Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| we are not alone: a case for the human microbiome in extra intestinal diseases. | "dysbiosis" in the gut microbiome has been implicated in auto-immune diseases, in inflammatory diseases, in some cancers and mental disorders. the challenge is to unravel the cellular and molecular basis of dysbiosis so as to understand the disease manifestation. | 2017 | 28286571 |
| association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. | the pathway leading from amyloid-β deposition to cognitive impairment is believed to be a cornerstone of the pathogenesis of alzheimer's disease (ad). however, what drives amyloid buildup in sporadic nongenetic cases of ad is still unknown. ad brains feature an inflammatory reaction around amyloid plaques, and a specific subset of the gut microbiota (gmb) may promote brain inflammation. we investigated the possible role of the gmb in ad pathogenesis by studying the association of brain amyloidos ... | 2017 | 27776263 |
| profiling living bacteria informs preparation of fecal microbiota transplantations. | fecal microbiota transplantation is a compelling treatment for recurrent clostridium difficile infections, with potential applications against other diseases associated with changes in gut microbiota. but variability in fecal bacterial communities-believed to be the therapeutic agent-can complicate or undermine treatment efficacy. to understand the effects of transplant preparation methods on living fecal microbial communities, we applied a dna-sequencing method (pma-seq) that uses propidium mon ... | 2017 | 28125667 |
| relative abundance in bacterial and fungal gut microbes in obese children: a case control study. | differences in relative proportions of gut microbial communities in adults have been correlated with intestinal diseases and obesity. in this study we evaluated the gut microbiota biodiversity, both bacterial and fungal, in obese and normal-weight school-aged children. | 2017 | 27007700 |
| oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with ibd. | iron deficiency is a common complication in patients with ibd and oral iron therapy is suggested to exacerbate ibd symptoms. we performed an open-labelled clinical trial to compare the effects of per oral (po) versus intravenous (iv) iron replacement therapy (irt). | 2017 | 26848182 |
| short-term impact of a classical ketogenic diet on gut microbiota in glut1 deficiency syndrome: a 3-month prospective observational study. | the classical ketogenic diet (kd) is a high-fat, very low-carbohydrate normocaloric diet used for drug-resistant epilepsy and glucose transporter 1 deficiency syndrome (glut1 ds). in animal models, high fat diet induces large alterations in microbiota producing deleterious effects on gut health. we carried out a pilot study on patients treated with kd comparing their microbiota composition before and after three months on the diet. | 2017 | 28361745 |
| anaerobic bacteria in the intestinal microbiota of brazilian children. | changes in the neonatal gut environment allow for the colonization of the mucin layer and lumen by anaerobic bacteria. the aim of the present study was to evaluate bifidobacterium, lactobacillus and lactococcus colonization through the first year of life in a group of 12 brazilian infants and to correlate these data with the levels of escherichia coli. the presence of anaerobic members of the adult intestinal microbiota, including eubacterium limosum and faecalibacterium prausnitzii, was also ev ... | 2017 | 28355361 |
| altered molecular signature of intestinal microbiota in irritable bowel syndrome patients compared with healthy controls: a systematic review and meta-analysis. | many studies have reported significant changes in intestinal microbiota in irritable bowel syndrome (ibs) patients based on quantitative real-time pcr analysis. | 2017 | 28179092 |
| altered intestinal microbiota in patients with chronic pancreatitis: implications in diabetes and metabolic abnormalities. | intestinal dysbiosis and its functional implications in chronic pancreatitis (cp) have not been elaborately studied. we evaluated the taxonomic and functional alterations in intestinal microbiota in 30 well-characterised patients with cp (16 without, 14 with diabetes) and 10 healthy controls. the patients with cp and diabetes had significantly longer disease duration and greater degree of malnutrition. there was increase in plasma endotoxin concentrations from controls to cp non-diabetics to cp ... | 2017 | 28255158 |
| pili-like proteins of akkermansia muciniphila modulate host immune responses and gut barrier function. | gut barrier function is key in maintaining a balanced response between the host and its microbiome. the microbiota can modulate changes in gut barrier as well as metabolic and inflammatory responses. this highly complex system involves numerous microbiota-derived factors. the gut symbiont akkermansia muciniphila is positively correlated with a lean phenotype, reduced body weight gain, amelioration of metabolic responses and restoration of gut barrier function by modulation of mucus layer thickne ... | 2017 | 28249045 |
| effects of supernatants from escherichia coli nissle 1917 and faecalibacterium prausnitzii on intestinal epithelial cells and a rat model of 5-fluorouracil-induced mucositis. | faecalibacterium prausnitzii (fp) and escherichia coli nissle 1917 (ecn) are probiotics, which have been reported to ameliorate certain gastrointestinal disorders. we evaluated the effects of supernatants (sn) derived from fp and ecn on 5-fluorouracil (5-fu)-treated intestinal cells and in a rat model of mucositis. in vitro: iec-6, caco-2, and t-84 cells were analyzed for viability and monolayer permeability. in vivo: female dark agouti rats were gavaged with fp or ecn sn and injected intraperit ... | 2017 | 28094590 |
| gut microbiota differs between children with inflammatory bowel disease and healthy siblings in taxonomic and functional composition: a metagenomic analysis. | current treatment for pediatric inflammatory bowel disease (ibd) patients is often ineffective, with serious side effects. manipulating the gut microbiota via fecal microbiota transplantation (fmt) is an emerging treatment approach but remains controversial. we aimed to assess the composition of the fecal microbiome through a comparison of pediatric ibd patients to their healthy siblings, evaluating risks and prospects for fmt in this setting. a case-control (sibling) study was conducted analyzi ... | 2017 | 28039159 |
| baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab. | 2017 | 28368458 | |
| fecal bacterial communities in treated hiv infected individuals on two antiretroviral regimens. | intestinal microbiome changes that occur in hiv positive individuals on different antiretroviral therapy (art) regimens are important to understand, as they are potentially linked with chronic inflammation and microbiome-linked comorbidities that occur at increased incidence in this population. we conducted a cross-sectional study comparing the fecal microbiomes of hiv-uninfected (hiv sn) to hiv-infected individuals on long-term art (hiv+ ltart) from mexico using 16s ribosomal rna (16srna) targe ... | 2017 | 28262770 |
| metabolic adaptation to the aqueous leaf extract of moringa oleifera lam.-supplemented diet is related to the modulation of gut microbiota in mice. | the aqueous leaf extract of moringa oleifera lam. (lm-a) is reported to have many health beneficial bioactivities and no obvious toxicity, but have mild adverse effects. little is known about the mechanism of these reported adverse effects. notably, there has been no report about the influence of lm-a on intestinal microecology. in this study, animal experiments were performed to explore the relationships between metabolic adaptation to an lm-a-supplemented diet and gut microbiota changes. after ... | 2017 | 28382453 |
| enterococcus durans ep1 a promising anti-inflammatory probiotic able to stimulate siga and to increase faecalibacterium prausnitzii abundance. | enterococcus species, principally enterococcus faecium are used as probiotics since a long time with preference in animal applications but safety considerations were updated and also new uses as probiotics can be envisaged. fifteen enterococcus strains isolated from different foods were identified and analyzed for virulence factors and antibiotic resistance. three enterococcus durans strains were selected to study their immunomodulatory properties on pbmc and caco2 cells. two strains presented a ... | 2017 | 28239378 |
| the gut microbiota of siblings offers insights into microbial pathogenesis of inflammatory bowel disease. | siblings of patients with crohn's disease (cd) have elevated risk of developing cd and display aspects of disease phenotype, including faecal dysbiosis. in our recent article we have used 16s rrna gene targeted high-throughput sequencing to comprehensively characterize the mucosal microbiota in healthy siblings of cd patients, and determine the influence of genotypic and phenotypic factors on the gut microbiota (dysbiosis). we have demonstrated that the core microbiota of both patients with cd a ... | 2017 | 28112583 |
| intestinal proportion of blautia sp. is associated with clinical stage and histoprognostic grade in patients with early-stage breast cancer. | improving knowledge about breast cancer etiology is crucial in order to propose prevention strategies for this pathology. gut microbiota is involved in numerous physiopathological situations including cancers. although its potential involvement in breast cancer through the alteration of the enterohepatic circulation of estrogens and/or the metabolism of phytoestrogens has been discussed for some time, it remains to be demonstrated. the present study seeks to strengthen this hypothesis by identif ... | 2017 | 28094541 |
| faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics. | there is an increasing interest in faecalibacterium prausnitzii, one of the most abundant bacterial species found in the gut, given its potentially important role in promoting gut health. although some studies have phenotypically characterized strains of this species, it remains a challenge to determine which factors have a key role in maintaining the abundance of this bacterium in the gut. besides, phylogenetic analysis has shown that at least two different f. prausnitzii phylogroups can be fou ... | 2017 | 28045459 |
| adherence to a mediterranean diet influences the fecal metabolic profile of microbial-derived phenolics in a spanish cohort of middle-age and older people. | despite the evidence regarding the influence of certain polyphenol food sources on the metabolic profile in feces, the association between the different phenolics provided by the diet and the fecal phenolic profile has not been elucidated. in this study, the composition of phenolic metabolites in fecal solutions was analyzed by uplc-esi-ms/ms in 74 volunteers. this fecal phenolic profile showed a high interindividual variation of the different compounds analyzed, phenylacetic and phenylpropionic ... | 2017 | 28029051 |
| mucosa-associated biohydrogenating microbes protect the simulated colon microbiome from stress associated with high concentrations of poly-unsaturated fat. | polyunsaturated fatty acids (pufas) may affect colon microbiome homeostasis by exerting (specific) antimicrobial effects and/or interfering with mucosal biofilm formation at the gut mucosal interface. we used standardized batch incubations and the mucosal-simulator of the human microbial intestinal ecosystem (m-shime) to show the in vitro luminal and mucosal effects of the main pufa in the western diet, linoleic acid (la). high concentrations of la were found to decrease butyrate production and ... | 2017 | 27883264 |
| in vitro fermentation of b-gos: impact on faecal bacterial populations and metabolic activity in autistic and non-autistic children. | children with autism spectrum disorders (asd) often suffer gastrointestinal problems consistent with imbalances in the gut microbial population. treatment with antibiotics or pro/prebiotics has been postulated to regulate microbiota and improve gut symptoms, but there is a lack of evidence for such approaches, especially for prebiotics. this study assessed the influence of a prebiotic galactooligosaccharide (b-gos) on gut microbial ecology and metabolic function using faecal samples from autisti ... | 2017 | 27856622 |
