Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| characterization of the efficiency and uncertainty of skimmed milk flocculation for the simultaneous concentration and quantification of water-borne viruses, bacteria and protozoa. | in this study, the use of skimmed milk flocculation (smf) to simultaneously concentrate viruses, bacteria and protozoa was evaluated. we selected strains of faecal indicator bacteria and pathogens, such as escherichia coli and helicobacter pylori. the viruses selected were adenovirus (hadv 35), rotavirus (rov sa-11), the bacteriophage ms2 and bovine viral diarrhoea virus (bvdv). the protozoa tested were acanthamoeba, giardia and cryptosporidium. the mean recoveries with q(rt)pcr were 66% (hadv 3 ... | 2017 | 28093213 |
| bacteria associated with marginal zone lymphomas. | in the last decades some bacteria have been associated with a various extent with marginal zone (extra nodal, nodal and splenic types) lymphomas are frequently associated with chronic infections, with important clinical, molecular, biological, and therapeutic implications. the well-known correlation between helicobacter pylori and gastric malt-lymphoma, the recently reported links between chlamydia psittaci and ocular adnexal malt-lymphoma and borrelia burgdorferi and cutaneous malt lymphoma con ... | 2017 | 28288714 |
| recombinant bacillus subtilis spores expressing cholera toxin b subunit and helicobacter pylori urease b confer protection against h. pylori in mice. | helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma. the limitations of current therapies for h. pylori infection include poor compliance and antibiotic resistance. therefore, an effective anti-h. pylori vaccine would be an alternative or complement to antibiotic treatment. urease b (ureb) is considered an ideal vaccine antigen against h. pylori infection. in this study, cholera toxin b subunit (ctb), a ... | 2017 | 27930268 |
| muts2 promotes homologous recombination in bacillus subtilis. | bacterial muts proteins are subdivided into two families, muts1 and muts2. muts1 family members recognize dna replication errors during their participation in the well-characterized mismatch repair (mmr) pathway. in contrast to the well-described function of muts1, the function of muts2 in bacteria has remained less clear. in helicobacter pylori and thermus thermophilus, muts2 has been shown to suppress homologous recombination. the role of muts2 is unknown in the gram-positive bacterium bacillu ... | 2017 | 27799325 |
| chemical characteristics, antimicrobial and cytotoxic activities of the essential oil of egyptian cinnamomum glanduliferum bark. | the essential oil isolated from the bark of cinnamomum glanduliferum (wall) meissn that grown in egypt was screened for the first time. the chemical composition was analyzed by gc and gc/mass. the antimicrobial activity of the oil was assessed using agar-well diffusion method toward representatives for each of gram-positive bacteria, gram-negative bacteria, and fungi. the cytotoxic activity was checked using three human cancer cell lines. twenty seven compounds were identified, representing 99.0 ... | 2017 | 28190283 |
| modeling diversity in structures of bacterial outer membrane lipids. | lipopolysaccharides (lpss) are vital components of the outer membrane of gram-negative bacteria, and they act as extremely strong stimulators of innate immunity in diverse eukaryotic species. the primary immunostimulatory center of the lps molecule is lipid a, a disaccharide-bound lipophilic domain. considering the broad diversity in bacterial species, there are variations in the lipid a structures and their immunogenic potencies. in this work, we model the lipid a structures of eight commensal ... | 2017 | 28080049 |
| collateral damage: insights into bacterial mechanisms that predispose host cells to cancer. | infections are estimated to contribute to 20% of all human tumours. viruses are known to induce cell transformation, but evidence has also linked bacteria, such as helicobacter pylori and salmonella enterica subsp. enterica serovar typhi, to different cancer types. in addition, chlamydia trachomatis, fusobacterium nucleatum and bacteroides fragilis are associated with the development of cancer, although a causal relationship has not yet been established. bacterial effectors such as colibactin an ... | 2017 | 28045107 |
| use of probiotics as an adjuvant to sequential h. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance. | to evaluate the effect of probiotics administered as an adjuvant to sequential helicobacter pylori (h. pylori) eradication therapy on treatment outcome and patient compliance. | 2017 | 28007678 |
| tannerella forsythia strains display different cell-surface nonulosonic acids: biosynthetic pathway characterization and first insight into biological implications. | tannerella forsythia is an anaerobic, gram-negative periodontal pathogen. a unique o-linked oligosaccharide decorates the bacterium's cell surface proteins and was shown to modulate the host immune response. in our study, we investigated the biosynthesis of the nonulosonic acid (nulo) present at the terminal position of this glycan. a bioinformatic analysis of t. forsythia genomes revealed a gene locus for the synthesis of pseudaminic acid (pse) in the type strain atcc 43037 while strains fdc 92 ... | 2017 | 27986835 |
| relationship between removable prosthesis and some systemics disorders. | this article reviews the dental literature concerning the potential impact of the removable prosthesis (rp) on the health status of patients with certain systemic diseases. literature was surveyed using medline/pubmed database resources, as well as a manual search, up to 2015 to identify appropriate articles that addressed the aim of this review. the research used keywords about associations between rp and six pathologies: human immunodeficiency virus infection, diabetes mellitus, pulmonary dise ... | 2017 | 26929530 |
| infectious burden and semen parameters. | to investigate the relationship between chronic infections detected in serum and semen quality. the pathogen burden is a concept consisting in the observation that, in patients with heart disease, damaging effects of the coronary arteries increase concomitantly with the number of agents responsible for chronic infections to which patients mounted a serological response. previous observations that helicobacter pylori infection may reduce the semen quality prompted us to perform the present study. | 2017 | 27793655 |
| risk factors for acute myocardial infarction in central india: a case-control study. | atherosclerosis is a multi-factorial disease involving the interplay of genetic and environmental factors. studies highlighting the public health importance of risk factors like chronic infections causing acute myocardial infarction (ami) in the indian context are scarce. this study was undertaken to study the association of socio-demographic and life-style factors with acute myocardial infarction in central india. | 2017 | 25657508 |
