Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| the global regulators lrp, leuo, and hexa control secondary metabolism in entomopathogenic bacteria. | photorhabdus luminescens tto1 and xenorhabdus nematophila hgb081 are insect pathogenic bacteria and producers of various structurally diverse bioactive natural products. in these entomopathogenic bacteria we investigated the role of the global regulators lrp, leuo, and hexa in the production of natural products. lrp is a general activator of natural product biosynthesis in x. nematophila and for most compounds in tto1. microarray analysis confirmed these results in x. nematophila and enabled the ... | 2017 | 28261170 |
| larvicidal and growth-inhibitory activity of entomopathogenic bacteria culture fluids against aedes aegypti (diptera: culicidae). | dengue, chikungunya, and zika are important vector-borne diseases, and aedes aegypti l. is their main transmitter. as the disease management is mainly based on mosquito control strategies, the search for alternative and cost-effective approaches is ongoing. the gram-negative bacteria xenorhabdus nematophila and photorhabdus luminescens are symbiotically associated with entomopathogenic nematodes and are highly pathogenic for insect larvae. after we have recently confirmed the toxicity of these b ... | 2017 | 28062794 |
| biosynthesis of the antibiotic nematophin and its elongated derivatives in entomopathogenic bacteria. | nematophin, a known antibiotic natural product against staphylococcus aureus for almost 20 years, is produced by all strains of xenorhabdus nematophila. despite its simple structure, its biosynthesis was unknown. its biosynthetic pathway is reported using heterologous production in escherichia coli. additionally, the identification, structure elucidation, and biosynthesis of six extended nematophin derivatives from xenorhabdus pb62.4 carrying an additional valine are reported. preliminary bioact ... | 2017 | 28134534 |
| r-type bacteriocins in related strains of xenorhabdus bovienii: xenorhabdicin tail fiber modularity and contribution to competitiveness. | r-type bacteriocins are contractile phage tail-like structures that are bactericidal towards related bacterial species. the c-terminal region of the phage tail fiber protein determines target-binding specificity. the mutualistic bacteria xenorhabdus nematophila and x. bovienii produce r-type bacteriocins (xenorhabdicins) that are selectively active against different xenorhabdus species. we analyzed the p2-type remnant prophage clusters in draft sequences of nine strains of x. bovienii the c-term ... | 2017 | 27737947 |
| high levels of the xenorhabdus nematophila transcription factor lrp promote mutualism with steinernema carpocapsae nematode hosts. | xenorhabdus nematophila bacteria are mutualistic symbionts of steinernema carpocapsae nematodes and pathogens of insects. the x. nematophila global regulator lrp controls expression of many genes involved in both mutualism and pathogenic activities, suggesting a role in the transition between the two host organisms. we previously reported that natural populations of x. nematophila exhibit variable levels of lrp expression, and that cells expressing relatively low levels of lrp are optimized for ... | 2017 | 28389546 |
| the genome, transcriptome, and proteome of the nematode steinernema carpocapsae: evolutionary signatures of a pathogenic lifestyle. | the entomopathogenic nematode steinernema carpocapsae has been widely used for the biological control of insect pests. it shares a symbiotic relationship with the bacterium xenorhabdus nematophila, and is emerging as a genetic model to study symbiosis and pathogenesis. we obtained a high-quality draft of the nematode's genome comprising 84,613,633 bp in 347 scaffolds, with an n50 of 1.24 mb. to improve annotation, we sequenced both short and long rna and conducted shotgun proteomic analyses. s. ... | 2016 | 27876851 |
| nematode-bacteria mutualism: selection within the mutualism supersedes selection outside of the mutualism. | the coevolution of interacting species can lead to codependent mutualists. little is known about the effect of selection on partners within verses apart from the association. here, we determined the effect of selection on bacteria (xenorhabdus nematophila) both within and apart from its mutualistic partner (a nematode, steinernema carpocapsae). in nature, the two species cooperatively infect and kill arthropods. we passaged the bacteria either together with (m+), or isolated from (m-), nematodes ... | 2016 | 26867502 |
