Publications

investigation of the chemiluminescence associated with phagocytic and intracellular killing activity of human polymorphonuclear leucocytes and monocytes.	the chemiluminescence associated with phagocytic and intracellular killing activity of human polymorphonuclear leucocytes and monocytes was investigated. a significant, opsonization-dependent increase in photon emission of polymorphonuclear leucocytes and monocytes was observed induced by engulfment of opsonized, heat-killed and living fungi (saccharomyces cerevisiae), aggregated gamma globulin, latex and india ink particles. mononuclear cells displayed only minimal enhancement of photon emissio ...	1978	94028
absence of mutagenicity of praziquantel, a new, effective, anti-schistosomal drug, in bacteria, yeasts, insects and mammalian cells.	praziquantel (embay 8440, droncit) a new, effective anti-schistosomal drug, was tested in various short-term assays that have shown a predictive value for the detection of potential carcinogens. indicator organisms s. typhimurium strains, s. pombe, s. cerevisiae, cultured v79 chinese hamster cells or human heteroploid cells and drosophila melanogaster were treated with praziquantel. the induction of reverse and forward mutations, mitotic gene conversions, x-linked recessive lethals, sister-chrom ...	1978	106268
inosiplex, a stimulating agent for normal human t cells and human leukocytes.	the influence of inosiplex upon various in vitro leucocyte assays was studied in normal individuals. it was found that the drug increases the response of bidirectional and unidirectional mixed lymphocyte cultures at concentrations of 200, 300, and 500 microgram/ml. it also significantly increases the percentage of active t rosettes (concentration range: 50 to 500 microgram/ml) and the percentage of autologous red cell t rosettes (concentration: 100 microgram/ml). in contrast, inosiplex did not m ...	1978	80429
demonstration of specific c5a receptor on intact human polymorphonuclear leukocytes.	human c5a, a complement-derived anaphylatoxin, is a potent mediator of human leukocyte chemotaxis. using a homogeneous preparation of c5a that was 125i-labeled, we have demonstrated the presence of a specific cellular receptor for this glycoprotein on intact human polymorphonuclear leukocytes. cellular uptake of the radiolabeled ligand occurred rapidly and the rate of dissociation was extremely slow. cellular binding was saturable with respect to 125i-labeled c5a, and half-saturation occurred at ...	1978	279010
[diagnosis of candida albicans mycosis in gynaecology by the germ tube test (author's transl)].	experience with the germ tube test for the diagnosis of candida mycosis in gynaecology and dermatology is reported. candida albicans forms germ tubes in human serum and other culture media at 37 degrees c within 2 to 3 hours. if the initial culture grows yeast, the germ tube test permits the exact identification of the yeast as candida albicans within three to five hours. the specificity of the test is approximately 99%. of 3270 samples 934 grew yeast and 742 were candida albicans by the germ tu ...	1978	342332
[antibody monstration in blastomyces infections].	the evidence of humoral antibodies against yeasts can be a valuable help in the diagnosis of such infections. it is however necessary to use several sensitive methods, which complete one another in the detection of the different immunoglobulins. in the interpretation of the results the titer dynamic is decisive, especially in those patients whose antibody answer is suppressed by their disease and/or their therapeutic treatment. in most of the yeast infections candida albicans can be used as anti ...	1978	342449
[phagocytosis of saccharomyces cerevisiae in man: technics and characteristics].		1978	349623
adherence of candida albicans to human buccal epithelial cells.	the adherence of candida albicans to human buccal epithelial cells after 2 h at 37 degrees c was significantly greater in human saliva than in phosphate-buffered saline. in saliva, viable fungi adhered much better than did nonviable fungi, and this adherence was greater at 37 than at 25 degrees c. viable yeasts, preincubated in saliva for 90 min at 37 degrees c before being washed and mixed with epithelial cells in phosphate-buffered saline, adhered better than nonviable yeasts or yeasts preincu ...	1978	361571
