesis and antibacterial activity of 3-alkylthio-7 beta-[(z)-2-(2-aminothiazol-4-yl)-2-(o-substituted oxyimino)acetamido]cephalosporins and related compounds].	3-alkylthio-7 beta-[(z)-2-(2-aminothiazol-4-yl)-2-(o-substituted oxyimino)acetamido]cephalosporins (6 and 7) and the 3-methoxy analogues (10) were prepared by coupling diphenylmethyl 7-amino-3-alkylthio-3-cephem-4-carboxylate (1 and 2) or diphenylmethyl 7-amino-3-methoxy-3-cephem-4-carboxylate with (z)-2-(2-tritylaminothiazol-4-yl)-2-(o-substituted oxyimino)acetic acid (4), followed by deprotection and subjected to examination of antibacterial activities. the pivaloyloxymethyl esters (8 and 9) o ...	1989	2698417
the relationship of a prochlorophyte prochlorothrix hollandica to green chloroplasts.	it is generally accepted that chloroplasts arose from one or more endosymbiotic events between an ancestral cyanobacterium and a eukaryote. such an origin fits well in the case of the chloroplasts of rhodophytes that, like cyanobacteria, contain chlorophyll a and phycobilin pigments. the green chloroplasts from higher plants, green algae, and euglenoids however, contain chlorophyll b as well as chlorophyll a, and lack phycobilins. consequently, it has been suggested that they arose independently ...	1989	2911389
fetal choroid plexus lesions. relationship of antenatal sonographic appearance to clinical outcome.	the sonograms and clinical outcomes of 31 fetuses with antenatally detected choroid plexus lesions were retrospectively reviewed. lesions were classified as simple cysts in 22 cases (71%) and complex lesions in 9 (29%). simple cysts tended to be smaller in size than the complex lesions and no adverse sequelae were attributed to the sonographic detection of simple cysts. although complex choroid plexus lesions appeared to be an incidental finding in seven of nine cases (78%), one of the remaining ...	1989	2651694
human and rabbit newborn lung macrophages have reduced anti-candida activity.	bronchoalveolar macrophages (bam) protect the adult lung from low level microbial contamination. the antimicrobial activity of human newborn bam is unknown. bam were isolated from effluents of suctioned, intubated newborns and from bronchoalveolar lavage of healthy, nonsmoking adult volunteers. an in vitro cytologic slide assay was developed and used to ascertain: 1) inhibition of intracellular filamentation of candida albicans (active yeast growth) and 2) killing + digestion of ingested c. albi ...	1988	3062557
prophylactic parenteral antibiotics in clean neurosurgical procedures: a review.	clean surgical procedures carry a risk of postoperative wound infection that is less than 5% in most hospitals. the use of prophylactic antibiotic agents in clean neurosurgical cases is controversial, and the neurosurgical literature through 1980 contains no controlled clinical trials to study its effectiveness in such cases. a report of 1732 consecutive procedures without a single postoperative wound infection in patients receiving systemic gentamicin, vancomycin, and streptomycin irrigation fl ...	1988	3288725
[quantitative estimation of synaptic acetylcholinesterase inhibition with galanthamine using parameters of miniature endplate currents].	miniature end-plate currents (mepc) were recorded in voltage clamped muscle fibers of the rat diaphragm at different degrees of acetylcholinesterase (ache) inhibition with galanthamine. a model has been suggested connecting the increase in mepc amplitude with the concentration of a competitive reversible ache inhibitor. using the model suggested, the changes in the junctional ache activity inhibited with different concentrations of galanthamine were estimated. the calculated value of the inhibit ...	1988	3390582
redifferentiation and subsequent dedifferentiation of the livers of roosters resulting from acute estrogen challenges.	1. histologic and metabolic changes take place in livers of rooster receiving challenges consisting of acute doses of estrone. 2. during initial growth and redifferentiation livers rapidly increase in size by division of hepatocytes within most lobules, changing from cordlike to acinar configurations. 3. no new lobules appear and degeneration of some cells within lobules takes place even as cell divisions predominate. 4. cells within lobules assume secretory features. 5. vitellogenins, very low ...	1987	2887384
products of lipolysis in human milk destroy parasites.		1987	3306484
biologically active derivatives of gossypol: synthesis and antimalarial activities of peri-acylated gossylic nitriles.	a series of peri-acylated gossylic nitriles were synthesized from gossypol dioxime by treatment of the dioxime with the appropriate acid anhydride and its salt. the reaction pathway was elucidated by isolation and characterization of intermediates. peri-acylated gossylic nitriles (acyl = acetyl, propionyl, butyryl, and valeryl) were compared with gossypol for activity against both chloroquine-sensitive and chloroquine-resistant strains of plasmodium falciparum. the gossylic nitriles all retain a ...	1986	3528492