| effects of an entomopathogen nematode on the immune response of the insect pest red palm weevil: focus on the host antimicrobial response. | relationships between parasites and hosts can be drastic, depending on the balance between parasite strategies and the efficiency of the host immune response. in the case of entomopathogenic nematodes and their insect hosts, we must also consider the role of bacterial symbionts, as the interaction among them is tripartite and each component plays a critical role in death or survival. we analyzed the effects induced by the nematode-bacteria complex steinernema carpocapsae, against red palm weevil ... | 2016 | 26549224 |
| pseudomonas brassicacearum strain df41 kills caenorhabditis elegans through biofilm-dependent and biofilm-independent mechanisms. | pseudomonas brassicacearum df41 is a biocontrol agent that suppresses disease caused by the fungal pathogen sclerotinia sclerotiorum a number of exometabolites are produced by df41 including the lipopeptide sclerosin, hydrogen cyanide (hcn) and degradative enzymes. production of these compounds is controlled at both the transcriptional and posttranscriptional level by quorum sensing (qs) and the gac-two component regulatory system. in order to be successful, a biocontrol agent must persist in th ... | 2016 | 27637885 |
| activating and attenuating the amicoumacin antibiotics. | the amicoumacins belong to a class of dihydroisocoumarin natural products and display antibacterial, antifungal, anticancer, and anti-inflammatory activities. amicoumacins are the pro-drug activation products of a bacterial nonribosomal peptide-polyketide hybrid biosynthetic pathway and have been isolated from gram-positive bacillus and nocardia species. here, we report the stimulation of a "cryptic" amicoumacin pathway in the entomopathogenic gram-negative bacterium xenorhabdus bovienii, a stra ... | 2016 | 27347911 |
| a mixture of bacillus thuringiensis subsp. israelensis with xenorhabdus nematophila-cultured broth enhances toxicity against mosquitoes aedes albopictus and culex pipiens pallens (diptera: culicidae). | xenorhabdusandphotorhabdusspp. (enterobacteriaceae) can synthesize and release secondary metabolites that play crucial roles in their pathogenicity by suppressing the immunity of target insects. the insect immunity contributes to defense against the pathogenicity ofbacillus thuringiensis(bt). this study tested a hypothesis that bacterial immunosuppresants could enhance the susceptibility of mosquitoes (aedes albopictusandculex pipiens pallens) to bt. three symbiotic bacteria [x. nematophila(xn), ... | 2016 | 27018440 |
| flagellar regulation and virulence in the entomopathogenic bacteria-xenorhabdus nematophila and photorhabdus luminescens. | there is a complex interplay between the regulation of flagellar motility and the expression of virulence factors in many bacterial pathogens. here, we review the literature on the direct and indirect roles of flagellar motility in mediating the tripartite interaction between entomopathogenic bacteria (photorhabdus and xenorhabdus), their nematode hosts, and their insect targets. first, we describe the swimming and swarming motility of insect pathogenic bacteria and its impact on insect coloniza ... | 2016 | 28091933 |
| preparation of agar wells for antibiotic assay. | 2016 | 4971723 | |
| comparative analysis of xenorhabdus koppenhoeferi gene expression during symbiotic persistence in the host nematode. | species of xenorhabdus and photorhabdus bacteria form mutualistic associations with steinernema and heterorhabditis nematodes, respectively and serve as model systems for studying microbe-animal symbioses. here, we profiled gene expression of xenorhabdus koppenhoeferi during their symbiotic persistence in the newly formed infective juveniles of the host nematode steinernema scarabaei through the selective capture of transcribed sequences (scots). the obtained gene expression profile was then com ... | 2016 | 26745883 |
