Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| the 23-valent pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis: a double-blinded, randomized, placebo-controlled trial. | pneumococcal pneumonia is the most frequent form of pneumonia. we herein assessed the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (ppsv23) in the prevention of pneumonia overall in rheumatoid arthritis (ra) patients at risk for infections. we hypothesized that ppsv23 vaccination is superior in preventing pneumococcal pneumonia compared with placebo in ra patients. | 2017 | 28122642 |
| prospective surveillance of healthcare associated infections in a cambodian pediatric hospital. | healthcare associated infections (hai) are the most common preventable adverse events following admission to healthcare facilities. data from low-income countries are scarce. we sought to prospectively define hai incidence at angkor hospital for children (ahc), a cambodian pediatric referral hospital. | 2017 | 28138385 |
| evaluation of three sample preparation methods for the direct identification of bacteria in positive blood cultures by maldi-tof. | patient mortality is significantly reduced by rapid identification of bacteria from sterile sites. maldi-tof can identify bacteria directly from positive blood cultures and multiple sample preparation methods are available. we evaluated three sample preparation methods and two maldi-tof score cut-off values. positive blood culture bottles with organisms present in gram stains were prospectively analysed by maldi-tof. three lysis reagents (saponin, sds, and sepsityper lysis bufer) were applied to ... | 2017 | 28100271 |
| recurrent pneumonia among japanese adults: disease burden and risk factors. | in japan and other societies with rapidly aging populations, recurrent pneumonia (rp) is a major clinical problem yet only limited information exists regarding the burden of this disease. | 2017 | 28077107 |
| secondary metabolites from bacillus amyloliquefaciens isolated from soil can kill burkholderia pseudomallei. | bacillus species are gram-positive bacteria found in abundance in nature and their secondary metabolites were found to possess various potential activities, notably antimicrobial. in this study, bacillus amyloliquefaciens n2-4 and n3-8 were isolated from soil and their metabolites could kill burkholderia pseudomallei, a gram-negative pathogenic bacterium also found in soil in its endemic areas. moreover, the metabolites were able to kill drug resistant isolates of b. pseudomallei and also inhibi ... | 2017 | 28050857 |
| can contaminated water be rendered safe for nasal saline irrigations? | to compare sterile water to three methods of sterilization (carbon filtration, boiling, and ultraviolet [uv] light) for preparation of nasal saline irrigants free of bacterial and amebic contaminants. | 2017 | 28224696 |
| next-generation sequencing combined with specific pcr assays to determine the bacterial 16s rrna gene profiles of middle ear fluid collected from children with acute otitis media. | the aim of the study was to analyze the bacteriome of acute otitis media with a novel modification of next-generation sequencing techniques. outpatient children with acute otitis media were enrolled in the study, and middle ear fluids were collected during 90 episodes from 79 subjects aged 5 to 42 months (median age, 19 months). the bacteriome profiles of middle ear fluid samples were determined by a nested-pcr amplification of the 16s rrna gene (v4 region), followed by mass sequencing. the prof ... | 2017 | 28357413 |
| microbiology of otitis media in indigenous australian children: review. | to review research addressing the polymicrobial aetiology of otitis media in indigenous australian children in order to identify research gaps and inform best practice in effective prevention strategies and therapeutic interventions. | 2017 | 28088924 |
| fluorocycline tp-271 is potent against complicated community-acquired bacterial pneumonia pathogens. | tp-271 is a novel, fully synthetic fluorocycline antibiotic in clinical development for the treatment of respiratory infections caused by susceptible and multidrug-resistant pathogens. tp-271 was active in mic assays against key community respiratory gram-positive and gram-negative pathogens, including streptococcus pneumoniae (mic90 = 0.03 µg/ml), methicillin-sensitive staphylococcus aureus (mssa; mic90 = 0.25 µg/ml), methicillin-resistant s. aureus (mrsa; mic90 = 0.12 µg/ml), streptococcus pyo ... | 2017 | 28251179 |
| antibacterial screening of rumex species native to the carpathian basin and bioactivity-guided isolation of compounds from rumex aquaticus. | plants belonging to the genus rumex (family polygonaceae) are used worldwide in traditional medicine for the treatment of various diseases caused by different microorganisms (e.g. bacteria-related dermatologic conditions, dysentery and enteritis). the present study focused on the antibacterial screening of rumex species native to the carpathian basin, and isolation of compounds from one of the most efficient species, rumex aquaticus. the antibacterial effects of n-hexane, chloroform and aqueous ... | 2017 | 28300698 |
| surveillance of omadacycline activity tested against clinical isolates from a global (north america, europe, latin america and asia-western pacific) collection (2010-2011). | omadacycline is a broad spectrum aminomethylcycline in late-stage clinical development for acute bacterial skin and skin structure infections and community-acquired pneumonia as both an oral and intravenous, once-daily formulation. in this report omadacycline and comparators were tested against 69,246 non-duplicate bacterial isolates collected prospectively during 2010 and 2011 from medical centers in asia-pacific (11,397 isolates), europe (23,490 isolates), latin america (8,038 isolates) and no ... | 2017 | 28223386 |
| panel 6: vaccines. | objective to review the literature on progress regarding (1) effectiveness of vaccines for prevention of otitis media (om) and (2) development of vaccine antigens for om bacterial and viral pathogens. data sources pubmed database of the national library of science. review methods we performed literature searches in pubmed for om pathogens and candidate vaccine antigens, and we restricted the searches to articles in english that were published between july 2011 and june 2015. panel members review ... | 2017 | 28372533 |