| effects of varying dietary content of fermentable short-chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome. | a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (fodmaps) is increasingly recommended for patients with irritable bowel syndrome (ibs). we aimed to investigate the effects of a blinded low-fodmap vs high-fructo-oligosaccharides (fos) diet on symptoms, immune activation, gut microbiota composition, and short-chain fatty acids (scfas). | 2017 | 27747984 |
| differences in gut microbiota profile between women with active lifestyle and sedentary women. | physical exercise is a tool to prevent and treat some of the chronic diseases affecting the world's population. a mechanism through which exercise could exert beneficial effects in the body is by provoking alterations to the gut microbiota, an environmental factor that in recent years has been associated with numerous chronic diseases. here we show that physical exercise performed by women to at least the degree recommended by the world health organization can modify the composition of gut micro ... | 2017 | 28187199 |
| the association of specific constituents of the fecal microbiota with immune-mediated brain disease in dogs. | meningoencephalomyelitis of unknown origin (muo) is a common, naturally-occurring, clinical disease of pet dogs. it is an immune-mediated condition that has many similarities with experimental autoimmune encephalitis (eae) in rodents and so investigation of its pathogenesis may aid in understanding factors that contribute to development of multiple sclerosis in people. gut microbiota are known to modulate immune responses that influence susceptibility to immune-mediated brain disease. in this st ... | 2017 | 28125651 |
| microbial strain-level population structure and genetic diversity from metagenomes. | among the human health conditions linked to microbial communities, phenotypes are often associated with only a subset of strains within causal microbial groups. although it has been critical for decades in microbial physiology to characterize individual strains, this has been challenging when using culture-independent high-throughput metagenomics. we introduce strainphlan, a novel metagenomic strain identification approach, and apply it to characterize the genetic structure of thousands of strai ... | 2017 | 28167665 |
| faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice. | faecalibacterium prausnitzii is considered as one of the most important bacterial indicators of a healthy gut. we studied the effects of oral f. prausnitzii treatment on high-fat fed mice. compared to the high-fat control mice, f. prausnitzii-treated mice had lower hepatic fat content, aspartate aminotransferase and alanine aminotransferase, and increased fatty acid oxidation and adiponectin signaling in liver. hepatic lipidomic analyses revealed decreases in several species of triacylglycerols, ... | 2017 | 28375212 |
| nutritional, microbiological and psychosocial implications of the low fodmap diet. | dietary restriction of certain fermentable carbohydrates (low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (fodmap) diet) is effective for managing symptoms of irritable bowel syndrome (ibs). however, there are potential consequences of this diet that relate to its impact on nutritional, microbiological, and health-related quality of life outcomes. evidence suggests that the low fodmap diet leads to some alterations in nutrient intake. for example, carbohydrate intake ... | 2017 | 28244658 |
| microbial anti-inflammatory molecule (mam) from faecalibacterium prausnitzii shows a protective effect on dnbs and dss-induced colitis model in mice through inhibition of nf-κb pathway. | faecalibacterium prausnitzii and its supernatant showed protective effects in different chemically-induced colitis models in mice. recently, we described 7 peptides found in the f. prausnitzii supernatant, all belonging to a protein called microbial anti-inflammatory molecule (mam). these peptides were able to inhibit nf-κb pathway in vitro and showed anti-inflammatory properties in vivo in a dinitrobenzene sulfate (dnbs)-induced colitis model. in this current proof we tested mam effect on nf-κb ... | 2017 | 28203226 |
| probiotics and inflammatory bowel diseases. | intestinal microbiota is composed by symbiotic innocuous bacteria and potential pathogens also called pathobionts. even if the mechanism of action of intestinal bacteria remain still unknown, specific microbial species seem to have important role in the maintenance of immunological equilibrium in the gut through the direct interaction with immune cells. some studies have found a dysregulated interaction between the intestinal bacteria, the gut barrier, and the intestinal associated immune system ... | 2017 | 26634595 |
| ecology and metabolism of the beneficial intestinal commensal bacterium faecalibacterium prausnitzii. | faecalibacterium prausnitzii is a major commensal bacterium, and its prevalence is often decreased in conditions of intestinal dysbiosis. the phylogenic identity of this bacterium was described only recently. it is still poorly characterized, and its specific growth requirements in the human gastrointestinal tract are not known. in this review, we consider f. prausnitzii metabolism, its ecophysiology in both humans and animals, and the effects of drugs and nutrition on its population. we list im ... | 2017 | 24637606 |
| establishing a causal link between gut microbes, body weight gain and glucose metabolism in humans - towards treatment with probiotics. | changes in the gut microbiota are associated with metabolic disorders, such as overweight and elevated blood glucose. mouse studies have shown that gut microbiota can regulate metabolism with a mechanism related to gut barrier function. an impaired gut barrier permits the translocation of bacteria and their components which, when in contact with the sub-mucosal immune system, evoke metabolic inflammation and distract signalling in metabolically active tissues. despite thorough research of the to ... | 2016 | 26565087 |
| faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis. | atopic dermatitis (ad) is a serious global epidemic associated with a modern lifestyle. | 2016 | 26431583 |
