Publications

changing seroprevalence of varicella zoster virus infection in a tropical city state, singapore.	to understand the seroepidemiology of varicella zoster virus (vzv) in the singaporean population, based on a paediatric survey conducted in 2008-2010 and the 2010 national health survey. the findings were compared with previous studies carried out in 1989-1990, 1993, 1998, and 2004.	2014	24269652
seroepidemiology of varicella and the reliability of a self-reported history of varicella infection in singapore military recruits.	varicella is an acute disease with significant morbidity. however, there is little knowledge on the seroepidemiology of the disease in singapore. the objective of this study was to assess the seroprevalence of varicella zoster virus (vzv) antibodies in military recruits in singapore and to ascertain the predictive value of a self-reported history of varicella. the latter is a possible proxy for seroprevalence, and may be used to provide efficient identification of candidates for vaccination.	2007	17767333
varicella screening and vaccination for healthcare workers at kk women's and children's hospital.	varicella is a highly contagious disease with significant morbidity and mortality, especially in adults. it can lead to nosocomial transmission with dire consequences, especially in a healthcare facility where children and pregnant women form the majority of patients. at kk women's and children's hospital, we embarked on a programme in 2 phases, between 1997 and 1999, to screen healthcare workers (hcws) for varicella immunity and to offer varicella vaccination to those who tested negative for an ...	2004	15098642
amplification and sequencing of varicella-zoster virus (vzv) gene 4: point mutation in a vzv strain causing chickenpox during pregnancy.	the varicella-zoster virus (vzv) causes chickenpox (varicella) as the primary disease and shingles (zoster) as a recurrent manifestation of infection, both being generally benign and self-limiting. while these infections may be severe in adults and even life-threatening in immunosuppressed individuals, they may be amenable to effective antiviral drugs or varicella-zoster immune globulin, provided the treatment is administered early. the prompt diagnosis of vzv infections may be accelerated by ra ...	1997	9607081
comparative analysis of the restriction endonuclease profiles of the dumas and singapore strains of varicella-zoster virus.	the incidence of varicella in singapore has been increasing since 1984. in 1991, 17,930 cases were reported in a population of about 3 million. a serological survey completed in 1990 demonstrated that only 43% of the cohort had antibodies to varicella-zoster virus (vzv), indicating inadequate herd immunity. to exclude novel vzv strains, representative vzv isolates from 9 chicken pox and 4 zoster patients were characterised by restriction endonuclease analysis. dnas were extracted from viral isol ...	1993	8228928
prevalence of varicella-zoster virus infection in singapore.	the incidence of chickenpox in singapore has been increasing since 1984. a seroepidemiological survey was conducted in 1989-90 to determine the prevalence of varicella-zoster virus-specific igg antibody in the healthy population in singapore aged from 6 months to over 45 years. overall, 42.8% of 500 samples assayed qualitatively by the elisa method were positive, with less than one fifth of those aged under 15 years and less than half of the 15-24 year olds possessing antibody to the virus. howe ...	1992	1523475