Publications

[newly detected relationships between antibacterial activity and structure of some chalocones].		1976	130785
the separation and reactivity in vitro of a subpopulation of human lymphocytes which bind histamine. correlation of histamine reactivity with cellular maturation.		1976	132992
the effect of increased brain gaba produced by amino-oxyacetic acid on arousal in rats.	previous work has reported behavioral arousal in the rat to be inversely related to cortical gaba production. therefore the effects of an increase in brain gaba levels, induced by amino-oxyacetic acid, on measures of behavioural arousal such as rearing and ambulation were examined. the increase in gaba was immediately associated with decreased rearing, however the behaviour was later indistinguishable from control values while the levels of brain gaba remained raised. it was suggested that the r ...	1976	134388
effects of exercise training and exhaustion on 45ca uptake by rat skeletal muscle mitochondria and sarcoplasmic reticulum.	mitochondrial and sarcoplasmic reticular 45ca2+ uptake and ca2+-atpase activity were determined in skeletal muscle from exercise trained and non-trained rats at rest or following short-term exhaustive exercise. in trained rats exercised to exhaustion, mitochondrial 45ca2+ uptake was significantly depressed when compared to non-trained rats at rest. ca2+-atpase activity of sarcoplasmic reticulum from trained rats exercised to exhaustion was significantly increased as compared to trained rats at r ...	1976	134437
[synchronous electric activity with inspiration in the vastus lateralis muscle of the anesthesied dog breathing spontaneously].	in the dog, under chloralose or pentobarbitone anesthesia and breathing spontaneously, a muscular electrical activity of low voltage synchronous with respiration was observed in m. vastus lateralis. the mean maximum amplitude of this activity is inversely linked with respiratory rate. when the respiratory frequency is equal or exceeds 25 cycles per minute this activity disappears. such a phenomenon seems to be related to the activity of the respiratory centre.	1976	134813
site of hydrolysis of collagen by hot trichloroacetic acid.	when calfskin collagen is treated with trichloroacetic acid at 90 degrees c, it is hydrolyzed to a mixture of peptides, some of which are quite small. cleavage of collagen by acid seems to occur at bonds between proline (or hydroxyproline) and other amino acids, with only a limited specificity for which amino acid donates its amino group to the susceptible peptide bond.	1976	134865
dynamics of sulfonylurea-induced insulin release from the isolated perfused rat pancreas.	in the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. novocs 476, a new and potent sulfonylurea, and glibenclamide qualitatively differed from tolbutamide, glibornuride, glipizide, and glisoxepide, which were all alike in terms of the relationship between first and second phases of insulin release.	1976	134920
control of synthesis of mrna's for t4 bacteriophage-specific dihydrofolate reductase and deoxycytidylate hydroxymethylase.	a 30 degrees c, functional messengers for dcmp hydroxymethylase first appeared 3 to 6 min postinfection and reached their maximum levels at 12 min. chloramphenicol, added before the phage, reduced the rate of mrna accumulation. when the antibiotic was added 6 min postinfection, mrna levels increased at their normal rate but there was no obvious repression of messenger accumulation. delaying the addition of drug until 8 or 12 min had progressively less effect on the pattern of hydroxymethylase mr ...	1976	135096
[tuberculosis in domestic animals and its relationship with human tuberculosis].		1976	135254
[comparative study on lymphocyte stimulation by pha and bacterial endotoxins, particularly in malignant tumor and allergy patients].	in a group of 37 tumor patients with predominantly advanced disease, lps stimulation (lps of sh. sonnei and sh. flexneri) resulted in a significant increase of the transformation rates caused, most probably, by the high proportion of b cells. on the other hand, allergics (drug allergies) did not differ from controls. it seems possible that b cell stimulation by bacterial endotoxins can be used for the assessment of the reactivity of the organism.	1976	135504
studies of the histochemistry, ultrastructure, motor innervation, and regeneration of mammalian intrafusal muscle fibres.		1976	137430
[diuretic action of calcitonin: demonstration of an inhibiting effect on sodium reabsorption in the ascending limb of henlé's loop].	it was found that calcitonin (porcine) at the dose: 4 i.u. mrc./kg/hr (i.v.), in the rabbit, increased the diuresis and oxmolal excretion, and simultaneously decreased free-water reabsorption and urinary osmolality. the results suggest that calcitonin acts by inhibiting sodium reabsorption in the ascending limb of henl's loop. this hypothesis was confirmed by renal autoradiography study with 22na.	1976	140734
structural studies on d-specific polysaccharide of shigella flexneri serotype 6.		1976	173550
