Publications

differential binding of penicillin by membrane fractions from penicillin-susceptible and -resistant gonococci.	an inverse relationship between binding of [(14)c]penicillin to cells of neisseria gonorrhoeae and the minimal inhibitory concentration of penicillin was recently reported by us. herein we report a similar relationship in binding by cytoplasmic membranes derived from 10 strains of gonococci. membranes were extracted after braun homogenization and differential centrifugation of the resulting extracts. membranes derived from penicillin-susceptible cells bound 140 to 200 nmol of [(14)c]penicillin p ...	1978	96727
phospholipid content and activity of pure uridine diphosphate-glucuronyltransferase from rat liver.	rat liver phospholipids were radioactively labeled in vivo before purification of udp-glucuronyltransferase to homogeneity. the pure enzyme contained very little phospholipid (approx. 0.7 mol of phospholipid/mol of protein). the solubilization detergent lubrol 12a9 appeared to act as a phospholipid substitute, capable of supporting udp-glucuronyltransferase activity. phospholipase c did not inhibit the pure enzyme activity and pure udp-glucuronyltransferase was stimulated by 40--100% by the addi ...	1978	96816
regulation of the in vitro synthesis of the alpha-peptide of beta-galactosidase directed by a restriction fragment of the lactose operon.		1978	96823
differential effects of prostaglandin synthetase stimulators on inhibition of cyclooxygenase.	the different effects of prostaglandin synthetase stimulators on inhibition of the cyclooxygenase by structurally distinct classes of nonsteroidal antiinflammatory agents suggest that the enzyme is altered by interaction with these stimulators. reversible stimulation of prostaglandin synthetase activity by phenols and some other compounds and the relative influence of these stimulators on inhibitors of the cyclooxygenase were determined quantitatively. two distinct classes of inhibitors were est ...	1978	96853
[nonspecificity of antiviral protein action].	the authors studied the antiviral activity of the informative rna of antiviral protein (m-rna avp) isolated from the cells following superinduction of interferon in them for the purpose of ascertaining the action specificity of the product of their translation--avp. following the administration of m-ran avp a marked (from 1 to 5 lg pfu/mil) reduction of the infectious titres was observed in the homologous and heterologous cells. rna preparations from control (noninduced) cells possessed a weak ( ...	1978	96890
metabolism studies with practolol [proceedings].		1978	96899
release of dopamine in the nucleus accumbens of rats by thyrotropin releasing hormone (trh) [proceedings].		1978	96901
changes in responsiveness of medial preoptic neurons to the microelectrophoresis of releasing hormones as a function of ovarian hormones.		1978	96913
bovine transferrin glycopeptide: the relevance of its structure to interaction with the mammalian hepatic lectin that binds asialoglycoproteins.		1978	96919
amino acid sequence alignment of bacterial and mammalian pancreatic serine proteases based on topological equivalences.	the three-dimensional structures of the bacterial serine proteases sgpa, sgpb, and alpha-lytic protease have been compared with those of the pancreatic enzymes alpha-chymotrypsin and elastase. this comparison shows that approximately 60% (55-64%) of the alpha-carbon atom positions of the bacterial serine proteases are topologically equivalent to the alpha-carbon atom positions of the pancreatic enzymes. the corresponding value for a comparison of the bacterial enzymes among themselves is approxi ...	1978	96920
role of pyridoxine in the metabolism of putrescine in the rat.	1. the ability of rats to metabolize radioactive putrescine to 14co2 in vivo has been studied. 2. animals made deficient in pyridoxine exhibit a significantly lower rate of catabolism of the diamine. 3. there dose not appear to be an important interaction between the effects of the deficiency and those stemming from treatment of the animals with the diamine oxidase inhibitor aminoguanidine. 4. these results favour the concept of a role of pyridoxal cofactor in the metabolism of diamines, presuma ...	1978	96921
test for differentiation of m. tuberculosis and m. bovis from other mycobacteria.	a test is described for selective inhibition of mycobacterium tuberculosis and m. bovis isolates in fluid medium. the method employs rho-nitro-alpha-acetyl-amino-beta-hydroxy-propiophenone (nap) as an inhibitory agent for differentiation of mammalian tuberculosis strains from other mycobacteria.	1978	96930
[effect of valinomycin on mitotic activity and ciliary movement during embryonic development].	the k+ ionophore valinomycin very quickly arrests cleavage in sea urchin and mouse eggs at concentrations ranging between 10 and 3 micron. development of axolotl and xenopus eggs is not arrested before the blastula or gastrula stage. the motility of sea urchin sperm, blastulae and gastrulae is suppressed, within a few minutes, by 1-9 micron valinomycin.	1978	96956