| candidate pathogenicity islands in the genome of 'candidatus rickettsiella isopodorum', an intracellular bacterium infecting terrestrial isopod crustaceans. | the bacterial genus rickettsiellabelongs to the order legionellales in the gammaproteobacteria, and consists of several described species and pathotypes, most of which are considered to be intracellular pathogens infecting arthropods. two members of this genus, r. grylliand r. isopodorum, are known to infect terrestrial isopod crustaceans. in this study, we assembled a draft genomic sequence for r. isopodorum, and performed a comparative genomic analysis with r. grylli. we found evidence for sev ... | 2016 | 28028472 |
| [preventive vaccinations in allergic patients. 2]. | 2016 | 4755656 | |
| the nucleolar organizer of plethodon cinereus cinereus (green). i. location of the nucleolar organizer by in situ nucleic acid hybridization. | 2016 | 4730559 | |
| xanthine overdose. | 2016 | 5029168 | |
| [determining the borderline between stage i-a and stage i-b of carcinoma of the uterine cervix]. | 2016 | 4742615 | |
| [effects of repeated interventions in ear surgery]. | 2016 | 5020044 | |
| [clinical evaluation of gentamicin garamycin in the treatment of postpartum and post-abortion infectious complications]. | 2016 | 4779222 | |
| pseudomyopia as a presenting sign in ocular myasthenia gravis. | 2016 | 4706420 | |
| the use of his-bundle electrocardiography in conduction disturbances of the heart. | 2016 | 4758244 | |
| [functional disorders of the biliary tracts]. | 2015 | 4553777 | |
| direct coronary revascularization. | 2015 | 4542165 | |
| [papilledema in spinal neoplasms]. | 2015 | 4638163 | |
| a new dental superalloy system. 3. microstructure and phase transformations. | 2015 | 4509488 | |
| on the possible origin and evolution of the genetic code. | 2015 | 4414917 | |
| investigation on the epidemiological significance of detailed cancer data--preliminary results. | 2015 | 4352667 | |
| pletysmographic and intramedullary pressure measurements before and after tibial osteotomy for osteoarthritis of the knee. | 2015 | 4432738 | |
| [ilioinguinal syndrome]. | 2015 | 4332489 | |
| the global transcription factor lrp controls virulence modulation in xenorhabdus nematophila. | the bacterium xenorhabdus nematophila engages in phenotypic variation with respect to pathogenicity against insect larvae, yielding both virulent and attenuated subpopulations of cells from an isogenic culture. the global regulatory protein lrp is necessary for x. nematophila virulence and immunosuppression in insects, as well as colonization of the mutualistic host nematode steinernema carpocapsae, and mediates expression of numerous genes implicated in each of these phenotypes. given the centr ... | 2015 | 26170407 |
| [history of cataract treatment]. | 2015 | 4575472 | |
| [60th birthday of prof. václav trnka, dr. sc]. | 2015 | 4551569 | |
| current reference works in public health. | 2015 | 4557014 | |
| nursing care study: secondary dementia. | 2015 | 4486325 | |
| a myoglobin-type haemoglobin of chironomus thummi thummi. | 2015 | 4333654 | |
| a novel pilin subunit from xenorhabdus nematophila, an insect pathogen, confers pest resistance in tobacco and tomato. | overexpression of insecticidal pilin subunit from xenorhabdus nematophila protects transgenic tobacco and tomato plants against helicoverpa armigera. xenorhabdus nematophila is a pathogenic bacterium producing toxins that kill the larval host. previously, we characterized a pilin subunit of x. nematophila which was found to be a pore-forming toxin and cytotoxic to the larval hemocytes of helicoverpa armigera by causing agglutination and lysis of the cells. in the present study, we report the eff ... | 2015 | 26164296 |
| ectopic expression of groel from xenorhabdus nematophila in tomato enhances resistance against helicoverpa armigera and salt and thermal stress. | the groel homolog xngroel protein of xenorhabdus nematophila belongs to a highly conserved family of molecular chaperones/heat shock proteins (hsps). xngroel was shown to possess oral insecticidal activity against a major crop pest helicoverpa armigera. under normal conditions, the hsps/chaperones facilitate folding, assembly, and translocation of cellular proteins, while in stress conditions they protect proteins from denaturation. in this study, we describe generation of transgenic tomato plan ... | 2015 | 25958082 |