| the role of acute and chronic respiratory colonization and infections in the pathogenesis of copd. | copd is a major global concern, increasingly so in the context of ageing populations. the role of infections in disease pathogenesis and progression is known to be important, yet the mechanisms involved remain to be fully elucidated. while copd pathogens such as haemophilus influenzae, moraxella catarrhalis and streptococcus pneumoniae are strongly associated with acute exacerbations of copd (aecopd), the clinical relevance of these pathogens in stable copd patients remains unclear. immune respo ... | 2017 | 28342288 |
| il-33/st2 immune responses to respiratory bacteria in pediatric asthma. | here we investigated the relationship between local bacterial colonization and anti-bacterial immune responses in pre-school asthmatic and control children within the eu-wide study predicta. in this cohort of pre-school asthmatic children, nasopharyngeal colonization with gram-negative bacteria such as haemophilus influenzae and moraxella catarrhalis was found to be associated with the highest interferon beta (ifnβ) and il-33 levels in the nasal pharyngeal fluids (npf). il33r-st2 was found induc ... | 2017 | 28262704 |
| design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. | erythromycin was long viewed as a bacteriostatic agent. the erythromycin derivatives, 9-oxime ketolides have a species-specific bactericidal profile. among them, the 3'-allyl version of the 9-oxime ketolide 1 (ar=3-quinolyl; 17a) is bactericidal against streptococcus pneumoniae and streptococcus pyogenes. in contrast, the 2-fluoro analogs of 1, 13a (ar=6-quinolyl), 13b (ar=3-quinolyl) and 24a (ar=4-isoquinolyl), show bactericidal activities against s. pneumoniae, staphylococcus aureus and moraxe ... | 2017 | 28256375 |
| simultaneous detection of nine key bacterial respiratory pathogens using luminex xtag(®) technology. | early diagnosis and treatment are crucial to the outcome of lower respiratory tract infections (lrtis). in this study, we developed an assay combining multiplex pcr and luminex technology (mplt) for the detection of nine important respiratory bacterial pathogens, which frequently cause lrtis. these were streptococcus pneumoniae, moraxella catarrhalis, staphylococcus aureus, streptococcus pyogenes, haemophilus influenzae, mycoplasma pneumoniae, legionella spp., pseudomonas aeruginosa, and klebsie ... | 2017 | 28241513 |
| comparison of pathogen eradication rate and safety of anti-bacterial agents for bronchitis: a network meta-analysis. | a large number of population in both developing and developed countries are affected by bronchitis, among all the factors, bacterial infection was considered as a critical cause of acute exacerbations of chronic bronchitis. although several anti-bacterial agents were proved to have the effect of alleviating bronchitis, their relative efficacies and potential side effects remained not clear. we are keen to compare the pathogen eradication rate and safety of anti-bacterial agents for bronchitis. | 2017 | 28230273 |
| do we need a vaccine against moraxella catarrhalis in chronic lung disease? what are the options and opportunities? | moraxella catarrhalis is the second most common cause of exacerbations in adults with copd, resulting in enormous morbidity and mortality in this clinical setting. vaccine development for m. catarrhalis has lagged behind the other two important causes of exacerbations in copd, nontypeable haemophilus influenzae and streptococcus pneumoniae. while no licensed vaccine is currently available for m. catarrhalis, several promising candidate vaccine antigens have been identified and characterized and ... | 2017 | 28185742 |
| longitudinal assessment of sputum microbiome by sequencing of the 16s rrna gene in non-cystic fibrosis bronchiectasis patients. | bronchiectasis is accompanied by chronic bronchial infection that may drive disease progression. however, the evidence base for antibiotic therapy is limited. dna based methods offer better identification and quantification of microbial constituents of sputum than standard clinical culture and may help inform patient management strategies. our study objective was to determine the longitudinal variability of the non-cystic fibrosis (cf) bronchiectasis microbiome in sputum with respect to clinical ... | 2017 | 28170403 |
| seasonal patterns and association of meteorological factors with infection caused by streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis in childhood community-acquired pneumonia in a tropical region. | 2017 | 27464260 | |
| prelp enhances host innate immunity against the respiratory tract pathogen moraxella catarrhalis. | respiratory tract infections are one of the leading causes of mortality worldwide urging better understanding of interactions between pathogens causing these infections and the host. here we report that an extracellular matrix component proline/arginine-rich end leucine-rich repeat protein (prelp) is a novel antibacterial component of innate immunity. we detected the presence of prelp in human bronchoalveolar lavage fluid and showed that prelp can be found in alveolar fluid, resident macrophages ... | 2017 | 28148731 |
| prospective evaluation of the aetiology of acute otitis media with spontaneous tympanic membrane perforation. | to evaluate the aetiological role of the main bacterial pathogens associated with acute otitis media (aom) in children with aom and spontaneous tympanic membrane perforation (stmp). | 2017 | 28110050 |
| aqueous humor antimicrobial activity: in vitro analysis after topical 0.5% chloramphenicol application. | to assess aqueous humor antimicrobial activity in vitro after topical 0.5% chloramphenicol application. | 2017 | 28085501 |
| nasopharyngeal carriage of respiratory pathogens in warao amerindians: significant relationship with stunting. | to assess risk factors for nasopharyngeal carriage of potential pathogens in geographically isolated warao amerindians in venezuela. | 2017 | 28072501 |
| recent epidemiology of streptococcus pneumoniae in nasopharynxes of korean children with acute otitis media. | this prospective study was performed to evaluate serotype distribution, multilocus sequence typing, and antibiotic susceptibility of streptococcus pneumoniae identified in korean children with acute otitis media (aom) after the introduction of a 7-valent pneumococcal conjugate vaccine (pcv7). | 2017 | 28024738 |