[stimulation of pituitary lh and fsh secretion after immunoneutralization of endogenous substance p in the cycling rat].	in the cycling female rat, administration of substance p antisera performed at noon on the proestrous day provokes a significant increase in lh and fsh serum level, right before or after the preovulatory surges, but had no effect on its occurrence or magnitude. these results suggest that substance p has a normal physiological inhibitory role in gonadotropin regulation.	1978	96967
[effect of inhibitors of polyamine biosynthesis on primary differentiation of mouse egg].	alpha-methylornithine, an inhibitor of the synthesis of putrescine does not affect the cleavage of mouse eggs, cultured in vitro from the 2-cell stage, before blastocyst formation, whereas methylglyoxal-bis (guanylhydrazone), an inhibitor of the syntheses of spermidine and spermine induces the embryos to become quiescent at about the 8-cell stage; resumption of their development, after transfer to fresh medium, is followed by a delay in cavitation. these results may be related to the biological ...	1978	96982
[host-virus relationship during experimental spring viremia in carp].	one-summer-old virus-free carps produce both circulating interferon and neutralizing antibodies when stored at +20 degrees c and injected intraperitonealy with 10(5), 10(6), 10(7) p. f. u. of spring viremia of carp virus per fish: kinetics and intensity of interferon production are maximum for the highest virus imput (fig.) and neutralizing antibodies are present in most of the fish 2 1/2 months post infection (table).	1978	96984
[functional study of the rat olfactory bulb by a 14c-2-deoxyglucose autoradiographic technic].	the autoradiographic method has been used in the rat to map active regions in the olfactory bulb after a pulse of 14c-2-deoxyglucose with electrical stimulation of the lateral olfactory tract. the highest optical densities were found at the external plexiform, mitral, internal plexiform and granular layers; the lowest was found in the glomerular layer.	1978	96988
[binding of 3,3',5'-triiodo-l-thyronine (rt3) to human serum proteins].	the rt3-binding and human serum proteins was directly studied with tracer doses of radioactive rt3. polyacrylamide gel electrophoresis showed 125i-rt3 added to human serum was distributed among two proteins: albumin (carrying 57% of tracer rt3) and tbpa )22%). no binding was observed to tbg, protein binding t4.	1978	96994
external neuroanatomy of old world monkeys (cercopithecoidea).		1978	97050
picosecond detection of bchl-800 as an intermediate electron carrier between selectively-excited p870 and bacteriopheophytin in rhodospirillum rubrum relaction centers.		1978	97097
coagulation changes following vasectomy: a study in primates.	thirty vasectomized rhesus monkeys were tested for changes in coagulation factors that might reflect an increased incidence of thrombosis. the results of tests on these monkeys were compared with results of tests on 18 control rhesus monkeys; there were no significant differences between control and vasectomized animals for any of the parameters tested. one vasectomized animal had increased levels of fibrin monomer in his plasma on repeated samples, but no evidence of thrombosis on postmortem ex ...	1978	97098
demonstration of k88ac and k88ab antigens of escherichia coli by means of immunoelectrophoresis and immunodiffusion.	five strains of escherichia coli were tested for the presence of the k88ac or k88ab antigens by immunoelectrophoresis and immunodiffusion. the k88ac antigen of 0a2 and sojka abbotstown gave an anodic line in the immunoelectrophoresis test and a line in immunodiffusion with homologous k88ac antisera. the k88ab antigens of 0g7, 0e68, and moon 263 also gave anodic lines in immunoelectrophoresis, and were detectable by immunodiffusions. the 0 groups of these strains were also demonstrated by immunoe ...	1978	97237
nonrebreathing valve for spontaneously breathing or mechanically ventilated animals.	the design of a small dead space, nonbreathing valve suitable for use in small laboratory animals is presented. the design overcomes previous problems of condensation occurring at valve leaflets, and allows ongoing collection of expired gases should the animal require mechanical ventilation. the valve apparatus performs reliably when in operation for several hours at a time with a variety of small animals.	1978	97251
role of exotoxins in bacterial pathogenicity.		1978	97256
