Publications

the role of helicobacter pylori in patients with hypothyroidism in whom could not be achieved normal thyrotropin levels despite treatment with high doses of thyroxine.	ôçéhelicobacter pylori infection is a most frequent cause of chronic gastritis. h. pylori may decrease absorption of oral thyroxine by decreasing gastric acid secretion in the stomach. in this study, we aimed to investigate the change in thyroid function tests of the cases after h. pylori eradication who were not responding to high doses of thyroxine treatment before h. pylori eradication.	2011	21435090
postvoid residuals remain unchanged in patients with postoperative thoracic epidural analgesia after thoracotomy.	we found in previous studies that thoracic epidural analgesia (tea) after open renal surgery via lumbotomy significantly impaired bladder function with decreased detrusor contractility and increased postvoid residuals under urodynamic assessment. here we evaluated the effect of tea on bladder emptying in patients undergoing thoracotomy.	2011	21455089
outlasting corticomotor excitability changes induced by 25 hz whole-hand mechanical stimulation.	the objective was to investigate if whole-hand mechanical stimulation (mstim) in the tapping-flutter frequency range induces outlasting post-stimulus changes in the hand region of the primary motor cortex. mstim was delivered to 12 healthy subjects for 20 min using a therapeutic stimulation device (swisswing bmr 2000). frequencies of 10 and 25 hz were tested in separate sessions, and for control additionally the foot sole was stimulated at 25 hz. motor evoked potentials (meps) after single (recr ...	2011	21455615
noninvasive investigation of asymmetrically conjoined tripus twins with features of rachipagus, parapagus dicephalus, and cephalopagus.	a hypothetical mechanism for conjoined twinning postulated by spencer ([2003] developmental malformations and clinical implications, baltimore: johns hopkins university press, p 1-476) suggests that, after separation, monovular twins fuse in one of eight predictable homologous sites. the tripus fetal specimen under study embodies characteristics of three types therefore preventing it from classification into a simple variant of any one of the eight twin types described by spencer. the aim of thi ...	2011	21433086
prosthetic rehabilitation, implant survival and quality of life 2 to 5 years after resection of oral tumors.	background: after oral tumor resection, structural and functional rehabilitation by means of dental prostheses is complex, and positive treatment outcome is not always predictable. purpose: the objective of the study was to report on oral rehabilitation and quality of life 2-5 years after resection of malignant oral tumors. materials and methods: data of 46 patients (57ôçâ-¦ôçâ7 years) who underwent oral tumor surgery were available. more than 50% of tumors were classified t3 or t4. open oro-nas ...	2011	21435159
spinal angiolipoma in a pregnant woman presenting with acute epidural hemorrhage.	a 26-year-old woman in week 31 of pregnancy presented to the emergency room with acute onset of paraplegia. her medical history was unremarkable. neurological examination revealed complete paraplegia, total sensory loss below the t7 dermatome, and significant vesicorectal dysfunction. mri revealed an intraspinal mass from t3 to t4, which was hyperintense on both t1-weighted and t2-weighted images. blood examination found no abnormality. she underwent emergent hemilaminectomy and removal of the h ...	2011	21435880
triclosan and thyroid-mediated metamorphosis in anurans: differentiating growth effects from thyroid-driven metamorphosis in xenopus laevis.	in a previously reported study, we used a standard metamorphosis anuran model to assess potential effect of the antibacterial agent triclosan (tcs) on normal prometamorphic xenopus laevis. results indicated that environmentally relevant tcs concentrations did not alter the normal course of thyroid-mediated metamorphosis in this standard anuran model. however, to examine potential effects of tcs exposure during premetamorphosis and to distinguish between effects on metamorphosis and effects on gr ...	2011	21436124
adenocarcinoma of the esophagogastric junction: neoadjuvant radiochemotherapy and radical surgery : early results and toxicity.	to retrospectively evaluate treatment results and toxicity following a combined approach consisting of neoadjuvant radiochemotherapy and radical surgery in advanced adenocarcinoma of the esophagus and gastroesophageal junction.	2011	21437768
examination of laryngoesophageal dysfunction-free survival as an endpoint in nonsurgical treatment of squamous cell carcinomas of the larynx and hypopharynx.	background: a recently published consensus guideline suggested a new endpoint for clinical trials involving cancer of the larynx and hypopharynx: laryngoesophageal dysfunction-free survival (ledfs). the authors of this report examined ledfs in the context of definitive radiotherapy alone (rt) or with concurrent chemoradiotherapy (crt). methods: patients with a stage iii to ivb squamous cell carcinomas of the larynx or hypopharynx who received definitive radiotherapy were included. consensus guid ...	2011	21437891
clinicopathologic features and determinants of gleason score of prostate cancer in ghanaian men.	objective: prostate cancer is reported to be more aggressive in blacks. we studied the clinicopathologic features of prostate cancer in ghana, in order to determine the factors responsible for them and to find out if there is any relationship between them. method: patients referred with a biopsy proven diagnosis of carcinoma of the prostate to the cancer center of korle bu teaching hospital, accra, ghana, from 2003 to 2007 were studied. information with respect to age at diagnosis, presenting sy ...	2011	21441045
purification, biochemical characterization, and bioactive properties of a lectin purified from the seeds of white tepary bean (phaseolus acutifolius variety latifolius).	the present work shows the characterization of phaseolus acutifolius variety latifolius, on which little research has been published, and provides detailed information on the corresponding lectin. this protein was purified from a semi-domesticated line of white tepary beans from sonora, mexico, by precipitation of the aqueous extract with ammonium sulfate, followed by affinity chromatography on an immobilized fetuin matrix. maldi tof analysis of phaseolus acutifolius agglutinin (paa) showed that ...	2011	21441861
carbon ion therapy for advanced sinonasal malignancies: feasibility and acute toxicity.	to evaluate feasibility and toxicity of carbon ion therapy for treatment of sinonasal malignancies. first site of treatment failure in malignant tumours of the paranasal sinuses and nasal cavity is mostly in-field, local control hence calls for dose escalation which has so far been hampered by accompanying acute and late toxicity. raster-scanned carbon ion therapy offers the advantage of sharp dose gradients promising increased dose application without increase of side-effects.	2011	21466696