| draft genome sequence and annotation of the insect pathogenic bacterium xenorhabdus nematophila strain c2-3, isolated from nematode steinernema carpocapsae in the republic of korea. | xenorhabdus nematophila strain c2-3, which belongs to the family enterobacteriaceae, was isolated from entomopathogenic nematodes collected in the republic of korea. herein, we report a 4.38-mbp draft genome sequence of x. nematophila strain c2-3, with a 43.6% g+c content. the rast annotation analysis revealed 4,994 protein-coding sequences in the draft genome. | 2015 | 25676754 |
| variation in the susceptibility of drosophila to different entomopathogenic nematodes. | entomopathogenic nematodes (epns) in the genera heterorhabditis and steinernema are lethal parasites of insects that are of interest as models for understanding parasite-host interactions and as biocontrol agents for insect pests. epns harbor a bacterial endosymbiont in their gut that assists in insect killing. epns are capable of infecting and killing a wide range of insects, yet how the nematodes and their bacterial endosymbionts interact with the insect immune system is poorly understood. her ... | 2015 | 25561714 |
| role of secondary metabolites in establishment of the mutualistic partnership between xenorhabdus nematophila and the entomopathogenic nematode steinernema carpocapsae. | xenorhabdus nematophila engages in a mutualistic partnership with the nematode steinernema carpocapsae, which invades insects, migrates through the gut, and penetrates into the hemocoel (body cavity). we showed previously that during invasion of manduca sexta, the gut microbe staphylococcus saprophyticus appeared transiently in the hemocoel, while enterococcus faecalis proliferated as x. nematophila became dominant. x. nematophila produces diverse secondary metabolites, including the major water ... | 2015 | 25398871 |
| examining reaction specificity in pvcb, a source of diversity in isonitrile-containing natural products. | many bacteria produce isonitrile-containing natural products that are derived from aromatic amino acids. the synthetic clusters that control biosynthesis most commonly encode two enzymes, designated pvca and pvcb, as well as additional enzymes that direct synthesis of the natural product. the pvca enzyme installs the isonitrile moiety at the amino group of either tyrosine or tryptophan, as dictated by the particular pathway. the common pathway intermediate produced by pvca is directed toward dif ... | 2015 | 25866990 |
| an improved method for generating axenic entomopathogenic nematodes. | steinernema carpocapsae are parasitic nematodes that invade and kill insects. the nematodes are mutualistically associated with the bacteria xenorhabdus nematophila and together form an excellent model to study pathogen infection processes and host anti-nematode/antibacterial immune responses. to determine the contribution of s. carpocapsae and their associated x. nematophila to the successful infection of insects as well as to investigate the interaction of each mutualistic partner with the ins ... | 2015 | 26386557 |
| the expectations and realities of kidney transplant patients. | 2015 | 4615251 | |
| [skeletal traction in the treatment of pelvic bone fractures]. | 2015 | 4421797 | |
| a universal device for positive end-expiratory pressure (peep). | 2015 | 4585936 | |
| [the process of maturation of the proximal epiphyses of both bones of the forearm in the female]. | 2014 | 4288884 | |
| [the process of maturation of the proximal epiphyses of both bones of the forearm in the female]. | 2014 | 4288884 | |
| improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. | 2014 | 4116150 | |
| xenortide biosynthesis by entomopathogenic xenorhabdus nematophila. | the biosynthesis gene cluster of the xenortides and a new derivative, xenortide d, which is produced in only trace amounts, was identified in xenorhabdus nematophila. the structure of xenortide d was elucidated using a combination of labeling experiments followed by ms analysis and was confirmed by synthesis. bioactivity tests revealed a weak activity of tryptamine-carrying xenortides against plasmodium falciparum and trypanosoma brucei. | 2014 | 25080196 |