dichroism of bacteriochlorophyll in chromatophores of photosynthetic bacteria.	the dichroism was measured in films of air-dried and, consequently, flattened chromatophores of chromatium vinosum, rhodopseudomonas sphaeroides and rhodospirillum rubrum. the values (deltaa/a) of dichroism in c. vinosum were found to be -1.05 at 590 nm and 0.75 in the near infrared region. the values of dichroism in r. sphaeroides were -0.70 at 590 nm and 0.80 at 870 nm. the values of dichroism in r. rubrum were -1.45 at 590 nm and 0.97 at 870 nm.	1978	97281
amino acid sequence of beta-galactosidase. v. isolation and sequences of chymotryptic peptides.	the amino acid sequence of 72 chymotryptic peptides isolated from 14c-, 3h-labeled carboxymethyl-beta-galactosidase has been determined. a variety of techniques were used in the isolation procedures including separation by solubility, size, and ion exchange and paper chromatography. these peptides contain approximatley 500 amino acids, range in size from 2 to 26 residues, and give overlaps with tryptic peptides of 16 to 55 residues. peptides from this digest and those reported earlier from trypt ...	1978	97293
discrepancy between results of the streptozyme test and those of the antideoxyribonulcease b and antihyaluronidase tests.	comparison of the serum titers obtained with the streptozyme, the antistreptolysin o, the antideoxyribonuclease b, and the antistreptohyaluronidase tests suggested that the streptozyme test had failed to detect antibodies against streptococcal deoxyribonuclease b and hyaluronidase. moreover, sera that were negative in the streptozyme test could be shown by immunodiffusion to possess significant numbers of precipitins against extracellular factors produced by group a streptococci. follow-up studi ...	1978	97311
effect of experimentally induced marginal periodontitis and periodontal scaling on the dental pulp.	experimental breakdown of the periodontal attachment apparatus was produced in six young adult monkeys to study the effect on the tissue of the dental pulp by (1) periodontitis, (2) scaling and plaque accumulation on exposed root dentin. periodontal tissue breakdown was induced by the placement of ligatures around the neck of 92 permanent teeth. subsequent plaque formation caused marked loss of periodontal tissue support, which after a period of 5--7 months amounted to 30--40% of the root length ...	1978	97332
meningitis caused by neisseria meningitidis type w-135.		1978	97374
effects of ethylenediaminetetraacetic acid-4 sodium solution on the surface of renal calculi and the uroepithelium.	tetrasodium ethylenediaminetetraacetic acid is one of the most effective agents that dissolve renal calculi, especially calculi containing calcium. to study the dissolving process of calculi in solutions, with or without trypsin, serial thin sections of renal calculi composed of calcium oxalate and/or phosphate were prepared and observed by polarizing microscopy. the effects of the solution on the surface of human renal calculi and rat uroepithelium also were studied by scanning electron microsc ...	1978	97399
[results of early nutrition of newborn infants with low birth weight. ii. effects of early nutrition on bilirubin metabolism of newborn infants with birth weights from 1501 to 2000 g].		1978	97464
unique behavioral effects of beta endorphin and their relationship to thermoregulation and hypothalamic function.		1978	97480
increased vasodepressor effect of prostaglandins a1 and e1 in renal hypertensive rabbits.		1978	97482
the preparation and use of antibodies as diagnostic biochemical probes.		1978	97493
[multiplication of bdellovibrio bacteriovorus in the cytoplasm of the bacterial host].	the bacterial parasite bdellovibrio bacteriovorus was studied in the process of its interaction with the host bacterium pseudomonas fluorescens. as has been shown by time-lapse microcinematography, along with the normal growth of b. bacteriovorus in the periplasmatic space of the host bacterium, occasionally (4--5%) the parasite is located in the cytoplasm where the complete stage of its intracellular growth takes place with the release of progeny.	1978	97504
functional specialisation in the visual cortex of the rhesus monkey.	anatomical and functional studies of the visual cortex of the rhesus monkey have shown that it is made up of a multiplicity of distinct areas. these seem to be functionally specialised to analyse different features of the visual environment.	1978	97565
biological influence of fat intake on mammary cancer and mammary tissue: experimental correlates.		1978	97651
[method of rapid determination of the cord factor in the mycobacterium colonies on solid nutrient medium].		1978	97660
[virulence of h37rv cultures treated with mycobacteriophages].		1978	97663
helical bacillus subtilis macrofibers: morphogenesis of a bacterial multicellular macroorganism.	helical bacterial macroorganisms have been produced by the selection of appropriate bacillus subtilis mutants and the establishment of specific growth conditions. threadlike fibers ranging in length to approximately 1 cm are produced in fluid culture by the parallel association of many division-suppressed filaments in helical arrangement. a more open ball-like structure of complicated woven architecture may also be produced. macrostructure morphology is regulated by genetic, physiological, and n ...	1978	97671