revisiting low-dose total skin electron beam therapy in mycosis fungoides.	purpose: total skin electron beam therapy (tsebt) is a highly effective treatment for mycosis fungoides (mf). the standard course consists of 30 to 36 gy delivered over an 8- to 10-week period. this regimen is time intensive and associated with significant treatment-related toxicities including erythema, desquamation, anhydrosis, alopecia, and xerosis. the aim of this study was to identify a lower dose alternative while retaining a favorable efficacy profile. methods and materials: one hundred t ...	2011	21489711
physiological and therapeutical roles of ginger and turmeric on endocrine functions.	the natural product ginger (zingiber officinale) has active constituents gingerol, shogaol and zerumbone, while turmeric (curcuma longa) contains three active major curcuminoids, namely, curcumin, demethoxycurcumin, and bisdemethoxycurcumin. they have the same scientific classification and are reported to have anti-inflammatory and many therapeutic effects. this article reviews the physiological and therapeutic effects of ginger and turmeric on some endocrine gland functions, and signal pathways ...	2011	21476200
predicting ideal spinopelvic balance in adult spinal deformity.	object spinopelvic balance is based on the theory that adjacent segments of the spine are related and influenced by one another. by understanding the correlation between the thoracolumbar spine and the pelvis, a concept of spinopelvic balance can be applied to adult deformity. the purpose of this study was to develop a mathematical relationship between the pelvis and spine and apply it to a population of adults who had undergone spinal deformity surgery to determine whether patients in spinopelv ...	2011	21476795
in vitro fluorescence displacement investigation of thyroxine transport disruption by bisphenol a.	bisphenol a (bpa) is a chemical with high production volume and wide applications in many industries. although bpa is known as an endocrine disruptor, its toxic mechanisms have not been fully characterized. due to its structural similarity to thyroid hormones thyroxine (t4) and triiodothyronine (t3), one possible mechanism of bpa toxicity is disruption of hormone transport by competitive binding with the transport proteins. in this study, the binding interactions of bpa, t4, and t3 with three th ...	2011	21517007
s-ketamine modulates hyperalgesia in patients with chronic pancreatitis pain.	upper abdominal pain is a dominant feature of chronic pancreatitis. a key phenomenon in this context is hyperalgesia, typically associated with n-methyl-d-aspartate receptor activation. this exploratory study evaluates acute effects of s-ketamine, a noncompetitive n-methyl-d-aspartate antagonist, in modulating generalized hyperalgesia in chronic pancreatitis pain.	2011	21490522
image-guided radiotherapy for prostate cancer: a prospective trial of concomitant boost using indium-111-capromab pendetide (prostascint) imaging.	purpose: to evaluate, in a prospective study, the use of (111)in-capromab pendetide (prostascint) scan to guide the delivery of a concomitant boost to intraprostatic region showing increased uptake while treating the entire gland with intensity-modulated radiotherapy for localized prostate cancer. methods and materials: from september 2002 to november 2005, 71 patients were enrolled. planning pelvic ct and (111)in-capromab pendetide scan images were coregistered. the entire prostate gland receiv ...	2011	21477947
[effect of adipose differentiation-related protein on the apoptosis of h9c2 cells by palmitic acid.]	aim: to construct a eukaryotic expression vector for expressing adipose differentiation-related protein(adrp) protein and obtain a stable transfected h9c2 cell line. methods: (1)the full length dna fragment of adrp gene was amplified by pcr from the myocardium of adult sd rats and was inserted into pegfp-c1 with t4 ligase. after the identification of digestion and sequencing on the recombinant pegfp-c1-adrp, the recombinant was transformed into e.coli strain dh5α.and the positive recombinant pla ...	2011	21481311
the effect of milrinone on the intraoperative hemodynamics during off-pump coronary bypass surgery in patients with an elevated echocardiographic index of the ventricular filling pressure.	hemodynamic derangement during off-pump coronary artery bypass surgery (opcab) is mainly attributed to impaired filling and diastolic dysfunction. an elevated ratio of the mitral velocity to the early-diastolic velocity of the mitral annulus (e/e' > 15) is a relatively new indicator of diastolic function, and this was reported to be associated with impaired hemodynamics during opcab. we investigated the efficacy of milrinone on the perioperative hemodynamics and short term outcomes of patients w ...	2011	21490820
phage t4-induced dttp accretion bolsters a trnase-based host defense.	the anticodon nuclease (acnase) prrc is silenced in escherichia coli by an associated dna restriction-modification protein, activated by the phage t4-encoded anti-dna restriction factor stp and counteracted by t4's trna repair enzymes polynucleotide kinase and rna ligase 1. hence, only trna repair-deficient phages succumb to prrc's restriction. prrc's abc-atpase motor domains are implicated in driving its activation by hydrolyzing gtp and in stabilizing the activated acnase by avidly binding dtt ...	2011	21481433
peri-implant tissue response following connective tissue and bone grafting in conjunction with immediate single-tooth replacement in the esthetic zone: a case series.	purpose: this case series evaluated the peri-implant tissue response following extraction and immediate placement and restoration of an implant in conjunction with subepithelial connective tissue grafting (sctg) and bone grafting in the esthetic zone. implant success rates and the peri-implant tissue response were also reported. methods and materials: ten patients (four men, six women) with a mean age of 48 years (range, 35 to 70) underwent extraction and immediate tooth replacement with sctg an ...	2011	21483896
identification of differentially expressed thyroid hormone responsive genes from the brain of the mexican axolotl (ambystoma mexicanum).	the mexican axolotl (ambystoma mexicanum) presents an excellent model to investigate mechanisms of brain development that are conserved among vertebrates. in particular, metamorphic changes of the brain can be induced in free-living aquatic juveniles and adults by simply adding thyroid hormone (t4) to rearing water. whole brains were sampled from juvenile a. mexicanum that were exposed to 0, 8, and 18days of 50nm t4, and these were used to isolate rna and make normalized cdna libraries for 454 d ...	2011	21457787
evaluation of physical properties of enamel after microabrasion, polishing, and storage in artificial saliva.	this study evaluated the effect of microabrasion and polishing on the microhardness and roughness of bovine enamel, and the effect of artificial saliva on the hardness of enamel. bovine enamel blocks were used, forming the groups (n = 48): gi-37% phosphoric acid and pumice, gii--opalustre, and giii--whiteness rm. the groups were divided into different subgroups: (a) diamond paste, (b) fluoride prophylactic paste, and (c) without polishing. hardness tests were carried out at the following set tim ...	2011	21487176