| a novel insecticidal groel protein from xenorhabdus nematophila confers insect resistance in tobacco. | xenorhabdus nematophila is an entomopathogenic bacteria. it secretes a groel homolog, xngroel protein, toxic to its larval prey. groel belongs to the family of molecular chaperones and is required for proper folding of cellular proteins. oral ingestion of insecticidal xngroel protein is toxic to helicoverpa armigera, leading to cessation of growth and development of the larvae. in the present study, the insecticidal efficacy of xngroel against h. armigera has been evaluated in transgenic tobacco ... | 2014 | 23888329 |
| a functional genomic screen for evolutionarily conserved genes required for lifespan and immunity in germline-deficient c. elegans. | the reproductive system regulates lifespan in insects, nematodes and vertebrates. in caenorhabditis elegans removal of germline increases lifespan by 60% which is dependent upon insulin signaling, nuclear hormone signaling, autophagy and fat metabolism and their microrna-regulators. germline-deficient c. elegans are also more resistant to various bacterial pathogens but the underlying molecular mechanisms are largely unknown. firstly, we demonstrate that previously identified genes that regulate ... | 2014 | 25093668 |
| physiological constants of the entomopathogenic bacterium xenorhabdus nematophila determined by microbial growth kinetics. | xenorhabdus nematophila, an entomopathogenic bacterium that symbiotically associates with the entomoparasitic nematode steinernema carpocapsae, was studied to determine its physiological parameters of glucose utilization. x. nematophila was cultured in chemically defined media containing various concentrations of glucose under optimal conditions utilizing a two-liter fermentation system. specific growth rates were obtained from each glucose batch. specific growth rates and their associated gluco ... | 2014 | 24944838 |
| sequential immunosuppressive activities of bacterial secondary metabolites from the entomopahogenic bacterium xenorhabdus nematophila. | the entomopathogenic bacterium xenorhabdus nematophila secretes at least eight bacterial metabolites that play crucial roles suppressing target insect immune responses by inhibiting eicosanoid biosynthesis. we analyzed sequential changes in bacterial metabolite production during bacterial growth and analyzed their individual immunosuppressive activities against the insect host, spodoptera exigua. x. nematophila exhibited a typical bacterial growth pattern in both insect host and culture medium, ... | 2014 | 24500481 |
| development of a high efficient "dual bt-plus" insecticide using a primary form of an entomopathogenic bacterium, xenorhabdus nematophila. | a phase variation has been reported in an entomopathogenic bacterium, xenorhabdus nematophila. compared with a wild-type primary form, a secondary form usually loses several physiological and biochemical characters. this study showed that the phase variation of x. nematophila caused a significant alteration in its immunosuppressive activity and subsequent entomopathogenicity. a secondary form of x. nematophila was detected in laboratory colonies and exhibited significant differences in dye absor ... | 2014 | 24394195 |
| expression, purification, and functional analysis of novel rele operon from x. nematophila. | bacterial toxin-antitoxin (ta) complexes induce programmed cell death and also function to relieve cell from stress by various response mechanisms. escherichia coli relb-rele ta complex consists of a rele toxin functionally counteracted by relb antitoxin. in the present study, a novel homolog of rele toxin designated as xn-rele toxin from xenorhabdus nematophila possessing its own antitoxin designated as xn-releat has been identified. expression and purification of recombinant proteins under nat ... | 2014 | 25538952 |
| rapid determination of the amino acid configuration of xenotetrapeptide. | an e. coli strain with deletions in five transaminases (δaspc δilve δtyrb δavta δybfq) was constructed to be unable to degrade several amino acids. this strain was used as an expression host for the analysis of the amino acid configuration of nonribosomally synthesized peptides, including the novel peptide "xenotetrapeptide" from xenorhabdus nematophila, by using a combination of labeling experiments and mass spectrometry. additionally, the number of d-amino acids in the produced peptide was ass ... | 2014 | 24616055 |