heterotropic interactions of ligands with phosphorylase b.	1. the interaction of rabbit muscle glycogen phosphorylase b with pairs of ligands has been examined. 2. the electron spin resonance spectrum of a spin label, covalently attached to the protein, provided information about dissociation constants, formation of ternary complexes and both negative and positive interactions between different ligand pairs. 3. amp competes with a series of nucleotides (adp, atp, cmp aand cytosine) but with adenosine a ternary enzyme - amp - adenosine complex can be for ...	1976	173552
noradrenergic subsensitivity and supersensitivity of the cerebral cortex after reserpine treatment.	changes in the sensitivity of the cyclic adenosine 3', 5'-monophosphate response of rat brain cerebral cortical slices to norepinephrine were measured in vitro after the rats received i.p. injections of reserpine (1 mg/kg). subsensitivity was evident 1 hour after a single reserpine treatment compared with saline controls. however, if reserpine was injected daily for 4 days followed by 1 day without reserpine treatment, a supersensitive response to ne was shown compared to the controls. mean pd2 ...	1976	173828
a ribosome-dependent gtpase from yeast distinct from elongation factor 2.	three proteins required for poly(u)-directed polyphenylalanine synthesis have been separated from yeast. two of the factors correspond to the elongation factors 1 and 2 described for other eukaryotic systems, according to the criteria of phenylalanyl-trna binding and diphtheria toxin-catalyzed adp-ribosylation. the third protein, while absolutely required for polyphenylalanine synthesis, was a more active ribosome-dependent gtpase than elongation factor 2.	1976	174100
ischemia-induced alterations in myocardial (na+ + k+)-atpase and cardiac glycoside binding.	the effects of ischemia on the canine myocardial (na+ + k+)-atpase complex were examined in terms of alterations in cardiac glycoside binding and enzymatic activity. ability of the myocardial cell to bind tritiated ouabain in vivo was assessed after 1, 2, and 6 h of coronary occlusion followed by 45 min of reperfusion, and correlated with measurements of in vitro (na+ + k+)-atpase activity and in vitro [3h]ouabain binding after similar periods of ischemia. regional blood flow alterations during ...	1976	130383
coordinated, coenzyme q reversible, 2,5-dibromothymoquionine inhibition of electron transport and atpase in escherichia coli.		1976	174563
unrelated animal viruses share receptors.		1976	175292
intracellular forms of epstein-barr virus dna in human tumour cells in vivo.	tumour biopsies from burkitt lymphoma patients, as well as human nasopharyngeal carcinoma cells growing in athymic mice, contain epstein-barr virus dna as covalently closed circular dna. in addition integrated viral dna sequences seem to be present.	1976	176597
[pharmacology of airway mechanics].		1976	176708
effects of cytochalasin b on herpes simplex virus type 1 replication.		1976	176798
[synthesis of virus-specific macromolecules and virion maturation in chick embryo cells infected with sendai virus].	synthesis and accumulation of virus-specific rna, proteins and intracellular nucleocapsids are observed in sendai virus-infected chick embryo cells for approximately 2 days postinfection. however, only an insignificant part of these products leaves the cell as a result of maturation of virus particles. it is suggested that the cause of the ineffective maturation of virions in the system under study may be in the observed instability of one of virus structural proteins in the infected cells, m pr ...	1976	176819
stimulatory actions of thyrotropin and dibutyryl cyclic amp on transcription and translation in the regulation of thyroidal protein synthesis.	when beef thyroid cells were incubated with thyrotropin and then tested for protein synthesizing activity, the stimulatory effect of thyrotropin appeared in two distinct phases: first, an immediate stimulation which continued as long as thyrotropin was present, but died away promptly after withdrawal of the added thyrotropin; and second, a delayed stimulation with a lag period of 1 to 2 h, which persisted after thyrotropin withdrawal. the fast and the delayed effects each stimulated protein synt ...	1976	177054
immunodeficiency in the chicken. iv. an immunological study of infectious bursal disease.	chickens inoculated orally with infectious bursal disease virus (ibdv) 1 day after hatching subsequently showed a 50% incidence of immunodeficiency but little mortality. antibody responses against ibdv and to immunization with sheep red blood cells (srbc) or human serum albumin (hsa) were suppressed. serum igg concentration was decreased while igm occurred exclusively in its 7s monomeric form (migm). an allotypic marker of chicken igm (mla) was lacking in migm derived from ibdv-infected birds. t ...	1976	177236
hepatomas in grs/a male mice treated with horse serum or horse anti-mouse antilymphocyte serum.		1976	177290
[epidemiology of human and animal brucellosis in western africa. the results of six studies in the ivory coast, upper volta, and nigeria].	brucellosis has a two-fold importance in public health: the transmission of the disease to man by contact with animals or ingestion of raw milk is of direct importance; of indirect importance is the loss of animal protein. the authors have carried out ten epidemiological investigations in different bio-climatic zones of west africa. more than 120 villages were evaluated. in each village, 100 persons were chosen at random and all or part of the animal population was also studied. three tests were ...	1976	177324