[relationship between pd-1 expression on peripheral t lymphcytes and hbeag seroconversion after entecavir treatment in chronic hepatitis b patients.]	to observe longitudinally the expression of programmed death 1(pd-1) on peripheral blood t cells in chronic hepatitis b patients underwent antiviral treatment with entecavir (etv) and to explore the relationship between pd-1 expression and hbeag seroconversion. twenty hbeag positive patients underwent antiviral treatment with etv were followed up for 51 weeks. 14 patients remained hbeag positive and 6 patients achieved hbeag seroconversion. peripheral blood was collected at six time points: t0: ...	2011	21492509
oncologic outcomes after supracricoid partial laryngectomy.	objective. to review the oncologic outcomes of a series of supracricoid partial laryngectomy. design. case series with chart review. setting. la paz university hospital, madrid, spain. patients. forty-one patients with glottic or supraglottic squamous cell carcinoma who underwent supracricoid partial laryngectomy between 1998 and 2008 at the authors' institution. main outcome measure. local control rate, specific-disease survival rate, and overall survival rate. results. all patients were male, ...	2011	21493316
no causal relationship between yersinia enterocolitica infection and autoimmune thyroid disease: evidence from a prospective study.	the objective of this study was to evaluate prospectively the relationship between yersinia enterocolitica (ye) infection and the development of overt autoimmune hypo- or hyperthyroidism (study a) and the de novo occurrence of thyroid antibodies (study b). this was a prospective cohort study of 790 euthyroid women who were first- or second-degree relatives of autoimmune thyroid disease (aitd) patients. follow-up was 5 years, with annual assessments. study a was a nested case-control study in whi ...	2011	21488870
expression and function role of dna methyltransferase 1 in human bladder cancer.	background: the identification of potential tumor markers will help improve therapeutic planning and patient management. therefore, the aim of this study was to highlight the role of dna methyltransferase 1 (dnmt1) in bladder cancer. methods: a total of 50 samples of nonmalignant urothelium, 65 of muscle-invasive bladder cancers, 15 of distant metastasis, and 50 of nonmuscle-invasive bladder cancers were selected for immunohistochemical staining analysis. furthermore, human bladder cancer cell l ...	2011	21523767
salvage laryngectomy after primary radiotherapy: what are prognostic factors for the development of pharyngocutaneous fistulae?	in this evidence based case report we addressed the clinical question: which factors predict the occurrence of a pharyngocutaneous fistula after total laryngectomy in patients that already were treated with radiotherapy for a squamous cell carcinoma of the larynx? we searched for relevant synonyms for the domain, being patients earlier treated with radiotherapy for a squamous cell carcinoma of the larynx and having a recurrence for which a salvage total laryngectomy is necessary, with the outcom ...	2011	21493379
disruptive effects of persistent organohalogen contaminants on thyroid function in white whales (delphinapterus leucas) from svalbard.	we analysed levels of 56 organohalogen contaminants (ohcs) including brominated flame retardants, polychlorinated biphenyls (pcbs), and organochlorine pesticides in the blubber of white (beluga) whales (delphinapterus leucas) from svalbard, norway (n=12; 6 adults [5 males and 1 female] and 6 subadults [4 males and 2 females]) collected in 1996-2001. we also measured circulating levels of thyroid hormones (ths) and thyroid stimulating hormone (tsh) in the whales. the results confirm that ohc leve ...	2011	21497377
sequence characteristics of t4-like bacteriophage ime08 benome termini revealed by high throughput sequencing.	abstract:	2011	21524290
the new tumor, node, and metastasis staging system.	the seventh edition of the tumor, node, and metastasis (tnm) classification is based on the proposals of the staging project of the international association for the study of lung cancer (iaslc). the analyses of the iaslc international database of 81,015 patients diagnosed with lung cancer between 1990 and 2000 were used to validate the tnm descriptors. the changes include: the subclassification of t1 and t2 tumors into t1a (≤ 2 cm) and t1b (>2 and ≤ 3 cm), and t2a (>3 and ≤ 5 cm) and t2b (>5 an ...	2011	21500123
[effectiveness of transarticular approach in treating thoracic spinal stenosis of calcified ligament].	to investigate the effectiveness of transarticular approach in treating thoracic spinal stenosis due to ossification of ligamentum flavum (olf) and ossification of posterior longitudinal ligament (opll) at the same level.	2011	21500584
do children and adolescents with type 1 diabetes mellitus have a higher frequency of parietal cell antibodies than healthy controls?	parietal cell antibodies (pca) are markers of autoimmune gastritis (ag). ag can lead to hypergastrinemia and iron-deficiency anaemia (ida). compared to healthy controls, adults with type 1 diabetes mellitus (t1dm) show a higher prevalence of pca (1% vs 20%). the aim of the present study was to evaluate the frequency of pca in children and adolescents with t1dm compared to healthy controls and the clinical and biochemical markers.	2011	21502826
evaluation of the effect of l: -thyroxin therapy on endothelial functions in patients with subclinical hypothyroidism.	subclinical hypothyroidism (sh) is characterized by normal serum free t4 (ft4), free t3 (ft3) levels and increased serum thyroid-stimulating hormone (tsh) levels. endothelial dysfunction, which is an early step of atherosclerosis, has been reported in patients with subclinical hypothyroidism. the aim of this study is to evaluate endothelial functions and the effect of l: -thyroxin (l-t4) therapy on endothelial functions in sh. twenty-seven patients with sh and 22 healthy controls were evaluated ...	2011	21505892
variation of the position of the aorta relative to a kyphotic thoracic spine: safety margin for pedicle screw placement in the adult japanese population.	abstract: study design: an analysis of computed tomography images of the spine in adult japanese patients.objective: to evaluate the variation of the position of the aorta relative to a spine with a thoracic kyphotic angle and to verify the safety margin for transpedicular screw fixation.summary of background data: recent studies have suggested that the aorta is positioned more laterally and posteriorly in patients with idiopathic scoliosis than in normal patients; however, variation of the posi ...	2011	21508888
nociceptive inputs transmission in huntington's disease: a study by laser evoked potentials.	the aim of the present study was to evaluate pain perception and evoked responses by laser stimuli (leps) in mild not demented huntington's disease (hd) patients. twenty-eight hd patients and 30 control subjects were selected. leps were obtained by four scalp electrodes, (fz, cz, referred to the nasion; t3, t4, referred to fz), stimulating the dorsum of both hands. all patients were also evaluated by somatosensory evoked potentials (seps) by median nerve stimulation. only 3 patients referred pai ...	2011	21510231