| ornithine decarboxylase regulates m1 macrophage activation and mucosal inflammation via histone modifications. | macrophage activation is a critical step in host responses during bacterial infections. ornithine decarboxylase (odc), the rate-limiting enzyme in polyamine metabolism, has been well studied in epithelial cells and is known to have essential roles in many different cellular functions. however, its role in regulating macrophage function during bacterial infections is not well characterized. we demonstrate that macrophage-derived odc is a critical regulator of m1 macrophage activation during both ... | 2017 | 28096401 |
| deprescribing versus continuation of chronic proton pump inhibitor use in adults. | proton pump inhibitors (ppis) are a class of medications that reduce acid secretion and are used for treating many conditions such as gastroesophageal reflux disease (gerd), dyspepsia, reflux esophagitis, peptic ulcer disease, and hypersecretory conditions (e.g. zollinger-ellison syndrome), and as part of the eradication therapy for helicobacter pylori bacteria. however, approximately 25% to 70% of people are prescribed a ppi inappropriately. chronic ppi use without reassessment contributes to p ... | 2017 | 28301676 |
| rapid diagnosis of gastrointestinal tract infections due to parasites, viruses, and bacteria. | rapid diagnostic techniques are valuable tools in the diagnosis of gastrointestinal infections, especially for the detection of some microorganisms and in certain groups of patients. while antigen detection techniques are widely used in clinical microbiology laboratories, for the diagnosis of viruses, some parasites and some bacteria, molecular techniques are routinely used only for some pathogens (such as clostridium difficile). however, molecular techniques are constantly evolving, and they al ... | 2017 | 28238506 |
| review of the role of probiotics in gastrointestinal diseases in adults. | probiotics may act as biological agents that modify the intestinal microbiota and certain cytokine profiles, which can lead to an improvement in certain gastrointestinal diseases. | 2017 | 28185664 |
| the mexican consensus on probiotics in gastroenterology. | probiotics are frequently prescribed in clinical practice. their efficacy in treating gastrointestinal disorders is supported by a significant number of clinical trials. however, the correct prescription of these agents is hampered due to a lack of knowledge of the scientific evidence and to the different presentations and microbial compositions of the probiotics that are currently available. | 2017 | 28104319 |
| targeting and alteration of tight junctions by bacteria and their virulence factors such as clostridium perfringens enterotoxin. | the integrity of tight junctions, which regulate paracellular permeability, is challenged by many bacterial pathogens. this is caused by inflammatory responses triggered by pathogens and direct interaction of bacteria or their toxins with host epithelial cells. in some cases, tight junction proteins represent receptors for cell surface proteins or toxins of the pathogen, such as clostridium perfringens enterotoxin (cpe). cpe causes diarrhea and cramps-the symptoms of a common foodborne illness, ... | 2017 | 27864644 |
| vitamin b12 deficiency: an important reversible co-morbidity in neuropsychiatric manifestations. | vitamin b12 deficiency is a common condition causing neurologic, cognitive, psychiatric, and mood symptoms. with varied religious, ethnic, and socioeconomic heterogeneity among the people in india greatly influencing their dietary habits and with the high prevalence of helicobacter pylori infection, vitamin b12 deficiency is not uncommon, but is often under recognized due to the lack of classical symptomatic presentation. | 2017 | 25722508 |
| finding novel antibiotic substances from medicinal plants - antimicrobial properties of nigella sativa directed against multidrug-resistant bacteria. | the progressive rise in multidrug-resistant (mdr) bacterial strains poses serious problems in the treatment of infectious diseases. while the number of newly developed antimicrobial compounds has greatly fallen, the resistance of pathogens against commonly prescribed drugs is further increasing. this rise in resistance illustrates the need for developing novel therapeutic and preventive antimicrobial options. the medicinal herb nigella sativa and its derivatives constitute promising candidates. ... | 2017 | 28386474 |
| disinfection and removal of human pathogenic bacteria in arctic waste stabilization ponds. | wastewater stabilization ponds (wsps) are commonly used to treat municipal wastewater in arctic canada. the biological treatment in the wsps is strongly influenced by climatic conditions. currently, there is limited information about the removal of fecal and pathogenic bacteria during the short cool summer treatment season. with relevance to public health, the objectives of this paper were to determine if treatment in arctic wsps resulted in the disinfection (i.e., removal of fecal indicator bac ... | 2017 | 28353112 |
| in situ structure of the legionella dot/icm type iv secretion system by electron cryotomography. | type iv secretion systems (t4sss) are large macromolecular machines that translocate protein and dna and are involved in the pathogenesis of multiple human diseases. here, using electron cryotomography (ect), we report the in situ structure of the dot/icm type ivb secretion system (t4bss) utilized by the human pathogen legionella pneumophila this is the first structure of a type ivb secretion system, and also the first structure of any t4ss in situ while the dot/icm system shares almost no seque ... | 2017 | 28336774 |
| structural characterization of purine nucleoside phosphorylase from human pathogen helicobacter pylori. | microaerophilic bacterium helicobacer pylori is a well known human pathogen involved in the development of many diseases. due to the evergrowing infection rate and increase of h. pylori antibiotic resistence, it is of utmost importance to find a new way to attack and eradicate h. pylori. the purine metabolism in h. pylori is solely dependant on the salvage pathway and one of the key enzymes in this pathway is purine nucleoside phosphorylase (pnp). in this timely context, we report here the basic ... | 2017 | 28336275 |
| cytokine changes in gastric and colonic epithelial cell in response to planta ovata extract. | background psyllium (planta ovata, ispaghul) seed and husk are used for treatment of altered bowel habit, i. e. constipation and diarrhea. we studied the effect of ispaghul extract on secretion of interleukin-1 beta (il-1β) by ags (atcc crl 1739) and sw480 (atcc ccl-227) epithelial cell lines and determined whether ispaghul extract has an effect on il-1β secretion by helicobacter pylori (h. pylori)-stimulated ags cell and escherichia coli k-12 (e. coli k-12)-stimulated sw480 cells in vitro. meth ... | 2017 | 28333654 |