mononucleosis-associated subacute sclerosing panencephalitis.	a thirteen-year-old girl died of subacute sclerosing panencephalitis (sspe) which occurred as part of a complex encephalitic illness related to acute infectious mononucleosis. the cerebrospinal fluid (csf) epstein-barr virus (ebv) fluorescent antibody (fa) titer was 1:64. electron microscopic examination revealed 17 nanometer (nm) diameter paramyxovirus-like nucleocapsids in brain sections and 90 nm diameter herpes virus-like enveloped particles in negatively stained brain tissue extracts. indir ...	1976	175632
immunopathogenicity and oncogenicity of murine leukemia viruses. ii. infection of mice and rats with scripps leukemia virus.	the pathologic consequences of infection of newborn mice and rats with mulv (scripps leukemia virus--slv) were observed. serum mulv p30 concentrations of most strains were elevated 20 to 100 times that of controls while mulv gp70 levels were elevated only 1.1 to 14.8 times, probably reflecting in part the higher concentrations of gp70 in control sera but also indicating the lack of parallelism in regulation of synthesis of these two viral antigens. infected mice of most strains developed immunol ...	1976	175661
humoral host defense mechanisms against tumors.		1976	176124
mechanism of plasma cyclic amp response to hypoglycemia in man.	the effect of insulin-induced hypoglycemia on plasma cyclic amp levels was studied in normal volunteers, adrenalectomized, and sympathectomized subjects. significant increases in plasma glucagon were observed in all groups. normal subjects all had two- to threefold rises in plasma camp while no response was seen in any adrenalectomized or sympathectomized subject. these findings suggest that the mechanism for enhanced plasma camp release during insulin-induced hypoglycemia is catecholamine depen ...	1976	178982
[effect of migillin on protein synthesis in intact and virally infected tkce and fl cells].	the effect of migillin was studied with respect to protein synthesis in the cells of tkce (transplantable line of cells of the kidneys of cow embryos) and fl--intact and infected with viruses of aphtous fever a22, strain 550 and poliomyelitis of type iii, strain saukett respectively. simultaneously the effect of migillin on sensitivity of the cells to the above viruses was tested. the synthesis of protein was determined by incorporation of c14-glycine into the acid insoluble fraction of the cell ...	1976	179466
secretory processes, carbohydrate and lipid metabolism in isolated mouse hepatocytes. aspects of regulation by glucagon and insulin.	the procedure of berry and friend for isolation of intact hepatocytes has been adapted to mouse livers. the ultrastructure of these cells was satisfactorily preserved. isolated mouse hepatocytes secreted proteins and triacylglycerols. these secretory processes were inhibited by colchicine, indicating a likely involvement of the microtubular system for their normal occurrence. ultracentrifugation of medium incubated with hepatocytes, followed by electrophoresis and electron microscopic examinatio ...	1976	179577
endonucleolytic cleavage of murine leukemia virus 35s rna by microsome-associated nuclease.		1976	180996
effect of fluorosteroids on drug response and metabolism.		1976	181004
pseudogout: session iii. pathology of cppd crystal deposition: discussion.		1976	181018
augmented immunogenicity of tumor cell membranes produced by surface budding viruses: parameters of optimal immunization.	membranes prepared from tumor cells infected with surface budding viruses are much more immunogenic than membranes from uninfected tumor cells. factors affecting immunization with membranes from virus-infected tumor cells were studied. preparations made with influenza virus were clearly superior to those prepared with vesicular stomatitis virus (vsv). membranes infected with vsv were maximally immunogenic at a dose equivalent to a 10% cell pack whereas influenza-virus-infected membranes were imm ...	1976	182646
[infection of hela cells by herpes virus of horses type 1 in different temperature and dose of the virus (author's transl)].		1976	183896
histochemistry of oxidative enzymes in experimental allergic encephalomyelitis.	the histoenzymic pattern of oxidative enzymes (g3pd, idh, sd, g6pd,hbd, nadph: dehydrogenase) was investigated in experimental allergic encephalomyelitis (eae) produced in rats according to paterson [13]. the results obtained lead to following conclusions: (1) the neuroglia, including the white matter oligodendroglia of immunized rats, exhibits increased oxidoreductase activities; (2) the neuroallergic reaction induces some stimulation of the oxidoreductive metabolism of oligoden-droglia; (3) th ...	1976	186370