the effects of bromazepam over the temporo-parietal areas during the performance of a visuomotor task: a qeeg study.	this study investigated the effects of bromazepam on qeeg when 14 healthy subjects were asked to perform a visuomotor task (i.e., motor vehicle driving task). the subjects were exposed to two experimental conditions: the placebo (pl) and 6mg of bromazepam (br 6mg), following a randomized, double-blind design on different days. specifically, we observe absolute power extracted from qeeg data for theta band. we expected to see a decrease in absolute theta power in the temporal and parietal areas d ...	2011	21511002
mct8: from gene to disease and therapeutic approach.	thyroid hormone metabolism and action are largely intracellular processes that require transport of the hormone across the plasma membrane by different transporters. two of these, mct8 and mct10, are close members of the monocarboxylate transporter family. mct8 is expressed in a variety of tissues, including liver, kidney, thyroid and brain. the mct8 gene is located on the x chromosome, and mutations in mct8 result in severe psychomotor retardation and low serum t4 and high t3 levels in affected ...	2011	21511238
development of hepatocellular carcinomas in patients with absence of tumors on a prior ultrasound examination.	background: to evaluate hepatocellular carcinoma (hcc) that developed in patients with no evidence of a tumor during a prior ultrasound (us) performed within 1 year of the diagnosis. methods: we retrospectively analyzed data for 100 consecutive patients with liver cirrhosis who had undergone us within 1 year prior to hcc diagnosis and who showed no liver lesions on the previous us. size and t stage of hcc were assessed as well as whether patients met surgical criteria for liver transplantation a ...	2011	21514759
effect of a combined iodine and selenium supplementation on i and se status of cows and their calves.	iodine (i) and selenium (se) deficiencies are commonly reported in cattle, however, there are also studies regarding a very high iodine supply. the aim of the study was to determine the long-term effect of i and se supplementation on non-pregnant cows, pregnant cows and their calves. the hypothalamus pituitary axis was investigated (tsh, t4, t3 assays) during a trh challenge on non-pregnant cows. twenty-four cows, half of them pregnant, were assigned into 2 diet-groups, one group with a low i (0 ...	2011	21514807
supranutritional selenium level affects fatty acid composition and oxidative stability of chicken breast muscle tissue.	a total of 128 broilers were used to investigate the effect of selenium (se) on fatty acid (fa) composition and oxidative stability of lipids in the breast muscle tissue. there were 4 replicates of 4 dietary treatments: t1 (basal diet with no added se), t2 (t1 with 0.15 mg se added per kg diet), t3 (t1 with 0.3 mg se added per kg diet) and t4 (t1 with 3.0 mg se added per kg diet). a yeast source was used for added se. breast muscle tissue was collected from two chickens per replicate pen for the ...	2011	21535232
[clinical analysis of malignant submandibular tumor].	the 14 cases of malignant submandibular tumor whose treatment outcome we analyzed between 1989 and 2008 included 5 of adenoid cystic carcinoma, 3 of squamous cell carcinoma, 2 each of mucoepidermoid carcinoma, and carcinoma ex pleomorphic adenoma, and 1 each of carcinosarcoma and large-cell carcinoma. one subject was diagnosed with t1, 7 with t2, 4 with t3, and 2 with t4. lymph node involvement occurred in 5, -1 with n1 and 4 with n2. none had distant metastasis on the first visit. seven were tr ...	2011	21516710
neoadjuvant chemotherapy for locally advanced breast cancer in a malaysian tertiary hospital.	introduction: neoadjuvant chemotherapy for locally advanced breast cancer is given with the aim of shrinking the disease sufficiently for surgery. however, many clinical trials investigating neoadjuvant chemotherapy regimens were conducted for operable breast cancer. methods and materials: patients with t3-4, n2 m0 breast cancer diagnosed between january 2005 and december 2008 and who received at least one cycle of neoadjuvant chemotherapy were eligible for this study. thirty-four patients were ...	2011	21517250
a case of tsh-producing adenoma treated with octreotide in combination with thiamazole for the control of tsh and thyroid hormones after trans-sphenoidal neurosurgery.	while tsh-producing adenoma (tshoma) is rare, the diagnosis is often delayed because the clinical features are heterogeneous. the patient was a 69-year-old woman who had been referred to the yachiyo medical center in august 2008, because of dyspnea, loss of appetite, weight loss of 10 kg, and diarrhea that lasted 4 years. we diagnosed this patient with pituitary tsh-producing macroadenoma. thyroid hormone concentration was increasing although the serum tsh level was within a normal range after t ...	2011	21519153
full-dose capecitabine with local radiotherapy: one of the treatment options for inoperable t4 breast cancer.	a 48-year-old woman presented with a 15-cm diameter tumor in her left breast with fixation to the chest wall and palpable axillary lymph nodes. pathology study showed pure-type mucinous carcinoma. pretreatment staging investigations showed multiple lung metastases, which resulted in the diagnosis of t4n2m1 breast cancer. four cycles of cyclophosphamide 700 mg/m(2)/epirubicin 70 mg/m(2) (ce) were performed initially, but the tumors decreased only within the treatment response criteria of stable d ...	2011	21519998
[effective reversal of muscle relaxation by rocuronium using sugammadex in a patient with myasthenia gravis undergoing laparoscopic cholecystectomy].	as myasthenia gravis affects neuromuscular transmission, these patients show various responses to neuromuscular blocking drugs. we report a successful use of the sugammadex in a myasthenic patient to reverse rocuronium-induced neuromuscular block. a 69-year-old woman was scheduled for laparoscopic cholecystectomy and total of rocuronium 20 mg was administered. after spontaneous recovery of t1, we administered sugammadex 200mg intravenously, reversing neuromuscular blockade to a train-of-four rat ...	2011	21520600
[bladder preservation using chemoradiation therapy for locally invasive bladder cancer].	we investigated the long-term results and molecular markers of outcome with selective organ preservation in invasive bladder cancer using chemoradiation therapy.	2011	21520632
diagnosis and treatment of hypothyroidism in tsh deficiency compared to primary thyroid disease: pituitary patients are at risk of under-replacement with levothyroxine.	objective achieving optimal thyroid hormone replacement is more difficult in tsh deficiency compared to primary hypothyroidism because of the inability to be guided by serum tsh levels. a combination of clinical symptoms and free thyroxine levels (ft4) are typically used to make a diagnosis and monitor replacement. we investigated the diagnosis of tsh deficiency in patients with pituitary disease and the adequacy of levothyroxine replacement compared with primary thyroid disease. design using ...	2011	21521256