implications of rna-rna splicing in evolution of eukaryotic cells.	the differences in the biochemistry of messenger rna formation in eukaryotes compared to prokaryotes are so profound as to suggest that sequential prokaryotic to eukaryotic cell evolution seems unlikely. the recently discovered noncontiguous sequences in eukaryotic dna that encode messenger rna may reflect an ancient, rather than a new, distribution of information in dna and that eukaryotes evolved independently of prokaryotes.	1978	364651
mutagenicity of industrial compounds. vii. styrene and styrene oxide: ii. point mutations, chromosome aberrations and dna repair induction analyses.	the possible genetic effects produced by styrene have been investigated by means of different methodologies in several biological organisms: (a) the induction of point mutation has been investigated in salmonella typhimurium (reverse mutation), in the yeast schizosaccharomyces pombe (forward mutation), both in vitro and in vivo, in the host-mediated assay of mice, and in the chinese hamster cell line grown in vitro (v-79) (forward mutation); (b) the induction of chromosome mutation has been inve ...	1978	366743
energy-related pollutants in the environment: use of short-term tests for mutagenicity in the isolation and identification of biohazards.	in an effort to gather information on the potential genetic hazards of existing or proposed energy-generating or -conversion systems, we have begun a correlated analytical and genetic analysis of a number of technologies. the work is divided into two phases: one deals with known compounds expected to occur in the environment through energy production, conversion, or use; the other deals with actual samples from existing or experimental processes. to approach the problems of coping with and testi ...	1978	367762
on the incidence of yeast species from human sources in finland. ii. yeasts from vaginal discharge.		1978	368625
general criteria for assessing the evidence for carcinogenicity of chemical substances: report of the subcommittee on environmental carcinogenesis, national cancer advisory board.	the evaluation of the potential human hazards of a given agent must be individualized in terms of the chemical and metabolic aspects of the agent, its intended use, and the data available at the time. an agent is carcinogenic in man if it increases the incidence of malignant neoplasms, or a combination of benign and malignant neoplasms in humans to levels that are significantly higher than those in a comparable group not exposed to the agent. types of evidence suggesting that an agent is carci ...	1977	851453
severe generalized glutathione reductase deficiency after antitumor chemotherapy with bcnu" [1,3-bis(chloroethyl)-1-nitrosourea].	patients receiving bcnu [1,3-bis(2 chloroethyl)-1-nitrosourea] acquire a profound deficiency of erythrocytic oxidized glutathione reductase (gssg-r) within minutes after the first intravenous injection of a single therapeutic dose (75 mg/m.2) of the drug. this effect is not accompanied by changes in the activites of 19 additional erythrocytic enzymes tested, is reproducible in vitro in a dose-related manner, and is not caused by the antitumor agents administered concurrently with the nitrosourea ...	1977	870569
affinity labeling of human serum prealbumin with n-bromoacetyl-l-thyroxine.	affinity labeling of human serum prealbumin with n-bromoacetyl-l-thyroxine (bract4) was used to investigate the binding domain for l-thyroxine (t4) on prealbumin. fluorescence titration with 8-anilinonaphthalene-1-sulfonate revealed a strong and a weak binding site for bract4 (k1 = 1 x 10(8) m-1; k2 = 1 x 10(6) m-1). the reaction of bract4 with prealbumin to form a covalent bond was inhibited in the presence of t4 and binding of t4 to prealbumin was nearly abolished after affinity labeling with ...	1977	893396
studies on the mechanism of action of halofenate.	this paper reviews most of the clinical studies on the mode of action of halofenate, an established hypolipidemichypouricemic agent in man. in yeast cutlures and in isolated rat adipocytes, halofenate was found to inhibit the conversion of pyruvate to acetyl coa. while pyruvate dehydrogenase was inhibited in vitro, halofenate also inhibited the activety of various other isolated enzymes. in rats maintained on halofenate in the diet (0.02-0.10%) for 2-14 days, there were 20-40% decreases in plasm ...	1977	319318