| deciphering upper respiratory tract microbiota complexity in healthy calves and calves that develop respiratory disease using shotgun metagenomics. | bovine respiratory disease (brd) is a multifactorial disorder responsible for severe economic losses in dairy and feedlot herds. advances in next-generation sequencing mean that microbial communities in clinical samples, including non-culturable bacteria, can be characterized. our aim was to evaluate the microbiota of the upper respiratory tract of healthy calves and calves with brd using whole-genome sequencing (shotgun metagenomics). we performed deep nasopharyngeal swabs on 16 holstein heifer ... | 2017 | 27988122 |
| moraxella catarrhalis meningitis during certolizumab pegol treatment. | 2017 | 28336117 | |
| moraxella catarrhalis macrolide-resistant isolates are highly concentrated in two mlst clonal complexes -ccn10 and cc363. | to gain some insights into the molecular evolution of moraxella catarrhalis macrolide resistance, pcr and sequencing analysis of the 23s rrna gene, copb typing and multilocus sequence typing (mlst) were performed on 181 m. catarrhalis isolates. the isolates were obtained from children (n = 47) and adults (n = 134) presenting with respiratory disease in the years 2010-2014. macrolide resistance was highly age-related, and nucleotide position alterations at a2330t could be detected in all macrolid ... | 2017 | 28239374 |
| oral microbiota in infants fed a formula supplemented with bovine milk fat globule membranes - a randomized controlled trial. | in a recent study, supplementation of infant formula with milk fat globule membranes (mfgm) decreased the incidence of otitis media in infants <6 months of age. | 2017 | 28099499 |
| acyl chain preference and inhibitor identification of moraxella catarrhalis lpxa: insight through crystal structure and computational studies. | lipopolysaccharide (lps) is an important surface component and a potential virulence factor in the pathogenesis of gram-negative bacteria. udp-n-acetylglucosamine acyltransferase (lpxa) enzyme catalyzes the first reaction of lps biosynthesis, reversible transfer of r-3-hydroxy-acyl moiety from donor r-3-hydroxy-acyl-acyl carrier protein to the 3' hydroxyl position of udp-n-acetyl-glucosamine. lpxa enzyme's essentiality in bacterial survival and absence of any homologous protein in humans makes i ... | 2017 | 28057571 |
| a genoproteomic approach to detect peptide markers of bacterial respiratory pathogens. | rapid identification of respiratory pathogens may facilitate targeted antimicrobial therapy. direct identification of bacteria in bronchoalveolar lavage (bal) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry is confounded by interfering substances. we describe a method to identify unique peptide markers of 5 gram-negative bacteria by liquid chromatography-tandem mass spectrometry (lc-ms/ms) for direct pathogen identification in bal. | 2017 | 28588123 |
| alloiococcus otitidis forms multispecies biofilm with haemophilus influenzae: effects on antibiotic susceptibility and growth in adverse conditions. | otitis media with effusion (ome) is a biofilm driven disease and commonly accepted otopathogens, such as haemophilus influenzae, streptococcus pneumonia, and moraxella catarrhalis, have been demonstrated to form polymicrobial biofilms within the middle ear cleft. however, alloiococcus otitidis (a. otitidis), which is one of the most commonly found bacteria within middle ear aspirates of children with ome, has not been described to form biofilms. the aim of this study was to investigate whether a ... | 2017 | 28824879 |
| the bacterial species associated with aspirated foreign bodies in children. | inhaled foreign bodies in children are common and may be complicated by secondary airway tract infection. the inhaled foreign body may act as carrier of infectious material and the aim of this study was to explore the bacterial species associated with aspirated foreign bodies in a cohort of children. | 2017 | 28779997 |
| investigation of antimicrobial, antioxidant, and xanthine oxidase--inhibitory activities of phellinus (agaricomycetes) mushroom species native to central europe. | ten representative central european phellinoid hymenochaetaceae species (phellinus sensu lato) were selected to examine their potential pharmacological activity. in this study 40 organic (n-hexane, chloroform, 50% methanol) and aqueous extracts with different polarities were analyzed for their antimicrobial, antioxidant, and xanthine oxidase (xo)--inhibitory properties. fomitiporia robusta, fuscoporia torulosa, phellopilus nigrolimitatus, and porodaedalea chrysoloma showed moderate antibacterial ... | 2017 | 28845768 |
| synthesis and antimicrobial activity of chiral quaternary n-spiro ammonium bromides with 3',4'-dihydro-1'h-spiro[isoindoline-2,2'-isoquinoline] skeleton. | a new class of highly functionalized tetrahydroisoquinolines with a quaternary carbon stereocenter was synthesized starting from an easily accessible l-tartaric acid. nine strains of bacteria (staphylococcus aureus, streptococcus pyogenes, streptococcus mutans, streptococcus salivarius, bacillus subtilis, enterococcus faecalis, moraxella catarrhalis, escherichia coli, campylobacter jejuni) were used for the determination of minimal inhibitory concentration (mic) and minimal bactericidal concentr ... | 2017 | 28740363 |
| simultaneous detection of 13 key bacterial respiratory pathogens by combination of multiplex pcr and capillary electrophoresis. | lower respiratory tract infections continue to pose a significant threat to human health. it is important to accurately and rapidly detect respiratory bacteria. to compensate for the limits of current respiratory bacteria detection methods, we developed a combination of multiplex polymerase chain reaction (pcr) and capillary electrophoresis (mpce) assay to detect thirteen bacterial pathogens responsible for lower respiratory tract infections, including streptococcus pneumoniae, haemophilus influ ... | 2017 | 28807095 |
| [a case of coccidioidomycosis in turkey imported from the united states of america]. | coccidioidomycosis caused by coccidioides immitis or coccidioides posadasii is a rare infectious disease except in endemic regions. in this report the third documented imported case of coccidioidomycosis in turkey was presented. a thirty-year-old male patient was admitted to our hospital with fever and purulent drainage from his chest tube. he had worked in arizona, usa, until 4 months before this presentation. while in arizona, he experienced cough and hemoptysis and was diagnosed as pulmonary ... | 2017 | 28566083 |