| faecal proteomics: a tool to investigate dysbiosis and inflammation in patients with cystic fibrosis. | several microbial studies reported gut microbiota dysbiosis in patients with cystic fibrosis (cf). the functional consequences of this phenomenon are poorly understood. faecal metaproteomics allows the quantitative analysis of host and microbial proteins to address functional changes resulting from this dysbiosis. | 2016 | 26330184 |
| identification of an anti-inflammatory protein from faecalibacterium prausnitzii, a commensal bacterium deficient in crohn's disease. | crohn's disease (cd)-associated dysbiosis is characterised by a loss of faecalibacterium prausnitzii, whose culture supernatant exerts an anti-inflammatory effect both in vitro and in vivo. however, the chemical nature of the anti-inflammatory compounds has not yet been determined. | 2016 | 26045134 |
| siblings of patients with crohn's disease exhibit a biologically relevant dysbiosis in mucosal microbial metacommunities. | to determine the existence of mucosal dysbiosis in siblings of patients with crohn's disease (cd) using 454 pyrosequencing and to comprehensively characterise and determine the influence of genotypical and phenotypical factors, on that dysbiosis. siblings of patients with cd have elevated risk of developing cd and display aspects of disease phenotype, including faecal dysbiosis. whether the mucosal microbiota is disrupted in these at-risk individuals is unknown. | 2016 | 25856344 |
| faecalibacterium prausnitzii a2-165 has a high capacity to induce il-10 in human and murine dendritic cells and modulates t cell responses. | faecalibacterium prausnitzii strain a2-165 was previously reported to have anti-inflammatory properties and prevent colitis in a tnbs model. we compared the immunomodulatory properties of strain a2-165 to four different f. prausnitzii isolates and eight abundant intestinal commensals using human dendritic cells (dcs) and mouse bmdcs in vitro. principal component analysis revealed that the cytokine response to f. prausnitzii a2-165 is distinct from the other strains in eliciting high amounts of i ... | 2016 | 26725514 |
| signatures of early frailty in the gut microbiota. | frailty is arguably the biggest problem associated with population ageing, and associates with gut microbiome composition in elderly and care-dependent individuals. here we characterize frailty associations with the gut microbiota in a younger community dwelling population, to identify targets for intervention to encourage healthy ageing. | 2016 | 26822992 |
| bifidobacteria and butyrate-producing colon bacteria: importance and strategies for their stimulation in the human gut. | with the increasing amount of evidence linking certain disorders of the human body to a disturbed gut microbiota, there is a growing interest for compounds that positively influence its composition and activity through diet. besides the consumption of probiotics to stimulate favorable bacterial communities in the human gastrointestinal tract, prebiotics such as inulin-type fructans (itf) and arabinoxylan-oligosaccharides (axos) can be consumed to increase the number of bifidobacteria in the colo ... | 2016 | 27446020 |
| real friends: faecalibacterium prausnitzii supports mucosal immune homeostasis. | 2016 | 26531718 | |
| two healthy diets modulate gut microbial community improving insulin sensitivity in a human obese population. | gut microbiota, which acts collectively as a fully integrated organ in the host metabolism, can be shaped by long-term dietary interventions after a specific diet. | 2016 | 26505825 |
| ruthenibacterium lactatiformans gen. nov., sp. nov., an anaerobic, lactate-producing member of the family ruminococcaceae isolated from human faeces. | two novel strains of gram-stain-negative, rod-shaped, obligately anaerobic, non-spore-forming, non-motile bacteria were isolated from the faeces of healthy human subjects. the strains, designated as 585-1t and 668, were characterized by mesophilic fermentative metabolism, production of d-lactic acid, succinic acid and acetic acid as end products of d-glucose fermentation, prevalence of c18 : 1ω9, c18 : 1ω9 aldehyde, c16 : 0 and c16 : 1ω7c fatty acids, presence of glycine, glutamic acid, lysine, ... | 2016 | 27154556 |
| comparison of the gut microbial community between obese and lean peoples using 16s gene sequencing in a japanese population. | altered gut microbial ecology contributes to the development of metabolic diseases including obesity. in this study, we performed 16s rrna sequence analysis of the gut microbiota profiles of obese and lean japanese populations. the v3-v4 hypervariable regions of 16s rrna of fecal samples from 10 obese and 10 lean volunteers were sequenced using the illumina miseq(tm)ii system. the average body mass index of the obese and lean group were 38.1 and 16.6 kg/m(2), respectively (p<0.01). the shannon d ... | 2016 | 27499582 |
| relationship of enhanced butyrate production by colonic butyrate-producing bacteria to immunomodulatory effects in normal mice fed an insoluble fraction of brassica rapa l. | this study was performed to determine the effects of feeding a fiber-rich fraction of brassica vegetables on the immune response through changes in enteric bacteria and short-chain fatty acid (scfa) production in normal mice. the boiled-water-insoluble fraction of brassica rapa l. (nozawana), which consists mainly of dietary fiber, was chosen as a test material. a total of 31 male c57bl/6j mice were divided into two groups and housed in a specific-pathogen-free facility. the animals were fed eit ... | 2016 | 26921420 |
| gut microbiota richness and composition and dietary intake of overweight pregnant women are related to serum zonulin concentration, a marker for intestinal permeability. | increased intestinal permeability may precede adverse metabolic conditions. the extent to which the composition of the gut microbiota and diet contribute to intestinal permeability during pregnancy is unknown. | 2016 | 27466607 |
| the presence of the anti-inflammatory protein mam, from faecalibacterium prausnitzii, in the intestinal ecosystem. | 2016 | 26669616 | |