serum complement-like opsonic activities in human, animal, vegetable, and proprietary milks.	human, animal, proprietary, and soy milks are comparable to human serum c5 in opsonization of baker's yeast. bovine milk and human serum opsonically reconstitute c5-deficient mouse serum. such reconstitution is selectively inhibited by antiserum to human c5. further characterization suggests that bovine milk contains material structurally and functionally similar, but not identical, to human c5.	1977	323975
characteristics of the phagocytic process assessed by coulter counter.	the phagocytosis in suspensions of heat-killed yeast cells, saccharomyces cerevisiae, by human polymorphonuclear leucocytes was studied in vitro by means of an electronic particle counter, the coulter counter, and a 100-channel pulse-height analyzer, the channelyzer. the two cell populations were separated from each other electronically by the channelyzer. phagocytosis was recorded as disappearence of yeast cells. concomitantly, aggregation and swelling of the pmn-cells were observed, which incr ...	1977	327754
kinetics of phagocytosis and intracellular killing of candida albicans by human granulocytes and monocytes.	the study of the phagocytosis and intracellular killing of candida albicans by granulocytes and monocytes has been hampered by the budding and pseudomycelium formation of this yeast during a relatively short incubation period at 37 degrees c and by the similar density of candida cells and phagocytes, which makes differential centrifugation impossible. in the present study, c. albicans was used after 5 days of preculture at 30 degrees c, after which the number of candida cells remained constant d ...	1977	330404
hemagglutination of human group a erythrocytes by enterotoxigenic escherichia coli isolated from adults with diarrhea: correlation with colonization factor.	enterotoxigenic escherichia coli (etec) of several different serotypes isolated from adults with diarrhea and known to possess the colonization factor antigen (cfa) were found to cause mannose-resistant hemagglutination (ha) of human group a erythrocytes. cfa-negative e. coli isolated during the same study did not possess the mannose-resistant hemagglutinin, although some non-etec, cfa-negative isolates did exhibit mannose-sensitive ha activity. the mannoseresistant hemagglutinin of etec was fou ...	1977	336541
characterization of a regulatory mutant of fructose 1,6-bisphosphatase in saccharomyces carlsbergensis.	the fdp mutation has been localized on the genome of saccharomyces carlsbergensis, on chromosome ii, between lys2 and tyr1, at a man distance of 31 centimorgan from lys2. since the fdp mutant does not grow on glucose, fructose, mannose and sucrose, hexose transport and a number of enzymes of carbon metabolism were tested, but no significant differences could be found between the wild type and the mutant. only the regulatory properties of glycogen synthetase are changed in the mutant, but it is d ...	1977	197389
the extracellular release of granulocyte collagenase and elastase during phagocytosis and inflammatory processes.	human granulocytes release 25-30% of the granular neutral proteases, collagenase and elastase, to the exterior of the cell during phagocytosis of yeast cells or immune complexes. similar amounts of myeloperoxidase and lactoferrin are released. crossed immunoelectrophoresis demonstrated that collagenase and elastase released extracellularly formed complexes with serum alpha1-antitrypsin. the presence of alpha1-antitrypsin complexes with granulocyte collagenase and elastase were also demonstrated ...	1977	197589
identification of amber and ochre mutants of the human virus ad2+nd1.	although human adenoviruses grow poorly in monkey cells, this defect can be overcome either by coinfection of cells with simian virus 40 (sv40) or by insertion of the relevant portion of the sv40 genome into the adenovirus genome to form an adenovirus-sv40 hybrid virus. the nondefective adenovirus-2-sv40 hybrid virus, ad2+nd1, contains an insertion of 17% of the sv40 genome, which codes for at least part of a 30,000 dalton protein. a set of ad2+nd1 host-range mutants that have lost the ability t ...	1977	200921