attempts to modify changes in the piglet small intestine after weaning.	the possible causes of changes in the piglet small intestine after weaning were investigated. groups of piglets weaned at three weeks old were either given oral oxytetracycline daily, weaned on to a regularly fed sow-milk replacer or weaned on to specially formulated diets based on casein or hydrolysed casein as the protein source. after five days, changes in small intestinal structure and brush-border enzyme activities were compared with previous findings in weaned and unweaned animals of the s ...	1986	3090663
attempts to modify changes in the piglet small intestine after weaning.	the possible causes of changes in the piglet small intestine after weaning were investigated. groups of piglets weaned at three weeks old were either given oral oxytetracycline daily, weaned on to a regularly fed sow-milk replacer or weaned on to specially formulated diets based on casein or hydrolysed casein as the protein source. after five days, changes in small intestinal structure and brush-border enzyme activities were compared with previous findings in weaned and unweaned animals of the s ...	1986	3090663
t helper and t suppressor cells are restricted by the a and e molecules, respectively, in the f antigen system.	the role of the a and e molecules as restriction elements was examined in the f antigen system. in the mouse the only responder haplotype known to date is k, and blocking studies with a monoclonal antibody show that in vitro t-cell proliferation is restricted by the ak molecule. the (cba x dba/2)f1 hybrid, which is a responder x nonresponder cross, is itself a nonresponder in terms of f-specific antibody production. up to 10 days after priming, (cba x dba/2)f1 t cells exhibited an f-specific pro ...	1985	3161822
hypotensive effects after topical and intra-arterial administration of alpha-adrenergic agonists in isolated perfused rabbit eyes.	the influence of nonselective and selective alpha-adrenergic agonists on intraocular pressure (iop) was studied in isolated arterially perfused rabbit eyes. drugs were given intra-arterially or topically. with either route of administration, no initial hypertensive phase was observed after l-epinephrine, l-norepinephrine, l-phenylephrine (alpha 1), or methoxamine (alpha 1), but there was an immediate ocular hypotensive effect. the alpha 2-agonist b-ht 920 caused a nonsignificant 1 mm hg fall in ...	1985	2866480
biochemical and molecular epidemiology of human cancer risk.		1985	3903477
dose-dependent effect of calcium and magnesium etidronate on salicylic acid absorption in the rat.	disodium etidronate affected salicylic acid absorption from the rat small intestine, in-situ, when instilled into a jejunal segment for different exposure times before the salicylic acid absorption was measured. at low etidronate concentrations and short exposure times, the salicylic acid absorption rate was significantly increased compared with saline controls. at high etidronate concentrations and longer exposure times, the absorption rate was reduced. etidronate precomplexed with calcium or m ...	1985	2862271
ribulose 1,5-bisphosphate carboxylase and phosphoribulokinase in prochloron.	cell-free extracts of prochloron didemni were assayed for ribulose 1,5-bisphosphate (rubp) carboxylase (ec 4.1.1.39) and phosphoribulokinase (ec 2.7.1.19), two key enzymes in the reductive pentose-phosphate cycle. in an rubp-dependent reaction, the production of two molecules of 3-phosphoglycerate per molecule of co2 fixed was shown. phosphoribulokinase activity was demonstrated by the production of adp from ribulose 5-phosphate (ru5p) and atp and by measurement of atp-, ru5p-dependent (14)co2 f ...	1983	24264746
regulatory proteins of lobster striated muscle.	the regulatory proteins of lobster muscles consist of tropomyosin and of troponin. troponin contains a 17,000 chain weight component, two closely related components of about 30,000 and a 52,000 chain weight component. in addition to troponin, tropomyosin is required for the inhibition of the magnesium activated actomyosin atpase activity in the absence of calcium and for the reversal of this inhibition by calcium. lobster tropomyosin interacts with rabbit actin and lobster troponin interacts wit ...	1975	123757
a sodium-dependent sugar co-transport system in bacteria.		1971	4940369
inhibition of rna and protein synthesis in granular cells by actinomycin-d and puromycin.		1971	4104138
[epidemiological analysis of japanese encephalitis. statistics collected in miyagi prefecture in the last 5 years].		1969	4390886
a correlation between urinary steroid metabolites and pathways of steroidogenesis in human breast-tumour tissue.		1968	4176947