| differential effects of deae negative mode chromatography and gel-filtration chromatography on the charge status of helicobacter pylori neutrophil-activating protein. | helicobacter pylori neutrophil-activating protein (hp-nap) is involved in h. pylori-associated gastric inflammation. hp-nap is also a vaccine candidate, a possible drug target, and a potential diagnostic marker for h. pylori-associated diseases. previously, we purified recombinant hp-nap by one-step diethylaminoethyl (deae) negative mode chromatography by collecting the unbound fraction at ph 8.0 at 4°c. it remains unclear why hp-nap does not bind to deae resins at the ph above its isoelectric p ... | 2017 | 28328957 |
| crystal structure of the type iv secretion system component cagx from helicobacter pylori. | helicobacter pylori, a gram-negative bacterial pathogen prevalent in the human population, is the causative agent of severe gastric diseases. an h. pylori type iv secretion (t4s) system encoded by the cytotoxin-associated gene pathogenicity island (cagpai) is responsible for communication with host cells. as a component of the cagpai t4s system core complex, cagx plays an important role in virulence-protein translocation into the host cells. in this work, the crystal structure of the c-terminal ... | 2017 | 28291753 |
| metabolic engineering of escherichia coli for the production of 2'-fucosyllactose and 3-fucosyllactose through modular pathway enhancement. | fucosyllactoses, including 2'-fucosyllactose (2'-fl) and 3-fucosyllactose (3-fl), are important oligosaccharides in human milk that are commonly used as nutritional additives in infant formula due to their biological functions, such as the promotion of bifidobacteria growth, inhibition of pathogen infection, and improvement of immune response. in this study, we developed a synthetic biology approach to promote the efficient biosynthesis of 2'-fl and 3-fl in engineered escherichia coli. to boost ... | 2017 | 28286292 |
| the prevention of benign prostatic hyperplasia (bph). | barry marshall and robin warren were the first to show that the chronic diseases (gastric ulcer and chronic gastritis) were caused by an infection (helicobacter pylori). the chronic disease benign prostatic hyperplasia belongs to the same ilk, except that the infection process is much more subtle and complex. the enzyme phospholipase d (pld) which is attached to the outer membrane of escherichia coli (e. coli) has now been almost completely proven to be the basic cause of bph. the evidence for t ... | 2017 | 28236846 |
| surface expression of helicobacter pylori hpaa adhesion antigen on vibrio cholerae, enhanced by co-expressed enterotoxigenic escherichia coli fimbrial antigens. | helicobacter pylori infection can cause peptic ulceration and is associated with gastric adenocarcinoma. this study aimed to construct and characterize a non-virulent vibrio cholerae o1 strain, which grows more rapidly than h. pylori, as vector for h. pylori antigens for possible use as a vaccine strain against h. pylori. this was done by recombinant expression of the h. pylori adhesion antigen hpaa alone or, as a proof of principle, together with different colonization factor (cf) antigens of e ... | 2017 | 28215587 |
| a novel design of a multi-antigenic, multistage and multi-epitope vaccine against helicobacter pylori: an in silico approach. | helicobacter pylori have colonized the gastric mucosa of half of the population worldwide. this bacterium is classified as a definitive type i carcinogen by the world health organization and no effective vaccine has been found against it yet. thus, a logical and rational vaccine design against h. pylori is necessary. because of its tremendous complexity and elicited immune responses, the vaccine design should considered multiple antigens to enhance immune-protection, involved in the different st ... | 2017 | 28185986 |
| crystal structure of the n-terminal anticodon-binding domain of the nondiscriminating aspartyl-trna synthetase from helicobacter pylori. | the n-terminal anticodon-binding domain of the nondiscriminating aspartyl-trna synthetase (nd-asprs) plays a crucial role in the recognition of both trna(asp) and trna(asn). here, the first x-ray crystal structure of the n-terminal domain of this enzyme (nd-asprs1-104) from the human-pathogenic bacterium helicobacter pylori is reported at 2.0 å resolution. the apo form of h. pylori nd-asprs1-104 shares high structural similarity with the n-terminal anticodon-binding domains of the discriminating ... | 2017 | 28177315 |
| recent advances in helicobacter pylori replication: possible implications in adaptation to a pathogenic lifestyle and perspectives for drug design. | dna replication is an important step in the life cycle of every cell that ensures the continuous flow of genetic information from one generation to the next. in all organisms, chromosome replication must be coordinated with overall cell growth. helicobacter pylori growth strongly depends on its interaction with the host, particularly with the gastric epithelium. moreover, h. pylori actively searches for an optimal microniche within a stomach, and it has been shown that not every microniche equal ... | 2017 | 28124150 |
| correction: the o-antigen flippase wzk can substitute for murj in peptidoglycan synthesis in helicobacter pylori and escherichia coli. | [this corrects the article doi: 10.1371/journal.pone.0161587.]. | 2017 | 28114371 |
| identification of helicobacter pylori and the evolution of an efficacious childhood vaccine to protect against gastritis and peptic ulcer disease. | establishment of helicobacter pylori infection as an etiologic agent of peptic ulcer disease and other gastric pathologies marked a revolution in gastroenterology which spurred an enormous interest in gastric physiology and immunology research. the association was soon also demonstrated in children as well. application of antimicrobial therapies have proven remarkably efficacious in eradicating h. pylori and curing pediatric patients of duodenal ulcers as well as gastritis, negating a lifetime o ... | 2017 | 27701380 |
| induction of mucosal immune responses against helicobacter pylori infection after sublingual and intragastric route of immunization. | there is a current lack of effective mucosal vaccines against major gastroenteric pathogens and particularly against helicobacter pylori, which causes a chronic infection that can lead to peptic ulcers and gastric cancer in a subpopulation of infected individuals. mucosal cd4(+) t-cell responses have been shown to be essential for vaccine-induced protection against h. pylori infection. the current study addresses the influence of the adjuvant and site of mucosal immunization on early cd4(+) t-ce ... | 2017 | 27676456 |