relationship between the blood concentration of the drug and its cumulative effect: a pharmacokinetic analysis of the nephrotoxic action of gentamicin and streptomycin.	the general principle of dependence of cumulative effects on drug concentration in the blood is proposed. the registered response is regarded as a result of the dual effect of drug blood level and duration of action. the corresponding experimental design consists in maintaining the serum concentration values at several definite levels and determining the response values for each of them. the constant serum level of the drug could be achieved by means of continuous infusion calculated according t ...	1978	97679
effects of learned safety and tolerance on alcohol consumption by the rat.	evidence is presented that learned safety increases the rat's willingness to drink ethanol: induction of tolerance to ethanol following learned safety training produces a further increase. rats with chronically implanted intragastric fistulae consumed substantially more (30%) alcohol when aversive post-ingestional effects were minimized by draining stomach contents during drinking than did rats allowed to retain stomach contents. half the rats from each group were then made tolerant by prolonged ...	1978	97706
the reinforcing property of ethanol in the rhesus monkey ii. some variables related to the maintenance of intravenous ethanol-reinforced responding.		1978	97716
[histochemical changes of intestine epithelium cells of a rat during hipervitaminosis a (author's transl)].		1978	94985
effects of water soluble splenic extracts on intestinal smooth muscle.		1978	34364
[comparative study of interferon production in mice with the graft versus host reaction].	mice with graft versus host reaction (gvhr) show a decreased production of serum interferon and that produced by the bone marrow and spleen cells and blood leukocytes in vitro upon inoculation with newcastle disease virus. interferon induction with lipopolysaccharide of flexner bacteria resulted in activation of production of serum interferon and that induced in spleen cell and blood leukocyte suspensions. serum interferon production after administration of poly(i) . poly(c) was similar in mice ...	1978	34929
the uptake of choline by streptococcus pneumoniae.	uptake of choline, a structural component of pneumococcal c- and f-teichoic acids, into bacteria growing in a defined medium was very efficient with an uptake constant ([s]10 5) of 3.2 microns. it was inhibited by iodoacetate, dinitrophenol and oligomycin but not by structural analogues of choline. ethanolamine, however, was transported in the absence of choline but with a reduced affinity ([s]0.5 71.4 microns). the same constitutive system was probably used by both ethanolamine and choline. it ...	1978	34010
calf liver nuclear n-acetyltransferases. purification and properties of two enzymes with both spermidine acetyltransferase and histone acetyltransferase activities.	calf liver contains two nuclear n-acetyltransferases which are separated by chromatography on hydroxylapatite. both acetyltransferase a and acetyltransferase b will transfer acetate from acetyl-coa to either histone or spermidine. the same protein catalyzes the reaction with both substrates; this is shown by a constant ratio of spermidine to histone activity over a 5,000-fold purification and identical heat denaturation kinetics for both spermidine and histone acetyltransferase activity with eac ...	1978	22543
proteolytic enzymes of the k-1 strain of streptomyces griseus obtained from a commercial preparation (pronase). effect of ph, metal ions, and amino acids on aminopeptidase activity.		1978	22544
beta adrenergic blockade, regional left ventricular blood flow and st-segment elevation in canine experimental myocardial ischemia.	the effects of dl-propranolol, d-propranolol, dl-pindolol and dl-practolol on regional myocardial blood flow (assessed by means of tracer microspheres) and on st-segment elevation in ischemic and nonischemic areas of the canine left ventricle have been investigated. dl-propranolol and dl-pindolol, but not dl-practolol and d-propranolol, induced blood flow redistribution from the epicardium to the endocardium both in ischemic and nonischemic areas. dl-propranolol-induced redistribution was abolis ...	1978	26795
environment and selfsufficiency of elder man (author's transl).	the problems of environment of elderly people are concentrated in social area and in the intimate living space, which can not be maintained sufficiently because of increasing age and decreasing performance. the consequences of mobility in industrial revolution scattered families and also deprived old men of their helpers. inadequate living rooms and absence of technical comfort especially in the houses of the very aged men produce intense dependence of the own individual performance. medical dat ...	1978	27118