a spin-label study of biological membranes with special emphasis on calcium-induced lateral phase separation.		1976	176878
transfer of trnas to somatic cells mediated by sendai-virus-induced fusion.	trnas from yeast (trnaphe and 4s rna) and escherichia coli (suiii+ trnaityr) have been transferred to mouse cells by means of a two-step transfer procedure [loyter, zakai, and kulka (1975) j. cell biol. 66, 292-304; schlegel and rechsteiner (1975) cell 5, 371-379]. in the first stage of the transfer trnas were incorporated into rabbit red blood cells (rbcs). thereafter, the loaded erythrocytes were fused with recipient mouse cells by means of sendai virus. at least 0.3-0.4% of the total input of ...	1976	183211
evaluation of mannich bases and related compounds as inhibitors of mitochondrial function in yeast and inhibition of blood platelet aggregation, blood clotting, and in vitro metabolism of 5-dimethylamino-1-phenyl-1-penten-3-one hydrochloride.	dimethylamino-1-phenyl-1-penten-3-one hydrochloride (ia) and 32 analogs were tested for inhibition of respiratory-dependent growth in saccharomyces cerevisiae. thirteen of the 33 compounds tested appeared to affect mitochondrial function, since the inhibition of respiratory-dependent growth was statistically greater than the inhibition of growth on fermentable energy sources. inhibition of mitochondrial function in yeast and growth inhibition of an in vitro culture of human epidermoid carcinoma ...	1976	775052
interactions between econazole, a broad-spectrum antimicrobic substance, and topically active glucocorticoids.	econazole is a broad-spectrum antimicrobic substance which acts by permeabilizing the cell membranes. glucocorticoids by their surface activity may counteract this effect by protecting the cell membranes. in fact, a protective action of glucocorticoids in high concentrations against econazole nitrate could be demonstrated in yeasts, not in staphylococci. the techniques applied were the warburg assays (resting yeasts, resting and proliferating bacteria). the elicitation of a blanching reaction on ...	1976	791715
freeze-fracture ultrastructural alterations induced by filipin, pimaricin, nystatin and amphotericin b in the plasmia membranes of epidermophyton, saccharomyces and red complex-induced membrane lesions.	the effects of chemically different polyenes on fungal membranes (epidermaphyton floccosum, a human pathogenic fungus, and saccharomyces cerevisiae) and human red blood cell membranes were studied by freeze-fracture electron microscopy in order to elucidate the interaction of these antibiotics with ergosterol. each type of neutral, small amphoteric and large amphoteric polyenes produces a distinct morphoneutral, small amphoteric and large amphoteric polyenes produces a distinct morphological eff ...	1976	793632
a simplified hyaluronic acid based culture medium for mycobacteria isolated from human lepromata.	acid-fast bacilli multiplied in liquid culture media containing hyaluronic acid when inoculated with mycobacteria from a lepromatous leprosy nodule. the culture was readily subcultured at ten day intervals in the homologue media, but failed to grow in the dubos, middlebrook and lowenstein media. these findings confirm the results of skinsnes et al (1975). identification of this culture is not yet available, however it gives positive immunofluorescence with authentic anti-m. leprae serum. the obt ...	1976	798728
crystalline 3-phospho-d-glycerate kinase from horse muscle.	phosphoglycerate kinase has been isolated in crystalline form from horse muscle. a convenient isolation procedure is described that yields homogeneous enzyme of specific activity 700 units/mg (30 degrees c). the enzyme is monomeric, and has a molecular weight 47 000. of the eight cysteine residues in the protein, two react rapidly with nbs21 with the concomitant loss of the catalytic activity. since the isolation of phosphoglycerate kinase from yeast (bücher, 1955) there have been several report ...	1976	985698