| cag-delta (cag3) protein from the helicobacter pylori 26695 cag type iv secretion system forms ring-like supramolecular assemblies. | helicobacter pylori is an important cause of gastric pathologies and persistent infection can lead to stomach cancer. virulent h. pylori strains encode a type iv secretion system responsible for translocation of the oncogenic caga protein into cells of the gastric mucosa. gene hp0522 encodes the essential component cagδ (cag3), and we show by gel filtration and cross-linking that purified cagδ forms high molecular mass complexes. in contrast, its interaction partner cagt is mostly monomeric, but ... | 2017 | 27986823 |
| a cheap, simple high throughput method for screening native helicobacter pylori urease inhibitors using a recombinant escherichia coli, its validation and demonstration of pistacia atlantica methanolic extract effectivity and specificity. | helicobacter pylori is the most frequent and persistent bacterial infection worldwide, and a risk factor for active gastritis, peptic ulcers, mucosa-associated lymphoid tissue lymphoma, and gastric cancer. although combined antibiotics treatment is effective cases of antibiotic resistance are reported at an alarming rate. the h. pylori urease enzyme is essential for the bacteria establishment in the gastric mucosa, resulting urease inhibitors being sought after as effective and specific anti- h. ... | 2017 | 27923651 |
| [preparation of polyclonal antibody against recombinant sigma(54) protein from helicobacter pylori]. | objective to express and purify recombinant sigma(54) protein of helicobacter pylori, and prepare polyclonal antibody against sigma(54) protein. methods intact rpon gene fragment was amplified from helicobacter pylori (h. pylori) 26695 genome, and then cloned into prokaryotic expression vector ptriex(tm)-4 with (6)his coding sequence. the recombinant plasmid was transformed into e.coli jm109de. the recombinant protein with 6-his tag was expressed by iptg induction and purified by his-bind affini ... | 2017 | 28031123 |
| randomized clinical trial: esomeprazole, bismuth, levofloxacin, and amoxicillin or cefuroxime as first-line eradication regimens for helicobacter pylori infection. | the eradication of helicobacter pylori infection remains a challenge, especially in the patients unsuitable to take penicillin. cephalosporin has the potential to replace amoxicillin for h. pylori eradication. | 2017 | 28391418 |
| helicobacter pylori genotypes determine risk of non-cardia gastric cancer and intestinal- or diffuse-type gc in ardabil: a very high-risk area in northwestern iran. | frequency of the helicobacter pylori vaca gene polymorphism and its association with gastric cancer (gc) was assessed in ardabil, a very high-risk area in northwestern iran. we determined the presence of the h. pylori 16s rdna gene and the vaca s-, m-, i-, and d-region genotypes in dna from fresh gastric biopsies. patients with gc were classified based on both the anatomic site and the histopathologic type of tumor of 135 patients, including 57 with non-atrophic gastritis (nag) and 78 with gc, 1 ... | 2017 | 28390977 |
| helicobacter pylori infection increases the risk of adult-onset asthma: a nationwide cohort study. | helicobacter pylori infection (hpi) appears to reduce risk of childhood-onset asthma, but the relationship between hpi and adult-onset asthma is inconclusive. this study explored the potential association between hpi and risk of adult-onset asthma. we conducted a national insurance retrospective cohort study using the longitudinal health insurance database (lhid 2000) in taiwan. we enrolled the hpi group consisting of 1664 patients with hpi diagnosis between 2000 and 2007, and the non-hpi group ... | 2017 | 28389738 |
| analysis of the associations among helicobacter pylori infection, adiponectin, leptin, and 10-year fracture risk using the fracture risk assessment tool: a cross-sectional community-based study. | helicobacter pylori (h. pylori) infection may induce inflammatory cytokines or adipokines that influence bone turnover and bone fracture risk. this study aimed to evaluate the association among h. pylori infection, adipokines, and 10-year fracture risk using the fracture risk assessment tool scale. from august 2013 to february 2016, a community-based cohort was surveyed by keelung chang-gung memorial hospital. subjects were included if they were older than 40 years and not pregnant. all particip ... | 2017 | 28388631 |
| treating helicobacter pylori effectively while minimizing misuse of antibiotics. | experts now recommend that all helicobacter pylori infections be eradicated unless there are compelling reasons not to. as with other infectious diseases, effective therapy should be based on susceptibility. | 2017 | 28388387 |
| approach, attitudes, and knowledge of general practitioners in relation to helicobacter pylori is inadequate. there is much room for improvement! | helicobacter pylori (hp) infection is one of the most common infections in humans. due to its worldwide prevalence, a series of guidelines and recommendations has been developed for the appropriate screening, diagnosis, and management of patients with hp infection. | 2017 | 28385468 |
| dissimilar pain of primary epiploic appendagitis and malabsorption. | primary epiploic appendagitis (pea) is a rare cause of acute or subacute abdominal complaints and non-migratory pain. usually the diagnosis of pea is made when computed tomography (ct) reveals characteristic figures. nonspecific abdominal complaints including diffuse abdominal pain may be caused by carbohydrate and/or protein malabsorption. we report a case of a patient with pea who recovered without medication or surgical treatment within a few days. eight months later, he was diagnosed with la ... | 2017 | 28384920 |
| association of the il-1rn variable number of tandem repeat polymorphism and helicobacter pylori infection: a meta-analysis. | the aim of this study was to clarify the association of il-1rn variable number of tandem repeat (vntr) polymorphism and h. pylori infection. we performed a meta-analysis of studies retrieved by systematic searches of pubmed, embase and the cochrane library. data were analyzed with stata 13.1 using pooled odds ratios (ors) with 95% confidence intervals (cis). a total of 18 studies were included in our meta-analysis, and il-1rn vntr was found to be significantly associated with h. pylori infection ... | 2017 | 28384207 |
| esophageal squamous papilloma in a pediatric patient with helicobacter pylori gastritis. | 2017 | 28382843 | |
| association of helicobacter pylori and crohn's disease incidence: an inversion reaction? | 2017 | 28382482 | |
| a cohort study on helicobacter pylori infection associated with nonalcoholic fatty liver disease. | previous studies have suggested a link between helicobacter pylori (h. pylori) infection and nonalcoholic fatty liver disease (nafld), yet large-scale longitudinal studies are lacking to elucidate this association. | 2017 | 28382402 |