neurochemical and operant behavioral studies of a strain of alcohol-preferring rats.	the levels of serotonin (5-ht), 5-hydroxyindoleacetic acid, tyrosine (tyr), norepinephrine (ne), acetylcholine, gaba, glutamate (glu), aspartate (asp), alanine, glycine (gly) and taurine were measured in the cns of adult male rats selectively inbred to the f8 generation for alcohol preference (p) and non-preference (np). with respect to the values found in the np group, higher levels of 5-ht, gaba, glu and gly and lower levels of asp were found in the diencephalon-mesencephalon (d-m) and higher ...	1978	27820
transfer of f'lac+ plasmid from salmonella typhimurium to shigella flexneri.		1978	387348
[effectiveness of using a lyophilized erythocyte antibody diagnosticum and other methods in sonne dysentery].		1978	371282
[characteristics of the action of the biologically active factor from virulent shigella flexneri strains in a study on mice and a cell culture].	the authors subjected to further study the biologically active factor revealed by them earlier in the virulent sh. flexneri cultures by using the genetically bound triad of sh. flexneri 5a-222 cultures and the corresponding couple of sh. flexneri 2a-516. there was shown correlation of the strains virulence determined by the keratoconjunctival test, with the presence of genetically-determined production of the biologically active factor detectable in the culture filtrate, which produced toxic act ...	1978	371290
[media with yeast rna for isolating shigella flexneri from feces].	the authors demonstrated a considerable, in comparison with the control, increase of the biomass of sh. flexneri causative agent, when growing in meat-peptone broth with 1-4 mg of narna, and of the number of colonies in the feces of the patients and of healthy persons artificially contaminated with sh. flexneri when inoculated in ploskirev's agar or endo medium with 4 mg/ml of narna. using media with narna for laboratory diagnosis of dysentery is recommended.	1978	371291
[evaluation of the diagnostic effectiveness shigella sonnei and shigells flexneri antigenic preparations by serological examination data on patients with clinical dysentery].		1978	371292
[indices of peripheral blood lymphocyte blast and macrophagal transformation in typhoid and dysentery in the presence of a bacteriophage homologous to the type of causative agent].		1978	371298
[nomenclature of the bacteria of the genus shigella and their systematic position in the family of enterobacteriaceae].		1978	371309
oxolinic acid for the treatment of chronic gastrointestinal shigella carriers.	two patients were long-term gastrointestinal carriers of shigella flexneri for 23 mo and 6 mo, respectively. neither patient responded to oral antibiotics, despite in vitro sensitivity of the bacteria to the antibiotics administered. oral oxolinic acid produced immediate cessation of the carrier state in both patients, with resolution of minor but persistent physical complaints.	1978	686252
the cellular and humoral immune response after administration to the guinea pig of shigella flexneri 2a t32--istrati vaccinal strain by different routes.		1978	395927
studies on virulence of shigella flexneri.	the antigenic structure and some biological properties were compared in virulent s. flexneri strains of differences in: 1) antigenic composition; 2) biochemical activity; 3) sensitivity to a set of shigella phages and 4) susceptibility to phagocytosis. the only difference found concerned the ld50 for mice; it was 10 to 100 times larger for avirulent than for virulent strains of s. flexneri. the toxic products of the strains were also compared. the lipopolisaccharide and free endotoxin purified f ...	1978	373685
thermosensitive h1 plasmids determining citrate utilization.	twelve thermosensitive h1 plasmids from strains of salmonella typhi that had caused outbreaks of chloramphenicol-resistant typhoid fever in vietnam, thailand and india mediated citrate utilization (cit+) in a prototrophic escherichia coli k12 strain but not in the s. typhi strains from which they were derived. four h1 plasmids from a similar outbreak in mexico differed from the far eastern plasmids in not mediating citrate utlization but in mediating mercury resistance. h1 plasmids resembling th ...	1978	370344
the transfer of antibiotic resistance by r plasmids in shigellae.	forty-five strains of shigella species isolated at auckland hospital from 1972--1974 were investigated for antibiotic resistance. forty-two strains were resistant to one or more antibiotics and 11 strains transferred antibiotic resistance by conjugation to e. coli.	1978	370696