[infections transmitted in swimming pools].	public swimmingpools can be the source of infections due to micro-organism such as mycobacterium balnei, adeno and enteroviruses, the virus of plantar warts and molluscum contagiosum, the tric-agent of swimmingpool-conjonctivitis and pathogenic fungi. the transmission of trichomonas vaginalis is considered unlikely-water of pools, supposed to present satisfactory qualities by standard controls, was found to contain pathogenic staphylococci and pseudomonas aeruginosa. effective preventive measure ...	1976	186978
transfer of parental immunity to infectious laryngotracheitis in chicks.	the transfer of parental immunity to infectious laryngotracheitis was appraised by measuring serum antibody levels in 150 chicks from the day of hatch up to five weeks. the breeder flock which had received primary vaccination at eight weeks and a booster at 20 weeks transferred high antibody levels which fell markedly within two weeks and remained constant thereafter. chicks whose parents were vaccinated at 20 weeks only, had low antibody levels throughout. these low levels, in either group of c ...	1976	187298
comparative in vitro studies of cinoxacin, nalidixic acid, and oxolinic acid.	cinoxacin and nalidixic acid were found to be similar in in vitro activity against 138 shigella isolates and somewhat less active than oxolinic acid on a weight basis. cross-resistance developed when 10 shigellae were transferred on increasing amounts of the respective agent contained in mueller-hinton agar. plate dilution studies of the effect of changes in agar ph on the minimum inhibitory concentration revealed that the antibacterial activity increased with decreasing ph. protein binding inve ...	1976	12717
[role of several functional groups in the biological activity of allergenic preparations].		1976	66777
the cutaneous reactions to kallikrein, prostaglandin and thurfyl nicotinate in chronic urticaria and the effect of polyphloretin phosphate.	the erythema and wealing resulting from the application of thurfyl nicotinate ointment (trafuril) and from the inoculation of kallikrein has been studied in patients with chronic urticaria and normal controls. polyphloretin phosphate (ppp) suppressed the reaction in controls but in patients with urticaria it increased the reactions to trafuril and had little effect on the kallikrein reaction. ppp also suppressed the pge2-induced erythma in normal controls but not in urticaria patients. in a sepa ...	1976	59506
studies on the pathogenesis of enteric infections caused by invasive bacteria.	salmonellae, shigellae and some escherichia coli must invade the intestinal epithelial cell and multiply within the mucosa to cause disease. although the bacterial cell most likely possesses several properties essential to this invasive ability, the nature of the cell envelope complex is at present the only characteristic which has been implicated in this process. while a number of pathophysiological events result from invasion, some of our recent efforts have concerned the site and mechanism of ...	1976	62646
levamisole in advanced human breast cancer.	a clinical trial of levamisole, an orally effective modifier of the immune response, is reported in women with primary inoperable breast cancer (stage iii). after being rendered clinically disease-free by radiotherapy to the breast, supraclavicular area, and axilla, patients were allocated alternately to a control group (no further treatment) and a levamisole-treated group (150 mg orally three times a week on alternate weeks) and were followed-up by physical examination and laboratory tests. in ...	1976	55529
[sensitivity of dysentery bacteria to furazolidone and phthalazol according to the materials of medical epidemiological station of odessa-kishinev railroad].		1976	58090
trimethoprim-sulfamethoxazole therapy for shigellosis.	twenty-eight infants and children hospitalized for severe shigellosis were treated orally either with ampicillin trihydrate (100 mg/kg/day administered in divided doses every six hours) or with trimethoprim-sulfamethoxazole (trimethoprim, 10 mg; sulfamethoxazole, 50 mg/kg/day in divided doses every 12 hours) for five days. four patients with ampicillin-resistant shigellae continued to have diarrhea and positive stool cultures during therapy. patients with susceptible shigellae treated with ampic ...	1976	765518
diagnostic value of indirect hemagglutination in the seroepidemiology of shigella infections.	to evaluate the usefulness of the indirect hemagglutination (iha) test in the epidemiological investigation of shigellosis, single serum specimens were tested from 50 patients with shigella dysenteriae 1 (shiga bacillus) infections, 103 asymptomatic contacts of these cases, 267 adult and 100 student control, and serum specimens collected during two outbreaks caused by s. sonnei and one outbreak due to s. flexneri 6. in patients with s. dysenteriae 1, 74% demonstrated titers of greater than or eq ...	1976	767361
[intestinal localization of shigellae in dysentery and experimental shigellosis].	the investigation of 53 section cases of dysentery and 18 biopsy specimens of the large intestine in acute dysentery in children showed that intrapithelial distribution of shigella was not always regular. in studies of experimental shigellosis on isolated loops of the intestine 459 segments of the intestine of 51 rabbits were investigated. the results obtained showed that shigella multiplied mainly in the lumen of the intestine. the increase in number of shigella in enterocytes was by 8-9 orders ...	1976	769758