| differential microrna expression between gastric cancer tissue and non-cancerous gastric mucosa according to helicobacter pylori status. | micrornas (mirnas) are key post-translational mechanisms which can regulate gene expression in gastric carcinogenesis. to identify mirnas responsible for gastric carcinogenesis, we compared expression levels of mirnas between gastric cancer tissue and non-cancerous gastric mucosa according to helicobacter pylori status. | 2017 | 28382284 |
| the role of environmental tobacco exposure and helicobacter pylori infection in the risk of chronic tonsillitis in children. | helicobacter pylori (h. pylori) is a chronic infectious pathogen with high prevalence. this study investigated the interaction between environmental tobacco exposure and h. pylori infection on the incidence of chronic tonsillitis in chinese children. | 2017 | 28380174 |
| protein tunnels: the case of urease accessory proteins. | transition metals are both essential micronutrients and limited in environmental availability. the ni(ii)-dependent urease protein, the most efficient enzyme known to date, is a paradigm for studying the strategies that cells use to handle an essential, yet toxic, metal ion. urease is a virulence factor of several human pathogens, in addition to decreasing the efficiency of soil organic nitrogen fertilization. ni(ii) insertion in the urease active site is performed through the action of three es ... | 2017 | 28379694 |
| link between serum pepsinogen concentrations and upper gastrointestinal endoscopic findings. | the serum pepsinogen (pg) assay findings are correlated with the status of helicobacter pylori infection, but there are controversies on the link with upper gastrointestinal (ugi) endoscopic findings. the aim of this study was to determine the significance of a serum pg assay for correlating with endoscopic findings in h. pylori-seroprevalent adult population. korean adults who visited for a health check-up were included consecutively. subjects after gastrectomy or h. pylori eradication were exc ... | 2017 | 28378553 |
| a link between platelet to lymphocyte ratio and helicobacter pylori infection. | chronic helicobacter pylori gastritis affects two-thirds of the world's population and is one of the most common chronic inflammatory disorders of humans, the infection clearly results in chronic mucosal inflammation in the stomach and duodenum, which, in turn, might lead to abnormalities in gastroduodenal motility and sensitivity and is the most frequent cause of dyspepsia and peptic disease. some studies showed that there was a correlation between low-grade inflammation as crp and hp infection ... | 2017 | 28374931 |
| effect of treatment failure on the caga epiya motif in helicobacter pylori strains from colombian subjects. | to evaluate effect of treatment failure on caga and vaca genotypes in helicobacter pylori (h. pylori) isolates from colombia. | 2017 | 28373764 |
| gastrointestinal bleeding in patients on novel oral anticoagulants: risk, prevention and management. | novel oral anticoagulants (noacs), which include direct thrombin inhibitor (dabigatran) and direct factor xa inhibitors (rivaroxaban, apixaban and edoxaban), are gaining popularity in the prevention of embolic stroke in non-valvular atrial fibrillation as well as in the prevention and treatment of venous thromboembolism. however, similar to traditional anticoagulants, noacs have the side effects of bleeding, including gastrointestinal bleeding (gib). results from both randomized clinical trials ... | 2017 | 28373761 |
| rapid urine antibody test for helicobacter pylori infection in adolescents. | helicobacter pylori infection is associated with gastric cancer; thus, early diagnosis and treatment are crucial. since h. pylori infection in adolescents or young adults shows few symptoms, screening tests are necessary for this population. in this study, the accuracy of the rapid urine-h. pylori antibody (u-hpab) test was evaluated and compared to that of urine and serum h. pylori enzyme-linked immunosorbent assays (u-hpelisa and s-hpelisa, respectively) in junior high school students. | 2017 | 28371166 |
| serum gastrin and cholecystokinin are associated with subsequent development of gastric cancer in a prospective cohort of finnish smokers. | gastrin, which induces gastric acid secretion, and a structurally similar hormone, cholecystokinin (cck)-a potent acid inhibitor, may each play a role in gastric cancer. however, few studies have investigated this hypothesis in humans. we therefore investigated whether serum gastrin or cck concentrations at baseline were associated with the incidence of gastric non-cardia adenocarcinomas (gnca), oesophagogastric junctional adenocarcinomas (egja) or gastric carcinoid tumours over 24 years of foll ... | 2017 | 28369403 |
| genetic polymorphisms in tlr1, tlr2, tlr4, and tlr10 of helicobacter pylori-associated gastritis: a prospective cross-sectional study in thailand. | the toll-like receptors (tlrs) mediate the recognition of helicobacter pylori and initiate the innate immune response to infection. we hypothesized those genetic polymorphisms in the tlr1, tlr2, tlr4, and tlr10 influence bacterial infection, affecting susceptibility h. pylori to disease outcomes. genomic dna was extracted and genotypes of tlr1 (rs4833095), tlr2 (rs3804099 and rs3804100), tlr4 (rs10759932), and tlr10 (rs10004195) polymorphism were detected by the tagman single-nucleotide epolymor ... | 2017 | 28368946 |
| crystallization and x-ray analysis of the extracellular adhesion domain of helicobacter pylori adhesin a: the significance of the cation composition in the crystallization precipitant. | adherence to host cells is a crucial step in the process of bacterial infection, which is usually mediated by a number of outer membrane proteins identified as adhesins. helicobacter pylori adhesin a (hpaa) is a member of the adhesin family that mediates the adherence of helicobacter pylori to gastric epithelial cells, and consequently assists the bacteria in becoming a life-long colonizer of the human stomach. in this study, two constructs were made for the production of truncated hpaa proteins ... | 2017 | 28368278 |
| association of genetic polymorphisms in the lncrnas with gastric cancer risk in a chinese population. | background: genome-wide association studies have identified that polymorphisms in 8q24 confer susceptibility to gastric cancer. polymorphisms in the lncrna prncr1, pcat1, and ccat2 transcribed from the 8q24 locus have a potential risk for gastric cancer. methods: to evaluate whether there is such an association in chinese population, a case-control study enrolled 494 patients and 494 healthy controls was carried out. sequenom massarray platform was used for genotyping. results: this study showed ... | 2017 | 28367233 |
| helicobacter pylori-associated upper gastrointestinal symptoms: fd or hpd? | 2017 | 28365919 | |