the insensitivity of the chicken eye to the inflammatory effects of x-rays in contrast to its sensitivity to other inflammatory agents.	the effects of x-rays and three chemical agents, known to cause intraocular inflammation in mammalian eyes, were studied on the chicken eye because this species was reported to be insensitive to the cataractogenic effects of x-rays. intravitreal injection of shigella endotoxin and topical and/or intravitreal administration of pge2, pgf2alpha, or arachidonic acid caused a breakdown of the blood-aqueous barrier, as indicated by flare and increased protein concentration in the aqueous humor. follow ...	1978	346520
quantitative toxicology: interlaboratory and intermethod evaluation in new york state.	the new york state department of health has conducted a proficiency evaluation program in quantitative toxicology since 1974. serum samples containing a barbiturate and phenytoin, together with either glutethimide, procainamide, or theophylline, are sent to participating laboratories quarterly. within the first two years of the program the percentage of laboratories able to quantitate 75% of the test samples to within 25% of the gravimetric values increased from 25 (1974-1975) to 40% (1975-1976) ...	1978	343948
eosinophils chemotactic factor (ecf). iv. inhibitory activity in human peripheral leukocytes.	a low molecular weight eosinophil chemotactic factor (ecf) can be released from human peripheral polymorphonuclear leukocytes by phagocytosis, by reverse anaphylaxis or by the calcium ionophore a 23187. during later phases of ecf-release, a leukocyte-derived ecf inhibitor (ldi) is concomitantly released. inhibitory activity is also present in sonicates of unstimulated cells, suggesting that the factor is preformed. on chromatographic analysis of neutrophil (pmn) sonicates, two peaks of inhibitor ...	1978	344231
[clinical and rectoscopic characteristics of dysentery with accompanying helminthic invasion].		1978	344988
enterotoxin production by shigella flexneri type 2a, strain no. m42-43.	enterotoxin produced by shigella flexneri type 2a, strain m42-43, is similar to "shig-like" cytotoxic enterotoxin and shares common features with that of other s. flexneri strains. on the basis of molecular filtration and neutralization experiments it is suggested that the same molecule carries these biological characters.	1978	382758
antilymphocyte antibodies in systemic lupus erythematosus patients and their relatives: reactivity with nonhuman lymphocytes.		1978	414873
[coryneform bacterias of the bovine udder].		1978	414906
immunochemical and biochemical studies demonstrating the identity of a bovine spinal cord protein (scp) and a basic protein of bovine peripheral myelin (bf).		1978	415121
[aggravation of experimental dysentery in mice and acceleration of the process of multiplication of pathogenic and conditionally pathogenic bacteria under the effect of yeast rna].	simultaneous infection of mice with sh. flexneri subtype 2a, culture, with various doses of rna sodium salt (narna) or administration of the preparation 3 hours prior to or 6, 12, and 18 hours after the infection was accompanied by aggravation of the experimental infection in mice. this was expressed in a greater number of animals which contracted the disease and died, and in increased blood and peritoneal exudate microbiol density. the same processes were noted in mice infected with equal doses ...	1978	415460
nature of collagens synthesized by monkey periodontal-ligament fibroblasts in vitro.	1. first subcultures of fibroblast-like cells from adult monkey periodontal ligament were incubated in the presence of 14c-labelled amino acids and produced significant amounts of type-i and type-iii collagens. 2. the proportion of type-iii collagen produced was calculated on the basis of the recovery of procollagens from deae-cellulose chromatography to be approx. 20%, and at least 10% when analysed as collagens on cm-cellulose chromatography. 3. sodium dodecyl sulphate/polyacrylamide-gel elect ...	1978	415740
specific antiserum to the main intrinsic polypeptide of chick lens fiber cell plasma membranes.		1978	415893
pharmacokinetics of intracarotid artery 14c-bcnu in the squirrel monkey.	a comparison of intravenous to intracarotid artery (ica) administration of 14c-bcnu (1,3-bis(2-chloroethyl)-1-nitrosourea) was made in squirrel monkeys. radioactivity was measured as soluble drug products and as rna-, dna-, and protein-bound radioactivity. the ica administration of bcnu achieved 190% to 280% higher brain nucleic acid-bound drug levels than use of the intravenous route in the infused hemisphere and 130% to 280% higher levels than in the noninfused hemisphere. in addition, some br ...	1978	416182
[shigella flexneri diarrhoea with positive blood culture].		1978	16114334
oesophageal reflux and its myths.		1977	421073
[a new technic of substitute stomach formation; merguet's modification].		1977	352030