| inhibitory effect of xenorhabdus nematophila tb on plant pathogens phytophthora capsici and botrytis cinerea in vitro and in planta. | entomopathogenic bacteria xenorhabdus spp. produce secondary metabolites with potential antimicrobial activity for use in agricultural productions. this study evaluated the inhibitory effect of x. nematophila tb culture on plant pathogens botrytis cinerea and phytophthora capsici. the cell-free filtrate of tb culture showed strong inhibitory effects (>90%) on mycelial growth of both pathogens. the methanol-extracted bioactive compounds (methanol extract) of tb culture also had strong inhibitory ... | 2014 | 24599183 |
| chemotherapy of cancer of the colon and rectum. | 2014 | 4260654 | |
| [bilateral wrist fractures]. | 2014 | 4017731 | |
| phytosterolemia and hypercholesterolemia in childhood. | 2014 | 3944712 | |
| nild crispr rna contributes to xenorhabdus nematophila colonization of symbiotic host nematodes. | the bacterium xenorhabdus nematophila is a mutualist of entomopathogenic steinernema carpocapsae nematodes and facilitates infection of insect hosts. x. nematophila colonizes the intestine of s. carpocapsae which carries it between insects. in the x. nematophila colonization-defective mutant nild6::tn5, the transposon is inserted in a region lacking obvious coding potential. we demonstrate that the transposon disrupts expression of a single crispr rna, nild rna. a variant nild rna also is expres ... | 2014 | 25041533 |
| microbial population dynamics in the hemolymph of manduca sexta infected with xenorhabdus nematophila and the entomopathogenic nematode steinernema carpocapsae. | xenorhabdus nematophila engages in a mutualistic association with the nematode steinernema carpocapsae. the nematode invades and traverses the gut of susceptible insects. x. nematophila is released in the insect blood (hemolymph), where it suppresses host immune responses and functions as a pathogen. x. nematophila produces diverse antimicrobials in laboratory cultures. the natural competitors that x. nematophila encounters in the hemolymph and the role of antimicrobials in interspecies competit ... | 2014 | 24814780 |
| [endoscopy supported biochemical pancreatic differential diagnosis within the scope of a diagnosis strategy]. | 2014 | 3993163 | |
| studies on the apparent instability of neurospora tryptophan synthase. evidence for protease. | 2014 | 4265723 | |
| muscle membrane protein kinase in myotonic muscular dystrophy. | 2014 | 4277586 | |
| muscle membrane protein kinase in myotonic muscular dystrophy. | 2014 | 4277586 | |
| fluorouracil and radiotherapy in gastrointesinal cancer. | 2014 | 4187834 | |
| [cytodiagnosis of tumors of the gastrointestinal system]. | 2014 | 4135741 | |
| [arthrocele in rheumatic knee joint diseases]. | 2014 | 4234257 | |
| posttraumatic acalculous cholecystitis. | 2014 | 4068695 | |
| electrophysiological studies of myoclonic jerks provoked by photic stimulation. | a patient with a type of myoclonus produced by somatosensory and photic stimuli was studied electrophysiologically. jerk-locked averaging showed cortical spikes in association with the spontaneous myoclonus. high amplitude somatosensory evoked potentials and high amplitude visual evoked potentials were observed. somatosensory and photic stimuli produced 2 or 3 successive electromyographic (emg) discharges. the time interval from the onset of the preceding emg discharge to that of the following e ... | 2014 | 4013664 |
| free and conjugated estrogens of an ovarian cystadenoma and granulosa cell tumor. | 2014 | 4284085 | |
| [detection and identification of bezo-(f)-diazepine-1,4 derivatives in urine]. | 2014 | 4156460 | |
| [treatment of eyelid epitheliomas by betatron]. | 2014 | 4219756 | |
| tentative immunochemical analysis of the prothrombin molecule. | 2014 | 4122342 | |
| physiological stress and performance changes in response to beginning level orienteering. | 2014 | 4068683 | |
| transdermally administered scopolamine. | 2014 | 4063911 | |
| dna damage measured using the alkaline elution assay depends on time between subculturing of cells and irradiation. | in experiments utilizing the alkaline filter elution assay for radiation-induced dna damage we observed an unexpected dependence of hypoxic dose-response curves on the length of time v79 cells were in exponential growth between subculturing and irradiation. dose-response curves for dna from cells irradiated in air were identical regardless of whether the exponential-phase cells had been subcultured 24 or 48 h prior to irradiation, but cells irradiated in hypoxia 24 h after subculture displayed a ... | 2014 | 3952272 |