| [effect of telephone follow-up on compliance and helicobacter pylori eradication in patients with helicobacter pylori infection]. | to evaluate effect of telephone follow-up combined with written instruction on compliance and helicobacter pylori (h. pylori) eradication in patients with h. pylori infection. methods: a total of 160 h. pylori positive patients were randomly divided into an experimental group and a control group (n=80 in each group). all the patients got the guide instruction named "the guidance of clinical medication for h. pylori infection patients" before the treatment. the patients in the experimental group ... | 2017 | 28364105 |
| visualization of consensus genome structure without using a reference genome. | standard graphical tools for whole genome comparison require a reference genome. however, any reference is also subject to annotation biases and rearrangements, and may not serve as the standard except for those of extensively studied model species. to fully exploit the rapidly accumulating sequence data from the recent sequencing technologies, genome comparison without any reference has been anticipated. | 2017 | 28361716 |
| functional disruption of peroxiredoxin by bismuth antiulcer drugs attenuates helicobacter pylori survival. | bismuth drugs have been used clinically to treat infections from helicobacter pylori, a pathogen that is strongly related to gastrointestinal diseases even stomach cancer. despite extensive studies, the mechanisms of action of bismuth drugs are not fully understood. alkyl hydroperoxide reductase subunit c (ahpc) is the most abundant 2-cysteine peroxiredoxin, crucial for h. pylori survival in the host by defense of oxidative stress. herein we show that a bi(iii) antiulcer drug (cbs) binds to the ... | 2017 | 28361362 |
| cot kinase plays a critical role in helicobacter pylori-induced il-8 expression. | helicobacter pylori is a major pathogen causing various gastric diseases including gastric cancer. infection of h. pylori induces pro-inflammatory cytokine il-8 expression in gastric epithelial cells in the initial inflammatory process. it has been known that h. pylori can modulate ras-raf-mek-erk signal pathway for il-8 induction. recently, it has been shown that another signal molecule, cancer osaka thyroid oncogene/tumor progression locus 2 (cot/tpl2) kinase, activates mek and erk and plays a ... | 2017 | 28361341 |
| efficacy and safety of quinolone-containing rescue therapies after the failure of non-bismuth quadruple treatments for helicobacter pylori eradication: systematic review and meta-analysis. | anti-helicobacter pylori eradication treatment fails in a significant percentage of cases. although this percentage has been reduced to 5-15% with the use of non-bismuth quadruple therapies, limited data exist regarding rescue after failure of these treatments. | 2017 | 28361211 |
| from inflammation to gastric cancer: role of helicobacter pylori. | gastric cancer is a multifactorial disease and a leading cause of mortality and the risk factors for this include environmental factors and factors that influence host-pathogen interaction and complex interplay between these factors. gastric adenocarcinomas are of two types, namely intestinal and diffuse type, and helicobacter pylori (h. pylori) infection has been suspected of being causally linked to the initiation of chronic active gastritis, which leads to adenocarcinoma of the intestinal typ ... | 2017 | 28356927 |
| helicobacter pylori infection in icelandic children. | the prevalence of helicobacter pylori (hp) infection is decreasing in the western world. the seroprevalence among 25-50-year-old icelandic adults was recently shown to be 30-40%. information on the seroprevalence in nordic children is limited. we aimed at ascertaining the infection prevalence among healthy icelandic children. | 2017 | 28355955 |
| cutoff pepsinogen level for predicting unintendedly eradicated cases of helicobacter pylori infection in subjects with seemingly normal pepsinogen levels. | in the abc method, which is a method for risk stratification of gastric cancer using serum anti-helicobacter pylori antibody and pepsinogen (pg) test, subjects with normal pg and seronegative for h. pylori are named as "group a" and are regarded as having a low risk of gastric cancer. these "group a" subjects include unintentionally eradicated cases at relatively high risk, and this study aimed to identify these subjects. | 2017 | 28355604 |
| arginase of helicobacter gastric pathogens uses a unique set of non-catalytic residues for catalysis. | helicobacter pylori arginase, a bimetallic enzyme, is crucial for pathogenesis of the bacterium in human stomach. despite conservation of the signature motifs in all arginases, the h. pylori homolog has a non-conserved motif ((153)eseekawqklcsl(165)), whose role was recently shown to be critical for its stability and function. the sequence analysis also reveals the presence of this motif with critical residues in the homolog of other helicobacter gastric pathogens. however, the underlying mechan ... | 2017 | 28355540 |
| helicobacter pylory infection in patients with esophageal squamous cell carcinoma. | esophageal squamous cell carcinoma is one of the most common esophageal diseases in the developing world, but the relationship between esophageal squamous cell carcinoma and helicobacter pylori infection remains a neglected topic. the primary objective of this study was to determine the association between helicobacter pylori infection and esophageal squamous cell carcinoma. a second purpose was to determine the incidence and factors associated with helicobacter pylori infection following esopha ... | 2017 | 28355360 |
| helicobacter pylori infection and low dietary iron alter behavior, induce iron deficiency anemia, and modulate hippocampal gene expression in female c57bl/6 mice. | helicobacter pylori (h.pylori), a bacterial pathogen, is a causative agent of gastritis and peptic ulcer disease and is a strong risk factor for development of gastric cancer. environmental conditions, such as poor dietary iron resulting in iron deficiency anemia (ida), enhance h.pylori virulence and increases risk for gastric cancer. ida affects billions of people worldwide, and there is considerable overlap between regions of high ida and high h.pylori prevalence. the primary aims of our study ... | 2017 | 28355210 |
| the effect of mdr1 c3435t polymorphism on the eradication rate of h. pylori infection in ppi-based triple therapy: a meta-analysis. | several studies have reported that multidrug resistance gene 1 (mdr1) c3435t polymorphism was associated with the rate of helicobacter pylori (h. pylori) eradication in proton pump inhibitor (ppi)-based triple therapy. however, the conclusions were inconsistent. therefore, this meta-analysis was conducted to evaluate the impact of mdr1 c3435t polymorphism on h. pylori eradication by ppi-based triple therapy. | 2017 | 28353592 |