| faecal metaproteomic analysis reveals a personalized and stable functional microbiome and limited effects of a probiotic intervention in adults. | recent metagenomic studies have demonstrated that the overall functional potential of the intestinal microbiome is rather conserved between healthy individuals. here we assessed the biological processes undertaken in-vivo by microbes and the host in the intestinal tract by conducting a metaproteome analysis from a total of 48 faecal samples of 16 healthy adults participating in a placebo-controlled probiotic intervention trial. half of the subjects received placebo and the other half consumed la ... | 2016 | 27070903 |
| understanding the impact of omega-3 rich diet on the gut microbiota. | background. recently, the importance of the gut microbiota in the pathogenesis of several disorders has gained clinical interests. among exogenous factors affecting gut microbiome, diet appears to have the largest effect. fatty acids, especially omega-3 polyunsaturated, ameliorate a range of several diseases, including cardiometabolic and inflammatory and cancer. fatty acids associated beneficial effects may be mediated, to an important extent, through changes in gut microbiota composition. we s ... | 2016 | 27065349 |
| faecalibacterium prausnitzii phylotypes in type two diabetic, obese, and lean control subjects. | faecalibacterium prausnitzii is one of the main butyrate producers in the healthy human gut. information on its genetic diversity is lacking, although two genetic phylotypes have been differentiated. in the present study, f. prausnitzii phylotypes were examined in faeces of obese and type two diabetes with similar eating behaviour compared to a lean control group. the purpose of the study was to analyse if an excessive butyrate production induced by different f. prausnitzii phylotypes discrimina ... | 2016 | 27048834 |
| anti-tnf therapy response in patients with ulcerative colitis is associated with colonic antimicrobial peptide expression and microbiota composition. | anti-tumour necrosis factor [tnf] therapy is used in patients with ulcerative colitis [uc], but not all patients respond to treatment. antimicrobial peptides [amps] and the gut microbiota are essential for gut homeostasis and may be important for treatment outcome. the aim of this study was to determine amp and microbiota profiles in patients with uc before anti-tnf therapy start and correlate these data to treatment outcome. | 2016 | 26896085 |
| effects of cocoa husk feeding on the composition of swine intestinal microbiota. | a two-diet/two-period change over experiment was performed to investigate the effects of cocoa husks, as a source of dietary fiber and polyphenols, on pig intestinal microbial composition. six pigs were fed a conventional cereal-based diet or a diet obtained by substitution of 7.5% of the conventional diet with cocoa husks for 3 weeks. experimental diets were isoproteic and isoenergetic. at the end of each 3 week testing period, samples of fresh feces were collected and analyzed for microbial co ... | 2016 | 26877143 |
| the colonic microbiome and epithelial transcriptome are altered in rats fed a high-protein diet compared with a normal-protein diet. | a high-protein diet (hpd) can produce hazardous compounds and reduce butyrate-producing bacteria in feces, which may be detrimental to gut health. however, information on whether hpd affects intestinal function is limited. | 2016 | 26843585 |
| quantitative analysis of intestinal flora of uygur and han ethnic chinese patients with ulcerative colitis. | aim. to study the correlation between intestinal flora and ulcerative colitis by analyzing the abundance of bacteroides, fusobacterium, clostridium, bifidobacterium spp., and faecalibacterium prausnitzii in the intestinal of ulcerative colitis (uc) patients and healthy controls with uygur and han ethnic. methods. bacterial genomic dna was extracted from fecal samples and analyzed with real-time fluorescence quantitative polymerase chain reaction (pcr) to identify the abundance of bacteroides, fu ... | 2016 | 26839545 |
| anti-nociceptive effect of faecalibacterium prausnitzii in non-inflammatory ibs-like models. | visceral pain and intestinal dysbiosis are associated with irritable bowel syndrome (ibs), a common functional gastrointestinal disorder without available efficient therapies. in this study, a decrease of faecalibacterium prausnitzii presence has been observed in an ibs-like rodent model induced by a neonatal maternal separation (nms) stress. moreover, it was investigated whether f. prausnitzii may have an impact on colonic sensitivity. the a2-165 reference strain, but not its supernatant, signi ... | 2016 | 26775847 |
| modulation of the human gut microbiota by dietary fibres occurs at the species level. | dietary intake of specific non-digestible carbohydrates (including prebiotics) is increasingly seen as a highly effective approach for manipulating the composition and activities of the human gut microbiota to benefit health. nevertheless, surprisingly little is known about the global response of the microbial community to particular carbohydrates. recent in vivo dietary studies have demonstrated that the species composition of the human faecal microbiota is influenced by dietary intake. there i ... | 2016 | 26754945 |
| soluble arabinoxylan enhances large intestinal microbial health biomarkers in pigs fed a red meat-containing diet. | the aim of this study was to investigate how moderately increased dietary red meat combined with a soluble fiber (wheat arabinoxylan [ax]) alters the large intestinal microbiota in terms of fermentative end products and microbial community profiles in pigs. | 2016 | 26740253 |
| unique features of ethnic mongolian gut microbiome revealed by metagenomic analysis. | the human gut microbiota varies considerably among world populations due to a variety of factors including genetic background, diet, cultural habits and socioeconomic status. here we characterized 110 healthy mongolian adults gut microbiota by shotgun metagenomic sequencing and compared the intestinal microbiome among mongolians, the hans and european cohorts. the results showed that the taxonomic profile of intestinal microbiome among cohorts revealed the actinobaceria and bifidobacterium were ... | 2016 | 27708392 |