association of thyroid autoimmunity with acne in adult women.	background during the last decades an increase has been observed regarding acne in adults and especially women. objective to evaluate the association between thyroid disorder and the presence of post-adolescent acne in adult women, comparing with healthy controls. methods 107 adult women with post-adolescent acne and 60 healthy controls were included. complete blood count and standard biochemical profile of c-reactive protein (crp) and levels of thyroid hormones and antibodies [triiodothyroni ...	2011	21521376
hair regrowth with topical triiodothyronine ointment in patients with alopecia areata: a double-blind, randomized pilot clinical trial of efficacy.	background thyroid hormone receptors are expressed in hair follicles and it is known that thyroid hormones can have a positive effect on hair growth, i.e. process which is disrupted in alopecia areata. objectives the aim of this study was to determine the efficacy of topical triiodothyronine in patients with patchy alopecia areata. methods ten patients with patchy alopecia areata were treated with triiodothyronine and placebo applied twice daily to either of two bilaterally symmetrical patche ...	2011	21521379
inability of rhtsh to predict the evolution from subclinical hypothyroidism to overt disease. a pilot study.	background: the use of recombinant human tsh is indicated to evaluate thyroid carcinoma patients. in recent years, some authors have reported that rhtsh could serve as a dynamic test of thyroid reserve. the aim of the present study was to determine whether or not rhtsh can predict the evolution from subclinical hypothyroidism (sh) to overt hypothyroidism. materials and methods: twenty-one women who met the diagnostic criteria of sh were enrolled. all patients received a single dose of rhtsh (0.1 ...	2011	21521938
the influence of prognostic factors and adjuvant chemoradiation on survival after pancreaticoduodenectomy for ampullary carcinoma.	introduction: the prognosis after pancreaticoduodenectomy (pd) for ampullary carcinoma (ac) is superior to that of pancreatic cancer. decisions regarding adjuvant therapy are influenced by factors such as nodal status, stage, and grade, but the influence of these individual variables on survival is unclear. methods: a prospective tumor registry database was queried to identify patients who underwent pd for ac at thomas jefferson university between jan 1997 and apr 2009. the study was conducted w ...	2011	21523621
patterns of extralaryngeal spread of laryngeal cancer: thyroid cartilage penetration occurs in a minority of patients with extralaryngeal spread of laryngeal squamous cell cancers.	background: laryngeal preservation programs for patients with advanced laryngeal squamous cell carcinomas (scc) have generally excluded patients with t4 disease. the accuracy of preoperative imaging in evaluating thyroid cartilage penetration and extralaryngeal spread (els) has previously been questioned. clinically, scc spread into noncartilaginous structures may have less of a functional impact when compared with thyroid cartilage penetration. the current study was designed to characterize and ...	2011	21523761
ultrasensitive microarray detection of short rna sequences with enzymatically modified nanoparticles and surface plasmon resonance imaging measurements.	a novel multiplexed method for short rna detection that employs an enzymatic capture reaction onto dna-modified silica nanoparticles (sinps) followed by nanoparticle-enhanced surface plasmon resonance imaging (spri) is demonstrated. sinps functionalized with 5'-phosphorylated single stranded dna (ssdna) are used with t4 rna ligase to capture various short 20-24 base single-stranded rna (ssrna) oligonucleotides from a target solution. the ssrna-modified sinps are collected from the target solutio ...	2011	21524060
metabolism and gastric remnant changes after roux-en-y gastric bypass in rats.	abstract background: the roux-en-y gastric bypass (rygb) may affect metabolism, microbiology, and histology of gastric remnant. therefore, this study aimed to investigate these issues in rats. methods: twelve rats were randomly allocated to a rygb group (n = 6) and nonoperated normal rats group (n = 6). after 30 postoperative days, all rats were injected with 0.1ml of na(99m)tc(-) i.v. (radioactivity 0.66 mbq). after 30 min, liver, stomach, thyroid, heart, lung, kidney, and femur samples were ha ...	2011	21524176
massive levothyroxine ingestion in a pediatric patient: case report and discussion.	abstractwe describe the course of a toddler who ingested a massive amount of levothyroxine and review treatment options for such overdoses. a 2½-year-old boy presented shortly after an ingestion of up to 7.6 mg of levothyroxine (potentially as much as 700 μg/kg). he was initially asymptomatic, treated with oral charcoal 1 g/kg, and discharged home from the emergency department after a few hours. he returned approximately 24 hours later with a temperature of 38.5°c, heart rate of 163 beats per mi ...	2011	21524373
dynamics of the t4 bacteriophage dna packasome motor: endonuclease vii resolvase release of arrested y-dna substrates.	conserved bacteriophage atp-based dna translocation motors consist of a multimeric packaging terminase docked onto a unique procapsid vertex containing a portal ring. dna is translocated into the empty procapsid through the portal ring channel to high density. in vivo the t4 phage packaging motor deals with y- or x-structures in the replicative concatemer substrate by employing a portal-bound holliday junction resolvase that trims and releases these dna roadblocks to packaging. here using dye-la ...	2011	21454482
implicit motor learning promotes neural efficiency during laparoscopy.	an understanding of differences in expert and novice neural behavior can inform surgical skills training. outside the surgical domain, electroencephalographic (eeg) coherence analyses have shown that during motor performance, experts display less coactivation between the verbal-analytic and motor planning regions than their less skilled counterparts. reduced involvement of verbal-analytic processes suggests greater neural efficiency. the authors tested the utility of an implicit motor learning i ...	2011	21455805
effects of sulphur and thiobacillusthioparus on cow manure aerobic composting.	a simulated aerobic composting experiment was used to explore the effects of sulphur and thiobacillusthioparus during six manure composting treatments. the addition of sulphur led to a decrease of the ph level within the range 6-6.3, which was lower than the control treatment (ck). the concentration of ammonium nitrogen in t1 (0.25% sulphur), t2 (0.5% sulphur), t3 (0.25% sulphur+t. thioparus) and t4 (0.5% sulphur+t. thioparus) were much higher than the ammonium n in ck. the results indicated tha ...	2011	21482106