| association between helicobacter pylori infection and angiographically demonstrated coronary artery disease: a meta-analysis. | coronary artery disease (cad) is a leading cause of mortality globally. however, the etiology and pathogenesis of cad are not fully understood. the aim of the present meta-analysis was to estimate the association between the risk of cad and helicobacter pylori (h. pylori) infection. a literature search was performed to identify eligible studies published prior to august 14, 2014. fixed or random effect meta-analytical methods were used to pool the data and perform the subgroup analyses. the effe ... | 2017 | 28352367 |
| acid-suppressing therapies and subsite-specific risk of stomach cancer. | associations of stomach cancer risk with histamine type-2 receptor antagonists (h2ra) and proton-pump inhibitors (ppi) are controversial. we hypothesised that proximal extension of helicobacter pylori infection from acid suppression would disproportionately increase cancers at proximal subsites. | 2017 | 28350791 |
| the irish helicobacter pylori working group consensus for the diagnosis and treatment of h. pylori infection in adult patients in ireland. | irish eradication rates for helicobacter pylori are decreasing and there is an increase in the prevalence of antibiotic-resistant bacteria. these trends call into question current management strategies. | 2017 | 28350745 |
| nf-κb signaling in gastric cancer. | gastric cancer is a leading cause of cancer death worldwide. diet, obesity, smoking and chronic infections, especially with helicobacter pylori, contribute to stomach cancer development. h. pylori possesses a variety of virulence factors including encoded factors from the cytotoxin-associated gene pathogenicity island (cagpai) or vacuolating cytotoxin a (vaca). most of the cagpai-encoded products form a type 4 secretion system (t4ss), a pilus-like macromolecular transporter, which translocates c ... | 2017 | 28350359 |
| vonoprazan-based regimen is more useful than ppi-based one as a first-line helicobacter pylori eradication: a randomized controlled trial. | background. a new agent, potassium-competitive acid blocker vonoprazan (vpz) has potent acid-inhibitory effects and may offer advantages over conventional h. pylori eradication therapies. we aimed to compare the eradication rate between vpz-based treatment and ppi-based one. methods. this randomized controlled trial was designed to assign 141 patients with h. pylori-positive gastritis to vpz group (vpz 20 mg, amoxicillin 750 mg, and clarithromycin 200 or 400 mg twice daily for 7 days) or ppi gro ... | 2017 | 28349044 |
| using stable isotope techniques in nutrition assessments and tracking of global targets post-2015. | stable isotopes are non-radioactive, safe and are applied for various purposes in human health assessment in trace amounts that minimally disturb normal physiology. the international atomic energy agency supports the use of stable isotope techniques to design and evaluate interventions addressing malnutrition in all its forms with focus on infant and young child feeding; maternal and adolescent nutrition; diet quality; prevention and control of non-communicable diseases; healthy ageing and gut f ... | 2017 | 28347373 |
| the relationship between the helicobacter pylori seropositivity with systemic and local oxidative status and hyperemesis gravidarum: a pilot study. | the aim of study was to determine the helicobacter pylori seropositivity and oxidative parameters in serum and saliva of pregnant women with poor oral hygiene and hyperemesis gravidarum (hg). | 2017 | 28347201 |
| helicobacter pylori infection detection from gastric x-ray images based on feature fusion and decision fusion. | in this paper, a fully automatic method for detection of helicobacter pylori (h. pylori) infection is presented with the aim of constructing a computer-aided diagnosis (cad) system. in order to realize a cad system with good performance for detection of h. pylori infection, we focus on the following characteristic of stomach x-ray examination. the accuracy of x-ray examination differs depending on the symptom of h. pylori infection that is focused on and the position from which x-ray images are ... | 2017 | 28346875 |
| fluorogenic templated reaction cascades for rna detection. | nucleic acids detection is essential to the study of biological processes and to diagnosis of pathological states. although pcr is highly effective in vitro, methods that can function without prior sample preparation, thermal cycling, or enzymes are of interest due to their simplicity. most current non-pcr detection methods rely on linear signal amplification, which hinders the detection of small amounts of genetic material. to address this limitation, we tested a new strategy for attaining high ... | 2017 | 28345912 |
| high fluoroquinolone resistant strains of helicobacter pylori in the golden triangle | background and aims: helicobacter pylori (h. pylori) infections, associated with fatal gi diseases such as gastric cancer and malt lymphoma, remain a major health problem in asean countries. the golden triangle has long been known as one of asia’s main opium-producing areas. there have been no prior studies of h. pylori infection in this area. the major objectives of this project were therefore to establish prevalence, antibiotic resistance patterns and associated predictive in the golden triang ... | 2017 | 28345829 |
| a prospective evaluation of levofloxacin based triple therapy for refractory helicobacter pylori infection in australia. | first line helicobacter pylori eradication failure is a common and challenging problem. | 2017 | 28345276 |
| clarithromycin resistance in helicobacter pylori and its molecular determinants in northern spain, 2013-2015. | clarithromycin resistance (clr-r) is the main reason for failure of helicobacter pylori infection treatment, which is frequently empirically prescribed due to the erroneous belief that culture for susceptibility testing is difficult. the aim of this study was to determine clr-r in a region of southern europe and to evaluate the utility of a pcr sequencing assay applied on gastroduodenal biopsies in detecting h. pylori and clarithromycin (clr) susceptibility. | 2017 | 28343971 |
| gastric outlet obstruction: an unusual case of primary duodenal tuberculosis. | tuberculosis is a major health problem worldwide. gastrointestinal tuberculosis presenting as isolated involvement of the duodenum is a rare case. | 2017 | 28343151 |
| high salt intake is associated with atrophic gastritis with intestinal metaplasia. | although several studies have investigated excessive salt intake as a risk factor for gastric precancerous lesions such as atrophic gastritis (ag) and intestinal metaplasia (im), the evidence is insufficient to make conclusion. we evaluated the association between gastric precancerous lesions and salt intake. | 2017 | 28341758 |