effect of sodium-salicylate on the function of cultured, human mononuclear cells.	the in vitro effect of na-salicylate on some functions of human mononuclear cells was studied. in therapeutical concentrations the drug was found to interfere both the function of lymphocytes and monocytes/macrophages. na-salicylate in concentrations of 400-800 mug/ml slightly inhibited the digestion of yeast particles. when the drug was present in the culture medium in doses above 160 mug/ml during the cell differentiation period from 90 minutes to the 8th day of culture, a reduction in the num ...	1976	998271
[temperature dependence of the sedimentation velocity of human erythrocytes].	the sedimentation velocity of yeast cells and human erythrocytes as a function of temperature was studied in a range from 6 degrees c to 40 degrees c. whereas this function for yeast cells can be described by an exponential function the measurements with erythorcytes show minima at 10 degrees c and 20 degrees c, respectively, and maxima at 13 degrees c and 38 degrees c. changes of the density or the shape of the cells cannot be the reason for these effects. viscosity measurements on erythrocyte ...	1976	1020570
isolation of blastomyces dermatitidis from pigeon manure.	we recently diagnosed and treated a 45-year-old white male horticulturist with acute progressive blastomycosis. epidemiologic studies revealed that the patient used a load of pigeon manure as fertilizer approximately 6 weeks before becoming ill. he used the pigeon manure only once, resealed the remainder, and stored it in his hothouse. samples of the pigeon guano were digested with 10 per cent koh, and the characteristic yeast forms of blastomyces dermatitidis were seen in large numbers. the fun ...	1976	1034455
the influence of d-penicillamine on enzymatic activities: glucose-6-phosphate dehydrogenase. correlation with serum levels measured in humans.	the influence of d-penicillamine on glucose-6-phosphate dehydrogenase of yeast (pure enzyme), human hemolysate, and human skin homogenate were determined. in high concentrations, d-penicillamine inhibits glucose-6-phosphate dehydrogenase activity (concentrations above 6.7 mmol/l, i. e. l g/l). in low concentrations, d-penicilliamine exerts an indirect influence by removing some inhibiting metal ions, such as zinc. in human skin homogenates, an activating action of d-penicillamine on glucose-6-ph ...	1976	1271018
hereditary deficiency of the seventh component of complement.	deficiency of the seventh component of complement has been found in the serum of a 42-yr-old caucasian woman who has raynaud's phenomenon, sclerodactyly, and telangiectasia. partial deficiency was found in the serum of the patient's parents and children, indicating a pattern of inheritance of autosomal codominance. transfusion experiments indicated that exogenous c7 had a 91-h halk-life in the patient. there was no evidence for c7 synthesis after transfusion. no c7 inhibitors were detected in th ...	1975	1099121
[newer antimycotics. i. derivatives of phenyl-hydrazine (author's transl)].	the author produced a number of derivatives of phenyl-hydrazine and its analogues, investigated their antimicrobial efficiency in vitro, and discussed the association of chemical structure with the fungistatic effect in the series of phenyl-hydrazine-derivatives. from the author's results it can be concluded that the halogen-substituted phenyl-hydrazines and their n-(acetyl)-derivatives exert a moderate fungistatic effect (tab. 1). in the series of n-aryl-sulphonyl-n'-phenyl-hydrazines only the ...	1975	1099848
wound infection by prototheca wickerhamii, a saprophytic alga pathogenic for man.	biopsy of a wound infection of the palmar fascia in a young diabetic woman revealed characteristic periodic acid-schiff-positive prototheca species cells with a rosette configuration and internal septation. prototheca wickerhamii was cultured repeatedly from the wound drainage and the biopsy tissue. several diagnostic features distinguishing prototheca species, saprophytic algae, from yeasts are: the formation of endospores by mitosis; greater variation in cell size (2 to 15 mum); the presence o ...	1975	1225929