shigella hepatitis.		1976	775138
[correlation between biochemical features and pathogenicity of shigella. iv. threonine deaminase of shigella strains producing and not producing keratoconjunctivitis in guinea pigs].		1976	775224
isolation and analysis of the lipid a backbone. lipid a structure of lipopolysaccharides from various bacterial groups.	a degradation procedure of lipopolysaccharides was worked out which allows the isolation of the reduced backbone of lipid a in a total yield of between 20 and 30%. this procedure was applied to lipopolysaccharides of s forms (salmonella minnesota, shigella flexneri 5b, escherichia coli 086, e. coli 0111, xanthomonas sinensis, rhodopseudomonas gelatinosa) and r mutants (salmonella minnesota, shigella flexneri, 5b, e. coli bb9 and e. coli eh 100). chemical analysis, reaction with beta-n-acetyl-glu ...	1976	770165
shigella flexneri 6 biotypes: a review.	except in gas production, s. flexneri 6 is generally similar to other s. flexneri. s. flexneri 6 contains both aerogenic and anaerogenic strains which are identical serologically. it is not surprising that s. flexneri 6 is not separable from other s. flexneri types on the basis of dna relatedness (overall genetic makeup) (4). the manchester biotype is seen in the united states, and is easily separable from other enterobacteriaceae by biochemical tests. one can no longer assume à priori that any ...	1976	776900
[the role of the water factor in the spread of dysentery on river vessels].	results of epidemiological and statistical analysis of the indices of dysentery morbidity and bacteriological examination of drinking water pointed to the significant role of the water factor in the spread of dysentery on the river vessels.	1976	782097
[increasing the frequency of the transmission of antibiotic resistance in bacteria through their centrifugal sedimentation].		1976	782110
[use of the vshs elective-differential medium in the diagnosis of dysentery and other acute intestinal infections].	results of trial of the vshs medium under conditions of direct seeding feces of patients suffering from dysentery and other acute intestinal disturbances demonstrated that by the efficacy of sh. sonnei isolation it failed to differ from ploskirev's bactoagar, was less effective in comparison with levin's medium with levomycetin (the incidence of shigella isolation was 49.7, 52.6 and 60.3%, respectively) and was the most effective in sh. newcastle isolation. in seeding feces after their enrichmen ...	1976	782114
antigenicity testing of inactivated oral enteric bacterial vaccines for human use.	this study deals with the laboratory testing of the antigenicity of inactivated oral enteric bacterial vaccines for human use, viz. typhoid, dysentery, escherichia coli and cholera vaccines. for the assays the following methods are applied : 1) various types of active mouse protection tests 2) serum and coproantibody determinations in immunized persons and experimental animals, 3) protective ability of the immune sera in mice and embryonated eggs, 4) hemolytic and bacteriolytic plaque assays. it ...	1976	782974
[epidemiology of bacterial dysentery in the usa].		1976	785885
[antibody-containing cells in the mucosa of the large intestine of patients with acute bacterial dysentery].	the authors traced the dynamics of appearance, increase and disappearance of o-antibody-containing cells in the mucosa of the distal portion of the large intestine in patients suffering from acute sonne and flexner dysentery (aspiration biopsy of the mucosa). the antibodies were revealed by the indirect coons method. the total number of cells per 1 mm2 of 4 mum of the mucosal section the number of lymphoid cells and the content of the antibody-containing cells in % per total cell count of the ly ...	1976	785886
fecal steroids in diarrhea. i. acute shigellosis.	fecal bile acid and neutral sterol patterns of five healthy adult male volunteers, who were challenged by a virulent shigella flexneri 2a (m42-43) strain and developed dysentery were studied. it was observed that cholic acid was increased from 1.9 +/- 0.4% of total bile acid in the feces before infection to 14.5 +/- 2.1% during diarrhea (p less than 0.001). chenodeoxycholic acid also was increased from 3.2 +/- 0.7 to 8.7 +/- 3.2% in diarrhea but the difference was not significant statistically. ...	1976	786002
[ 771 shigella strains isolated in a 15-year period from americans living in ankara. comparisons with shigella strains isolated from turkish natives].	the author had worked as a bacteriologist in ankara american air force hospital from 1958 to 1972. during this period of time he was able to isolate 771 shigella strains from the american patients of the hospital. the amounts and the percentages of the subgroups are listed below together with the two other ankara city pediatric hospital results (see article). american community lived in ankara for 15 years and shared many aspects which were important in shigella epidemiology like using city's ta ...	1976	790107