| the association between the gut microbiota and the inflammatory bowel disease activity: a systematic review and meta-analysis. | the pathogenesis of inflammatory bowel diseases (ibd) involves complex interactions between the microbiome and the immune system. we evaluated the association between the gut microbiota and disease activity in ibd patients. | 2016 | 27687331 |
| gut microbiota of obese, type 2 diabetic individuals is enriched in faecalibacterium prausnitzii, akkermansia muciniphila and peptostreptococcus anaerobius after weight loss. | beside the influence of nutritional habits and reduced physical activity, metabolic syndrome is associated with alterations in the structure of gut microbiota influencing the inflammatory immune responses. gut microbiota and microbial metabolic activities are known to affect the lipid and glucose metabolism, satiety and chronic low-grade inflammation in the metabolic syndrome. the aim of the study was to identify genera or even species affecting host metabolism in obesity and type 2 diabetes bes ... | 2016 | 27577947 |
| role of intestinal flora imbalance in pathogenesis of pouchitis. | to discuss the role of intestinal flora imbalance in the pathogenesis of pouchitis. | 2016 | 27569889 |
| gut microbiota associated with hiv infection is significantly enriched in bacteria tolerant to oxygen. | gut microbiota modifications occurring during hiv infection have recently been associated with inflammation and microbial translocation. however, discrepancies between studies justified a comprehensive analysis performed on a large sample size. | 2016 | 27547442 |
| gut microbial diversity is reduced in smokers with crohn's disease. | smoking has a negative impact on crohn's disease (cd), but the mechanisms underlying this association are unclear. we compared the gut microbiota composition of smoking with nonsmoking patients with cd using a metagenomic approach. | 2016 | 27542127 |
| a reduction in the butyrate producing species roseburia spp. and faecalibacterium prausnitzii is associated with chronic kidney disease progression. | the human gut microbiota plays an important role in human health and might also be implicated in kidney disease. the interest in butyrate producing bacteria has recently increased and is a poorly understood faecal condition in chronic kidney disease (ckd). therefore, we evaluated differences of the butyrate producing species roseburia spp. and faecalibacterium prausnitzii in the faeces of chinese patients with ckd. a case-control study was carried out for 65 ckd patients and 20 healthy controls. ... | 2016 | 27431681 |
| assessment of the prebiotic effect of quinoa and amaranth in the human intestinal ecosystem. | quinoa and amaranth belong to the group of the so called "superfoods" and have a nutritional composition that confers multiple benefits. in this work, we explored the possibility of these foods exhibiting a prebiotic effect. these pseudocereals were subjected to an in vitro digestion and used as carbon sources in batch cultures with faecal human inocula. the effects on the microbiota composition and their metabolic products were determined by assessment of variations in ph, short-chain fatty aci ... | 2016 | 27713989 |
| red wine polyphenols modulate fecal microbiota and reduce markers of the metabolic syndrome in obese patients. | this study evaluated the possible prebiotic effect of a moderate intake of red wine polyphenols on the modulation of the gut microbiota composition and the improvement in the risk factors for the metabolic syndrome in obese patients. ten metabolic syndrome patients and ten healthy subjects were included in a randomized, crossover, controlled intervention study. after a washout period, the subjects consumed red wine and de-alcoholized red wine over a 30 day period for each. the dominant bacterial ... | 2016 | 26599039 |
| age-associated effect of kestose on faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants. | although faecalibacterium prausnitzii is a major bacterium in the intestine of adults, which is known to have anti-inflammatory effects, the development in infants or the response to prebiotics remains unclear. | 2016 | 27537603 |
| faecalibacterium prausnitzii supernatant ameliorates dextran sulfate sodium induced colitis by regulating th17 cell differentiation. | to explore the preventive and therapeutic effects of faecalibacterium prausnitzii (f. prausnitzii) supernatant on dextran sulfate sodium (dss) induced colitis in mice. | 2016 | 27298563 |
| the microbiota in pediatric rheumatic disease: epiphenomenon or therapeutic target? | there has been increasing interest in the contents and function of the microbiota, as it relates to pediatric inflammatory diseases. here, we discuss the factors underlying the development of the microbiota, its role in juvenile idiopathic arthritis (jia) and prospects for therapeutic interventions in the microbiota. | 2016 | 27286235 |
| mucosa-associated ileal microbiota in new-onset pediatric crohn's disease. | the composition of the intestinal microbiome seems relevant to the pathogenesis of crohn's disease (cd), with differences in both diversity and composition of the gut microbiota in patients with cd compared with healthy individuals. however, there are still conflicting reports on the importance of various bacterial taxa in the pathogenesis of cd. the aim of this study was to characterize the composition of mucosa-associated intestinal microbiota in newly diagnosed pediatric patients with cd. | 2016 | 27271491 |
| emerging evidence of the role of gut microbiota in the development of allergic diseases. | the purpose is to review recent studies examining the role of gut microbiota in allergic diseases and asthma. | 2016 | 27253486 |
| similar depletion of protective faecalibacterium prausnitzii in psoriasis and inflammatory bowel disease, but not in hidradenitis suppurativa. | psoriasis and hidradenitis suppurativa [hs] co-occur more often with inflammatory bowel disease [ibd] than expected, due to shared pathogenic and genetic features. it is known that ibd patients harbour an altered intestinal microbiome characterised by a depletion of faecalibacterium prausnitzii and increase of escherichia coli. at present, it is unclear whether a similar intestinal microbiome trend can be identified in ibd-associated skin disorders. we therefore investigated the f. prausnitzii a ... | 2016 | 26971052 |