computer tomography, radionuclide imaging and ultrasonography in hepatic mass lesions.	the livers of 86 patients comprising this report were examined by both transmission computerized tomography (ct) and radionuclide scans (ls). fifty-nine of them were also examined by gray-scale ultrasound (us). in a comparative study, the strengths and weaknesses of each modality were evaluated. ct demonstrated 85%. us 82%, and ls 73% of masses involving the liver. because of better resolution and sectioning capabilities, together with stop-motion imaging, ct and us detected smaller and deeper m ...	1977	421442
in vitro activity of cinoxacin, ampicillin, and chloramphenicol against shigella and nontyphoid salmonella.	the in vitro antibacterial activity of cinoxacin was compared with that of ampicillin and chloramphenicol against 26 strains of nontyphoid salmonella and 44 strains of shigella. cinoxacin was found to have a lower minimal inhibitory concentration than ampicillin and chloramphenicol against all salmonella and shigella sonnei strains. cinoxacin had minimal inhibitory concentrations similar to those of chloramphenicol but lower than those of ampicillin against shigella flexneri and s. boydii strain ...	1977	856008
proposals for quality control methods of bacterial vaccines for immunostimulation. iii. effect of bcg and c. parvum on in vivo listeria clearance and tumor growth.	two quality control methods for bcg and c. parvum are described. first, in vivo macrophage dependent-spleen clearance of listeria monocytogenes in inbred b10lp mice. bcg and c. parvum were administered intravenously prior to listeria inoculation (a prophylactic model). conditions for enhanced listeria clearance including dose, route and time interval were described for each vaccine. next, a tumor model was developed: i.e. a fibrosarcoma, chemically induced by 20-methylcholanthrene in inbred balb ...	1977	415924
presence of common idiotypes on antibodies induced by glutamic acid-lysine-containing terpolymers in responder and nonresponder mice with the ig-1b heavy chain allotype.	a b10.a (5r) responder mouse to the random linear terpolymer, poly--(glu, lys, phe), glphi, can produce immunoglobulins which bind poly-l (glu, lys), gl, that share idiotypic determinants with gl-binding antibodies produced by other members of the same strain. expression of these common idiotypic determinants, termed bgl, is independent of the h-2 halotype and closely linked to the ig-lb heavy chain allotype. moreover, nonresponder mice with the ig-lb heavy chain allotype, when immunized with gl ...	1977	415884
monocyte function in familial mediterranean fever.	monocytes derived from the peripheral blood of patients with familial mediterranean fever (fmf) demonstrated a consistently lower phagocytic capacity (38-44%) for 125i-labelled shigella flexneri when compared to monocytes from healthy subjects. phagocytosis of both viable and killed staphylococcus albus was similar in patients and controls. however, fmf monocytes had a two- to eight-fold depressed bactericidal capacity against s. albus in comparison to normal monocytes. acid phosphatase and beta ...	1977	345807
the aetiology of dysentery-like diseases and the biology of their causative agents.		1977	346997
the role of cellular locomotion in leukemic infiltration. an organ culture study on penetration of l 5222 rat leukemia cells into the chick embryo mesonephros.	the significance of cellular locomotion for leukemic infiltration was investigated using l 5222 rat leukemia cells. previous cinemicrographic studies have shown that these cells are able to locomote only after formation of a uropod-like posterior extension. this characteristic locomotive configuration of l 5222 cells is easily recognizable in scanning electron micrographs and appropriate sections. leukemia cells were inoculated on slices of chick embryo mesonephros incubated for 24h; at this tim ...	1977	403674
neurite induction in mature cortical neurones in feline gm1-ganglioside storage disease.		1977	404568
effects of 19-hydroxy-prostaglandins on oviductal and uterine motility.	the effects of 19-hydroxyprostaglandins (19-oh-pgs) were tested in vivo on the rabbit oviduct and uterus and on the rhesus monkey (macaca mulatta) uterus. the 19-oh-pges suppressed spontaneous oviductal and uterine activity in the rabbit. the qualitative effect on the rabbit oviduct of 19-oh-pges was similar to that of pge2. however, the typical response of the rabbit uterus to pge2 was an increase in muscle activity. with regard to the rabbit oviduct, 19(r)-oh-pge2 was as potent as pge2, but 19 ...	1977	404673
[study of intestinal infections in experiments on monkeys].		1977	410189
oral immunization of monkeys with polyvalent dysentery vaccine.	macaca mulatta monkeys were immunized orally with polyvalent boivin extract of shigella flexneri 2a, 3a, 4a, 4b, 6 and shigella sonnei. the total immumizing dose for each component was equivalent to 1.2 x 10(12) cells. after challenge with 7.5 x 10(10) cells of a virulent s. flexneri 2a strain, out of 20 immunized animals 2 developed dysentery and 4 showed mild dyspepsia; all 6 control animals became ill with dysentery. vaccination failed to influence the incidence, duration or the intermittent ...	1977	412396