shigellosis in custodial institutions. v. effect of intervention with streptomycin-dependent shigella sonnei vaccine in an institution with endemic disease.	a double-blind controlled field trial of live, oral, streptomycin-dependent shigella sonnei vaccine was begun in an institution with endemic s. sonnei disease. considerable unexpected child-to-child transmission of the vaccine strains inadvertantly caused the field trial to resemble a mass vaccination campaign. although s. sonnei accounted for 90% of shigella infections from 1968 to 1971 and three-fourths of the cases occurred in the seven study cottages, s. sonnei disease disappeared following ...	1976	779465
proceedings: inactivation and mutation of cultured mammalian cells by radiations of different let.		1976	779917
serum amylase in rats following the administration of endotoxin.		1976	781914
fluid and electrolyte transport in rhesus monkeys challenged intracecally with shigella flexneri 2a.	shigella flexneri 2a is an invasive enteric pathogen that may produce diarrhea when ingested by human beings and subhuman primates. we have previously shown that shigella diarrhea correlates with water and electrolyte transport abnormalities in the jejunum and colon. dysentery alone is associated only with colonic transport abnormalities. to define the relationship between invasion and inflammation of the colon and the occurrence of jejunal transport abnormalities, we studied water and electroly ...	1976	823110
glycerol dissimilation and its regulation in bacteria.		1976	825019
irradiation of cells by single and double pulses of high intensity radiation: oxygen sensitization and diffusion kinetics.	the biological effects of ionizing radiation in living cells are the ultimate result of a long chain of events with the initial step being the local absorption of radiation. whereas such physical abosrption is probably over within 10(-16) s after dose delivery, the biological consequences of radiation do not manifest themselves until very much later times. between these two extremes of time, events occur relatively early at the molecular level which are undoubtedly critically related to the stil ...	1976	826371
recurrent urinary tract infection due to shigella flexneri--case report.	a case of urinary tract infection due to shigella flexneri is reported. the case presented suggests that in persistent and recurrent urinary tract infection in topical countries, investigations for organisms such as shigella flexneri should be considered. urinary tract infection due to shigella flexneri is unknown and as far as we known has not been reported in the literature. a case report is presented in whom recurrent urinary tract infection was due to shigella flexneri and was treated effect ...	1976	826670
[use of the neutralization test for mass population studies].	the authors applied the antibody neutralization test (ant) for detection of causative agent of intestinal infections in feces of healthy population in turkmenia. some part of the material was studied in parallel with the aid of the ant and by the bacteriological method. as a result of comparison it appeared that in using the ant causative agents of intestinal infections were revealed much more frequently than by the bacteriological method; in this connection this serological method can be recomm ...	1976	828825
shigellosis transmitted by nurses.	twelve cases of shigella sonnei infection, with two deaths, occurred at a custodial institution in donelson, tennessee, in april and may 1973. nine of the cases and both deaths were in patients hospitalized at the institution's infirmary. the patients with nosocomial shigellosis were significantly younger and had been hospitalized significantly longer than controls. epidemiologic investigation implicated staff members in the transmission of illness from one patient to another and identified the ...	1976	790590
[cytotoxic factor of flexner shigella, its biologic function and genetic control].		1976	790817
[role of the cytotoxicity of shigellae in the infectious process].		1976	790818
[realization of the cytotoxic properties of flexner shigellae in a macrophage culture at the cellular and subcellular level].		1976	790819
[change in the virulence of flexner shigellae following transmission of several parts of chromosomes related to the synthesis of o-antigen lipopolysaccharide from e coli k-12 and r-mutants of shigellae].		1976	790821
[comparative study of the virulence of an antibiotic-sensitive strain of flexner dysentery and its exconjugants with different r-factors acquired in the experiment].		1976	790825
[transmissive plasmid determining hemolysin production and synthesis of thermolabile k-antigen].		1976	790826
on the metabolic characteristic of hybrids shigella flexneri x escherichia coli devoid of their ability for intracellular multiplication in the epithelial cells. i. glycolysis.	the glycolysis (aerobic and in the presence of kcn) of avirulent xyl+ and xyl-str hybrids sh. flexneri x e. coli, devoid of their ability to multiply intracellularly in the epithelial cells, is studied. it is established that their glycolytic activity is considerably higher than the activity of the donor strain e. coli, and deviate significantly compared with shown activity of the virulent recipient strains sh. flexneri. xyl-str hybrids are showing high values of glycolysis in aerobic conditions ...	1976	790853