| identification of a large family of slam-dependent surface lipoproteins in gram-negative bacteria. | the surfaces of many gram-negative bacteria are decorated with soluble proteins anchored to the outer membrane via an acylated n-terminus; these proteins are referred to as surface lipoproteins or slps. in neisseria meningitidis, slps such as transferrin-binding protein b (tbpb) and factor-h binding protein (fhbp) are essential for host colonization and infection because of their essential roles in iron acquisition and immune evasion, respectively. recently, we identified a family of outer membr ... | 2017 | 28620585 |
| antimicrobial susceptibility of bacterial isolates from patients presenting with ear, nose and throat (ent) infections in the german community healthcare setting. | empiric initial antibiotic therapy of bacterial infections is based primarily upon the susceptibility of the most common causative pathogens. the purpose of this study was to provide susceptibility data on six bacterial species known to cause ear, nose and throat (ent) infections. a total of 1066 isolates collected during a nationwide laboratory-based surveillance study were analysed. all streptococcus pyogenes isolates were penicillin (pen)-susceptible, indicating that natural penicillins can s ... | 2017 | 28429163 |
| typing and characterization of bacteria using bottom-up tandem mass spectrometry proteomics. | methods for rapid and reliable microbial identification are essential in modern healthcare. the ability to detect and correctly identify pathogenic species and their resistance phenotype is necessary for accurate diagnosis and efficient treatment of infectious diseases. bottom-up tandem mass spectrometry (ms) proteomics enables rapid characterization of large parts of the expressed genes of microorganisms. however, the generated data are highly fragmented, making downstream analyses complex. her ... | 2017 | 28420677 |
| differences of lung microbiome in patients with clinically stable and exacerbated bronchiectasis. | molecular-based diagnostic techniques can compensate for the inherent limitations of culture-based microbiology and provide a more comprehensive description of an entire community of bacteria at a particular anatomical site. using culture-independent dna-based molecular techniques, the aim of the present study was to characterize, differentiate, and compare the composition of lower airway bacterial microbiome between clinically stable and acutely infected patients with bronchiectasis experiencin ... | 2017 | 28829833 |
| bacteriological incidence in pneumonia patients with pulmonary emphysema: a bacterial floral analysis using the 16s ribosomal rna gene in bronchoalveolar lavage fluid. | pulmonary emphysema is an important radiological finding in chronic obstructive pulmonary disease patients, but bacteriological differences in pneumonia patients according to the severity of emphysematous changes have not been reported. therefore, we evaluated the bacteriological incidence in the bronchoalveolar lavage fluid (balf) of pneumonia patients using cultivation and a culture-independent molecular method. japanese patients with community-acquired pneumonia (83) and healthcare-associated ... | 2017 | 28790814 |
| epidemiology of acute otitis media in the postpneumococcal conjugate vaccine era. | to study the epidemiology of acute otitis media (aom), especially the otitis-prone condition, during the pneumococcal conjugate vaccines 7 and 13 era. | 2017 | 28784702 |
| serum antibody response to moraxella catarrhalis proteins in stringently defined otitis prone children. | moraxella catarrhalis (mcat) is a frequent pathogen of acute otitis media (aom) in young children. here we prospectively assessed naturally-induced serum antibodies to four mcat vaccine candidate proteins in stringently defined otitis prone (sop) and non-otitis prone (nop) children age 6-36months old following nasopharyngeal (np) colonization, at onset of aom and convalescence from aom. | 2017 | 28755833 |
| determining optimal dosing regimen of oral administration of dicloxacillin using monte carlo simulation. | dicloxacillin, a semisynthetic isoxazolyl penicillin, exhibits antimicrobial activity against a wide variety of gram-positive bacteria, as well as stability against penicillinases and low level of toxicity. the objective of this study was to obtain optimal dosing regimen of oral administration of dicloxacillin by analyzing the pharmacokinetic (pk) index in healthy volunteers and in vitro antibacterial activity by using monte carlo simulation. | 2017 | 28721014 |
| acute otitis media in children. | acute otitis media is a common childhood infection. prompt diagnosis and appropriate treatment are very important. | 2017 | 28707578 |
| nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of japanese society of chemotherapy, the japanese association for infectious diseases, and the japanese society for clinical microbiology in 2012: general view of the pathogens' antibacterial susceptibility. | the nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from the patients in japan was conducted by japanese society of chemotherapy, japanese association for infectious diseases and japanese society for clinical microbiology in 2012. the isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period between january and december in 2012 by three societies. antimicrobial suscept ... | 2017 | 28669567 |
| 10-valent pneumococcal conjugate vaccine (pcv10) decreases metabolic activity but not nasopharyngeal carriage of streptococcus pneumoniae and haemophilus influenzae. | the effect of pneumococcal vaccination is widely variable when measured by nasopharyngeal carriage of vaccine and non-vaccine targets. the aim of this study was to compare the carriage rates and metabolic activity of streptococcus pneumoniae, staphylococcus aureus, haemophilus influenzae and moraxella catarrhalis among children who were or were not vaccinated with pcv10. | 2017 | 28668567 |
| infection by streptococcus pneumoniae in children with or without radiologically confirmed pneumonia. | community-acquired pneumonia is an important cause of morbidity in childhood, but the detection of its causative agent remains a diagnostic challenge. the authors aimed to evaluate the role of the chest radiograph to identify cases of community-aquired pneumonia caused by typical bacteria. | 2017 | 28668258 |
| streptococcus pneumoniae otitis media pathogenesis and how it informs our understanding of vaccine strategies. | this study aimed to review the literature regarding the mechanisms of transition from asymptomatic colonization to induction of otitis media and how the insight into the pathogenesis of otitis media has the potential to help design future otitis media-directed vaccines. | 2017 | 28616365 |