inhibition of tumor angiogenesis in lung cancer by t4 phage surface displaying mvegfr2 vaccine.	vascular endothelial growth factor (vegf) has been known as a potential vasculogenic and angiogenic factor and its receptor (vegfr2) is a major receptor to response to the angiogenic activity of vegf. the technique that to break the immune tolerance of "self-antigens" associated with angiogenesis is an attractive approach for cancer therapy with t4 phage display system. in this experiment, mouse vegfr2 was constructed on t4 phage nanometer-particle surface as a recombinant vaccine. t4-mvegfr2 re ...	2011	21482223
characterization and comparison of the full 3' and 5' untranslated genomic regions of diverse isolates of infectious salmon anaemia virus by using a rapid and universal method.	the 3' and 5' untranslated regions (utrs) of the gene segments of orthomyxoviruses interact closely with the polymerase complex and are important for viral replication and transcription regulation. despite this, the 3' and 5' rna utrs of the infectious salmon anaemia virus (isav) genome have only been partially characterized and little is known about the level of conservation between different virus subtypes. this report details for the first time, the adaptation of a rapid method for the simult ...	2011	21458495
[correlation between serum thyroid hormone and dopamine levels and chinese medicine syndrome types].	to analyze the correlation between changes of thyroid hormone (th), dopamine (da) and chinese medicine syndrome types by detecting contents of serum th and da in insomnia, thus to explore objective indices of chinese medicine syndrome types.	2011	21485074
phospholipase activities in clinical and environmental isolates of acanthamoeba.	the pathogenesis and pathophysiology of acanthamoeba infections remain incompletely understood. phospholipases are known to cleave phospholipids, suggesting their possible involvement in the host cell plasma membrane disruption leading to host cell penetration and lysis. the aims of the present study were to determine phospholipase activities in acanthamoeba and to determine their roles in the pathogenesis of acanthamoeba. using an encephalitis isolate (t1 genotype), a keratitis isolate (t4 geno ...	2011	21461262
evaluation of thyroid functions with respect to iodine status and trh test in chronic autoimmune thyroiditis.	objective: chronic autoimmune thyroiditis (cat) is the most common form of thyroiditis in childhood and a frequent cause of acquired hypothyroidism. the objective of this study was to evaluate the thyroid status of childrenand adolescents with cat with respect to iodine status and diagnostic values of thyrotropin-releasing hormone (trh) test. methods: seventy-one children (mean age: 11.6 years) were studied in a retrospective analysis. free thyroxine (t4), thyrotropin (tsh), tsh response to trh ...	2011	21448329
increased expression of transcription factor tfap2α correlates with chemosensitivity in advanced bladder cancer.	abstract:	2011	21489314
maternal flaxseed diet during lactation programs thyroid hormones metabolism and action in the male adult offspring in rats.	flaxseed has several benefits for health such as improvement in lipid profile; and since thyroid hormones increases cholesterol biliary excretion, we decide to evaluate the programming effect of maternal flaxseed diet during lactation upon thyroid hormone metabolism and action in the adult offspring in rats. at birth, lactating rats were divided into: flaxseed dams (f) - diet with 25% of flaxseed - and controls dams (c). f and c pups received normal diet after weaning and male offspring were sac ...	2011	21448850
effect of zinc and iron fortification of the feed on liver and thyroid function in rats.	changes in plasma glutamate oxaloacetate transaminase (got), glutamate pyruvate transaminase (gpt), triiodothyronine (t3), and thyroxin (t4) of male rats, following 8 weeks of administration of different concentrations of elemental iron (ei), sodium iron ethylenediaminetetraacetate (nafeedta), zinc sulfate (znso(4)), and zinc oxide (zno) in whole wheat flour were investigated. liver enzymes and thyroid hormones were determined using colorimetric methods and enzyme immune assay, respectively. ing ...	2011	21468629
a rexinoid antagonist increases the hypothalamic-pituitary-thyroid set point in mice and thyrotrope cells.	retinoid x receptor (rxr) signaling influences thyrotrope function. synthetic rxr agonists, rexinoids, can cause central hypothyroidism. to test the hypothesis that endogenous rexinoids contribute to the tsh 'set point', tat1 mouse thyrotrope cells were treated with a rexinoid antagonist, lg101208. increasing concentrations of lg101208 significantly increased tshß mrna levels, indicating that the rexinoid antagonist may interfere with rxr-signaling by an endogenous rexinoid in thyrotropes. when ...	2011	21458528
[thyroid hormone resistance syndromes].	thyroid hormone resistance syndromes are a group of genetic conditions characterized by decreased tissue sensitivity to thyroid hormones. three syndromes, in which resistance to hormone action is respectively due to mutations in the gene encoding for thyroid hormone receptor trß, impaired t4 and t3 transport, and impaired conversion of t4 to t3 mediated by deiodinases. an updated review of each of these forms of resistance is provided, and their pathogenetic mechanisms and clinical approaches ar ...	2011	21459689
sagittal balance of thoracic lordoscoliosis: anterior dual rod instrumentation versus posterior pedicle screw fixation.	posterior pedicle screw fixation is now the standard treatment for surgical correction of idiopathic scoliosis and has largely replaced anterior techniques, but there have been reports describing a lordogenic effect of segmental pedicle screw instrumentation in the thoracic spine. this clinical study compared anterior dual rod instrumentation with posterior pedicle screw fixation for idiopathic thoracic lordoscoliosis, including 42 patients (7 male, 35 female; average age 16 years, range 12-34) ...	2011	21468646
fish thyroidal and stress responses in contamination monitoring--an integrated biomarker approach.	xenobiotics may affect fish endocrine system, making endocrine responses relevant in pollution monitoring. five critical sites in ria de aveiro (portugal), having different contamination profiles, were assessed in comparison to a reference site (torreira), focusing on liza aurata stress (plasma cortisol, glucose and lactate) and thyroidal (plasma thyroid stimulating hormone-tsh, thyroxine-t4 and triiodothyronine-t3) responses. l. aurata at vagos (pahs contaminated) and laranjo (mercury contamina ...	2011	21463897
outcomes of hepatic resection for huge hepatocellular carcinoma (=10?cm in diameter).	the object of the current study was to review the outcomes of hepatic resection for hepatocellular carcinoma (hcc)?=?10?cm.	2011	21465490
salivary zinc finger protein 510 peptide as a novel biomarker for detection of oral squamous cell carcinoma in early stages.	oral squamous cell carcinoma (oscc) is one of the most frequent malignancies worldwide. early diagnosis can mean adequate treatment and increase survival.	2011	21497587
