Publications

coronaviruses associated with the superfamily musteloidea.	among the animal superfamily musteloidea, which includes those commonly known as mustelids, naturally occurring and species-specific alphacoronavirus infections have been observed in both mink (mustela vison/neovison vison) and domestic ferrets (mustela putorius furo). ferret systemic coronavirus (frscv), in particular, has been associated with a rare but fatal systemic disease. in recent months, it has become apparent that both minks and ferrets are susceptible to severe acute respiratory syndr ...	2021	33468694
persistent infection and pancytopenia associated with ferret systemic coronaviral disease in a domestic ferret.	ferret systemic coronaviral disease (fscd) is a well-established cause of mortality in domestic ferrets. we describe herein novel findings in a case of fscd that was diagnosed and medically managed following virus detection by immunohistochemical (ihc) staining of surgical biopsy samples. hematologic changes in this ferret suggested spread of the virus to the bone marrow, which was confirmed by ihc staining of a postmortem sample. genotyping of the virus indicated that the virus grouped with alp ...	2020	32589111
protease inhibitors broadly effective against feline, ferret and mink coronaviruses.	ferret and mink coronaviruses typically cause catarrhal diarrhea in ferrets and minks, respectively. in recent years, however, systemic fatal coronavirus infection has emerged in ferrets, which resembles feline infectious peritonitis (fip) in cats. fip is a highly fatal systemic disease caused by a virulent feline coronavirus infection in cats. despite the importance of coronavirus infections in these animals, there are no effective commercial vaccines or antiviral drugs available for these infe ...	2018	30342822
detection of novel ferret coronaviruses and evidence of recombination among ferret coronaviruses.	in an epidemiological study of ferret coronaviruses (frcovs), novel frcov strains (saitama-1 and aichi-1) were detected by reverse transcription-polymerase chain reaction (rt-pcr) and nucleotide sequence analysis of partial rna-dependent rna polymerase (rdrp) genes. phylogenetic analysis indicated that these strains belonged to different clusters from other frcov strains. next, the nucleotide sequence of the 3'-terminal region of saitama-1 (8271 bases) strain was determined and compared with tho ...	2016	27369429
establishment of serological test to detect antibody against ferret coronavirus.	since there is no available serological methods to detect antibodies to ferret coronavirus (frcov), an enzyme-linked immunosorbent assay (elisa) using recombinant partial nucleocapsid (n) proteins of the ferret coronavirus (frcov) yamaguchi-1 strain was developed to establish a serological method for detection of frcov infection. many serum samples collected from ferrets recognized both a.a. 1-179 and a.a. 180-374 of the n protein, but two serum samples did not a.a. 180-374 of the n protein. thi ...	2016	26935842
ferret coronavirus-associated diseases.	a novel coronavirus of ferrets was first described in 1993. this coronavirus caused an enteric disease called epizootic catarrhal enteritis (ece). recently, a ferret systemic coronavirus (frscv)-associated disease was discovered. this new systemic disease resembles the dry form of feline infectious peritonitis (fip) and has been reported in the united states and europe. this article addresses the clinical signs, pathology, pathogenesis, diagnosis, treatment, and prevention of this ferret fip-lik ...	2010	20682435
comparative sequence analysis of the distal one-third of the genomes of a systemic and an enteric ferret coronavirus.	ferret systemic coronavirus (frscv) infection is associated with an emerging, highly fatal disease of ferrets. enhanced macrophage tropism and the resulting induction of pyogranulomatous lesions are shared with feline infectious peritonitis virus (fipv) infection in cats, but are not features of ferret enteric coronavirus (frecv) infection. comparative sequence analysis of the distal one-third of the genomes of one frscv and one frecv strain showed that these two ferret coronaviruses share >96% ...	2010	20079778