| colonization density of the upper respiratory tract as a predictor of pneumonia-haemophilus influenzae, moraxella catarrhalis, staphylococcus aureus, and pneumocystis jirovecii. | there is limited information on the association between colonization density of upper respiratory tract colonizers and pathogen-specific pneumonia. we assessed this association for haemophilus influenzae, moraxella catarrhalis, staphylococcus aureus, and pneumocystis jirovecii. | 2017 | 28575367 |
| bronchial inflammation and bacterial load in stable copd is associated with tlr4 overexpression. | toll-like receptors (tlrs) and nucleotide-binding oligomerisation domain (nod)-like receptors (nlrs) are two major forms of innate immune sensors but their role in the immunopathology of stable chronic obstructive pulmonary disease (copd) is incompletely studied. our objective here was to investigate tlr and nlr signalling pathways in the bronchial mucosa in stable copd.using immunohistochemistry, the expression levels of tlr2, tlr4, tlr9, nod1, nod2, cd14, myeloid differentiation primary respon ... | 2017 | 28536249 |
| budesonide, fluticasone propionate, and azithromycin do not modulate the membrane vesicle release by thp-1 macrophages and respiratory pathogens during macrophage infection. | patients with more severe chronic obstructive pulmonary disease frequently experience exacerbations and it is estimated that up to 50% of these exacerbations are associated with bacterial infections. the mainstay treatment for these infection-related exacerbations constitutes the administration of glucocorticoids, alone or in combination with antibiotics. a recent line of evidence demonstrates that many hormones including the steroid beclomethasone can also directly affect bacterial growth, viru ... | 2017 | 28528362 |
| development of immunochromatographic colloidal gold test strip for rapid detection of haemophilus influenzae in clinical specimens. | a simple and fast test strip for simultaneous detection of haemophilus influenzae, based on the theory of colloidal gold immunochromatography was developed. | 2017 | 28497596 |
| bacteria isolated from the airways of paediatric patients with bronchiectasis according to hiv status. | knowledge of which bacteria are found in the airways of paediatric patients with bronchiectasis unrelated to cystic fibrosis (cf) is important in defining empirical antibiotic guidelines for the treatment of acute infective exacerbations. | 2017 | 28492126 |
| surveillance of the activity of solithromycin (cem-101) against bacteria from respiratory tract infections. | the activity of solithromycin, a fourth-generation macrolide and novel fluoroketolide, was evaluated by determining its minimum inhibitory concentration (mic) (via clinical and laboratory standards institute broth microdilution) against 2797 contemporary clinical respiratory tract isolates collected from north america, europe, asia-pacific and other regions of the world in 2012-13. solithromycin was very active against streptococcus pneumoniae and streptococcus pyogenes, with mic90 of 0.25 and 0 ... | 2017 | 28483717 |
| effect of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage by respiratory pathogens among greenlandic children. | in 2010, greenland introduced the 13-valent pneumococcal conjugate vaccine (prevnar 13®- pcv-13) in the childhood immunisation program. the authors aimed to evaluate the impact of pcv-13 on nasopharyngeal carriage of bacteria frequently associated with respiratory infections in children. | 2017 | 28467237 |
| effects of n-acetyl-l-cysteine on the membrane vesicle release and growth of respiratory pathogens. | bacterial infections contribute to the disease progression of chronic obstructive pulmonary disease by stimulating mucus production in the airways. this increased mucus production and other symptoms are often alleviated when patients are treated with mucolytics such as n-acetyl-l-cysteine (nac). moreover, nac has been suggested to inhibit bacterial growth. bacteria can release membrane vesicles (mvs) in response to stress, and recent studies report a role for these proinflammatory mvs in the pat ... | 2017 | 28444395 |
| a prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in copd. | the aetiology of acute exacerbations of copd (aecopd) is incompletely understood. understanding the relationship between chronic bacterial airway infection and viral exposure may explain the incidence and seasonality of these events. | 2017 | 28432209 |
| etiological analysis and epidemiological comparison among adult cap and nhcap patients in okinawa, japan. | etiological epidemiology and diagnosis are important issues for cap and nhcap. despite the availability of effective therapies, significant morbidity and mortality ensues. | 2017 | 28431934 |
| nasopharyngeal polymicrobial colonization during health, viral upper respiratory infection and upper respiratory bacterial infection. | we sought to understand how polymicrobial colonization varies during health, viral upper respiratory infection (uri) and acute upper respiratory bacterial infection to understand differences in infection-prone vs. non-prone patients. | 2017 | 28412081 |
| nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases. | we reported defective efferocytosis associated with cigarette smoking and/or airway inflammation in chronic lung diseases, including chronic obstructive pulmonary disease, severe asthma, and childhood bronchiectasis. we also showed defects in phagocytosis of nontypeable haemophilus influenzae (nthi), a common colonizer of the lower airway in these diseases. these defects could be substantially overcome with low-dose azithromycin; however, chronic use may induce bacterial resistance. the aim of t ... | 2017 | 28258107 |
| preferential aerosolization of bacteria in bioaerosols generated in vitro. | little is known about how bacteria are aerosolized in terms of whether some bacteria will be found in the air more readily than others that are present in the source. this report describes in vitro experiments to compare aerosolization rates (also known as preferential aerosolization) of gram-positive and gram-negative bacteria as well as rod- and coccus-shaped bacteria, using two nebulization conditions. | 2017 | 28632907 |