immunochemical studies on l-rhamno-d-mannans of sporothrix schenckii and related fungi by use of rabbit and human antisera.	antisera were prepared in rabbits against the human pathogenic yeast sporothrix schenckii (strain 1099.12) grown at two different temperatures (25 degrees and 37 degrees). precipitation and inhibition data showed that the former serum had a specificity directed against alpha-l-rhap-(1 yields 2)-alpha-l-rhap-(1 yields 3)-d-man-(1 yields determinants, whereas the latter had a broad specificity in which alpha-l-rhamnosyl or alpha-l-rhap-(1 yields 3)-d-man- was the immunodominant structure. these re ...	1975	804993
the influence of amino acid substitutions on the conformational energy of cytochrome c.	conformational energies have been evaluated for each of the staggered side-chain conformations associated with the 261 amino acid substitutions known to occur among 60 eucaryotic species. at least 86% of these substitutions can be sterically accommodated (one at a time) within the structure of horse-heart cytochrome c resulting from conformational energy refinement. simultaneous incorporation of all pertinent amino acid substitutions found in eight representative species into the refined horse-h ...	1975	169879
the distribution of pyrophosphatidic acid in nature.	the occurrence of a novel phospholipid, pyrophosphatidic acid, in the lipid extracts of yeasts (23 species), bacteria (e. coli), algae (chlorella), mammalia (human, rabbit, guinea pig, and mouse), insect (cockroach), fish (carp), mollusc (clam), and spermatophyta (spinach) was investigated. pyrophosphatidic acid was found exclusively in the lipid extracts of several kinds of yeast species, but not in other normal living species (animals, plants, and microorganisms) so far investigated. all of th ...	1975	175047
characterization and evaluation of a soluble antigen complex prepared from the yeast phase of histoplasma capsulatum.	soluble yeast-phase (yps) antigen preparations (reeves et al., 1972) were obtained from three strains of histoplasma capsulatum. these were analyzed by agar-gel diffusion and complement fixation tests with human sera from known cases of histoplasmosis. two of the preparations contained the h and m antigens normally found in histoplasmin, whereas the third preparation contained the h but not the m antigen. in addition, a group of unknown antigens, designated as the y (yeast) antigens, were demons ...	1974	4208527
molecular basis for the selective toxicity of amphotericin b for yeast and filipin for animal cells.	among the polyene antibiotics, many, like filipin, cannot be used clinically because they are toxic; amphotericin b, however, is useful in therapy of human fungal infections because it is less toxic. both the toxicity of filipin and the therapeutic value of amphotericin b can be rationalized at the cellular and molecular level by the following observations: (i) these polyene antibiotics showed differential effects on cells; filipin was more potent in lysing human red blood cells, whereas amphote ...	1974	15825391
production of vascular permeability factor by enterotoxigenic escherichia coli isolated from man.	enterotoxin preparations derived from escherichia coli strain h-10407 were shown to contain vascular permeability factor (pf) activity as well as diarrheagenic activity. intradermal injection of e. coli enterotoxin (ect) caused localized induration and permeability of small blood vessels of the skin to intravenously administered evans blue dye. the pf assay described here demonstrated a linear dose response and was at least as sensitive as the adult rabbit ileal loop assay for detecting ect. e. ...	1973	4584048
genetic activity of metabolites in the ascitic fluid and in the urine of a human patient treated with cyclophosphamide: induction of mitotic gene conversion in saccharomyces cerevisiae.		1973	4586436
morphologica and structural changes during the yeast-to mold conversion of phialophora dermatitidis.	the details of the morphological and structural events occurring during yeast-to-mold conversion of the human pathogenic fungus phialophora dermatitidis as seen by phase-contrast microscopy and electron microscopy are described and illustrated. budding yeasts growing exponentially were observed to have thin walls and a cytoplasm exhibiting the characteristics of rapidly growing cells including numerous mitochondria, abundant ribosomes, few vacuoles, and little accumulation of storage material. i ...	1973	4120203