on the metabolic characteristic of hybrids shigella flexneri x escherichia coli devoid of their ability for intracellular multiplication in the epithelial cells. ii. catalase and phosphatase activity.	the catalase and phosphatase activity of avirulent by keratoconjunctival test of guinea pigs xyl+ and xyl-str (kcp-) hybrids that have lost their ability for intracellular multiplication, received from virulent strains. sh. flexneri (sh. flexneri 222 5 a and sh. flexneri m42-43) and donor strain e. coli ab 313 was investigated. it is established that there is a definite dependence between the changes in the catalase and the phosphatase activities of the hybrid strains and the newly received by t ...	1976	790854
shigellosis in the united states: ten-year review of nationwide surveillance, 1964-1973.	in the 10 years 1964-1973, 105,832 isolations of shigellae were reported to the center for disease control through a nationwide surveillance system. the number reported increased by approximately 13% annually, from 5852 in 1964, when only 17 centers reported all 4 quarters; to 16,797 in 1973, when 52 centers reported each quarter. the rate of reported isolations varied from 4.6 per 100,000 persons in 1965 to 9.1 per 100,000 in 1973. shigella sonnei accounted for 64% of all these isolates and for ...	1976	790947
[effect of specific sensitization of the body on the clinical symptoms of dysentery].		1976	793040
studies on the energetic metabolism of shigella flexneri x escherichia coli hybrids devoid of penetration ability. iv. growth characteristics in the presence of some tricarboxylic acid cycle intermediates.	the dynamics of avirulant lac+kcp- hybrids sh. flexneri multiplication was investigated in minimal medium in the presence of some tricarboxylic acid cycle intermediates (fumarate, succinate, malate) and pyruvate. it was established that in spite of the loss of virulence in the rate of the multiplication of the hybrid strains, in comparison with that of the virulent recipient strains of sh. flexneri, considerable differences were not observed.	1976	793258
[free amino acid content in the blood and urine from the use of monomycin on children with dysentery].	the progress of acute dysentery in 73 children at the age of 1 to 14 years treated with monomycin and the levels of free amino acids in the blood and urine in dynamics were studied. it was found that the blood levels of 6 amino acids in the children treated with the antibiotics significantly decreased, while those of 3 amino acids increased as compared to the levels of the same amino acids in the children treated without the antibiotics. it was concluded that the diet of dysentery children treat ...	1976	793513
[change in the sensitivity of dysentery bacteria to certain antibiotics, furazolidone and antifungal preparations when cultured together with candida albicans].	the effect of candida albicans (2 collection cultures and 1 freshly isolated culture) on sensitivity of dysentery bacteria (5 zonne strains, 4 flexner strains and 2 newcastle strains) to antibiotics, furazolidone and their combinations with nystatin or decamine was studied by the method of serial dilutions. a total of 937 tests were performed with the use of 10 concentrations in each test. it was found that sensitivity of the shigella to levomycetin succinate, monomycin and furazolidone decrease ...	1976	793515
studies on the relationships between the immunogenicity and catabolism of antigens and their binding to the surface of macrophages.	the relationship between immunogenicity of shigella paradysenteriae, the branched synthetic polypeptide poly-l (tyr, glu)-polylpro-polyllys [(t, g)-pro--l] and human albumin (hsa) interacting with macrophages and kinetics of antigen degradation and degree of binding to the cell surface was studied. following thioglycollate inoculation into c57bl/6 mice, the peritoneal-stimllated macrophages had higher levels of hydrolases as compared to unstimulated cells. the lysates of the stimulated macrophag ...	1976	793850
[formation of f'-episomes in flexner shigellae].	genetic characteristics of shigella flexneri virulent donor strain 3s, isolated in the laboratory, are studied. the data obtained showed that sh. flexneri 3s 6832 is of f'protype it did not transmit even closely located chromosome markers, except pro+. the transition of pro+ marker was reproduced in reca- strain. f'pro plasmid was eliminated with a frequency similar to that of f'lac factor in the control strain of escherichia coli. the study of virulence by means of keratoconjunktival test revea ...	1976	793929
phage-dependent changes in shigella flexneri type antigen synthesis.	lysogenic conversion of shigella flexneri type antigens was studied with the aid of wild-type and thermosensitive mutant phages. with all wild-type phages, the appearance of glycosylated antigen was accompanied by the appearance of polyprenyl phosphate glucose synthetase activity. with some of the mutant phages, the appearance of glycosylated antigen was not followed by the formation of lipid-linked glucose in the enzyme assay. the reverse has also been observed, i.e., the high rate of formation ...	1976	793990