| laryngeal trauma vs length of intubation. | the frequency histograms of six patients' laryngographs were studied pre- and post-endotracheal intubation. the changes were correlated with the length of intubation. the post-operative hoarse voice was seen as an increase in the spread of the lower frequencies, and an increase in the fundamental frequency. the latter change was thought to be a subconscious compensation for the hoarseness. the increased lower frequency spread as measured by standard deviation was directly proportional to the len ... | 2013 | 3694032 |
| serum formate concentrations in methanol intoxication as a criterion for hemodialysis. | to evaluate the utility of serum formate concentrations, four patients were studied after ingestion of a methanolic copying fluid. all patients were initially intoxicated. twelve to twenty-four hours later, signs and symptoms included nausea, abdominal pain, hypokalemia, acidosis (three patients), and pathologic ocular findings (two patients). all patients were treated with ethanol and folate. the two patients with ocular signs and acidosis had high serum formate concentrations (75 and 55 mg/dl, ... | 2013 | 3946945 |
| serum formate concentrations in methanol intoxication as a criterion for hemodialysis. | to evaluate the utility of serum formate concentrations, four patients were studied after ingestion of a methanolic copying fluid. all patients were initially intoxicated. twelve to twenty-four hours later, signs and symptoms included nausea, abdominal pain, hypokalemia, acidosis (three patients), and pathologic ocular findings (two patients). all patients were treated with ethanol and folate. the two patients with ocular signs and acidosis had high serum formate concentrations (75 and 55 mg/dl, ... | 2013 | 3946945 |
| multiple pulmonary artery aneurysms. new use for magnetic resonance imaging. | the first patient in whom multiple pulmonary artery aneurysms were detected by magnetic resonance imaging is described. the patient was successfully treated with surgery. | 2013 | 3799628 |
| the cutting diathermy and drain tracts. | 2013 | 3810377 | |
| developmental abnormalities in the chemically dependent newborn. | 2013 | 3647988 | |
| falls in the elderly. | 2013 | 3737546 | |
| slow-release nifedipine associated with muzolimine in the treatment of mild to moderate essential hypertension. | 2013 | 3826145 | |
| stability of propranolol hydrochloride suspension compounded from tablets. | the stability of a propranolol hydrochloride suspension compounded from commercially available tablets was studied. propranolol hydrochloride 10-mg tablets were triturated to a powder and incorporated into a commercially available suspension vehicle to yield a suspension with a theoretical propranolol hydrochloride concentration of 1 mg/ml. the suspension was divided into portions and stored in amber glass bottles at either room (25 degrees c) or refrigerated (2 degrees c) temperature for four m ... | 2013 | 3728486 |
| fibrin degradation products (fdp) and inhibitors in retroplacental blood. | 2013 | 3749937 | |
| effects of pseudostuttering on normal speakers' self-ratings of beauty. | forty-three undergraduate and 12 graduate students provided numerical evaluations of their own outer beauty and inner beauty, both in class, and immediately following a pseudostuttering assignment. both groups had significant downshifts in both parameters of beauty. the undergraduate students had greater downshifts in both areas than did the graduate students. it was concluded that, pseudostuttering assignments represent a viable instrument for allowing student clinicians to experience negative ... | 2013 | 3624530 |
| [effect of levamisole on nonspecific resistance of patients in the early post-shock period]. | the authors consider that the application of levamisol in the treatment of patients decreases the amount of complications if the degree of shock was not great. in greater degree of shock levamisole failed to exert a favorable effect. | 2013 | 3750693 |
| [infantile uncinariasis as a public health problem]. | 2013 | 3814329 | |