formation of c3a and c5a anaphylatoxins in whole human serum after inhibition of the anaphylatoxin inactivator.	two biologically and chemically distinct anaphylatoxins (ats) could be generated in whole human serum after removal of the at inactivator (ai) by immune-absorption or after inhibition of ai with 1 m epsilon-aminocaproic acid (eaca). both human ats could be generated by treatment of serum with antigen-antibody complexes, which activate the classical complement pathway, and with inulin or yeast, both of which trigger the alternate pathway. the ats were isolated from serum in active form and charac ...	1973	4121926
the availability of food folate in man.		1973	4201754
human erythrocyte phosphoglycerate kinase: purification, properties, and interaction with its antibody.		1973	4202713
isolation of a new soluble antigen from the yeast phase of histoplasma capsulatum.	a method is described by which a soluble antigen was prepared from the yeast phase of histoplasma capsulatum. this soluble preparation had a specificity greater than that of whole-cell yeast-phase antigens. in complement fixation tests with sera from human cases of histoplasmosis, blastomycosis, and coccidioidomycosis, the soluble antigen reacted in 12.1% of 141 tests with heterologous sera, whereas conventional whole-cell yeast antigens reacted in 47.3% of 91 tests with heterologous sera. the r ...	1972	4640739
lysosomal localization of -fructofuranosidase-containing liposomes injected into rats.	yeast beta-fructofuranosidase (invertase) or (131)i-labelled albumin were entrapped into liposomes composed of phosphatidylcholine, cholesterol and phosphatidic acid. of the beta-fructofuranosidase activity in the liposomal preparations 96-100% was latent. the following observations were made in experiments with rats injected with protein-containing liposomes. 1. after injection of beta-fructofuranosidase-containing liposomes (220 units or 1.5mg of beta-fructofuranosidase and 17.5mg of lipid), b ...	1972	4646772
functional aspects of a second mechanism of candidacidal activity by human neutrophils.	we tested the ability of human neutrophils to kill five candida species and the yeast torulopsis glabrata. c. parapsilosis and c. pseudotropicalis were found to be killed readily by normal and myeloperoxidase-deficient neutrophils and were selected to probe the myeloperoxidase-independent fungicidal mechanisms of the neutrophil. these organisms were killed with relatively normal (c. parapsilosis) or moderately reduced (c. pseudotropicalis) effectiveness by neutrophils from two boys with x-linked ...	1972	5066510
relationship of nervous tissue transketolase to the neuropathy in chronic uremia.	patients with chronic uremia develop neurologic defects which are similar to the demyelinating lesions seen in thiamine deficiency. the present study describes inhibitory effects of uremic material on nervous tissue transketolase, a thiamine-dependent enzyme of the pentose phosphate pathway which has been reported to have functional importance in the metabolism of myelinated nervous structures. transketolase activity (tka) of normal human brain and spinal cord was measured by the conversion of r ...	1971	5096513
the c3-activator system: an alternate pathway of complement activation.	evidence has accumulated indicating the existence of a second complement activation mechanism which is functionally analogous to c1, c2, and c4. the noncomplement protein c3pa, previously recognized through its ability to form a complex enzyme with a protein from cobra venom, appears to be the precursor of the c4,2 analogue. it is a thermolabile beta-globulin with a molecular weight of 80,000. when serum is treated with naturally occurring plant or bacterial polysaccharides, the c3pa is cleaved ...	1971	19867385
serological comparison of the two morphological phases of paracoccidioides brasiliensis.	the antigenic relationship of six different strains of paracoccidioides brasiliensis was investigated by the agar-gel immunodiffusion test. soluble antigens prepared from the two morphological phases of the fungus were diffused against human sera obtained from eight patients with paracoccidioidomycosis (south american blastomycosis). the mycelial phase showed common antigenic determinants as revealed by the formation of identical precipitin bands. the yeast phase proved to be more complex. most ...	1970	16557830