ischemic post-conditioning attenuates the intestinal injury induced by limb ischemia/reperfusion in rats.	the purpose of this study was to investigate the protective effects of ischemic post-conditioning on damage to the barrier function of the small intestine caused by limb ischemia-reperfusion injury. male wistar rats were randomly divided into 3 groups (n = 36 each): sham operated (group s), lower limb ischemia-reperfusion (group lir), and post-conditioning (group pc). each group was divided into subgroups (n = 6) according to reperfusion time: immediate (0 h; t1), 1 h (t2), 3 h (t3), 6 h (t4), 1 ...	2011	21468513
novel mutation in mct8 gene in a brazilian boy with thyroid hormone resistance and severe neurologic abnormalities.	mct8 is a cellular transporter of thyroid hormones important in their action and metabolization. we report a male patient with the novel inactivating mutation 630insg in the coding region in exon 1 of mct8. he was characterized clinically by severe neurologic impairment (initially with global hypotonia, later evolving with generalized hypertonia), normal growth during infancy, reduced weight gain, and absence of typical signs and symptoms of hypothyroidism, while the laboratory evaluation disclo ...	2011	21468521
thermostabilisation of an agonist-bound conformation of the human adenosine a(2a) receptor.	the adenosine a(2a) receptor (a(2a)r) is a g-protein-coupled receptor that plays a key role in transmembrane signalling mediated by the agonist adenosine. the structure of a(2a)r was determined recently in an antagonist-bound conformation, which was facilitated by the t4 lysozyme fusion in cytoplasmic loop 3 and the considerable stabilisation conferred on the receptor by the bound inverse agonist zm241385. unfortunately, the natural agonist adenosine does not sufficiently stabilise the receptor ...	2011	21501622
specialization versus adaptation: two strategies employed by cyanophages to enhance their translation efficiencies.	effective translation of the viral genome during the infection cycle most likely enhances its fitness. in this study, we reveal two different strategies employed by cyanophages, viruses infecting cyanobacteria, to enhance their translation efficiency. cyanophages of the t7-like podoviridae family adjust their gc content and codon usage to those of their hosts. in contrast, cyanophages of the t4-like myoviridae family maintain genomes with low gc content, thus sometimes differing from that of the ...	2011	21470965
maternal thyroid function during pregnancy and behavioral problems in the offspring: the generation r study.	maternal thyroid function during pregnancy is implicated in the neurodevelopment of the offspring, yet little is known about the effect of maternal thyroid parameters on the behavior of children. we investigated the association of maternal thyroid function during the first half of pregnancy with parent-reported problem behavior of the offspring up to age of 3 y. in the generation r study, a population-based cohort of 3736 children and their mothers, data on maternal thyroid function and child's ...	2011	21471776
t4-like genome organization of the escherichia coli o157:h7 lytic phage ar1.	we report the genome organization and analysis of the first completely sequenced t4-like phage ar1 of e. coli o157:h7. unlike most of the other sequenced phages of o157:h7 strain that belong to the temperate podoviridae and siphoviridae families, ar1 is a t4-like phage known to efficiently infect this pathogenic bacterial strain. the 167,435-bp ar1 genome is currently the largest among all the sequenced e. coli o157:h7 phages. it encodes a total of 281 potential orfs and ten putative trna genes. ...	2011	21507986
dna ligases.	the dna ligase enzyme family catalyzes the formation of a phosphodiester bond between juxtaposed 5'-phosphate and 3'-hydroxyl termini in duplex dna. this activity can seal nicks in duplex dna or join double-stranded dna fragments having either blunt or cohesive ends. dna ligases are central enzymes in molecular biology, nucleic acid research, and in next-generation sequencing applications. reaction conditions and applications for t4 dna ligase, e. coli dna ligase, and thermostable dna ligases ar ...	2011	21472697
surgical outcomes and survival after extended multiorgan resection for t4 gastric cancer.	background: extended multiorgan resection (emr) for locally advanced (t4) gastric cancer remains controversial. the aim of this study was to evaluate the effectiveness of this approach with regard to morbidity, mortality, and survival. methods: between 2005 and 2009, 41 patients underwent aggressive surgery for clinical t4 gastric cancer. univariate and multivariate analyses were used to identify prognostic factors for surgical outcomes and survival in these patients. results: curative resection ...	2011	21474116
identification of interleukin 2, 6, and 8 levels around miniscrews during orthodontic tooth movement.	the aim of this study was to identify the levels of interleukin (il)-2, il-6, and il-8 around miniscrews used for anchorage during canine distalization. sixteen patients (eight males and eight females; mean age, 16.6 ± 2.4 years) who were treated with bilateral upper first premolar extractions were included in the study. thirty-two maxillary miniscrew implants were placed bilaterally in the alveolar bone between the maxillary second premolars and first molars as anchorage units for maxillary can ...	2011	21474566
colorectal cancer and 18fdg-pet/ct: what about adding the t to the n parameter in loco-regional staging?	to evaluate whether fdg-positron emission tomography (pet)/computed tomography (ct) may be an accurate technique in the assessment of the t stage in patients with colorectal cancer.	2011	21472100
spontaneous intracranial hypotension: efficacy of radiologic targeting vs blind blood patch.	the aim of this study was to evaluate the efficacies and compare the outcomes of targeted and blind epidural blood patch (ebp) treatments of spontaneous intracranial hypotension (sih).	2011	21444899
evaluation of the effect of l-thyroxin therapy on cardiac functions by using novel tissue doppler-derived indices in patients with subclinical hypothyroidism.	subclinical hypothyroidism (sh) is characterized by normal serum free t4 (ft4), free t3 (ft3) levels and increased serum thyroid stimulating hormone (tsh) levels.the aim of this study was to assess the validity of tissue doppler imaging (tdi) in evaluating cardiac effects of sh and to demonstrate the improving effects of l-thyroxin(l-t4) on tdi parameters.	2011	21446380
a pilot feasibility study of tnferade™ biologic with capecitabine and radiation therapy followed by surgical resection for the treatment of rectal cancer.	objective: the purpose of this pilot study was to evaluate the feasibility and tolerability of weekly intratumoral tnferade™ injections combined with concurrent capecitabine and radiotherapy in the treatment of patients with locally advanced rectal cancer. methods: patients with t3, t4, or n+ rectal cancer received radiotherapy to a total dose of 50.4-54 gy in combination with capecitabine 937.5 mg/m(2) p.o. b.i.d. tnferade™ at a dose of 4 × 10(10) particle units was injected into the rectal tum ...	2011	21447969