[comparative susceptibility of animals to sonne and flexner dysentery].		1976	794642
[importance of cellular and humoral immunity factors in dysentery in children].		1976	795153
[interaction with the hep-2 epithelial cells of sh. flexneri r mutants and hybrids differing in o antigen structure].	the results of a study of the interaction of the r-mutants of sh. flexneri of various chemotypes and shigellae hybrids with a definite genetic characteristics differing by structure of the o-antigen labeled with 3h-glucose, with the cells of the hep-2 line demonstrated that the presence of the full value lipopolysaccharide structure apparently promoted the fixation of shigellae to the epithelial cells. the rough shigellae strains could retain the capacity to penetrate into the cells and to multi ...	1976	795229
[changes of various factors of nonspecific humoral immunity in acute dysentery].	the level of total enterobacterial enterotoxins of the blood serum, of beta-lysins, lysozyme activity, complement and normal antibodies were studied in 191 patients with acute flexner dysentery and in 285 patients with acute sonne dysentery, depending on the period of the disease, its severity, the treatment applied, and the species of the causative agent. the level of the nonspecific humoral immunity factors increased before the treatment and its normalization depended on the treatment applied.	1976	795232
[a study of pancrealysates of sh. flexneri 2a and sh. sonnei fractionated by filtration through sephadex g-200 and ultracentrifugation].	a high-molecular fraction of the o-antigen of sh. flexneri and sh. sonnei was isolated from the antigen complex by gel-filtration through sephadex g-200 and ultracentrifugation. the high-molecular fraction obtained by ultracentrifugation at 105000 g contained no low-molecular components.	1976	795248
[ultrastructural features of the interaction of salmonellae and shigellae with the cell].		1976	796637
[dysentery in the city of białystok in the years 1961-1974].		1976	796895
[role of colicinogenicity in the mechanism of the antagonistic action of sonne and flexner shigellae].		1976	797188
[ultrastructural changes in mucosa of the distal portion of the large intestine of patients with dysentery].	the ultrastructure of the mucosa of the large intestine was studied in 10 patients with acute dysentery. the group of patients included 7 women and 3 men aged 17--50 years. diagnosis was confirmed in all cases bacteriologically (by isolation of sonne shigella in 4 patients and flexner shigella in 6 patients). the electron-microscopy study of bioptats of the mucosa showed that in the inflammatory process all its cells--prismatic, gobletcells, and enterochromaffin -- took part, although not in the ...	1976	797360
r factors derived from shigella flexneri strains.	of 2492 shigelle flexneri strains isolated from dysenteric patients in hungary in the years 1972-1974, 767 (30.8%) were resistant to 1-5 antibiotics. resistance was due to r factors in 79.2% of the strains. fertility inhibition experiments with f specific phages showed r factors to be fi+ in 12.9% and fi- and 87.1%. of the antibiotic markers, the chloramphenicol-tetracycline resistance determinant was the most common (46.4%). chloramphenicol resistance determinants were carried out by fi- r fact ...	1976	798470
restriction and modification of shigella flexneri phages by r factors.	out of 420 r factors derived from shigella flexneri strains, 50.8% restricted escherichia coli and s. flexneri phages. phage restriction was produced both by fi- and fi+ r factors. the r factors were divided into nine groups on the basis of the efficiency of plating of s. flexneri phages. changes of phage types were produced by transferring r factors of different restrictive types. the changes offered some information concerning the evolution of phage types. studies on phage modification support ...	1976	798471
[chemotypes of "shigella flexneri" r mutants and related phage receptors. ii. -- localization of phage receptors (author's transl)].	receptor sites for phages fp3, v, p1kcvir, h+, c21, t4, t3, t7 and 6sr have been investigated, by comparing the lytic activity of these phages on r mutants of strain f6 (f6r) and of various serotypes (fh) of shigella flexneri with their inhibition by the lipopolysaccharides isolated from these mutants. the results suggest the following localizations for the receptor sites: phage fp3: lipid a-kdo; phage v: heptose or glucose; phage c21: heptose-glucose; phages h+, p1kcvir, t4 and t3: glucose; pha ...	1976	798512
[chemotypes of "shigella flexneri" r mutants and related phage receptors. i. -- chemical study of the lipopolysaccharides (author's transl)].	the f6r rough mutants isolated from shigella flexneri f6s, serotype 5b, and the fh rough mutants, derived from other serotypes of s. flexneri, were chemotyped according to the chemical analysis of their lipopolysaccharides. further, the following stages of lipopolysaccharide core biosynthesis in s. flexneri have been established: --(kdo)3--heptose--heptose--glucose--galactose; the last three stages are: either --glucose--glucosamine--glucose, or --glucosamine--glucose--glucose. the results of th ...	1976	798513