methanol activity o alcohol dehydrogenases from human liver, horse liver, and yeast.		1970	4318994
262 yeast strains of human origin isolated in caracas, venezuela.		1969	5311974
[yeast-like fungi of the genus candida in the organs of man. (necropsy study)].		1969	5366863
isopentenyladenosine stimulates and inhibits mitosis of human lymphocytes treated with phytohemagglutinin.	the plant cytokinin isopentenyladenosine, a component of yeast and mammalian transfer ribonucleic acid, is both a potent inhibitor and stimulator of dna synthesis, transformation, and mitosis of the phytohemagglutinin-stimulated lymphocyte. the stage of the cell cycle and the concentrations used are critical for these effects. the addition of isopentenyladenosine within the first 12 hours after phytohemagglutinin at a concentration above 10(-6) molar results in inhibition, while lower concentrat ...	1969	5789436
[growth characteristics and development of the content of cellular constituents of yeast and mycelial phases of sporotrichum schenckii, dimorphic fungus poisonous to man].		1968	5714011
[studies on the survival in sea water of several yeast strains isolated from man].		1967	5624528
[yeast-like flora in 330 samples of human saliva].		1967	5232279
studies on sphingosines. ii. the chemical structure of phytosphingosine of human origin and a note on the lipid composition of the yeast hansenula ciferrii.		1966	5964492
culture of human genital "t-strain" pleuropneumonia-like organisms.	ford, denys k. (university of british columbia, vancouver, canada). culture of human genital "t-strain" pleuropneumonia-like organisms. j. bacteriol. 84:1028-1034. 1962.-the conditions under which "t-strain" pleuropneumonia-like organisms, as described by shepard, are best cultured were investigated. the organisms were found to grow on several types of nutrient agar and broth, of which pplo medium supplemented with yeast extract and horse serum was the simplest. subculture was possible through b ...	1962	16561968
some factors which affect the initiation of growth of cryptococcus neoformans.	howard, dexter h. (university of california, los angeles). some factors which affect the initiation of growth of cryptococcus neoformans. j. bacteriol. 82:430-435. 1961.-the observation that a strain of cryptococcus neoformans failed to grow in a medium containing normal human serum led to an investigation of some of the physiological factors controlling initiation of growth by this fungus. the data presented show that the growth of c. neoformans is markedly inhibited in media with initial ph va ...	1961	13716208
a genetically determined human serum factor detected by its effect on a mating reaction in yeast.		1959	13834157
the effect of amphotericin b upon the yeast flora of the gastrointestinal tract of man.		1956	13425366
[hemagglutination with polysaccharide antigens of candida albicans and saccharomyces cerevisiae with immune sera and human sera].		1956	13433060
new bacteriological aspects of leprosy. v. chemiotherapic tests in vitro on the etiological agent of human leprosy (pseudo-yeast shape).		1955	13303905
urinary uric acid excretion after the ingestion of isotopic yeast nucleic acid in the normal and gouty human.		1954	13192077
some new bacteriological aspects of leprosy. iii. results of inoculation of animals in the laboratory with (a) culture of the etiological agent of human leprosy in the yeast stage and (b) leproma.		1954	14363026
[biologic value of yeast proteins for man].		1950	14772208
[on yeast-like fungi isolated in man, in algeria].		1950	14800480
the availability of vitamins from yeasts; differences in the influence of live yeast on the absorption of pure thiamine hydrochloride, pure riboflavin and nitrogen by human subjects, and the effect of distribution of the vitamin doses.		1949	18150601
the availability of vitamins from yeasts the availability to human subjects of riboflavin from fresh and dried bakers' yeasts varying in viability.		1947	20259197
further studies on the availability to human subjects of thiamine from yeasts.		1946	21064570
availability to human subjects of riboflavin from yeasts.		1946	20984579
controversial aspects; yeast in human nutrition.		1946	20985688
the fate of bakers' yeast in the intestine of man and of the white rat.		1924	16559053