| [effect of long-term ambulatory hypotensive treatment on the structural and functional status of the myocardium]. | changes in myocardial function and the possibility of a regression of left-ventricular hypertrophy were examined in patients with stable hypertension during a year of effective hypotensive treatment. ninety-seven patients with essential hypertension, stage iib (by myasnikov's classification) and aged 35 to 56 years, were studied. echography was conducted before the onset of treatment and after one year of regular hypotensive therapy. a marked hypotensive effect was noted in the course of treatme ... | 2013 | 3712955 |
| yaxab, a yersinia enterocolitica pore-forming toxin regulated by rova. | the transcriptional regulator rova positively regulates transcription of the yersinia enterocolitica virulence gene inv. invasin, encoded by inv, is important for establishment of y. enterocolitica infection. however, a rova mutant is more attenuated for virulence than an inv mutant, implying that rova regulates additional virulence genes. when the y. enterocolitica rova regulon was defined by microarray analysis, ye1984 and ye1985 were among the genes identified as being upregulated by rova. si ... | 2013 | 24002058 |
| xenocin export by the flagellar type iii pathway in xenorhabdus nematophila. | the xenocin operon of xenorhabdus nematophila consists of xcia and ximb genes encoding a 64-kda xenocin and 42-kda immunity protein to kill competing microbes in the insect larva. the catalytic domain of xenocin has rnase activity and is responsible for its cytotoxicity. under sos conditions, xenocin is produced with immunity protein as a complex. here, we show that xenocin and immunity protein complex are exported through the flagellar type iii system of x. nematophila. secretion of xenocin com ... | 2013 | 23335409 |
| computational analysis of bacterial rna-seq data. | recent advances in high-throughput rna sequencing (rna-seq) have enabled tremendous leaps forward in our understanding of bacterial transcriptomes. however, computational methods for analysis of bacterial transcriptome data have not kept pace with the large and growing data sets generated by rna-seq technology. here, we present new algorithms, specific to bacterial gene structures and transcriptomes, for analysis of rna-seq data. the algorithms are implemented in an open source software system c ... | 2013 | 23716638 |
| oral toxicity of photorhabdus luminescens and xenorhabdus nematophila (enterobacteriaceae) against aedes aegypti (diptera: culicidae). | dengue fever is an important vector-borne disease, mainly transmitted by aedes aegypti. to date, there are no vaccines or effective drugs available against this arboviral disease. as mosquito control is practically the only method available to control dengue fever, alternative and cost-effective pest control strategies need to be explored. the gram-negative enteric bacteria xenorhabdus and photorhabdus are symbiotically associated with nematode parasites, which themselves are highly pathogenic f ... | 2013 | 23728731 |
| expression, purification, and functional characterization of atypical xenocin, its immunity protein, and their domains from xenorhabdus nematophila. | xenorhabdus nematophila, a gram-negative bacterium belonging to the family enterobacteriaceae is a natural symbiont of a soil nematode from the family steinernematidae. in this study cloning, expression, and purification of broad range iron regulated multidomain bacteriocin called xenocin from x. nematophila (66 kda, encoded by xcina gene) and its multidomain immunity protein (42 kda, encoded by ximb gene) have been done. xcina-ximb (n' terminal 270 bp), translocation, and translocation-receptor ... | 2013 | 26904727 |
| rhabdopeptides as insect-specific virulence factors from entomopathogenic bacteria. | six novel linear peptides, named "rhabdopeptides", have been identified in the entomopathogenic bacterium xenorhabdus nematophila after the discovery of the corresponding rdp gene cluster by using a promoter trap strategy for the detection of insect-inducible genes. the structures of these rhabdopeptides were deduced from labeling experiments combined with detailed ms analysis. detailed analysis of an rdp mutant revealed that these compounds participate in virulence towards insects and are produ ... | 2013 | 24038745 |