| changes in the abundance of faecalibacterium prausnitzii phylogroups i and ii in the intestinal mucosa of inflammatory bowel disease and patients with colorectal cancer. | faecalibacterium prausnitzii comprises 2 phylogroups, whose abundance in healthy and diseased gut and in conjunction with escherichia coli has not yet been studied. this work aims to determine the contribution of f. prausnitzii phylogroups i and ii in intestinal disease and to assess their potential diagnostic usefulness as biomarkers for gut diseases. | 2016 | 26595550 |
| comparative genomics of clostridium bolteae and clostridium clostridioforme reveals species-specific genomic properties and numerous putative antibiotic resistance determinants. | clostridium bolteae and clostridium clostridioforme, previously included in the complex c. clostridioforme in the group clostridium xiva, remain difficult to distinguish by phenotypic methods. these bacteria, prevailing in the human intestinal microbiota, are opportunistic pathogens with various drug susceptibility patterns. in order to better characterize the two species and to obtain information on their antibiotic resistance genes, we analyzed the genomes of six strains of c. bolteae and six ... | 2016 | 27769168 |
| structural robustness of the gut mucosal microbiota is associated with crohn's disease remission after surgery. | preventing postoperative recurrence after ileocolonic resection (icr) for crohn's disease (cd) is challenging. defining the disturbances of the microbial composition and community structure after icr and their link with early disease recurrence is crucial. | 2016 | 26628508 |
| fecal microbiota transplantation to fight clostridium difficile infections and other intestinal diseases. | we have analyzed fecal bacterial and viral communities of a patient with recurrent c. difficile infection (rcdi) who was cured by fecal microbiota transplantation (fmt). the "zürich patient" experienced immediate cure and has remained free of symptoms for now over 5 y. donor-similar bacterial compositions after 4.5 y post-fmt demonstrated sustainable engraftment of donor microbiota predominated by bacteroidetes and firmicutes bacteria. appearance of beneficial species faecalibacterium prausnitzi ... | 2016 | 28090385 |
| gut microbiota related to giardia duodenalis, entamoeba spp. and blastocystis hominis infections in humans from côte d'ivoire. | literature data provide little information about protozoa infections and gut microbiota compositional shifts in humans. this preliminary study aimed to describe the fecal bacterial community composition of people from côte d'ivoire harboring giardia duodenalis, entamoeba spp., and blastocystis hominis, in trying to discover possible alterations in their fecal microbiota structure related to the presence of such parasites. | 2016 | 27694739 |
| roux-en-y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota. | roux-en-y gastric bypass (rygb) is an effective means to achieve sustained weight loss for morbidly obese individuals. besides rapid weight reduction, patients achieve major improvements of insulin sensitivity and glucose homeostasis. dysbiosis of gut microbiota has been associated with obesity and some of its co-morbidities, like type 2 diabetes, and major changes of gut microbial communities have been hypothesized to mediate part of the beneficial metabolic effects observed after rygb. here we ... | 2016 | 27306058 |
| bifidobacterial inulin-type fructan degradation capacity determines cross-feeding interactions between bifidobacteria and faecalibacterium prausnitzii. | prebiotic inulin-type fructans (itf) display a bifidogenic and butyrogenic effect. four bifidobacterial strains (bifidobacterium breve yakult, bifidobacterium adolescentis lmg 10734, bifidobacterium angulatum lmg 11039(t), and bifidobacterium longum subsp. longum lmg 11047), displaying different itf degradation capacities, were each grown in cocultivation with faecalibacterium prausnitzii dsm 17677(t), an itf-degrading butyrate-producing colon bacterium, as to unravel their cross-feeding interac ... | 2016 | 27233082 |
| altered gut microbiota composition associated with eczema in infants. | eczema is frequently the first manifestation of an atopic diathesis and alteration in the diversity of gut microbiota has been reported in infants with eczema. to identify specific bacterial communities associated with eczema, we conducted a case-control study of 50 infants with eczema (cases) and 51 healthy infants (controls). we performed high-throughput sequencing for v3-v4 hypervariable regions of the 16s rrna genes from the gut fecal material. a total of 12,386 otus (operational taxonomic u ... | 2016 | 27812181 |
| sialoglycoprotein isolated from the eggs of carassius auratus prevents bone loss: an effect associated with the regulation of gut microbiota in ovariectomized rats. | the anti-osteoporotic effect of sialoglycoprotein isolated from the eggs of carassius auratus (ca-sgp) has previously been demonstrated in vivo. however, the mechanism by which this macromolecular substance regulates bone metabolism remains unclear. given the correlation between gut microbiota and the homeostasis of bone metabolism, the current study applied real-time pcr and 16s rrna high-throughput sequencing to investigate the influence of ca-sgp on gut microbiota in ovariectomized rats. real ... | 2016 | 27808338 |
| alterations in the mucosa-associated bacterial composition in crohn's disease: a pilot study. | changes in the intestinal bacterial composition seem to play a major role in the pathogenesis and in the clinical course of inflammatory bowel diseases (ibd), which consist of crohn's disease (cd), and ulcerative colitis (uc). mutations in the nod2 gene are the most important genetic risk factors for the development of cd. in this study, the association between mucosal biopsies and the mucosa-associated bacterial composition from cd and uc patients regarding their genetic risk factors (mutations ... | 2016 | 26951181 |