[safety and immunologic effectiveness of polyantigen from shigellae for oral immunization of monkeys].	clinical, morphological, and immunological study was carried out in monkeys given shigellae antigen in tablets orally. each tablet contained 0.5 mg of the antigens obtained by boiven's method from sh. flexneri 2a, 3, 4a, 4b, 6 and sh. sonnei. daily administration of the preparation for 4 days and then 4 times at the interval of 5 days proved to be harmless for monkeys. a marked immunomorphological reaction in the form of hyperplasia of the lymphoid elements of the wall of the large intestine and ...	1977	413291
theileria parva piroplasmosis in mice, and its attempted transmission with rhipicephalus appendiculatus ticks.	theileria parva piroplasm infection of mouse erythrocytes was detected, following intraperitoneal inoculation of mice with irradiated cultures of t. parva-infected bovine lymphoid cells. infection could not be transmitted to cattle using rhipicephalus appendiculatus ticks.	1977	414389
the use of tetracyclines on the chemotherapy of experimental east coast fever (theileria parva infection of cattle).	in a series of experiments, groups of cattle, undergoing patent east coast fever (ecf) reactions induced by the inoculation of tick-derived stabilates of theileria parva infective particles, were treated by parenteral administration of 2 tetracyclines. ten cattle were treated with n-pyrrolidinomethyl tetracycline at 15 mg/kg for 5 days, starting on the first day macroschizonts were detected in lymph node biopsy smears. nine of these treated cattle survived ecf reactions induced by an inoculum wh ...	1977	414390
dog bites.	dog bites can be prevented by proper education of children, appropriate selection of family pets and the restraint of guard dogs in the community. an unusually high incidence of bites by german shepherds was observed in this study. treatment of injuries inflicted by dogs should include: careful wound toilet, appropriate excision of damaged tissues, careful wound repair with adequate drainage and systematic therapy with selected antibiotics.	1977	556659
study on the ion-permeability of human dental enamel with special reference to an electrochemical approach.		1977	34011
kallikrein inhibitors in rat plasma.	the kallikrein inhibitor contents of human and animal plasma were determined with glandular kallikreins ec 3.4.21.8. one ml of plasma could inactivate 20-700 kallikrein units (ku). rat plasma was the most potent and inactivated 230-700 ku. however, no enzyme capable of inactivating kallikrein could be found in this plasma. two fractions which inhibited hog pancreatic kallikrein, a fraction corresponding to alpha2-macroglobulin and a fraction which was eluted prior to albumin, were separated from ...	1977	14935
purification and characterization of a plasminogen activator secreted by cultured human pancreatic carcinoma cells.	a plasminogen activator secreted by cultured human pancreatic carcinoma (mia paca-2) cells has been purified to apparent homogeneity by procedures including sepharose-l-arginine methyl ester affinity chromatography, sephadex g-200 gel filtration, isoelectric focusing, and sodium dodecyl sulfate gel electrophoresis. the plasminogen activator shares many properties with urokinase including: molecular weight (55 000), isoelectric point (8.7), heat stability (60 degrees c, 30 min), ph stability (1.5 ...	1977	15590
acute bacteremia in asplenic renal transplant patients.	four cases of overwhelming bacteremia were observed in asplenic renal transplant patients 12 to 20 months after transplantation. the bacteriologic findings and presentation of these infections are characteristic of post-splenectomy sepsis reported in nontransplant patients. it is suggested that the absence of the spleen, more than immunosuppression with azathioprine and prednisone, predisposes to these late, uncommon infections after transplantation.	1977	16144
identification of essential histidine residues of aminoacylase by photooxidation and by reaction with diethylpyrocarbonate.	state and function of the histidine residues of aminoacylase were investigated by photoxidation in the presence of methylene blue and by chemical modification with diethylpyrocarbonate. complete inactivation of the enzyme was observed after oxidation of 4 histidine residues. from the ph dependence of the photooxidation it becomes evident that the inactivation of the enzyme is not a consequence of the simultaneous oxidation of tryptophan residues. the enzyme is also inactivated by chemical modifi ...	1977	17959
detection of salmonella antigens in the neutralization reaction (anr).		1977	17975