thyroid hypoplasia as a cause of congenital hypothyroidism in monozygotic twins concordant for rubinstein-taybi syndrome.	rubinstein-taybi syndrome (rsts), a genetic disorder characterized by growth retardation, mental deficiency, dysmorphic face, broad thumbs and large toes, generally affects monozygotic twins concordantly. thyroid hypoplasia (th) is a common cause of congenital hypothyroidism (ch) and often accompanies dysmorphic syndromes. a pair of female twins were admitted to our neonatology unit 16 hours after delivery. they were born at 35 weeks of gestation. both twins had an unusual dysmorphic facial appe ...	2011	21448332
prognostic factors of t4 gastric cancer patients undergoing potentially curative resection.	to investigate the prognostic factors of t4 gastric cancer patients without distant metastasis who could undergo potentially curative resection.	2011	21448423
detection of single-base mutation in rna using t4 rna ligase-based nick-joining or dnazyme-based nick-generation.	a single nucleotide polymorphism (snp) is a common genetic variation when a single nucleotide differs between members of a species or paired chromosome. due to its association with disease susceptibility and drug resistance, snp detection is of great value in studying the variation in drug responses. here we present two quantitative snp detection methods for a single-base mismatch in rna, based on nick-joining and nick-generating activities of t4 rna ligase and dnazyme, respectively. t4 rna liga ...	2011	21453671
qsar classification models for the prediction of endocrine disrupting activity of brominated flame retardants.	the identification of potential endocrine disrupting (ed) chemicals is an important task for the scientific community due to their diffusion in the environment; the production and use of such compounds will be strictly regulated through the authorization process of the reach regulation. to overcome the problem of insufficient experimental data, the quantitative structure-activity relationship (qsar) approach is applied to predict the ed activity of new chemicals. in the present study qsar classi ...	2011	21454014
implications of the inability of listeria monocytogenes egd-e to grow anaerobically due to a deletion in the class iii nrdd ribonucleotide reductase for its use as a model laboratory strain.	listeria monocytogenes is a gram-positive facultative intracellular bacterium that causes life-threatening diseases in humans. it grows and survives in environments of low oxygen tension and under conditions of strict anaerobiosis. oxygen-limiting conditions may be an important factor in determining its pathogenicity. l. monocytogenes serovar 1/2a strain egd-e has been employed intensively to elucidate the mechanisms of intracellular multiplication and virulence. listeria possesses genes encodin ...	2011	21478338
evaluation of ventricular functions using tissue doppler echocardiography in patients with subclinical hypothyroidism.	we evaluated right (rv) and left (lv) ventricle functions by tissue doppler imaging (tdi) in patients with subclinical hypothyroidism (sh).	2011	21430418
the prognostic and staging implications of bone invasion in oral squamous cell carcinoma.	background: a study was undertaken to determine whether bone invasion is an independent prognostic factor in oral squamous cell carcinoma (scc) after taking into account the extent of bone invasion. methods: the study was a retrospective review of 498 patients with oral scc undergoing surgery with curative intent, 102 of whom had pathologically proven bone invasion. bone invasion was categorized as absent, cortical, or medullary and tested for association with disease control and survival. resul ...	2011	21437887
acute t3 treatment protects the heart against ischemia-reperfusion injury via tra1 receptor.	we have previously shown that acute thyroid hormone treatment could limit reperfusion injury and increase post-ischemic recovery of function. in the present study, we further explore potential initiating mechanisms of this response. thus, isolated rat hearts were subjected to 30 min zero-flow global ischemia (i) followed by 60-min reperfusion (r). reperfusion injury was assessed by post-ischemic recovery of left ventricular developed pressure (lvdp%) and ldh release. t3 at a dose of 60 nm which ...	2011	21442236
correlation between fas and fasl proteins expression in normal gastric mucosa and gastric cancer.	the study's objective was to assess the expressions of fas and fasl proteins in gastric cancer in correlation with chosen clinicohistological parameters. fas and fasl expression was analyzed in 68 patients with gastric cancer, using the immunohistochemical method. the expression of fas was found to be lower in gastric cancer cells than in healthy mucosa, both in the lining epithelium and in glandular tubes (28% vs. 48% and 44%; p 〈 0.001). the expression of fasl was also markedly lower in cancer ...	2011	21526501
thyroid autoimmunity role in the evolution of endemic goiter in rural area, fars, iran.	who reports indicate no iodine insufficiency in iran, however, goiter is still endemic in fars province. this study evaluates the role of thyroid autoimmunity in the evolution of endemic goiter.	2011	21529102
treatment of a malignant peripheral nerve sheath tumor and its complications through a multidisciplinary approach.	the authors report the case of a 14-year-old girl with a residual malignant peripheral nerve sheath tumor after thoracotomy, chemotherapy, and radiation therapy. the residual tumor, which involved the intercostal muscles, aorta, and neural foramina of t4-10, was completely resected through a costotransversectomy and multiple hemilaminotomies with the patient in the prone position and was stabilized using a t1-12 pedicle screw fusion. postoperatively, the patient developed several infections requ ...	2011	21529197
titanium plates and dualmesh: a modern combination for reconstructing very large chest wall defects.	the reconstruction of large full-thickness chest wall defects after resection of t3/t4 non-small cell lung carcinomas or primary chest wall tumors presents a technical challenge for thoracic surgeons and plays a central role in determining postoperative morbidity. the objective is to evaluate our results in chest wall reconstruction using a combination of expanded polytetrafluoroethylene (eptfe) mesh and titanium plates.	2011	21531380
effects of hyperthyroidism, hypothyroidism and thyroid autoimmunity on female sexual function.	introduction: thyroid hormones affect male and female sexual functions, but data in hypo- and hyperthyroid women are scanty. aim: to investigate sexual function in hypo- and hyperthyroid women before and immediately after restoration of euthyroidism and in women with euthyroid hashimoto's thyroiditis (ht). patients and controls: fifty-six women with thyroid diseases (age 19-50 years; 22 with hyperthyroidism, 17 with hypothyroidism and 17 with euthyroid ht) and 30 age-matched healthy women. main ...	2011	21532331