| intestinal microbiota and allergic diseases: a systematic review. | evidence suggests that possible imbalances in intestinal microbiota composition may be implicated in the occurrence of allergic diseases. although several studies published until 2006 indicated a correlation between microbiota composition and allergic symptoms, it has not been possible to distinguish protective microorganisms from those associated with increased risk of allergic diseases. therefore, the objective of this study was to review the studies published since 2007 that address the intes ... | 2016 | 25985709 |
| fecal microbiota in pouchitis and ulcerative colitis. | to investigate the changes in microbiota in feces of patients with ulcerative colitis (uc) and pouchitis using genomic technology. | 2016 | 27833384 |
| could gut microbiota serve as prognostic biomarker associated with colorectal cancer patients' survival? a pilot study on relevant mechanism. | evidences have shown that dysbiosis could promote the progression of colorectal cancer (crc). however, the association of dysbiosis and prognosis of crc is barely investigated. therefore, we used 16s rrna gene sequencing approach to determine differences in microbiota among tumor tissues of different prognosis and found that fusobacterium nucleatum and bacteroides fragilis were more abundant in worse prognosis groups, while faecalibacterium prausnitzii displayed higher abundance in survival grou ... | 2016 | 27323816 |
| effect of oligosaccharides on the adhesion of gut bacteria to human ht-29 cells. | the influence of five oligosaccharides (cellobiose, stachyose, raffinose, lactulose and chito-oligosaccharides) on the adhesion of eight gut bacteria (bifidobacterium bifidum atcc 29521, bacteroides thetaiotaomicron atcc 29148d-5, clostridium leptum atcc 29065, blautia coccoides atcc 29236, faecalibacterium prausnitzii atcc 27766, bacteroides fragilis atcc 23745, clostridium difficile atcc 43255 and lactobacillus casei atcc 393) to mucous secreting and non-mucous secreting ht-29 human epithelial ... | 2016 | 27018325 |
| the gut microbial community in metabolic syndrome patients is modified by diet. | intestinal microbiota changes may be involved in the development of metabolic syndrome (mets), which is a multicomponent disorder frequently associated with obesity. the aim of this study was to test the effect of consuming two healthy diets: a mediterranean diet and a low-fat high-carbohydrate diet, for 2years in the gut microbiota of mets patients and those in the control group. we analyzed the differences in the bacterial community structure between the groups after 2years of dietary interven ... | 2016 | 26376027 |
| [bacterial chemotypes in epidemiology]. | 2016 | 4928084 | |
| [lenin's theory of reflection and modern medicine (gnoseologic aspects of the problem)]. | 2016 | 4928258 | |
| [the use of connectors in removable prostheses]. | 2016 | 4918027 | |
| the 1970 annual meeting of the american rheumatism association. | 2016 | 4926452 | |
| [professor maria briese]. | 2016 | 4905678 | |
| intestinal microbiota and microbial metabolites are changed in a pig model fed a high-fat/low-fiber or a low-fat/high-fiber diet. | the intestinal microbiota and its metabolites appear to be an important factor for gastrointestinal function and health. however, research is still needed to further elaborate potential relationships between nutrition, gut microbiota and host's health by means of a suitable animal model. the present study examined the effect of two different diets on microbial composition and activity by using the pig as a model for humans. eight pigs were equally allotted to two treatments, either fed a low-fat ... | 2016 | 27100182 |
| intestinal microbiota distinguish gout patients from healthy humans. | current blood-based approach for gout diagnosis can be of low sensitivity and hysteretic. here via a 68-member cohort of 33 healthy and 35 diseased individuals, we reported that the intestinal microbiota of gout patients are highly distinct from healthy individuals in both organismal and functional structures. in gout, bacteroides caccae and bacteroides xylanisolvens are enriched yet faecalibacterium prausnitzii and bifidobacterium pseudocatenulatum depleted. the established reference microbial ... | 2016 | 26852926 |
| correlation between diet and gut bacteria in a population of young adults. | dietary habits strongly influence gut microbiota. the aim of this study was to compare and correlated the abundance of firmicutes and bacteroidetes phyla, some representative bacteria of these phyla such as bacteroides thetaiotaomicron, prevotella, faecalibacterium prausnitzii, clostridium leptum and bifidobacterium longum as a member of actinobacteria phylum in young adults with their food intake. faecal samples used came from lean subjects (bmi = 19.83 ± 0.94 kg/m(2)), overweight (bmi = 27.17 ... | 2016 | 27018166 |
| the microbiota shifts the iron sensing of intestinal cells. | the amount of iron in the diet directly influences the composition of the microbiota. inversely, the effects of the microbiota on iron homeostasis have been little studied. so, we investigate whether the microbiota itself may alter host iron sensing. duodenal cytochrome b and divalent metal transporter 1, involved in apical iron uptake, are 8- and 10-fold, respectively, more abundant in the duodenum of germ-free (gf) mice than in mice colonized with a microbiota. in contrast, the luminal exporte ... | 2016 | 26370847 |
| the immediate effect of physiotherapy and water aerosol ippb treatment on the peak expiratory flow rate in asthmatic patients. | 2016 | 4893749 | |
| the effect of octapressin on renal and intrarenal blood flow in cirrhosis of the liver. | the effect of octapressin (2-phenylalanine-8-lysine vasopressin) on renal and intrarenal blood flow was studied in 11 normotensive cirrhotic patients with abnormal renal perfusion. renal haemodynamic changes were assessed with the (133)xenon washout technique. of the six patients given suppressor doses of octapressin intravenously renal blood flow improved in one only. a further three patients responded to the drug in a dose which increased the mean arterial pressure by 5 or more mm hg. the incr ... | 2016 | 5033844 |
| preliminary survey of medical care in hawaii. 1. hospital care. | 2016 | 4876386 | |
| [long-term results of mitral comissurotomy (apropos of 32 cases)]. | 2016 | 5036217 | |
| [achievements in microbiology and virology in the ukrainian ssr after the great october socialist revolution]. | 2016 | 4920845 |