| overexpression of tim-3 reduces helicobacter pylori-associated inflammation through tlr4/nfκb signaling in vitro. | the present study aimed to investigate the interaction between t-cell immunoglobulin and mucin-domain-containing molecule-3 (tim-3) and toll-like receptor 4 (tlr4)/nuclear factor κb (nf‑κb) signaling in helicobacter pylori-infected raw264.7 macrophage cells. raw264.7 cells were co‑cultured with h. pylori ss1 at different bacteria/cell ratios, and subsequently the mrna expression of tim‑3, tlr4, and myeloid differentiation factor 88 (myd88) was measured by reverse transcription-quantitative polym ... | 2017 | 28339054 |
| type iv secretion and signal transduction of helicobacter pylori caga through interactions with host cell receptors. | helicobacter pylori is a highly successful human bacterium, which is exceptionally equipped to persistently inhabit the human stomach. colonization by this pathogen is associated with gastric disorders ranging from chronic gastritis and peptic ulcers to cancer. highly virulent h. pylori strains express the well-established adhesins baba/b, saba, alpa/b, oipa, and hopq, and a type iv secretion system (t4ss) encoded by the cag pathogenicity island (pai). the adhesins ascertain intimate bacterial c ... | 2017 | 28338646 |
| helicobacter pylori in periodontal pockets and saliva: a possible role in gastric infection relapses. | it has been a long time since the scientific community started to speculate upon the presence of helicobacter pylori (hp) in periodontal pockets as an extra-gastric reservoir responsible for gastric relapses after eradication therapy. the aim of this study is to evaluate the presence of oral hp in a group of patients who underwent examination for gastric infection. sixty patients were enrolled in the current study, subdivided into two groups: 30 patients with a positive result for hp gastric inf ... | 2017 | 28337902 |
| helicobacter pylori and barretts esophagus: a protective factor or a real cause? | notwithstanding the definite aetiopathogenetic path of certain diseases, the relationship between helicobacter pylori (h. pylori) and barretts esophagus (be), a condition that increases the risk for dysplasia and consequently adenocarcinoma of the distal esophagus and esophagogastric junction, remains uncertain. this paper reviews the current scientific literature with emphasis on the protective correlation between h. pylori infection and be and demonstrates that a causal relationship has not b ... | 2017 | 28337865 |
| relationship between helicobacter pylori infection and celiac disease: a cross-sectional study and a brief review of the literature. | whether helicobacter pylori triggers celiac disease (cd) or protects against cd is currently the subject of research. in the literature, there are epidemiologic studies that have reported conflicting results regarding the association between h. pylori and cd. | 2017 | 28337237 |
| cost-effectiveness analysis of helicobacter pylori diagnostic methods in patients with atrophic gastritis. | background. there are several diagnostic methods for helicobacter pylori (h. pylori) infection. a cost-effective analysis is needed to decide on the optimal diagnostic method. the aim of this study was to determine a cost-effective diagnostic method in patients with atrophic gastritis (ag). methods. a decision-analysis model including seven diagnostic methods was constructed for patients with ag diagnosed by esophagogastroduodenoscopy. expected values of cost and effectiveness were calculated fo ... | 2017 | 28337217 |
| antibiotic resistance among helicobacter pylori clinical isolates in lima, peru. | gastric carcinoma is the most common cancer and cause of cancer mortality in peru. helicobacter pylori, a bacterium that colonizes the human stomach, is a group 1 carcinogen due to its causal relationship to gastric carcinoma. while eradication of h. pylori can help prevent gastric cancer, characterizing regional antibiotic resistance patterns is necessary to determine targeted treatment for each region. thus, we examined primary antibiotic resistance in clinical isolates of h. pylori in lima, p ... | 2017 | 28331349 |
| genotype association gstm1 null and gastric cancer: evidence-based meta-analysis. | gastric cancer is the fourth most common cancer in men and the sixth among women, except for non-melanoma skin tumors, in brazil. epidemiological evidences reveal the multifactorial etiology of this cancer, highlighting risk factors such as: infection by the bacterium helicobacter pylori, advanced age, smoking, chronic alcohol abuse, eating habits and genetic polymorphisms. considering the context of genetic polymorphisms, there is the absence of the gstm1 gene. the lack of gstm1 function to det ... | 2017 | 28327825 |
| the investigation of helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints. | the oral cavity can be an extra-gastric reservoir for helicobacter pylori (h.pylori). this can play a role in the pathogenesis of halitosis, glossitis, recurrent aphthous stomatitis, and dental caries. the present study was conducted to detect the presence of h.pylori within the dental biofilm and in saliva samples collected from children suffering from dyspepsia and children without any gastrointestinal complaints. associations with gastric infection, halitosis, and some oral parameters were al ... | 2017 | 28327128 |
| the corpus-predominant gastritis index can be an early and reversible marker to identify the gastric cancer risk of helicobacter pylori-infected nonulcer dyspepsia. | corpus-predominant gastritis index (cgi) is an early histological marker to identify helicobacter pylori-infected gastric cancer relatives at risk of cancer. this study validated whether cgi is more prevalent in h. pylori-infected nonulcer dyspepsia (nud) subjects than in duodenal ulcer (du) controls and whether it is reversible after h. pylori eradication or is correlated with noninvasive biomarkers. | 2017 | 28326664 |
| multimodality treatment of gastric lymphoma. | gastric lymphoma is rare, accounting for 3% of gastric neoplasms and 10% of lymphomas. treatment should be stratified based on histologic type, stage, helicobacter pylori infection, and t(11;18) translocation status. surgery is no longer a mainstay for treatment and should be reserved for rare situations such as perforation, fistula formation, and severe bleeding. multimodal treatment, including h pylori eradication, radiation therapy, chemotherapy, and immunotherapy, should be provided as appro ... | 2017 | 28325194 |
| helicobacter pylori eradication in the swedish population. | helicobacter pylori is associated with peptic ulcers and gastric cancer and its eradication aims to prevent these conditions. the recommended eradication regimen is triple therapy, consisting of a proton-pump inhibitor in combination with clarithromycin and amoxicillin or metronidazole for 7 days. yet, other antibiotic regimens are sometimes prescribed. we aimed to assess the use of eradication therapy for h. pylori in the swedish population during the last decade. | 2017 | 28323552 |