| a moraxella catarrhalis vaccine to protect against otitis media and exacerbations of copd: an update on current progress and challenges. | moraxella catarrhalis is a major cause of morbidity and mortality worldwide, especially causing otitis media in young children and exacerbations of chronic obstructive pulmonary disease in adults. this pathogen employs several virulence mechanisms to colonize and survive in its host, including adherence and invasion of host cells, formation of polymicrobial biofilms with other bacterial pathogens and production of beta-lactamase. given the global impact of otitis media and copd, an effective vac ... | 2017 | 28853985 |
| stringently defined otitis prone children demonstrate deficient naturally induced mucosal antibody response to moraxella catarrhalis proteins. | moraxella catarrhalis (mcat) is a prominent mucosal pathogen causing acute otitis media (aom). we studied mcat nasopharyngeal (np) colonization, aom frequency and mucosal antibody responses to four vaccine candidate mcat proteins: outer membrane protein (omp) cd, oligopeptide permease (opp) a, hemagglutinin (hag), and pilin a clade 2 (pila2) from stringently defined otitis prone (sop) children, who experience the greatest burden of disease, compared to non-otitis prone (nop) children. sop childr ... | 2017 | 28848555 |
| molecular characterization of fluoroquinolone-resistant moraxella catarrhalis variants generated in vitro by stepwise selection. | moraxella catarrhalis causes respiratory infections. in this study, fluoroquinolone-resistant strains were selected in vitro to evaluate the mechanism of fluoroquinolone resistance. strains with reduced fluoroquinolone susceptibility were obtained by stepwise selection in levofloxacin, and fluoroquinolone targets, gyr and par, were sequenced. six novel mutations in gyra (d84y, t594dup, and a722dup), gyrb (e479k and d439n), and pare (q395r) involved in m. catarrhalis resistance to fluoroquinolone ... | 2017 | 28760904 |
| treatment challenges of group a beta-hemolytic streptococcal pharyngo-tonsillitis. | introduction despite its in vitro efficacy, penicillin often fails to eradicate group a β-hemolytic streptococci (gabhs) from patients with acute and relapsing pharyngo-tonsillitis (pt). objective this review of the literature details the causes of penicillin failure to eradicate gabhs pt and the therapeutic modalities to reduce and overcome antimicrobial failure. data synthesis the causes of penicillin failure in eradicating gabhs pt include the presence of β lactamase producing bacteria (bl ... | 2017 | 28680500 |
| a cation-binding surface protein as a vaccine antigen to prevent moraxella catarrhalis otitis media and infections in chronic obstructive pulmonary disease. | moraxella catarrhalis is an exclusively human respiratory tract pathogen that is a common cause of otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease. a vaccine to prevent these infections would have a major impact in reducing the substantial global morbidity and mortality in these populations. through a genome mining approach, we identified afea, an ∼32 kda substrate binding protein of an abc transport system as an excellent candidate ... | 2017 | 28659326 |
| isogenic mutations in the moraxella catarrhalis cyddc system display pleiotropic phenotypes and reveal the role of a palindrome sequence in its transcriptional regulation. | moraxella catarrhalis is becoming an important human respiratory tract pathogen affecting significant proportions from the population. however, still little is known about its physiology and molecular regulation. to this end, the cyddc, which is a heterodimeric atp binding cassette transporter that has been shown to contribute to the maintenance of the redox homeostasis across the periplasm in other gram-negative bacteria, is studied here. amino acids multiple sequence alignments indicated that ... | 2017 | 28647125 |
| infection after total knee arthroplasty by m. catarrhalis associated with rheumatoid arthritis and dmards therapy. | moraxella catarrhalis is not commonly associated with prosthetic joint infection (pji). we present the first case of a patient with rheumatoid arthritis on certolizumab, an antitumor necrosis factor therapy, who developed pji following a total knee replacement. | 2017 | 28583061 |
| complete genome sequence of moraxella catarrhalis strain ccri-195me, isolated from the middle ear. | moraxella catarrhalis is an important bacterial pathogen that causes otitis media and exacerbations of chronic obstructive pulmonary disease. here, we report the complete genome sequence of m. catarrhalis strain ccri-195me, which contains the phase-variable epigenetic regulator modm3. | 2017 | 28546484 |
| colonisation of antibiotic resistant bacteria in a cohort of hiv infected children in ghana. | antibiotic use not only selects for resistance in pathogenic bacteria, but also in commensal flora of exposed individuals. little is known epidemiologically about antibiotic resistance in relation to people with hiv infection in sub-saharan africa. this study investigated the carriage of antibiotic resistant bacteria among hiv infected children at a tertiary hospital in ghana. one hundred and eighteen hiv positive children were recruited at the korle-bu teaching hospital in ghana and nasopharyng ... | 2017 | 28451037 |
| normal bacterial conjunctival flora in the huacaya alpaca (vicugna pacos). | to describe the bacterial flora of the normal conjunctiva of huacaya alpacas (vicugna pacos) and to determine the effect of age and gender on this flora. | 2016 | 25581469 |
| a rare case of recurrent frontal osteoma complicated by mucopyocele with an unusual organism, moraxella catarrhalis. | we report a rare case of recurrent frontal osteoma complicated by mucopyocele and intracranial abscess. furthermore, we report an unusual organism, moraxella catarrhalis, as the infectious agent. finally, we demonstrate that endovascular embolization may be part of the treatment paradigm of frontal osteomas in selected cases. | 2016 | 23202581 |
| antimicrobial susceptibility to β-lactam antibiotics and production of bro β-lactamase in clinical isolates of moraxella catarrhalis from a japanese hospital. | we investigated bro-β-lactamase production of moraxella catarrhalis isolates and its antimicrobial susceptibility to β-lactams. of the 233 isolates, 232 were bro producers and 224 were bro-1 producers. four isolates exhibited elevated ceftriaxone minimum inhibitory concentration (2 μg/ml) and different pulsed-field gel electrophoresis patterns and we expect this number to increase in the near future. | 2016 | 28057435 |
| pediatric rhinosinusitis. | rhinosinusitis, is defined as an inflammation of the paranasal and nasal sinus mucosae. chronic rhinosinusitis (crs)is a common problem in the pediatric age group and the diagnosis and treatment are challenging due to the chronicity and similarity of symptoms with allergic rhinitis and adenoid hypertrophy. although it is less common than acute rhinosinusitis, crs is becoming more frequent and significantly affects the quality of life in children and can substantially impair daily function. crs i ... | 2016 | 28042527 |
| synthesis and antimicrobial activity of nitrobenzyl-oxy-phenol derivatives. | two hydroquinone derivatives were prepared and their antimicrobial activity evaluated. their minimum inhibitory concentrations (mics) were determined using a broth dilution method. gentamycin and ciprofloxacin were used as reference antibiotics. the antimicrobial activity of 4-(benzyloxy)phenol (monobenzone) was also evaluated based on its structural similarity to the new compounds; activity was comparable to that of 3,5-dimethyl-4-((4-nitrobenzyl)oxy)phenol (4a). 2,3,5-trimethyl-4-((4-nitrobenz ... | 2016 | 27803461 |
| quantification of biofilm formation on silicone intranasal splints: an in vitro study. | biofilms are associated with persistent infections and resistant to conventional therapeutic strategies. the aim of this study was to investigate the quantity of biofilm produced on silicone intranasal splints. | 2016 | 27682847 |
| meningococcal pneumonia in japan: a case report and literature review. | neisseria meningitidis often causes meningitis and meningococcemia; however, meningococcal pneumonia is quite rare. herein, we report a case of non-invasive meningococcal pneumonia initially misdiagnosed as pneumonia due to moraxella catarrhalis on the basis of a gram stain in a 43-year-old woman with asthma, type 2 diabetes mellitus, and schizophrenia. she visited our hospital following a 3-day history of fever, productive cough, and shortness of breath. since her sputum smear revealed gram-neg ... | 2016 | 27591787 |
| [prevalence of moraxella catarrhalis in the nasopharyngeal specimen from 1 082 hospitalized children with respiratory infection and the drug resistance of the isolates]. | to investigate the prevalence of moraxella catarrhalis in the nasopharyngeal region of children with respiratory infection and the sensitivity of moraxella catarrhalis isolates to common antimicrobial drugs. | 2016 | 27530786 |
| profiling the membrane and glycosaminoglycan-binding proteomes of moraxella catarrhalis. | moraxella catarrhalis, a gram-negative bacterium, is an important respiratory pathogen causing acute otitis media and exacerbations of chronic obstructive pulmonary disease. adhesion of the pathogen to human epithelial cells is mediated via bacterial membrane adhesin proteins. to identify the surface proteome of moraxella catarrhalis, we applied different membrane protein extraction methods in combination with different proteomic technologies. proteins from preparations of outer membrane vesicle ... | 2016 | 27403532 |
| sulfate-binding protein, cysp, is a candidate vaccine antigen of moraxella catarrhalis. | moraxella catarrhalis causes otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease (copd). a vaccine to prevent m. catarrhalis infections would have an enormous impact globally in preventing morbidity caused by m. catarrhalis in these populations. using a genome mining approach we have identified a sulfate binding protein, cysp, of an atp binding cassette (abc) transporter system as a novel candidate vaccine antigen. cysp expresses epitope ... | 2016 | 27265455 |
| acute otitis media and other complications of viral respiratory infection. | viral upper and lower respiratory tract infections (uri, lri) are common in infants. we determined the prevalence of viral uri and its complications, including acute otitis media (aom) and lri, and assessed the effect of bacterial-viral interactions, and genetic and environmental risks on aom development. | 2016 | 27020793 |
| moraxella catarrhalis decreases antiviral innate immune responses by down-regulation of tlr3 via inhibition of p53 in human bronchial epithelial cells. | chronic obstructive pulmonary disease (copd) is complicated by infectious exacerbations with acute worsening of respiratory symptoms. coinfections of bacterial and viral pathogens are associated with more severe exacerbations. moraxella catarrhalis is one of the most frequent lower respiratory tract pathogens detected in copd. we therefore studied the impact of m. catarrhalis on the antiviral innate immune response that is mediated via tlr3 and p53. molecular interactions between m. catarrhalis ... | 2016 | 26979086 |
| immunoinformatics identifies a lactoferrin binding protein a peptide as a promising vaccine with a global protective prospective against moraxella catarrhalis. | moraxella catarrhalis is an established pathogen that is causing substantial infections to both children and adults. however, so far there is no effective vaccine to halt the spread of these infections. | 2016 | 26908723 |
| involvement of staphylococcus aureus and moraxella catarrhalis in japanese cedar pollinosis. | from mid february to the end of march, each year ∼30% of japanese have japanese cedar pollinosis. moreover, 10-50% of patients with this pollinosis exhibit nasal manifestations in the preseason. these patients have a predominance of neutrophils but not eosinophils in nasal swabs and high carriage of staphylococcus aureus. we hypothesized that s. aureus or other bacteria and associated neutrophilia were involved in preseasonal symptoms. | 2016 | 26877537 |
| moraxella catarrhalis evades host innate immunity via targeting cartilage oligomeric matrix protein. | moraxella catarrhalis is a respiratory tract pathogen commonly causing otitis media in children and acute exacerbations in patients suffering from chronic obstructive pulmonary disease. cartilage oligomeric matrix protein (comp) functions as a structural component in cartilage, as well as a regulator of complement activity. importantly, comp is detected in resident macrophages and monocytes, alveolar fluid, and the endothelium of blood vessels in lung tissue. we show that the majority of clinica ... | 2016 | 26712944 |
| using monte carlo simulation to determine optimal dosing regimen for cefetamet sodium for injection. | the objective of the study was to use monte carlo simulation to determine the optimal treatment dosing regimen of the cefetamet sodium for injection by analysing the pharmacokinetics (pk) parameters in healthy chinese volunteers, and antibacterial activity in vitro was also examined. a three-cross latin square single-dose pk study was designed. twelve healthy volunteers were randomized to receive 500, 1000, and 2000 mg of cefetamet sodium for iv infusion over 30 minutes in three periods sequenti ... | 2016 | 25252727 |
| ocular penetration of topical antibiotics: study on the penetration of chloramphenicol, tobramycin and netilmicin into the anterior chamber after topical administration. | to compare penetration in the aqueous humour of topically applied antibiotics. | 2016 | 23433257 |
| natural development of antibodies against streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis protein antigens during the first 13 years of life. | conserved protein antigens have been investigated as vaccine candidates against respiratory pathogens. we evaluated the natural development of antibodies against streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis proteins during childhood. serum samples were collected from 50 healthy children from their first months to age 13 years (median sampling interval, 6 months). we also analyzed serum samples from 24 adults. serum igg antibodies against eight pneumococcal proteins ... | 2016 | 27581439 |
| comparative in vitro activities of ceftaroline and ceftriaxone against bacterial pathogens associated with respiratory tract infections: results from the aware surveillance study. | ceftaroline fosamil is indicated for the treatment of community-acquired bacterial pneumonia and ceftriaxone has an indication for lower respiratory tract infections. this study was conducted to compare the relative in vitro activities of these two agents against bacterial species associated with community-associated respiratory tract infections. | 2016 | 27559120 |
| inflammation-associated cytokine analysis identifies presence of respiratory bacterial pathogens in the nasopharynx. | we sought to determine if inflammatory cytokines are induced during asymptomatic nasopharyngeal (np) colonization by the common respiratory bacteria streptococcus pneumoniae (spn), non-typeable haemophilus influenzae (nthi) and moraxella catarrhalis (mcat). 85 serum samples were studied from 85 children 6-36 months of age when children were healthy and potentially np colonized with spn, nthi or mcat. immunoassays were used to quantitate serum sicam-1, il-10 and s100a12 levels. logistic regressio ... | 2016 | 27493063 |
| the effects of live attenuated influenza vaccine on nasopharyngeal bacteria in healthy 2 to 4 year olds. a randomized controlled trial. | viral infections of the upper respiratory tract may influence the commensal nasopharyngeal bacteria. changes in the bacterial niche could affect transmission dynamics. attenuated vaccine viruses can be used to investigate this empirically in humans. | 2016 | 26742001 |
| nasopharyngeal carriage of streptococcus pneumoniae and other bacteria in the 7th year after implementation of the pneumococcal conjugate vaccine in the netherlands. | after introduction of the 7-valent pneumococcal conjugate vaccine (pcv7) in the infant national immunization program (nip) in the netherlands in 2006, streptococcus pneumoniae strains of the non-vaccine serotype 19a emerged and became the dominant serotype in carriage in children and their parents. similar patterns were observed in other european countries and the united states. increases in carriage rates of staphylococcus aureus and non-typeable (nt) haemophilus influenzae were also observed. ... | 2016 | 26667610 |
| impact of bacteria in nasal aspirates on disease severity of bronchiolitis. | the effect of potentially pathogenic bacteria (ppb) on disease severity in patients with bronchiolitis is understudied. | 2016 | 26365560 |
| in vitro activity of delafloxacin tested against isolates of streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis. | delafloxacin, an investigational anionic fluoroquinolone, is active against a broad range of gram-positive and gram-negative bacteria. in this study, 200 streptococcus pneumoniae (plus 30 levofloxacin-resistant isolates), 200 haemophilus influenzae, and 100 moraxella catarrhalis isolates selected primarily from the united states (2014) were tested against delafloxacin and comparator agents. delafloxacin was the most potent agent tested. mic50 and mic90 values against all s. pneumoniae isolates w ... | 2016 | 27458220 |
| prevalence and antimicrobial susceptibility of haemophilus influenzae and moraxella catarrhalis isolated from patients in bangkok, thailand. | 2016 | 27436474 | |
| antimicrobial susceptibility of streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis isolated from community-acquired respiratory tract infections in china: results from the cartips antimicrobial surveillance program. | this study investigated the antimicrobial susceptibilities of streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis isolates causing adult community-acquired respiratory tract infections (cartis) in china. a multicentre resistance surveillance study (cartips) investigating 1046 clinical isolates from 19 hospitals in china was conducted from 2013 to 2014. based on the minimum inhibitory concentration (mic) breakpoints of oral penicillin, the percentages of penicillin-resistan ... | 2016 | 27436464 |
| nasopharyngeal bacterial carriage in young children in greenland: a population at high risk of respiratory infections. | the incidence of childhood respiratory infections in greenland is among the highest globally. we performed a population-based study of 352 greenlandic children aged 0-6 years aiming to describe rates and risk factors for carriage of four key bacteria associated with respiratory infections, their antimicrobial susceptibility and inter-bacterial associations. nasopharyngeal swabs were tested for streptococcus pneumoniae grouped by serotypes included (vt) or not included (nvt) in the 13-valent pneu ... | 2016 | 27405603 |
| [evaluation of safety and efficacy of tebipenem pivoxil granules for pediatric in pneumonia, otitis media and sinusitis]. | we conducted a postmarketing surveillance of tebipenem pivoxil granules (orapenem® fine granules 10% for pediatric), an oral carbapenem antibacterial agent, between april 2010 and march 2013 to evaluate the safety and efficacy in patients with pneumonia or otitis media, or sinusitis of 3,547 patients enrolled, 3,540 from whom survey forms were collected were analyzed. of these 3,540 patients, there were a total of 3,331 patients included in the safety analysis, 2,844 in the efficacy analysis, 2, ... | 2016 | 27290830 |